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https://www.readbyqxmd.com/read/29789718/pdlim7-and-cdh18-regulate-the-turnover-of-mdm2-during-cdk4-6-inhibitor-therapy-induced-senescence
#1
Mary E Klein, Mark A Dickson, Cristina Antonescu, Li-Xuan Qin, Scott J Dooley, Afsar Barlas, Katia Manova, Gary K Schwartz, Aimee M Crago, Samuel Singer, Andrew Koff, William D Tap
CDK4/6 inhibitors are being used to treat a variety of human malignancies. In well-differentiated and dedifferentiated liposarcoma their clinical promise is associated with their ability to downregulate the MDM2 protein. The downregulation of MDM2 following treatment with CDK4/6 inhibitors also induces many cultured tumor cell lines derived from different types of malignancies to progress from quiescence into senescence. Here we used cultured human cell lines and defined a role for PDLIM7 and CDH18, regulating MDM2 protein in CDK4/6 inhibitor-treated cells...
May 23, 2018: Oncogene
https://www.readbyqxmd.com/read/29788350/relationship-among-team-dynamics-care-coordination-and-perception-of-safety-culture-in-primary-care
#2
Karen J Blumenthal, Alyna T Chien, Sara J Singer
Background: There remains a need to improve patient safety in primary care settings. Studies have demonstrated that creating high-performing teams can improve patient safety and encourage a safety culture within hospital settings, but little is known about this relationship in primary care. Objective: To examine how team dynamics relate to perceptions of safety culture in primary care and whether care coordination plays an intermediating role. Research Design: This is a cross-sectional survey study with 63% response (n = 1082)...
May 18, 2018: Family Practice
https://www.readbyqxmd.com/read/29785143/pilot-study-of-the-antifibrotic-effects-of-the-multikinase-inhibitor-pacritinib-in-a-mouse-model-of-liver-fibrosis
#3
Suliman Al-Fayoumi, Taishi Hashiguchi, Yuka Shirakata, John Mascarenhas, Jack W Singer
Background: Fibrotic diseases result from an exuberant response to chronic inflammation. Myelofibrosis is the end result of inflammation in bone, caused by an inflammatory process triggered by production of abnormal myeloid cells driven by mutations affecting the JAK-STAT pathway. Inflammatory cytokine overproduction leads to increased mesenchymal cell proliferation, culminating in fibrosis. Although JAK2 inhibitors, such as the JAK1/2 inhibitor ruxolitinib and the JAK2/FLT3/CSF1R/IRAK1 inhibitor pacritinib suppress abnormal clone expansion in myelofibrosis, ruxolitinib does not appear to prevent or reverse bone-marrow fibrosis in most patients...
2018: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/29784818/acoustic-evolution-of-old-italian-violins-from-amati-to-stradivari
#4
Hwan-Ching Tai, Yen-Ping Shen, Jer-Horng Lin, Dai-Ting Chung
The shape and design of the modern violin are largely influenced by two makers from Cremona, Italy: The instrument was invented by Andrea Amati and then improved by Antonio Stradivari. Although the construction methods of Amati and Stradivari have been carefully examined, the underlying acoustic qualities which contribute to their popularity are little understood. According to Geminiani, a Baroque violinist, the ideal violin tone should "rival the most perfect human voice." To investigate whether Amati and Stradivari violins produce voice-like features, we recorded the scales of 15 antique Italian violins as well as male and female singers...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29779542/improving-data-for-behavioral-health-workforce-planning-development-of-a-minimum-data-set
#5
Angela J Beck, Phillip M Singer, Jessica Buche, Ronald W Manderscheid, Peter Buerhaus
The behavioral health workforce, which encompasses a broad range of professions providing prevention, treatment, and rehabilitation services for mental health conditions and substance use disorders, is in the midst of what is considered by many to be a workforce crisis. The workforce shortage can be attributed to both insufficient numbers and maldistribution of workers, leaving some communities with no behavioral health providers. In addition, demand for behavioral health services has increased more rapidly as a result of federal legislation over the past decade supporting mental health and substance use parity and by healthcare reform...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779261/better-diet-quality-is-associated-with-lower-odds-of-severe-periodontitis-in-us-hispanics-latinos
#6
Christian R Salazar, Nadia Laniado, Yasmin Mossavar-Rahmani, Luisa N Borrell, Qibin Qi, Daniela Sotres-Alvarez, Douglas E Morse, Richard H Singer, Robert C Kaplan, Victor Badner, Ira B Lamster
AIM: We investigated the cross-sectional association between diet quality and severe periodontitis in a sample of diverse Hispanics from the Hispanic Community Health Study/Study of Latinos. MATERIALS AND METHODS: A total of 13,920 Hispanic/Latinos aged 18-74 years of different heritages underwent a full-mouth oral examination and completed two 24hr dietary recalls during 2008-2011. Severe periodontitis was defined as having ≥30% tooth sites with clinical attachment loss ≥ 5mm...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29778327/an-unusual-etiology-of-vocal-tremor-in-a-professional-singer
#7
REVIEW
Bridget L Hopewell, Cristen Paige, David O Francis
Vocal tremor is a neurologic disorder with myriad etiologies (eg, Parkinson disease, medications, or essential tremor). Vocal tremor can limit intelligibility and social interaction and can result in isolation in nonprofessional voice users. In a professional singer whose entire career is based on voice quality, onset of a vocal tremor is devastating. We report a case of sudden-onset vocal tremor that impeded a young professional singer's ability to perform and record her album. The etiology was determined to be a medication side effect of lamotrigine; a reaction that has not been previously reported...
May 16, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29776694/predictive-equations-versus-measured-energy-expenditure-by-indirect-calorimetry-a-retrospective-validation
#8
Oren Zusman, Ilya Kagan, Itai Bendavid, Miriam Theilla, Jonathan Cohen, Pierre Singer
BACKGROUND & AIMS: Measuring resting energy expenditure (REE) via indirect calorimetry (IC) in intensive care unit (ICU) patient is the gold standard recommended by guidelines. However technical difficulties hinder its use and predictive equations are largely used instead. We sought to validate commonly used equations using a large cohort of patients. METHODS: Patients hospitalized from 2003 to 2015 in a 16-bed ICU at a university-affiliated, tertiary care hospital who had IC measurement to assess caloric targets were included...
May 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29776528/the-effect-of-a-gearshift-interlock-on-seat-belt-use-by-drivers-who-do-not-always-use-a-belt-and-its-acceptance-among-those-who-do
#9
David G Kidd, Jeremiah Singer, Richard Huey, Laura Kerfoot
INTRODUCTION: Seat belts reduce the risk of fatal injury in a crash, yet in 2015, nearly 10,000 people killed in passenger vehicles were unrestrained. Enhanced seat belt reminders increase belt use, but a gearshift interlock that prevents the vehicle from being placed into gear unless the seat belt is used may prove more effective. METHOD: Thirty-two people with a recent seat belt citation and who admitted to not always using a seat belt as a driver were recruited as part-time belt users and asked to evaluate two new vehicles...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29774471/age-at-first-full-term-birth-and-breast-cancer-risk-in-brca1-and-brca2-mutation-carriers
#10
Joanne Kotsopoulos, Jacek Gronwald, Henry T Lynch, Andrea Eisen, Susan L Neuhausen, Nadine Tung, Peter Ainsworth, Jeffrey N Weitzel, Tuya Pal, William D Foulkes, Charis Eng, Christian F Singer, Leigha Senter, Ping Sun, Jan Lubinski, Steven A Narod
PURPOSE: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case-control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. METHODS: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire...
May 17, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29773241/introduction-what-works-and-for-whom
#11
EDITORIAL
Ralph I Horwitz, Burton Singer
No abstract text is available yet for this article.
May 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29771169/associations-between-skin-rash-treatment-outcome-and-single-nucleotide-polymorphisms-in-head-and-neck-cancer-patients-receiving-the-egfr-inhibitor-zalutumumab-results-from-the-dahanca-19-trial
#12
Line Brøndum, Jan Alsner, Brita Singers Sørensen, Christian Maare, Jørgen Johansen, Hanne Primdahl, Jan Folkvard Evensen, Claus Andrup Kristensen, Lisbeth Juhler Andersen, Jens Overgaard, Jesper Grau Eriksen
PURPOSE: To study the associations between development of moderate to severe skin rash, clinical outcome, and single nucleotide polymorphisms (SNPs) in candidate genes in head and neck cancer patients from the DAHANCA 19 trial receiving the EGFR-inhibitor zalutumumab concurrently with radiation treatment. MATERIAL AND METHODS: 310 patients were included from the zalutumumab-arm of the DAHANCA 19 study. Nine SNPs in the candidate genes EGFR, EGF, AREG, FCGR2A, FCGR3A, and CCND1 were successfully determined in 294 patients...
May 17, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29767717/introduction-to-the-hot-topics-in-aesthetic-surgery-supplement
#13
Robert Singer, Jeffrey M Kenkel
No abstract text is available yet for this article.
May 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29764676/effect-of-plantarflexion-resistance-of-an-ankle-foot-orthosis-on-ankle-and-knee-joint-power-during-gait-in-individuals-post-stroke
#14
Toshiki Kobayashi, Michael S Orendurff, Madeline L Singer, Fan Gao, Grace Hunt, K Bo Foreman
Plantarflexion resistance of an ankle-foot orthosis (AFO) plays an important role to prevent foot-drop, but its impact on push-off has not been well investigated in individuals post-stroke. The aim of this study was to investigate the effect of plantarflexion resistance of an articulated AFO on ankle and knee joint power of the limb wearing the AFO in individuals post-stroke. Gait analysis was performed on 10 individuals with chronic stroke using a Vicon 3-dimensional motion capture system and a Bertec split-belt instrumented treadmill...
May 5, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29762252/high-intensity-interval-or-continuous-moderate-exercise-a-24-week-pilot-trial
#15
Sean R Locke, Jessica E Bourne, Mark R Beauchamp, Jonathan P Little, Julianne Barry, Joel Singer, Mary E Jung
PURPOSE: High-intensity interval training (HIIT) may lead to superior cardiometabolic improvements when compared to moderate-intensity continuous training (MICT). However, adherence to HIIT requires examination. The purpose of this pilot study was to examine moderate-to-vigorous physical activity (MVPA) adherence 24 weeks following a brief counselling intervention combined with either HIIT or MICT. METHODS: Individuals at high risk of type 2 diabetes (T2D) were randomized to HIIT (n = 15) or MICT (n = 17) and completed 10 exercise sessions accompanied by a brief 10-minute counselling intervention over a 2-week period...
May 14, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29761591/psychological-distress-in-lung-cancer-survivors-at-least-one-year-after-diagnosis-results-of-a-german-multicenter-cross-sectional-study
#16
Martin Eichler, Marlene Hechtner, Beatrice Wehler, Roland Buhl, Jan Stratmann, Martin Sebastian, Heinz Schmidberger, Jessica Peuser, Cornelius Kortsik, Ursula Nestle, Sebastian Wiesemann, Hubert Wirtz, Thomas Wehler, Maria Blettner, Susanne Singer
OBJECTIVE: Despite the high incidence of lung cancer, little is known about distress in lung cancer survivors and patients who have survived diagnose for at least one year. We investigated distress prevalence and associated factors. METHODS: We performed a multicenter (n=6 hospitals) cross-sectional study. Data were collected using medical records, questionnaires, and a telephone interview. Distress was measured with the Patient Health Questionnaire (PHQ-4). Odds ratios (OR) for factors potentially associated with distress were calculated using multivariable logistic regression...
May 14, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29759976/missed-opportunities-for-prevention-of-vertical-hiv-transmission-in-canada-1997-2016-a-surveillance-study
#17
Ari Bitnun, Terry Lee, Jason Brophy, Lindy M Samson, Fatima Kakkar, Wendy Vaudry, Ben Tan, Deborah M Money, Joel Singer, Laura J Sauvé, Ariane Alimenti
BACKGROUND: Vertical HIV transmission has declined in Canada, but missed opportunities for prevention continue to occur. We sought to determine the adequacy, and changes over time in adequacy, of uptake of maternal and neonatal antiretroviral therapy for the prevention of vertical HIV transmission, and to determine the vertical transmission rate over time and according to adequacy of antenatal antiretroviral therapy during the combination antiretroviral therapy era in Canada. METHODS: The Canadian Perinatal HIV Surveillance Program collects data annually through retrospective chart review concerning HIV-infected women and their infants...
May 10, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29759380/impact-of-a-clinical-interventions-bundle-on-uptake-of-hpv-vaccine-at-an-ob-gyn-clinic
#18
Uma Deshmukh, Carlos R Oliveira, Susan Griggs, Emily Coleman, Lital Avni-Singer, Shefali Pathy, Eugene D Shapiro, Sangini S Sheth
INTRODUCTION: HPV vaccine uptake is lowest among young adults. Little is known about the most effective way to decrease missed opportunities (MO) and increase uptake of the vaccine in this vulnerable population. OBJECTIVES: To determine the impact of a clinical intervention bundle on the rate of MO and uptake of the vaccine among young adult women. METHODS: From 2/2014 to 7/2015, an intervention bundle (designating physician and nurse champions, pre-screening patients' charts, empowering nurses to recommend immunization, providing no-cost vaccinations, placing prompts in clinic note templates, eliminating requirement for pre-vaccination pregnancy test) was implemented at an urban, hospital-based OB/GYN clinic...
May 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29757489/emergency-department-discharge-of-pulmonary-embolus-patients
#19
W Frank Peacock, Craig I Coleman, Deborah Diercks, Samuel Francis, Christopher Kabrhel, Catherine Keay, Jeffery Kline, Jacob Manteuffel, Peter Wildgoose, Jim Xiang, Adam J Singer
BACKGROUND: Hospitalization for low risk pulmonary embolism (PE) is common, expensive, and of questionable benefit. OBJECTIVE: Determine if low-risk PE patients discharged from the emergency department (ED) on rivaroxaban require fewer hospital days compared to standard of care (SOC). METHODS: Multicenter, open label randomized trial in low risk PE defined by Hestia criteria. Adult subjects were randomized to early ED discharge on rivaroxaban, or SOC...
May 14, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29757080/singing-for-lung-health-service-evaluation-of-the-british-lung-foundation-programme
#20
A Lewis, P Cave, N S Hopkinson
AIMS: Singing for Lung Health (SLH) is a novel intervention for individuals with respiratory disease. Qualitative results suggest benefits to physical, mental and emotional health. Limited data also suggest objective improvements in measures of quality of life with SLH are achievable. It is not known how effective the SLH groups supported by the British Lung Foundation (BLF) in the UK are. The objective was to understand the clinical impact SLH has on individuals with respiratory disease...
May 1, 2018: Perspectives in Public Health
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