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https://www.readbyqxmd.com/read/29031230/astatine-211-labeled-anti-her2-5f7-single-domain-antibody-fragment-conjugates-radiolabeling-and-preliminary-evaluation
#1
Jaeyeon Choi, Ganesan Vaidyanathan, Eftychia Koumarianou, Choong Mo Kang, Michael R Zalutsky
INTRODUCTION: Derived from heavy chain only camelid antibodies, ~15-kDa single-domain antibody fragments (sdAbs) are an attractive platform for developing molecularly specific imaging probes and targeted radiotherapeutics. The rapid tumor accumulation and normal tissue clearance of sdAbs might be ideal for use with (211)At, a 7.2-h half-life α-emitter, if appropriate labeling chemistry can be devised to trap (211)At in cancer cells after sdAb binding. This study evaluated two reagents, [(211)At]SAGMB and iso-[(211)At]SAGMB, for this purpose...
September 19, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29031195/ginsenoside-rg3-attenuates-cisplatin-resistance-in-lung-cancer-by-downregulating-pd-l1-and-resuming-immune
#2
Zhansheng Jiang, Yanfang Yang, Yinli Yang, Yu Zhang, Zhensong Yue, Zhanyu Pan, Xiubao Ren
Programmed death ligand 1 (PD-L1) as one the most important immune checkpoint was verified to involve in chemotherapy resistance in non-small cell lung cancer (NSCLC). Ginsenoside Rg3 is isolated from Chinese herb-Panax ginseng which is recognized to boost immune and has anti-cancer activity against a majority of carcinomas including NSCLC. In this study, we aim to identify whether Rg3 could attenuate the PD-L1 expression induced by resistance to cisplatin and draw out the underlying mechanisms of PD-L1 in this process...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29029111/short-term-and-mid-term-survival-in-bronchial-sleeve-resection-by-robotic-system-versus-thoracotomy-for-centrally-located-lung-cancer
#3
Chang Gu, Xufeng Pan, Yong Chen, Jun Yang, Heng Zhao, Jianxin Shi
OBJECTIVES: The aim of this study was to compare the short-term and mid-term results of patients with centrally located lung cancer who underwent bronchial sleeve resection by robotic system or thoracotomy. METHODS: From September 2014 to September 2015, 103 patients, including 17 robotic and 86 open cases, were included in our study. All the clinicopathological data, operative details and follow-up information were investigated. RESULTS: There were no intraoperative deaths...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029062/multicentric-evaluation-of-the-impact-of-central-tumour-location-when-comparing-rates-of-n1-upstaging-in-patients-undergoing-video-assisted-and-open-surgery-for-clinical-stage-i-non-small-cell-lung-cancer
#4
Herbert Decaluwé, René Horsleben Petersen, Alex Brunelli, Cecilia Pompili, Agathe Seguin-Givelet, Lucile Gust, Clemens Aigner, Pierre-Emmanuel Falcoz, Philippe Rinieri, Florian Augustin, Youri Sokolow, Ad Verhagen, Lieven Depypere, Kostas Papagiannopoulos, Dominique Gossot, Xavier Benoit D'Journo, Francesco Guerrera, Jean-Marc Baste, Thomas Schmid, Alessia Stanzi, Dirk Van Raemdonck, Jeremy Bardet, Pascal-Alexandre Thomas, Gilbert Massard, Steffen Fieuws, Johnny Moons, Christophe Dooms, Paul De Leyn, Henrik Jessen Hansen
OBJECTIVES: Large retrospective series have indicated lower rates of cN0 to pN1 nodal upstaging after video-assisted thoracic surgery (VATS) compared with open resections for Stage I non-small-cell lung cancer (NSCLC). The objective of our multicentre study was to investigate whether the presumed lower rate of N1 upstaging after VATS disappears after correction for central tumour location in a multivariable analysis. METHODS: Consecutive patients operated for PET-CT based clinical Stage I NSCLC were selected from prospectively managed surgical databases in 11 European centres...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029026/long-segment-pulmonary-artery-resection-to-avoid-pneumonectomy-long-term-results-after-prosthetic-replacement
#5
Antonio D'Andrilli, Giulio Maurizi, Anna Maria Ciccone, Claudio Andreetti, Mohsen Ibrahim, Cecilia Menna, Camilla Vanni, Federico Venuta, Erino A Rendina
OBJECTIVES: Resection of a long pulmonary artery (PA) segment infiltrated by tumour and reconstruction by conduit interposition or wide patch is a challenging but feasible option to avoid pneumonectomy. Our goal was to report the long-term results of our experience with this type of operation using various techniques and materials. METHODS: Between 1991 and 2015, 24 patients underwent sleeve resection of a long PA segment or extended resection (>2.5 cm) of 1 aspect of the circumference of the PA associated with lobectomy for centrally located lung cancer...
September 28, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029002/infrared-intraoperative-fluorescence-imaging-using-indocyanine-green-in-thoracic-surgery
#6
Olugbenga T Okusanya, Nicholas R Hess, James D Luketich, Inderpal S Sarkaria
Thoracic surgery faces many unique challenges that require innovative solutions. The increase in utilization of minimally invasive practices, poor overall cancer survival and significant morbidity of key operations remain key obstacles to overcome. Intraoperative fluorescence imaging is a process by which fluorescent dyes and imaging systems are used as adjuncts for surgeons in the operating room. Other surgical subspecialists have shown that intraoperative fluorescence imaging can be applied as a practical adjunct to their practices...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29028887/identification-of-cancer-driver-genes-in-focal-genomic-aberrations-from-whole-exome-sequencing-data
#7
Ho Jang, Hyunju Lee
Summary: Whole-exome sequencing (WES) data have been used for identifying copy number aberrations in cancer cells. Nonetheless, the use of WES is still challenging for identification of focal aberrant regions in multiple samples that may contain cancer driver genes. In this study, we developed a wavelet-based method for identifying focal genomic aberrant regions in the WES data from cancer cells (WIFA-X). When we applied WIFA-X to glioblastoma multiforme and lung adenocarcinoma datasets, WIFA-X outperformed other approaches on identifying cancer driver genes...
September 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028683/lung-cancer-associated-with-arsenic-ingestion-cell-type-specificity-and-dose-response
#8
Yau-Chang Kuo, Yu-Shing Lo, How-Ran Guo
BACKGROUND: Arsenic is a well-documented human carcinogen, and studies on urinary and skin cancers have shown that the carcinogenicity of ingested arsenic has cell-type specificity. To evaluate whether this is also true for lung cancers, we conducted a study on 243 townships in Taiwan. METHODS: The arsenic levels were assessed using measurement reports from a previous survey, and the incidence of lung cancer was assessed using the data gathered by the National Cancer Registry Program...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028642/-lost-to-follow-up-among-adult-cancer-survivors
#9
Amitoj Gill, Rohit Gosain, Shruti Bhandari, Rahul Gosain, Gurkirat Gill, Joseph Abraham, Kenneth Miller
BACKGROUND: Follow-up cancer care is important for patients who have received IV chemotherapy but some patients discontinue their care and are lost to follow-up (LFU) at the cancer center where they were treated. The purpose of this study was to determine what proportion of cancer survivors are LFU at 5 years after treatment, the timing of LFU, and the characteristics of those who do not continue survivorship care. METHODS: Adult patients with cancer who were treated with chemotherapy at a large community teaching hospital in 2006 and 2007 were identified and linked with State tumor registry data...
October 12, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29028534/discovery-of-benzo-g-quinazolin-benzenesulfonamide-derivatives-as-dual-egfr-her2-inhibitors
#10
Mansour S Alsaid, Abdullah A Al-Mishari, Aiten M Soliman, Fatma A Ragab, Mostafa M Ghorab
An array of some new N-(substituted)-2-((4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-yl)thio)acetamide 5-19 were synthesized from the starting compound 4-(2-mercapto-4-oxobenzo[g]quinazolin-3(4H)-yl)benzenesulfonamide 4, to be assessed for their cytotoxic activity against A549 lung cancer cell line and to determine their inhibitory effect on EGFR tyrosine kinase enzyme. Compounds 5-19 showed high activity towards A549 cell line with IC50 values of 0.12-8.70 μM. Compounds 6, 12 and 18 were the most potent in this series...
September 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#11
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29028092/long-non-coding-rna-ror-is-a-novel-prognosis-factor-associated-with-non-small-cell-lung-cancer-progression
#12
C-H Qu, Q-Y Sun, F-M Zhang, Y-M Jia
OBJECTIVE: The aim of the present study was to determine the expression levels of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) in non-small-cell lung cancer (NSCLC) patients and to further explore the prognostic value of this lncRNA. PATIENTS AND METHODS: In our investigation, we determined the expression of linc-ROR in human NSCLC tissues and matched normal lung tissues by quantitative Real-time-PCR analysis. Also, correlations between linc-ROR expression and the clinicopathological features were evaluated...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028091/investigation-of-serum-mir-411-as-a-diagnosis-and-prognosis-biomarker-for-non-small-cell-lung-cancer
#13
S-Y Wang, Y Li, Y-S Jiang, R-Z Li
OBJECTIVE: Biomarkers in blood have become increasingly appreciated in the diagnosis and prognosis of non-small cell lung cancer (NSCLC). The purpose of the current study was to explore potential diagnostic and prognostic value of serum miR-411 in NSCLC patients. PATIENTS AND METHODS: 153 patients with NSCLC and 75 healthy controls were enrolled in the study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to determine the expression level of serum miR-411 in NSCLC patients and healthy controls...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028090/a-comparative-study-on-inflammatory-factors-and-immune-functions-of-lung-cancer-and-pulmonary-ground-glass-attenuation
#14
C-Y Liu, W-G Xie, S Wu, J-W Tian, J Li
OBJECTIVE: To compare the inflammatory factors and immune functions of patients with lung cancer and pulmonary ground-glass attenuation. PATIENTS AND METHODS: A total of 108 patients with pulmonary sarcoidosis treated in our hospital were selected and randomly divided into lung cancer group (Group A, n=32), diffuse ground-glass nodule group (Group B, n=35) and solitary ground-glass nodule group (Group C, n=41) according to the diagnosis results. Levels of inflammatory factors, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10), in serum were detected via enzyme-linked immunosorbent assay (ELISA); the T-lymphocyte subset levels (CD3+, CD4+, CD8+ and CD4+/CD8+) in the immune system of patients in the three groups were detected using the flow cytometer; the levels of immunoglobulins, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM), were detected via immunoturbidimetric assay...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028089/the-productions-of-atrial-natriuretic-peptide-and-arginine-vasopressin-in-small-cell-lung-cancer-with-brain-metastases-and-their-associations-with-hyponatremia
#15
N-H Sun, S-H Wang, J-N Liu, A Liu, W-J Gong, Y Liu, P Sun, H Li
OBJECTIVE: Hyponatremia is one of the most frequently encountered electrolyte disorder in small cell lung cancer (SCLC) patients. It was shown that some SCLC cell lines could produce atrial natriuretic peptide (ANP) and arginine vasopressin (AVP). The aim of the study was to assess the secretion of ANP, AVP and their relative contributions to hyponatremia in SCLC patients, especially in patients with brain metastases. PATIENTS AND METHODS: In total, 194 SCLC patients including 51 patients with brain metastases were collected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028088/antitumor-effect-of-mir-27b-3p-on-lung-cancer-cells-via-targeting-fzd7
#16
Y Sun, T Xu, Y-W Cao, X-Q Ding
OBJECTIVE:   Lung cancer is the most common malignancy with the highest mortality rate among cancers. microRNAs (miRNAs) have been confirmed to be closely related to the physiological disorder, especially the tumor process. This study aimed to investigate the effect of miR-27b-3p on lung tumor cells. MATERIALS AND METHODS: The expressions of miR-27b-3p in lung tumors and adjacent non-tumors lung tissues were compared. We test the bonding effect of miR-27b-3p on the Fzd7 promoter, and miR-27b-3p effects on the Fzd7 expression in both NCI-H446 and A549 cells...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027754/afatinib-treatment-of-a-squamous-lung-cancer-after-tumor-progression-of-nivolumab
#17
Yinghua Jin, Qiuying Jiang, Tao Xin
Nivolumab prolonged disease control in a patient with advanced squamous lung cancer that was refractory to multiple treatments. The rapid eradication of cancer after the administration of nivolumab caused hemoptysis and repeated infection. Six months after immunotherapy, mediastinal lymph node metastasis developed and afatinib effectively relieved dysphonia associated with nerve paralysis.
October 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29027179/association-of-dnmt3b-283t-c-polymorphism-with-risk-of-lung-and-gastric-cancer-a-case-control-study-and-a-meta-analysis
#18
Xianhong Feng, Jingdong Wang, Xiuli Gu, Jingli Zhang, Xiaolin Li, Zhi Tao, Jiebing Chen, Bifeng Chen
PURPOSE: To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis. METHODS: The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing. RESULTS: The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding...
October 12, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29027110/predicting-the-cancer-burden-in-catalonia-between-2015-and-2025-the-challenge-of-cancer-management-in-the-elderly
#19
R Clèries, A Ameijide, R Marcos-Gragera, L Pareja, M Carulla, M-L Vilardell, L Esteban, M Buxó, J-A Espinàs, A Puigdefàbregas, J Ribes, A Izquierdo, J Galceran, J M Borrás
BACKGROUND: Developing effective cancer control programmes requires information on the future cancer burden in an ageing population. In our study we predicted the burden of cancer in Catalonia from 2015 to 2025. METHODS: Bayesian age-period-cohort models were used to predict the burden of cancer from 2015 to 2025 using incidence data from the Girona and Tarragona cancer registries and cancer mortality data from the Catalan mortality registry. Using the Bashir-Estève method, we divided the net change in the number of cases between 2015 and 2025 into changes due to population size (S), cancer risk (R) and age (A) distribution...
October 12, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29027085/two-new-cytotoxic-stilbenoid-dimers-isolated-from-cajanus-cajan
#20
Nenling Zhang, Xiangchun Shen, Xiaofei Jiang, Jiazhong Cai, Xiaoling Shen, Yingjie Hu, Samuel X Qiu
Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC50 values: 2...
October 12, 2017: Journal of Natural Medicines
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