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https://www.readbyqxmd.com/read/29150070/decreased-expression-of-indolamine-2-3-dioxygenase-in-childhood-allergic-asthma-and-its-inverse-correlation-with-fractional-concentration-of-exhaled-nitric-oxide
#1
Ying Hu, Zhiqiang Chen, Ling Jin, Mei Wang, Wei Liao
BACKGROUND: The tryptophan metabolic pathway mediated by indolamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, plays an important role in controlling the development of allergic inflammation. The fractional concentration of exhaled nitric oxide (FeNO) is closely associated with the allergic state and is extensively used for the clinical evaluation of airway allergic inflammation. Clinical trials have rarely assessed the expression of IDO in childhood allergic asthma and its correlation with FeNO...
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29149738/associations-of-urinary-polycyclic-aromatic-hydrocarbon-metabolites-with-fractional-exhaled-nitric-oxide-and-exhaled-carbon-monoxide-a-cross-sectional-study
#2
Yun Zhou, Yuewei Liu, Huizhen Sun, Jixuan Ma, Lili Xiao, Limin Cao, Wei Li, Bin Wang, Jing Yuan, Weihong Chen
Exposure to Polycyclic aromatic hydrocarbons (PAHs) has been associated with inflammatory responses. Fractional exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) are both important inflammatory mediators especially in airways. However, few studies have investigated associations of PAH exposures with FeNO or eCO. Therefore, we aimed to quantify the associations of urinary PAH metabolites with FeNO and eCO levels, and investigate their potential effect modifiers by linear mixed models among 4133 participants from the Wuhan-Zhuhai cohort in China...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29143374/asthma-and-lung-function-in-adulthood-after-a-viral-wheezing-episode-in-early-childhood
#3
Katri Backman, Hertta Ollikainen, Eija Piippo-Savolainen, Kirsi Nuolivirta, Matti Korppi
BACKGROUND: Viral etiology of infection has a significant role in the long-term outcome of early-childhood wheezing. OBJECTIVE: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV). METHODS: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland)...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29133224/feno-and-exercise-testing-in-children-at-risk-of-asthma
#4
Ann-Marie Malby Schoos, Christina Figgé Christiansen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo Lund Chawes
BACKGROUND: Exercise testing is the gold standard for diagnosing exercise-induced bronchoconstriction in children, but requires considerable cooperation and medical resources. Therefore, fraction of exhaled nitric oxide (FeNO) has been proposed as a tool to predict the need for exercise testing. OBJECTIVE: The objective of this study was to investigate the relationship between FeNO, exercise test results, and a history of respiratory symptoms during exercise in children at risk of asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29128336/the-value-of-fractional-exhaled-nitric-oxide-and-forced-mid-expiratory-flow-as-predictive-markers-of-bronchial-hyperresponsiveness-in-adults-with-chronic-cough
#5
Wuping Bao, Xue Zhang, Chengjian Lv, Luhong Bao, Junfeng Yin, Zhixuan Huang, Bing Wang, Xin Zhou, Min Zhang
BACKGROUND: Bronchial provocation tests are standard for diagnosing the etiology of chronic cough, but they are time consuming and can induce severe bronchospasm. A safer and faster clinical examination to predict bronchial hyperresponsiveness (BHR) is needed. OBJECTIVE: The objective of this study was to investigate whether small-airway function tests can predict BHR in adult patients with chronic cough. METHODS: A retrospective, cross-sectional study of diagnoses made using spirometry and bronchial provocation test results was performed in 290 patients with chronic nonproductive cough...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29119166/pushing-the-photodelivery-of-nitric-oxide-to-the-visible-are-feno-7-complexes-good-candidates
#6
Natalia Levin, Julián Perdoménico, Eckhard Bill, Thomas Weyhermüller, Leonardo D Slep
Photodelivery of NO requires stable compounds which can be made reactive by irradiation with (visible) light. Traditional {MNO}(6) complexes require a substantial ligand design to shift their absorption spectra to the appropriate region of the electromagnetic spectrum. [Fe((CH2Py2)2Me[9]aneN3)(NO)](BF4)2 is a new {FeNO}(7) octahedral coordination compound, which is thermally and air-stable in solution. Illumination with a 450 nm light source induces significant photodetachment of the coordinated NO (ϕNO = 0...
November 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29118577/associations-between-occupational-inhalation-risks-and-feno-levels-in-airway-obstruction-patients-results-from-the-national-health-and-nutrition-examination-survey-2007-2012
#7
Yi-Chih Huang, Mei-Chen Yang
Purpose: To investigate associations between occupational inhalation risks and fractional exhaled nitric oxide (FeNO) levels in patients with chronic obstructive pulmonary disease (COPD). Patients and methods: Data of 16,486 subjects who had undergone spirometry with pre-bronchodilator and post-bronchodilator lung function assessment were retrieved from the National Health and Nutrition Examination Survey, 2007-2012 database. After excluding 2,638 subjects with missing spirometry values, data of 13,336 subjects were included for analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29110960/the-clinical-role-of-fractional-exhaled-nitric-oxide-in-asthma-control
#8
Suguru Sato, Junpei Saito, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Xintao Wang, Yoshinori Tanino, Mitsuru Munakata
BACKGROUND: The potential role and characteristics of fractional exhaled nitric oxide (FeNO) remain unclear in the treatment of asthma. OBJECTIVE: To explore the clinical role of FeNO in asthmatic treatment. METHODS: We evaluated whether the mean or change of FeNO levels in the treatment period is associated with other conventional control parameters and predicted some clinical outcomes of asthma. We retrospectively analyzed the mean and percentage change of FeNO levels in the first 5 measurements at our hospital...
October 27, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29108939/feno-and-suspected-asthma-better-to-identify-responsiveness-to-treatment-than-to-label-with-a-diagnosis
#9
Kjell Alving
No abstract text is available yet for this article.
November 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29108938/fractional-exhaled-nitric-oxide-as-a-predictor-of-response-to-inhaled-corticosteroids-in-patients-with-non-specific-respiratory-symptoms-and-insignificant-bronchodilator-reversibility-a-randomised-controlled-trial
#10
David B Price, Roland Buhl, Adrian Chan, Daryl Freeman, Elizabeth Gardener, Clifford Godley, Kevin Gruffydd-Jones, Lorcan McGarvey, Ken Ohta, Dermot Ryan, Jörgen Syk, Ngiap Chuan Tan, TzeLee Tan, Mike Thomas, Sen Yang, Priyanka Raju Konduru, Marcus Ngantcha, Martina Stagno d'Alcontres, Therese S Lapperre
BACKGROUND: Chronic non-specific respiratory symptoms are difficult to manage. This trial aimed to evaluate the association between baseline fractional exhaled nitric oxide (FeNO) and the response to inhaled corticosteroids in patients with non-specific respiratory symptoms. METHODS: In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged 18-80 years, with cough, wheeze, or dyspnoea and less than 20% bronchodilator reversibility across 26 primary care centres and hospitals in the UK and Singapore...
November 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29099085/eburicoic-acid-a-triterpenoid-compound-from-antrodia-camphorata-displays-antidiabetic-and-antihyperlipidemic-effects-in-palmitate-treated-c2c12-myotubes-and-in-high-fat-diet-fed-mice
#11
Cheng-Hsiu Lin, Yueh-Hsiung Kuo, Chun-Ching Shih
This study was designed to investigate the antidiabetic and antihyperlipidemic effects and mechanisms of eburicoic acid (TRR); one component of Antrodia camphorata in vitro and in an animal model for 14 weeks. Expression levels of membrane glucose transporter type 4 (GLUT4); phospho-5'-adenosine monophosphate-activated protein kinase (AMPK)/total AMPK; and phospho-Akt/total-Akt in insulin-resistant C2C12 myotube cells were significantly decreased by palmitate; and such decrease was prevented and restored by TRR at different concentrations...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29098476/influence-of-air-pollution-on-airway-inflammation-and-disease-activity-in-childhood-systemic-lupus-erythematosus
#12
Andressa Guariento Ferreira Alves, Maria Fernanda de Azevedo Giacomin, Alfésio Luis Ferreira Braga, Adriana Maluf Elias Sallum, Luiz Alberto Amador Pereira, Luis Carlos Farhat, Fernando Louzada Strufaldi, Ana Julia de Faria Coimbra Lichtenfels, Tômas de Santana Carvalho, Naomi Kondo Nakagawa, Clovis Artur Silva, Sylvia Costa Lima Farhat
Exposure to fine particles may trigger pulmonary inflammation/systemic inflammation. The objective of this study was to investigate the association between daily individual exposure to air pollutants and airway inflammation and disease activity in childhood-onset systemic lupus erythematosus (cSLE) patients. A longitudinal panel study was carried out in 108 consecutive appointments with cSLE patients without respiratory diseases. Over four consecutive weeks, daily individual measures of nitrogen dioxide (NO2), fine particulate matter (PM2...
November 2, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#13
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29072882/rita-the-italian-severe-uncontrolled-asthma-registry
#14
Sara Maio, Sandra Baldacci, Megon Bresciani, Marzia Simoni, Manuela Latorre, Nicola Murgia, Fabrizio Spinozzi, Mariachiara Braschi, Leonardo Antonicelli, Barbara Brunetto, Patrizia Iacovacci, Paolo Roazzi, Carlo Pini, Mario Pata, Lidia La Grasta, Pierluigi Paggiaro, Giovanni Viegi
BACKGROUND: The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. METHODS: 493 adult patients from 27 Italian centres (recruited in 2011-2014) were analyzed. RESULTS: Mean age was 53.8yrs. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40yrs); the mean age for asthma symptoms onset was 30...
October 26, 2017: Allergy
https://www.readbyqxmd.com/read/29068321/relationship-between-total-serum-immunoglobulin-e-levels-fractional-exhaled-breath-nitric-oxide-levels-and-absolute-blood-eosinophil-counts-in-atopic-and-non-atopic-asthma-a-controlled-comparative-study
#15
Sanjeet Krishna Shrestha, Arne Drews, Lucky Sharma, Subash Pant, Sanjeev Shrestha, Arpana Neopane
ABSTRACT Introduction Asthma is a prevalent non communicable disease both in low and high income countries, including Nepal. Total serum immunoglobulin E levels and peripheral blood absolute eosinophil counts are known inflammatory markers of asthma. And Fractional Exhaled Nitric Oxide measure in breath has also been proposed as a non-invasive biomarker to assess eosinophilic airway inflammation. This study explores the correlation between these three variables with intent that one may replace the other in resource limited setup...
October 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29066290/phenotype-classification-using-the-combination-of-lung-sound-analysis-and-fractional-exhaled-nitric-oxide-for-evaluating-asthma-treatment
#16
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
BACKGROUND: We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200-400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. METHODS: A total of 233 patients with bronchial asthma were included...
October 21, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29053273/distinguishing-nitro-vs-nitrito-coordination-in-cytochrome-c-using-vibrational-spectroscopy-and-density-functional-theory
#17
Zach N Nilsson, Brian L Mandella, Kakali Sen, Demet Kekilli, Michael A Hough, Pierre Moënne-Loccoz, Richard W Strange, Colin R Andrew
Nitrite coordination to heme cofactors is a key step in the anaerobic production of the signaling molecule nitric oxide (NO). An ambidentate ligand, nitrite has the potential to coordinate via the N- (nitro) or O- (nitrito) atoms in a manner that can direct its reactivity. Distinguishing nitro vs nitrito coordination, along with the influence of the surrounding protein, is therefore of particular interest. In this study, we probed Fe(III) heme-nitrite coordination in Alcaligenes xylosoxidans cytochrome c' (AXCP), an NO carrier that excludes anions in its native state but that readily binds nitrite (Kd ∼ 0...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29052979/tetranuclear-fe-clusters-with-a-varied-interstitial-ligand-effects-on-the-structure-redox-properties-and-nitric-oxide-activation
#18
Christopher J Reed, Theodor Agapie
A new series of tetranuclear Fe clusters displaying an interstitial μ4-F ligand was prepared for a comparison to previously reported μ4-O analogues. With a single nitric oxide (NO) coordinated as a reporter of small-molecule activation, the μ4-F clusters were characterized in five redox states, from Fe(II)3{FeNO}(8) to Fe(III)3{FeNO}(7), with NO stretching frequencies ranging from 1680 to 1855 cm(-1), respectively. Despite accessing more reduced states with an F(-) bridge, a two-electron reduction of the distal Fe centers is necessary for the μ4-F clusters to activate NO to the same degree as the μ4-O system; consequently, NO reactivity is observed at more positive potentials with μ4-O than μ4-F...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29042872/accuracy-of-maximal-expiratory-flow-volume-curve-curvilinearity-and-fractional-exhaled-nitric-oxide-for-detection-of-children-with-atopic-asthma
#19
Sang Hoo Park, Min Ji Im, Sang-Yong Eom, Youn-Soo Hahn
PURPOSE: Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals. METHODS: FeNO and angle β, which characterizes the general configuration of the MEFV curve, were determined in 119 steroid-naïve individuals with atopic asthma aged 8 to 16 years, and in 92 age-matched healthy controls...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29042800/postpartum-airway-responsiveness-and-exacerbation-of-asthma-during-pregnancy-a-pilot-study
#20
Zarqa Ali, Lisbeth Nilas, Charlotte Suppli Ulrik
BACKGROUND: Airway responsiveness and inflammation are associated with the clinical manifestations of asthma and the response to pharmacological therapy. OBJECTIVE: To investigate if airway responsiveness and inflammatory characteristics are related to asthma exacerbations during pregnancy. MATERIALS AND METHODS: In women with asthma who were prescribed controller medication and monitored closely during pregnancy, the risk of exacerbations was analyzed in relation to postpartum measures of fractional exhaled nitric oxide (FENO), skin prick test reactivity, static and dynamic lung volumes, diffusing capacity for carbon monoxide, bronchial responsiveness to inhaled mannitol, and inflammatory characteristics in induced sputum...
2017: Journal of Asthma and Allergy
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