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https://www.readbyqxmd.com/read/28419180/impact-of-gestational-nicotine-exposure-on-intrauterine-and-fetal-infection-in-a-rodent-model1
#1
Maria von Chamier, Leticia Reyes, Linda F Hayward, Mary B Brown
We investigated the interaction between prenatal nicotine exposure and intrauterine infection using established rat models. Beginning at gestation day (GD) 6, dams were continuously infused with either saline or 6 mg/kg/day nicotine (Nic). At GD 14, dams received either sterile broth or 105 CFU Mycoplasma pulmonis (MP), resulting in 4 treatment groups: Control (4 dams, 33 fetal units); MP only (5 dams, 55 fetal units); Nic only (5 dams, 61 fetal units) and Nic + MP (7 dams, 82 fetal units). At GD 18, nicotine exposure significantly increased (P ≤ 0...
April 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28416042/earthquakes-fuel-crisis-power-outages-and-health-care-in-nepal-implications-for-the-future
#2
Bipin Adhikari, Shiva Raj Mishra, Sujan Babu Marahatta, Nils Kaehler, Kumar Paudel, Janak Adhikari, Shristi Raut
Earthquakes are a major natural calamity with pervasive effects on human life and nature. Similar effects are mimicked by man-made disasters such as fuel crises and power outages in developing countries. Natural and man-made disasters can cause intangible human suffering and often leave scars of lifelong psychosocial damage. Lessons from these disasters are frequently not implemented. The main objective of this study was to review the effects of the 2015 earthquakes, fuel crisis, and power outages on the health services of Nepal and formulate recommendations for the future...
April 18, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28414165/recognising-out-of-hospital-cardiac-arrest-during-emergency-calls-increases-bystander-cardiopulmonary-resuscitation-and-survival
#3
Søren Viereck, Thea Palsgaard Møller, Annette Kjær Ersbøll, Josefine Stokholm Bækgaard, Andreas Claesson, Jacob Hollenberg, Fredrik Folke, Freddy K Lippert
BACKGROUND: Initiation of early bystander cardiopulmonary resuscitation (CPR) depends on bystanders' or medical dispatchers' recognition of out-of-hospital cardiac arrest (OHCA). The primary aim of our study was to investigate if OHCA recognition during the emergency call was associated with bystander CPR, return of spontaneous circulation (ROSC), and 30-day survival. Our secondary aim was to identify patient-, setting-, and dispatcher-related predictors of OHCA recognition. METHODS: We performed an observational study of all OHCA patients' emergency calls in the Capital Region of Denmark from 01/01/2013-31/12/2013...
April 14, 2017: Resuscitation
https://www.readbyqxmd.com/read/28412843/continuous-ecg-monitoring-in-patients-with-acute-coronary-syndrome-or-heart-failure-easi-versus-gold-standard
#4
Loreto Lancia, Andrea Toccaceli, Cristina Petrucci, Silvio Romano, Maria Penco
The purpose of the study was to compare the EASI system with the standard 12-lead surface electrocardiogram (ECG) for the accuracy in detecting the main electrocardiographic parameters (J point, PR, QT, and QRS) commonly monitored in patients with acute coronary syndromes or heart failure. In this observational comparative study, 253 patients who were consecutively admitted to the coronary care unit with acute coronary syndrome or heart failure were evaluated. In all patients, two complete 12-lead ECGs were acquired simultaneously...
April 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28412028/-effectiveness-of-erlotinib-in-critical-care-unit-in-patients-with-non-small-cell-lung-cancer-with-egfr-mutation
#5
M Dewolf, C Dayen, C Garoute, W Khamis, M Fourrier, F Rousselle, M Sadki, F Le Meunier, R Suguenot, E Lecuyer, H Bentayeb, Y Douadi, P Berna
INTRODUCTION: The search for mutations epidermal growth factor receptor (EGFR) has changed the therapeutic approach and prognosis of non-small cell lung cancer (NSCLC). The effectiveness of tyrosine kinase inhibitors (TKI) has been demonstrated orally in patients with EGFR mutation. We report the case of a patient for whom treatment with TKI was started effectively in a Critical Care Unit. OBSERVATION: A patient of 59 years is followed for a stage IV lung adenocarcinoma with metastases in liver, brain, adrenal, lung and pleura...
April 12, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28405984/a-prospective-study-of-acute-kidney-injury-according-to-kdigo-definition-and-its-mortality-predictors
#6
Rakesh Bhadade, Rosemarie De'Souza, Minal J Harde, Kalpana S Mehta, Prabhat Bhargava
BACKGROUND: Acute kidney injury is no longer considered to be an innocent bystander merely reflecting co-existent pathologies but an independent risk factor for mortality in the ICU. AIMS AND OBJECTIVES: To study clinical profile and correlation of patients with acute kidney injury (AKI) according to KDIGO definition with respect to incidence, outcome and different causes of AKI in critical care unit. STUDY DESIGN AND SETTING: It is a prospective observational study; and was carried out in the ICU of a tertiary care, teaching, public hospital...
December 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28403118/validation-of-intensive-care-and-mechanical-ventilation-codes-in-medicare-data
#7
Hannah Wunsch, Andrew Kramer, Hayley B Gershengorn
OBJECTIVES: To assess the reliability of codes relevant to critically ill patients in administrative data. DESIGN: Retrospective cohort study linking data from Acute Physiology and Chronic Health Evaluation Outcomes, a clinical database of ICU patients with data from Medicare Provider Analysis and Review. We linked data based on matching for sex, date of birth, hospital, and date of admission to hospital. SETTING: Forty-six hospitals in the United States participating in Acute Physiology and Chronic Health Evaluation Outcomes...
April 11, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28398589/reducing-the-incidence-of-pressure-ulcers-in-critical-care-units-a-4-year-quality-improvement
#8
Annette Richardson, Joanna Peart, Stephen E Wright, Iain J McCullagh
Quality problem: Critical care patients often have several risk factors for pressure ulceration and implementing prevention interventions have been shown to decrease risk. Initial assessment: We identified a high incidence of pressure ulcers in the four adult critical care units in our organization. Therefore, avoiding pressure ulceration was an important quality priority. Choice of solution: We undertook a quality improvement programme aimed at reducing the incidence of pressure ulceration using an evidence-based bundle approach...
April 7, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28397363/improved-time-to-notification-of-impending-brain-death-and-increased-organ-donation-using-an-electronic-clinical-decision-support-system
#9
J L Zier, A B Spaulding, M Finch, T Verschaetse, R Tarrago
Early referral of patients to an organ procurement organization (OPO) may positively impact donation outcomes. We implemented an electronic clinic decision support (CDS) system to automatically notify our OPO of children meeting clinical triggers indicating impending brain death. Medical records of all patients who died in a pediatric critical care unit or were referred for imminent death for three years prior to installation of the initial CDS (pre-CDS) and for one year after implementation of the final CDS (post-CDS) were reviewed...
April 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28396656/prescription-patterns-for-tigecycline-in-severely-ill-patients-for-non-fda-approved-indications-in-a-developing-country-a-compromised-outcome
#10
Rima A Moghnieh, Dania I Abdallah, Ismail A Fawaz, Tarek Hamandi, Mohammad Kassem, Nabila El-Rajab, Tamima Jisr, Anas Mugharbil, Nabila Droubi, Samaa Al Tabah, Loubna Sinno, Fouad Ziade, Ziad Daoud, Ahmad Ibrahim
Introduction: With the rise in antibiotic resistance, tigecycline has been used frequently in off-label indications, based on its in-vitro activity against multidrug-resistant organisms. In this study, our aim was to assess its use in approved and unapproved indications. Materials and Methods: This is a retrospective chart review evaluating a 2-year experience of tigecycline use for > 72 h in 153 adult patients inside and outside critical care unit from January 2012 to December 2013 in a Lebanese tertiary-care hospital...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28389120/reference-equations-for-handgrip-strength-normative-values-in-young-adult-and-middle-aged-subjects
#11
Jordão Lopes, Samantha Torres Grams, Edy Floriano da Silva, Luana Adriano de Medeiros, Christina May Moran de Brito, Wellington Pereira Yamaguti
BACKGROUND & AIMS: Handgrip strength (HS) has been widely used as a functionality parameter of the upper limbs (UL) and general health. The measurement of HS by dynamometry is a low cost, non-invasive method of simple applicability, widely used in pulmonary rehabilitation and in critical care units. However, there are no reports in the literature of reference equations for the Brazilian population involving young and middle-aged adults. The aim of this study was to establish reference equations to predict normal HS for young and middle-aged adults through demographic and anthropometric data...
March 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28385368/-ambient-noise-comparison-in-2-intensive-care-units-in-a-tertiary-care-center
#12
José Manuel Ornelas-Aguirre, Olivia Zárate-Coronado, Fabiola Gaxiola-González, Venigna Neyoy-Sombra
INTRODUCTION: The World Health Organization has established a maximum noise level of 40 decibels (dB) for an intensive care unit. The aim of this study was to compare the noise level in 2 different intensive care units at a tertiary care center. METHODS: In an cross-sectional design, the maximum noise level was analyzed within the intensive coronary care unit and intensive care unit with a digital meter. A measurement in 4 different points of each room with 5minute intervals for a period of 60minutes were performed at 7:30, 14:30 and 20:30...
April 3, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28384600/a-prospective-study-of-fungal-biomarkers-to-improve-management-of-invasive-fungal-diseases-in-a-mixed-specialty-critical-care-unit
#13
Alida Fe Talento, Katie Dunne, Eimear Ann Joyce, Michael Palmer, Elizabeth Johnson, P Lewis White, Jan Springer, Juergen Loeffler, Thomas Ryan, Daniel Collins, Thomas R Rogers
PURPOSE: The diagnosis of invasive fungal diseases (IFD) in critical care patients (CrCP) is difficult. The study investigated the performance of a set of biomarkers for diagnosis of IFD in a mixed specialty critical care unit (CrCU). METHODS: A prospective observational study in patients receiving critical care for ≥7days was performed. Serum samples were tested for the presence of: (1-3) - β-d-glucan (BDG), galactomannan (GM), and Aspergillus fumigatus DNA...
March 30, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28377021/triggers-and-timing-of-acute-coronary-syndromes
#14
Geoffrey H Tofler, Eran Kopel, Robert Klempfner, Michael Eldar, Thomas Buckley, Ilan Goldenberg
Previous studies have shown that an acute coronary syndrome (ACS) may be triggered by external activities; however, their frequency, predictors, and significance are uncertain. We evaluated data from the National Israel Survey of Acute Coronary Syndromes, which was conducted in 2004 (February to March) in all 25 coronary care units and cardiac wards in Israel. Demographic and clinical data were recorded for consecutive participants, including potential triggers and time of symptom onset of ACS. Among the 1,849 patients who completed the trigger question, 1/4 (25...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28375996/listening-to-how-experienced-nurses-care-for-the-dying-husband-and-his-spouse
#15
Lana McLouth Kanacki, Betty Wehtje Winslow
BACKGROUND: Although most nurses in critical care settings provide nursing care for marital couples when 1 of the partners is dying, this is a relatively new area of research. OBJECTIVE: The aim of this study is to describe the nature of nursing care provided for marital couples in the critical care unit when the husbands were dying. METHOD: A qualitative interpretive description was used to construct this study. Data were collected by conducting semistructured individual interviews with 15 experienced critical care nurses in quiet conference rooms...
May 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28374341/the-frequency-and-nature-of-medication-errors-in-hospitalized-patients-with-acute-coronary-syndrome
#16
Mostafa A Sayed Ali, Christina Milad Lobos, Mohamed Aboel-Kassem F Abdelmegid, Ahmed Moustafa El-Sayed
Background Cardiovascular medications have been commonly associated with medication errors. Objective The objective of this study was to investigate the incidence and predictors of medication errors in patients with acute coronary syndrome. Setting the coronary care unit of a university teaching hospital. Methods This was a prospective observational study on 150 patients admitted to the coronary care unit between August 2014 and July 2015. Main outcome measure The principal outcome was the number (frequency) of encountered medication errors...
April 3, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28374334/long-term-outcome-of-patients-with-liver-cirrhosis-admitted-to-a-general-intensive-care-unit
#17
Alex Warren, Charlotte R Soulsby, Alex Puxty, Joseph Campbell, Martin Shaw, Tara Quasim, John Kinsella, Joanne McPeake
OBJECTIVES: The prevalence of liver cirrhosis is increasing, and many patients have acute conditions requiring consideration of intensive care. This study aims to: (a) report the outcome at 12 months of patients with cirrhosis admitted to ICU, (b) identify factors predictive of long-term mortality and (c) evaluate the ability of scoring systems to predict long-term outcome. DESIGN: Observational cohort study. SETTING: General adult critical care unit in a UK teaching hospital...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28366521/nurses-perceptions-of-reasons-for-persistent-low-rates-in-hand-hygiene-compliance
#18
Nohemi Sadule-Rios, Graciela Aguilera
AIM: The purpose of this study was to explore nurses' perceptions of reasons for persistent low rates in hand hygiene compliance in the Critical Care Unit and their recommendations for improvement. DESIGN AND METHODS: This study used an exploratory, descriptive survey design to identify critical care nurses' perceptions of barriers to hand hygiene compliance in the unit and their recommendations for improvement. RESULTS: Nurses selected high workload, understaffing and suggested lack of time as the main problems with hand hygiene compliance in the critical care unit...
March 30, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28363594/thematic-analysis-how-do-patient-diaries-affect-survivors-psychological-recovery
#19
REVIEW
Angela Teece, John Baker
AIM: This review aims to use thematic analysis to explore and synthesise evidence of the actual or potential reported effects of diaries on the psychological rehabilitation and recovery of discharged critical care patients. BACKGROUND: Evidence suggests that whilst admission to critical care may save patient lives, the psychological aftermath can damage a patient's recovery and these needs must be met. Patient diaries are one potential intervention to aid patients understand their critical illness and fill memory gaps caused by sedation, thus reducing psychological distress post-discharge...
March 28, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28357636/probable-catastrophic-antiphospholipid-syndrome-with-intracerebral-hemorrhage-secondary-to-epstein-barr-viral-infection
#20
Mark P Plummer, Adam M H Young, Ronan O'Leary, Maxwell S Damian, Andrea Lavinio
BACKGROUND: Catastrophic antiphospholipid syndrome (CAPS) is a rare, severe variant of antiphospholipid syndrome with a high mortality rate. We report a unique case of CAPS secondary to Epstein-Barr viral (EBV) infection complicated by pulmonary and intracerebral hemorrhage. A review of the CAPS literature relevant to intensive care practice is used to outline a rational approach to diagnosis and management. METHODS: All data are from a single patient admitted to the Neurosciences Critical Care Unit in Addenbrooke's Hospital, Cambridge, in March 2016...
March 29, 2017: Neurocritical Care
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