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https://www.readbyqxmd.com/read/29328030/modern-approaches-to-fractional-exhaled-nitric-oxide-as-a-useful-biomarker-for-allergic-asthma-phenotyping-and-management
#1
N Mgaloblishvili, M Gotua
Asthma is a pathologically heterogeneous disease, consisting of several phenotypes. Different types of airway inflammation are the cornerstone feature of this condition. Fraction of nitric oxide in exhaled air (FENO) has been proposed as a noninvasive, specific biomarker for eosinophilic airway inflammation and has been shown to be elevated in patients with allergic asthma phenotype. More recent studies indicate that FeNO identifies T-helper cell type 2 (Th2)-mediated airway inflammation with a high predictive value for identifying inhaled corticosteroid (ICS) responsive airway inflammation...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29324380/estimated-individual-inhaled-dose-of-fine-particles-and-indicators-of-lung-function-a-pilot-study-among-chinese-young-adults
#2
Tian Xu, Jian Hou, Juan Cheng, Runbo Zhang, Wenjun Yin, Cheng Huang, Xiaochuan Zhu, Weihong Chen, Jing Yuan
Fine particle (PM2.5)-related lung damage has been reported in most studies regarding environmental or personal PM2.5 concentrations. To assess effects of personal PM2.5 exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM2.5 based on their microenvironmetal PM2.5 concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1β on the final day...
January 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29318959/novel-biological-therapies-in-severe-asthma-targeting-the-right-trait
#3
Gilda Varricchi, Giancarlo Marone, Giuseppe Spadaro, Michele Russo, Francescopaolo Granata, Arturo Genovese, Gianni Marone
Asthma is a heterogeneous disease characterized by chronic airway inflammation that results in a wide spectrum of clinical manifestations. Patients with severe asthma represent a substantial share of consumption of healthcare resources and hospitalization. Moreover, these patients are at risk of increased morbidity and mortality. Recently, several phenotypes and endotypes of asthma have been identified. The identification of specific subtypes of asthma is fundamental for optimizing the clinical benefit of novel treatments...
January 9, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29304558/reduction-of-feno-by-tap-water-and-carbonated-water-mouthwashes-magnitude-and-time-course
#4
Paul Guenther Lassmann-Klee, Tuula Lindholm, Markus Metsälä, Lauri Halonen, Anssi Raimo Antero Sovijärvi, Päivi Piirilä
Fractional exhaled nitric oxide (FENO) assesses eosinophilic inflammation of the airways, but FENO values are also influenced by oral nitric oxide (NO). The aim of this pilot study was to measure FENO and compare the effect of two different mouthwashes on FENO and analyse the duration of the effect. FENO was measured in 12 randomized volunteers (healthy or asthmatic subjects) with a NIOX VERO® analyser at an expiratory flow rate of 50 mL/s. After a baseline measurement, a mouthwash was performed either with tap water or carbonated water and was measured during 20 min in 2 min intervals...
January 5, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29301349/associations-of-serum-25-oh-d-concentrations-with-lung-function-airway-inflammation-and-common-cold-in-the-general-population
#5
Rachida Rafiq, Willemien Thijs, Robert Prein, Renate T de Jongh, Christian Taube, Pieter S Hiemstra, Renée de Mutsert, Martin den Heijer
Vitamin D is hypothesized to have a beneficial effect on lung function and respiratory infections. The aim of this study was to assess the relationship of serum 25-hydroxyvitamin D (25(OH)D) concentrations with lung function, airway inflammation and common colds. We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort study. We included participants with measurements of serum 25(OH)D, Forced Expiratory Volume in 1 s (FEV₁), Forced Vital Capacity (FVC), Fractional Exhaled Nitric Oxide (FeNO), and data on self-reported common colds (n = 6138)...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29296089/elevated-fractional-exhaled-nitric-oxide-and-blood-eosinophil-counts-are-associated-with-a-17q21-asthma-risk-allele-in-adult-subjects
#6
Elizabeth A Schwantes, Michael D Evans, Alex Cuskey, Alex Burford, Judith A Smith, Robert F Lemanske, Nizar N Jarjour, Sameer K Mathur
Background and objectives: Genome-wide association studies identified single-nucleotide polymorphisms (SNPs) at the 17q21 locus conferring increased risk for childhood-onset asthma. Little is known about how these SNPs impact adult asthma patients. We sought to examine an adult population for associations between rs7216389 (17q21-associated SNP) and features of asthma including fractional exhaled nitric oxide (FeNO), eosinophil counts, and age of asthma onset. Methods: Subjects were genotyped at SNP rs7216389...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29283360/the-influence-of-dilution-on-the-offline-measurement-of-exhaled-nitric-oxide
#7
Victoria MacBean, Dharmika Pooranampillai, Catherine Howard, Alan Charles Lunt, Anne Greenough
Measurement of fractional exhaled nitric oxide (FeNO) is used to determine the presence and severity of eosinophilic airway inflammation in asthma and other wheezing illnesses. The gold standard of online measurement during a single prolonged exhalation is not suitable for use in young children. The international guidelines for offline measurements recommend collection of exhaled gas in an appropriate reservoir for later analysis in young children. The apparatus required for gas collection, however, creates dead space within the system, which may result in sample dilution and hence inaccuracy...
December 28, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29281195/physiological-responses-to-prolonged-saturation-diving-a-field-based-pilot-study
#8
Sanjoy Deb, Katherine Burgess, Paul Swinton, Eimear Dolan
This study aimed to assess the effect of extreme environmental exposure during an operational saturation dive on airway inflammation (exhaled nitric oxide (FeNo)), components of fitness (flexibility and aerobic capacity) and blood hematological variables. Six saturation divers, who undertook a 26±0.5 day operational saturation dive were recruited to take part in this study. Participants completed a field-based repeated measure test battery on three occasions (pre-dive, post-dive and 24 hours after saturation dive)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29279057/characterizing-patients-with-asthma-who-received-global-initiative-for-asthma-steps-4-5-therapy-and-managed-in-a-specialty-care-setting
#9
Brian Stone, Jill R Davis, Frank Trudo, Bradd Schiffman, Carlos Alzola, David Brown, Kathleen M Fox
BACKGROUND: Severe asthma is recognized in the European Respiratory Society/American Thoracic Society guidelines as a major unmet need in the management of asthma. OBJECTIVE: The study objective was to describe the clinical burden of Global Initiative for Asthma (GINA) steps 4-5 asthma for patients treated by specialists in the U.S. community setting. METHODS: Patients, ages ≥12 years, with asthma who received GINA step 4 or 5 treatment and were treated at a large U...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29278953/reduction-in-exhaled-nitric-oxide-tracks-improved-patient-inhaler-compliance-in-difficult-asthma-a-case-study
#10
Eoin Hunt, Deirdre Flynn, Elaine MacHale, Richard W Costello, Desmond M Murphy
INTRODUCTION: Exhaled nitric oxide is believed be a useful surrogate for airways inflammation while non-adherence with therapy is known to be associated with worsening of asthma control. CASE: We present the case of a 49-year-old female with steroid-dependent asthma and an exacerbation rate of >20/year. She was enrolled in a 3-month-long prospective study using a validated diagnostic inhaler device that provided objective evidence of inhaler compliance. Fractional exhaled nitric oxide (FeNO), peak expiratory flow rates, asthma control questionnaires were measured throughout the study period...
December 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29275031/the-diagnostic-accuracy-of-fractional-exhaled-nitric-oxide-testing-in-asthma-a-systematic-review-and-meta-analyses
#11
Zhen Wang, Paolo T Pianosi, Karina A Keogh, Feras Zaiem, Mouaz Alsawas, Fares Alahdab, Jehad Almasri, Khaled Mohammed, Laura Larrea-Mantilla, Wigdan Farah, Lubna Daraz, Patricia Barrionuevo, Allison S Morrow, Larry J Prokop, Mohammad Hassan Murad
OBJECTIVE: To evaluate the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) measurement in individuals with suspected asthma. METHODS: We searched MEDLINE, EMBASE, PsycINFO, Cochrane databases, and SciVerse Scopus from the databases' inception through April 4, 2017, for studies that enrolled patients aged 5 years and older with suspected asthma and evaluated FeNO diagnostic accuracy. Independent reviewers selected studies and extracted data. We used the symmetric hierarchical summary receiver operating characteristic models to estimate test performance...
December 16, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29273668/investigating-fractional-exhaled-nitric-oxide-feno-in-chronic-obstructive-pulmonary-disease-copd-and-asthma-copd-overlap-aco-a-scoping-review-protocol
#12
Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi, Nafiseh Naderi, Miriam Barrecheguren, Abolfazl Dehghan, Jean Bourbeau
INTRODUCTION: During the last decade, many articles have been published, including reviews on fractional exhaled nitric oxide (FeNO) use and utility in clinical practice and for monitoring and identifying eosinophilic airway inflammation, especially in asthma, and evaluating corticosteroid responsiveness. However, the exact role of FeNO in patients with chronic obstructive pulmonary disease (COPD) and its ability to distinguish patients with COPD and those having concomitant asthma, that is, asthma-COPD overlap (ACO) is still unclear and needs to be defined...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29240514/menopausal-asthma-much-ado-about-nothing-an-observational-study
#13
Katarzyna Bialek-Gosk, Marta Maskey-Warzechowska, Rafal Krenke, Marta Dabrowska, Magdalena Paplinska-Goryca, Patrycja Nejman-Gryz, Joanna Domagala-Kulawik, Tadeusz Przybylowski, Ryszarda Chazan
OBJECTIVE: Menopausal asthma is considered a distinct asthma phenotype. Our aim was to identify potential specific features of asthma in postmenopausal women in a cohort of Polish females. METHODS: Asthma severity and control, pulmonary function, exhaled nitric oxide (FENO), peripheral blood and induced sputum (IS) differential cell count were compared in three groups: women with premenopausal asthma (group 1), menopausal women with pre-existing asthma (group 2A) and menopausal women with asthma onset in the perimenopausal or menopausal period (group 2B)...
December 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29231775/the-airway-hyperresponsiveness-to-methacholine-may-be-predicted-by-impulse-oscillometry-and-plethysmography-in-children-with-well-controlled-asthma
#14
Tugba Arıkoglu, Ayyuce Unlu, Didem Derici Yıldırım, Semanur Kuyucu
OBJECTIVE: Airway hyperresponsiveness (AHR) is a hallmark of asthma. Methacholine challenge test which is mostly used to confirm AHR is not routinely available. The aim of this study was to investigate the predictive values of fractional exhaled nitric oxide (FeNO), impulse oscillometry (IOS), and plethysmography for the assessment of AHR in children with well-controlled asthma. METHODS: 60 children with controlled allergic asthma aged 6-18 years participated in the study...
December 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29229474/accuracy-of-a-new-algorithm-to-identify-asthma-copd-overlap-aco-patients-in-a-cohort-of-patients-with-chronic-obstructive-airway-disease
#15
Luis Pérez de Llano, Borja G Cosío, Marc Miravitlles, Vicente Plaza
OBJECTIVES: We aimed to characterize the clinical, functional and inflammatory features of patients diagnosed diagnosed with ACO according to a new algorithm and to compare them with those of other chronic obstructive airway disease (COAD) categories (asthma and COPD). METHODS: ACO was diagnosed in a cohort of COAD patients in those patients with COPD who were either diagnosed with current asthma or showed significant blood eosinophilia (≥300cells/μl) and/or a very positive bronchodilator response (>400ml and >15% in FEV1)...
December 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29223148/exhaled-nitric-oxide-helps-discriminating-asthmatic-children-with-and-without-positive-specific-ige-to-aeroallergens
#16
Li-Ching Fang, Shyh-Dar Shyur, Jun Yang, Jen-Yu Wang, Yu-Hsuan Kao, Chien-Hui Yang, Yu-Ting Yu
BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in asthmatic children with and without positive specific immunoglobulin E (IgE) to at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic rhinitis (AR) aged 5 to 18 years were enrolled into two groups...
December 10, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29212496/pulmonary-function-exhaled-nitric-oxide-and-symptoms-in-asthma-patients-with-obesity-a-cross-sectional-study
#17
Marise J Kasteleyn, Tobias N Bonten, Renée de Mutsert, Willemien Thijs, Pieter S Hiemstra, Saskia le Cessie, Frits R Rosendaal, Niels H Chavannes, Christian Taube
BACKGROUND: Obesity is a risk factor for the development of asthma. In patients with obesity the diagnosis of asthma is often based on symptoms, but without objective measurements. Nevertheless, obesity-associated asthma is recognized as a distinct asthma phenotype. Therefore, this study explores lung function and symptoms in asthma patients with and without obesity. METHODS: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort study with 6671 participants (aged 45-65 years) of whom 472 had asthma...
December 7, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29202821/effects-of-treatment-changes-on-asthma-phenotype-prevalence-and-airway-neutrophil-function
#18
Collin R Brooks, Christine J Van Dalen, Elizabeth Harding, Ian F Hermans, Jeroen Douwes
BACKGROUND: Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthma phenotypes and airway neutrophil function. The purpose of this study was to assess asthma phenotype prevalence/characteristics in a community setting, and, in a nested preliminary study, determine how treatment changes affect phenotype stability and inflammation, with particular focus on airway neutrophils...
December 4, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29186624/local-and-systemic-inflammation-may-mediate-diesel-engine-exhaust-induced-lung-function-impairment-in-a-chinese-occupational-cohort
#19
Haitao Wang, Huawei Duan, Tao Meng, Mo Yang, Lianhua Cui, Ping Bin, Yufei Dai, Yong Niu, Meili Shen, Liping Zhang, Yuxin Zheng, Shuguang Leng
Diesel exhaust (DE) as the major source of vehicle-emitted particle matter in ambient air impairs lung function. The objectives were to assess the contribution of local (e.g., the fraction of exhaled nitric oxide [FeNO] and serum Club cell secretory protein [CC16]) and systemic (e.g., serum C-reaction protein [CRP] and interleukin-6 [IL-6]) inflammation to DE induced lung function impairment using a unique cohort of diesel engine testers (DET, n = 137) and non-DETs (n = 127), made up of current and non-current smokers...
November 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29180311/repeated-fractional-exhaled-nitric-oxide-measurements-is-not-essential-for-asthma-screening
#20
Y Seo Yeon, K Yoon Hee, B Min Kwang, K Hyung Jung, A Chul Min, K Seong Han, L Hye Sun, P Hye Jung
BACKGROUND AND OBJECTIVE: Although older guidelines recommend that fractional exhaled nitric oxide (FeNO) should be checked more than twice during the same session for an asthma diagnosis, recent studies showed the excellent reproducibility of FeNO measurements. Objective: We aimed to determine whether repeated FeNO measurements during the same session are necessary for asthma screening. METHODS: We retrospectively reviewed the electronic medical records of adult outpatient subjects who visited the pulmonary department for an asthma diagnosis and assessed FeNO measurements obtained from June 2016 to July 2017...
November 28, 2017: Journal of Investigational Allergology & Clinical Immunology
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