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https://www.readbyqxmd.com/read/29916500/pa-us-dual-modality-imaging-to-guide-vegfr-2-targeted-photothermal-therapy-using-znpc-pfh-loaded-polymeric-nanoparticles
#1
Yu-Li Chen, Feng-Qiu Liu, Yuan Guo, Juan Cheng, Lu Yang, Min Lu, Pan Li, Jie Xu, Tao Yu, Zhi-Gang Wang, Yang Cao, Hai-Tao Ran
Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a novel polymeric nanosystem that encapsulates phthalocyanine zinc (ZnPc) and perfluorohexane (PFH) was developed to target the new blood vessels of breast tumors. After being conjugated to the anti-VEGFR-2 antibody, the polymeric nanoparticles (NPs) targeted vascular endothelial cells efficiently...
June 19, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29892086/carotid-vulnerable-plaques-are-associated-with-circulating-leukocytes-in-acute-ischemic-stroke-patients-an-clinical-study-based-on-contrast-enhanced-ultrasound
#2
Zhaojun Li, Yun Bai, Wanbin Li, Feng Gao, Yi Kuang, Lianfang Du, Xianghong Luo
Inflammatory activity plays a central role in the development of carotid rupture-vulnerable atherosclerotic plaques, which is one of the major contributors to acute ischemic stroke. Our objective was to characterize carotid intraplaque neovascularizations (INP) using contrast-enhanced ultrasound (CEUS) and evaluate plaque burden through exploring the relationship between INP and cell count of peripheral leukocytes. Sixty-two patients with large artery atherosclerosis (LAA) were enrolled in this study. CEUS was performed to characterize the carotid artery plaques...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29805083/neovascularization-in-vertebral-artery-atheroma-a-dynamic-contrast-enhanced-magnetic-resonance-imaging-based-comparative-study-in-patients-with-symptomatic-and-asymptomatic-carotid-artery-disease
#3
Ammara Usman, Jianmin Yuan, Andrew J Patterson, Martin J Graves, Kevin Varty, Umar Sadat, Jonathan H Gillard
BACKGROUND: Atherosclerosis is a systemic inflammatory disease intertwined with neovascularization. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables the assessment of plaque neovascularization. This study aimed to explore the systemic nature of atherosclerosis by assessing difference in severity of neovascularization as quantified by DCE-MRI of vertebral arteries (VAs) between patients with symptomatic and asymptomatic carotid artery disease. METHODS: Ten consecutive patients with asymptomatic VA stenosis and concomitant symptomatic carotid artery disease (group 1) and 10 consecutive patients with asymptomatic VA stenosis and concomitant asymptomatic carotid artery disease (group 2) underwent 3-dimensional DCE-MRI of their cervical segment of VAs...
May 24, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29803682/carotid-artery-plaque-echomorphology-and-its-association-with-histopathologic-characteristics
#4
Konstantinos Spanos, Ioannis Tzorbatzoglou, Paraskevi Lazari, Dimitrios Maras, Athanasios D Giannoukas
OBJECTIVE: The aim of the study was to determine the association of ultrasonic texture features (severity of stenosis, grey scale median, plaque area, juxtaluminal black area [JBA], and discrete white areas) previously shown to be independent predictors for stroke with established histologic features of plaque instability. METHODS: A cross-sectional study was performed involving 70 patients scheduled for carotid endarterectomy. Before surgery, carotid plaque texture features were obtained with ultrasound after normalization using commercially available software (LifeQ Medical, Nicosia, Cyprus)...
May 23, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29754774/evaluation-of-intraplaque-neovascularization-using-superb-microvascular-imaging-and-contrast-enhanced-ultrasonography
#5
Kazumasa Oura, Tadayoshi Kato, Hideki Ohba, Yasuo Terayama
BACKGROUND: Several studies have shown a linkage between intraplaque neovascularization (IPN) and plaque instability. Although contrast-enhanced ultrasonography (CEUS) may help visualize IPN in the carotid artery, its benefits are limited in Japan, where there is no health insurance coverage for contrast agents in medical imaging. Superb microvascular imaging (SMI), however, enables the depiction of low-velocity blood flow. The current study compares the diagnostic accuracy of SMI and CEUS in the evaluation of IPN...
May 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29725384/improved-plaque-neovascularization-following-2-year-atorvastatin-therapy-based-on-contrast-enhanced-ultrasonography-a-pilot-study
#6
Bin Xu, Jin Xing, Wenqing Wu, Wen-Jing Zhang, Qian-Qian Zhu, Dan Zhang, Nan-Nan Sun, Chan Wu, Geng-Jie Kang, Lin Zhai, Wei-Dong Li, Yan Meng, Tie-Ying Du
The present study assessed changes in carotid plaque neovascularization following long-term atorvastatin therapy (20 mg/day) using contrast-enhanced ultrasonography (CEUS). In this prospective case series, seven males (mean age, 68±9 years) and three females (mean age, 67±10 years) with a total of 13 carotid plaques underwent standard ultrasonography and CEUS at baseline, as well as after 1 and 2 years of atorvastatin treatment. The same plaques were then examined using real-time CEUS. The results of the enhanced intensity of plaque neovascularization at baseline were compared with results obtained during follow-up to examine the effects of long-term atorvastatin therapy...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29704490/mathematical-modeling-of-atherosclerotic-plaque-destabilization-role-of-neovascularization-and-intraplaque-hemorrhage
#7
Muyi Guo, Yan Cai, Xinke Yao, Zhiyong Li
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the quantitative evaluation of the role of neoangiogenesis and IPH in the vulnerable atherosclerotic plaque formation. An angiogenic microvasculature is generated by two-dimensional nine-point discretization of endothelial cell proliferation and migration from the vasa vasorum...
August 7, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29699614/neoatherosclerosis-5-years-after-bioresorbable-vascular-scaffold-implantation
#8
Noriaki Moriyama, Koki Shishido, Yutaka Tanaka, Shohei Yokota, Takahiro Hayashi, Hirokazu Miyashita, Tatsuya Koike, Hiroaki Yokoyama, Takuma Takada, Takashi Nishimoto, Tomoki Ochiai, Kazuki Tobita, Futoshi Yamanaka, Shingo Mizuno, Masato Murakami, Saeko Takahashi, Shigeru Saito
BACKGROUND: Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited. OBJECTIVES: This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT). METHODS: Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29697668/-morphometric-characteristics-of-neovascularization-of-carotid-atherosclerotic-plaques
#9
A N Evdokimenko, P L Anufriev, K N Kulichenkova, T S Gulevskaya, M M Tanashyan
OBJECTIVE: to identify the relationship between the magnitude of neovascularization of an atherosclerotic plaque and its other processes, such as atheromatosis, macrophage responses, hemorrhages, and calcification. MATERIAL AND METHODS: 48 carotid atherosclerotic plaques all their way underwent morphopathological examination, by assessing the magnitude of neovascularization (total vessel density per plague cm2 ; density of vessels of different diameters; localization in section), atheromatosis (a volume fraction), foam cells (a score of 0 to 5), hemorrhages (a score of 0 to 4), and calcification (a score of 0 to 4)...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29671719/immune-cells-and-vasa-vasorum-in-the-tunica-media-of-atherosclerotic-coronary-arteries
#10
Ruda Zorc-Pleskovič, Aleš Pleskovič, Olga Vraspir-Porenta, Metka Zorc, Aleksandra Milutinović
In coronary artery disease (CAD), the disruption of the tunica media immune privilege manifests as increased leukocyte infiltration and the formation of vasa vasorum. We aimed to characterize the immune privilege status of the tunica media in human coronary arteries (CAs) with atherosclerotic plaques, by comparing the abundance and composition of immune-cell infiltrates within the individual arterial-wall layers, and by evaluating vasa vasorum neovascularization of the tunica media. The tissue samples were obtained from 36 symptomatic patients with diffuse CAD (aged 60-72 years) who underwent coronary endarterectomy...
April 19, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29669585/endoplasmic-reticulum-stress-in-perivascular-adipose-tissue-promotes-destabilization-of-atherosclerotic-plaque-by-regulating-gm-csf-paracrine
#11
Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. METHODS: We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from donor mice to carotid arteries of recipient apolipoprotein E deficient (apoE-/- ) mice after removing carotid artery collar placed for 6 weeks...
April 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29435774/pet-molecular-targets-and-near-infrared-fluorescence-imaging-of-atherosclerosis
#12
REVIEW
Csilla Celeng, Bart de Keizer, Béla Merkely, Pim de Jong, Tim Leiner, Richard A P Takx
PURPOSE OF REVIEW: With this review, we aim to summarize the role of positron emission tomography (PET) and near-infrared fluorescence imaging (NIRF) in the detection of atherosclerosis. RECENT FINDINGS: 18 F-FDG is an established measure of increased macrophage activity. However, due to its low specificity, new radiotracers have emerged for more specific detection of vascular inflammation and other high-risk plaque features such as microcalcification and neovascularization...
February 12, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29413439/combined-pet-dce-mri-in-a-rabbit-model-of-atherosclerosis-integrated-quantification-of-plaque-inflammation-permeability-and-burden-during-treatment-with-a-leukotriene-a4-hydrolase-inhibitor
#13
Claudia Calcagno, Olivier Lairez, Julie Hawkins, Steven W Kerr, Melanie S Dugas, Thomas Simpson, Jelle Epskamp, Philip M Robson, Mootaz Eldib, Ilda Bander, Purushothaman K-Raman, Sarayu Ramachandran, Alison Pruzan, Audrey Kaufman, Venkatesh Mani, Alexander Ehlgen, Heiko G Niessen, John Broadwater, Zahi A Fayad
OBJECTIVES: The authors sought to develop combined positron emission tomography (PET) dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to quantify plaque inflammation, permeability, and burden to evaluate the efficacy of a leukotriene A4 hydrolase (LTA4H) inhibitor in a rabbit model of atherosclerosis. BACKGROUND: Multimodality PET/MRI allows combining the quantification of atherosclerotic plaque inflammation, neovascularization, permeability, and burden by combined 18 F-fluorodeoxyglucose (18 F-FDG) PET, DCE-MRI, and morphological MRI...
February 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29409899/a-12-year-study-of-slotted-palladium-103-plaque-radiation-therapy-for-choroidal-melanoma-near-touching-or-surrounding-the-optic-nerve
#14
Abhilasha Maheshwari, Paul T Finger
PURPOSE: To present our 12-year experience with low-energy-photon, slotted eye plaque radiation therapy. DESIGN: Retrospective interventional case series. METHODS: Setting: The New York Eye Cancer Center. STUDY POPULATION: Fifty-two consecutive patients with uveal melanomas near, touching, or surrounding the optic disc. INTERVENTION: Slotted eye plaque radiation therapy. MAIN OUTCOME MEASURES: Change in visual acuity, local tumor control, radiation side effects, eye salvage, and systemic metastases...
April 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29407886/noncanonical-nf-%C3%AE%C2%BAb-signaling-in-microvessels-of-atherosclerotic-lesions-is-associated-with-inflammation-atheromatous-plaque-morphology-and-myocardial-infarction
#15
Chrissta X Maracle, Rabia Agca, Boy Helder, John A L Meeuwsen, Hans W M Niessen, Erik A L Biessen, Menno P J de Winther, Saskia C A de Jager, Mike T Nurmohamed, Sander W Tas
BACKGROUND AND AIMS: Neovascularization is associated with atherosclerotic plaque instability and increased chance of myocardial infarction (MI). Patients with chronic inflammatory diseases (CID) have increased risk of atherosclerosis, and evidence demonstrates that NF-κB inducing kinase (NIK)-mediated noncanonical NF-κB signaling in endothelial cells (EC) is linked to inflammation and angiogenesis. Here, we hypothesized NIK may also be activated in EC of atherosclerotic lesion microvessels...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29366159/everolimus-attenuates-atherosclerotic-plaque-progression-intraplaque-neovascularization-myocardial-infarction-and-sudden-death-in-a-mouse-model-of-advanced-atherosclerosis
#16
Ammar Kurdi, Guido R Y De Meyer, Wim Martinet
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29348025/pet-mr-imaging-of-malondialdehyde-acetaldehyde-epitopes-with-a-human-antibody-detects-clinically-relevant-atherothrombosis
#17
Max L Senders, Xuchu Que, Young Seok Cho, Calvin Yeang, Hannah Groenen, Francois Fay, Claudia Calcagno, Anu E Meerwaldt, Simone Green, Phuong Miu, Mark E Lobatto, Thomas Reiner, Zahi A Fayad, Joseph L Witztum, Willem J M Mulder, Carlos Pérez-Medina, Sotirios Tsimikas
BACKGROUND: Oxidation-specific epitopes (OSEs) are proinflammatory, and elevated levels in plasma predict cardiovascular events. OBJECTIVES: The purpose of this study was to develop novel positron emission tomography (PET) probes to noninvasively image OSE-rich lesions. METHODS: An antigen-binding fragment (Fab) antibody library was constructed from human fetal cord blood. After multiple rounds of screening against malondialdehyde-acetaldehyde (MAA) epitopes, the Fab LA25 containing minimal nontemplated insertions in the CDR3 region was identified and characterized...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29336364/mechanism-of-chronic-stress-induced-reduced-atherosclerotic-medial-area-and-increased-plaque-instability-in-rabbit-models-of-chronic-stress
#18
Ze-Mou Yu, Xiao-Tao Deng, Ruo-Mei Qi, Lu-Yan Xiao, Chong-Qing Yang, Tao Gong
BACKGROUND: Chronic stress contributes to increased risks of atherosclerotic diseases including heart disease, stroke, and transient ischemic attack. However, its underline mechanisms are poorly understood. This study aimed to elucidate the mechanism via which chronic stress exerts its effect on atherosclerosis (AS). METHODS: Fifty male New Zealand white rabbits were used. Aortic balloon-injury model was applied. Both social stress and physical stress methods were adopted to establish chronic stress models...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29310647/have-dipeptidyl-peptidase-4-inhibitors-ameliorated-the-vascular-complications-of-type-2-diabetes-in-large-scale-trials-the-potential-confounding-effect-of-stem-cell-chemokines
#19
REVIEW
Milton Packer
Drugs that inhibit dipeptidyl peptidase-4 (DPP-4) are conventionally regarded as incretin-based agents that signal through the glucagon-like peptide-1 (GLP-1) receptor. However, inhibition of DPP-4 also potentiates the stem cell chemokine, stromal cell-derived factor-1 (SDF-1), which can promote inflammation, proliferative responses and neovascularization. In large-scale cardiovascular outcome trials, enhanced GLP-1 signaling has reduced the risk of atherosclerotic ischemic events, potentially because GLP-1 retards the growth and increases the stability of atherosclerotic plaques...
January 8, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29184341/atherosclerotic-carotid-plaques-multimodality-imaging-with-contrast-enhanced-ultrasound-computed-tomography-and-magnetic-resonance-imaging
#20
Divyata R Hingwala, Kesavadas Chandrasekhakan, Bejoy Thomas, P N Sylaja, M Unnikrishnan, T R Kapilamoorthy
Introduction: The imaging of carotid plaques has undergone a paradigm shift increasing importance being given to plaque characterization. Patients with "vulnerable" plaques are more prone to develop future neurovascular events. Purpose: The purpose of this study is to analyze the role of multimodality imaging techniques in the assessment of carotid atherosclerotic plaques. Materials and Methods: Twenty-six patients were prospectively enrolled in the study...
October 2017: Annals of Indian Academy of Neurology
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