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Cranberry juice

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https://www.readbyqxmd.com/read/27921450/oral-pharmacokinetic-interaction-of-ester-rich-fruit-juices-and-pharmaceutical-excipients-with-tenofovir-disoproxil-fumarate-in-male-wistar-rats
#1
Joseph Shailender, Punna Rao Ravi, Paramita Saha, Srividya Myneni
The aim of this study was to evaluate the role of intestinal esterases on the absorption process of tenofovir disoproxil fumarate (TDF). The esterase inhibition capacity of fruit juices (FJs) rich in ester linkages and pharmaceutical excipients (having ester) was performed in vitro by incubating TDF with each FJ and excipient in the intestinal washings. The ex vivo everted gut sac model was also used to evaluate the absorption enhancement capacity of these FJs and excipients. Single dose oral pharmacokinetic studies were performed by concomitant administration of TDF with each of the selected FJs and excipients...
December 6, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27889156/survival-of-hepatitis-a-virus-and-aichi-virus-in-cranberry-based-juices-at-refrigeration-4%C3%A2-%C3%A2-c
#2
Snigdha Sewlikar, Doris H D'Souza
Viral foodborne illness continues to be a health-concern globally, with numerous fruit and juice outbreaks of Hepatitis A virus (HAV) reported worldwide. Aichi virus (AiV) is an emerging pathogen with limited epidemiological data. Both, HAV and AiV are resistant to low pH and can survive under adverse environmental conditions leading to transmission ease. The objective of this study was to evaluate the survival of HAV and AiV in commercially-available cranberry-based juices (Cranberry juice cocktail, CJ and a 100% juice with cranberry, MJ) over 21 days at refrigeration (4 °C)...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27866177/cranberries-for-preventing-recurrent-urinary-tract-infections-in-uncircumcised-boys
#3
Kong-Sang Wan, Chih-Kuang Liu, Wen-Kai Lee, Ming-Chung Ko, Che-Sheng Huang
Background • Highly concentrated cranberry juice has long been considered to have protective properties against urinary tract infections (UTIs), on the basis of its content of cranberry proanthocyanidins, with A-type interflavan bonds. Objective • This study intended to evaluate the benefits of a highly concentrated cranberry juice for the prevention of repeated episodes of UTI in uncircumcised boys. Design • The study was a randomized, controlled trial. Setting • The study took place at Taipei City Hospital, Renai and Zhongxing Branches (Taipei City, Taiwan)...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27787564/effect-of-cranberry-capsules-on-bacteriuria-plus-pyuria-among-older-women-in-nursing-homes-a-randomized-clinical-trial
#4
Manisha Juthani-Mehta, Peter H Van Ness, Luann Bianco, Andrea Rink, Sabina Rubeck, Sandra Ginter, Stephanie Argraves, Peter Charpentier, Denise Acampora, Mark Trentalange, Vincent Quagliarello, Peter Peduzzi
Importance: Bacteriuria plus pyuria is highly prevalent among older women living in nursing homes. Cranberry capsules are an understudied, nonantimicrobial prevention strategy used in this population. Objective: To test the effect of 2 oral cranberry capsules once a day on presence of bacteriuria plus pyuria among women residing in nursing homes. Design, Setting, and Participants: Double-blind, randomized, placebo-controlled efficacy trial with stratification by nursing home and involving 185 English-speaking women aged 65 years or older, with or without bacteriuria plus pyuria at baseline, residing in 21 nursing homes located within 50 miles (80 km) of New Haven, Connecticut (August 24, 2012-October 26, 2015)...
November 8, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27778523/the-multifunctionality-of-berries-toward-blood-platelets-and-the-role-of-berry-phenolics-in-cardiovascular-disorders
#5
Beata Olas
Diet and nutrition have an important influence on the prophylaxis and progression of cardiovascular disease; one example is the inhibition of blood platelet functions by specific components of fruits and vegetables. Garlic, onion, ginger, dark chocolate and polyunsaturated fatty acids all reduce blood platelet aggregation. A number of fruits contain a range of cardioprotective antioxidants and vitamins, together with a large number of non-nutrient phytochemicals such as phenolic compounds, which may possess both antioxidant properties and anti-platelet activity...
October 25, 2016: Platelets
https://www.readbyqxmd.com/read/27739084/multidimensional-comparative-analysis-of-phenolic-compounds-in-organic-juices-with-high-antioxidant-capacity
#6
Dariusz Nowak, Michał Gośliński, Artur Szwengiel
BACKGROUND: A diet rich in fruit, vegetables and juices is associated with health benefit and reduced risk of certain civilization diseases. Antioxidant properties depend mainly on the total content of polyphenols and their composition. The aim of this study was to perform a multidimensional comparative analysis of phenolic compounds of organic juices with high antioxidant capacity (chokeberry, elderberry, cranberry, pomegranate). RESULTS: All the analyzed juices were a rich source of phenolic compounds...
October 14, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27719908/effect-of-ultrasound-followed-by-high-pressure-processing-on-prebiotic-cranberry-juice
#7
Wesley Faria Gomes, Brijesh Kumar Tiwari, Óscar Rodriguez, Edy Sousa de Brito, Fabiano André Narciso Fernandes, Sueli Rodrigues
This work evaluated the effect of high pressure processing (HPP) and ultrasound (US) on the quality of prebiotic cranberry juice fortified with fructo-oligosaccharides (FOS). The juice was subjected to HPP for 5min (450MPa) and to ultrasonic treatment for 5min (600 and 1200W/L) followed by HPP for 5min (450MPa). Chemical analyses were carried out to identify and quantify the anthocyanins, and to quantify FOS, organic acids, instrumental color, soluble solids, pH and antioxidant capacity. Both non-thermal treatments preserved the FOS content maintaining the prebiotic property of the juice...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27690414/urinary-clearance-of-cranberry-flavonol-glycosides-in-humans
#8
Yifei Wang, Ajay P Singh, Heather N Nelson, Amanda J Kaiser, Nicolette C Reker, Tisha L Hooks, Ted Wilson, Nicholi Vorsa
Cranberry is reported to have health benefits including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 ml cranberry juice containing flavonol glycosides. Urine samples were collected at 0, 90, 225 and 360 minutes post-ingestion. While flavan-3-ols were not detected, five flavonol glycosides common in cranberry were identified...
October 3, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27587728/potential-immunomodulatory-effects-of-non-dialyzable-materials-of-cranberry-extract-in-poultry-production
#9
Md Rashedul Islam, Dave B Oomah, Moussa S Diarra
Studies on effects of cranberry products in animals, especially in chickens, are very scarce or even lacking. This study investigated the immunomodulatory effect of high molecular weight non-dialyzable materials (NDMs) of cranberry extract. The in vitro antioxidant and anti-inflammatory activities were investigated. The ability of NDMs (0, 1, 2, or 4 mg/mL) to enhance phagocytic activities was also evaluated using chicken heterophils (CHEs) against Staphylococcus aureus Furthermore, a broiler model was used to determine the effect of NDMs on the humoral immune response...
September 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/27527878/development-and-validation-of-a-high-throughput-micro-solid-phase-extraction-method-coupled-with-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-for-rapid-identification-and-quantification-of-phenolic-metabolites-in
#10
Rodrigo P Feliciano, Elsa Mecha, Maria R Bronze, Ana Rodriguez-Mateos
A rapid and high-throughput micro-solid phase extraction (μ-SPE) method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC Q-TOF MS) analysis was optimized and validated for the quantification of 67 (poly)phenol metabolites in human plasma and urine using authentic standards. The method was fully validated in terms of specificity, linearity, method detection limit (MDL), method quantification limit (MQL), repeatability, intra- and inter-day precision, accuracy and matrix effects...
September 16, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27456160/study-of-the-impact-of-cranberry-extract-on-the-virulence-factors-and-biofilm-formation-by-enterococcus-faecalis-strains-isolated-from-urinary-tract-infections
#11
Dorota Wojnicz, Dorota Tichaczek-Goska, Kamila Korzekwa, Marta Kicia, Andrzej B Hendrich
Drinking of cranberry fruit juice and application of commercial preparations containing the cranberry extracts are recommended in the prevention and treatment of urinary tract infections (UTIs), especially in women with recurrent UTIs. Many studies focus on the activity of cranberries against uropathogenic Escherichia coli (E. coli) strains. However, the knowledge of the cranberry effect on Gram-positive Enterococcus faecalis (E. faecalis) is limited. Therefore, the aim of our study was to establish the activity of commercial concentrated cranberry extract on the growth, virulence factors and biofilm formation of E...
December 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27335715/suspected-interaction-of-cranberry-juice-extracts-and-tacrolimus-serum-levels-a-case-report
#12
Atman A Dave, Jones Samuel
Cytochrome P450 inhibition through fruit supplement interactions often results in increased serum levels of calcineurin inhibitors, including tacrolimus. Cranberry extract is a supplement often used for the prevention of recurrent urinary tract infections (UTIs), which are common in renal allograft recipients. To our knowledge, a decrease in serum levels of tacrolimus as a result of cranberry extract interaction is unreported. A 40-year-old renal transplant patient taking cranberry extract capsules for her recurrent cystitis presented asymptomatically with low serum levels of tacrolimus...
2016: Curēus
https://www.readbyqxmd.com/read/27299641/reduction-of-enteric-viruses-by-blueberry-juice-and-blueberry-proanthocyanidins
#13
Snehal S Joshi, Amy B Howell, Doris H D'Souza
Blueberry and blueberry extracts are known for their health benefits and antimicrobial properties. Natural therapeutic or preventive options to decrease the incidences of foodborne viral illnesses are becoming popular and being researched. This study aimed to determine the antiviral effects of blueberry juice (BJ) and blueberry proanthocyanidins (BB-PAC, B-type PAC structurally different from A-type PAC found in cranberries) against the infectivity of hepatitis A virus (HAV) and human norovirus surrogates (feline calicivirus (FCV-F9) and murine norovirus (MNV-1)) at 37 °C over 24 h using standard plaque assays...
June 14, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27251185/consumption-of-a-cranberry-juice-beverage-lowered-the-number-of-clinical-urinary-tract-infection-episodes-in-women-with-a-recent-history-of-urinary-tract-infection
#14
Kevin C Maki, Kerrie L Kaspar, Christina Khoo, Linda H Derrig, Arianne L Schild, Kalpana Gupta
BACKGROUND: Urinary tract infections (UTIs) are among the most common bacterial infections and are often treated with antibiotics. Concerns about multidrug-resistant uropathogens have pointed to the need for safe and effective UTI-prevention strategies such as cranberry consumption. OBJECTIVE: We assessed the effects of the consumption of a cranberry beverage on episodes of clinical UTIs. DESIGN: In this randomized, double-blind, placebo-controlled, multicenter clinical trial, women with a history of a recent UTI were assigned to consume one 240-mL serving of cranberry beverage/d (n = 185) or a placebo (n = 188) beverage for 24 wk...
June 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27242317/cranberry-poly-phenol-metabolites-correlate-with-improvements-in-vascular-function-a-double-blind-randomized-controlled-dose-response-crossover-study
#15
Ana Rodriguez-Mateos, Rodrigo P Feliciano, Albert Boeres, Timon Weber, Claudia Nunes Dos Santos, M Rita Ventura, Christian Heiss
SCOPE: Cranberries are rich in potentially bioactive (poly)phenols. The aim of this work was to investigate whether cranberry juice intake can improve vascular function in healthy men in a dose- and time-dependent manner, and to understand which of the circulating (poly)phenol metabolites correlate with vascular effects. METHODS AND RESULTS: A double-blind randomized controlled crossover trial was conducted in 10 healthy males. Flow-mediated dilation (FMD), blood pressure, pulse wave velocity and augmentation index were investigated at baseline, 1, 2, 4, 6, and 8h post-consumption of cranberry juices containing 409, 787, 1238, 1534, and 1910 mg of total cranberry (poly)phenols (TP), and a control drink...
May 31, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27220364/atomic-force-microscopy-guided-fractionation-reveals-the-influence-of-cranberry-phytochemicals-on-adhesion-of-escherichia-coli
#16
Prachi Gupta, Biqin Song, Catherine Neto, Terri A Camesano
Cranberry juice has been long used to prevent infections because of its effect on the adhesion of the bacteria to the host surface. Proanthocyanidins (PACs) comprise of one of the major classes of phytochemicals found in cranberry, which have been extensively studied and found effective in combating adhesion of pathogenic bacteria. The role of other cranberry constituents in impacting bacterial adhesion haven't been studied very well. In this study, cranberry juice fractions were prepared, characterized and tested for their effect on the surface adhesion of the pathogenic clinical bacterial strain E...
June 15, 2016: Food & Function
https://www.readbyqxmd.com/read/27211666/gallic-acid-as-a-protective-antioxidant-against-anthocyanin-degradation-and-color-loss-in-vitamin-c-fortified-cranberry-juice
#17
Sunisa Roidoung, Kirk D Dolan, Muhammad Siddiq
The objective of this study was to evaluate different antioxidants for anthocyanin (ACY) retention in vitamin C fortified cranberry juice and assess its quality. Cranberry juice was fortified with 40-80mg/100mL vitamin C and added hesperidin, catechin, and gallic acid at different concentrations. Juice was pasteurized at 85°C for 1min and stored at 23°C for 16days. ACYs, vitamin C, color intensity, and browning index (BI) were evaluated at 2-day intervals. Gallic acid was found to be the most effective antioxidant against ACYs degradation and significantly (p<0...
November 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27107382/effects-of-cranberry-components-on-il-1%C3%AE-stimulated-production-of-il-6-il-8-and-vegf-by-human-tmj-synovial-fibroblasts
#18
David A Tipton, James Christian, Adam Blumer
OBJECTIVE: Osteoarthritis (OA) in the TMJ is characterized by deterioration of articular cartilage and secondary inflammatory changes. Interleukin-1β (IL-1β) stimulates IL-6, IL-8, and vascular endothelial growth factor (VEGF) in synovial fluid of TMJ with internal derangement and bony changes. The cranberry (Vaccinium macrocarpon) contains polyphenolic compounds that inhibit production of pro-inflammatory molecules by gingival cells in response to several stimulators. This study examined effects of cranberry components on IL-1β-stimulated IL-6, IL-8, and VEGF production by human TMJ synovial fibroblast-like cells...
August 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27090825/cranberry-derivatives-enhance-biofilm-formation-and-transiently-impair-swarming-motility-of-the-uropathogen-proteus-mirabilis-hi4320
#19
Che O'May, Olivier Amzallag, Karim Bechir, Nathalie Tufenkji
Proteus mirabilis is a major cause of catheter-associated urinary tract infection (CAUTI), emphasizing that novel strategies for targeting this bacterium are needed. Potential targets are P. mirabilis surface-associated swarming motility and the propensity of these bacteria to form biofilms that may lead to catheter blockage. We previously showed that the addition of cranberry powder (CP) to lysogeny broth (LB) medium resulted in impaired P. mirabilis swarming motility over short time periods (up to 16 h). Herein, we significantly expanded on those findings by exploring (i) the effects of cranberry derivatives on biofilm formation of P...
June 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27085566/prevention-of-urinary-tract-infection-with-oximacro-a-cranberry-extract-with-a-high-content-of-a-type-proanthocyanidins-a-pre-clinical-double-blind-controlled-study
#20
Andrea Occhipinti, Antonio Germano, Massimo E Maffei
PURPOSE: Urinary tract infections (UTIs) are widespread and affect a large portion of the human population. Cranberry juices and extracts have been used for UTI prevention due to their content of bioactive proanthocyanidins (PACs), particularly of the A type (PAC-A). Controversial clinical results obtained with cranberry are often due to a lack of precise determination and authentication of the PAC-A content. This study used Oximacro (Biosfered S.r.l., Turin, Italy), a cranberry extract with a high content of PAC-A, to prevent UTIs in female and male volunteers...
March 2016: Urology Journal
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