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Atherosclerosis in carotid arteries

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https://www.readbyqxmd.com/read/28211187/deletion-of-junctional-adhesion-molecule-a-from-platelets-increases-early-stage-neointima-formation-after-wire-injury-in-hyperlipidemic-mice
#1
Zhen Zhao, Tanja Vajen, Ela Karshovska, Annemiek Dickhout, Martin M Schmitt, Remco T A Megens, Philipp von Hundelshausen, Thomas A Koeppel, Tilman M Hackeng, Christian Weber, Rory R Koenen
Platelets play an important role in the pathogenesis of vascular remodelling after injury. Junctional adhesion molecule A (JAM-A) was recently described to regulate platelet activation. Specific deletion of JAM-A from platelets resulted in increased reactivity and in accelerated progression of atherosclerosis. The aim of this study was to investigate the specific contribution of platelet-derived JAM-A to neointima formation after vascular injury. Mice with or without platelet-specific (tr)JAM-A-deficiency in an apolipoprotein e (apoe(-/-) ) background underwent wire-induced injury of the common carotid artery...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28208842/assessment-of-serum-vaspin-levels-among-type-2-diabetes-mellitus-patients-with-or-without-acute-coronary-syndrome
#2
Aswathy Jaya Sathyaseelan, Prashant Shankarrao Adole, Mukta Wyawahare, Rama Prakasha Saya
INTRODUCTION: Type 2 Diabetes Mellitus (DM) is on the verge of becoming a pandemic in India. Type 2 DM patient have two to four times increased risk of carotid artery disease. Adipokines have been regarded recently as direct link between diabetes and atherosclerosis. Visceral Adipose Tissue Derived Serine Protease Inhibitor (VASPIN); one of the most recently discovered adipokine, inhibits the proteases responsible for insulin resistance, carotid plaque development and rupture. In literature, few studies have addressed the role of VASPIN in pathogenesis of Acute Coronary Syndrome (ACS) in patients with type 2 DM...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28202852/association-of-serum-uric-acid-levels-with-leg-ischemia-in-patients-with-peripheral-arterial-disease-after-treatment
#3
Yoko Sotoda, Shigeki Hirooka, Hiroyuki Orita, Ichiro Wakabayashi
AIM: We investigated the relationships of serum uric acid levels with the progression of atherosclerosis in patients with peripheral arterial disease (PAD) after treatment. METHODS: Subjects were male patients diagnosed with PAD. Atherosclerosis at the common carotid artery was evaluated based on its intima-media thickness (IMT). Leg arterial flow was evaluated by measuring ankle-brachial index (ABI) and exercise-induced decrease in ABI. RESULTS: Among various risk factors including age, blood pressure, adiposity, estimated glomerular filtration rate, and blood lipid, blood glucose, uric acid, fibrinogen and C-reactive protein levels, only uric acid levels showed significant correlations with ABI [Pearson's correlation coefficient, -0...
February 15, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28199691/association-of-macrophage-inflammation-biomarkers-with-progression-of-subclinical-carotid-artery-atherosclerosis-in-hiv-infected-women-and-men
#4
David B Hanna, Juan Lin, Wendy S Post, Howard N Hodis, Xiaonan Xue, Kathryn Anastos, Mardge H Cohen, Stephen J Gange, Sabina A Haberlen, Sonya L Heath, Jason M Lazar, Chenglong Liu, Wendy J Mack, Igho Ofotokun, Frank J Palella, Phyllis C Tien, Mallory D Witt, Alan L Landay, Lawrence A Kingsley, Russell P Tracy, Robert C Kaplan
No abstract text is available yet for this article.
February 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28198536/prevalence-of-risk-factors-and-asymptomatic-carotid-atherosclerosis-in-diabetic-patients-screened-for-silent-myocardial-ischemia-by-spect-myocardial-imaging
#5
Irena Peovska Mitevska, Natalija Baneva, Marijan Bosevski, Elizabeta Srbinovska Kostovska
BACKGROUND: The aim of the study was to evaluate whether there is any association between myocardial ischemia, common risk factors and carotid artery ultrasound parameters in asymptomatic type 2 diabetic (DMT2) patients. MATERIAL AND METHODS: 60 asymptomatic DMT2 patients (pts) without known coronary artery disease (CAD) underwent one day rest Dypiridamole stress Tc-99m sestamibi single photon emission computed tomography myocardial perfusion scintigraphy (MPS)...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28196817/comparison-of-carotid-plaque-score-and-coronary-artery-calcium-score-for-predicting-cardiovascular-disease-events-the-multi-ethnic-study-of-atherosclerosis
#6
Adam D Gepner, Rebekah Young, Joseph A Delaney, Matthew J Budoff, Joseph F Polak, Michael J Blaha, Wendy S Post, Erin D Michos, Joel Kaufman, James H Stein
BACKGROUND: Coronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown. METHODS AND RESULTS: CVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound-detected plaques in the common, bifurcation, and internal carotid artery segments...
February 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28195518/low-salivary-resolvin-d1-to-leukotriene-b4-ratio-predicts-carotid-intima-media-thickness-a-novel-biomarker-of-non-resolving-vascular-inflammation
#7
Silke Thul, Carlos Labat, Mohamed Temmar, Athanase Benetos, Magnus Bäck
Background Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B4 (LTB4) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates the resolution of inflammation. The aim of this study was to determine the association of the RvD1/LTB4 ratio with subclinical atherosclerosis. Methods Saliva samples and ultrasound measurements of the intima media thickness of the carotid artery was obtained for 254 participants...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28191460/assessment-of-influences-of-stenoses-in-right-carotid-artery-on-left-carotid-artery-using-wall-stress-marker
#8
Arindam Bit, Dushali Ghagare, Albert A Rizvanov, Himadri Chattopadhyay
Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region of bifurcation. Such morphological change in vessel largely affects parent as well as corresponding sister and daughter vessels. In this paper, complexity in hemodynamic of blood in pair of carotid arteries (left and right carotid arteries) is evaluated in presence of stenoses at basilar segment of right artery in three-dimensional domain using reconstructed tomographic images of patient...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28190616/plasma-levels-of-vasostatin-1-a-chromogranin-a-fragment-are-associated-with-carotid-artery-maximum-stenosis-a-pilot-study
#9
Tiziana Bachetti, Alberto Ferrari Bardile, Teresa Lucia Aloi, Barbara Colombo, Emma Assi, Giuseppina Savino, Andrea Vercelli, Roberto Colombo, Angelo Corti
BACKGROUND: Chromogranin A (CgA), a circulating protein released by the neuroendocrine system, can regulate vascular physiology and angiogenesis. Full-length CgA (CgA1-439) and its fragment CgA1-76 (called vasostatin-1, VS-1) preserve the physiological integrity of the endothelial barrier function and are antiangiogenic, whereas CgA1-373 is proangiogenic. We investigated whether these polypeptides are altered in patients with various degrees of carotid artery atherosclerosis. METHODS: We studied 81 patients with carotid artery atherosclerosis, asymptomatic for cerebrovascular diseases...
February 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28183353/endothelial-injury-in-rheumatoid-arthritis-a-crosstalk-between-dimethylarginines-and-systemic-inflammation
#10
Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith, George D Kitas
BACKGROUND: Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by high CVD mortality and morbidity. ADMA and SDMA levels are abnormal in RA patients, but their correlation with assessments of endothelial function and structure remains unknown. We aimed to investigate whether SDMA and ADMA are associated with carotid intima media thickness (cIMT) and arterial stiffness as well as non-invasive assessments of in vivo micro- and macrovascular endothelial function in RA patients with high systemic inflammatory load...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28173642/a-novel-urotensin-ii-receptor-antagonist-kr-36996-inhibits-smooth-muscle-proliferation-through-erk-ros-pathway
#11
Tae-Ho Kim, Dong Gil Lee, Young-Ae Kim, Byung Ho Lee, Kyu Yang Yi, Yi-Sook Jung
Urotensin II (UII) is a mitogenic and hypertrophic agent that can induce the proliferation of vascular cells. UII inhibition has been considered as beneficial strategy for atherosclerosis and restenosis. However, currently there is no therapeutics clinically available for atherosclerosis or restenosis. In this study, we evaluated the effects of a newly synthesized UII receptor (UT) antagonist, KR-36996, on the proliferation of SMCs in vitro and neointima formation in vivo in comparison with GSK-1440115, a known potent UT antagonist...
February 6, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28157748/large-artery-atherosclerotic-occlusive-disease
#12
John W Cole
PURPOSE OF REVIEW: Extracranial or intracranial large artery atherosclerosis is often identified as a potential etiologic cause for ischemic stroke and transient ischemic attack. Given the high prevalence of large artery atherosclerosis in the general population, determining whether an identified atherosclerotic lesion is truly the cause of a patient's symptomatology can be difficult. In all cases, optimally treating each patient to minimize future stroke risk is paramount. Extracranial or intracranial large artery atherosclerosis can be broadly compartmentalized into four distinct clinical scenarios based upon the individual patient's history, examination, and anatomic imaging findings: asymptomatic and symptomatic extracranial carotid stenosis, intracranial atherosclerosis, and extracranial vertebral artery atherosclerotic disease...
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28156155/assessment-of-diastolic-dysfunction-arterial-stiffness-and-carotid-intima-media-thickness-in-patients-with-acromegaly
#13
Güven Barış Cansu, Nusret Yılmaz, Atakan Yanıkoğlu, Sebahat Özdem, Aytül Belgi Yıldırım, Gültekin Süleymanlar, Hasan Ali Altunbaş
OBJECTIVE: Early diagnosis and treatment of cardiovascular diseases, the most frequent cause of morbidity and mortality in acromegaly, may be an efficient approach to extending the lifespan of the affected patients. Therefore, it is crucial to determine any cardiovascular diseases in the subclinical period. The study objectives were to determine markers of subclinical atherosclerosis and asses heart structure and functioning. METHODS: This was a cross-sectional single-center study in 53 patients with acromegaly and 22 age- and sex-matched healthy individuals...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28155699/contrast-enhanced-micro-ct-imaging-in-murine-carotid-arteries-a-new-protocol-for-computing-wall-shear-stress
#14
Ruoyu Xing, David De Wilde, Gayle McCann, Yanto Ridwan, Jelle T C Schrauwen, Anton F W van der Steen, Frank J H Gijsen, Kim Van der Heiden
BACKGROUND: Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model. To determine WSS in vivo, detailed 3D geometry of the vessel network is required. However, a protocol to reconstruct 3D murine vasculature using this animal model is lacking. In this project, we evaluated the adequacy of eXIA 160, a small animal contrast agent, for assessing murine vascular network on micro-CT...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155612/the-influence-of-dietary-components-on-early-signs-of-atherosclerosis-in-apparently-healthy-young-adult-males-an-observational-study-of-615-subjects
#15
Girolamo Catapano Minotti, Francesca Cortese, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi, Marco Matteo Ciccone
BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis. DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery. METHODS: 615 males (mean age ± SD: 40...
February 1, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28154582/is-carotid-artery-ultrasound-still-useful-method-for-evaluation-of-atherosclerosis
#16
REVIEW
Gee-Hee Kim, Ho-Joong Youn
Carotid ultrasound is an imaging modality that allows non-invasive assessment of vascular anatomy and function. Carotid intima-media thickness (IMT) has been shown to predict cardiovascular (CV) risk in multiple large studies. However, in 2013, American College of Cardiology/American Heart Association guidelines designated that the carotid IMT as class III evidence level was not recommended for use in clinical practice as a routine measurement of risk assessment for a first atherosclerotic CV event. Following the announcement of this guideline, combined common carotid IMT and plaque, including plaque tissue characterization and plaque burden, using 3D ultrasound was reported to be better than either measurement alone in a variety of studies...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28154165/heritability-of-vascular-structure-and-function-a-parent-child-study
#17
Justin R Ryder, Nathan D Pankratz, Donald R Dengel, James S Pankow, David R Jacobs, Alan R Sinaiko, Vasu Gooty, Julia Steinberger
BACKGROUND: Understanding the heritable contribution of vascular measures, from parent to offspring, may aid in risk stratification and atherosclerosis prevention efforts. We hypothesized that measures of vascular structure and function would be heritable in this cohort of parents and their adolescent offspring. METHODS AND RESULTS: High-resolution ultrasound scans of the brachial and carotid arteries were obtained in parents (n=558) and their offspring (n=369)...
February 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28150376/a-noninvasive-sonographic-study-of-multisite-atherosclerosis-in-an-elderly-chinese-population
#18
Manwei Huang, Daniel S Hippe, Lingyun Huang, Xihai Zhao, Jianwen Luo, Qingyu Zeng, Chun Yuan
OBJECTIVES: A sonographic study was conducted to determine the prevalence of atherosclerosis across multiple arterial beds in an elderly Chinese population and to examine relationships between detected atherosclerosis and traditional risk factors. METHODS: A total of 197 participants underwent sonography of the abdominal aorta and bilateral carotid, femoral, and lower limb arteries. Images were reviewed to determine the presence or absence of plaques in each artery...
February 2, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28150294/muscle-strength-and-carotid-artery-flow-velocity-is-associated-with-increased-risk-of-atherosclerosis-in-adults
#19
Jinkee Park, Hyuntae Park
BACKGROUND: Carotid intima-media thickness (CIMT) has been proposed as a surrogate marker of atherosclerotic disease. In addition, carotid flow velocity (FV) and muscle strength (MS) are reported to be associated with increased CIMT. As there remains insufficient evidence for a complex association of CIMT with FV and MS, the aim of this study was to examine this association in adults. METHODS: A total of 426 adults participated in this study. MS in all subjects was measured by hand grip strength...
February 2, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28148544/advanced-glycation-end-products-oxidation-products-and-the-extent-of-atherosclerosis-during-the-va-diabetes-trial-and-follow-up-study
#20
Aramesh Saremi, Scott Howell, Dawn C Schwenke, Gideon Bahn, Paul J Beisswenger, Peter D Reaven
OBJECTIVE: To determine whether plasma levels of advanced glycation end products and oxidation products play a role in the development of atherosclerosis in patients with type 2 diabetes (T2D) over nearly 10 years of the VA Diabetes Trial and Follow-up Study. RESEARCH DESIGN AND METHODS: Baseline plasma levels of methylglyoxal hydroimidazolone, Nε-carboxymethyl lysine, Nε-carboxyethyl lysine (CEL), 3-deoxyglucosone hydroimidazolone and glyoxal hydroimidazolone (G-H1), 2-aminoadipic acid (2-AAA), and methionine sulfoxide were measured in a total of 411 participants, who underwent ultrasound assessment of carotid intima-media thickness (CIMT), and computed tomography scanning of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) after an average of 10 years of follow-up...
February 1, 2017: Diabetes Care
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