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Neovascularization in plaque

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https://www.readbyqxmd.com/read/28223221/the-atheroma-plaque-secretome-stimulates-the-mobilization-of-endothelial-progenitor-cells-ex-vivo
#1
Francisco M Vega, Violette Gautier, Cecilia M Fernandez-Ponce, M J Extremera, A F M Altelaar, Jaime Millan, Juan C Tellez, Jose A Hernandez-Campos, Rosario Conejero, Jorge Bolivar, Ricardo Pardal, Francisco J Garcia-Cózar, Enrique Aguado, Albert J R Heck, Mª Carmen Duran-Ruiz
Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy individuals after direct contact with the factors released by carotid arteries complicated with atherosclerotic plaques (AP), in order to understand the mechanisms underlying the neovascularization and remodeling properties assigned to these cells...
February 20, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28212521/angiogenesis-in-the-atherosclerotic-plaque
#2
REVIEW
Caroline Camaré, Mélanie Pucelle, Anne Nègre-Salvayre, Robert Salvayre
Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries characterized by a local accumulation of cholesterol and non-resolving inflammation. Atherothrombotic complications are the leading cause of disability and mortality in western countries. Neovascularization in atherosclerotic lesions plays a major role in plaque growth and instability. The angiogenic process is mediated by classical angiogenic factors and by additional factors specific to atherosclerotic angiogenesis...
February 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28135035/fibrinolysis-inhibitors-in-plaque-stability-a-morphological-association-pai-1-and-tafi-in-advanced-carotid-plaque
#3
A-C Jönsson Rylander, A Lindgren, J Deinum, G M L Bergström, G Böttcher, I Kalies, K Wåhlander
BACKGROUND: Fibrinolysis plays an important role in destabilization of atherosclerotic plaques and is tightly regulated by specific inhibitors. OBJECTIVE: The fibrinolysis inhibitors PAI-1 and TAFI were quantified and described in the morphological context of advanced carotid plaques (AHA VI-VIII) to elucidate their role in plaque stability. METHODS: Immunohistochemistry in serial sections along the longitudinal axis of endarterectomies from patients with symptomatic carotid stenosis (n=19) were studied using an antibody specific for free PAI-1 (I205), an antibody with high affinity for TAFI/TAFIa (CP17) and established antibodies for SMC (α-actin), endothelial cells (Von Willebrandt Factor, VWF), macrophages (CD68) and platelets (CD42)...
January 30, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28129470/the-water-channel-aqp1-is-expressed-in-human-atherosclerotic-vascular-lesions-and-aqp1-deficiency-augments-angiotensin-ii-induced-atherosclerosis-in-mice
#4
Pamela Wintmo, Søren H Johansen, Pernille B L Hansen, Jes S Lindholt, Sigitas Urbonavicius, Lars M Rasmussen, Peter Bie, Boye L Jensen, Jane Stubbe
AIM: The water channel aquaporin 1 (AQP1) promotes endothelial cell migration. It was hypothesized that AQP1 promotes neovascularization and growth of atherosclerotic plaques. METHODS: AQP1 immunoreactivity and protein abundance was examined in human and murine atherosclerotic lesions and aortic aneurysms. Apolipoprotein E (ApoE) knockout (-/-) and AQP1-/-ApoE-/- were developed and fed western diet (WD) for 8 and 16 weeks to accelerate the atherosclerosis process...
January 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28004000/utility-of-ultrasonography-in-assessing-the-effectiveness-of-extracorporeal-shock-wave-therapy-in-insertional-achilles-tendinopathy
#5
Yi Cheng, Jian Zhang, Yehua Cai
Introduction. The aim of this study was to investigate the utility of ultrasonography (US) for predicting and assessing the effectiveness of extracorporeal shock wave therapy (ESWT) in insertional Achilles tendinopathy (IAT). Methods. A total of 42 patients with an established diagnosis of chronic IAT were examined by US before ESWT and at 4 weeks and 12 weeks after ESWT. The thickness and cross-sectional area (CSA) of the Achilles tendon, size of calcific plaques, tendon structure score, and neovascularization score were measured at each time point...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27986358/novel-ultrasound-methods-to-investigate-carotid-artery-plaque-vulnerability
#6
REVIEW
Amer M Johri, Julia E Herr, Terry Y Li, Olivia Yau, Vijay Nambi
Features of vulnerable plaque include a high lipid content, an irregular shape, a thin fibrous cap, and neovascularization, but such lesions often fall into the category of nonstenotic, despite being at high risk for rupture, and therefore may be overlooked. In this review, the authors describe state-of-the-art investigative ultrasound methods to assess the activity, quality, and morphology of atherosclerotic plaque to determine vulnerability. Specifically, the authors focus on carotid artery plaque, describing the assessment of plaque activity through the detection of neovascularization using contrast-enhanced ultrasound, the characterization of plaque quality by advanced grayscale and integrated backscatter analysis methods, and the assessment of plaque morphology using three-dimensional ultrasound...
December 13, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27884129/in-vivo-optical-coherence-tomography-visualization-of-intraplaque-neovascularization-at-the-site-of-coronary-vasospasm-a-case-report
#7
Kenichi Tsujita, Koichi Kaikita, Satoshi Araki, Toshihiro Yamada, Suguru Nagamatsu, Kenshi Yamanaga, Kenji Sakamoto, Sunao Kojima, Seiji Hokimoto, Hisao Ogawa
BACKGROUND: Coronary plaques in patients with coronary vasospastic angina have been characterized by diffuse intima-media thickening with homogeneous fibrous tissue, without confluent necrotic tissue. However, coronary vasospasm can trigger coronary thrombosis, and may play an important role in the pathogenesis of acute coronary syndromes, though the precise morphological mechanisms underlying this process remain unclear. CASE PRESENTATION: A 43-year-old man with a history of multivessel coronary vasospastic angina had been treated with long-acting diltiazem and fluvastatin since 2004...
November 25, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27828905/macular-telangiectasia-type-2-in-an-otherwise-healthy-teenage-boy-with-consanguineous-parents
#8
Christina L Ryu, Mikel Mikhail, Ayesha Khan, John C Chen, Amer Omar
PURPOSE: To report a case of macular telangiectasia Type 2 in a teenage boy with consanguineous parents. METHOD: Clinical case report and literature review. RESULTS: A healthy 14-year-old boy presented with mildly reduced vision in both eyes. Visual acuity was 20/30 in the right eye and 20/25 in the left eye. Fundus examination revealed intraretinal crystals in both eyes and an intraretinal pigment plaque temporal to the fovea in the left eye...
November 8, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27793409/in-vivo-assessment-of-vasa-vasorum-neovascularization-using-intravascular-ultrasound-a-comparison-between-acute-coronary-syndrome-and-stable-angina-pectoris
#9
Teruyoshi Kume, Hiroyuki Okura, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Yasuhiko Kamata, Hiroshi Okamoto, Tomoko Tamada, Koichiro Imai, Yoji Neishi, Shiro Uemura
BACKGROUND: Previous studies have suggested that vasa vasorum (VV) neovascularization plays an important role in the progression and vulnerability of coronary atherosclerotic plaque. METHODS: A total of 130 patients with coronary artery disease including 75 acute coronary syndrome (ACS) cases and 55 stable angina pectoris (SAP) cases were studied. By using intravascular ultrasound (IVUS), VV was defined as a small (<1mm) tubular or vesicular, low-echoic structure observed exterior to the media...
October 25, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27752526/data-on-consistency-among-different-methods-to-assess-atherosclerotic-plaque-echogenicity-on-standard-ultrasound-and-intraplaque-neovascularization-on-contrast-enhanced-ultrasound-imaging-in-human-carotid-artery
#10
Mattia Cattaneo, Daniel Staub, Alessandra P Porretta, Jeanne Marie Gallino, Paolo Santini, Costanzo Limoni, Rolf Wyttenbach, Augusto Gallino
Here we provide the correlation among different carotid ultrasound (US) variables to assess echogenicity n standard carotid US and to assess intraplaque neovascularization on contrast enhanced US. We recruited 45 consecutive subjects with an asymptomatic≥50% carotid artery stenosis. Carotid plaque echogenicity at standard US was visually graded according to Gray-Weale classification (GW) and measured by the greyscale median (GSM), a semi-automated computerized measurement performed by Adobe Photoshop(®)...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27751505/circulating-cd14-and-cd14-high-cd16-classical-monocytes-are-reduced-in-patients-with-signs-of-plaque-neovascularization-in-the-carotid-artery
#11
Enrico Ammirati, Francesco Moroni, Marco Magnoni, Simona Di Terlizzi, Chiara Villa, Federico Sizzano, Alessio Palini, Katia Garlaschelli, Fernanda Tripiciano, Isabella Scotti, Alberico Luigi Catapano, Angelo A Manfredi, Giuseppe Danilo Norata, Paolo G Camici
BACKGROUND AND AIMS: Monocytes are known to play a key role in the initiation and progression of atherosclerosis and contribute to plaque destabilization through the generation of signals that promote inflammation and neoangiogenesis. In humans, studies investigating the features of circulating monocytes in advanced atherosclerotic lesions are lacking. METHODS: Patients (mean age 69 years, 56% males) with intermediate asymptomatic carotid stenosis (40-70% in diameter) were evaluated for maximal stenosis in common carotid artery, carotid bulb and internal carotid artery, overall disease burden as estimated with total plaque area (TPA), greyscale and neovascularization in 244 advanced carotid plaques...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27677245/evaluation-of-the-thrombus-of-abdominal-aortic-aneurysms-using-contrast-enhanced-ultrasound-preliminary-results
#12
Adam Łukasiewicz, Adam Garkowski, Katarzyna Rutka, Jacek Janica, Urszula Łebkowska
It is hypothesized that the degree of vascularization of the thrombus may have a significant impact on the rupture of aortic aneurysms. The presence of neovascularization of the vessel wall and mural thrombus has been confirmed only in histopathological studies. However, no non-invasive imaging technique of qualitative assessment of thrombus and neovascularization has been implemented so far. Contrast-enhanced ultrasound (CEUS) has been proposed as a feasible and minimally invasive technique for in vivo visualization of neovascularization in the evaluation of tumors and atherosclerotic plaques...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27609368/evaluation-of-68ga-glutamate-carboxypeptidase-ii-ligand-positron-emission-tomography-for-clinical-molecular-imaging-of-atherosclerotic-plaque-neovascularization
#13
Thorsten Derlin, Johannes Thiele, Desiree Weiberg, James T Thackeray, Klaus Püschel, Hans-Jürgen Wester, Lukas Aguirre Dávila, Axel Larena-Avellaneda, Günter Daum, Frank M Bengel, Udo Schumacher
OBJECTIVE: Intraplaque neovascularization contributes to the progression and rupture of atherosclerotic lesions. Glutamate carboxypeptidase II (GCPII) is strongly expressed by endothelial cells of tumor neovasculature and plays a major role in hypoxia-induced neovascularization in rodent models of benign diseases. We hypothesized that GCPII expression may play a role in intraplaque neovascularization and may represent a target for imaging of atherosclerotic lesions. The aim of this study was to determine frequency, pattern, and clinical correlates of vessel wall uptake of a (68)Ga-GCPII ligand for positron emission tomographic imaging...
September 8, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27597156/contrast-enhanced-ultrasound-imaging-of-intraplaque-neovascularization-and-its-correlation-to-plaque-echogenicity-in-human-carotid-arteries-atherosclerosis
#14
Mattia Cattaneo, Daniel Staub, Alessandra P Porretta, Jeanne Marie Gallino, Paolo Santini, Costanzo Limoni, Rolf Wyttenbach, Augusto Gallino
BACKGROUND: Currently the most widely accepted predictor of stroke risk in patients with carotid atherosclerosis is the degree of stenoses. Plaque echogenicity on ultrasound imaging (US) and intraplaque neovascularization (IPNV) are becoming recognized as factors of plaque vulnerability. Aim of the study was to investigate the correlation between the echogenicity of the carotid atherosclerosis by standard US and the degree of IPNV by contrast enhanced US (CEUS). METHODS: We recruited 45 consecutive subjects with an asymptomatic ≥50% carotid artery stenoses...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27580821/assessment-of-the-vulnerable-carotid-atherosclerotic-plaque-using-contrast-enhanced-ultrasonography
#15
Konstantinos Filis, Levon Toufektzian, George Galyfos, Fragiska Sigala, Panagiota Kourkoveli, Sotirios Georgopoulos, Manolis Vavuranakis, Dimitrios Vrachatis, George Zografos
Carotid atherosclerosis represents a primary cause for cerebrovascular ischemic events and its contemporary management includes surgical revascularization for moderate to severe symptomatic stenoses. However, the role of invasive therapy seems to be questioned lately for asymptomatic cases. Numerous reports have suggested that the presence of neovessels within the atherosclerotic plaque remains a significant vulnerability factor and over the last decade imaging modalities have been used to identify intraplaque neovascularization in an attempt to risk-stratify patients and offer management guidance...
January 1, 2016: Vascular
https://www.readbyqxmd.com/read/27563459/cellular-and-molecular-pathology-of-age-related-macular-degeneration-potential-role-for-proteoglycans
#16
REVIEW
Othman Al Gwairi, Lyna Thach, Wenhua Zheng, Narin Osman, Peter J Little
Age-related macular degeneration (AMD) is a retinal disease evident after the age of 50 that damages the macula in the centre of retina. It leads to a loss of central vision with retained peripheral vision but eventual blindness occurs in many cases. The initiation site of AMD development is Bruch's membrane (BM) where multiple changes occur including the deposition of plasma derived lipids, accumulation of extracellular debris, changes in cell morphology, and viability and the formation of drusen. AMD manifests as early and late stage; the latter involves cell proliferation and neovascularization in wet AMD...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27562393/management-and-outcome-of-uveal-melanoma-in-a-single-tertiary-cancer-center-in-jordan
#17
Ahmed Zewar, Ibrahim Nawaiseh, Imad Jaradat, Jakub Khzouz, Khaleel Alrawashdeh, Ghadeer Abdeen, Mustafa Mehyar, Samer Khurma, Yacoub A Yousef
OBJECTIVE: The aim of this study was evaluate the features and outcome of management of uveal melanoma in King Hussein Cancer Center as an example of a referral tertiary cancer center in the Middle East. MATERIAL AND METHOD: This was aetrospective, observational case series of 46 eyes of 46 patients with uveal melanoma. Data collection required access to medical records, radiology and pathology reports, and laboratory results. The main outcome measures included age at diagnosis, tumor location and dimensions, TNM stage, treatment modality, visual outcome, metastasis, and mortality...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27544892/targeted-near-infrared-fluorescence-imaging-of%C3%A2-atherosclerosis-clinical-and-intracoronary-evaluation-of-indocyanine-green
#18
Johan W Verjans, Eric A Osborn, Giovanni J Ughi, Marcella A Calfon Press, Ehsan Hamidi, Antonios P Antoniadis, Michail I Papafaklis, Mark F Conrad, Peter Libby, Peter H Stone, Richard P Cambria, Guillermo J Tearney, Farouc A Jaffer
OBJECTIVES: This study sought to determine whether indocyanine green (ICG)-enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. BACKGROUND: New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administration-approved NIRF imaging agent that experimentally targets plaque macrophages and lipid in areas of enhanced endothelial permeability...
September 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27454303/-functional-and-morphological-microstructural-changes-in-sd-oct-in-long-term-treatment-for-neovascular-amd-with-ranibizumab-monotherapy-versus-combination-therapy-with-pdt
#19
K Wand, K Tetz, I R Fischinger, C P Lohmann, M M Maier, N Feucht
Background: Intravitreal anti-VEGF therapy is the gold standard in the treatment of neovascular age-related macular degeneration (nAMD). In recent literature, the benefit of additional photodynamic therapy (PDT) has been debated. The aim of our study was to compare the functional and structural effects of long-term combination therapy with PDT plus ranibizumab with monotherapy with ranibizumab. Material and Methods: In a retrospective study, patients suffering from nAMD were followed up for at least 42 months...
July 25, 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27452862/the-therapeutic-effect-of-bevacizumab-on-plaque-neovascularization-in-a-rabbit-model-of-atherosclerosis-during-contrast-enhanced-ultrasonography
#20
Yang Li, Ying Zhu, Youbin Deng, Yani Liu, Yuhang Mao, Junli Wang, Jie Sun
The purpose of the study was to assess the therapeutic effect of the angiogenesis inhibitor bevacizumab on plaques of various stages in rabbit models using contrast-enhanced ultrasonography (CEUS). Abdominal aortic atherosclerosis was induced in 55 rabbits. Thirty-six randomly selected rabbits were divided into 2 groups according to the timing of the bevacizumab injection: an early-stage plaque group (Group ESP) and a later-stage plaque group (Group LSP). The remainder were considered the control group. Standard ultrasonography and CEUS imaging of the abdominal aorta were performed...
2016: Scientific Reports
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