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Spinal cord injury rehabilitation

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https://www.readbyqxmd.com/read/28211825/multiple-mediation-path-model-of-pain-s-cascading-influence-on-physical-disability-in%C3%A2-individuals-with-sci-from-colombia-south-america
#1
Paul B Perrin, Alejandra Morlett Paredes, Silvia Leonor Olivera, Juan Esteban Lozano, Wendy Tatiana Leal, Usman F Ahmad, Juan Carlos Arango-Lasprilla
BACKGROUND: Research has begun to document the bivariate connections between pain in individuals with spinal cord injury (SCI) and various aspects of health related quality of life (HRQOL), such as fatigue, social functioning, mental health, and physical functioning. OBJECTIVE: The purpose of this study was to construct and test a theoretical path model illuminating the stage-wise and sequential (cascading) HRQOL pathways through which pain increases physical disability in individuals with SCI in a sample from Colombia, South America...
February 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28210068/use-of-an-arm-weight-bearing-combined-with-upper-limb-reaching-apparatus-to-facilitate-motor-paralysis-recovery-in-an-incomplete-spinal-cord-injury-patient-a-single-case-report
#2
Takashi Hoei, Kazumi Kawahira, Hidefumi Fukuda, Keizo Sihgenobu, Megumi Shimodozono, Tadashi Ogura
[Purpose] Training using an arm weight-bearing device combined with upper-limb reaching apparatus to facilitate motor paralysis recovery, named the "Reaching Robot", as well as Repetitive Facilitation Exercise were applied to a patient with severe impairment of the shoulder and elbow due to incomplete spinal cord injury and the effects were examined. [Subjects and Methods] A 66-year-old man with incomplete spinal cord injury participated in an upper extremity rehabilitation program involving a Reaching Robot...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28208601/surgical-neurostimulation-for-spinal-cord-injury
#3
REVIEW
Aswin Chari, Ian D Hentall, Marios C Papadopoulos, Erlick A C Pereira
Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI...
February 10, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28199003/applications-of-induced-pluripotent-stem-cell-technologies-in-spinal-cord-injury
#4
REVIEW
Narihito Nagoshi, Hideyuki Okano
Numerous basic research studies have suggested the potential efficacy of neural precursor cell (NPC) transplantation in spinal cord injury (SCI). However, in most such studies the origin of the cells used was mainly fetal tissue or embryonic stem cells, both of which carry potential ethical concerns with respect to clinical use. The development of induced pluripotent stem cells (iPSCs) opened a new path toward regenerative medicine for SCI. iPSCs can be generated from somatic cells by induction of transcription factors, and induced to differentiate into NPCs with characteristics of cells of the central nervous system...
February 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28197198/application-of-a-paraplegic-gait-orthosis-in-thoracolumbar-spinal-cord-injury
#5
Lang Shuai, Guo-Hua Yu, Zhen Feng, Wan-Song Wang, Wei-Ming Sun, Lu Zhou, Yin Yan
Paraplegic gait orthosis has been shown to help paraplegic patients stand and walk, although this method cannot be individualized for patients with different spinal cord injuries and functional recovery of the lower extremities. There is, however, a great need to develop individualized paraplegic orthosis to improve overall quality of life for paraplegic patients. In the present study, 36 spinal cord (below T4) injury patients were equally and randomly divided into control and observation groups. The control group received systematic rehabilitation training, including maintenance of joint range of motion, residual muscle strength training, standing training, balance training, and functional electrical stimulation...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28192079/electrical-neuromodulation-of-the-cervical-spinal-cord-facilitates-forelimb-skilled-function-recovery-in-spinal-cord-injured-rats
#6
Monzurul Alam, Guillermo Garcia-Alias, Benita Jin, Jonathan Keyes, Hui Zhong, Roland R Roy, Yury Gerasimenko, Daniel C Lu, V Reggie Edgerton
Enabling motor control by epidural electrical stimulation of the spinal cord is a promising therapeutic technique for the recovery of motor function after a spinal cord injury (SCI). Although epidural electrical stimulation has resulted in improvement in hindlimb motor function, it is unknown whether it has any therapeutic benefit for improving forelimb fine motor function after a cervical SCI. We tested whether trains of pulses delivered at spinal cord segments C6 and C8 would facilitate the recovery of forelimb fine motor control after a cervical SCI in rats...
February 9, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28181797/a-thermosensitive-heparin-poloxamer-hydrogel-bridge-afgf-to-treat-spinal-cord-injury
#7
Qingqing Wang, Yan He, Yingzheng Zhao, Huixu Xie, Qian Lin, Zili He, Xiaoyan Wang, Jiawei Li, Hongyu Zhang, Chenggui Wang, Fanghua Gong, Xiaokun Li, Huazi Xu, Qingsong Ye, Jian Xiao
Acidic fibroblast growth factor (aFGF) exerts a protective effect on spinal cord injury (SCI) but is limited by the lack of physicochemical stability andthe ability to cross the blood spinal cord barrier (BSCB). As promising biomaterials, hydrogels contain substantial amounts of water and a 3D porous structureand are commonly used to load and deliver growth factors. Heparin can not only enhance growth factor loading onto hydrogels but also can stabilize the structure and control the release behavior. Herein, a novel aFGF-loaded thermosensitive heparin-poloxamer (aFGF-HP) hydrogel was developed and applied to provide protection and regeneration after SCI...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28173745/characterization-of-chronic-axonal-degeneration-using-diffusion-tensor-imaging-in-canine-spinal-cord-injury-a-quantitative-analysis-of-dti-parameters-according-to-histopathological-differences
#8
Hakyoung Yoon, Jaehwan Kim, Won-Jin Moon, Sang-Soep Nahm, Jun Zhao, Hyoung-Moon Kim, Kidong Eom
Diffusion tensor imaging (DTI) is more sensitive than conventional magnetic resonance imaging (MRI) for the identification of axonal degeneration. However, no study to date has used DTI to evaluate the severity of axonal degeneration in canine spinal cord injury. Therefore, the aim of this study was to characterize multi-grade axonal degeneration (mild, moderate, and severe) in a canine model of spinal cord compression injury using DTI. MRI data were obtained from six normal dogs and five dogs with lumbar spinal cord injury 78 days after spinal cord injury (L1-L3) using a 3T MRI scanner...
February 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28169294/factors-predictive-of-survival-and-estimated-years-of-life-lost-in-the-decade-following-nontraumatic-and-traumatic-spinal-cord-injury
#9
B B Hatch, C M Wood-Wentz, T M Therneau, M G Walker, J M Payne, R K Reeves
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To identify factors predictive of survival after spinal cord injury (SCI). SETTING: Tertiary care institution. METHODS: Multiple-variable Cox proportional hazards regression analysis for 759 patients with SCI (535 nontraumatic and 221 traumatic) included age, sex, completeness of injury, level of injury, functional independence measure (FIM) scores, rehabilitation length of stay and SCI cause...
February 7, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28166116/cerebral-blood-flow-responses-to-aquatic-treadmill-exercise
#10
Rhodri Parfitt, Marianne Y Hensman, Samuel J E Lucas
INTRODUCTION: Aquatic treadmills are used as a rehabilitation method for conditions such as spinal cord injury, osteoarthritis and stroke, and can facilitate an earlier return to exercise training for athletes. However, their effect on cerebral blood flow (CBF) responses has not been examined. We tested the hypothesis that aquatic treadmill exercise would augment CBF and lower heart rate compared to land-based treadmill exercise. METHODS: Eleven participants completed incremental exercise (crossover design) starting from walking pace [4 km/h, immersed to iliac crest (aquatic), 6 km/h (land)] and increasing 1 km/h every 2 min up to 10 km/h for aquatic (maximum belt speed) or 12 km/h for land...
February 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28139661/spinal-cord-injury-rehabilitation-in-riyadh-saudi-arabia-time-to-rehabilitation-admission-length-of-stay-and-functional-independence
#11
H Mahmoud, H Qannam, D Zbogar, B Mortenson
OBJECTIVES: (1) To describe functional status, length of stay (LOS) and time to rehabilitation admission trends. (2) To identify independent predictors of motor function following rehabilitation. STUDY DESIGN: Retrospective cohort study. SETTING: Spinal injury rehabilitation unit at King Fahad Medical City, Riyadh, Saudi Arabia. METHODS: From chart review of 312 traumatic and 106 nontraumatic adult patients with spinal cord injury (SCI) we extracted information on time from injury to rehabilitation admission, rehabilitation LOS, Functional Independence Measure (FIM) motor score (admission and discharge), American Spinal Injury Association Impairment Scale (AIS) grade and demographics...
January 31, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28139659/burden-of-care-in-primary-caregivers-of-individuals-with-spinal-cord-injury-in-iran-its-association-with-sociodemographic-factors
#12
Z Khazaeipour, F Rezaei-Motlagh, E Ahmadipour, M Azarnia-Ghavam, A Mirzababaei, N Salimi, A Salehi-Nejad
STUDY DESIGN: A descriptive cross-sectional study. OBJECTIVES: The burden of care among primary caregivers of individuals with spinal cord injury (SCI) is affected by different factors. We aimed to evaluate the level of burden among caregivers and the association between the caregiver burden and sociodemographic factors of SCI individuals and their caregivers. SETTING: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran...
January 31, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28130472/long-term-functional-outcome-in-patients-with-acquired-infections-after-acute-spinal-cord-injury
#13
Marcel A Kopp, Ralf Watzlawick, Peter Martus, Vieri Failli, Felix W Finkenstaedt, Yuying Chen, Michael J DeVivo, Ulrich Dirnagl, Jan M Schwab
OBJECTIVE: To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI). METHODS: This was a longitudinal cohort study within the prospective multicenter National Spinal Cord Injury Database (Birmingham, Alabama). We screened datasets of 3,834 patients enrolled in 20 trial centers from 1995 to 2005 followed up until 2016. Eligibility criteria were cervical SCI and American Spinal Cord Injury Association impairment scale A, B, and C...
January 27, 2017: Neurology
https://www.readbyqxmd.com/read/28130082/inflammatory-mediators-associated-with-pressure-ulcer-development-in-individuals-with-pneumonia-following-traumatic-spinal-cord-injury-a-pilot-study
#14
Shilpa Krishnan, Yoram Vodovotz, Patricia E Karg, Gregory Constantine, Gwendolyn A Sowa, Florica J Constantine, David M Brienza
OBJECTIVE: To identify the inflammatory mediators around the time of pneumonia onset associated with concurrent or later onset of pressure ulcers. DESIGN: Retrospective SETTING: Acute hospitalization and inpatient rehabilitation unit of a university medical center. INTERVENTIONS: NA. PARTICIPANTS: Eighty-six individuals with traumatic SCI were included in the initial analyses. Fifteen of the 86 developed pneumonia and had inflammatory mediator data available...
January 24, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28130079/risk-analyses-of-pressure-ulcer-in-tetraplegic-spinal-cord-injured-persons-a-french-long-term-survey
#15
Marc Le Fort, Maude Espagnacq, Brigitte Perrouin-Verbe, Jean-François Ravaud
OBJECTIVE: To identify the long-term clinical, individual, and social risk factors for the development of pressure ulcers (PUs) in traumatic spinal cord-injured persons with tetraplegia (TSCIt). DESIGN: Cohort survey with self-applied questionnaires in 1995 and 2006. SETTING: Thirty-five French-speaking European physical medicine and rehabilitation centers participating in the Tetrafigap surveys. PARTICIPANTS: A total of 1641 tetraplegic adults were surveyed after an initial post-traumatic period of at least 2 years...
January 24, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28129881/body-image-in-patients-with-spinal-cord-injury-during-inpatient-rehabilitation
#16
Tijn van Diemen, Christel van Leeuwen, Ilse van Nes, Jan Geertzen, Marcel Post
OBJECTIVES: (1) To investigate the course of body image in patients with spinal cord injury (SCI) during their first inpatient rehabilitation stay; and (2) to explore the association between demographic and injury-related variables and body image and the association between body image and psychological distress. DESIGN: Longitudinal inception cohort study. SETTING: Rehabilitation center. PARTICIPANTS: Of the 210 people admitted for their first inpatient SCI rehabilitation program (between March 2011 and April 2015), 188 met the inclusion criteria...
January 24, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28125929/trans-synaptic-degeneration-of-motoneurons-distal-to-chronic-cervical-spinal-cord-compression-in-cervical-spondylotic-myelopathy
#17
Chaojun Zheng, Yu Zhu, Feizhou Lu, Xiaosheng Ma, Dong Tian, Jianyuan Jiang
OBJECTIVE: To assess the effect of chronic cervical spinal cord compression upon remote motor unit function in patients with cervical spondylotic myelopathy (CSM). METHODS: Fifty-three CSM patients and 47 healthy subjects were included. Bilateral motor unit number estimations (MUNEs) were recorded from both abductor digiti minimi and abductor pollicis brevis, and bilateral flexor carpi radialis (FCR) H-reflexes were examined in all subjects along with the nine-hole peg test (NHPT)...
January 26, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28120075/the-rehabilitation-of-spinal-cord-injury-patients-in-europe
#18
Giorgio Scivoletto, Massimo Miscusi, Stefano Forcato, Luca Ricciardi, Mariano Serrao, Roberto Bellitti, Antonino Raco
In Western European countries there is an incidence of traumatic spinal cord injury (SCI) of 16 to 19.4 new cases per million inhabitants per year. Since World War II, European physicians have been fundamental in the development of SCI medicine, starting from Sir Ludwig Guttman, who developed the idea of the integrated treatment of these patients. More recently, scientists from Germany and Switzerland have developed a new rehabilitative approach, Body Weight Support Treadmill Training, based on the concept of activity-based therapy and aimed at restoring walking in SCI patients...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28119846/effects-of-radiation-therapy-on-established-neurogenic-heterotopic-ossification
#19
Chan Ho Lee, Su Jung Shim, Hyun Jung Kim, Hyuna Yang, Youn Joo Kang
Heterotopic ossification (HO) is frequently seen on rehabilitation units after spinal cord injuries, fractures, brain injuries, and limb amputations. Currently, there is no effective treatment for HO other than prophylaxis with anti-inflammatory medications, irradiation, and bisphosphonate administration. These prophylactic treatments are not effective for managing ectopic bone once it has formed. Here we describe three cases of established neurogenic HO treated with radiation therapy (RT). All patients had decreased serum alkaline phosphatase (ALP) and bone-specific ALP levels with decreased pain but increased range of motion immediately after RT...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28119833/large-dose-glucocorticoid-induced-secondary-adrenal-insufficiency-in-spinal-cord-injury
#20
Soo Ho Park, Kang Hee Cho
OBJECTIVE: To investigate the incidence of adrenal insufficiency (AI) in patients with spinal cord injury (SCI) with symptoms similar to those of AI and to assess the relevance of AI and large-dose glucocorticoids in SCI. METHODS: The medical records of 228 patients who were admitted to the rehabilitation center after SCI from January 2014 to January 2016 were reviewed retrospectively. Twenty-nine of 228 patients had persistent symptoms suspicious for AI despite continuous care for more than 4 weeks...
December 2016: Annals of Rehabilitation Medicine
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