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Mitsuhide Naruse, Hironobu Umakoshi, Mika Tsuiki, Maki Yokomoto, Tetsuya Tagami, Akiyo Tanabe, Akira Shimatsu
Differentiation of unilateral from bilateral aldosterone hypersecretion is the essential step in the clinical practice of primary aldosteronism (PA). Although adrenal venous sampling (AVS) has been established as the most standard test recommended by the guideline, its invasive and technically difficult nature has facilitated the approach to develop non-invasive functioning imaging as an alternative test. Compared to the conventional adrenocortical scintigraphy with cholesterol derivatives as tracer, the first-generation imaging, both of (11)C-MTO/PET and (123)I-IMTO/SPECT/CT, the second-generation imaging, bind with high specificity and affinity to CYP11B enzymes and have advantages in shortening the time for obtaining specific images, reducing the radiation exposure to the patient, and resolution of the images...
November 23, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Erin E Burns, Barbara K Keith, Mohammed Y Refai, Brian Bothner, William E Dyer
Plants are routinely confronted with numerous biotic and abiotic stressors, and in response have evolved highly effective strategies of systemic acquired resistance (SAR) and systemic acquired acclimation (SAA), respectively. A much more evolutionarily recent abiotic stress is the application of herbicides to control weedy plants, and their intensive use has selected for resistant weed populations that cause substantial crop yield losses and increase production costs. Non-target site resistance (NTSR) to herbicides is rapidly increasing worldwide and is associated with alterations in generalized stress defense networks...
November 20, 2017: Journal of Plant Physiology
Mia Kibel, Meredith Vanstone
When evaluating new morally complex health technologies, policy decision-makers consider a broad range of different evaluations, which may include the technology's clinical effectiveness, cost effectiveness, and social or ethical implications. This type of holistic assessment is challenging, because each of these evaluations may be grounded in different and potentially contradictory assumptions about the technology's value. One such technology where evaluations conflict is Non-Invasive Prenatal Testing (NIPT)...
November 16, 2017: Social Science & Medicine
Analia Iriel, Stijn P Bruneel, Nahuel Schenone, Alicia Fernández Cirelli
The use of natural sorbents to remove fluoride from drinking water is a promising alternative because of its low-cost and easy implementation. In this article, fluoride adsorption on a latosol soil from Misiones province (Argentina) was studied regarding kinetic and equilibrium aspects. Experiments were conducted in batch at room temperature under controlled conditions of pH 4-8) and ionic strength (1-10mM KNO3). Experimental data indicated that adsorption processes followed a PSO kinetic where initial rates have showed to be influenced by pH solution...
November 20, 2017: Ecotoxicology and Environmental Safety
Guo-Qiang Chen, Xiao-Ran Jiang
Biosynthesis of polyhydroxyalkanoates (PHA) has been studied since the 1920s. The biosynthesis pathways have been well understood and various attempts have been made to improve the PHA biosynthesis efficiency. Recent progresses have been focused on systematic improvements on PHA biosynthesis including changing growth pattern for rapid proliferation, engineering to enlarge cell sizes for more PHA accumulation space, reprogramming the PHA synthesis pathways using optimized RBS and promoter, redirecting metabolic flux to PHA synthesis using CRISPR/Cas9 tools, and very importantly, the employment of non-traditional host such as halophiles for reduced complexity on PHA production...
November 20, 2017: Current Opinion in Biotechnology
Haleema Alamri, Abdullah Al-Shahrani, Enrico Bovero, Turki Khaldi, Gasan Alabedi, Waleed Obaid, Ihsan Al-Taie, Aziz Fihri
Inspired by the self-cleaning lotus leaf, a facile method of fabricating superhydrophobic silica coated magnetite nanoparticles using a cost-effective process is presented in this work. The structural characterizations and magnetic properties of the obtained core-shell magnetic nanoparticles were characterized by means of X-ray diffraction (XRD), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). TEM analysis revealed that the particles present flower-like dendrimeric fibers morphology...
November 15, 2017: Journal of Colloid and Interface Science
Haicui Lu, Jizhang Chen, Qinghua Tian
Wearable electronics are developing rapidly in recent years. In this work, we develop a cost-effective, facile, and scalable approach to transform insulating cotton textile to highly conductive Ni-coated cotton textile (NCT). In order to verify the feasibility of NCT as a flexible current collector for wearable supercapacitors, we electrodeposit low-crystalline Ni-Al layered double hydroxide (LDH) nanoparticles onto the NCT. The obtained NCT@NiAl-LDH shows high specific capacitance (935.2 mF cm(-2)), superior rate capability, and good cyclability...
November 16, 2017: Journal of Colloid and Interface Science
Jean J Hwang, Carlos Soto, Daniel Lafaurie, Moses Stephen, David M Sarno
HYPOTHESIS: Porous spheres of the conducting polymer polyaniline (PANI) and its derivatives are promising materials for use as functional encapsulants for payload delivery and catalyst supports. Stable water-in-oil-in water (W/O/W) double emulsions can be used to obtain this morphology, but typically require multiple surfactants and stabilizers. A single surfactant system that uses a small amphiphilic molecule is desirable, as it can simplify the method, improve its efficiency, and reduce its cost...
November 10, 2017: Journal of Colloid and Interface Science
H McCarthy, S O'Donnell, R W Costello, H Humphreys
Little data is available on the resource utilisation of patients admitted with Community-Acquired Pneumonia (CAP) in Ireland. A retrospective review of 50 randomly-selected patients admitted to Beaumont Hospital with CAP was undertaken. The mean length of stay of patients with CAP was 12 days (+/- 16 days). All patients were emergency admissions, all had a chest x-ray, a C-reactive protein blood test, and occupied a public bed at some point during admission. Common antimicrobial therapies were intravenous (IV) amoxicillin/clavulanic acid and oral clarithromycin; 60% received physiotherapy...
August 12, 2017: Irish Medical Journal
Gregory J Hanson, Bijan J Borah, James P Moriarty, Jeanine E Ransom, James M Naessens, Paul Y Takahashi
BACKGROUND/OBJECTIVES: Facing penalties for preventable 30-day hospital readmissions, many provider groups have implemented programs to remedy this problem, but the cost efficacy and value of such programs are not well delineated. The objective was to compare total cost of care over 30 days of individuals enrolled in the Mayo Clinic Care Transitions (MCCT) program and individuals not enrolled. DESIGN: Retrospective cohort study using secondary data analysis of a previously published cohort study...
November 23, 2017: Journal of the American Geriatrics Society
Yali Dong, Ling Wang, Feng Wang, Nan Li, Yi Jin, Jinchao Zhang, Xinjian Yang
Hydrogen sulfide (H2S) is one of the most crucial gas signaling agents that mediate many physiological and pathological processes. However, rapid high-efficiency detection and imaging of H2S in living cells is very challenging. Herein we reported a simple fluorescent nanoprobe using FAM-DNA/AgNP nanocomposites for fast and sensitive H2S detection based on surface silver displacement. In contrast to the conventional principles for fluorescence turn-on analyte detection, the present work demonstrated a sensitive and selective AgNP based optosensor for the assay of H2S...
November 23, 2017: Analyst
Jing Liu, Jingyi Zeng, Yaping Tian, Nandi Zhou
A lateral flow strip biosensor for fast, sensitive, low-cost and on-site detection of kanamycin was developed by using kanamycin-specific aptamer-modified gold nanoparticles (AuNPs-apt) as a probe and oligonucleotide DNA1-modified silver nanoparticles (AgNPs-DNA1) as a signal amplification element. Through the complementary sequences of DNA1 and the aptamer, the AgNP-DNA1-apt-AuNPs complex can be formed and further captured on the test zone of the strip, where a capture probe DNA2 complementary to the 3'-terminal of DNA1 was immobilized...
November 23, 2017: Analyst
Maria Eugenia Roca Jalil, Miria Baschini, Karim Sapag
Emerging contaminants in the environment have caused enormous concern in the last few decades, and among them, antibiotics have received special attention. On the other hand, adsorption has shown to be a useful, low-cost, and eco-friendly method for the removal of this type of contaminants from water. This work is focused on the study of ciprofloxacin (CPX) removal from water by adsorption on pillared clays (PILC) under basic pH conditions, where CPX is in its anionic form (CPX(-)). Four different materials were synthetized, characterized, and studied as adsorbents of CPX (Al-, Fe-, Si-, and Zr-PILC)...
November 23, 2017: Materials
Wei He, Sebastien Pillement, Du Xu
Clustering is an efficient approach in a wireless sensor network (WSN) to reduce the energy consumption of nodes and to extend the lifetime of the network. Unfortunately, this approach requires that all cluster heads (CHs) transmit their data to the base station (BS), which gives rise to the long distance communications problem, and in multi-hop routing, the CHs near the BS have to forward data from other nodes that lead those CHs to die prematurely, creating the hot zones problem. Unequal clustering has been proposed to solve these problems...
November 23, 2017: Sensors
James Mino, Bernadette Quémerais
The objective of this project was to create similar exposure groups (SEGs) for occupational monitoring in a structural steel fabrication facility. Qualitative SEG formation involved worksite observation, interviews, and audits of materials and procedures. These were supplemented with preliminary task-based shop survey data collected using a condensation particle counter. A total of six SEGs were formed, with recommendations for occupational exposure sampling for five groups, as well as ambient sampling recommendations to address areas on the operational floor found to have higher particle concentrations...
November 23, 2017: Toxics
Tianjie Hong, Jun Mao, Feifei Tao, Mingxuan Lan
Using ilmenite as a raw material, iron was converted into Fe₃O₄ magnetic fluid, which further was combined with titanium filtrate by a solvothermal method. Finally Fe₃O₄/TiO₂ nanocomposites with the uniform size of 100-200 nm were prepared. This approach uses rich, inexpensive ilmenite as a titanium and iron source, which effectively reduces the production cost. The crystal structure, chemical properties and morphologies of the products were characterized by SEM, TEM, XRD, FTIR, BET, UV-Vis, XPS and VSM...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Thijs Vandenryt, Bart van Grinsven, Kasper Eersels, Peter Cornelis, Safira Kholwadia, Thomas J Cleij, Ronald Thoelen, Ward De Ceuninck, Marloes Peeters, Patrick Wagner
Serotonin is an important neurotransmitter that plays a major role in the pathogenesis of a variety of conditions, including psychiatric disorders. The detection of serotonin typically relies on high-performance liquid chromatography (HPLC), an expensive technique that requires sophisticated equipment and trained personnel, and is not suitable for point-of-care applications. In this contribution, we introduce a novel sensor platform that can measure spiked neurotransmitter concentrations in whole blood samples in a fast and low-cost manner by combining synthetic receptors with a thermal readout technique-the heat-transfer method...
November 23, 2017: Sensors
Yicheng Fu, Xia Du, Benqing Ruan, Laisheng Liu, Jian Zhang
The paper aims at providing a framework to calculate the agro-eco-compensation standard based on the systems agro-ecological concept of embodied energy as emergy. We have proposed a calculation system of eco-compensation standard for sustainable agricultural development based on the convertibility between emergy and price. According to our calculation, the total energy of agricultural production in Yongding River Basin was 3.45 E + 16 Sej/ha (the unit emergy value, expressed in solar emergy joules per unit) in terms of the renewable resources, nonrenewable resources, material inputs, and service costs...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
T Ennil Bektaş
A coagulation-flocculation process was applied to wastewater of paint and construction chemicals producing factory in Turkey. Ferric chloride was used as coagulant and several natural based materials, namely limestone, pumice, sepiolite, bentonite and mussel shell were used as flocculant aids. The effects of dosage of flocculant aids on the pH, color and electrical conductivity of wastewater were studied. The experimental results showed that the treatment with all substances was very effective. The pHs of treated wastewater were obtained in the range of 5-7 without needing pH adjustment process...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Daniel Jung, Laetitia Hatrait, Julien Gouello, Arnaud Ponthieux, Vincent Parez, Christophe Renner
Hydrogen sulfide (H2S) represents one of the main odorant gases emitted from sewer networks. A mathematical model can be a fast and low-cost tool for estimating its emission. This study investigates two approaches to modeling H2S gas transfer at a waterfall in a discharge manhole. The first approach is based on an adaptation of oxygen models for H2S emission at a waterfall and the second consists of a new model. An experimental set-up and a statistical data analysis allowed the main factors affecting H2S emission to be studied...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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