Zahra Behroozi, Keihan Kookli, Alireza Ghadaksaz, Mahsa Motavaf, Seyedalireza Moghaddas Fazeli, Ali Motamed Nezhad, Fatemeh Ramezani, Atousa Janzadeh
Photobiomodulation therapy (PBMT) is converted to the most common analgesic treatment before the whole mechanism is yet to be discovered. This study for the first time was designed to investigate alternations of epigenetic factors after pain and PBMT. The CCI model was chosen to induce pain. Pain evaluation tests including plantar, acetone, von Frey, and pinch were done weekly. Then spinal cord tissue was isolated for evaluating mRNA expression of DNMT3a, HDAC1, and NRSF using RT-qPCR method, and protein expression factors of HDAC2 and DNMT3a using western blotting...
June 18, 2023: Photochemistry and Photobiology