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https://www.readbyqxmd.com/read/29662932/combined-extensive-esophageal-squamous-papillomas-and-florid-cardiac-gland-hyperplasia-in-a-patient-with-adenocarcinoma
#1
Takanori Suganuma, Han-Seung Yoon
We report a rare case of extensive esophageal squamous papillomas (ESPs) involving the entire esophagus and florid cardiac gland hyperplasia involving only the lower esophagus in a 39-year-old woman with heartburn and epigastric distress for the past 2 years. Previous esophagogastroduodenoscopy showed multiple ESPs involving the entire esophagus extending 38 cm from the esophageal orifice to the esophagogastric junction (EGJ). Additionally, prominent cardiac gland hyperplasia over the esophageal posterior wall was exhibited extending 12 cm from the mid-esophagus to the EGJ...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29662293/maintenance-for-healed-erosive-esophagitis-phase-iii-comparison-of-vonoprazan-with-lansoprazole
#2
Kiyoshi Ashida, Katsuhiko Iwakiri, Naoki Hiramatsu, Yuuichi Sakurai, Tetsuharu Hori, Kentarou Kudou, Akira Nishimura, Eiji Umegaki
AIM: To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis (EE). METHODS: A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg ( n = 201), vonoprazan 10 mg ( n = 202), or vonoprazan 20 mg ( n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29619511/results-of-magnetic-sphincter-augmentation-for-gastroesophageal-reflux-disease
#3
Katrin Schwameis, Milena Nikolic, Deivis G Morales Castellano, Ariane Steindl, Sarah Macheck, Ivan Kristo, Barbara Zörner, Sebastian F Schoppmann
BACKGROUND: Magnetic sphincter augmentation (MSA) is a modern treatment option for gastroesophageal reflux disease (GERD); however, laparoscopic fundoplication remains the gold standard. The aim of the study was to evaluate outcomes of MSA patients at a reflux center. METHODS: A retrospective review was performed of all patients that underwent MSA between March 2012 and November 2017. Out of 110 patients, 68 with a follow-up >3 months were included. Postoperative gastrointestinal symptoms, proton pump inhibitor (PPI) intake, GERD-Health-related Quality of Life (GERD-HRQL) and alimentary satisfaction (AS) were assessed...
April 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29616831/identifying-clinically-relevant-sliding-hiatal-hernias-a-population-based-endoscopy-study
#4
Bengt Wallner, Ove Björ, Anna Andreasson, Per M Hellström, Anna M Forsberg, Nicholas J Talley, Lars Agreus
OBJECTIVES: The clinical relevance of small to moderate sliding hiatal hernias is controversial. The aims of the present study were to (1) investigate which symptoms are associated with sliding hiatal hernias and (2) define the length of a sliding hiatal hernia at which gastrointestinal symptoms occur. METHODS: A study population representative of the general Swedish population answered a questionnaire regarding gastrointestinal symptoms and was investigated with an upper endoscopy...
April 4, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29608193/compounded-oral-viscous-budesonide-is-effective-and-provides-a-durable-response-in-eosinophilic-esophagitis
#5
Craig C Reed, Claire Fan, Nathaniel Koutlas, Zoe Stefanadis, Swathi Eluri, Nicholas J Shaheen, Evan S Dellon
Aim: Because no approved medications exist for eosinophilic esophagitis (EoE), patients must use off-label drugs or create their own formulations. We assessed the efficacy of a standardized compounded budesonide suspension for treatment of EoE. Materials and methods: We conducted a retrospective cohort study of EoE patients at the University of North Carolina treated with compounded budesonide dispensed by a specialty compounding pharmacy. Outcomes (symptomatic global response [yes/no], endoscopic response [% with individual findings], and histologic response [absolute eosinophil count; % with <15 eos/hpf])were assessed after the initial and last treatment in our system...
2018: HSOA journal of gastroenterology & hepatology research
https://www.readbyqxmd.com/read/29607496/enteral-nutritional-therapy-for-induction-of-remission-in-crohn-s-disease
#6
REVIEW
Neeraj Narula, Amit Dhillon, Dongni Zhang, Mary E Sherlock, Melody Tondeur, Mary Zachos
BACKGROUND: Corticosteroids are often preferred over enteral nutrition (EN) as induction therapy for Crohn's disease (CD). Prior meta-analyses suggest that corticosteroids are superior to EN for induction of remission in CD. Treatment failures in EN trials are often due to poor compliance, with dropouts frequently due to poor acceptance of a nasogastric tube and unpalatable formulations. This systematic review is an update of a previously published Cochrane review. OBJECTIVES: To evaluate the effectiveness and safety of exclusive EN as primary therapy to induce remission in CD and to examine the importance of formula composition on effectiveness...
April 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29605985/lower-and-upper-gastrointestinal-symptoms-differ-between-individuals-with-irritable-bowel-syndrome-with-constipation-or-chronic-idiopathic-constipation
#7
Eric D Shah, Christopher V Almario, Brennan M R Spiegel, William D Chey
Background/Aims: We evaluated the distribution of lower and upper gastrointestinal (GI) symptoms among individuals with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in a nationwide survey. Methods: Individuals (≥ 18 years of age) were identified from a nationwide sample of > 70 000 United States adults. Participants completed the National Institutes of Health GI Patient Reported Outcomes Measurement Information System (NIH GI-PROMIS) questionnaire...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29605980/diagnostic-trends-and-clinical-characteristics-of-eosinophilic-esophagitis-a-korean-single-center-database-study
#8
Ga Hee Kim, Kee Wook Jung, Hwoon-Yong Jung, Kee Don Choi, JungBok Lee, Young Soo Park, So-Woon Kim, Jeong Hoon Lee, Do Hoon Kim, Ji Yong Ahn, Ho June Song, Gin Hyug Lee, Jin-Ho Kim
Background/Aims: The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods: Using an endoscopic database maintained at a tertiary care center, we retrospectively reviewed the biopsy reports regarding 18 399 biopsy specimens collected from all patients who underwent esophagogastroduodenoscopy and esophageal biopsy at this facility between 2006 and 2014...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29599677/venom-immunotherapy-and-pregnancy
#9
Krzysztof Pałgan, Magdalena Żbikowska-Götz, Elżbieta Chrzaniecka, Zbigniew Bartuzi
Introductions: The efficiency of venom immunotherapy (VIT) has been well documented by many studies. However, the most important for VIT is safety, particularly for a pregnant woman and a fetus. Aim: To establish the influence of continuation of VIT on pregnant women and offspring. Material and methods: The 6 women became pregnant during a specific immunotherapy. We retrospectively analyzed the influence of the immunotherapy on any complications for the pregnant women and their infants...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29597000/cough-reflex-sensitivity-does-not-correlate-with-the-esophageal-sensitivity-to-acid-in-patients-with-gastroesophageal-reflux-disease
#10
Martin Duricek, Lenka Nosakova, Tomas Zatko, Renata Pecova, Rudolf Hyrdel, Peter Banovcin
The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the relationship between cough reflex sensitivity (CRS) and esophageal sensitivity to acid. We evaluated CRS to capsaicin inhalation and esophageal sensitivity to acid (intensity of heartburn evoked by esophageal infusions of acid pH = 3, 2 and 1) in patients with GERD and chronic heartburn before and 3 months after proton pump inhibitor (PPI) treatment...
March 26, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29587423/iodine-and-pregnancy-a-qualitative-study-focusing-on-dietary-guidance-and-information
#11
Maria Bouga, Michael E J Lean, Emilie Combet
Iodine is essential for thyroid hormones synthesis and normal neurodevelopment; however, ~60% of pregnant women do not meet the WHO (World Health Organization) recommended intake. Using a qualitative design, we explored the perceptions, awareness, and experiences of pregnancy nutrition, focusing on iodine. Women in the perinatal period ( n = 48) were interviewed and filled in a food frequency questionnaire for iodine. Almost all participants achieved the recommended 150 μg/day intake for non-pregnant adults (99%), but only 81% met the increased demands of pregnancy (250 μg/day)...
March 26, 2018: Nutrients
https://www.readbyqxmd.com/read/29580341/laparoscopic-heller-myotomy-with-anterior-fundoplication-improves-frequency-and-severity-of-symptoms-of-achalasia-regardless-of-preoperative-severity-determined-by-esophagography
#12
Alexander Rosemurgy, Darrell Downs, Kenneth Luberice, Christian Rodriguez, Forat Swaid, Krishen Patel, Paul Toomey, Sharona Ross
This study was undertaken to determine whether postoperative outcomes after laparoscopic Heller myotomy with anterior fundoplication could be predicted by preoperative findings on esophagography. Preoperative barium esophagograms of 135 patients undergoing laparoscopic Heller myotomy with anterior fundoplication were reviewed. The number of esophageal curves, esophageal width, and angulation of the gastroesophageal junction (GEJ) were determined; correlations between these determined parameters and symptoms were assessed using linear regression analysis...
February 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29560670/current-status-of-gastroesophageal-reflux-disease-diagnosis-and-treatment
#13
REVIEW
Tang-Wei Chuang, Shou-Chien Chen, Kow-Tong Chen
AIMS: The aim of this study was to explore the recent advances in diagnosis and treatment of gastroesophageal reflux disease (GERD). METHODS: Previous studies were searched using the terms "gastroesophageal reflux disease" and "diagnosis" or "treatment" in Medline and Pubmed. Articles that were not published in the English language, manuscripts without an abstract, reviews, meta-analysis, and opinion articles were excluded from the review...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29560641/the-association-between-gastroesophageal-flap-valve-function-and-gastroesophageal-reflux-symptoms
#14
O Keskin, Ç Kalkan, A Yaman, A Tüzün, I Soykan
BACKGROUND AND STUDY AIMS: Upper gastrointestinal endoscopic examination is usually the first step in the evaluation of patients with suspected gastroesopageal reflux disease. The primary aim of this study was to investigate the association between gastroesophageal flap valve function (GEFV) and gastroesophapgeal reflux symptoms in patients undergoing routine upper endoscopy. Patients and methods: 1507 patients were included into the study and the GEFV graded I to IV as follows: Hill I-II: normal GEFV, and Hill III-IV: abnormal GEFV...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29559793/clinicopathological-features-and-prognosis-in-elderly-gastric-cancer-patients-a-retrospective-cohort-study
#15
Guanghui Xu, Fan Feng, Shushang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Lei Cai, Man Guo, Xiao Lian, Hongwei Zhang
Background: Little is known about the clinicopathological features and prognosis in elderly gastric cancer (GC) patients aged 65-79 years. The aim of this study was to evaluate clinicopathological features and prognosis in elderly GC patients. Patients and methods: From May 2008 to December 2014, a total of 5,282 GC patients were enrolled in our present study. Patients were divided into elderly and middle-aged groups. The clinicopathological features and clinical outcomes were analyzed...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29542847/impaired-motility-in-barrett-s-esophagus-a-study-using-high-resolution-manometry-with-physiologic-challenge
#16
S Sanagapalli, A Emmanuel, R Leong, S Kerr, L Lovat, R Haidry, M Banks, D Graham, A Raeburn, N Zarate-Lopez, R Sweis
BACKGROUND: Esophageal dysmotility may predispose to Barrett's esophagus (BE). We hypothesized that high-resolution manometry (HRM) performed with additional physiologic challenge would better delineate dysmotility in BE. METHODS: Included patients had typical reflux symptoms and underwent endoscopy, HRM with single water swallows and adjunctive testing with solids and rapid drink challenge (RDC) before ambulatory pH-impedance monitoring. BE and endoscopy-negative reflux disease (ENRD) subjects were compared against functional heartburn patient-controls (FHC)...
March 15, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29540336/a-randomized-double-blind-controlled-multi-center-study-of-ilaparazole-in-the-treatment-of-reflux-esophagitis-phase-iii-clinical-trial
#17
Yan Xue, Xianghong Qin, Liya Zhou, Sanren Lin, Ling Wang, Haitang Hu, Jielai Xia
AIM AND BACKGROUND: Proton pump inhibitors (PPIs) are the main drugs for the treatment of reflux esophagitis. Phase II clinical trials showed that, compared with Esomeprazole, the new PPI Ilaparazole is great in terms of efficacy for reflux symptoms relief and curling for esophagitis. The aim of this study was to confirm suitable dose of Ilaparazole in the treatment of reflux esophagitis. METHODS: This study used a randomized, double-blind, parallel positive drug control, multi-center design...
March 11, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29534167/simultaneous-laryngopharyngeal-ph-monitoring-restech-and-conventional-esophageal-ph-monitoring-correlation-using-a-large-patient-cohort-of-more-than-100-patients-with-suspected-gastroesophageal-reflux-disease
#18
H F Fuchs, D T Müller, F Berlth, M K Maus, C Fuchs, M Dübbers, W Schröder, C J Bruns, J M Leers
24-hour esophageal pH-metry is not designed to detect laryngopharyngeal reflux (LPR). The new laryngopharyngeal pH-monitoring system (Restech) may detect LPR better. There is no established correlation between these two techniques as only small case series exist. The aim of this study is to examine the correlation between the two techniques with a large patient cohort. All patients received a complete diagnostic workup for gastroesophageal reflux including symptom evaluation, endoscopy, 24-hour pH-metry, high resolution manometry, and Restech...
March 8, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29528205/functional-gastrointestinal-disorders-functional-upper-gastrointestinal-disorders-in-adults
#19
Michael Malone, Abdul Waheed, Samiullah Samiullah
Functional upper gastrointestinal disorders are common and cause significant patient distress and health care cost. These disorders typically are classified as either esophageal or gastroduodenal. Functional esophageal disorders include functional heartburn, reflux hypersensitivity, and functional dysphagia. Functional gastroduodenal disorders include functional dyspepsia and cyclic vomiting syndrome. Cyclic vomiting syndrome should be suspected in any patient with multiple episodes of vomiting with no apparent cause that completely resolve between episodes...
March 2018: FP Essentials
https://www.readbyqxmd.com/read/29526236/efficacy-and-safety-of-amla-phyllanthus-emblica-l-in-non-erosive-reflux-disease-a-double-blind-randomized-placebo-controlled-clinical-trial
#20
Shahnaz Karkon Varnosfaderani, Fataneh Hashem-Dabaghian, Gholamreza Amin, Mahbubeh Bozorgi, Ghazaleh Heydarirad, Esmaeil Nazem, Mohsen Nasiri Toosi, Seyed Hamdollah Mosavat
BACKGROUND: Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal complaints. GERD, caused by the reflux of stomach contents into the esophagus, leads to troublesome symptoms such as heartburn and regurgitation. It is classified into two types: erosive esophagitis, characterized by visible esophageal mucosa erosion in endoscopy, and non-erosive reflux disease (NERD). GERD is a chronic and recurrent disease that impairs the quality of life and imposes socioeconomic and therapeutic burdens to both patients and society...
March 2018: Journal of Integrative Medicine
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