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https://www.readbyqxmd.com/read/27925255/the-course-of-achalasia-one-to-four-decades-after-initial-treatment
#1
T Sawas, K Ravi, D M Geno, F Enders, K Pierce, D Wigle, D A Katzka
BACKGROUND: Most follow-up studies of achalasia are limited to <5 years. AIMS: To study the long-term efficacy of pneumatic dilation (PD) and myotomy in achalasia at least 10 years after treatment. METHODS: We performed a retrospective cohort study of achalasia patients with >10 years follow-up after initial myotomy or pneumatic dilation. Symptom recurrence which required repeat dilation or surgery was compared between pneumatic dilation and myotomy...
December 7, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27924506/gasless-laparoscopic-surgery-plus-abdominal-wall-lifting-for-giant-hiatal-hernia-our-single-center-experience
#2
Jiang-Hong Yu, Ji-Xiang Wu, Lei Yu, Jian-Ye Li
Giant hiatal hernia (GHH) comprises 5% of hiatal hernia and is associated with significant complications. The traditional operative procedure, no matter transthoracic or transabdomen repair of giant hiatal hernia, is characteristic of more invasion and more complications. Although laparoscopic repair as a minimally invasive surgery is accepted, a part of patients can not tolerate pneumoperitoneum because of combination with cardiopulmonary diseases or severe posterior mediastinal and neck emphesema during operation...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27921050/esophagus-related-symptoms-in-first-degree-relatives-of-patients-with-achalasia-is-screening-necessary
#3
Henning R Gockel, Moritz Lesse, Johannes Schumacher, Michaela Müller, Ines Gockel
BACKGROUND: Despite an increasing understanding of the pathophysiology of achalasia, the etiology of this esophageal motility disorder remains largely unknown. However, the occurrence of familial achalasia, its association with well-defined genetic syndromes, the candidate gene approach, and recent presentation of the first systematic genome-wide association study on achalasia suggest the involvement of genetic factors. METHODS: In this study we analyzed the frequency with which symptoms associated with esophageal function (swallowing difficulties, regurgitations, retrosternal cramps/pain, heartburn) occur in first-degree relatives of patients with achalasia to determine if screening is useful and justified against the background of early diagnosis in a genetically predisposed population...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27913915/age-related-differences-in-clinical-characteristics-and-esophageal-motility-in-patients-with-dysphagia
#4
Rui Nakato, Noriaki Manabe, Tomoari Kamada, Hideo Matsumoto, Akiko Shiotani, Jiro Hata, Ken Haruma
Dysphagia in elderly patients has a major effect on nutrition and quality of life (QOL). Although several studies have shown that aging itself is associated with changes in esophageal motility, the impact of these changes on dysphagia symptoms and QOL is unknown. This study assessed the manometric diagnoses of elderly patients with dysphagia compared with diagnoses in younger counterparts. Participants included 116 consecutive patients examined for dysphagia from 2007 to 2014. We divided patients into three groups by age: Group A, 66 years and older (24 men, 23 women); Group B, 45-65 years (18 men, 24 women); and Group C, 44 years and younger (15 men, 12 women)...
December 2, 2016: Dysphagia
https://www.readbyqxmd.com/read/27889485/safety-and-effectiveness-of-anterior-fundoplication-sleeve-gastrectomy-in-patients-with-severe-reflux
#5
Rena C Moon, Andre F Teixeira, Muhammad A Jawad
BACKGROUND: Laparoscopic sleeve gastrectomy has become a popular bariatric surgery in recent years. However, it has been linked to worsening or newly developed gastroesophageal reflux disease (GERD) in the postoperative period. OBJECTIVES: The purpose of this study is to determine the safety and effectiveness of anterior fundoplication sleeve gastrectomy in patients with reflux. SETTING: Academic hospital, United States. METHODS: We prospectively collected data on 31 sleeve gastrectomy patients who concurrently underwent anterior fundoplication between July 2014 and March 2016...
October 17, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27875359/symptom-index-or-symptom-association-probability-a-closer-look-at-symptom-association-in-suspected-gerd-patients
#6
Mustafa Abdul-Hussein, Crystal Zhang, Donald Castell
BACKGROUND: Symptom index (SI) and symptom association probability (SAP) are popular methods used to measure symptom association in patients with gastroesophageal reflux disease (GERD). AIM: To investigate whether these 2 methods yield similar results in analysis of both typical and atypical GERD symptoms. MATERIALS AND METHODS: Combined impedance-pH reflux studies of 1471 patients tested for possible GERD symptoms from January 2010 to May 2015 were reviewed...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875096/paraesophageal-hernia-repair-techniques-for-success
#7
Tyler D Cohn, Nathaniel J Soper
With the introduction of laparoscopy, the outcomes of patients undergoing paraesophageal hernia repair have improved dramatically. When the fundamentals of a proper repair are followed, patients can expect to have improvement in gastroesophageal reflux symptoms, including heartburn, regurgitation, chest pain, dysphagia, and dyspnea. Adhering to these principles will alleviate patients' symptoms and avoid reoperation. This article describes the approach to paraesophageal hernia repair, including patient evaluation, operative technique, and postoperative management...
November 22, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27868281/long-term-benefit-of-transoral-incisionless-fundoplication-using-the-esophyx-device-for-the-management-of-gastroesophageal-reflux-disease-responsive-to-medical-therapy
#8
Gerasimos Stefanidis, Nikos Viazis, Nikolaos Kotsikoros, Nikolaos Tsoukalas, Eythymia Lala, Loukas Theocharis, Andreas Fassaris, Spilios Manolakopoulos
Transoral incisionless fundoplication (TIF) using the EsophyX device has been shown to be effective and safe in patients with Gastroesophageal reflux disease (GERD); however, the subset of patients that would mostly benefit from this technique remains unknown. The aim of this study was to evaluate the long-term efficacy and safety of the TIF procedure in patients with a history of esophagitis or proven chronic GERD who have achieved symptom control with the administration of proton pump inhibitors (PPIs) but did not wish to continue receiving medications for life...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27863777/concentration-of-serum-calcium-is-not-correlated-with-symptoms-or-severity-of-primary-hyperparathyroidism-an-examination-of-20-081-consecutive-adults
#9
Deva Boone, Douglas Politz, Jose Lopez, Jamie Mitchell, Kevin Parrack, James Norman
BACKGROUND: Guidelines for operative treatment of primary hyperparathyroidism include calcium levels >1 mg/dL above normal. We sought to determine whether greater calcium concentrations were associated with increased symptoms or disease severity. METHODS: A retrospective review of a prospectively maintained database of adults undergoing parathyroidectomy for primary hyperparathyroidism, grouped according to greatest preoperative calcium level: those patients with calcium concentrations between 10...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27862680/the-natural-history-of-gastro-esophageal-reflux-disease-a-comprehensive-review
#10
REVIEW
E Savarino, N de Bortoli, C De Cassan, M Della Coletta, O Bartolo, M Furnari, A Ottonello, E Marabotto, G Bodini, V Savarino
Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27861354/psychological-distress-as-a-crucial-determinant-for-quality-of-life-in-patients-with-noncardiac-chest-pain-in-central-china-a-cross-sectional-study
#11
Lei Zhang, Lei Tu, Jie Chen, Tao Bai, Jun Song, Xuelian Xiang, Ruiyun Wang, Xiaohua Hou
Increased psychiatric comorbidity, predominantly anxiety and depressive symptoms, and lower quality of life (QoL) are associated with noncardiac chest pain (NCCP). We aimed to investigate the roles of anxiety and depression in the impaired QoL of NCCP patients in Central China.In this hospital-based cross-sectional study, 200 consecutive patients who complained of chest pain with normal coronary angiography were enrolled in the Department of Cardiology and Gastroenterology, Union Hospital, Wuhan, China. Meanwhile, 100 healthy controls, with age and sex-matched, were recruited...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858520/fundoplication-for-gastroesophageal-reflux-disease-tips-for-success
#12
Marco G Patti, Francisco Schlottmann, Timothy M Farrell
Gastroesophageal reflux disease affects almost 20% of the population in the United States. Today, proton pump inhibitors are the most frequently prescribed drugs, with an estimated cost of 10 billion dollars per year. Although these medications control heartburn in the majority of patients, other symptoms such as regurgitation and respiratory symptoms often are not controlled, particularly in patients with large hiatal hernias. In these patients a properly performed laparoscopic fundoplication controls esophageal and extraesophageal symptoms and avoids life-long medical therapy...
November 18, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27855990/-parathyroid-disease-the-full-spectrum-from-adenoma-to-carcinoma-report-of-3-cases
#13
Enrique Stoopen-Margain, Sofía Valanci-Aroesty, Leopoldo Castañeda-Martínez, Javier Baquera-Heredia, Juan Carlos Sainz-Hernández
BACKGROUND: Primary hyperparathyroidism is a disease characterised by the autonomous production of parathyroid hormone. The most common cause is an adenoma, followed by hyperplasia, and rarely carcinoma. CLINICAL CASES: Three cases are presented. The first case is associated with a brown tumour that was diagnosed as hyperplasia after study and surgery. The second case was related to pathological fractures, and a lower right adenoma 236 times bigger than a normal parathyroid was excised...
November 14, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27826993/psychometric-evaluation-of-a-daily-gastro-oesophageal-reflux-disease-symptom-measure
#14
Peter Bytzer, Christina Reimer, Gary Smith, Milena D Anatchkova, Ray Hsieh, Joanne Wilkinson, S Jane Thomas, William R Lenderking
OBJECTIVE: The objective of this study was to evaluate the validity of the Heartburn Reflux Dyspepsia Questionnaire (HRDQ), a newly developed measure of gastro-oesophageal reflux disease (GORD) symptoms. Specifically, the HRDQ was developed for patients, who still experience symptoms with proton pump inhibitor (PPI) treatment. MATERIAL AND METHODS: The psychometric properties of HRDQ were evaluated based on data from two clinical trials of patients with GORD with a partial response to PPIs, one from the UK and one from Denmark and Germany...
November 9, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27818697/efficacy-and-safety-of-a-natural-remedy-for-the-treatment-of-gastroesophageal-reflux-a-double-blinded-randomized-controlled-study
#15
Umberto Alecci, Francesco Bonina, Andrea Bonina, Luisa Rizza, Santi Inferrera, Carmen Mannucci, Gioacchino Calapai
Gastroesophageal reflux (GER) is a common, chronic, relapsing symptom. Often people self-diagnose and self-treat it even though health-related quality of life is significantly impaired. In the lack of a valid alternative approach, current treatments focus on suppression of gastric acid secretion by the use of proton pump inhibitors (PPIs), but people with GER have a significantly lower response rate to therapy. We designed a randomized double-blinded controlled clinical study to evaluate the efficacy and the safety of a formulation based on sodium alginate/bicarbonate in combination with extracts obtained from Opuntia ficus-indica and Olea europaea associated with polyphenols (Mucosave®; verum), on GER-related symptoms...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27797289/snus-and-risk-of-gastroesophageal-reflux-a-population-based-case-control-study-the-hunt-study
#16
Tina Malene Lie, Maria Bomme, Kristian Hveem, Jane Møller Hansen, Eivind Ness-Jensen
OBJECTIVE: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of gastroesophageal reflux symptoms (GERS). MATERIAL AND METHODS: The study was based on the third Nord-Trøndelag health study (HUNT3), a population-based study of all adult residents in Nord-Trøndelag County, Norway, performed in 2006-2009. The association between self-reported severe heartburn/regurgitation and snus use was assessed by logistic regression...
October 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27796767/endoluminal-therapy-for-gastroesophageal-reflux-disease-in-between-the-pill-and-the-knife
#17
REVIEW
Tony S Brar, Peter V Draganov, Dennis Yang
Gastroesophageal reflux disease (GERD) is a chronic disease characterized by symptoms of heartburn and acid regurgitation. Uncontrolled GERD can significantly impact quality of life, can lead to complications, and increases the risk of esophageal cancer. Over the past few decades, there has been an increasing prevalence of GERD among adults in Western populations. The use of proton pump inhibitors (PPI) in conjunction with lifestyle modifications remains the mainstay therapy. However, the efficacy of this intervention is often hampered by adherence, costs, and the risks of long-term PPI use...
October 28, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27785326/a-rare-disease-of-the-digestive-tract-esophageal-melanosis
#18
Sebahattin Destek, Vahit Onur Gul, Serkan Ahioglu, Yesim Erbil
Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this report, we aimed to note esophageal melanosis in a 55-year-old female case who applied to our clinic with difficulty in swallowing, burning behind the breastbone in the stomach, heartburn, indigestion, and pain in the upper abdomen after endoscopic and pathologic evaluation...
June 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27784974/incidence-clinical-features-and-para-clinical-findings-of-achalasia-in-algeria-experience-of-25-years
#19
Amar Tebaibia, Mohammed Amine Boudjella, Djamel Boutarene, Farouk Benmediouni, Hakim Brahimi, Nadia Oumnia
AIM: To investigate the incidence of achalasia in Algeria and to determine its clinical and para-clinical profile. To evaluate the impact of continuing medical education (CME) on the incidence of this disease. METHODS: From 1990 to 2014, 1256 patients with achalasia were enrolled in this prospective study. A campaign of CME on diagnosis involving different regions of the country was conducted between 1999 and 2003. Annual incidence and prevalence were calculated by relating the number of diagnosed cases to 10(5) inhabitants...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27780751/medicinal-plants-used-in-lesotho-for-treatment-of-reproductive-and-post-reproductive-problems
#20
A Moteetee, L Seleteng Kose
ETHNOPHARMACOLOGICAL RELEVANCE: Reproductive healthcare has been highlighted as a major challenge in Lesotho mainly due to the high prevalence of HIV/AIDS and sexually transmitted infections. As a result other reproductive ailments have not received much attention, particularly because healthcare facilities are already limited and many of them are inaccessible. For these reasons, medicinal plants play a major role in primary healthcare system in the country, in addition the plants are easily accessible, more affordable, and their use forms part of the cultural heritage...
October 22, 2016: Journal of Ethnopharmacology
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