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https://www.readbyqxmd.com/read/28938728/modeling-of-live-birth-rates-and-cost-effectiveness-of-oocyte-cryopreservation-for-cancer-patients-prior-to-high-and-low-risk-gonadotoxic-chemotherapy
#1
B Lyttle Schumacher, N Grover, T Mesen, A Steiner, J Mersereau
STUDY QUESTION: What is the live-birth rate (LBR) and cost-effectiveness of fertility preservation with oocyte cryopreservation (FP-OC) compared to expectant management in cancer patients age 25-40 based on estimated gonadotoxicity of treatments 5 years after cancer diagnosis? SUMMARY ANSWER: Oocyte cryopreservation prior to cancer treatment is more costly, yet more effective (producing more live births), than not undergoing oocyte cryopreservation but it is most beneficial for patients undergoing high-risk chemotherapy (HRC)...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938720/deep-whole-genome-sequencing-of-90-han-chinese-genomes
#2
Tianming Lan, Haoxiang Lin, Wenjuan Zhu, Tellier Christian Asker Melchior Laurent, Mengcheng Yang, Xin Liu, Jun Wang, Jian Wang, Huanming Yang, Xun Xu, Xiaosen Guo
Next-generation sequencing provides a high-resolution insight into human genetic information. However, the focus of previous studies has primarily been on low-coverage data due to the high cost of sequencing. Although the 1000 Genomes Project and the Haplotype Reference Consortium have both provided powerful reference panels for imputation, low-frequency and novel variants remain difficult to discover and call with accuracy on the basis of low-coverage data. Deep sequencing provides an optimal solution for the problem of these low-frequency and novel variants...
September 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28938479/pulmonary-function-and-sleep-breathing-two-new-targets-for-type-2-diabetes-care
#3
Albert Lecube, Rafael Simó, Maria Pallayova, Naresh M Punjabi, Carolina López-Cano, Cecilia Turino, Cristina Hernández, Ferran Barbé
Population based studies showing the negative impact of type 2 diabetes (T2D) on lung function are overviewed. Among the well-recognized pathophysiological mechanisms, the metabolic pathways related to insulin resistance, low-grade chronic inflammation, leptin resistance, microvascular damage, and autonomic neuropathy are emphasized. Histopathological changes are exposed, and findings reported from experimental models are clearly differentiated from those described in humans. The accelerated decline in pulmonary function that appears in patients with cystic fibrosis with related abnormalities of glucose tolerance and diabetes is considered as an example to further investigate the relationship between T2D and the lung...
September 4, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28938475/modeling-the-sex-differences-and-inter-individual-variability-in-the-activity-of-the-hypothalamic-pituitary-adrenal-axis
#4
Rohit T Rao, Ioannis P Androulakis
Significant sex differences exist in the activity of the hypothalamic-pituitary-adrenal (HPA) axis. These differences are thought to contribute to the disparity in the prevalence of various autoimmune and infectious diseases between males and females. We use a mathematical model of the HPA axis to evaluate the hypothesis that differential sensitivity and negative feedback of the HPA axis network are causal factors for the observed sex differences in its activity. In doing so, we implicitly account for the differential influence of gonadal hormones on the HPA axis...
August 31, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938418/androgens-support-male-acrobatic-courtship-behavior-by-enhancing-muscle-speed-and-easing-the-severity-of-its-trade-off-with-force
#5
Matthew J Fuxjager, Meredith C Miles, Franz Goller, John Petersen, Julia Yancey
Steroid hormone action in the brain regulates many animals' elaborate social displays used for courtship and competition, but it is increasingly recognized that the periphery may also be a site for potent steroidal modulation of complex behavior. However, the mechanisms of such "bottom up" regulation of behavioral outflow are largely unclear. To study this problem, we examine how androgenic sex hormones act through the skeletal muscular system to mediate elaborate courtship acrobatics in a tropical bird called the golden-collared manakin...
August 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938264/2016-neonatal-nurse-practitioner-workforce-survey-report-of-findings
#6
Suzanne Staebler, Robin Bissinger
The National Association of Neonatal Nurse Practitioners (NANNP) conducted its second workforce survey of certified neonatal nurse practitioners in the fall of 2016. National Association of Neonatal Nurse Practitioners partnered with the National Certification Corporation and the American Association of Nurse Practitioners to conduct this electronic survey, containing 69 questions and focusing on practice sites and total compensation packages (including benefits) and workforce deficits.Findings indicate a rising neonatal nurse practitioners (NNPs) position vacancy rate across the country...
October 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28938248/a-youth-compendium-of-physical-activities-activity-codes-and-metabolic-intensities
#7
Nancy F Butte, Kathleen B Watson, Kate Ridley, Issa F Zakeri, Robert G McMurray, Karin A Pfeiffer, Scott E Crouter, Stephen D Herrmann, David R Bassett, Alexander Long, Zekarias Berhane, Stewart G Trost, Barbara E Ainsworth, David Berrigan, Janet E Fulton
PURPOSE: A Youth Compendium of Physical Activities (Youth Compendium) was developed to estimate the energy costs of physical activities using data on youth only. METHODS: Based on a literature search and pooled data of energy expenditure measurements in youth, the energy costs of 196 activities were compiled in 16 activity categories to form a Youth Compendium of Physical Activities. To estimate the intensity of each activity, measured oxygen consumption (V[Combining Dot Above]O2) was divided by basal metabolic rate (Schofield age-, sex- and mass-specific equations) to produce a youth MET (METy)...
September 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28938242/clinical-data-warehouse-an-effective-tool-to-create-intelligence-in-disease-management
#8
Mahtab Karami, Azin Rahimi
Clinical business intelligence tools such as clinical data warehouse enable health care organizations to objectively assess the disease management programs that affect the quality of patients' life and well-being in public. The purpose of these programs is to reduce disease occurrence, improve patient care, and decrease health care costs. Therefore, applying clinical data warehouse can be effective in generating useful information about aspects of patient care to facilitate budgeting, planning, research, process improvement, external reporting, benchmarking, and trend analysis, as well as to enable the decisions needed to prevent the progression or appearance of the illness aligning with maintaining the health of the population...
September 21, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28938216/efficient-removal-of-priority-hazardous-priority-and-emerging-pollutants-with-prunus-armeniaca-functionalized-biochar-from-aqueous-wastes-experimental-optimization-and-modeling
#9
Maja Turk Sekulić, Sabolč Pap, Zoran Stojanović, Nikola Bošković, Jelena Radonić, Tatjana Šolević Knudsen
This paper investigates the ability of the phosphoric acid functionalized Prunus armeniaca stones biochar (AsPhA) prepared by thermochemical activation to remove lead (Pb(2+)), cadmium (Cd(2+)), nickel (Ni(2+)), naproxen and chlorophenols from aqueous wastes. The engineered biochar was characterized using the Scanning Electron Microscopy, Energy-dispersive X-ray Spectroscopy, Fourier Transform Infrared Spectroscopy and Brunauer, Emmett and Teller technique. The batch studies were performed by varying the initial pH of the solution (2-9), adsorbent dosage (0...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938066/systematic-optimization-of-battery-materials-key-parameter-optimization-for-the-scalable-synthesis-of-uniform-high-energy-and-high-stability-lini0-6mn0-2co0-2o2-cathode-material-for-lithium-ion-batteries
#10
Dong Ren, Yun Shen, Yao Yang, Luxi Shen, Barnaby D A Levin, Yingchao Yu, David A Muller, Héctor D Abruña
Ni-rich LiNixMnyCo1-x-yO2 (x>0.5) (NMC) materials have attracted a great deal of interest as promising cathode candidates for Li-ion batteries (LIBs) due to their low cost and high energy density. However, several issues, including sensitivity to moisture, difficulty in reproducibly preparing well-controlled morphology particles and, poor cyclability, have hindered their large scale deployment; especially for electric vehicle (EV) applications. In this work, we have developed a uniform, highly stable, high-energy density, Ni-rich LiNi0...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28938046/the-value-that-infectious-diseases-physicians-bring-to-the-healthcare-system
#11
Daniel P McQuillen, Ann T MacIntyre
While a career in infectious diseases (ID) has always been challenging and exciting, recognition of the value that ID physicians provide to the healthcare system as a whole, over and above the value they provide to individual patients, has been poor in this system. In response to this disparity, the Infectious Diseases Society of America Clinical Affairs Committee has long endeavored to quantify the value of ID physicians to the system, which is challenging in part because of the many avenues through which they influence healthcare...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28938002/regional-endothermy-as-a-trigger-for-gigantism-in-some-extinct-macropredatory-sharks
#12
Humberto G Ferrón
Otodontids include some of the largest macropredatory sharks that ever lived, the most extreme case being Otodus (Megaselachus) megalodon. The reasons underlying their gigantism, distribution patterns and extinction have been classically linked with climatic factors and the evolution, radiation and migrations of cetaceans during the Paleogene. However, most of these previous proposals are based on the idea of otodontids as ectothermic sharks regardless of the ecological, energetic and body size constraints that this implies...
2017: PloS One
https://www.readbyqxmd.com/read/28937986/household-costs-of-hospitalized-dengue-illness-in-semi-rural-thailand
#13
Yesim Tozan, Pitcha Ratanawong, Maquines Odhiambo Sewe, Annelies Wilder-Smith, Pattamaporn Kittayapong
BACKGROUND: Dengue-related illness is a leading cause of hospitalization and death in Thailand and other Southeast Asian countries, imposing a major economic burden on households, health systems, and governments. This study aims to assess the economic impact of hospitalized dengue cases on households in Chachoengsao province in eastern Thailand. METHODS: We conducted a prospective cost-of-illness study of hospitalized pediatric and adult dengue patients at three public hospitals...
September 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28937947/wastewater-treatment-by-means-of-thermophilic-aerobic-membrane-reactors-respirometric-tests-and-numerical-models-for-determination-of-stoichiometric-kinetic-parameters
#14
Maria Cristina Collivignarelli, Giorgio Bertanza, Alessandro Abbà, Vincenzo Torretta, Ioannis Anastasios Katsoyiannis
The present work considers the pollution abatement of wastewaters, the efficiency of which is depending on stringent verification of the performance of wastewater treatment plants. This is very important especially given that eExisting wastewater/aqueous waste treatment plants often need to be upgraded in order to improve their performance. The satisfactory operation of biological treatment plants requires appropriate monitoring, and respirometric techniques are needed to determine the kinetic parameters that regulate biological processes...
September 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28937865/recall-of-the-real-cost-anti-smoking-campaign-is-specifically-associated-with-endorsement-of-campaign-targeted-beliefs
#15
Elissa C Kranzler, Laura A Gibson, Robert C Hornik
Though previous research suggests the FDA's "The Real Cost" anti-smoking campaign has reduced smoking initiation, the theorized pathway of effects (through targeted beliefs) has not been evaluated. This study assesses the relationship between recall of campaign television advertisements and ad-specific anti-smoking beliefs. Respondents in a nationally representative survey of nonsmoking youths age 13-17 (n = 4,831) reported exposure to four The Real Cost advertisements and a fake ad, smoking-relevant beliefs, and nonsmoking intentions...
September 22, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28937858/our-mother-s-mitochondria-and-our-mind
#16
Peter Kramer, Paola Bressan
Most of the energy we get to spend is furnished by mitochondria, minuscule living structures sitting inside our cells or dispatched back and forth within them to where they are needed. Mitochondria produce energy by burning down what remains of our meal after we have digested it, but at the cost of constantly corroding themselves and us. Here we review how our mitochondria evolved from invading bacteria and have retained a small amount of independence from us; how we inherit them only from our mother; and how they are heavily implicated in learning, memory, cognition, and virtually every mental or neurological affliction...
September 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28937855/eggshell-biliverdin-and-protoporphyrin-pigments-in-a-songbird-are-they-derived-from-erythrocytes-blood-plasma-or-the-shell-gland
#17
Rita Hargitai, Nóra Boross, Susanne Hámori, Eszter Neuberger, Zoltán Nyiri
Biliverdin and protoporphyrin pigments are deposited into the eggshell when the developing egg is in the shell gland. However, the site of synthesis of eggshell pigments is still uncertain, although it may influence the possible costs and potential functions of eggshell coloration in avian species. Eggshell pigments may be derived from red blood cells or be produced in other organs and then transferred to the shell gland, or they may be synthesized de novo in the shell gland. We studied in the canary (Serinus canaria) whether eggshell blue-green and brown pigmentations are associated with experimentally elevated anemia, female hematocrit level, immature erythrocyte percentage, and feces and plasma pigment levels during egg laying to find out the possible origin of eggshell pigments...
November 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28937819/should-i-change-or-should-i-go-phenotypic-plasticity-and-matching-habitat-choice-in-the-adaptation-to-environmental-heterogeneity
#18
Pim Edelaar, Roger Jovani, Ivan Gomez-Mestre
It can be challenging for organisms to achieve a good match between their phenotypic characteristics and environmental requirements that vary in space and time. The evolution of adaptive phenotypes can result from genetic differentiation at the population level. Individuals, however, could also change their phenotype (adaptive plasticity) or select an environment because it matches with their phenotype (matching habitat choice). It is poorly known under which conditions these different solutions to environmental heterogeneity evolve and whether they operate together...
October 2017: American Naturalist
https://www.readbyqxmd.com/read/28937815/differential-allocation-revisited-when-should-mate-quality-affect-parental-investment
#19
Thomas R Haaland, Jonathan Wright, Bram Kuijper, Irja I Ratikainen
Differential allocation (DA) is the adaptive adjustment of reproductive investment (up or down) according to partner quality. A lack of theoretical treatments has led to some confusion in the interpretation of DA in the empirical literature. We present a formal framework for DA that highlights the nature of reproductive benefits versus costs for females mated to males of different quality. Contrary to popular belief, analytical and stochastic dynamic models both show that additive benefits of male quality on offspring fitness have no effect on optimal levels of female investment and thus cannot produce DA...
October 2017: American Naturalist
https://www.readbyqxmd.com/read/28937800/when-is-neuropsychological-testing-medically-necessary-for-children-on-medicaid-in-new-mexico
#20
Noah K Kaufman, Carola Mullins, Andrew S Davis, Silvina Tonarelli, Hugo Sandoval, Luis Ramos-Duran
Healthcare for poor children, also known as Medicaid, is disproportionately relied upon by citizens of poor states such as New Mexico, where (a) there are more unintended pregnancies, (b) domestic violence during and after pregnancies occurs with regularity, (c) youth substance use is much more common, (d) crime rates are some of the worst in the country, (e) many never graduate from high school, and (f) incarceration is often inevitable. Yet, there is a dearth of research into the neuropsychological health of these children...
September 22, 2017: Applied Neuropsychology. Child
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