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https://www.readbyqxmd.com/read/28422487/stepwise-deoxygenation-of-nitrite-as-a-route-to-two-families-of-ruthenium-corroles-group-8-periodic-trends-and-relativistic-effects
#1
Abraham B Alemayehu, Hugo Vazquez-Lima, Kevin J Gagnon, Abhik Ghosh
Given the many applications of ruthenium porphyrins, the rarity of ruthenium corroles and the underdeveloped state of their chemistry are clearly indicative of an area ripe for significant breakthroughs. The tendency of ruthenium corroles to form unreactive metal-metal-bonded dimers has been recognized as a key impediment in this area. Herein, by exposing free-base meso-tris(p-X-phenyl)corroles, H3[TpXPC] (X = CF3, H, Me, and OMe), and [Ru(COD)Cl2]x in refluxing 2-methoxyethanol to nitrite, we have been able to reliably intercept the series Ru[TpXPC](NO) in a matter of seconds to minutes and subsequently Ru(VI)[TpXPC](N), the products of a second deoxygenation, over some 16 h...
April 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28417625/influence-of-sensitization-patterns-on-fractional-exhaled-nitric-oxide-in-asthmatic-children
#2
Miao Qing, Xu Wei, Li Zhen, Guan Hui, Liu Xiao-Ying, Huang Hui-Jie, Wang Yan, Ren Yi-Xin, Liu Yong-Ge, Xiang Li
Fractional exhaled nitric oxide (FeNO) has been suggested as a non-invasive biomarker of airway inflammation, which is increased in atopic subjects. Whether sensitization to particular allergens is a predictive factor for increased FeNO levels is not yet fully understood. We conducted a retrospective cross-sectional study. From October to December in 2015, the medical documents of 127 mild, steroid-naive asthmatic children and 34 healthy age-matched children were enrolled in this study. The results of the FeNO measurements, skin prick test, and the spirometry were collected for analysis...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28407829/-application-of-pulmonary-function-and-fractional-exhaled-nitric-oxide-tests-in-the-standardized-management-of-bronchial-asthma-in-children
#3
Hui-Qin Zhang, Hui-Qin Zhang, Jing-Jing Zhang, Yu-Dong Liu, Yue-Lin Deng, Jian-Feng Luo, Huan-Hong Niu, Xin Sun
OBJECTIVE: To investigate the changes of pulmonary function and fractional exhaled nitric oxide (FeNO) in the standardized treatment of bronchial asthma in children. METHODS: A total of 254 children who were newly diagnosed with acute exacerbation of bronchial asthma were selected as asthma group, and they were divided into two subgroups: asthma with concurrent rhinitis and asthma without concurrent rhinitis. All patients received the standardized management and treatment for one year...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28407269/clinical-functional-and-inflammatory-characteristics-in-patients-with-pauci-granulocytic-stable-asthma-comparison-with-different-sputum-phenotypes
#4
Polyxeni Ntontsi, Stelios Loukides, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Evgenia Papathanassiou, Georgios Hillas, Nikolaos Koulouris, Spyros Papiris, Andriana I Papaioannou
BACKGROUND: According to induced sputum cell count, four different asthma phenotypes have been recognised(eosinophilic, neutrophilic, mixed and pauci-granulocytic). The aim of the present study was to detect functional and inflammatory characteristics of patients with pauci-granulocytic asthma. METHODS: 240 asthmatic patients were categorised in the four phenotypes according to cell counts in induced sputum. All patients underwent pulmonary function tests, and measurement of FeNO...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28405893/airway-and-blood-inflammatory-markers-in-waste-collectors
#5
M Raulf, V van Kampen, H D Neumann, V Liebers, A Deckert, T Brüning, J Bünger, F Hoffmeyer
Waste collectors are exposed to a heterogeneous mixture of bioaerosols able to induce health effects. The study aim was to evaluate inflammatory processes in blood and in the respiratory tract via analysis of atopy and club cell secretory protein 16 (CC16) in serum, exhaled nitric oxide (FeNO), and cellular and soluble mediators in nasal lavage fluid (NALF) and induced sputum (IS). Sixty nine current waste collectors (48% smokers) and 28 former waste collectors (25% smokers) were included in the cross-sectional study...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28403218/association-of-arginase-i-or-nitric-oxide-related-factors-with-job-strain-in-healthy-workers
#6
Keiki Ogino, Tatsuo Ito, Eri Eguchi, Kenjiro Nagaoka
This study evaluated the associations between job strain and arginase I in 378 healthy Japanese factory workers by a cross-sectional study measuring nitric oxide (NO)-related parameters (arginase I, L-arginine, exhaled nitric oxide (FeNO), and NOx), clinical parameters, and job strain using a Japanese version of the Job Content Questionnaire by Karasek. Arginase I and FEV1% were negatively correlated with job strain and positively correlated with job control and social support. FeNO and hs-CRP were negatively correlated with job strain...
2017: PloS One
https://www.readbyqxmd.com/read/28398635/serum-periostin-relates-to-type-2-inflammation-and-lung-function-in-asthma-data-from-the-large-population-based-cohort-swedish-ga-2-len
#7
Anna James, Christer Janson, Andrei Malinovschi, Cecile Holweg, Kjell Alving, Junya Ono, Shoichiro Ohta, Alexandra Ek, Roelinde Middelveld, Barbro Dahlén, Bertil Forsberg, Kenji Izuhara, Sven-Erik Dahlén
BACKGROUND: Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type-2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. AIM: To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics...
April 11, 2017: Allergy
https://www.readbyqxmd.com/read/28393619/fractional-exhaled-nitric-oxide-measurement-in-pulmonary-hypertension-a-follow-up-study
#8
Nilay Orak Akbay, Zuleyha Bingol, Esen Kiyan, Ekrem Bilal Karaayvaz, Ahmet Kaya Bilge, Halim Issever, Gulfer Okumus
Pulmonary hypertension (PH) is a fatal disease although significant improvements in treatment are achieved. Easily implemented and noninvasive prognostic techniques are needed while following-up these patients. The aim was to investigate the role of fractional exhaled nitric oxide (FeNO) in follow-up for patients with PH. In this longitudinal study, patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) who were seen in PH Outpatient Clinic, Istanbul Faculty of Medicine, Istanbul University, were enrolled in the study...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28392751/effects-of-specific-allergen-immunotherapy-on-biological-markers-and-clinical-parameters-in-asthmatic-children-a-controlled-real-life-study
#9
I Djuric-Filipovic, Marco Caminati, D Filipovic, C Salvottini, Z Zivkovic
BACKGROUND: Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sublingual allergen specific immunotherapy). METHODS: 7-18 years old children with allergic asthma and rhinitis were enrolled and addressed to the active (AIT plus pharmacological treatment) or control (standard pharmacological treatment only) group...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28392708/lung-sound-analysis-helps-localize-airway-inflammation-in-patients-with-bronchial-asthma
#10
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Hiroshi Nakano, Akiko Ishimatsu, Reiko Kishikawa, Tomoaki Iwanaga
PURPOSE: Airway inflammation can be detected by lung sound analysis (LSA) at a single point in the posterior lower lung field. We performed LSA at 7 points to examine whether the technique could identify the location of airway inflammation in patients with asthma. PATIENTS AND METHODS: Breath sounds were recorded at 7 points on the body surface of 22 asthmatic subjects. Inspiration sound pressure level (ISPL), expiration sound pressure level (ESPL), and the expiration-to-inspiration sound pressure ratio (E/I) were calculated in 6 frequency bands...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28390585/biomarkers-of-oxidative-stress-and-antioxidants-in-severe-asthma-a-prospective-case-control-study
#11
Abigail Bishopp, Ramamurthy Sathyamurthy, Sarah Manney, Craig Webbster, Mamidipudi Thirumala Krishna, Adel H Mansur
BACKGROUND: Bronchial airway inflammation is the hallmark of asthma, which may be driven by an imbalance between oxidative stress and antioxidant defenses. Antioxidants deficiency may play a role, but this has remained unconfirmed. OBJECTIVE: To evaluate the oxidative stress burden and antioxidants defenses in patients with increasing asthma severity. METHODS: This prospective case-control study compared fractional exhaled nitric oxide (FeNO), exhaled breath condensate nitrite/nitrate (EBC-NOx), spirometry, and serum vitamins and trace elements among patients with and without asthma...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28390083/high-fractional-exhaled-nitric-oxide-and-sputum-eosinophils-are-associated-with-an-increased-risk-of-future-virus-induced-exacerbations-ndash-a-prospective-cohort-study
#12
Asger Bjerregaard, Ingrid A Laing, Vibeke Backer, Asger Sverrild, Siew-Kim Khoo, Glenys Chidlow, Chisha Sikazwe, David W Smith, Peter Le Souëf, Celeste Porsbjerg
BACKGROUND: The major trigger of asthma exacerbations is infection with a respiratory virus, most commonly rhinovirus. Type 2 inflammation is known to be associated with an increased risk of exacerbations in general. Whether type 2 inflammation at baseline increases the risk of future virus-induced exacerbations is unknown. OBJECTIVE: To assess whether type 2 inflammation is associated with an increased risk of virus-induced exacerbations of asthma. METHODS: Stable asthmatics had spirometry, skin prick test, measurement of FeNO and sputum induced for differential cell counts...
April 8, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28377348/-comparison-of-functional-parameters-of-small-airways-between-patients-with-typical-asthma-and-cough-variant-asthma
#13
Shu-Yu Chen, Ze-Kui Fang, Si Fang, Qi-Xiao Shen, Xi He, Cui-Lan Wang, Hua-Peng Yu
OBJECTIVE: To compare the functional parameters of the small airways and clinical characteristics between patients with typical asthma (TA) and cough-variant asthma (CVA). METHODS: Forty-three newly diagnosed asthmatic patients were enrolled, including 15 with TA and positive bronchial provocation test [TA BPT(+)], 12 with TA and positive bronchial dilation test [TA BDT(+)] and 16 with CVA, and 27 healthy subjects served as the control group. All the subjects were required to complete data acquisition, asthma control test, asthma control test scale, fractional exhaled nitric oxide, airway resistance and pulmonary function tests, BPT or BDT...
March 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28376119/obesity-disproportionately-impacts-lung-volumes-airflow-and-exhaled-nitric-oxide-in-children
#14
Tsung-Chieh Yao, Hui-Ju Tsai, Su-Wei Chang, Ren-Hua Chung, Jing-Ya Hsu, Ming-Han Tsai, Sui-Ling Liao, Man-Chin Hua, Shen-Hao Lai, Li-Chen Chen, Kuo-Wei Yeh, Yu-Lun Tseng, Wan-Chen Lin, Su-Ching Chang, Jing-Long Huang
BACKGROUND: The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy...
2017: PloS One
https://www.readbyqxmd.com/read/28366480/biologic-and-new-therapies-in-asthma
#15
REVIEW
Farnaz Tabatabaian, Dennis K Ledford, Thomas B Casale
Several biologics are currently FDA approved for asthma that target Th2 high patients. Unfortunately, 50% of patients with severe asthma do not fit this phenotype of disease and have fewer effective therapeutic options. In the clinical setting, total IgE, FeNO and peripheral blood eosinophils are important tools in defining Th2 high patients with asthma. However, precise biomarkers to predict better response to one specific Th2 high asthma therapy versus another is lacking. It is important to recognize that none of the current medications targeting the Th2 pathway induces persistent immunomodulation or remission...
May 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28360460/fractional-exhaled-nitric-oxide-is-a-useful-adjunctive-modality-for-monitoring-bronchial-asthma
#16
Venkatnarayan Kavitha, Anant Mohan, Karan Madan, Vijay Hadda, G C Khilnani, Randeep Guleria
BACKGROUND AND OBJECTIVE: To evaluate the utility of fractional exhaled nitric oxide (FeNO) in monitoring asthma control. MATERIALS AND METHODS: Steroid naïve nonsmoking asthmatics were recruited and followed for 6-8 weeks on standard treatment. Serial measurements of FeNO, peak expiratory flow rate (PEFR) variability, forced expiratory volume in 1 s (FEV1), bronchodilator reversibility (BDR), and asthma control test (ACT) score were measured at baseline and after 6-8 weeks of treatment...
March 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28357800/comparison-of-normal-and-dusty-day-impacts-on-fractional-exhaled-nitric-oxide-and-lung-function-in-healthy-children-in-ahvaz-iran
#17
Abdolkazem Neisi, Mehdi Vosoughi, Esmaeil Idani, Gholamreza Goudarzi, Afshin Takdastan, Ali Akbar Babaei, Kambiz Ahmadi Ankali, Sadegh Hazrati, Maryam Haddadzadeh Shoshtari, Iman Mirr, Heidar Maleki
Children are the vulnerable group at risk of adverse health effects related to air pollution due to dust storm in Ahvaz. The purpose of this study was to compare the values of fractional exhaled nitric oxide (FENO) and lung functions as parameters of adverse health effects of particulate matter (PM) in dusty and normal (non-dusty) days in elementary schoolchildren. The study was conducted among elementary school students in Ahvaz. The healthy elementary schoolchildren (N = 105) were selected from different districts for FENO and lung function sampling during the dusty and normal days...
March 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28356764/study-of-nasal-exhaled-nitric-oxide-levels-in-diagnosis-of-allergic-rhinitis-in-subjects-with-and-without-asthma
#18
Sy Duong-Quy, Thuc Vu-Minh, Thong Hua-Huy, Tram Tang-Thi-Thao, Khiet Le-Quang, Dinh Tran-Thanh, Nhu Doan-Thi-Quynh, Nhat-Nam Le-Dong, Timothy J Craig, Anh-Tuan Dinh-Xuan
BACKGROUND: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established. OBJECTIVE: To study the cutoff of nasal FENO in the diagnosis of subjects with AR and AR-asthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28333970/-epicatechin-3-o-%C3%AE-d-allopyranoside-from-davallia-formosana-prevents-diabetes-and-dyslipidemia-in-streptozotocin-induced-diabetic-mice
#19
Cheng-Hsiu Lin, Jin-Bin Wu, Jia-Ying Jian, Chun-Ching Shih
The objective of this study was to evaluate the effects and molecular mechanism of (-)-epicatechin-3-O-β-D-allopyranoside from Davallia formosana (BB) (also known as Gu-Sui-Bu) on type 1 diabetes mellitus and dyslipidemia in streptozotocin (STZ)-induced diabetic mice. This plant was demonstrated to display antioxidant activities and possess polyphenol contents. Diabetic mice were randomly divided into six groups and were given daily oral gavage doses of either BB (at three dosage levels), metformin (Metf) (at 0...
2017: PloS One
https://www.readbyqxmd.com/read/28328850/measurement-of-exhaled-nitric-oxide-concentration-in-patients-with-obstructive-sleep-apnea-a-meta-analysis
#20
Dongmei Zhang, Jinmei Luo, Yixian Qiao, Yi Xiao, Rong Huang, Xu Zhong
BACKGROUND: Exhaled nitric oxide (eNO) has been proposed as a noninvasive measure of airway inflammation. However, its value in patients with obstructive sleep apnea (OSA) is still controversial. The authors aim to assess the difference in eNO levels between patients with OSA and controls by a meta-analysis. METHODS: A systematic search was performed in the PubMed, EMBASE, the Cochrane Library, and MEDLINE databases to collect relevant studies published from 1996 to 2016...
March 2017: Medicine (Baltimore)
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