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https://www.readbyqxmd.com/read/30242906/ccdc85b-promotes-non-small-cell-lung-cancer-cell-proliferation-and-invasion
#1
Yangyang Feng, Yue Gao, Juanhan Yu, Guiyang Jiang, Xiupeng Zhang, Xuyong Lin, Qiang Han, Xuezhu Rong, Hongtao Xu, Qingchang Li, Xueshan Qiu, Enhua Wang
Coiled-coil domain containing 85 B (CCDC85B) is involved in diverse biological processes; however, its expression patterns and functions in human cancers are yet unknown. The present study demonstrated that the expression of CCDC85B in the cytoplasm of the non-small cell lung cancer (NSCLC) tumor cells was significantly higher compared to adjacent normal lung tissues (P < 0.05). Furthermore, CCDC85B expression correlated with advanced TNM stage (P = 0.004) and positive regional lymph node metastasis (P = 0...
September 22, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/30242869/association-of-single-nucleotide-autophagy-related-protein-5-gene-polymorphism-rs2245214-with-susceptibility-to-non-small-cell-lung-cancer
#2
Mohsen Nikseresht, Maryam Shahverdi, Mehdi Dehghani, Hassan Abidi, Reza Mahmoudi, Ghasem Ghalamfarsa, Leila Manzouri, Saeid Ghavami
Autophagy is a mechanism that is involved in the regulation of cellular life, apoptosis, and stemness while its intervening genes play important functions in various cancers including lung cancer. ATG5 is one of the key genes for the regulation of the autophagy pathway. In this study, our team has investigated the potential relationship between ATG5 gene polymorphism rs2245214 with non-small cell lung cancer (NSCLC) in a subpopulation of patients from southern Iran. In this study, 34 patients with NSCLC (20 males and 14 females [mean age: 12...
September 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30242476/tumor-specific-genetic-aberrations-in-cell-free-dna-of-gastroesophageal-cancer-patients
#3
REVIEW
Kristina Magaard Koldby, Michael Bau Mortensen, Sönke Detlefsen, Per Pfeiffer, Mads Thomassen, Torben A Kruse
The applicability of liquid biopsies is studied intensively in all types of cancer and analysis of circulating tumor DNA (ctDNA) has recently been implemented clinically for mutation detection in lung cancer. ctDNA may provide information about tumor quantity and mutations present in the tumor, and as such have many potential applications in diagnosis and treatment of cancer. It has been suggested that ctDNA analysis may overcome the issue of intra-tumor heterogeneity faced by tissue biopsies and serve as an additional diagnostic tool...
September 21, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30242135/hypoxia-inducible-factor-1-dependent-expression-of-adenosine-receptor-2b-promotes-breast-cancer-stem-cell-enrichment
#4
Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, Gregg L Semenza
Breast cancer stem cells (BCSCs), which are characterized by a capacity for unlimited self-renewal and for generation of the bulk cancer cell population, play a critical role in cancer relapse and metastasis. Hypoxia is a common feature of the cancer microenvironment that stimulates the specification and maintenance of BCSCs. In this study, we found that hypoxia increased expression of adenosine receptor 2B (A2BR) in human breast cancer cells through the transcriptional activity of hypoxia-inducible factor 1...
September 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30241789/external-validation-of-an-ntcp-model-for-acute-esophageal-toxicity-in-locally-advanced-nsclc-patients-treated-with-intensity-modulated-chemo-radiotherapy
#5
Frank J W M Dankers, Robin Wijsman, Esther G C Troost, Caroline J A Tissing-Tan, Margriet H Kwint, José Belderbos, Dirk de Ruysscher, Lizza E Hendriks, Lioe-Fee de Geus-Oei, Laura Rodwell, Andre Dekker, René Monshouwer, Aswin L Hoffmann, Johan Bussink
BACKGROUND AND PURPOSE: We externally validated a previously established multivariable normal-tissue complication probability (NTCP) model for Grade ≥2 acute esophageal toxicity (AET) after intensity-modulated (chemo-)radiotherapy or volumetric-modulated arc therapy for locally advanced non-small cell lung cancer. MATERIALS AND METHODS: A total of 603 patients from five cohorts (A-E) within four different Dutch institutes were included. Using the NTCP model, containing predictors concurrent chemoradiotherapy, mean esophageal dose, gender and clinical tumor stage, the risk of Grade ≥2 AET was estimated per patient and model discrimination and (re)calibration performance were evaluated...
September 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30241463/overlapping-group-screening-for-detection-of-gene-gene-interactions-application-to-gene-expression-profiles-with-survival-trait
#6
Jie-Huei Wang, Yi-Hau Chen
BACKGROUND: The development of a disease is a complex process that may result from joint effects of multiple genes. In this article, we propose the overlapping group screening (OGS) approach to determining active genes and gene-gene interactions incorporating prior pathway information. The OGS method is developed to overcome the challenges in genome-wide data analysis that the number of the genes and gene-gene interactions is far greater than the sample size, and the pathways generally overlap with one another...
September 21, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/30241276/stage-iii-non-small-cell-lung-cancer-treated-with-concurrent-chemoradiation-followed-or-not-by-consolidation-chemotherapy-a-survival-analysis-from-a-brazilian-multicentric-cohort
#7
Vladmir C Cordeiro de Lima, Clarissa S Baldotto, Carlos H Barrios, Eldsamira M Sobrinho, Mauro Zukin, Clarissa Mathias, Facundo Zaffaroni, Rodrigo C Nery, Gabriel Madeira, Alex V Amadio, Juliano C Coelho, Guilherme Geib, Maria Fernanda Simões, Gilberto Castro
PURPOSE: Of newly diagnosed patients with non-small-cell lung cancer (NSCLC), stage III accounts for 30%. Most patients are treated with concurrent chemoradiation therapy, but the addition of consolidation chemotherapy (CC) is debatable. We examined the effect of CC in Brazilian patients with stage III NSCLC treated in routine clinical practice. METHODS: We retrospectively collected data for patients from five different Brazilian cancer institutions who had stage III NSCLC and who were treated with chemoradiation therapy followed or not by CC...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241269/data-reliability-and-coding-completeness-of-cancer-registry-information-using-reabstracting-method-in-the-national-cancer-institute-thailand-2012-to-2014
#8
Anupong Sirirungreung, Rangsiya Buasom, Chuleeporn Jiraphongsa, Suleeporn Sangrajrang
PURPOSE: Data quality is a core value of cancer registries, which bring about greater understanding of cancer distribution and determinants. Thailand established its cancer registry in 1986; however, studies focusing on data reliability have been limited. This study aimed to assess the coding completeness and reliability of the National Cancer Institute (NCI) hospital-based cancer registry, Thailand. METHODS: This study was conducted using the reabstracting method...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241268/disparities-in-breast-lung-and-cervical-cancer-trials-worldwide
#9
Ramya Ramaswami, Eduardo Paulino, Adriana Barrichello, Angelica Nogueira-Rodrigues, Alexandra Bukowski, Jessica St Louis, Paul E Goss
PURPOSE: As cancer burden has risen worldwide, physicians, patients, and their advocates have become aware that the clinical cancer trial research paradigm is not ubiquitous. Furthermore, the number and characteristics of trials that are registered in low- and middle-income countries (LMICs) compared with that in high-income countries (HICs) are unknown. METHODS: We collected retrospective data on trials for breast, lung, and cervical cancer registered in ClinicalTrials...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241263/cost-of-oncology-drugs-in-the-middle-eastern-country-of-lebanon-an-update-2014-2016
#10
Fadia Elias, Ibrahim R Bou-Orm, Salim M Adib, Selim Gebran, Anthony Gebran, Walid Ammar
PURPOSE: This study aims to evaluate trends in the increasing costs of oncology drugs procured by the Lebanese Ministry of Public Health (MOPH) between 2014 and 2016 and to assess the impact of the introduction in mid-2015 of new immunotherapy drugs for the treatment of lung cancer on the overall and specific costs of that treatment. METHODS: A secondary analysis of data from the MOPH Cancer Drug Scientific Committee data base was conducted using a total of 18,133 cancer files between 2014 and 2016...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241262/estimates-of-cancer-incidence-in-ethiopia-in-2015-using-population-based-registry-data
#11
Solomon Tessema Memirie, Mahlet Kifle Habtemariam, Mathewos Asefa, Biniyam Tefera Deressa, Getamesay Abayneh, Biniam Tsegaye, Mihiret Woldetinsae Abraha, Girma Ababi, Ahmedin Jemal, Timothy R Rebbeck, Stéphane Verguet
PURPOSE: Noncommunicable diseases, prominently cancer, have become the second leading cause of death in the adult population of Ethiopia. A population-based cancer registry has been used in Addis Ababa (the capital city) since 2011. Availability of up-to-date estimates on cancer incidence is important in guiding the national cancer control program in Ethiopia. METHODS: We obtained primary data on 8,539 patients from the Addis Ababa population-based cancer registry and supplemented by data on 1,648 cancer cases collected from six Ethiopian regions...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241252/challenges-in-lung-cancer-screening-in-latin-america
#12
Luis E Raez, Amanda Nogueira, Edgardo S Santos, Ricardo Sales Dos Santos, Juliana Franceschini, David Arias Ron, Mark Block, Nise Yamaguchi, Christian Rolfo
Lung cancer is the deadliest cancer worldwide and is of particular concern for Latin America. Its rising incidence in this area of the world poses myriad challenges for the region's economies, which are already struggling with limited resources to meet the health care needs of low- and middle-income populations. In this environment, we are concerned that regional governments are relatively unaware of the pressing need to implement effective strategies for the near future. Low-dose chest computed tomography (LDCT) for screening, and routine use of minimally invasive techniques for diagnosis and staging remain uncommon...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241240/outcomes-in-treatment-na%C3%A3-ve-patients-with-metastatic-extremity-osteosarcoma-treated-with-ogs-12-a-novel-non-high-dose-methotrexate-based-dose-dense-combination-chemotherapy-in-a-tertiary-care-cancer-center
#13
Jyoti Bajpai, Arun Chandrasekharan, Vijai Simha, Vikas Talreja, Ashay Karpe, Nikihil Pandey, Ashish Singh, Bharat Rekhi, Tushar Vora, Jaya Ghosh, Shripad Banavali, Sudeep Gupta
PURPOSE: Metastatic osteosarcoma is largely treated with high-dose methotrexate (HDMTX)-based therapy, especially in the pediatric population. This mandates complex pharmacokinetic monitoring in a costly inpatient setting to mitigate unpredictable serious toxicities. Hence, a non-HDMTX-based regimen is worth exploring, especially in India and low- and middle-income countries. MATERIALS AND METHODS: All consecutive treatment-naïve patients with metastatic osteosarcoma were prospectively treated on the novel OGS-12 protocol consisting of sequential doublets of doxorubicin, cisplatin, and ifosfamide...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241213/screening-for-lung-cancer-has-limited-effectiveness-globally-and-distracts-from-much-needed-efforts-to-reduce-the-critical-worldwide-prevalence-of-smoking-and-related-morbidity-and-mortality
#14
Cherian Verghese, Cristina Redko, Brian Fink
No abstract text is available yet for this article.
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241202/prophylactic-cranial-irradiation-for-extensive-stage-small-cell-lung-cancer-a-retrospective-analysis
#15
Adriana Matutino, Milena P Mak, Tiago K Takahashi, Rafael C Bitton, Denyei Nakazato, Natalia M P Fraile, Roger G R Guimarães, Flávia C G Gabrielli, Karina G M C Vasconcelos, Heloísa de A Carvalho, Gilberto de Castro
PURPOSE: Extensive-stage small-cell lung cancer (esSCLC) is an incurable disease and represents a therapeutic challenge because of its poor prognosis. Studies in prophylactic cranial irradiation (PCI) in esSCLC have shown a decreased incidence of symptomatic brain metastases in patients who respond to systemic chemotherapy. However, its effect on overall survival is debatable. We evaluated the benefit of PCI in patients with esSCLC in terms of overall survival, progression-free survival, incidence of brain metastases, recurrence rate, and exposure to postrecurrence therapies...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30241030/combination-antitumor-immunotherapy-with-vegf-and-pigf-sirna-via-systemic-delivery-of-multi-functionalized-nanoparticles-to-tumor-associated-macrophages-and-breast-cancer-cells
#16
Yudong Song, Cui Tang, Chunhua Yin
Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2-TAMs) within tumor microenvironment (TME), work synergistically and independently in mediating tumor progression and immunosuppression, combinatorial immune-based approaches targeting them are expected to be a potent therapeutic modality for patients. Here, polyethylene glycol (PEG) and mannose doubly modified trimethyl chitosan (PEG = MT) along with citraconic anhydride grafted poly (allylamine hydrochloride) (PC)-based nanoparticles (NPs) (PEG = MT/PC NPs) with dual pH-responsiveness were developed to deliver VEGF siRNA (siVEGF)/PIGF siRNA (siPIGF) to both M2-TAMs and breast cancer cells for antitumor immunotherapy...
September 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/30240852/osimertinib-versus-standard-of-care-egfr-tki-as-first-line-treatment-in-patients-with-egfrm-advanced-nsclc-flaura-asian-subset
#17
Byoung Chul Cho, Busayamas Chewaskulyong, Ki Hyeong Lee, Arunee Dechaphunkul, Virote Sriuranpong, Fumio Imamura, Naoyuki Nogami, Takayasu Kurata, Isamu Okamoto, Caicun Zhou, Ying Cheng, Eun Kyung Cho, Pei Jye Voon, Jong-Seok Lee, Helen Mann, Matilde Saggese, Thanyanan Reungwetwattana, Suresh S Ramalingam, Yuichiro Ohe
INTRODUCTION: Here we report efficacy and safety data of an Asian subset of the Phase III FLAURA trial (NCT02296125), which compares osimertinib with standard-of-care (SoC) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in patients with previously untreated advanced non-small cell lung cancer (NSCLC) with tumors harboring exon 19 deletion (Ex19del)/L858R EGFR-TKI sensitizing mutations (EGFRm). METHODS: Eligible Asian patients (enrolled at Asian sites) ≥18 years (≥20 years in Japan), with untreated EGFRm advanced NSCLC were randomized 1:1 to receive osimertinib (80 mg orally, once daily [qd]) or SoC EGFR-TKI (gefitinib [250 mg] or erlotinib [150 mg] orally, qd)...
September 18, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/30240635/roles-of-dna-repair-enzyme-ogg1-in-innate-immunity-and-its-significance-for-lung-cancer
#18
REVIEW
Spiros Vlahopoulos, Maria Adamaki, Nikolas Khoury, Vassilis Zoumpourlis, Istvan Boldogh
Cytokines are pivotal mediators of the immune response, and their coordinated expression protects host tissue from excessive damage and oxidant stress. Nevertheless, the development of lung pathology, including asthma, chronic obstructive pulmonary disease, and ozone-induced lung injury, is associated with oxidant stress; as evidence, there is a significant increase in levels of the modified guanine base 7,8-dihydro-8-oxoguanine (8-oxoG) in the genome. 8-OxoG is primarily recognized by 8-oxoguanine glycosylase 1 (OGG1), which catalyzes the first step in the DNA base excision repair pathway...
September 18, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30240634/roles-of-dna-repair-enzyme-ogg1-in-innate-immunity-and-its-significance-for-lung-cancer
#19
REVIEW
Spiros Vlahopoulos, Maria Adamaki, Nikolas Khoury, Vassilis Zoumpourlis, Istvan Boldogh
Cytokines are pivotal mediators of the immune response, and their coordinated expression protects host tissue from excessive damage and oxidant stress. Nevertheless, the development of lung pathology, including asthma, chronic obstructive pulmonary disease, and ozone-induced lung injury, is associated with oxidant stress; as evidence, there is a significant increase in levels of the modified guanine base 7,8-dihydro-8-oxoguanine (8-oxoG) in the genome. 8-OxoG is primarily recognized by 8-oxoguanine glycosylase 1 (OGG1), which catalyzes the first step in the DNA base excision repair pathway...
September 18, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30240186/ptml-combinatorial-model-of-chembl-compounds-assays-for-multiple-types-of-cancer
#20
Harbil Bediaga, Sonia Arrasate, Humbert González-Díaz
Determining the target proteins of new anti-cancer compounds is a very important task in Medicinal Chemistry. In this sense, chemists carry out preclinical assays with a high number of combinations of experimental conditions (cj). In fact, ChEMBL database contains outcomes of 65534 different anticancer activity preclinical assays for 35565 different chemical compounds (1.84 assays per compound). These assays cover different combinations of cj formed from >70 different biological activity parameters (c0), >300 different drug targets (c1), >230 cell lines (c2), and 5 organisms of assay (c3) and/or organisms of the target (c4)...
September 21, 2018: ACS Combinatorial Science
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