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Shawneequa L Callier, Rachel Abudu, Maxwell J Mehlman, Mendel E Singer, Duncan Neuhauser, Charlisse Caga-Anan, Georgia L Wiesner
PURPOSE: This review identifies the prominent topics in the literature pertaining to the ethical, legal, and social issues (ELSI) raised by research investigating personalized genomic medicine (PGM). METHODS: The abstracts of 953 articles extracted from scholarly databases and published during a 5-year period (2008-2012) were reviewed. A total of 299 articles met our research criteria and were organized thematically to assess the representation of ELSI issues for stakeholders, health specialties, journals, and empirical studies...
November 2016: Bioethics
Johannes Schalamon, Thomas Petnehazy, Herwig Ainoedhofer, Christoph Castellani, Holger Till, Georg Singer
BACKGROUND: In an experimental study the performance of different closed abdominal drainage systems was tested. METHODS: A vacuum bottle designed for Redon Drainage, a flexible plastic bulb designed for Jackson-Pratt drains and a V.A.C.(®) Negative Pressure Wound Therapy System were used. In a porcine cadaveric study mimicking the abdominal cavity the intrinsic pressure (IP) at one and three minutes (T0, T3) and the amount of evacuated fluid were measured. RESULTS: The Redon and Jackson drainage displayed a rapid decline to IP values of almost zero comparing T0 and T3...
October 8, 2016: American Journal of Surgery
Camila Henriques Coelho, Adriana Oliveira Costa, Ana Carolina Carvalho Silva, Maíra Mazzoni Pucci, Angela Vieira Serufo, Haendel Goncalves Nogueira Oliveira Busatti, Maurício Durigan, Jonas Perales, Alex Chapeaurouge, Daniel Almeida da Silva E Silva, Maria Aparecida Gomes, Juliano Simões Toledo, Steven M Singer, Rosiane A Silva-Pereira, Ana Paula Fernandes
The zoonotic potential of giardiasis, as proposed by WHO since the late 70's, has been largely confirmed in this century. The genetic assemblages A and B of Giardia duodenalis are frequently isolated from human and canine hosts. Most of the assemblage A strains are not infective to adult mice, which can limit the range of studies regarding to biology of G. duodenalis, including virulence factors and the interaction with host immune system. This study aimed to determine the infectivity in mice of an assemblage A Giardia duodenalis strain (BHFC1) isolated from a dog and to classify the strain in sub-assemblages (AI, AII, AIII) through the phylogenetic analysis of beta-giardin (bg), triose phosphate isomerase (tpi) and glutamate dehydrogenase (gdh) genes...
2016: PloS One
Sérgio Monteiro de Almeida, Indianara Rotta, Arnaldo José de Conto, Dario Antonelli, Carlos Dabdoub Roda, Edna Yoshiko Yamada, Gisele M B Singer
Objective: To define how to best handle cerebrospinal fluid (CSF) specimens to obtain the highest positivity rate for the diagnosis of malignancy, comparing two different methods of cell concentration, sedimentation and cytocentrifugation. Methods: A retrospective analysis of 411 CSF reports. Results: This is a descriptive comparative study. The positive identification of malignant CSF cells was higher using the centrifuge than that using the Suta chamber (27...
October 2016: Arquivos de Neuro-psiquiatria
David Singer, Jacqueline E McLaughlin, Wendy C Cox
Objective. To assess the multiple mini-interview (MMI) as an admission tool for a satellite campus. Methods. In 2013, the MMI was implemented as part of a new admissions model at the UNC Eshelman School of Pharmacy. From fall 2013 to spring 2015, 73 candidates were interviewed by 15 raters on the satellite campus in Asheville, North Carolina. A many-facet Rasch measurement (MFRM) with three facets was used to determine the variance in candidate ratings attributable to rater severity, candidate ability, and station difficulty...
September 25, 2016: American Journal of Pharmaceutical Education
Matthias Echternach, Fabian Burk, Michael Burdumy, Christian T Herbst, Marie Köberlein, Michael Döllinger, Bernhard Richter
OBJECTIVES/HYPOTHESIS: In professional classical singing, an even voice quality throughout the entire singing voice range is essential. Transitions between vocal registers (passaggio) are the technically most challenging aspects in classical singing. It is hypothesized that they are most affected by vocal fold mass lesions (VFML). STUDY DESIGN: Cohort study. METHODS: In this study, the effect of VFML on vocal fold vibration in the passaggio regions was analyzed in four female and three male singers suffering from organic dysphonia...
October 18, 2016: Laryngoscope
Adam J Singer, Eric J Morley, Haney Mallemat
No abstract text is available yet for this article.
September 2016: Clin Exp Emerg Med
Adam J Singer, Henry C Thode, W Frank Peacock
OBJECTIVE: Introduction of target specific anticoagulants and recent guidelines encourage outpatient management of low risk patients with venous thromboembolism. We describe hospital admission rates over time for patients presenting to US emergency departments (EDs) with deep vein thrombosis (DVT) and pulmonary embolism (PE) and estimate the proportion of low-risk PE patients who could potentially be managed as outpatients. METHODS: We performed a structured analysis of the National Hospital Ambulatory Medical Care Survey (a nationally representative weighted sampling of US ED visits) database for the years 2006-2010 including all adult patients with a primary diagnosis of DVT or PE...
September 2016: Clin Exp Emerg Med
Janice H C Plani-Lam, Neli S Slavova-Azmanova, Nicole Kucera, Alison Louw, Jiulia Satiaputra, Peter Singer, Kong-Peng Lam, Margaret L Hibbs, Evan Ingley
No abstract text is available yet for this article.
October 14, 2016: Experimental Hematology
E Mark Mahone, Deana Crocetti, Laura Tochen, Tina Kline, Stewart H Mostofsky, Harvey S Singer
BACKGROUND: Complex motor stereotypies in children are repetitive rhythmic movements that have a predictable pattern and location, seem purposeful, but serve no obvious function, tend to be prolonged, and stop with distraction, e.g., arm or hand flapping, waving. They occur in both "primary" (otherwise typically developing) and secondary conditions. These movements are best defined as habitual behaviors and therefore pathophysiologically hypothesized to reside in premotor to posterior putamen circuits...
September 8, 2016: Pediatric Neurology
Anahita Javaheri, Tobias Kruse, Kristof Moonens, Raquel Mejías-Luque, Ayla Debraekeleer, Carmen I Asche, Nicole Tegtmeyer, Behnam Kalali, Nina C Bach, Stephan A Sieber, Darryl J Hill, Verena Königer, Christof R Hauck, Roman Moskalenko, Rainer Haas, Dirk H Busch, Esther Klaile, Hortense Slevogt, Alexej Schmidt, Steffen Backert, Han Remaut, Bernhard B Singer, Markus Gerhard
Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of H. pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H. pylori binding induces CEACAM1-mediated signalling, and the HopQ-CEACAM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the release of pro-inflammatory mediators such as interleukin-8...
October 17, 2016: Nature Microbiology
Parth K Modi, Eric A Singer, Evita T Sadimin
No abstract text is available yet for this article.
October 13, 2016: Journal of Urology
J Keszte, H Danker, A Dietz, E Meister, F Pabst, O Guntinas-Lichius, J Oeken, S Singer, A Meyer
In a German multi-center prospective cohort study, we wanted to assess the course of psychiatric comorbidity, utilization of mental health care and psychosocial care needs in laryngeal cancer patients during the first year after partial laryngectomy (PRL). Structured interviews with patients were conducted before surgery, 1 week (1 w), 3 months (3 m) and 1 year (12 m) after PRL. Psychiatric comorbidity was assessed using the Structured Clinical Interview for DSM-IV (SCID). Psychosocial care needs and utilization of mental health care were evaluated with standardized face-to-face interviews...
October 15, 2016: European Archives of Oto-rhino-laryngology
Jonathan P Singer, Patricia P Katz, Allison Soong, Pavan Shrestha, Debbie Huang, Jennifer Ho, Malori Mindo, John R Greenland, Steven R Hays, Jeffrey Golden, Jasleen Kukreja, Mary Ellen Kleinhenz, Rupal J Shah, Paul D Blanc
Under the U.S. Lung Allocation Score (LAS) system, older and sicker patients are prioritized for lung transplantation (LT). The impact of these changes on health-related quality of life (HRQL) after transplant has not been determined. In a single-center prospective cohort study, from 2010-2016 we assessed HRQL before and repeatedly after LT for up to 3 years using the SF12-Physical and Mental Health, the respiratory-specific Airway Questionnaire 20-Revised, and the Euroqol 5D/Visual Analog Scale utility measures by multivariate linear mixed models jointly modeled with death...
October 15, 2016: American Journal of Transplantation
Monica Jain, David L Krasne, Frederick R Singer, Armando E Giuliano
Parathyromatosis is a rare condition consisting of multiple nodules of benign hyperfunctioning parathyroid tissue scattered throughout the neck and superior mediastinum. As a potential cause of recurrent or persistent hyperparathyroidism, parathyromatosis is a challenging condition to diagnose and treat. The optimal evaluation and management of patients with parathyromatosis is not well established. The reported case involves a patient who was initially diagnosed with primary hyperparathyroidism. The diagnosis of Type 1 parathyromatosis was made after the patient developed recurrent hyperparathyroidism with hypercalcemia and osteoporosis 17 years after the initial operation and underwent two additional operations...
October 14, 2016: Endocrine
Manuj Yadav, Densil Cabrera
OBJECTIVES: This paper aims to study the effect of room acoustics and phonemes on the perception of loudness of one's own voice (autophonic loudness) for a group of trained singers. METHODS: For a set of five phonemes, 20 singers vocalized over several autophonic loudness ratios, while maintaining pitch constancy over extreme voice levels, within five simulated rooms. RESULTS: There were statistically significant differences in the slope of the autophonic loudness function (logarithm of autophonic loudness as a function of voice sound pressure level) for the five phonemes, with slopes ranging from 1...
October 11, 2016: Journal of Voice: Official Journal of the Voice Foundation
William S Duke, F Christopher Holsinger, Emad Kandil, Jeremy D Richmon, Michael C Singer, David J Terris
BACKGROUND: Robotic facelift thyroidectomy (RFT) was developed as a new surgical approach to the thyroid gland using a remote incision site. Early favorable results led to this confirmatory multi-institutional experience. METHODS: Prospectively collected data on consecutive patients undergoing RFT in five North American academic endocrine surgical practices were compiled. Surgical indications, operative times, final pathology, nodule size, complications, and postoperative management (drain use and length of hospital stay) were evaluated...
October 13, 2016: World Journal of Surgery
Sibylla Wolter, Carolin Dudschig, Barbara Kaup
This study explored differences between pianists and non-musicians during reading of sentences describing high- or low-pitched auditory events. Based on the embodied model of language comprehension, it was hypothesized that the experience of playing the piano encourages a corresponding association between high-pitched sounds and the right and low-pitched sounds and the left. This pitch-space association is assumed to become elicited during understanding of sentences describing either a high- or low-pitched auditory event...
October 12, 2016: Psychological Research
Karin Schindler, Michael Themessl-Huber, Michael Hiesmayr, Sigrid Kosak, Mitja Lainscak, Alessandro Laviano, Olle Ljungqvist, Mohamed Mouhieddine, Stéphane Schneider, Marian de van der Schueren, Tatjana Schütz, Christian Schuh, Pierre Singer, Peter Bauer, Claude Pichard
BACKGROUND: Inadequate nutrition during hospitalization is strongly associated with poor patient outcome, but ensuring adequate food intake is not a priority in clinical routine worldwide. This lack of priority results in inadequate and unbalanced food intake in patients and huge amounts of wasted food. OBJECTIVES: We evaluate the main factors that are associated with reduced meal intake in hospitalized patients and the differences between geographical regions. DESIGN: We conducted a descriptive analysis of data from 9 consecutive, annual, and cross-sectional nutritionDay samples (2006-2014) in a total of 91,245 adult patients in 6668 wards in 2584 hospitals in 56 countries...
October 12, 2016: American Journal of Clinical Nutrition
Elisa Damiani, Alex Dyson, Lucia Zacchetti, Abele Donati, Mervyn Singer
BACKGROUND: Hypoxemia may compromise cell metabolism and organ function. Supplemental oxygen (O2) at high concentrations may prove ineffective, and issues relating to hyperoxia, barotrauma, mechanical ventilation, and extracorporeal oxygenation are well documented. Old reports suggest the potential safety and efficacy of alternative routes for O2 administration, such as intravenous or intestinal. We re-explored these routes in rat models of hypoxemia. METHODS: Hypoxemia was induced in spontaneously breathing, anesthetized rats by breathing a hypoxic gas mix (FiO2 0...
December 2016: Intensive Care Medicine Experimental
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