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Laura A Kresty, Susan R Mallery, Gary D Stoner
BACKGROUND: Black raspberries (BRB) inhibit a broad range of cancers in preclinical models, including in vivo models of oral, esophageal, colon, breast and skin cancer. Promising preclinical results have led to clinical evaluations in cancer patients or patients at increased risk for cancer development. OBJECTIVE: To summarize clinical investigations targeting cancer or precancerous lesions with BRB and discuss future directions. METHODS: A thorough literature search was conducted through December 1, 2015 to identify all published studies evaluating BRB in cancer focused clinical trials...
2016: Journal of Berry Research
Laura A Kresty, John J Fromkes, Wendy L Frankel, Cynthia D Hammond, Navindra P Seeram, Maureen Baird, Gary D Stoner
Black raspberries inhibit a broad range of cancers in preclinical models which has led to clinical evaluations targeting premalignant lesions of the colon, oral cavity and esophagus. A phase I pilot study was conducted in twenty Barrett's esophagus (BE) patients to investigate the effect of lyophilized black raspberries (LBR) on urinary metabolites and markers of lipid peroxidation, DNA damage and tissue markers of cellular proliferation, detoxification, and inflammation. Surveys, biopsies, blood and urine samples were collected before and after 6 months of LBR treatment (32 or 45 g)...
July 7, 2016: Oncotarget
Paul Scholz, Julia Mohrhardt, Fabian Jansen, Benjamin Kalbe, Claudia Haering, Katharina Klasen, Hanns Hatt, Sabrina Osterloh
It is generally agreed that in olfactory sensory neurons (OSNs), the binding of odorant molecules to their specific olfactory receptor (OR) triggers a cAMP-dependent signaling cascade, activating cyclic-nucleotide gated (CNG) channels. However, considerable controversy dating back more than 20 years has surrounded the question of whether alternate signaling plays a role in mammalian olfactory transduction. In this study, we demonstrate a specific alternate signaling pathway in Olfr73-expressing OSNs. Methylisoeugenol (MIEG) and at least one other known weak Olfr73 agonist (Raspberry Ketone) trigger a signaling cascade independent from the canonical pathway, leading to the depolarization of the cell...
2016: Frontiers in Cellular Neuroscience
James L McDonagh, Daniel Barker, Rosanna G Alderson
BACKGROUND: The increasing use of computers in science allows for the scientific analyses of large datasets at an increasing pace. We provided examples and interactive demonstrations at Dundee Science Centre as part of the 2015 Women in Science festival, to present aspects of computational science to the general public. We used low-cost Raspberry Pi computers to provide hands on experience in computer programming and demonstrated the application of computers to biology. Computer games were used as a means to introduce computers to younger visitors...
2016: SpringerPlus
Jordi Sapes, Francesc Solsona
Nowadays, researchers are paying increasing attention to embedding systems. Cost reduction has lead to an increase in the number of platforms supporting the operating system Linux, jointly with the Raspberry Pi motherboard. Thus, embedding devices on Raspberry-Linux systems is a goal in order to make competitive commercial products. This paper presents a low-cost fingerprint recognition system embedded into a Raspberry Pi with Linux.
2016: Sensors
James F Robson, Daniel Barker
BACKGROUND: To demonstrate the bioinformatics capabilities of a low-cost computer, the Raspberry Pi, we present a comparison of the protein-coding gene content of two species in phylum Chlamydiae: Chlamydia trachomatis, a common sexually transmitted infection of humans, and Candidatus Protochlamydia amoebophila, a recently discovered amoebal endosymbiont. Identifying species-specific proteins and differences in protein families could provide insights into the unique phenotypes of the two species...
2015: BMC Research Notes
Thorsten Probst, Arno Rehn, Martin Koch
We present a terahertz quasi time domain spectroscopy (QTDS) system setup which is improved regarding cost and compactness. The diode laser is mounted directly onto the optical delay line, making the optical setup more compact. The system is operated using a Raspberry Pi and an additional sound card. This combination replaces the desktop/laptop computer, the lock-in-amplifier, the stage controller and the signal generator. We examined not only a commercially available stepper motor driven delay line, but also the repurposed internal mechanics from a DVD drive...
August 24, 2015: Optics Express
Matthew Tivnan, Rajan Gurjar, David E Wolf, Karthik Vishwanath
Diffuse Correlation Spectroscopy (DCS) is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive...
2015: Sensors
Dominik Kopczynski, Sven Rahmann
Ion mobility (IM) spectrometry (IMS), coupled with multi-capillary columns (MCCs), has been gaining importance for biotechnological and medical applications because of its ability to detect and quantify volatile organic compounds (VOC) at low concentrations in the air or in exhaled breath at ambient pressure and temperature. Ongoing miniaturization of spectrometers creates the need for reliable data analysis on-the-fly in small embedded low-power devices. We present the first fully automated online peak extraction method for MCC/IMS measurements consisting of several thousand individual spectra...
2015: Algorithms for Molecular Biology: AMB
D Parsons, J Robar
PURPOSE: The focus of this work is the development of a novel blade collimation system enabling volume-of-interest (VOI) CBCT using the kV source on a TrueBeam linear accelerator (linac). Advantages of the system are assessed, particularly with regard to reduction and localization of dose, as well as improvement of image quality. METHODS: A four blade dynamic kV collimator was developed to track a VOI during a CBCT acquisition. The system is controlled using a Raspberry Pi computer placed within the linac gantry...
June 2015: Medical Physics
Endre T Somogyi, Jean-Marie Bouteiller, James A Glazier, Matthias König, J Kyle Medley, Maciej H Swat, Herbert M Sauro
MOTIVATION: This article presents libRoadRunner, an extensible, high-performance, cross-platform, open-source software library for the simulation and analysis of models expressed using Systems Biology Markup Language (SBML). SBML is the most widely used standard for representing dynamic networks, especially biochemical networks. libRoadRunner is fast enough to support large-scale problems such as tissue models, studies that require large numbers of repeated runs and interactive simulations...
October 15, 2015: Bioinformatics
Manuel Caldas-Morgan, Alexander Alvarez-Rosario, Linilson Rodrigues Padovese
As industrial activities continue to grow on the Brazilian coast, underwater sound measurements are becoming of great scientific importance as they are essential to evaluate the impact of these activities on local ecosystems. In this context, the use of commercial underwater recorders is not always the most feasible alternative, due to their high cost and lack of flexibility. Design and construction of more affordable alternatives from scratch can become complex because it requires profound knowledge in areas such as electronics and low-level programming...
2015: PloS One
Hyunnho Cho, Hana Jung, Heejae Lee, Hae Chang Yi, Ho-kyung Kwak, Keum Taek Hwang
Black raspberry (BRB) seeds are a major waste product after fruit processing. The seeds are abundant in ellagitannins (ET), a class of hydrolysable tannins, which are hydrolyzed to ellagic acid (EA) and further metabolized to urolithin A (UA) and urolithin B (UB), known to be bioavailable in the colon and the prostate. In this study, the anti-cancer activities of these compounds were evaluated on HT-29 colon cancer cells. ET, EA, UA and UB inhibited the proliferation of the cancer cells. EA caused a slight, but significant cell cycle arrest at the G1 phase, and urolithins caused cell cycle arrest at the G2/M phase and upregulated p21 expression...
May 2015: Food & Function
Ádám Z Lendvai, Çağlar Akçay, Talia Weiss, Mark F Haussmann, Ignacio T Moore, Frances Bonier
Playbacks of visual or audio stimuli to wild animals is a widely used experimental tool in behavioral ecology. In many cases, however, playback experiments are constrained by observer limitations such as the time observers can be present, or the accuracy of observation. These problems are particularly apparent when playbacks are triggered by specific events, such as performing a specific behavior, or are targeted to specific individuals. We developed a low-cost automated playback/recording system, using two field-deployable devices: radio-frequency identification (RFID) readers and Raspberry Pi micro-computers...
2015: PeerJ
F Arnold, I DeMallie, L Florence, D O Kashinski
This manuscript addresses the design, hardware details, construction, and programming of an apparatus allowing an experimenter to monitor and record high-temperature thermocouple measurements of dynamic systems in real time. The apparatus uses wireless network technology to bridge the gap between a dynamic (moving) sample frame and the static laboratory frame. Our design is a custom solution applied to samples that rotate through large angular displacements where hard-wired and typical slip-ring solutions are not practical because of noise considerations...
March 2015: Review of Scientific Instruments
Andre Pereira, Mostafa Atri, Patrik Rogalla, Thien Huynh, Martin E O'Malley
PURPOSE: The value of a teaching case repository in radiology training programs is immense. The allocation of resources for putting one together is a complex issue, given the factors that have to be coordinated: hardware, software, infrastructure, administration, and ethics. Costs may be significant and cost-effective solutions are desirable. METHODS: We chose Medical Imaging Resource Center (MIRC) to build our teaching file. It is offered by RSNA for free. For the hardware, we chose the Raspberry Pi, developed by the Raspberry Foundation: a small control board developed as a low cost computer for schools also used in alternative projects such as robotics and environmental data collection...
November 2015: International Journal of Computer Assisted Radiology and Surgery
Pawel L Urban
This minireview discusses universal electronic modules (generic programmable units) and their use by analytical chemists to construct inexpensive, miniature or automated devices. Recently, open-source platforms have gained considerable popularity among tech-savvy chemists because their implementation often does not require expert knowledge and investment of funds. Thus, chemistry students and researchers can easily start implementing them after a few hours of reading tutorials and trial-and-error. Single-board microcontrollers and micro-computers such as Arduino, Teensy, Raspberry Pi or BeagleBone enable collecting experimental data with high precision as well as efficient control of electric potentials and actuation of mechanical systems...
February 21, 2015: Analyst
Fabio Leccese, Marco Cagnetti, Daniele Trinca
A smart city application has been realized and tested. It is a fully remote controlled isle of lamp posts based on new technologies. It has been designed and organized in different hierarchical layers, which perform local activities to physically control the lamp posts and transmit information with another for remote control. Locally, each lamp post uses an electronic card for management and a ZigBee tlc network transmits data to a central control unit, which manages the whole isle. The central unit is realized with a Raspberry-Pi control card due to its good computing performance at very low price...
2014: Sensors
Fabio Leccese, Marco Cagnetti, Andrea Calogero, Daniele Trinca, Stefano di Pasquale, Sabino Giarnetti, Lorenzo Cozzella
A new acquisition system for remote control of wall paintings has been realized and tested in the field. The system measures temperature and atmospheric pressure in an archeological site where a fresco has been put under control. The measuring chain has been designed to be used in unfavorable environments where neither electric power nor telecommunication infrastructures are available. The environmental parameters obtained from the local monitoring are then transferred remotely allowing an easier management by experts in the field of conservation of cultural heritage...
2014: Sensors
Aleksandar Nikodijevic, Patrick Pichler, Mathias Forjan, Stefan Sauermann
In the daily routine of hospitals, which work with paper based medical records, the staff has to find the appropriate patient file if it needs information about the patient. With the introduction of ELGA the Austrian hospitals have to use specific standards for their clinical documentation. These structured documents can be used to feed an e-Ink reader with information about every patient in a hospital. Combined with RFID and security measures, the clinical staff is supported during the patient file searching process...
2014: Studies in Health Technology and Informatics
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