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"Implementation science"

Madhukar Pai, Mark P Nicol, Catharina C Boehme
Rapid and accurate diagnosis is critical for timely initiation of anti-tuberculosis (TB) treatment, but many people with TB (or TB symptoms) do not have access to adequate initial diagnosis. In many countries, TB diagnosis is still reliant on sputum microscopy, a test with known limitations. However, new diagnostics are starting to change the landscape. Stimulated, in part, by the success and rollout of Xpert MTB/RIF, an automated, molecular test, there is now considerable interest in new technologies. The landscape looks promising with a pipeline of new tools, particularly molecular diagnostics, and well over 50 companies actively engaged in product development, and many tests have been reviewed by WHO for policy endorsement...
October 2016: Microbiology Spectrum
Sandy Middleton, Chris Levi, Simeon Dale, N Wah Cheung, Elizabeth McInnes, Julie Considine, Catherine D'Este, Dominique A Cadilhac, Jeremy Grimshaw, Richard Gerraty, Louise Craig, Verena Schadewaldt, Patrick McElduff, Mark Fitzgerald, Clare Quinn, Greg Cadigan, Sonia Denisenko, Mark Longworth, Jeanette Ward
BACKGROUND: Internationally recognised evidence-based guidelines recommend appropriate triage of patients with stroke in emergency departments (EDs), administration of tissue plasminogen activator (tPA), and proactive management of fever, hyperglycaemia and swallowing before prompt transfer to a stroke unit to maximise outcomes. We aim to evaluate the effectiveness in EDs of a theory-informed, nurse-initiated, intervention to improve multidisciplinary triage, treatment and transfer (T(3)) of patients with acute stroke to improve 90-day death and dependency...
October 18, 2016: Implementation Science: IS
Aliki Thomas, André Bussières
No abstract text is available yet for this article.
October 4, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Sairam Parthasarathy, Mary A Carskadon, Girardin Jean-Louis, Judith Owens, Adam Bramoweth, Daniel Combs, Lauren Hale, Elizabeth Harrison, Chantelle N Hart, Brant P Hasler, Sarah M Honaker, Elisabeth Hertenstein, Samuel Kuna, Clete Kushida, Jessica C Levenson, Caitlin Murray, Allan I Pack, Vivek Pillai, Kristi Pruiksma, Azizi Seixas, Patrick Strollo, Saurabh S Thosar, Natasha Williams, Daniel Buysse
A wealth of scientific knowledge is being generated in sleep and circadian science. In order for us to realize the return on investment for such scientific knowledge and to improve the health of the nation, we need to disseminate and implement research findings into practice. An implementation gap - termed a "quality chasm" by the Institutes of Medicine - separates the scientific knowledge we possess and the implementation of such knowledge into preventative interventions or healthcare treatments. It is frequently reported that a time lag of 17 years transpires before medical research reaches clinical practice...
October 10, 2016: Sleep
Curtis H Weiss, Jerry A Krishnan, David H Au, Bruce G Bender, Shannon S Carson, Adithya Cattamanchi, Michelle M Cloutier, Colin R Cooke, Karen Erickson, Maureen George, Joe K Gerald, Lynn B Gerald, Christopher H Goss, Michael K Gould, Robert Hyzy, Jeremy M Kahn, Brian S Mittman, Erika M Mosesón, Richard A Mularski, Sairam Parthasarathy, Sanjay R Patel, Cynthia S Rand, Nancy S Redeker, Theodore F Reiss, Kristin A Riekert, Gordon D Rubenfeld, Judith A Tate, Kevin C Wilson, Carey C Thomson
BACKGROUND: Many advances in health care fail to reach patients. Implementation science is the study of novel approaches to mitigate this evidence-to-practice gap. METHODS: The American Thoracic Society (ATS) created a multidisciplinary ad hoc committee to develop a research statement on implementation science in pulmonary, critical care, and sleep medicine. The committee used an iterative consensus process to define implementation science and review the use of conceptual frameworks to guide implementation science for the pulmonary, critical care, and sleep community and to explore how professional medical societies such as the ATS can promote implementation science...
October 15, 2016: American Journal of Respiratory and Critical Care Medicine
Douglas A Luke, Ana A Baumann, Bobbi J Carothers, John Landsverk, Enola K Proctor
BACKGROUND: Training investigators for the rapidly developing field of implementation science requires both mentoring and scientific collaboration. Using social network descriptive analyses, visualization, and modeling, this paper presents results of an evaluation of the mentoring and collaborations fostered over time through the National Institute of Mental Health (NIMH) supported by Implementation Research Institute (IRI). METHODS: Data were comprised of IRI participant self-reported collaborations and mentoring relationships, measured in three annual surveys from 2012 to 2014...
October 13, 2016: Implementation Science: IS
Louise Hull, Thanos Athanasiou, Stephanie Russ
OBJECTIVE: The aim of this review was to emphasize the importance of implementation science in understanding why efforts to integrate evidence-based interventions into surgical practice frequently fail to replicate the improvements reported in early research studies. SUMMARY OF BACKGROUND DATA: Over the past 2 decades, numerous patient safety initiatives have been developed to improve the quality and safety of surgical care. The surgical community is now faced with translating "promising" initiatives from the research environment into clinical practice-the World Health Organization (WHO) has described this task as one of the greatest challenges facing the global health community and has identified the importance of implementation science in scaling up evidence-based interventions...
October 4, 2016: Annals of Surgery
Prerna G Arora, Elizabeth H Connors, Melissa W George, Aaron R Lyon, Courtney B Wolk, Mark D Weist
Evidence-based assessment (EBA) is a critically important aspect of delivering high-quality, school-based mental health care for youth. However, research in this area is limited and additional applied research on how best to support the implementation of EBA in school mental health (SMH) is needed. Accordingly, this manuscript seeks to facilitate the advancement of research on EBA in SMH by reviewing relevant literature on EBA implementation in schools and providing recommendations for key research priorities...
October 11, 2016: Clinical Child and Family Psychology Review
Sarah Kearney, Loksee Leung, Andrew Joyce, Debbie Ollis, Celia Green
Issue addressed: Our Watch led a complex 12-month evaluation of a whole school approach to Respectful Relationships Education (RRE) implemented in 19 schools. RRE is an emerging field aimed at preventing gender-based violence. This paper will illustrate how from an implementation science perspective, the evaluation was a critical element in the change process at both a school and policy level.Methods: Using several conceptual approaches from systems science, the evaluation sought to examine how the multiple systems layers - student, teacher, school, community and government - interacted and influenced each other...
October 6, 2016: Health Promotion Journal of Australia
Mary E Northridge, Sara S Metcalf
BACKGROUND: Implementation science holds promise for better ensuring that research is translated into evidence-based policy and practice, but interventions often fail or even worsen the problems they are intended to solve due to a lack of understanding of real world structures and dynamic complexity. While systems science alone cannot possibly solve the major challenges in public health, systems-based approaches may contribute to changing the language and methods for conceptualising and acting within complex systems...
October 4, 2016: Health Research Policy and Systems
Luke Wolfenden, Jannah Jones, Christopher M Williams, Meghan Finch, Rebecca J Wyse, Melanie Kingsland, Flora Tzelepis, John Wiggers, Amanda J Williams, Kirsty Seward, Tameka Small, Vivian Welch, Debbie Booth, Sze Lin Yoong
BACKGROUND: Despite the existence of effective interventions and best-practice guideline recommendations for childcare services to implement policies, practices and programmes to promote child healthy eating, physical activity and prevent unhealthy weight gain, many services fail to do so. OBJECTIVES: The primary aim of the review was to examine the effectiveness of strategies aimed at improving the implementation of policies, practices or programmes by childcare services that promote child healthy eating, physical activity and/or obesity prevention...
October 4, 2016: Cochrane Database of Systematic Reviews
Traci H Abraham, Eleanor T Lewis, Karen L Drummond, Christine Timko, Michael A Cucciare
: Aim To better understand barriers and facilitators that hinder or help women veterans discuss their alcohol use with providers in primary care in order to better identify problematic drinking and enhance provider-patient communication about harmful drinking. BACKGROUND: Women presenting to primary care may be less likely than men to disclose potentially harmful alcohol use. No studies have qualitatively examined the perspectives of primary care providers about factors that affect accurate disclosure of alcohol use by women veterans during routine clinic visits...
October 3, 2016: Primary Health Care Research & Development
Prerna G Arora, Elizabeth H Connors, Angela Blizzard, Kelly Coble, Nicole Gloff, David Pruitt
Increased attention has been placed on evaluating the extent to which clinical programs that support the behavioral health needs of youth have effective processes and result in improved patient outcomes. Several theoretical frameworks from dissemination and implementation (D&I) science have been put forth to guide the evaluation of behavioral health program implemented in the context of real-world settings. Although a strong rationale for the integration of D&I science in program evaluation exists, few examples exist available to guide the evaluator in integrating D&I science in the planning and execution of evaluation activities...
September 20, 2016: Evaluation and Program Planning
Lei Cheng, Sheng Feng, Yan Hu
BACKGROUND: It is crucial to identify the challenges of evidence-based nursing implementation faced by countries in transitional stage. PURPOSE: The purpose of this study was to identify the state of evidence on implementation in Chinese nursing contexts and to determine gaps that need to be pursued. METHODS: We performed a scoping review on existing literature on implementation studies conducted in nursing context in Mainland China. After systematically searching eight (four Chinese and four English) databases, we extracted and analyzed data from the included studies...
August 24, 2016: Nursing Outlook
Mandeep R Mehra
No abstract text is available yet for this article.
September 19, 2016: Journal of Cardiac Failure
Aaron R Lyon, Cara C Lewis, Abigail Melvin, Meredith Boyd, Semret Nicodimos, Freda F Liu, Nathaniel Jungbluth
BACKGROUND: Health information technologies (HIT) have become nearly ubiquitous in the contemporary healthcare landscape, but information about HIT development, functionality, and implementation readiness is frequently siloed. Theory-driven methods of compiling, evaluating, and integrating information from the academic and commercial sectors are necessary to guide stakeholder decision-making surrounding HIT adoption and to develop pragmatic HIT research agendas. This article presents the Health Information Technologies-Academic and Commercial Evaluation (HIT-ACE) methodology, a structured, theory-driven method for compiling and evaluating information from multiple sectors...
2016: Implementation Science: IS
Kate Curtis, Margaret Fry, Ramon Z Shaban, Julie Considine
AIMS AND OBJECTIVES: To describe the importance of, and methods for, successfully conducting and translating research into clinical practice. BACKGROUND: There is universal acknowledgment that the clinical care provided to individuals should be informed on the best available evidence. Knowledge and evidence derived from robust scholarly methods should drive our clinical practice, decisions and change to improve the way we deliver care. Translating research evidence to clinical practice is essential to safe, transparent, effective and efficient healthcare provision and meeting the expectations of patients, families and society...
September 20, 2016: Journal of Clinical Nursing
Karriem S Watson, Amanda C Blok, Joanna Buscemi, Yamile Molina, Marian Fitzgibbon, Melissa A Simon, Lance Williams, Kameron Matthews, Jamie L Studts, Sarah E Lillie, Jamie S Ostroff, Lisa Carter-Harris, Robert A Winn
The Society of Behavioral Medicine (SBM) supports the United States Preventive Services Task Force (USPSTF) recommendation of low-dose computed tomography (LDCT) screening of the chest for eligible populations to reduce lung cancer mortality. Consistent with efforts to translate research findings into real-world settings, SBM encourages health-care providers and health-care systems to (1) integrate evidence-based tobacco treatment as an essential component of LDCT-based lung cancer screening, (2) examine the structural barriers that may impact screening uptake, and (3) incorporate shared decision-making as a clinical platform to facilitate consultations and engagement with individuals at high risk for lung cancer about the potential benefits and harms associated with participation in a lung cancer screening program...
September 19, 2016: Translational Behavioral Medicine
Avrum Spira, Mary L Disis, John T Schiller, Eduardo Vilar, Timothy R Rebbeck, Rafael Bejar, Trey Ideker, Janine Arts, Matthew B Yurgelun, Jill P Mesirov, Anjana Rao, Judy Garber, Elizabeth M Jaffee, Scott M Lippman
Prevention is an essential component of cancer eradication. Next-generation sequencing of cancer genomes and epigenomes has defined large numbers of driver mutations and molecular subgroups, leading to therapeutic advances. By comparison, there is a relative paucity of such knowledge in premalignant neoplasia, which inherently limits the potential to develop precision prevention strategies. Studies on the interplay between germ-line and somatic events have elucidated genetic processes underlying premalignant progression and preventive targets...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Janet K Williams, W Gregory Feero, Debra G B Leonard, Bernice Coleman
Implementation of genomic discoveries into health care optimally includes evaluation of outcomes for recipients of care, providers, payers, and health care systems. However, the influence of specific aspects of the implementation process on observed outcomes may be missed if assessment of implementation success is not built into the implementation design. The intersection of implementation science with genomics may provide new insights on how to maximize the benefits of emerging genomic technologies in health care...
August 20, 2016: Nursing Outlook
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