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https://www.readbyqxmd.com/read/28826097/the-prognostic-landscape-of-tumor-infiltrating-immune-cell-and-immunomodulators-in-lung-cancer
#1
Xinyan Liu, Shucai Wu, Yonghui Yang, Min Zhao, Guiyun Zhu, Zhihua Hou
Tumor-infiltrating immune cells are closely associated with clinical outcome. However, immunohistochemistry-based analysis of tumor infiltrates can be misleading as the representative marker of an immune subpopulation might be expressed in other cell types. In this study, based on a metagene approach (known as CIBERSORT) and an online databse, The Cancer Immunome Atlas (https://tcia.at/), we comprehensively analyzed the tumor-infiltrating immune cells present in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC)...
August 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28826075/contamination-by-oil-crude-extraction-refinement-and-their-effects-on-human-health
#2
REVIEW
Maria Isabel Ramirez, Ana Paulina Arevalo, Santiago Sotomayor, Natalia Bailon-Moscoso
The harmful effects of oil on various species of flora and fauna have been studied extensively; however, few studies have studied the effects of oil exposure on human health. The objective of this research was to collect information on the acute health effects and serious psychological symptoms of the possible consequences of such exposure to crude oil. Some studies focused on the composition of different chemicals used in the extraction process, and wastes generated proved to be highly harmful to human health...
August 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28825498/evaluation-of-coping-as-a-mediator-of-the-relationship-between-stressful-life-events-and-cancer-related-distress
#3
Dale J Langford, Bruce Cooper, Steven Paul, Janice Humphreys, Carolyn Keagy, Yvette P Conley, Marilyn J Hammer, Jon D Levine, Fay Wright, Michelle Melisko, Christine Miaskowski, Laura B Dunn
OBJECTIVE: Lifetime stressful life events (SLEs) may predispose oncology patients to cancer-related distress (i.e., intrusive thoughts, hyperarousal, avoidance). Coping may influence cancer-related distress by mediating this relationship. This study sought to (a) determine the prevalence and impact of lifetime SLEs among oncology outpatients receiving chemotherapy and (b) examine the relationship between SLEs and cancer-related distress and the mediating role of coping on this relationship...
August 21, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28825409/reply-to-comment-on-canine-scent-detection-for-the-diagnosis-of-lung-cancer-in-a-screening-like-situation
#4
K Hackner, P Errhalt, T Doll
No abstract text is available yet for this article.
August 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28825402/comment-on-canine-scent-detection-for-the-diagnosis-of-lung-cancer-in-a-screening-like-situation
#5
Glenn Ferguson
No abstract text is available yet for this article.
August 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28825378/immunotherapy-induced-autoimmune-hypophysitis
#6
Gautam Valecha, Manisha Pant, Uroosa Ibrahim, Jean P Atallah
Autoimmune hypophysitis is an immune-related adverse event of immune checkpoint inhibitors. In this article, we present the case of a 58-year-old female patient who presented to the emergency room with gradually worsening nonspecific symptoms of headache, nausea, vomiting and decreased oral intake of one week duration. The patient had been diagnosed with relapsed extensive stage small cell lung cancer. She was being treated with a combination of ipilimumab and nivolumab after progression on chemotherapy. Gadolinium-enhanced magnetic resonance imaging of head revealed pituitary enlargement up to 1...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28825377/effectiveness-of-adjuvant-carboplatin-based-chemotherapy-compared-to-cisplatin-in-non-small-cell-lung-cancer
#7
Valérie Couillard-Montminy, Pierre-Yves Gagnon, Sebastien Fortin, Jimmy Côté
Background Cisplatin and vinorelbine given intravenously is a well-established adjuvant chemotherapy regimen after surgery for early non-small cell lung cancer. However, few validated alternatives exist when cisplatin is not indicated or tolerated. Carboplatin is frequently used in this setting. We evaluated the 5-year overall survival, progression-free survival and toxicity in patients treated for stage IB to IIIB resected non-small cell lung cancer receiving adjuvant carboplatin-based chemotherapy compared to cisplatin in association with vinorelbine...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28825374/nivolumab-induced-aplastic-anemia-a-case-report-and-literature-review
#8
Rachel R Comito, Lynette A Badu, Nicholas Forcello
Directed immunotherapy at the programmed cell death-1 receptor has demonstrated efficacy in non-small-cell lung cancer, metastatic melanoma, and various other malignancies. Immune checkpoint inhibitors are innovative therapies producing some impressive clinical responses with a more manageable adverse effect profile when compared to traditional chemotherapy. The more common adverse effects associated with these agents include fatigue, rash, myalgia, pyrexia, and cough, but less common yet serious adverse effects have included immune-mediated colitis, pneumonitis, hepatitis, type 1 diabetes, and encephalitis...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28825373/the-role-of-the-ataxia-telangiectasia-mutated-gene-in-lung-cancer-recent-advances-in-research
#9
Yanling Xu, Peng Gao, Xuejiao Lv, Lin Zhang, Jie Zhang
Lung cancer is the leading cause of death due to cancer worldwide. It is estimated that approximately 1.2 million new cases of lung cancer are diagnosed each year. Early detection and treatment are crucial for improvements in both prognosis and quality of life of lung cancer patients. The ataxia telangiectasia mutated (ATM) gene is a cancer-susceptibility gene that encodes a key apical kinase in the DNA damage response pathway. It has recently been shown to play an important role in the development of lung cancer...
August 1, 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28825166/adherence-to-the-2015-dutch-dietary-guidelines-and-risk-of-non-communicable-diseases-and-mortality-in-the-rotterdam-study
#10
Trudy Voortman, Jessica C Kiefte-de Jong, M Arfan Ikram, Bruno H Stricker, Frank J A van Rooij, Lies Lahousse, Henning Tiemeier, Guy G Brusselle, Oscar H Franco, Josje D Schoufour
We aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. We studied 9701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45 years and over [median 64.1 years (95%-range 49.0-82.8)]. Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200 g/day), fruit (≥200 g/day), whole-grains (≥90 g/day), legumes (≥135 g/week), nuts (≥15 g/day), dairy (≥350 g/day), fish (≥100 g/week), tea (≥450 mL/day), ratio whole-grains:total grains (≥50%), ratio unsaturated fats and oils:total fats (≥50%), red and processed meat (<300 g/week), sugar-containing beverages (≤150 mL/day), alcohol (≤10 g/day) and salt (≤6 g/day)...
August 19, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28825044/exploiting-the-ref-1-ape1-node-in-cancer-signaling-and-other-diseases-from-bench-to-clinic
#11
Fenil Shah, Derek Logsdon, Richard A Messmann, Jill C Fehrenbacher, Melissa L Fishel, Mark R Kelley
Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a critical node in tumor cells, both as a redox regulator of transcription factor activation and as part of the DNA damage response. As a redox signaling protein, Ref-1/APE1 enhances the transcriptional activity of STAT3, HIF-1α, nuclear factor kappa B, and other transcription factors to promote growth, migration, and survival in tumor cells as well as inflammation and angiogenesis in the tumor microenvironment. Ref-1/APE1 is activated in a variety of cancers, including prostate, colon, pancreatic, ovarian, lung and leukemias, leading to increased aggressiveness...
2017: NPJ Precis Oncol
https://www.readbyqxmd.com/read/28824912/comorbid-conditions-in-idiopathic-pulmonary-fibrosis-recognition-and-management
#12
REVIEW
Justin M Oldham, Harold R Collard
Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial pneumonia of unknown etiology, primarily affects older adults and leads to a progressive decline in lung function and quality of life. With a median survival of 3-5 years, IPF is the most common and deadly of the idiopathic interstitial pneumonias. Despite the poor survivorship, there exists substantial variation in disease progression, making accurate prognostication difficult. Lung transplantation remains the sole curative intervention in IPF, but two anti-fibrotic therapies were recently shown to slow pulmonary function decline and are now approved for the treatment of IPF in many countries around the world...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28824875/sex-differences-and-bone-metastases-of-breast-lung-and-prostate-cancers-do-bone-homing-cancers-favor-feminized-bone-marrow
#13
REVIEW
Mary C Farach-Carson, Sue-Hwa Lin, Theresa Nalty, Robert L Satcher
Sex-associated differences in bone metastasis formation from breast, lung, and prostate cancer exist in clinical studies, but have not been systematically reviewed. Differences in the bone marrow niche can be attributed to sexual dimorphism, to genetic variations that affect sex hormone levels, or to the direct effects of sex hormones, natural or exogenously delivered. This review describes the present understanding of sex-associated and sex hormone level differences in the marrow niche and in formation of bone metastasis during the transition of these three cancers from treatable disease to an often untreatable, lethal metastatic one...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28824725/mutational-landscapes-of-smoking-related-cancers-in-caucasians-and-african-americans-precision-oncology-perspectives-at-wake-forest-baptist-comprehensive-cancer-center
#14
Ville Kytola, Umit Topaloglu, Lance D Miller, Rhonda L Bitting, Michael M Goodman, Ralph B D Agostino, Rodwige J Desnoyers, Carol Albright, George Yacoub, Shadi A Qasem, Barry DeYoung, Vesteinn Thorsson, Ilya Shmulevich, Meng Yang, Anastasia Shcherban, Matthew Pagni, Liang Liu, Matti Nykter, Kexin Chen, Gregory A Hawkins, Stefan C Grant, W Jeffrey Petty, Angela Tatiana Alistar, Edward A Levine, Edgar D Staren, Carl D Langefeld, Vincent Miller, Gaurav Singal, Robin M Petro, Mac Robinson, William Blackstock, Bayard L Powell, Lynne I Wagner, Kristie L Foley, Edward Abraham, Boris Pasche, Wei Zhang
Background: Cancers related to tobacco use and African-American ancestry are under-characterized by genomics. This gap in precision oncology research represents a major challenge in the health disparities in the United States. Methods: The Precision Oncology trial at the Wake Forest Baptist Comprehensive Cancer Center enrolled 431 cancer patients from March 2015 to May 2016. The composition of these patients consists of a high representation of tobacco-related cancers (e.g., lung, colorectal, and bladder) and African-American ancestry (13...
2017: Theranostics
https://www.readbyqxmd.com/read/28824722/blood-droplet-based-cancer-diagnosis-via-proteolytic-activity-measurement-in-cancer-progression
#15
Jin Woo Choi, Hyungbeen Lee, Gyudo Lee, Yi Rang Kim, Myung-Ju Ahn, Heung Jae Park, Kilho Eom, Taeyun Kwon
Matrix metalloproteinase (MMP) is a key marker and target molecule for cancer diagnosis, as MMP is able to cleave peptide chains resulting in degradation of extracellular matrix (ECM), a necessary step for cancer development. In particular, MMP2 has recently been recognized as an important biomarker for lung cancer. Despite the important role of detecting MMP molecules in cancer diagnosis, it is a daunting task to quantitatively understand a correlation between the status of cancer development and the secretion level of MMP in a blood droplet...
2017: Theranostics
https://www.readbyqxmd.com/read/28824453/hoxc10-promotes-the-metastasis-of-human-lung-adenocarcinoma-and-indicates-poor-survival-outcome
#16
Xiao-Lei Tang, Bang-Xian Ding, Ying Hua, Hao Chen, Tao Wu, Zhang-Quan Chen, Chun-Hui Yuan
Background: As master regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and indicates poor survival outcome. However, the role of HOXC10 in lung adenocarcinoma still unclear. Methods: HOXC10 expression was evaluated in 63 primary lung adenocarcinoma tissues from our local hospital, and further systematically confirmed in lung cancer tissues from six GEO datasets (GSE19188, GSE31210, GSE10072, GSE7670, GSE32863, GSE30219), and Kaplan-Meier plotter database...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28824314/independent-prognostic-value-of-hypoxia-inducible-factor-1-alpha-expression-in-small-cell-lung-cancer
#17
Chang-Sheng Lin, Tu-Chen Liu, Ming-Tsung Lee, Shun-Fa Yang, Thomas Chang-Yao Tsao
Hypoxia is an important factor in tumor angiogenesis, metastasis, and resistance to chemotherapy or radiotherapy, and may be an indicator of poor prognosis. The transcription factor hypoxia-inducible factor 1 (HIF-1) is the key regulator of the hypoxic state. This study was designed to evaluate the prognostic value of HIF-1α expression in small cell lung cancer (SCLC). Forty-three paraffin-embedded biopsy materials were examined using immunohistochemistry. Our results indicated that the expression of HIF-1α was high in males, and patients with poor Eastern Cooperative Oncology Group (ECOG) performance status and metastases...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28824300/the-emsy-gene-collaborates-with-ccnd1-in-non-small-cell-lung-carcinogenesis
#18
Onur Baykara, Nejat Dalay, Burak Bakir, Pelin Bulut, Kamil Kaynak, Nur Buyru
Background: Lung cancer is the leading cause of cancer deaths. The main risk factor is smoking but the risk is also associated with various genetic and epigenetic components in addition to environmental factors. Increases in the gene copy numbers due to chromosomal amplifications constitute a common mechanism for oncogene activation. A gene-dense region on chromosome 11q13 which harbors four core regions that are frequently amplified, has been associated with various types of cancer. The important cell cycle regulatory protein cyclin D1 (CCND1) is an essential driver of the first core region of the Chr11q13 amplicon...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28824085/calculation-accuracy-of-gross-tumor-volume-at-the-diaphragm-boundary-evaluated-using-respiratory-gated-pet-ct
#19
Shuto Nakazawa, Takuro Umeda, Noriaki Miyaji, Kenta Miwa, Kei Wagatsuma, Kazuki Motegi, Tomohiro Takiguchi, Takashi Terauchi, Mitsuru Koizumi, Keisuke Usui, Keisuke Sasai
OBJECTIVE: The present study aimed to clarify gross tumor volume (GTV) contouring accuracy at the diaphragm boundary using respiratory-gated PET/CT. METHODS: The lung/diaphragm boundary was simulated using a phantom containing (18)F solution (10.6 kBq/mL). Tumors were simulated using spheres (diameter, 11-38 mm) containing (18)F and located at the positions of the lungs and liver. The tumor background ratios (TBR) were 2, 4, and 8. The phantom was moved from the superior to inferior direction with a 20-mm motion displacement at 3...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28824067/isolated-adrenocorticotropic-hormone-deficiency-caused-by-nivolumab-in-a-patient-with-metastatic-lung-cancer
#20
Kazuhiko Takaya, Miwa Sonoda, Ayako Fuchigami, Toru Hiyoshi
Nivolumab has promising efficacy for treating various advanced malignant tumors, although it has been reported to induce a wide range of autoimmune adverse effects. We herein report the case of a patient with metastatic lung adenocarcinoma who developed adrenal insufficiency after 12 cycles of nivolumab treatment. Endocrine test results supported a diagnosis of isolated adrenocorticotropic hormone deficiency due to hypophysitis, and replacement therapy using hydrocortisone has been successful. Although hypophysitis is a rare immune-related adverse event that is associated with nivolumab therapy, clinical awareness is essential, as this condition can be life-threatening and requires prompt treatment...
August 21, 2017: Internal Medicine
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