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https://www.readbyqxmd.com/read/27916938/comprehensive-analysis-of-mirnome-alterations-in-response-to-sorafenib-treatment-in-colorectal-cancer-cells
#1
Anna-Maria Pehserl, Anna Lena Ress, Stefanie Stanzer, Margit Resel, Michael Karbiener, Elke Stadelmeyer, Verena Stiegelbauer, Armin Gerger, Christian Mayr, Marcel Scheideler, Georg C Hutterer, Thomas Bauernhofer, Tobias Kiesslich, Martin Pichler
MicroRNAs (miRNAs) are master regulators of drug resistance and have been previously proposed as potential biomarkers for the prediction of therapeutic response in colorectal cancer (CRC). Sorafenib, a multi-kinase inhibitor which has been approved for the treatment of liver, renal and thyroid cancer, is currently being studied as a monotherapy in selected molecular subtypes or in combination with other drugs in metastatic CRC. In this study, we explored sorafenib-induced cellular effects in Kirsten rat sarcoma viral oncogene homolog olog (KRAS) wild-type and KRAS-mutated CRC cell lines (Caco-2 and HRT-18), and finally profiled expression changes of specific miRNAs within the miRNome (>1000 human miRNAs) after exposure to sorafenib...
December 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27915448/bone-mineral-content-and-areal-density-but-not-bone-area-predict-an-incident-fracture-risk-a-comparative-study-in-a-uk-prospective-cohort
#2
E M Curtis, N C Harvey, S D'Angelo, C S Cooper, K A Ward, P Taylor, G Pearson, C Cooper
: We studied a prospective UK cohort of women aged 20 to 80 years, assessed by dual-energy X-ray absorptiometry (DXA) at baseline. Bone mineral content (BMC) and areal bone mineral density (aBMD), but not bone area (BA), at femoral neck, lumbar spine and the whole body sites were similarly predictive of incident fractures. BACKGROUND: Low aBMD, measured by DXA, is a well-established risk factor for future fracture, but little is known about the performance characteristics of other DXA measures such as BA and BMC in fracture prediction...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27913171/effects-of-hydraulic-retention-time-hrt-on-denitrification-using-waste-activated-sludge-thermal-hydrolysis-liquid-and-acidogenic-liquid-as-carbon-sources
#3
Yiding Guo, Liang Guo, Mei Sun, Yangguo Zhao, Mengchun Gao, Zonglian She
Waste activated sludge (WAS) internal carbon source can efficiently and economically enhance denitrification, and hydraulic retention time (HRT) is one of the most important operational parameters for denitrification. The effects of HRT on denitrification were investigated with WAS thermal hydrolysis liquid and acidogenic liquid as carbon sources in this study. The optimal HRT was 12h for thermal hydrolysis liquid and 8h for acidogenic liquid, with NO3(-)-N removal efficiency of 91.0% and 97.6%, respectively...
November 15, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27912959/chinese-herbal-medicine-kuntai-capsule-for-treatment-of-menopausal-syndrome-a-systematic-review-of-randomized-clinical-trials
#4
REVIEW
Quan Zhou, Jing Tao, Huamei Song, Aihua Chen, Huaijie Yang, Manzhen Zuo, Hairong Li
OBJECTIVES: Kuntai capsule has been widely used for the treatment of menopausal syndrome in China for long time. We conducted this review to assess efficacy and safety of Kuntai capsule for the treatment of menopausal syndrome. METHODS: We searched studies in PubMed, ClinicalTrials, the Cochrane Library, China National Knowledge Infrastructure Database(CNKI), China Science and Technology Journal Database (VIP), Wan fang Database and Chinese Biomedical Literature Database(CBM) until November 20, 2014...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912889/hormone-replacement-therapy-in-young-women-with-primary-ovarian-insufficiency-and-early-menopause
#5
REVIEW
Shannon D Sullivan, Philip M Sarrel, Lawrence M Nelson
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone deficiency and infertility in women. In addition to causing infertility, POI is associated with multiple health risks, including bothersome menopausal symptoms, decreased bone density and increased risk of fractures, early progression of cardiovascular disease, psychologic impact that may include depression, anxiety, and decreased perceived psychosocial support, potential early decline in cognition, and dry eye syndrome. Appropriate hormone replacement therapy (HRT) to replace premenopausal levels of ovarian sex steroids is paramount to increasing quality of life for women with POI and ameliorating associated health risks...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27910937/biohydrogen-production-from-enzymatic-hydrolysis-of-food-waste-in-batch-and-continuous-systems
#6
Wei Han, Yingting Yan, Yiwen Shi, Jingjing Gu, Junhong Tang, Hongting Zhao
In this study, the feasibility of biohydrogen production from enzymatic hydrolysis of food waste was investigated. Food waste (solid-to-liquid ratio of 10%, w/v) was first hydrolyzed by commercial glucoamylase to release glucose (24.35 g/L) in the food waste hydrolysate. Then, the obtained food waste hydrolysate was used as substrate for biohydrogen production in the batch and continuous (continuous stirred tank reactor, CSTR) systems. It was observed that the maximum cumulative hydrogen production of 5850 mL was achieved with a yield of 245...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909901/obesity-and-breast-cancer
#7
Renée T Fortner, Verena Katzke, Tilman Kühn, Rudolf Kaaks
The relationship between adiposity and breast cancer risk and prognosis is complex, with associations that differ depending on when body size is assessed (e.g., pre- vs. postmenopausal obesity) and when breast cancer is diagnosed (i.e., pre- vs. postmenopausal disease). Further, the impact of obesity on risk differs by tumor hormone receptor status (e.g., estrogen (ER) and progesterone (PR) receptor) and, among postmenopausal women, use of exogenous hormones (i.e., hormone replacement therapy (HRT)). In the context of these complexities, this review focuses on associations between childhood and adolescent adiposity, general adiposity, weight changes (i...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27906970/poor-compliance-to-hormone-therapy-and-decreased-bone-mineral-density-in-women-with-premature-ovarian-insufficiency
#8
Anne Bachelot, Carole Nicolas, Solenne Gricourt, Jérôme Dulon, Monique Leban, Jean Louis Golmard, Philippe Touraine
Premature ovarian insufficiency leads to through infertility and estrogen deficiency. Optimal management encompasses estrogen replacement therapy. Long-term outcome of women with POI is not known. We design a study to evaluate the medical care, hormone replacement therapy compliance and bone mineral density (BMD) in POI women with at least a five-year follow-up after the first evaluation. One hundred and sixty-two patients (37.3±8.0 years) were evaluated (follow-up 7.9±2.8 years). Sixty-nine patients (42...
2016: PloS One
https://www.readbyqxmd.com/read/27905538/potential-and-optimization-of-two-phase-anaerobic-digestion-of-oil-refinery-waste-activated-sludge-and-microbial-community-study
#9
Qinghong Wang, Ying Liang, Peng Zhao, Qing X Li, Shaohui Guo, Chunmao Chen
Oil refinery waste activated sludge produced from oil wastewater biological treatment is a major industrial sludge. Two-phase anaerobic digestion of oil refinery waste activated sludge was studied for the first time. Thermal pretreatment under 170 °C is effective on sludge solubilization. At the optimum hydrolytic-acidogenic condition which was pH of 6.5, temperature of 55 °C and HRT of 2 days, 2754 mg/L volatile fatty acids (VFAs) were produced and acetic acid and butyric acid were the key components...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900444/effect-of-humic-acid-on-anaerobic-digestion-of-cellulose-and-xylan-in-completely-stirred-tank-reactors-inhibitory-effect-mitigation-of-the-inhibition-and-the-dynamics-of-the-microbial-communities
#10
Samet Azman, Ahmad F Khadem, Caroline M Plugge, Alfons J M Stams, Sabina Bec, Grietje Zeeman
Inhibition effect of humic acid (HA) on anaerobic digestion of cellulose and xylan and the mitigation potential of the inhibition were evaluated in controlled fed batch reactors at 30 °C and a hydraulic retention time (HRT) of 20 days. Reactor performances were evaluated by biogas production and metabolite measurements for 220 days. Microbial population dynamics of the reactors were monitored with next-generation 16S rRNA gene sequencing at nine different sampling times. Our results showed that increasing levels of HA inhibited the hydrolysis efficiency of the digestion by 40% and concomitantly reduced the methane yield...
November 29, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27898316/effects-of-iron-and-calcium-carbonate-on-the-variation-and-cycling-of-carbon-source-in-integrated-wastewater-treatments
#11
Zhao Zhimiao, Song Xinshan, Zhao Yufeng, Xiao Yanping, Wang Yuhui, Wang Junfeng, Yan Denghua
Iron and calcium carbonate were added in wastewater treatments as the adjusting agents to improve the contaminant removal performance and regulate the variation of carbon source in integrated treatments. At different temperatures, the addition of the adjusting agents obviously improved the nitrogen and phosphorous removals. TN and TP removals were respectively increased by 29.41% and 23.83% in AC-100 treatment under 1-day HRT. Carbon source from dead algae was supplied as green microbial carbon source and Fe(2+) was supplied as carbon source surrogate...
November 22, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27892816/optimization-of-the-pretreatment-of-wastewater-from-a-slaughterhouse-and-packing-plant-through-electrocoagulation-in-a-batch-reactor
#12
Fábio Orssatto, Maria Hermínia Ferreira Tavares, Flávia Manente da Silva, Eduardo Eyng, Brendown Faria Biassi, Leandro Fleck
The purpose of this study is to evaluate the removal of COD (chemical oxygen demand), turbidity and color of wastewater from a pig slaughterhouse and packing plant through the electrochemical technique and to optimize the ΔV(electric potential difference) and HRT (hydraulic retention time) variables in an electrocoagulation batch reactor using aluminum electrodes. The experimental design used was RCCD (Rotatable Central Composite Design). The characteristics of the effluent were 4730 mg L(-1) to COD, 0.0 mg L(-1) to total aluminum, 6...
November 28, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27883319/the-effects-of-hormonal-therapy-and-exercise-on-bone-turnover-in-postmenopausal-women-a-randomised-double-blind-pilot-study
#13
Suzy Y Honisett, Kathy Tangalakis, John Wark, Vasso Apostolopoulos, Lily Stojanovska
INTRODUCTION: Hormone replacement therapy (HRT) and walking were investigated independently and in combination, to determine which treatment provided most effect on bone turnover in postmenopausal women. METHODS: Using a randomised double-blind pilot study, 10 subjects received HRT (transdermal estradiol, 50 μg/day and oral MPA 5 mg/day) and 12 received placebo for 20 weeks. Following a baseline period of treatment, both groups undertook a graduated walking regimen, which increased in intensity, duration and frequency parameters from weeks 8-20...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27879279/heart-rate-turbulence-is-a-powerful-predictor-of-cardiac-death-and-ventricular-arrhythmias-in-postmyocardial-infarction-and-heart-failure-patients-a-systematic-review-and-meta-analysis
#14
Marcello Disertori, Michela Masè, Marta Rigoni, Giandomenico Nollo, Flavia Ravelli
BACKGROUND: Heart rate turbulence (HRT) has been proposed as a candidate marker of altered autonomic tone, and some studies showed its prognostic value for both cardiac death (CD) and sudden death. Nevertheless, HRT is not currently used in the clinical practice. METHODS AND RESULTS: We performed a systematic review and meta-analysis of the predictive value of HRT for the end points of total mortality, CD, and fatal and nonfatal ventricular arrhythmias in postacute myocardial infarction and heart failure patients...
December 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27871753/role-of-three-different-plants-on-simultaneous-salt-and-nutrient-reduction-from-saline-synthetic-wastewater-in-lab-scale-constructed-wetlands
#15
João M Jesus, A C Cassoni, Anthony S Danko, António Fiúza, Maria-Teresa Borges
Constructed Wetlands (CWs) can be a valuable technology to treat high salinity wastewaters but it is not known their potential for removal of both nutrients and salt, and the type of plants to use. This study evaluated the effect of three plants on salt reduction and simultaneous nutrient removal in CWs microcosms with expanded clay and in hydroponic conditions. Initial values of the synthetic wastewater tested were EC=15dSm(-1), SAR=151; NH4(+)-N=24mgL(-1); PO4(3-)-P=30mgL(-1) and NO3(-)-N=34mgL(-1). With expanded clay CW removal efficiency for NH4(+)-N was 21, 88 and 85%, while for NO3(-)-N, it was 4, 56 and 68% for Spartina maritima, Juncus maritimus and Arundo donax, respectively...
November 18, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27866347/effect-of-low-intensity-resistance-training-with-heat-stress-on-the-hsp72-anabolic-hormones-muscle-size-and-strength-in-elderly-women
#16
Sung Jin Yoon, Moon Jin Lee, Hyo Min Lee, Jin Seok Lee
BACKGROUND: Several recent studies have reported that heat stress stimulates the activation of heat shock protein 72 (HSP72), leading to an increase in muscle synthesis. Some studies suggested that low-intensity resistance training combined with heat stress could improve muscle size and strength. AIM: This study aimed to identify the effect of low-intensity resistance training with heat stress over 12 weeks on the HSP72, anabolic hormones, muscle size, and strength in elderly women...
November 19, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27863737/intensified-nitrate-and-phosphorus-removal-in-an-electrolysis-integrated-horizontal-subsurface-flow-constructed-wetland
#17
Y Gao, Y W Xie, Q Zhang, A L Wang, Y X Yu, L Y Yang
A novel electrolysis-integrated horizontal subsurface-flow constructed wetland system (E-HFCWs) was developed for intensified removal of nitrogen and phosphorus contaminated water. The dynamics of nitrogen and phosphorus removal and that of main water qualities of inflow and outflow were also evaluated. The hydraulic retention time (HRT) greatly enhanced nitrate removal when the electrolysis current intensity was stabilized at 0.07 mA/cm(2). When the HRT ranged from 2 h to 12 h, the removal rate of nitrate increased from 20% to 84%...
January 1, 2017: Water Research
https://www.readbyqxmd.com/read/27861721/long-term-hormone-replacement-therapy-is-associated-with-low-coronary-artery-calcium-levels-in-a-cohort-of-older-women-the-age-gene-environment-susceptibility-reykjavik-study
#18
Adalsteinn Gudmundsson, Thor Aspelund, Gunnar Sigurdsson, Tamara Harris, Lenore J Launer, Vilmundur Gudnason, Helgi Jonsson
OBJECTIVES: To assess the relationship between hormone replacement therapy (HRT) and coronary artery calcium (CAC). DESIGN: Cross-sectional. SETTING: Established population-based cohort in Reykjavik, Iceland. PARTICIPANTS: Women (mean age 76 ± 5) who had completed questionnaires on HRT use (N = 2,867). MEASUREMENTS: Coronary artery calcium assessed using computed tomography was the outcome variable and was compared between women with history of HRT and those who had never used HRT and analyzed according to age, length of use, and time after menopause that HRT was initiated...
November 11, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27858796/influence-of-hydraulic-retention-time-on-the-psychrophilic-hydrolysis-acidogenesis-of-proteins
#19
Paola Poirrier, María Cristina Schiappacasse, Marta Carballa, Juan M Lema
The influence of the hydraulic retention time (HRT) on the anaerobic hydrolysis of complex substrates has been studied under psychrophilic conditions. For this purpose, a continuous stirred tank reactor was operated at 15 °C and neutral pH and gelatin was considered as a model protein. Three HRTs have been tested: 12, 21 and 36 h. Gelatin hydrolysis was greatly dependent on HRT, increasing from 40% at 12 h-HRT to a maximum of 65% at 36 h-HRT. Molecular size distribution analyses of the effluent showed that hydrolysation of compounds larger than 10 kDa was poor at 12 h-HRT, whereas the fraction of 1-10 kDa was completely transformed into compounds smaller than 1 kDa...
November 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27855327/evaluation-of-anaerobic-sludge-volume-for-improving-azo-dye-decolorization-in-a-hybrid-anaerobic-reactor-with-built-in-bioelectrochemical-system
#20
Min-Hua Cui, Dan Cui, Lei Gao, Ai-Jie Wang, Hao-Yi Cheng
A hybrid anaerobic reactor with built-in bioelectrochemical system (BES) has been verified for efficiently treating mixed azo dye wastewater, yet still facing many challenges, such as uncertain reactor construction and insufficient electron donors. In this study, an up-flow hybrid anaerobic reactor with built-in BES was developed for acid orange 7 (AO7) containing wastewater treatment. Cathode and real domestic wastewater both served as electron donor for driving azo dye decolorization. The decolorization efficiency (DE) of AO7 (200 mg/L) in the hybrid reactor was 80...
November 14, 2016: Chemosphere
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