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https://www.readbyqxmd.com/read/29929000/telmisartan-generates-ros-dependent-upregulation-of-death-receptor-5-to-sensitize-trail-in-lung-cancer-via-inhibition-of-autophagy-flux
#1
Mohammad Rasheduzzaman, Ji-Hong Moon, Ju-Hee Lee, Uddin Md Nazim, Sang-Youel Park
Telmisartan broadly used for the treatment of hypertension that is also known for its anticancer properties. TRAIL has the potential to kill tumor cells with minimal toxicity in normal cells by binding to death receptors, DR4 and DR5. Unfortunately, these TRAIL-death receptors have failed as most human cancers are resistant to TRAIL-mediated apoptosis. In this study, we evaluated telmisartan as a novel TRAIL-DR5-targeting agent with the aim of rendering TRAIL-based cancer therapies more active. Herein, we demonstrated that telmisartan could sensitize TRAIL and enhance NSCLC tumor cell death...
June 18, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29928970/gallic-acid-coated-sliver-nanoparticle-alters-the-expression-of-radiation-induced-epithelial-mesenchymal-transition-in-non-small-lung-cancer-cells
#2
S N Sunil Gowda, S Rajasowmiya, V Vadivel, S Banu Devi, A Celestin Jerald, S Marimuthu, N Devipriya
BACKGROUND: Radiotherapy is the most widely used treatment method for treating cancer with or without surgery and chemotherapy. In lung cancer, it is one of the important treatment steps in excising the tumor from the lung tissue; unfortunately, radiation can induce epithelial- mesenchymal transition (EMT), a typical physiological process in which cuboidal shaped epithelial cell loses its phenotype and acquires mesenchymal-like phenotype thus, increases the metastasis progression in the body...
June 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29928969/long-term-exposure-to-environmental-concentrations-of-diesel-exhaust-particles-does-not-impact-the-phenotype-of-human-bronchial-epithelial-cells
#3
Camille C Savary, Nessrine Bellamri, Claudie Morzadec, Sophie Langouët, Valérie Lecureur, Laurent Vernhet
Chronic exposure to diesel engine exhausts is associated with an increased risk of pulmonary diseases including lung cancer. Diesel engine exhausts contain large amounts of diesel exhaust particles (DEP) on which are adsorbed several carcinogenic compounds such as polycyclic aromatic hydrocarbons. Acute toxicity of high concentrations of DEP has been largely demonstrated in various in vitro cellular models. In contrast, the cellular and molecular impacts of low environmental concentrations of DEP on the phenotype of chronically exposed lung epithelial cells remain to be investigated...
June 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29928911/cadm1-is-a-diagnostic-marker-in-early-stage-mycosis-fungoides-multicenter-study-of-58-cases
#4
Akihiko Yuki, Satoru Shinkuma, Ryota Hayashi, Hiroki Fujikawa, Taisuke Kato, Erina Homma, Yohei Hamade, Osamu Onodera, Masao Matsuoka, Hiroshi Shimizu, Hiroaki Iwata, Riichiro Abe
BACKGROUND: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene in human non-small-cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma (ATLL). OBJECTIVE: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF...
June 18, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29928883/suppression-of-cleavage-factor-im-25-promotes-the-proliferation-of-lung-cancer-cells-through-alternative-polyadenylation
#5
Jingjing Huang, Tingting Weng, Junsuk Ko, Ning-Yuan Chen, Yu Xiang, Kelly Volcik, Leng Han, Michael R Blackburn, Xiang Lu
BACKGROUND: Non-small cell lung cancer (NSCLC) is a life-threatening disease that has a poor prognosis and low survival rate. Cleavage factor Im 25 (CFIm25) is a RNA-binding protein that if down-regulated causes 3'UTR shortening and thus promotes the transcript stability of target genes. It is not clear whether CFIm25 and alternative polyadenylation (APA) play a role during cancer development. The purpose of this study is to explore the role of CFIm25 in lung cancer cell proliferation...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928852/oxygen-use-after-lung-cancer-surgery
#6
Daniel G Nicastri, Naomi Alpert, Bian Liu, Andrea Wolf, Emanuela Taioli, Benjamin V Tran, Raja Flores
BACKGROUND: There are no published reports on predictors of oxygen (O2 ) use after lung cancer surgery. The prospect of O2 use following lung cancer surgery may affect a patient's therapy choice. METHODS: The Surveillance, Epidemiology, and End Results -Medicare (SEER-Medicare) dataset was queried to identify patients diagnosed with primary lung cancer (stage I/II) who underwent surgical resection from 1994-2010. Patients with a second resection within 6 months of their first and those with preoperative O2 use were excluded...
June 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29928807/prevalence-and-determinants-of-smoking-and-secondhand-smoke-exposure-in-a-rural-population-of-central-greece-a-cross-sectional-study
#7
Chrysovalantis Stafylis, George Rachiotis, Antonis Katsioulis, Varvara A Mouchtouri, Christos Hadjichristodoulou
INTRODUCTION: Smoking is one of the most important risk factors for heart and lung disease and is responsible for many forms of cancer. The resulting morbidity and mortality weigh heavily upon countries with high prevalence, such as Greece. According to the Global Adult Tobacco Survey (GATS) Greece, 38.2% of Greeks aged ≥15 years, namely 51.2% of men and 25.7% of women, are smokers. Smoking is also common among the young and people of high education. Despite laws prohibiting smoking at indoor places, exposure to environmental tobacco is very high both in private and public places...
June 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29928803/discovery-of-n-4-quinolin-4-yloxy-phenyl-benzenesulfonamides-as-novel-axl-kinase-inhibitors
#8
István Szabadkai, Robert Torka, Rita Garamvölgyi, Ferenc Baska, Pál Gyulavári, Sándor Boros, Eszter Illyés, Axel Choidas, Axel Ullrich, László Őrfi
The overexpression of AXL kinase has been described in many types of cancer. Due to its role in proliferation, survival, migration and resistance AXL represents a promising target in the treatment of the disease. In this study we present a novel compound family which successfully targets the AXL kinase. Through optimization and detailed SAR studies we developed low nanomolar inhibitors and after further biological characterization we identified a selective and applicable AXL kinase inhibitor with favorable pharmacokinetic profile...
June 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29928786/antitumor-perspectives-of-oleuropein-and-its-metabolite-hydroxytyrosol-recent-updates
#9
REVIEW
Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Shaista Khan, Muhammad Wasim Sajid, Rai Muhammad Amir
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis...
June 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29928517/nutritional-status-and-muscle-dysfunction-in-chronic-respiratory-diseases-stable-phase-versus-acute-exacerbations
#10
REVIEW
Joaquim Gea, Antoni Sancho-Muñoz, Roberto Chalela
Nutritional abnormalities are frequent in different chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), interstitial fibrosis and lung cancer, having important clinical consequences. However, nutritional abnormalities often remained underdiagnosed due to the relative lack of awareness of health professionals. Therefore, systematic anthropometry or even better, assessment of body composition, should be performed in all patients with chronic respiratory conditions, especially following exacerbation periods when malnutrition becomes more accentuated...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928483/mir-146a-suppresses-5-lipoxygenase-activating-protein-flap-expression-and-leukotriene-b4-production-in-lung-cancer-cells
#11
Joseph R Iacona, Nicholas J Monteleone, Carol S Lutz
Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively. PGs and LTs are lipid signaling molecules that have been implicated in various diseases, including multiple cancers. 5-LO and its activating protein (FLAP) work together in the first two conversion steps of LT production. Previous work has suggested a role for LTs in cancer development and progression. MicroRNAs (miRNAs) are small RNA molecules that negatively regulate gene expression post-transcriptionally, and have previously been shown to be involved in cancer...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928456/the-role-of-radiation-therapy-in-the-management-of-small-cell-lung-cancer
#12
REVIEW
Markus Glatzer, Sabine Schmid, Marco Radovic, Martin Früh, Paul Martin Putora
Small cell lung cancer (SCLC) is a very aggressive form of lung cancer. SCLC treatment requires multidisciplinary management and timely treatment. Radiation therapy is an important part of management of all stages of SCLC, in the curative as well as in the palliative setting. The role of radiation therapy in all stages of SCLC has changed in recent years; this article describes these changes and highlights the role of radiation therapy in the management of SCLC.
December 2017: Breathe
https://www.readbyqxmd.com/read/29928436/neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-may-aid-in-identifying-patients-with-non-small-cell-lung-cancer-and-predicting-tumor-node-metastasis-stages
#13
Fei Xu, Pengliang Xu, Wenqiang Cui, Weiyi Gong, Ying Wei, Baojun Liu, Jingcheng Dong
The present study aimed to identify a high-risk population with non-small cell lung cancer (NSCLC) and to predict TNM stages using the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR). This retrospective study included preoperative data of 171 patients and 105 controls. Compared with healthy controls, patients with NSCLC had higher levels of NLR and PLR (NLR, 2.719±0.183 vs. 1.813±0.079, P<0.01; PLR, 135.800±4.778 vs. 112.000±5.651, P<0.01, respectively). The associations between Tumor-Node-Metastasis stages and the aforementioned parameters were detected (both P<0...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928434/downregulation-of-glutathione-s-transferase-a1-suppressed-tumor-growth-and-induced-cell-apoptosis-in-a549-cell-line
#14
Huan Liu, Zhouping Yang, Linquan Zang, Guixiang Wang, Sigui Zhou, Guifang Jin, Zhicheng Yang, Xuediao Pan
Glutathione S-transferase A1 (GSTA1) is a phase II detoxification enzyme and serves a crucial role in anti-cancer drug resistance. In our previous study, GSTA1 was identified to be highly expressed in various subtypes of non-small-cell lung cancer cell lines compared with human embryonic lung fibroblast cell line MRC-5. The aim of the present study was to investigate the effect of GSTA1 expression on the proliferation and apoptosis of A549 cells. GSTA1 expression was knocked down or with overexpressed using lentivirus particles...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928432/upregulation-of-circ_001569-predicts-poor-prognosis-and-promotes-cell-proliferation-in-non-small-cell-lung-cancer-by-regulating-the-wnt-%C3%AE-catenin-pathway
#15
Lingchi Ding, Weidong Yao, Junguo Lu, Jun Gong, Xiaodong Zhang
Circular RNAs (circRNAs) are a large class of RNAs that have previously been identified to be involved in certain diseases, including the development of cancer. However, the role of circ_001569 in non-small cell lung cancer (NSCLC) remains unknown. In the present study, it was demonstrated that expression levels of circ_001569 were significantly increased in NSCLC tissues compared with in adjacent normal tissues. Increased circ_001569 expression was closely associated with tumor differentiation, lymph node metastasis and Tumor-Node-Metastasis classification in NSCLC...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928414/hypoxia-exposure-upregulates-malat-1-and-regulates-the-transcriptional-activity-of-ptb-associated-splicing-factor-in-a549-lung-adenocarcinoma-cells
#16
Ling Hu, Jing Tang, Xiaohuan Huang, Tao Zhang, Xiaoling Feng
Hypoxia has been reported to be a critical microenvironmental factor that induces cancer metastasis and proliferation in gastric, liver and hepatic cancers; however, the underlying mechanisms of this are largely unknown. Long noncoding RNAs (lncRNAs) have emerged as crucial factors of several aspects of tumor malignancy, including tumorigenesis, metastasis and chemoresistance. However, the potential association of lncRNAs with hypoxia-induced cancer malignancy remains to be determined. In the present study, the differential expression of lncRNAs following the induction of hypoxia in A549 lung adenocarcinoma cells was analyzed reverse transcription-quantitative polymerase chain reaction...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928412/tumor-necrosis-factor-related-apoptosis-inducing-ligand-additive-with-iodine-131-of-inhibits-non-small-cell-lung-cancer-cells-through-promoting-apoptosis
#17
Ning Yang, Shuzhan Yao, Dong Liu
Non-small-cell lung cancer (NSCLC) accounts for ~80% of human lung cancer cases and is the most common cause of cancer-associated mortality worldwide. Reports have indicated that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Iodine-131 (I-131) can induce tumor cell apoptosis. The purpose of the present study was to investigate the additive efficacy of TRAIL and I-131 on NSCLC cells. The present study demonstrated that additive treatment of TRAIL and I-131 (TRAIL-I-131) significantly inhibited the growth and aggressiveness of NSCLC cells compared with single TRAIL or I-131 treatment...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928408/mir-196b-promotes-lung-cancer-cell-migration-and-invasion-through-the-targeting-of-gata6
#18
Hongli Li, Chao Feng, Songtao Shi
MicroRNAs (miRNAs) have been proven to regulate gene expression at the protein translation level. miRNA abnormal expression has been associated with the development of lung cancer. In the present study, we aimed to investigate the mechanism of miR-196 in non-small cell lung cancer (NSCLC). The miR-196b and GATA-6 (GATA6) expression levels were examined in NSCLC by RT-qPCR and western blot analysis. Transwell assay was used to assess cell migration and invasion. Moreover, the specific target of miR-196b in NSCLC was verified by the luciferase reporter assay...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928404/efficacy-of-radiotherapy-on-intermediate-and-advanced-lung-cancer-and-its-effect-on-dynamic-changes-of-serum-vascular-endothelial-growth-factor-and-matrix-metalloproteinase-9
#19
Guowei Ding, Yongchao Liu, Chunmei Liang
The present study intended to investigate efficacy of radiotherapy in the treatment of intermediate and advanced stage lung cancer and the effects on serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9). Serum levels of VEGF and MMP-9 of 77 patients with intermediate or advanced lung cancer were detected before and after the treatment. At the same time, 19 healthy people were selected as the control group. Gelatin zymography was applied to measure the activity of serum MMP-9, ELISA was performed to detect the VEGF and MMP-9 levels in the peripheral blood and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to measure the messenger RNA (mRNA) levels of VEGF and MMP-9 in serum...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928394/prediction-and-identification-of-transcriptional-regulatory-elements-at-the-lung-cancer-specific-dkk1-locus
#20
Yan Gao, Xian Du, Jing Zeng, Ruimin Wu, Yijia Chen, Fuyan Li, Wei Li, Hong Zhou, Yi Yang, Zhijun Pei
The glycoprotein dickkopf 1 (DKK1) is highly expressed in lung cancer cell lines and tissues. Our previous study demonstrated that DKK1 promoter activity is low in lung cancer cell lines. This may be because it lacks the necessary transcriptional regulatory elements (TREs) required for higher activity levels. However, it is difficult to computationally predict functionally significant TREs, as TREs from different locations can affect large segments of distant DNA. The Encyclopedia of DNA Elements project features multiple integrated technologies and approaches for the discovery and definition of functional elements, including enhancer elements and enhancer-blocking insulators...
July 2018: Oncology Letters
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