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Atherosclerosis in carotid arteries

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https://www.readbyqxmd.com/read/28718186/intrauterine-growth-restriction-iugr-induces-signs-of-subclinical-atherosclerosis-in-6-year-old-infants-despite-absence-of-excessive-growth
#1
Anja Tzschoppe, Rüdiger von Kries, Ellen Struwe, Wolfgang Rascher, Helmuth-Guenther Dörr, Jörg Jüngert, Manfred Rauh, Matthias Beckmann, Ralf Schild, Tamme W Goecke, Jörg Dötsch
Background Postnatal catch-up growth and rapid weight gain after intrauterine growth restriction (IUGR) seem to increase the risk for later disease. This study aimed to compare features of the metabolic syndrome early in life between IUGR and appropriate for gestational age (AGA) infants. Patients Data for 9 infants with IUGR defined by a birth weight<10(th) percentile and ultrasound-proven placental insufficiency and 11 AGA children were available. Method Postnatal growth, auxological, cardiovascular, and metabolic parameters up to a chronological age of 6 years were assessed: Fasting serum concentrations of LDL-cholesterol, insulin, leptin, IGF-I, DHEAS, skinfold thicknesses, blood pressure, and mean carotid intima-media thickness (cIMT)...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28716818/intimal-hyperplasia-induced-by-vascular-intervention-causes-lipoprotein-retention-and-accelerated-atherosclerosis
#2
Siavash Kijani, Ana Maria Vázquez, Malin Levin, Jan Borén, Per Fogelstrand
Accelerated atherosclerosis diminishes the long term patency of vascular interventions, such as percutaneous coronary intervention and implantation of saphenous vein grafts. However, the cause of this accelerated atherosclerosis is unclear. In this study, we tested the hypothesis that intimal hyperplasia formed following vascular intervention promotes retention of atherogenic lipoproteins. Intimal hyperplasia was surgically induced in the mouse common carotid artery. The surgery was combined with different mouse models of hypercholesterolemia to obtain different cholesterol levels and to control the onsets of hypercholesterolemia...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28715090/learning-based-automated-segmentation-of-the-carotid-artery-vessel-wall-in-dual-sequence-mri-using-subdivision-surface-fitting
#3
Shan Gao, Ronald Van't Klooster, Pieter H Kitslaar, Bram F Coolen, Alexandra M van den Berg, Loek P Smits, Rahil Shahzad, Denis P Shamonin, Patrick J H de Koning, Aart J Nederveen, Rob J van der Geest
PURPOSE: The quantification of vessel wall morphology and plaque burden requires vessel segmentation, which is generally performed by manual delineations. The purpose of our work is to develop and evaluate a new 3D model-based approach for carotid artery wall segmentation from dual-sequence MRI. METHODS: The proposed method segments the lumen and outer wall surfaces including the bifurcation region by fitting a subdivision surface constructed hierarchical-tree model to the image data...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28714271/influence-of-residual-renal-function-in-carotid-modeling-as-a-marker-of-early-atherosclerosis-in-dialysis-patients
#4
Merita Rroji, Nereida Spahia, Saimir Seferi, Myftar Barbullushi, Goce Spasovski
Atherosclerosis is frequently present in patients with chronic kidney disease (CKD) treated with dialysis. We evaluated the association between residual renal function (RRF), phosphate level, inflammation and other risk factors in carotid modeling as a marker of early atherosclerosis in peritoneal dialysis (PD) compared with hemodialysis (HD) patients. We studied 39 stable PD and 53 HD patients on renal replacement therapy (RRT) for 3 to 36 months duration. B-mode ultrasonography was used to determine carotid artery intima media thickness (CIMT)...
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28711962/the-relation-between-hemoglobin-variability-and-carotid-intima-media-thickness-in-chronic-hemodialysis-patients
#5
Safa Ersen Ganidagli, Orcun Altunoren, Ertuğrul Erken, Ismet Onder Isık, Berivan Ganidagli, Necmi Eren, Yasemin Coskun Yavuz, Ozkan Gungor
PURPOSE: Hemoglobin variability is a common problem among hemodialysis patients. We have previously demonstrated an association between Hb variability and left ventricular mass index. In this study, we investigated a possible relation between Hb variability and carotid intima-media thickness (CIMT). METHODS: Twelve-month hemoglobin (Hb) values of 135 patients on maintenance hemodialysis were examined retrospectively. The range of 11-12 gr/dl was accepted as normal according to the KDOQI guidelines...
July 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28709148/impact-of-chronic-methamphetamine-treatment-on-the-atherosclerosis-formation-in-apoe-mice-fed-a-high-cholesterol-diet
#6
Pengfei Zhu, Lun Li, Bo Gao, Mingjing Zhang, Yuting Wang, Ye Gu, Liqun Hu
BACKGROUND: We previously reported that methamphetamine could promote atherosclerosis (AS) in ApoE-/- mice fed normal chow. We herein observed the impact of methamphetamine on AS in ApoE-/- mice fed a high cholesterol diet and explored the potential mechanisms.Results and Materials and Methods: Male ApoE-/- mice fed a high cholesterol diet were treated with saline (NS, n = 5) or methamphetamine [8 mg/kg/day (M8, n = 6) through intraperitoneal injection] for 24 weeks. Afterwards, the percentage area of atheromatous plaque in aortic root (44...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28706202/near-infrared-autofluorescence-induced-by-intraplaque-hemorrhage-and-heme-degradation-as-marker-for-high-risk-atherosclerotic-plaques
#7
Nay Min Htun, Yung Chih Chen, Bock Lim, Tara Schiller, Ghassan J Maghzal, Alex L Huang, Kirstin D Elgass, Jennifer Rivera, Hans G Schneider, Bayden R Wood, Roland Stocker, Karlheinz Peter
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28702876/cardiovascular-histopathology-of-a-11-year-old-with-mucopolysaccharidosis-vii-demonstrates-fibrosis-macrophage-infiltration-and-arterial-luminal-stenosis
#8
Valerie Lew, Louis Pena, Robert Edwards, Raymond Y Wang
Mucopolysaccharidosis type VII (MPS VII) is caused by β-glucuronidase deficiency, resulting in lysosomal accumulation of glycosaminoglycans (GAGs) and multisystemic disease. We present cardiovascular gross and histopathology findings from a 11-year-old MPS VII male, who expired after developing ventricular fibrillation following anesthesia induction. Gross anatomic observations were made at autopsy; postmortem formalin-fixed paraffin-embedded samples of the carotid artery, aorta, myocardium, and valves were sectioned and stained with hematoxylin-eosin, Verhoeff-Van Gieson, CD68, and trichrome stains...
July 13, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28702212/obesity-arterial-function-and-arterial-structure-a-systematic-review-and-meta-analysis
#9
J Y A Ne, T Y Cai, D S Celermajer, I D Caterson, T Gill, C M Y Lee, M R Skilton
OBJECTIVE: Obesity is an established risk factor for cardiovascular disease. The mechanisms by which obesity affects cardiovascular risk have not been fully elucidated. This paper reports a comprehensive systematic review and meta-analysis on obesity and two key aspects of vascular health using gold-standard non-invasive measures - arterial endothelial function (brachial flow-mediated dilatation) and subclinical atherosclerosis (carotid intima-media thickness). METHODS: Electronic searches for 'Obesity and flow-mediated dilatation' and 'Obesity and intima-media thickness' were performed using Ovid Medline and Embase databases...
June 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28695435/evaluation-of-development-of-subclinical-atherosclerosis-in-children-with-uveitis
#10
Seçil Conkar, Suzan Güven Yılmaz, İlker Özgür Koska, Afig Berdeli, Sevgi Mir
Uveitis is a chronic inflammatory disease. Chronic inflammation has been shown to have a role in pathogenesis of atherosclerosis. Atherosclerosis is the most important risk factor of cardiovascular diseases and is shown to start as early as childhood. In this study, we investigated the presence of subclinical atherosclerosis in children with uveitis. Seventy five patients who were diagnosed as having uveitis in ophthalmology and pediatric rheumatology clinics were included in the study. Patients with hypertension, obesity, dyslipidemia, diabetes, and with history of early cardiovascular disease were excluded...
July 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28693985/cardiovascular-risk-markers-among-obese-women-using-the-levonorgestrel-releasing-intrauterine-system-a-randomised-controlled-trial
#11
Lucimara Facio Nobre Zueff, Anderson Sanches de Melo, Carolina S Vieira, Wellington P Martins, Rui A Ferriani
According to international guidelines, women with obesity without other comorbidities can safely use any hormonal contraceptive (HC). However, limited information is available about contraceptive safety for women with obesity since obesity is an exclusion criterion of most contraceptive clinical trials. As such little is known about the possible risks of HC exposure for women with obesity without comorbidities. One way to assess possible long-term risks in this population, even prior to the development of any clinical disease, is to measure alterations in subclinical atherosclerosis markers...
July 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28690216/-plasma-level-of-apelin-and-carotid-atherosclerosis-in-maintenance-hemodialysis-patients
#12
Rong Tang, Ruiling Wang, Xiang Ao, Xiaomiao Cheng
To determine the plasma level of apelin in patients of maintenance hemodialysis (MHD) and to explore the relationship between apelin level and carotid atherosclerosis (AS) in MHD patients.
 Methods: A total of 92 MHD patients and 36 sex- and age-matched healthy subjects were enrolled in this study. The plasma level of apelin was evaluated by radiation immunoassay; serum endothelial injury markers including thrombomodulin, von Willebrand factor (vWF), and CD146, and inflammatory factors including high sensitive C-reactive protein (hsCRP), IL-6 and TNF-α were determined by ELISA...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28690023/the-tyg-index-as-a-marker-of-subclinical-atherosclerosis-and-arterial-stiffness-in-lean-and-overweight-postmenopausal-women
#13
Irene Lambrinoudaki, Maria Vasiliki Kazani, Eleni Armeni, Georgios Georgiopoulos, Konstantinos Tampakis, Demetrios Rizos, Areti Augoulea, Georgios Kaparos, Andreas Alexandrou, Kimon Stamatelopoulos
BACKGROUND: The present study aims to examine the association of the metabolic syndrome (MS) as well as of the triglyceride-glucose index (TyG-Index), a novel marker of insulin resistance, with subclinical atherosclerosis in a cohort of postmenopausal women, stratified according to their body mass index. METHODS: A total of 473 informed-consenting, non-diabetic postmenopausal women, without overt cardiovascular disease, were included in this study. We aimed to compare the association between structural and functional indices of subclinical atherosclerosis (i...
June 16, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28687781/p2x7-receptor-antagonism-modulates-il-1%C3%AE-and-mmp9-in-human-atherosclerotic-vessels
#14
Maria Lombardi, Maria Elena Mantione, Domenico Baccellieri, David Ferrara, Renata Castellano, Roberto Chiesa, Ottavio Alfieri, Chiara Foglieni
In atherosclerosis, matrix metallopeptidases (MMPs) contribute to plaque rupture through weakening of the fibrous cap. Pleiotropic P2X purinoceptor 7 (P2X7), expressed in the carotid plaque (PL), is involved in interleukin 1 beta (IL-1β) release that may influence MMP9 generation, thus their possible modulation through acting on P2X7 was investigated. P2X7-related machinery was characterized and the effects of P2X7 antagonists (A740003, KN62) and MMPs inhibitors (Batimastat, Ro28-2653) were studied in ex-vivo tissue cultures of human PL's vs...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28685504/statins-for-children-with-familial-hypercholesterolemia
#15
REVIEW
Alpo Vuorio, Jaana Kuoppala, Petri T Kovanen, Steve E Humphries, Serena Tonstad, Albert Wiegman, Euridiki Drogari, Uma Ramaswami
BACKGROUND: Familial hypercholesterolemia is one of the most common inherited metabolic diseases and is an autosomal dominant disorder meaning heterozygotes, or carriers, are affected. Those who are homozygous have severe disease. The average worldwide prevalence of heterozygous familial hypercholesterolemia is at least 1 in 500, although recent genetic epidemiological data from Denmark and next generation sequencing data suggest the frequency may be closer to 1 in 250. Diagnosis of familial hypercholesterolemia in children is based on elevated total cholesterol and low-density lipoprotein cholesterol levels or DNA-based analysis, or both...
July 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28682552/-effects-of-oral-interventions-on-carotid-artery-in-rats-with-chronic-periodontitis-for-the-detection-of-porphyromonas-gingivalis-and-the-expression-of-c-reactive-protein
#16
Ren Xiuyun, Wang Chong, Liu Xin, Li Hao, Ma Qianhui, Lin Mu, Shi Xuexue, Gao Jinhua
OBJECTIVE: This study aimed to establish a SD rat model of chronic periodontitis (CP) merged with hyperlipidemia (HL), perform periodontal treatment, detect the expression of partial C-reactive protein (CRP) and Porphyromonas gingivalis (P. gingivalis) in the rat carotid artery, and explore the relationship between periodontitis and atherosclerosis. METHODS: SD rats were randomly divided into three groups: control group (A), HL group (B), and CP+HL group (C). Group C rats were divided into natural process group (C1), scaling and root planning group (C2), and tooth extraction group (C3)...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28679112/an-association-between-residual-vein-thrombosis-and-subclinical-atherosclerosis-cross-sectional-study
#17
Paolo Prandoni, Maurizio Ciammaichella, Nicola Mumoli, Nello Zanatta, Adriana Visonà, Giampiero Avruscio, Giuseppe Camporese, Eugenio Bucherini, Carlo Bova, Davide Imberti, Raffaella Benedetti, Valeria Rossetto, Franco Noventa, Marta Milan
BACKGROUND: The association between venous and arterial thrombotic disorders is still unclear. We assessed the association between residual vein thrombosis (RVT) and subclinical atherosclerosis in a cohort of patients with unprovoked (or associated with weak risk factors) proximal deep-vein thrombosis (DVT). METHODS: In a multicenter cross-sectional study, consecutive patients over 40years free from atherosclerotic disorders received the ultrasound assessment of the leg vein system and that of carotid arteries approximately three months after an episode of proximal DVT...
June 29, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28677755/proteomic-analysis-and-comparison-of-intra%C3%A2-and-extracranial-cerebral-atherosclerosis-responses-to-hyperlipidemia-in-rabbits
#18
Zhi-Lan Tu, Bo Yu, Dong-Ya Huang, Rajeev Ojha, Shu-Kui Zhou, He-Di An, Rong Liu, Cui Du, Nan Shen, Jian-Hui Fu, Shuang-Xing Hou
The present study aimed to investigate protein expression levels of intra‑ and extracranial atherosclerosis in rabbits following administration of a high‑fat diet. Rabbits were randomly divided into control (group A; n=9) and high‑fat diet (group B; n=9) groups. At week 12, tissues were sectioned from the common carotid artery (CCA) and middle cerebral artery (MCA). Pathological analysis was performed. Differential protein expression levels were examined by 2‑D gel electrophoresis (2‑DE) and mass spectrometry (MS) analysis and validated by western blotting...
June 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28676456/palmitoylethanolamide-and-polydatin-combination-reduces-inflammation-and-oxidative-stress-in-vascular-injury
#19
Enrico Gugliandolo, Roberta Fusco, Flavia Biundo, Ramona D'Amico, Filippo Benedetto, Rosanna Di Paola, Salvatore Cuzzocrea
Acute and chronic inflammation responses are important risk factors for vascular remodeling processes such as in atherosclerosis, arteriosclerosis and restenosis. Inflammation and oxidative stress in the intimal region after vascular damage are a key event in the development of neointimal hyperplasia. In this study, we used this model of vascular damage, which involves the complete ligature of the left carotid artery for 14days, to observe the role of N-palmitoylethanolamine in combination with Polydatin at the dose of 30mg/kg, on regulation of inflammatory process, and oxidative stress...
July 1, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28675704/the-metabolic-syndrome-is-associated-with-carotid-atherosclerosis-and-arterial-stiffness-in-asymptomatic-nondiabetic-postmenopausal-women
#20
Irene Lambrinoudaki, Aikaterini Kazani, Eleni Armeni, Demetrios Rizos, Areti Augoulea, Georgios Kaparos, Andreas Alexandrou, Georgios Georgiopoulos, Ioannis Kanakakis, Kimon Stamatelopoulos
The menopause transition is associated with adverse changes in cardiometabolic risk factors. We aimed to examine the association of the metabolic syndrome (MS) and its features with indices of vascular structure and function in a population of asymptomatic postmenopausal women. A total of 473 informed-consenting, nondiabetic postmenopausal women were included in the study. The MS was defined according to the Joint Definition. We evaluated the association between the presence of MS and indices of vascular structure (carotid artery intima-media thickness (IMT); atherosclerotic plaques) and function (flow-mediated dilatation (FMD); pulse wave velocity (PWV))...
July 4, 2017: Gynecological Endocrinology
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