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https://www.readbyqxmd.com/read/28545072/effect-of-vitamin-d-on-endothelial-progenitor-cells-function
#1
Yoav Hammer, Alissa Soudry, Amos Levi, Yeela Talmor-Barkan, Dorit Leshem-Lev, Joel Singer, Ran Kornowski, Eli I Lev
BACKGROUND: Endothelial progenitor cells (EPCs) are a population of bone marrow-derived cells, which have an important role in the process of endothelialization and vascular repair following injury. Impairment of EPCs, which occurs in patients with diabetes, was shown to be related to endothelial dysfunction, coronary artery disease (CAD) and adverse clinical outcomes. Recent evidence has shown that calcitriol, the active hormone of vitamin D, has a favorable impact on the endothelium and cardiovascular system...
2017: PloS One
https://www.readbyqxmd.com/read/28544158/molecular-and-physiological-manifestations-and-measurement-of-aging-in-humans
#2
REVIEW
Sadiya S Khan, Benjamin D Singer, Douglas E Vaughan
Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in response to stress (termed homeostenosis) and a time-dependent failure of complex molecular mechanisms that cumulatively create disorder. Aging inevitably occurs with time in all organisms and emerges on a molecular, cellular, organ, and organismal level with genetic, epigenetic, and environmental modulators. Individuals with the same chronological age exhibit differential trajectories of age-related decline, and it follows that we should assess biological age distinctly from chronological age...
May 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/28542336/does-ngal-reduce-costs-a-cost-analysis-of-urine-ngal-ungal-serum-creatinine-scr-for-acute-kidney-injury-aki-diagnosis
#3
Amay Parikh, John A Rizzo, Pietro Canetta, Catherine Forster, Meghan Sise, Omar Maarouf, Eugenia Singer, Antje Elger, Saban Elitok, Kai Schmidt-Ott, Jonathon Barasch, Thomas L Nickolas
INTRODUCTION: Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a sensitive and specific diagnostic test for acute kidney injury (AKI) in the Emergency Department (ED), but its economic impact has not been investigated. We hypothesized that uNGAL used in combination with serum creatinine (sCr) would reduce costs in the management of AKI in patients presenting to the ED in comparison to using sCr alone. MATERIALS AND METHODS: A cost simulation model was developed for clinical algorithms to diagnose AKI based on sCr alone vs...
2017: PloS One
https://www.readbyqxmd.com/read/28540334/integrin-alpha10-drives-tumorigenesis-in-sarcoma
#4
EDITORIAL
Tomoyo Okada, Samuel Singer
No abstract text is available yet for this article.
March 2017: Oncoscience
https://www.readbyqxmd.com/read/28536719/insulin-bolus-calculator-in-a-pediatric-hospital-safety-and-user-perceptions
#5
Mohammad B Ateya, Ranjit Aiyagari, Colleen Moran, Kanakadurga Singer
BACKGROUND: Insulin dosing in hospitalized pediatric patients is challenging and requires dosing to be matched with the specific clinical and nutritional circumstances. We implemented a customized subcutaneous insulin bolus dose calculator tool integrated with the electronic health record to improve patient care. Here we describe this tool, its utilization and safety, and assess user satisfaction and perceptions of the tool. METHODS: Blood glucose results for all patients who received insulin with and without the calculator tool were compared to assess safety...
May 24, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28536088/the-use-of-text-messaging-to-improve-the-hospital-to-community-transition-in-acute-coronary-syndrome-patients-txt2prevent-intervention-development-and-pilot-randomized-controlled-trial-protocol
#6
Emily S Ross, Brodie M Sakakibara, Martha H Mackay, David Gt Whitehurst, Joel Singer, Mustafa Toma, Kitty K Corbett, Harriette Gc Van Spall, Kimberly Rutherford, Bobby Gheorghiu, Jillianne Code, Scott A Lear
BACKGROUND: Acute coronary syndrome, including acute myocardial infarction (AMI), is one of the leading causes for hospitalization, with AMI 30-day readmission rates around 20%. Supporting patient information needs and increasing adherence to recommended self-management behaviors during transition from hospital to home has the potential to improve patient outcomes. Text messages have been effective in other interventions and may be suitable to provide support to patients during this transition period...
May 23, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28535315/early-career-outcomes-of-family-medicine-residency-graduates-exposed-to-innovative-flexible-longitudinal-tracks
#7
Richard A Young, Dan Casey, Diana Singer, Elaine Waller, Patricia A Carney
BACKGROUND AND OBJECTIVES: The Preparing the Personal Physician for Practice (P4) project used a case series design to study innovations in the content, length, structure, and location of residency training in 14 geographically diverse family medicine programs between 2007 and 2012. We aimed to explore how offering flexible longitudinal tracks (FLT) affected graduates' scope of practice, particularly in maternal child health (MCH), which included at least 17 months of focused training that increased each year over 4 years...
May 2017: Family Medicine
https://www.readbyqxmd.com/read/28533074/exercise-science-principles-and-the-vocal-warm-up-implications-for-singing-voice-pedagogy
#8
Matthew Hoch, Mary J Sandage
OBJECTIVES/HYPOTHESES: Principles from exercise science literature were applied to singing warm-up pedagogy as a method for examining parallels between athletic and voice training. Analysis of the use of exercise principles in vocal warm-up should illuminate aspects of voice training that may be further developed in the future. METHODS/DESIGN: A selected canon of standard voice pedagogy texts and well-regarded warm-up methods were evaluated for use of exercise science principles for skill acquisition and fatigue resistance...
May 19, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28532612/why-evidence-based-medicine-failed-in-patient-care-and-medicine-based-evidence-will-succeed
#9
Ralph I Horwitz, Burton H Singer
Evidence-based medicine (EBM) has succeeded in strengthening the evidence base for population medicine. Where EBM has failed is in answering the practicing doctor's question of what a likely outcome would be when a given treatment is administered to a particular patient with her own distinctive biological and biographical (life experience) profile. We propose Medicine-based evidence (MBE), based on the profiles of individual patients, as the evidence base for individualized or personalized medicine. MBE will build an archive of patient profiles using data from all study types and data sources, and will include both clinical and socio-behavioral information...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28527872/response-to-should-we-use-the-tetanus-quick-stick-in-the-emergency-department
#10
Patrick Olivieri, Taylor Miller, Elizabeth Singer
No abstract text is available yet for this article.
April 21, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28527007/factors-associated-with-supportive-care-needs-in-glioma-patients-in-the-neuro-oncological-outpatient-setting
#11
Mirjam Renovanz, Marlene Hechtner, Mareile Janko, Karoline Kohlmann, Jan Coburger, Minou Nadji-Ohl, Jochem König, Florian Ringel, Susanne Singer, Anne-Katrin Hickmann
Objective of this study aimed at assessing glioma patients' supportive care needs in a neurosurgical outpatient setting and identifying factors that are associated with needs for support. In three neuro-oncological outpatient departments, glioma patients were assessed for their psychosocial needs using the Supportive Care Needs Survey short-form (SCNS-SF34-G). Associations between clinical, sociodemographic, treatment related factors as well as distress (measured with the distress thermometer) and supportive care needs were explored using multivariable general linear models...
May 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28526254/associations-between-midlife-insomnia-symptoms-and-earlier-retirement
#12
Lauren Hale, Lee Singer, Jodi H Barnet, Paul E Peppard, Erika W Hagen
BACKGROUND: Insomnia symptoms are prevalent and associated with impaired health and well-being. However, scant research has investigated whether midlife insomnia symptoms are also associated with earlier retirement, thereby contributing to additional economic consequences. PARTICIPANTS AND METHODS: We analyzed data from a community-based sample of 1635 Wisconsin State employees (51.6% women) that were collected from 1988 until 2014. Study participants were asked about insomnia symptoms (difficulty getting to sleep, difficulty getting back to sleep, repeated nocturnal awakenings, and early morning awakenings) in midlife, with prospective follow-up questions about the specific reasons for retirement between 2010 and 2014...
June 2017: Sleep Health
https://www.readbyqxmd.com/read/28526188/corrigendum-to-mesh-versus-acellular-dermal-matrix-in-immediate-implant-based-breast-reconstruction-a-prospective-randomized-trial-eur-j-surg-oncol-42-5-2016-665-671
#13
D Gschwantler-Kaulich, P Schrenk, V Bjelic-Radisic, K Unterrieder, C Leser, A Fink-Retter, M Salama, C Singer
No abstract text is available yet for this article.
May 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28521716/building-a-successful-military-to-military-partnership-through-confronting-hiv-the-u-s-nigeria-experience
#14
Aladdin Shadyab, Darrell Singer, Lindsay Hughes, Robbie Nelson, Tahir Umar, Ogbonnaya Simon Njoku
The Nigerian Ministry of Defence-Walter Reed Army Institute of Research partnership was established in 2004 in response to the growing HIV/AIDS epidemic in Nigeria. Here we discuss the emergence of HIV in Nigeria, highlighting the initial barriers to treatment delivery, and outline the origins of the international military-to-military partnership developed to confront the disease. With financial support from the United States President's Plan for AIDS Relief and Nigerian Government Counterpart Funding, we demonstrate how this program led to a successful and sustainable response in the fight against HIV in Nigeria...
May 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28514694/the-association-of-prenatal-cocaine-exposure-externalizing-behavior-and-adolescent-substance-use
#15
Sonia Minnes, Meeyoung O Min, June-Yung Kim, Meredith W Francis, Adelaide Lang, Miaoping Wu, Lynn T Singer
Prenatal cocaine exposure (PCE) may increase adolescent substance use through alterations of neurotransmitter systems affecting fetal brain development. The relationship between PCE and substance use at 15 and 17 years was examined. Subjects (365: 186 PCE; 179 non-cocaine exposed (NCE)) supplied biologic and self-report data using the Youth Risk Behavior Surveillance System (YRBSS) and Computerized Diagnostic Interview Schedule for Children (C-DISC 4) at ages 15 and 17. The relationship between PCE and substance use was assessed using General Estimating Equation (GEE) analyses controlling for confounding factors including violence exposure and preschool lead level...
March 24, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28510717/fast-population-growth-in-physogastry-reproduction-of-luciaphorus-perniciosus-acari-pygmephoridae-at-different-temperatures
#16
Prapassorn Bussaman, Chirayu Sa-Uth, Angsumarn Chandrapatya, Remzi Atlihan, Ayhan Gökçe, Pavel Saska, Hsin Chi
Luciaphorus perniciosus Rack is one of the most serious pests of several cultivated mushroom species including Ganoderma lucidum (Fr.), Flammulina velutipes Karst., Auricularia polytricha (Mont.) Saac., Lentinus polychrous Lev., and Lentinus squarrosulus (Mont.) Singer in Thailand. Adult female Lu. perniciosus produce offspring inside their physogastric hysterosomas, with all embryos developing through to the adult stage while remaining in the abdomen. Once the abdomen ruptures, the female parent dies and the offspring consisting of mostly fertilized female adults along with a few male adults continue to emerge from the cadaver of the mother for a period of several days...
May 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28510097/ago-austria-recommendation-on-screening-and-diagnosis-of-lynch-syndrome-ls
#17
Alain G Zeimet, Harald Mori, Edgar Petru, Stephan Polterauer, Alexander Reinthaller, Christian Schauer, Tonja Scholl-Firon, Christian Singer, Katharina Wimmer, Johannes Zschocke, Christian Marth
PURPOSE: This manuscript reports the consensus recommendations on screening and diagnosis of Lynch syndrome (LS) in patients with endometrial or ovarian cancer as well as on possible preventive measures in effectively LS-diagnosed women. The recommendations are issued by the Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO) of the Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) after consultation of the most recent and relevant literature and following deliberation by the Genetic Task-Force convoked May, 2015 by the AGO Council...
May 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28506806/selective-associative-phonagnosia-after-right-anterior-temporal-stroke
#18
Simona Luzzi, Michela Coccia, Gabriele Polonara, Carlo Reverberi, Gabriella Ceravolo, Mauro Silvestrini, Fabio Fringuelli, Sara Baldinelli, Leandro Provinciali, Guido Gainotti
We report the case of a 48 year old men who developed a selective impairment in famous voice recognition after ischemic stroke in right subcortical structures (lenticular nucleus and head of the caudate) and right anterior temporal lobe. He underwent fibrinolytic treatment. During the following days he progressively recovered and was discharged without neurological focal sign. Patent foramen ovale was found. When he got back to his house he noticed that he was unable to recognize the voice of his favoured singers and needed to ask who was the singer to his relatives...
May 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28506500/autonomic-and-electrocardiographic-findings-in-parkinson-s-disease
#19
Christopher H Gibbons, David K Simon, Meilin Huang, Barbara Tilley, Michael J Aminoff, Jacquelyn L Bainbridge, Matthew Brodsky, Roy Freeman, John Goudreau, Robert W Hamill, Sheng T Luo, Carlos Singer, Aleksandar Videnovic, Ivan Bodis-Wollner, Pei S Wong
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms and signs. Many reports suggest that diminished heart rate variability occurs early, even prior to the cardinal signs of PD. In a longitudinal study of PD, we evaluated whether heart rate variability (HRV) obtained using a 10-second ECG tracing, and the electrocardiographic QT-interval would be associated with PD severity and progression. Subjects were derived from a longitudinal study of 1741 individuals with early, stable PD...
April 14, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28504905/antibiotics-for-sepsis-does-each-hour-really-count-or-is-it-incestuous-amplification
#20
Mervyn Singer
No abstract text is available yet for this article.
May 15, 2017: American Journal of Respiratory and Critical Care Medicine
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