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https://www.readbyqxmd.com/read/27909582/ebola-research-funding-a-systematic-analysis-1997-2015
#1
Joseph Ra Fitchett, Amos Lichtman, Damilola T Soyode, Ariel Low, Jimena Villar de Onis, Michael G Head, Rifat Atun
BACKGROUND: The latest outbreak of Ebola in West Africa overwhelmed the affected countries, with the impact on health extending far beyond Ebola-related deaths that have exceeded 11 000. The need to promptly mobilise resources to control emerging infections is widely recognized. Yet, data on research funding for emerging infections remains inadequately documented. METHODS: We defined research investment as all funding flows for Ebola and/or Marburg virus from 1997 to April 2015 whose primary purpose was to advance knowledge and new technologies to prevent or cure disease...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27864803/enabling-rapid-response-to-the-2014-2016-ebola-epidemic-the-experience-and-the-results-of-the-national-institute-for-infectious-diseases-lazzaro-spallanzani
#2
Emanuele Nicastri, Concetta Castilletti, Mirella Biava, Francesco Maria Fusco, Nicola Petrosillo, Vincenzo Puro, Francesco Nicola Lauria, Maria Rosaria Capobianchi, Antonino Di Caro, Giuseppe Ippolito
The unprecedented epidemic of Ebola virus disease (EVD) in West Africa highlighted the need for stronger systems for disease surveillance, response, and prevention worldwide. Tackling an epidemic event today requires a broader view, not only limited to medical management of the patients, but which also includes heroic efforts by clinicians and public health personnel.Since its foundation in 1936, INMI has been devoted to the prevention, diagnosis and care for infectious diseases. In 2009, INMI became a WHO collaborative center for clinical care, diagnosis, response and training on Highly Infectious Diseases...
November 19, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27855644/febrile-illness-diagnostics-and-the-malaria-industrial-complex-a-socio-environmental-perspective
#3
Justin Stoler, Gordon A Awandare
BACKGROUND: Global prioritization of single-disease eradication programs over improvements to basic diagnostic capacity in the Global South have left the world unprepared for epidemics of chikungunya, Ebola, Zika, and whatever lies on the horizon. The medical establishment is slowly realizing that in many parts of sub-Saharan Africa (SSA), particularly urban areas, up to a third of patients suffering from acute fever do not receive a correct diagnosis of their infection. MAIN BODY: Malaria is the most common diagnosis for febrile patients in low-resource health care settings, and malaria misdiagnosis has soared due to the institutionalization of malaria as the primary febrile illness of SSA by international development organizations and national malaria control programs...
November 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27849507/deployment-of-the-1st-area-medical-laboratory-in-a-split-based-configuration-during-the-largest-ebola-outbreak-in-history
#4
Anthony P Cardile, Christopher T Littell, Michael G Backlund, Richard A Heipertz, Jerod A Brammer, Sean M Palmer, Todd J Vento, Felix A Ortiz, William R Rosa, Michael J Major, Patrick M Garman
BACKGROUND: The U.S. Army 1(st) Area Medical Laboratory (1(st) AML) is currently the only deployable medical CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosives) laboratory in the Army's Forces Command. In support of the United States Agency for International Development Ebola response, the U.S. military initiated Operation United Assistance (OUA), and deployed approximately 2,500 service members to support the Government of Liberia's Ebola control efforts. Due to its unique molecular diagnostic and expeditionary capabilities, the 1(st) AML was ordered to deploy in October of 2014 in support of OUA via establishment of Ebola testing laboratories...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27846221/minimally-symptomatic-infection-in-an-ebola-hotspot-a-cross-sectional-serosurvey
#5
Eugene T Richardson, J Daniel Kelly, Mohamed Bailor Barrie, Annelies W Mesman, Sahr Karku, Komba Quiwa, Regan H Marsh, Songor Koedoyoma, Fodei Daboh, Kathryn P Barron, Michael Grady, Elizabeth Tucker, Kerry L Dierberg, George W Rutherford, Michele Barry, James Holland Jones, Megan B Murray, Paul E Farmer
INTRODUCTION: Evidence for minimally symptomatic Ebola virus (EBOV) infection is limited. During the 2013-16 outbreak in West Africa, it was not considered epidemiologically relevant to published models or projections of intervention effects. In order to improve our understanding of the transmission dynamics of EBOV in humans, we investigated the occurrence of minimally symptomatic EBOV infection in quarantined contacts of reported Ebola virus disease cases in a recognized 'hotspot.' METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional serosurvey in Sukudu, Kono District, Sierra Leone, from October 2015 to January 2016...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27818362/impact-of-infectious-disease-epidemics-on-tuberculosis-diagnostic-management-and-prevention-services-experiences-and-lessons-from-the-2014-2015-ebola-virus-disease-outbreak-in-west-africa
#6
Rashid Ansumana, Samuel Keitell, Gregory M T Roberts, Francine Ntoumi, Eskild Petersen, Giuseppe Ippolito, Alimuddin Zumla
The World Health Organization (WHO) annual TB report states twenty-eight percent of the world's 9.6 million new tuberculosis (TB) cases are in the WHO Africa Region. The Mano River Union (MRU) countries of West Africa, Guinea, Sierra Leone and Liberia, have over the past two decades made incremental sustained investments into TB control programs. The devastating 2014-2015 Ebola Virus Disease (EVD) outbreak in West Africa impacted significantly on all sectors of the healthcare systems in the MRU countries, including the TB prevention and control programs...
November 3, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27815125/meeting-report-29th-international-conference-on-antiviral-research-in-la-jolla-ca-usa
#7
REVIEW
R Anthony Vere Hodge
The 29th International Conference on Antiviral Research (ICAR) was held in La Jolla, CA, USA from April 17 to 21, 2016. This report opens with a tribute to the late Chris McGuigan, a Past-President of ISAR, then continues with summaries of the principal invited lectures. Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holý Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV...
November 1, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27808119/directional-and-reoccurring-sequence-change-in-zoonotic-rna-virus-genomes-visualized-by-time-series-word-count
#8
Yoshiko Wada, Kennosuke Wada, Yuki Iwasaki, Shigehiko Kanaya, Toshimichi Ikemura
Ebolavirus, MERS coronavirus and influenza virus are zoonotic RNA viruses, which mutate very rapidly. Viral growth depends on many host factors, but human cells may not provide the ideal growth conditions for viruses invading from nonhuman hosts. The present time-series analyses of short and long oligonucleotide compositions in these genomes showed directional changes in their composition after invasion from a nonhuman host, which are thought to recur after future invasions. In the recent West Africa Ebola outbreak, directional time-series changes in a wide range of oligonucleotides were observed in common for three geographic areas, and the directional changes were observed also for the recent MERS coronavirus epidemics starting in the Middle East...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807010/an-outbreak-inside-an-epidemic-managing-an-infectious-disease-outbreak-while-treating-ebola
#9
REVIEW
Simon Horne, K Forbes, D Burns, Jjh Tuck
Even in the middle of an epidemic of a very serious illness, outbreaks of other infectious diseases will continue. Clinicians need to be able to make rapid decisions about the nature of the outbreak and how to manage it. A balance needs to be struck between managing all patients as if they have the worst-case scenario illness and the resultant risks to themselves, their colleagues and the mission. This paper reviews basic epidemiological tools that inform robust decision-making in the management of such outbreaks...
November 2, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27795350/development-of-a-sensitive-and-specific-serological-assay-based-on-the-luminex-technology-for-the-detection-of-antibodies-to-zaire-ebola-virus-ebov
#10
Ahidjo Ayouba, Abdoulaye Touré, Christelle Butel, Alpha Kabinet Keita, Florian Binetruy, Mamadou S Sow, Vincent Foulongne, Eric Delaporte, Martine Peeters
The recent Ebola virus outbreak in West Africa illustrates clearly the need for additional studies in humans and animals to elucidate the ecology of Ebola viruses. Here we developed a serological assay based on the Luminex technology. Nine recombinant proteins representing different viral regions (NP, VP40 and GP) from four of the five EBV lineages were used. Samples from 94 survivors of the EBOV outbreak in Guinea and negative samples from 108 patients in France were used to calculate test performance for EBOV detection and cross-reaction with other Ebola virus lineages...
October 26, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27795340/comparison-of-magpix%C3%A2-%C3%A2-assays-and-elisa-for-the-detection-of-hemorrhagic-fever-viruses
#11
Neal G Satterly, Matthew A Voorhees, Abbe D Ames, Randal J Schoepp
Viral hemorrhagic fevers with their high mortality rates, lack of medical countermeasures, and potential use as instruments of bioterrorism, pose a significant threat to the developed and the developing areas of the world. The key to preventing the spread of these diseases is early and accurate detection. For decades, the gold-standard immunoassay for hemorrhagic fever detection has been the ELISA; however newer technologies are emerging with increased sensitivity. One such technology is the Luminex MAGPIX®™ platform using XMAP® microspheres...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27788135/diagnostics-in-ebola-virus-disease-in-resource-rich-and-resource-limited-settings
#12
REVIEW
Robert J Shorten, Colin S Brown, Michael Jacobs, Simon Rattenbury, Andrew J Simpson, Stephen Mepham
The Ebola virus disease (EVD) outbreak in West Africa was unprecedented in scale and location. Limited access to both diagnostic and supportive pathology assays in both resource-rich and resource-limited settings had a detrimental effect on the identification and isolation of cases as well as individual patient management. Limited access to such assays in resource-rich settings resulted in delays in differentiating EVD from other illnesses in returning travellers, in turn utilising valuable resources until a diagnosis could be made...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27787490/preparedness-for-zika-virus-disease-new-york-city-2016
#13
Syra S Madad, Joseph Masci, Nicholas V Cagliuso, Machelle Allen
The rapid spread of Zika virus across the World Health Organization's Region of the Americas has had a direct effect on the U.S. health care delivery system. Hospitals in New York City (NYC) have been implementing prevention and response efforts consistent with CDC guidance. As of September 21, 2016, a total of 715 cases of laboratory-confirmed Zika virus disease had been diagnosed in New York state among travelers who returned from affected areas, their sexual contacts, or infants infected in utero. This represents the highest number of reported cases in any state to date, and underscores the importance of health care systems preparing to care for patients with possible Zika virus disease (1)...
October 28, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27773059/ebola-viruses-the-challenges-of-developing-and-implementing-diagnostics-for-dangerous-emerging-pathogens
#14
David W Smith
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27716429/serosurveillance-of-viral-pathogens-circulating-in-west-africa
#15
Aileen E O'Hearn, Matthew A Voorhees, David P Fetterer, Nadia Wauquier, Moinya R Coomber, James Bangura, Joseph N Fair, Jean-Paul Gonzalez, Randal J Schoepp
BACKGROUND: Sub-Saharan Africa is home to a variety of pathogens, but disease surveillance and the healthcare infrastructure necessary for proper management and control are severely limited. Lassa virus, the cause of Lassa fever, a severe hemorrhagic fever in humans is endemic in West Africa. In Sierra Leone at the Kenema Government Hospital Lassa Diagnostic Laboratory, up to 70 % of acute patient samples suspected of Lassa fever test negative for Lassa virus infection. This large amount of acute undiagnosed febrile illness can be attributed in part to an array of hemorrhagic fever and arthropod-borne viruses causing disease that goes undetected and untreated...
October 3, 2016: Virology Journal
https://www.readbyqxmd.com/read/27709137/recent-trends-on-hydrogel-based-drug-delivery-systems-for-infectious-diseases
#16
Arti Vashist, Ajeet Kaushik, Atul Vashist, Rahul Dev Jayant, Asahi Tomitaka, Sharif Ahmad, Y K Gupta, Madhavan Nair
Since centuries, the rapid spread and cure of infectious diseases have been a major concern to the progress and survival of humans. These diseases are a global burden and the prominent cause for worldwide deaths and disabilities. Nanomedicine has emerged as the most excellent tool to eradicate and halt their spread. Various nanoformulations (NFs) using advanced nanotechnology are in demand. Recently, hydrogel and nanogel based drug delivery devices have posed new prospects to simulate the natural intelligence of various biological systems...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27707892/laboratory-response-to-2014-ebola-virus-outbreak-in-mali
#17
Bassirou Diarra, David Safronetz, Yeya Dit Sadio Sarro, Amadou Kone, Moumine Sanogo, Sady Tounkara, Antieme C G Togo, Fatoumata Daou, Almoustapha I Maiga, Sounkalo Dao, Kyle Rosenke, Darryl Falzarano, Seydou Doumbia, Kathryn C Zoon, Michael Polis, Sophia Siddiqui, Samba Sow, Tom G Schwan, Heinz Feldmann, Souleyman Diallo, Ousmane A Koita
Aware of the rapid spread of Ebola virus (EBOV) during the current West African epidemic, Mali took several proactive steps to rapidly identify cases within its borders. Under the Mali International Center for Excellence in Research program, a collaboration between the National Institute of Allergy and Infectious Diseases and the Malian Ministry of Higher Education and Scientific Research established a national EBOV diagnostic site at the University of Sciences, Techniques and Technologies of Bamako in the SEREFO Laboratory...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27698289/monitoring-and-managing-mental-health-in-the-wake-of-ebola-commentary
#18
Byron Kiiza Yafesi Bitanihirwe
Infectious disease continues to have dramatic effects on morbidity and mortality around the world. Few events could cause such loss of life and damage to livelihoods. As witnessed with the recent West African Ebola outbreak, raising alerts and identifying the outbreak in the community took too long. As a consequence local health systems were quickly overwhelmed. In addition, response at the international level proved slow and poorly coordinated. Rapid diagnostics, effective therapeutics, protective equipment, and a vaccine were all lacking...
July 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27694364/educating-health-care-providers-in-treatment-of-patients-with-ebola-virus-disease
#19
Ellen J Eckes, Debbie Gutierrez, Ann Peterson, Melissa Hubbard, Kevin Barrett, Ann Marie Matlock
Nurses manage patients with common infectious diseases by following institutional guidelines based on expert advice, evidence in the literature, and a wealth of experience. Today nurses are challenged to provide care to patients with multidrug-resistant organisms and virulent infectious diseases such as Ebola virus disease. Management of some patients with virulent infectious diseases occurs in the context of minimal experience with the pathogen, course of infection, diagnostics, nursing care, and treatment...
October 2016: Critical Care Nurse
https://www.readbyqxmd.com/read/27646649/impact-of-the-mass-drug-administration-for-malaria-in-response-to-the-ebola-outbreak-in-sierra-leone
#20
Maru Aregawi, Samuel J Smith, Musa Sillah-Kanu, John Seppeh, Anitta R Y Kamara, Ryan O Williams, John J Aponte, Andrea Bosman, Pedro Alonso
BACKGROUND: As emergency response to the Ebola epidemic, the Government of Sierra Leone and its partners implemented a large-scale Mass Drug Administration (MDA) with artesunate-amodiaquine (ASAQ) covering >2.7 million people in the districts hardest hit by Ebola during December 2014-January 2015. The World Health Organization (WHO) and the National Malaria Control Programme (NMCP) evaluated the impact of the MDA on malaria morbidity at health facilities and the number of Ebola alerts received at District Ebola Command Centres...
2016: Malaria Journal
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