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https://www.readbyqxmd.com/read/29053626/a-systematic-review-of-computational-drug-discovery-development-and-repurposing-for-ebola-virus-disease-treatment
#1
REVIEW
James Schuler, Matthew L Hudson, Diane Schwartz, Ram Samudrala
Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches to find or develop drugs that target the Ebola virus and synthesize its results. A variety of hypothesized and/or novel treatments are reported to have potential anti-Ebola activity. Approaches that utilize multi-targeting/polypharmacology have the most promise in treating EVD...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29049274/reporting-deaths-among-children-aged-5-years-after-the-ebola-virus-disease-epidemic-bombali-district-sierra-leone-2015-2016
#2
Amanda L Wilkinson, Reinhard Kaiser, Mohamed F Jalloh, Mamudi Kamara, Dianna M Blau, Pratima L Raghunathan, Alpha Kamara, Umaru Kamara, Nathaniel Houston-Suluku, Kevin Clarke, Amara Jambai, John T Redd, Sara Hersey, Brima Osaio-Kamara
Mortality surveillance and vital registration are limited in Sierra Leone, a country with one of the highest mortality rates among children aged <5 years worldwide, approximately 120 deaths per 1,000 live births (1,2). To inform efforts to strengthen surveillance, stillbirths and deaths in children aged <5 years from multiple surveillance streams in Bombali Sebora chiefdom were retrospectively reviewed. In total, during January 2015-November 2016, 930 deaths in children aged <5 years were identified, representing 73...
October 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29047180/systematic-screening-of-viral-entry-inhibitors-using-surface-plasmon-resonance
#3
REVIEW
Penmetcha K R Kumar
Viral binding and entry into host cells for various viruses have been studied extensively, yielding a detailed understanding of the overall viral entry process. As cell entry is an essential and requisite process by which a virus initiates infection, it is an attractive target for therapeutic intervention. The advantages of targeting viral entry are an extracellular target site, relatively easy access for biological interventions, and lower toxicity. Several cell-based strategies and biophysical techniques have been used to screen compounds that block viral entry...
October 18, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29034663/-anthropology-engaged-against-ebola-2014-2016-approaches-contributions-and-new-questions
#4
Alice Desclaux, Julienne Anoko
Anthropologists contributed to the response to the 2014-2016 Ebola outbreak in three ways : as Ebola experts, cultural mediators between populations and caregivers, and researchers. This article presents a preliminary review of approaches, contributions and related issues based on a literature review, case studies and debates. The anthropological research discussed in this article concerns four themes : epidemiological contexts of transmission ; cultural interpretation of illness and social responses ; social construction of stakeholders' experience ; critical analysis of public health interventions...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29034662/-the-lessons-of-the-ebola-epidemic-for-a-more-effective-preparedness-face-to-health-crises
#5
Anne Fortin, Joseph Vroh Benie Bi, Abdelkrim Soulimane
Although uncommon, public health crises cause considerable human suffering and death and have major political, economic and social impacts. For many years, countries have made considerable efforts to prepare for emergencies. The Ebola epidemic in West Africa, as well as recent events and emerging public health threats force countries to strengthen, adapt or implement their Emergency Preparedness Plans. Emergency Preparedness is a difficult process. Some authors would even say that it is an impossible mission...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29032747/development-of-potential-small-molecule-therapeutics-for-treatment-of-ebola-virus
#6
Adam Michael Schafer, Han Cheng, Charles Lee, Ruikun Du, Julianna Han, Jasmine Perez, Norton Peet, Balaji Manicassamy, Lijun Rong
Ebola virus has caused 26 outbreaks in 10 different countries since its identification in 1976, making it one of the deadliest emerging viral pathogens. The most recent outbreak in West Africa from 2014-16 was the deadliest yet and culminated in 11,310 deaths out of 28,616 confirmed cases. Currently there are no FDA-approved therapeutics or vaccines to treat Ebola virus infections. The slow development of effective vaccines combined with the severity of past outbreaks emphasizes the need to accelerate research into understanding the virus lifecycle and the development of therapeutics for post exposure treatment...
October 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29028879/review-of-computational-methods-for-virus-host-protein-interaction-prediction-a-case-study-on-novel-ebola-human-interactions
#7
Anup Kumar Halder, Pritha Dutta, Mahantapas Kundu, Subhadip Basu, Mita Nasipuri
Identification of potential virus-host interactions is useful and vital to control the highly infectious virus-caused diseases. This may contribute toward development of new drugs to treat the viral infections. Recently, database records of clinically and experimentally validated interactions between a small set of human proteins and Ebola virus (EBOV) have been published. Using the information of the known human interaction partners of EBOV, our main objective is to identify a set of proteins that may interact with EBOV proteins...
September 26, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29026397/role-of-contact-tracing-in-containing-the-2014-ebola-outbreak-a-review
#8
Shrivastava Saurabh, Shrivastava Prateek
BACKGROUND: The 2014 outbreak of Ebola virus disease which emerged in the month of March in the year 2014 in Guinea has been declared as a public health emergency of international concern. OBJECTIVES: The objectives of the review article are to assess the role of contact tracing in the Ebola outbreak and to identify the challenges faced by the health workers while performing contact tracing. METHODS: An extensive search of all materials related to the Ebola outbreak and contact tracing was carried out in PubMed, Medline, World Health Organization website and Google Scholar search engines...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29017587/the-perspective-of-gender-on-the-ebola-virus-using-a-risk-management-and-population-health-framework-a-scoping-review
#9
REVIEW
Miriam N Nkangu, Oluwasayo A Olatunde, Sanni Yaya
BACKGROUND: In the three decades since the first reported case of Ebola virus, most known index cases have been consistently traced to the hunting of "bush meat", and women have consistently recorded relatively high fatality rates in most catastrophic outbreaks. This paper discusses Ebola-related risk factors, which constantly interact with cultural values, and provides an insight into the link between gender and the risk of contracting infectious diseases, using Ebola virus as an example within Africa...
October 11, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29017275/the-response-of-the-peer-review-system-to-the-ebola-and-zika-virus-epidemic
#10
Andreas Ronit
No abstract text is available yet for this article.
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28994617/an-interim-examination-of-the-us-public-health-response-to-ebola
#11
Katherine Schemm Dwyer, Heather Misner, Sara Chang, Neyling Fajardo
From the summer of 2014 to the spring of 2016, the United States was involved in the Ebola response on both the national and international levels. The United States received 2 imported cases from West Africa and had 2 locally hospital-acquired cases, which spurred a massive and unprecedented public health response. As the domestic response stabilized and the epidemic in West Africa slowed, the Association of State and Territorial Health Officials (ASTHO) and the National Association of County and City Health Officials (NACCHO), through a cooperative agreement with the Centers for Disease Control and Prevention (CDC), led an in-progress review to assess the national public health response to Ebola...
October 10, 2017: Health Security
https://www.readbyqxmd.com/read/28939358/recrudescence-of-ebola-virus-disease-outbreak-in-west-africa-2014-2016
#12
Hyojung Lee, Hiroshi Nishiura
OBJECTIVES: There have been errors in determining the end of the Ebola virus disease (EVD) epidemic when adhering to the criteria of the World Health Organization. The present study aimed to review and learn from all known recrudescence events in West Africa occurring in 2014-2016. METHODS: Background mechanisms of five erroneous declarations in Guinea, Liberia, and Sierra Leone during 2014-2016 were reviewed. RESULTS: Three cases of recrudescence were suspected to have been caused by sexual contact with survivors, one to be due to international migration, and one was linked to a potentially immunocompromised mother...
September 20, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28937795/using-mystery-patient-drills-to-assess-hospital-ebola-preparedness-in-new-york-city-2014-2015
#13
Mary Foote, Roshni Daver, Celia Quinn
In response to the Ebola virus disease (EVD) outbreak in West Africa, rapid measures were taken to ensure readiness at frontline New York City (NYC) healthcare facilities, including mandating monthly EVD mystery patient drills to test screening protocols. This study analyzed after-action reports to describe the use of mystery patient drills to test rapid identification and isolation of potential EVD cases in NYC emergency departments. NYC hospitals were required to develop protocols for EVD screening and isolation, and to conduct drills with an actor presenting to the emergency department with symptoms suggestive of EVD...
September 22, 2017: Health Security
https://www.readbyqxmd.com/read/28930167/host-transcriptional-response-to-ebola-virus-infection
#14
REVIEW
Emily Speranza, John H Connor
Ebola virus disease (EVD) is a serious illness that causes severe disease in humans and non-human primates (NHPs) and has mortality rates up to 90%. EVD is caused by the Ebolavirus and currently there are no licensed therapeutics or vaccines to treat EVD. Due to its high mortality rates and potential as a bioterrorist weapon, a better understanding of the disease is of high priority. Multiparametric analysis techniques allow for a more complete understanding of a disease and the host response. Analysis of RNA species present in a sample can lead to a greater understanding of activation or suppression of different states of the immune response...
September 20, 2017: Vaccines
https://www.readbyqxmd.com/read/28929318/monitoring-and-evaluating-the-ebola-response-effort-in-two-liberian-communities
#15
Davison Munodawafa, Matshidiso Rebecca Moeti, Peter Malekele Phori, Stephen B Fawcett, Ithar Hassaballa, Charles Sepers, Florence DiGennaro Reed, Jerry A Schultz, Ephraim Tafadzwa Chiriseri
Although credited with ultimately reducing incidence of Ebola Virus Disease (EVD) in West Africa, little is known about the amount and kind of Ebola response activities associated with reducing the incidence of EVD. Our team monitored Ebola response activities and associated effects in two rural counties in Liberia highly affected by Ebola. We used a participatory monitoring and evaluation system, and drew upon key informant interviews and document review, to systematically capture, code, characterize, and communicate patterns in Ebola response activities...
September 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28903457/the-lifecycle-of-the-ebola-virus-in-host-cells
#16
REVIEW
Dong-Shan Yu, Tian-Hao Weng, Xiao-Xin Wu, Frederick X C Wang, Xiang-Yun Lu, Hai-Bo Wu, Nan-Ping Wu, Lan-Juan Li, Hang-Ping Yao
Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28899284/identifying-and-addressing-the-governance-accountability-problem
#17
Annamarie Bindenagel Šehović
Successive global health crises - from HIV and AIDS to SARS and H5N1 to Ebola - highlight one of the most pressing challenges to global health security: the GAP - the governance accountability problem. Introduced in 2014 in the book entitled, HIV/AIDS and the South African state: The responsibility to respond, this article takes up Alan Whiteside's challenges, in a book review in these pages, to offer a more comprehensive analysis of the GAP. The GAP [Šehović, A. B. (2014). HIV/AIDS and the South African state: The responsibility to respond...
September 13, 2017: Global Public Health
https://www.readbyqxmd.com/read/28890666/discovering-drugs-for-the-treatment-of-ebola-virus
#18
REVIEW
Sandra L Bixler, Allen J Duplantier, Sina Bavari
PURPOSE OF REVIEW: Ebola virus, a member of the Filoviridae family, is a causative agent of severe viral hemorrhagic fever in humans. Over the past 40 years, the virus has been linked to several high mortality outbreaks in Africa with the recent West African outbreak resulting in over 11,000 deaths. This review provides a summary of the status of the drug discovery and development process for therapeutics for Ebola virus disease, with a focus on the strategies being used and the challenges facing each stage of the process...
2017: Current Treatment Options in Infectious Diseases
https://www.readbyqxmd.com/read/28890191/considerations-for-use-of-ebola-vaccine-during-an-emergency-response
#19
REVIEW
Jenny A Walldorf, Emily A Cloessner, Terri B Hyde, Adam MacNeil
Vaccination against Ebola virus disease is a tool that may limit disease transmission and deaths in future outbreaks, integrated within traditional Ebola outbreak prevention and control measures. Although a licensed Ebolavirus vaccine (EV) is not yet available, the 2014-2016 West African Ebola outbreak has accelerated EV clinical trials and given public health authorities in Guinea, Liberia, and Sierra Leone experience with implementation of emergency ring vaccination. As evidence supporting the use of EV during an outbreak response has become available, public health authorities in at-risk countries are considering how to integrate EV into future emergency Ebola responses and for prevention in high-risk groups, such as healthcare workers and frontline workers (HCW/FLWs), even before an EV is licensed...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28882724/evaluation-of-the-scientific-impact-of-the-ebola-epidemic-a-systematic-review
#20
REVIEW
Nico T Mutters, Veronika Malek, Selidji T Agnandji, Frank Günther, Evelina Tacconelli
OBJECTIVES: The Ebola outbreak prompted an extensive number of scientific publications. Yet little attention has been paid to the involvement of scientific communities, the scientific impact as well as provided funding. We sought to systematically review publicly available information on the scientific impact of the Ebola epidemic. METHODS: A systematic review of scientific literature was performed. Information on the scientific impact of the Ebola epidemic including the involvement of scientific communities by determining the origins, funding, and impact factor (IF) of publications between December 6, 2013, and December 22, 2015 were included...
September 4, 2017: Clinical Microbiology and Infection
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