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https://www.readbyqxmd.com/read/29037026/treatment-outcomes-of-extended-field-radiation-therapy-for-thoracic-superficial-esophageal-cancer
#1
Doo Yeul Lee, Sung Ho Moon, Kwan Ho Cho, Tae Hyun Kim, Moon Soo Kim, Jong Yeul Lee, Yang-Gun Suh
PURPOSE: To evaluate the efficacy and safety of extended-field radiation therapy for patients with thoracic superficial esophageal cancer (SEC). MATERIALS AND METHODS: From May 2007 to October 2016, a total of 24 patients with thoracic SEC (T1a and T1b) who underwent definitive radiotherapy and were analyzed retrospectively. The median total radiotherapy dose was 64 Gy (range, 54 to 66 Gy) in conventional fractionation. All 24 patients received radiotherapy to whole thoracic esophagus and 23 patients received elective nodal irradiation...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29036607/endoscopic-and-histopathologic-reflux-associated-mucosal-damage-in-the-remnant-esophagus-following-transthoracic-esophagectomy-for-cancer-5-year-long-term-follow-up
#2
H F Fuchs, H M Schmidt, M Meissner, S Brinkmann, M Maus, M Bludau, W Schröder, A H Hölscher, J M Leers
Gastroesophageal reflux is a common problem following esophagectomy and reconstruction with gastric interposition. Despite a routine prescription of proton pump inhibitors, reflux-associated mucosal damage in the remnant esophagus is frequently observed. Purpose of this study is to evaluate mucosal damage in the esophageal remnant during long-term follow-up and to compare the prevalence of this damage between the subgroups of esophageal squamous cell and adenocarcinoma. All patients undergoing transthoracic Ivor-Lewis esophagectomy were prospectively entered in our IRB approved database...
September 21, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036528/prediction-of-pathologic-responders-to-neoadjuvant-chemoradiotherapy-by-diffusion-weighted-magnetic-resonance-imaging-in-locally-advanced-esophageal-squamous-cell-carcinoma-a-prospective-study
#3
Q-W Li, B Qiu, B Wang, D-L Wang, S-H Yin, H Yang, J-L Liu, J-H Fu, M-Z Liu, C-M Xie, H Liu
This study aims to investigate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in ESCC patients receiving neoadjuvant concurrent chemoradiotherapy (CCRT), and the efficacy of apparent diffusion coefficient (ADC) values in predicting pathologic response to neoadjuvant CCRT. Twenty-eight locally advanced ESCC patients treated with neoadjuvant CCRT followed by radical resection were prospectively enrolled. DW-MRI was recommended to be performed within 2 weeks before and 4-6 weeks after neoadjuvant CCRT...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036431/longitudinal-outcomes-of-radiofrequency-ablation-versus-surveillance-endoscopy-for-barrett-s-esophagus-with-low-grade-dysplasia
#4
A Kahn, M Al-Qaisi, V T Kommineni, J K Callaway, E S Boroff, G E Burdick, D M Lam-Himlin, M Temkit, M F Vela, F C Ramirez
Radiofrequency ablation of Barrett's esophagus with low-grade dysplasia is recommended in recent American College of Gastroenterology guidelines, with endoscopic surveillance considered a reasonable alternative. Few studies have directly compared outcomes of radiofrequency ablation to surveillance and those that have are limited by short duration of follow-up. This study aims to compare the long-term effectiveness of radiofrequency ablation versus endoscopic surveillance in a large, longitudinal cohort of patients with Barrett's esophagus, and low-grade dysplasia...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036407/prognostic-value-of-the-circumferential-resection-margin-and-its-definitions-in-esophageal-cancer-patients-after-neoadjuvant-chemoradiotherapy
#5
L Depypere, J Moons, T Lerut, G De Hertogh, C Peters, X Sagaert, W Coosemans, H Van Veer, P Nafteux
The accepted importance of a positive circumferential resection margin (CRM) (defined as R1 in the TNM classification) is based on histopathology of the resection specimen obtained after primary surgery in esophageal cancer patients. The aim of this study is to look for the prognostic value of CRM after neoadjuvant chemoradiotherapy and to compare the clinical significance of a histologically CRM < 1 mm from the cut margin (Royal College of Pathologists definition of R1) to a positive cut margin (College of American Pathologists definition of R1) and to ≥1 mm margin (R0) resections in patients with ypT3-esophageal tumors after neoadjuvant chemoradiotherapy...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036278/perceptions-of-risk-and-therapy-among-patients-with-barrett-s-esophagus-a-patient-survey-study
#6
M W Stier, N Lodhia, J Jacobs, D Nozicka, R Kavitt, U Siddiqui, I Waxman, V J Konda
Nondysplastic Barrett's esophagus has a risk of progression to esophageal adenocarcinoma as low as 0.18-0.3% per person per year, and low-grade dysplasia as low as 0.5%. While adherence to guidelines and selection of management options varies, little is known about what modifies patient decision-making. This study aims to evaluate and identify factors that influence patient perceptions of risk and decisions about management. An independently developed and piloted survey was administered to patients at an academic hospital...
September 21, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29034995/mir-1-suppresses-the-proliferation-and-promotes-the-apoptosis-of-esophageal-carcinoma-cells-by-targeting-src
#7
Zhicong Liao, Xiaojun Wang, Hongwei Liang, Ao Yu, Uzair Ur Rehman, Qian Fan, Yue Hu, Chen Wang, Zhen Zhou, Tao Wang
Nonreceptor tyrosine kinase c-Src, also known as Src, is a potent oncogene involved in a series of biological processes including cell growth, differentiation, and apoptosis; however, its expression pattern and function in esophageal cancer is poorly addressed. In this study, abnormal overexpression of Src protein was observed in esophageal cancer tissues, which fuelled the speculation that microRNA-mediated posttranscriptional regulatory mechanism might be involved. Bioinformatic analyses were applied to identify miRNAs that could potentially target Src...
October 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29034656/guidelines-of-the-italian-society-of-videosurgery-in-infancy-for-the-minimally-invasive-treatment-of-the-esophageal-atresia
#8
Salvatore Fabio Chiarenza, Maria Luisa Conighi, Andrea Conforti, Ciro Esposito, Maria Escolino, Fabio Beretta, Maurizio Cheli, Vincenzo Di Benedetto, Maria Grazia Scuderi, Giovanni Casadio, Maurizio Marzaro, Leon Francesco Fascetti, Claudio Vella, Cosimo Bleve, Daniela Codric, Paolo Caione, Pietro Bagolan
Not available.
October 4, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/29034419/esophagitis-unrelated-to-reflux-disease-current-status-and-emerging-diagnostic-challenges
#9
Melanie E Johncilla, Amitabh Srivastava
There has been much progress in our understanding of esophageal inflammatory disorders in the past few years. This is particularly true about esophageal eosinophilia and PPI responsiveness, lymphocytic esophagitis and motility disorders, and short-term risk of neoplasia in esophageal leukoplakia. The current review will summarize esophageal injury patterns that primarily occur due to non-reflux causes, with a focus on usual pitfalls in biopsy diagnosis and recent advances in our knowledge of the more common forms of esophagitis...
October 15, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29034238/exploring-the-abnormal-modulation-of-the-autonomic-systems-during-nasal-flow-limitation-in-upper-airway-resistance-syndrome-by-hilbert-huang-transform
#10
Chen Lin, Men-Tzung Lo, Christian Guilleminault
Patients with nasal flow limitation and upper airway resistance syndrome (UARS) during sleep can present with low blood pressure and disturbing symptoms associated with hypervagotony. We hypothesized that the dynamic changes of the autonomic system related to inspiratory flow limitation can be quantified by the developed analytic technique applied on beat-to-beat heart rate (RR intervals) and finger photoplethysmography (PPG). METHOD: A breath-by-breath investigation based on the Hilbert-Huang transform was performed to explore autonomic nervous system changes observed during inspiratory flow limitation...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29034234/interleukin-13-in-asthma-and-other-eosinophilic-disorders
#11
Emma Doran, Fang Cai, Cécile T J Holweg, Kit Wong, Jochen Brumm, Joseph R Arron
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity, asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. While it is appreciated that eosinophilia is present in only a subset of patients, it remains a key feature of asthma and other eosinophilic disorders such as atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis with nasal polyps...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29034088/emerging-dilemmas-in-the-diagnosis-and-management-of-gastroesophageal-reflux-disease
#12
REVIEW
Peter Kahrilas, Rena Yadlapati, Sabine Roman
Gastroesophageal reflux disease (GERD) is common, but less so than widely reported because of inconsistencies in definition. In clinical practice, the diagnosis is usually based on a symptom assessment without testing, and the extent of diagnostic testing pursued should be limited to that which guides management or which protects the patient from the risks of a potentially morbid treatment or an undetected early (or imminent) esophageal adenocarcinoma or which does both. When testing is pursued, upper gastrointestinal endoscopy is the most useful initial diagnostic test because it evaluates for the major potential morbidities (Barrett's, stricture, and cancer) associated with GERD and facilitates the identification of some alternative diagnostic possibilities such as eosinophilic esophagitis...
2017: F1000Research
https://www.readbyqxmd.com/read/29033778/a-case-of-basaloid-squamous-cell-carcinoma-of-polypoid-type-in-the-esophagus
#13
Ki Hun Lee, Sang Jin Lee, Hak Soo Kim, Sung Eun Kim, Soo Yong Choi, Hyun Ju Lee, Suk Hun Ha, Kwang Hoon Oh, Dae-Woon Eom
Basaloid squamous cell carcinoma of the esophagus is very rare. Further, polypoid type of esophageal cancer is also rare. We have recently treated a case of basaloid squamous cell carcinoma which presented as a 1.3-cm esophageal polyp. A 48-year-old woman was referred to our hospital because of a polypoid mass at 36 cm distance from the upper incisor on endoscopic examination, and the result of the biopsy was basaloid squamous cell carcinoma. The patient underwent Ivor Lewis operation with lymph node dissection...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033774/hemothorax-following-uncomplicated-endoscopic-variceal-sclerotherapy-and-ligation-for-esophageal-varices
#14
Tomoko Ochiai, Yukiomi Nakade, Rena Kitano, Shunsuke Kato, Kazumasa Sakamoto, Tadahisa Inoue, Yuji Kobayashi, Norimitsu Ishii, Tomohiko Ohashi, Yoshio Sumida, Kiyoaki Ito, Haruhisa Nakao, Chihiro Furuta, Motoki Yano, Masashi Yoneda
Endoscopic variceal sclerotherapy and ligation are standard treatment modalities used for the management of esophageal varices. Reportedly, sclerotherapy and ligation are associated with complications such as hematuria, pulmonary thrombus formation, pleural effusion, renal dysfunction, and esophageal stenosis. However, hemothorax following sclerotherapy and ligation has not yet been reported. We treated a patient who presented with liver cirrhosis and polycythemia vera and later developed hemothorax following the above-mentioned procedures...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033756/progression-from-an-inflammatory-to-a-fibrostenotic-phenotype-in-eosinophilic-esophagitis
#15
Nathaniel T Koutlas, Evan S Dellon
Previous studies have suggested that eosinophilic esophagitis (EoE) progresses from chronic inflammation to fibrostenosis. However, natural history data illustrating this progression in individual patients are lacking. Here, we present 6 patients who progressed from an inflammatory to a fibrostenotic phenotype of EoE in the absence of treatment. At the time of diagnosis, none of the patients had significant evidence of fibrostenosis, but they did have other inflammatory findings of EoE such as edema, linear furrows, or exudates...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033729/use-of-rocuronium-and-sugammadex-under-neuromuscular-transmission-monitoring-in-a-patient-with-multiple-sclerosis
#16
Chryssoula Staikou, Martina Rekatsina
Multiple sclerosis (MS) is a potentially disabling disease characterized by demyelinating lesions in the central nervous system. One of the anesthetic challenges encountered in surgical patients with MS is the management of neuromuscular blockade (NMB) and its reversal. We report a case of a 31-year-old female patient suffering from MS, who underwent gynecological surgery under general anesthesia with sevoflurane, fentanyl, and rocuronium which was successfully reversed with sugammadex. Neuromuscular transmission (NMT) monitoring was used to guide the intraoperative doses of rocuronium and also the reversal of NMB by the use of sugammadex to ensure a safe tracheal extubation...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29033590/sitting-time-and-occupational-and-recreational-physical-activity-in-relation-to-the-risk-of-esophageal-squamous-cell-carcinoma
#17
Pengxiang Chen, Qingxu Song, Jie Han, Huapu Xu, Tong Chen, Jiaqi Xu, Yufeng Cheng
BACKGROUNDS: Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT) on ESCC risk. METHODS: Five hundred fifty-seven ESCC patients and 543 healthy controls matched by sex and age were recruited for this study. Conditional logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29033478/bayesian-variable-selection-for-a-semi-competing-risks-model-with-three-hazard-functions
#18
Andrew G Chapple, Marina Vannucci, Peter F Thall, Steven Lin
A variable selection procedure is developed for a semi-competing risks regression model with three hazard functions that uses spike-and-slab priors and stochastic search variable selection algorithms for posterior inference. A rule is devised for choosing the threshold on the marginal posterior probability of variable inclusion based on the Deviance Information Criterion (DIC) that is examined in a simulation study. The method is applied to data from esophageal cancer patients from the MD Anderson Cancer Center, Houston, TX, where the most important covariates are selected in each of the hazards of effusion, death before effusion, and death after effusion...
August 2017: Computational Statistics & Data Analysis
https://www.readbyqxmd.com/read/29033436/bullous-pemphigoid-presenting-with-esophagitis-dissecans-superficialis
#19
Kunimitsu Inoue, Tomoya Okajima, Osamu Okamoto, Kazunari Murakami
No abstract text is available yet for this article.
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29033183/the-overexpression-and-predictive-significance-of-mmp-12-in-esophageal-squamous-cell-carcinoma
#20
Fei Han, Suxia Zhang, Long Zhang, Qiongyu Hao
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor invasion and metastasis. MMP-12, as metalloelastase, its function in tumor progression remains contradictory. This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells...
September 28, 2017: Pathology, Research and Practice
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