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https://www.readbyqxmd.com/read/29667114/efficacy-of-endoscopic-ultrasonography-for-determining-clinical-t-category-for-esophageal-squamous-cell-carcinoma-data-from-1434-surgical-cases
#1
Jie Yang, Guang-Yu Luo, Run-Bin Liang, Tai-Shan Zeng, Hao Long, Jian-Hua Fu, Guo-Liang Xu, Mu-Zi Yang, Shuo Li, Lan-Jun Zhang, Peng Lin, Xin Wang, Xue Hou, Hao-Xian Yang
BACKGROUND: The efficacy of endoscopic ultrasonography (EUS) for determining T category is variable for esophageal squamous cell carcinoma (ESCC). We aimed to assess the efficacy of EUS in accurately identifying T category for ESCC based on the 8th AJCC Cancer Staging Manual. METHODS: A retrospective analysis was conducted using a prospectively collected ESCC database from January 2003 to December 2015, in which all patients underwent EUS examination followed by esophagectomy...
April 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29667054/connecting-gastrointestinal-cancer-risk-to-cadmium-and-lead-exposure-in-the-chaoshan-population-of-southeast-china
#2
Xueqiong Lin, Lin Peng, Xijin Xu, Yanrong Chen, Yuling Zhang, Xia Huo
Cadmium (Cd) and lead (Pb) pose a serious threat to human health because of its carcinogenicity. China ranks first according to the Global Cancer Report for 2014 in newly diagnosed gastrointestinal cancers and cancer deaths. The aim of the present study was to evaluate the association of Cd and Pb burden with the risk of gastrointestinal cancers in a hospital-based case-control study from southern regions of China, Chaoshan area. A total of 279 hospitalized patients were recruited in this study, of which 167 were gastrointestinal cancer cases (70 esophageal cancer, 51 gastric cancer, and 46 colorectal cancer), and 112 controls were recruited from two hospitals in the Chaoshan area of southeast China...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29667023/liraglutide-effects-on-upper-gastrointestinal-investigations-implications-prior-to-bariatric-surgery
#3
Renuca Modi, Peter Rye, Sarah Cawsey, Daniel W Birch, Arya M Sharma
Liraglutide is a glucagon-like peptide type 1 (GLP-1) analogue that is approved for long-term obesity management in North America. While bariatric surgery remains the gold standard for weight loss, an increasing number of patients are on liraglutide in the setting of ongoing workup for bariatric surgery. The presence of gastrointestinal symptoms prior to bariatric surgery may prompt testing for dysmotility, which affects surgical decision making. Here we report six cases where treatment with liraglutide was associated with reversible reduction in gastric and esophageal motility in screening for bariatric surgery...
April 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29666808/oncological-outcomes-of-the-time-trial-in-esophageal-cancer-is-it-the-era-of-minimally-invasive-esophagectomy
#4
EDITORIAL
Lijie Tan, Han Tang
No abstract text is available yet for this article.
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666807/quality-of-life-assessment-in-esophagectomy-patients
#5
REVIEW
Alla Alghamedi, Gordon Buduhan, Lawrence Tan, Sadeesh Kumar Srinathan, Joanne Sulman, Gail Darling, Biniam Kidane
Esophagectomy is the mainstay of curative therapy for esophageal cancer; however, it is associated with significant morbidity and mortality, with subsequent major impact on quality of life. This paper reviews the evaluation of health-related quality of life (HRQOL) in esophageal cancer patients undergoing curative intent therapy, the relationship between postoperative HRQOL and survival as well the potential utility of pre-treatment HRQOL as a prognostic tool. HRQOL assessment is valuable in helping clinicians understand the impact on patients of esophageal cancer and the various treatments thereof...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666806/the-frontline-of-esophageal-cancer-treatment-questions-to-be-asked-and-answered
#6
REVIEW
Cheng-Che Tu, Po-Kuei Hsu
Achieving a good treatment for esophageal cancer is a great challenge. For early stage cancer, endoscopic treatment is considered the first line and a possible curative therapy. Chemotherapy, radiotherapy, and surgery are all used for the treatment of locally advanced esophageal cancer, administered either alone or combined. Some combinations have proven to be feasible, effective, and superior, such as neoadjuvant chemoradiation (CRT) plus surgery in the Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) trial...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666805/surveillance-or-resection-after-chemoradiation-in-esophageal-cancer
#7
REVIEW
Il-Hwan Park, Jae Y Kim
The treatment of locally advanced esophageal cancer continues to evolve. Previously, surgery was considered the foundation of treatment, but chemoradiation (CRT) has taken on a larger role both in the neoadjuvant setting and as definitive treatment. It has become clear that although some patients benefit from esophagectomy after CRT, a large subset of patients likely derive no benefit, and may be harmed by surgery. Some patients are cured from CRT alone and therefore do not need surgery. Another group of patients likely have metastatic disease at the time of local therapy that is just undetected on imaging and also do not benefit from surgery...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666804/surveillance-versus-esophagectomy-in-esophageal-cancer-patients-with-a-clinical-complete-response-after-induction-chemoradiation
#8
REVIEW
Tara R Semenkovich, Bryan F Meyers
There currently exists an area of controversy in treatment of esophageal cancer for patients who have an apparent clinical complete response (cCR) after induction chemoradiation. A standard treatment is to offer these patients an esophagectomy, but increasingly there is interest from both the patient and provider for active surveillance with so-called "salvage" esophagectomies for local recurrence as an alternative treatment paradigm. In this article, we review the existing evidence that stakeholders should consider for clinical decision-making in this specific patient population, including: the accuracy of post-induction clinical restaging, the reliability of operative risk assessment, the feasibility and adherence to surveillance strategies, and the observed outcomes in these patients after salvage esophagectomy or continued active surveillance...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666803/personalized-therapy-based-on-image-for-esophageal-or-gastroesophageal-junction-adenocarcinoma
#9
REVIEW
Kazuto Harada, Dilsa Mizrak Kaya, Anthony Lopez, Hideo Baba, Jaffer A Ajani
Preoperative therapy is the gold standard for esophageal or gastroesophageal junction adenocarcinoma. Positron emission tomography (PET) is not only essential for tumor staging, but changes in glucose consumption correspond with response to therapy and correlated with prognosis. Therefore, with further refinement, PET parameter can serve as a tool for personalized therapy. For instance, the Municon trials suggested the possibility of PET-response guided therapy for esophageal adenocarcinoma (EAC) patients, however there are limitations...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#10
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666800/strategies-of-nodal-staging-of-the-tnm-system-for-esophageal-cancer
#11
REVIEW
Wen-Ping Wang, Song-Lin He, Yu-Shang Yang, Long-Qi Chen
The 8th edition of UICC/AJCC TNM staging for esophageal cancer will start in use since 2018. The nodal staging in this version of TNM system remains unchanged from the 7th edition that based on the number of lymph nodes (LN) involved, except the limited revision of the regional LN map. In this review, N staging revision was evaluated from its initially simple definition of negative (N0) and positive (N1) LN(s) to the current positive node number based proposal. Meanwhile the disadvantages of current N staging were discussed...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666799/comparison-of-two-major-staging-systems-of-esophageal-cancer-toward-more-practical-common-scale-for-tumor-staging
#12
REVIEW
Harushi Udagawa, Masaki Ueno
The latest 8th edition of TNM Classification of Malignant Tumours by Union for International Cancer Control (UICC) and 11th edition of Japanese Classification of Esophageal Cancer by Japan Esophageal Society (JES) are the two major classifications widely accepted as tools for clinical staging of esophageal cancer. Both systems consist of three main categories, i.e., T, N, and M, but large difference exists between the two. JES system has more detailed sub-classification of T1 tumors reflecting meticulous work by Japanese investigators on superficial esophageal cancer...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666798/the-era-of-personalized-multimodal-treatments-for-esophageal-cancer
#13
Po-Kuei Hsu
No abstract text is available yet for this article.
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666743/an-extremely-rare-bile-leakage-aberrant-bile-duct-in-left-triangular-ligament-appendix-fibrosa-hepatis
#14
İhsan Yıldız, Yavuz Savaş Koca, Sezayi Kantar
Background: The anatomical variability of bile ducts can leave surgeons in very difficult conditions.Ultrasonography, computed tomography, magnetic resonance imaging (MRCP) and endoscopic imaging methods are used in diagnosis. In addition to conservative approaches, endoscopic procedures and laparoscopic or open surgical interventions may be necessary for treatment. In this article, we present a case of aberrant bile duct in left triangular ligament (appendix fibrosa hepatis), which is rarely seen...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29666293/fast-or-slow-rescue-ventilations-a-predictive-model-of-gastric-inflation
#15
John R Fitz-Clarke
BACKGROUND: Rescue ventilations are given during respiratory and cardiac arrest. Tidal volume must assure oxygen delivery; however, excessive pressure applied to an unprotected airway can cause gastric inflation, regurgitation, and pulmonary aspiration. The optimal technique provides mouth pressure and breath duration that minimize gastric inflation. It remains unclear if breath delivery should be fast or slow, and how inflation time affects the division of gas flow between the lungs and esophagus...
April 17, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29665050/silence-of-hdac6-suppressed-esophageal-squamous-cell-carcinoma-proliferation-and-migration-by-disrupting-chaperone-function-of-hsp90
#16
Hua Tao, Yuan-Yuan Chen, Zong-Wen Sun, Hua-Lin Chen, Ming Chen
Esophageal carcinoma is aggressive in nature and its prognosis is largely dependent on the degree of invasion. Histone deacetylase 6 (HDAC6), as the most unique member of HDACs family, has the positive activity to promote initiation and progression of various cancers via targeting multiple non-histone proteins in cytoplasm. In this study, we found that HDAC6 was over-expressed in three esophageal cancer cell lines (KYSE140, KYSE170, KYSE180) when compared to non-carcinoma esophageal epithelial cell HEEC-1. Then two HDAC6 specific siRNAs and HDAC6 inhibitor tubastatin A greatly suppressed KYSE140 and KYSE180 cells proliferation and migration, and the inhibition of cell motility was accompanied by elevated acetylation of α-tubulin, a target of HDAC6...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29664654/annual-trends-of-gastrointestinal-cancers-mortality-in-iran-during-1990-2015-nasbod-study
#17
Hamideh Salimzadeh, Farnaz Delavari, Catherine Sauvaget, Negar Rezaee, Alireza Delavari, Farzad Kompani, Nazila Rezaei, Ali Sheidaei, Mitra Modirian, Rosa Haghshenas, Maryam Chegini, Kimiya Gohari, Hossein Zokaiee, Farshad Farzadfar, Reza Malekzadeh
BACKGROUND: Gastrointestinal (GI) neoplasms are among the most common cancers in Iran. This study aimed to measure annual trends in mortality rates from GI cancers in Iran between 1990 and 2015. METHODS: This study was part of an ongoing study termed the 'National and Subnational Burden of Diseases' study in Iran. Data used in this study was obtained from the Iranian Death Registration System (1995 to 2010) and from 2 major cemeteries in Tehran (1995 to 2010) and Isfahan (2007 to 2010)...
February 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29664429/esophageal-ulcers-secondary-to-cryoenergy-after-pulmonary-vein-ablation-using-the-second-generation-balloon
#18
Luis Álvarez-Acosta, Alejandro Quijada-Fumero, Raquel Pimienta-González, Julio S Hernández-Afonso
Pulmonary vein isolation is an effective treatment for patients with symptomatic paroxysmal atrial fibrillation. Cryoablation balloon therapy has been developed as an alternative. Cryoablation complications have primarily been related to phrenic nerve palsy, vascular complications, stroke, and others of lesser incidence. Esophageal lesions are rare and they are not yet completely understood.
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29664357/surgery-for-advanced-lung-and-esophageal-cancer-new-horizons-or-false-dawn
#19
Marcello Migliore, Semih Halezeroglu, Antoon Lerut
No abstract text is available yet for this article.
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29663379/phase-ib-ii-study-of-safety-and-efficacy-of-low-dose-decitabine-primed-chemo-immunotherapy-in-patients-with-drug-resistant-relapsed-refractory-alimentary-tract-cancer
#20
Meixia Chen, Jing Nie, Yang Liu, Xiang Li, Yan Zhang, Malcolm V Brock, Kaichao Feng, Zhiqiang Wu, Xiaolei Li, Lu Shi, Suxia Li, Mingzhou Guo, Qian Mei, Weidong Han
The pressing need for improved therapeutic outcomes provides a good rationale for identifying effective strategies for alimentary tract (AT) cancer treatment. The potential re-sensitivity property to chemo- and immunotherapy of low-dose decitabine has been evident both preclinically and in previous phase I trials. We conducted a phase Ib/II trial evaluating low-dose decitabine primed chemo-immunotherapy in patients with drug-resistant relapsed/refractory esophageal, gastric or colorectal cancers. Forty-five patients received either the 5-day decitabine treatment with subsequent re-administration of the previously resistant chemotherapy (decitabine primed chemotherapy, D-C cohort) or the aforementioned regimen followed by cytokine-induced killer cells therapy (decitabine primed chemotherapy and CIK treatment, D-C+CIK cohort) based on their treatment history...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
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