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https://www.readbyqxmd.com/read/29666651/relative-risk-chart-score-for-the-assessment-of-the-cardiovascular-risk-in-young-patients-with-ankylosing-spondylitis
#1
Javier Rueda-Gotor, Fernanda Genre, Alfonso Corrales, Ricardo Blanco, Patricia Fuentevilla, Virginia Portilla, Rosa Expósito, Cristina Mata Arnaiz, Trinitario Pina, Carlos González-Juanatey, Luis Rodriguez-Rodriguez, Miguel A González-Gay
Objective: To determine if the use of the relative risk (RR) chart score may help to identify young ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease. Methods: 73 AS patients younger than 50 years were assessed. CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) and the RR chart score. C-reactive protein (CRP) value at disease diagnosis and carotid ultrasound data were also analyzed...
2018: International Journal of Rheumatology
https://www.readbyqxmd.com/read/29665863/effect-of-combined-treatment-with-bisphosphonate-and-vitamin-d-on-atherosclerosis-in-patients-with-systemic-lupus-erythematosus-a-propensity-score-based-analysis
#2
Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M Ito, Norihiro Sato, Tatsuya Atsumi
BACKGROUND: Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim of this study is to explore correlation between the development of atherosclerosis and anti-osteoporotic treatment. METHODS: Consecutive patients with SLE (n = 117) who underwent carotid ultrasonography were retrospectively analyzed using propensity scoring...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29665456/the-contribution-of-obesity-to-carotid-atherosclerotic-plaque-burden-in-a-general-population-sample-in-norway-the-troms%C3%A3-study
#3
Yume Imahori, Ellisiv B Mathiesen, David A Leon, Laila A Hopstock, Alun D Hughes, Stein Harald Johnsen, Lone Jørgensen, Nina Emaus, Katy E Morgan
BACKGROUND AND AIMS: Few studies have investigated the association of different measures of adiposity with carotid plaque. We aimed to investigate and compare the associations of four measures of adiposity: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) with the presence of carotid plaque and total plaque area (TPA) in the right carotid artery. METHODS: We included 4906 individuals aged 31-88 years who participated in a population-based study with ultrasonography of the right carotid artery...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29657758/temporal-and-spatial-changes-in-wall-shear-stress-during-atherosclerotic-plaque-progression-in-mice
#4
R Xing, A M Moerman, Y Ridwan, M J Daemen, A F W van der Steen, F J H Gijsen, K van der Heiden
Wall shear stress (WSS) is involved in atherosclerotic plaque initiation, yet its role in plaque progression remains unclear. We aimed to study (i) the temporal and spatial changes in WSS over a growing plaque and (ii) the correlation between WSS and plaque composition, using animal-specific data in an atherosclerotic mouse model. Tapered casts were placed around the right common carotid arteries (RCCA) of ApoE-/- mice. At 5, 7 and 9 weeks after cast placement, RCCA geometry was reconstructed using contrast-enhanced micro-CT...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29656628/cerebral-thromboembolic-events-during-anterior-cervical-spine-surgery-retrospective-case-series-study-with-diffusion-weighted-magnetic-resonance-imaging-follow-up-in-the-immediate-postoperative-period
#5
Seok-Won Chung, Min-Soo Kang, Sang-Ho Lee, Shin-Young Lee, Yong-Hwan Shin, Chan-Hong Park
OBJECTIVE: We evaluated the efficacy of diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting perioperative cerebral thromboembolic events after anterior cervical discectomy and fusion (ACDF). METHODS: This retrospective case series included 51 consecutive patients that underwent ACDF. To assess baseline presence of plaque or stenosis, all patients were assessed for risk factors of cerebrovascular events and underwent carotid ultrasound preoperatively and cerebral DW-MRI was performed in all patients postoperatively, with areas of high signal intensity interpreted as a cerebral thromboembolic event...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656494/oxidized-ldl-phagocytosis-during-foam-cell-formation-in-atherosclerotic-plaques-relies-on-a-pld2-cd36-functional-interdependence
#6
Ramya Ganesan, Karen M Henkels, Lucile E Wrenshall, Yasunori Kanaho, Gilbert Di Paolo, Michael A Frohman, Julian Gomez-Cambronero
The uptake of cholesterol carried by low-density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the cellular consequences of excess cholesterol leading to their transformation into "foam cells," an early step in vascular plaque formation. We have uncovered and characterized a novel mechanism involving phospholipase D (PLD) in foam cell formation. Utilizing bone marrow-derived macrophages from genetically PLD deficient mice, we demonstrate that PLD2 (but not PLD1)-null macrophages cannot fully phagocytose aggregated oxidized LDL (Agg-Ox-LDL), which was phenocopied with a PLD2-selective inhibitor...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29652660/cognitive-function-of-patients-with-rheumatoid-arthritis-is-associated-with-disease-activity-but-not-carotid-atherosclerotic-changes
#7
Ji Hyun Lee, Geun-Tae Kim, Yun-Kyung Kim, Seung-Geun Lee
OBJECTIVES: Although the relationship between atherosclerosis and cognitive impairment has been studied and replicated, whether cognitive deficits in RA can be attributed to atherosclerotic changes is not well understood. This study investigated cognitive function in patients with RA and evaluated whether cognitive function was affected by carotid arterial atherosclerosis. METHODS: We examined 70 RA patients and 40 healthy controls. RA activity was assessed by disease activity score with 28 joint-erythrocyte sedimentation rate (DAS28-ESR)...
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29649236/predictive-value-for-cardiovascular-events-of-common-carotid-intima-media-thickness-and-its-rate-of-change-in-individuals-at-high-cardiovascular-risk-results-from-the-prog-imt-collaboration
#8
Matthias W Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R Srinivasan, Lars Lind, Shuhei Okazaki, Coen D A Stehouwer, Peter Willeit, Joseph F Polak, Helmuth Steinmetz, Dirk Sander, Holger Poppert, Moise Desvarieux, M Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R Sirtori, Bernhard Iglseder, Oscar Beloqui, Gunnar Engström, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta-Chen Su, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Völzke, Giel Nijpels, Johann Willeit, Ralph L Sacco, Oscar H Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo-Liong Chien, Jackie F Price, Göran Bergström, Jussi Kauhanen, Elena Tremoli, Marcus Dörr, Gerald Berenson, Kazuo Kitagawa, Jacqueline M Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B Mathiesen, Samuela Castelnuovo, Manuel F Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Jing Liu, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L Bots, David N Yanez, Simon G Thompson
AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events...
2018: PloS One
https://www.readbyqxmd.com/read/29648468/in-healthy-normotensive-subjects-age-and-blood-pressure-better-predict-subclinical-vascular-and-cardiac-organ-damage-than-atherosclerosis-biomarkers
#9
Alessandro Maloberti, Francesca Farina, Marco Carbonaro, Enrico Piccinelli, Ilaria Bassi, Francesco Pansera, Guido Grassi, Giuseppe Mancia, Paola Palestini, Cristina Giannattasio
PURPOSE: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI-1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases. MATERIALS AND METHODS: 480 blood donors participated at the present analysis...
April 12, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29628278/left-atrial-dilatation-a-target-organ-damage-in-young-to-middle-age-hypertensive-patients-the-campania-salute-network
#10
Costantino Mancusi, Grazia Canciello, Raffaele Izzo, Silvia Damiano, Maria Gabriella Grimaldi, Nicola de Luca, Giovanni de Simone, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Left atrial (LA) volume is a predictor of outcome in hypertension. It is unclear whether or not this effect depends on coexisting target organ damage (TOD). PURPOSE: To investigate whether LA volume predicts outcome independently of TOD [left ventricular (LV) hypertrophy (LVH) and/or carotid plaque] in a registry of hypertensive treated patients. METHODS: From the Campania Salute Network registry, we selected 5844 young adult hypertensive patients <65 years old (mean age 50 ± 9 years, 41% women, 8% diabetic) without prevalent CV or valvular heart disease more than mild, with normal LV ejection fraction, stage III or less CKD and available follow-up...
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29627372/psoas-and-paraspinous-muscle-index-as-a-predictor-of-mortality-in-african-american-men-with-type-2-diabetes-mellitus
#11
Mariana Murea, Leon Lenchik, Thomas C Register, Gregory B Russell, Jianzhao Xu, S Carrie Smith, Donald W Bowden, Jasmin Divers, Barry I Freedman
AIM: Recent studies revealed a correlation between skeletal muscle mass index and density with longevity; these studies largely evaluated appendicular skeletal muscles in older Caucasians. This retrospective cohort study assessed the association between axial skeletal muscles size and density with survival in African Americans with type 2 diabetes mellitus. METHODS: Psoas and paraspinous muscle mass index (cross sectional area/height2 ) and radiographic density (in Hounsfield Units) were measured using computed tomography in African American-Diabetes Heart Study participants, 314 women and 256 men, with median (25th, 75th quartile) age 55...
March 19, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29625727/effectiveness-of-screening-postmenopausal-women-for-cardiovascular-diseases-a-population-based-prospective-parallel-cohort-study
#12
Marie Dahl, Rikke Søgaard, Lars Frost, Annette Høgh, Jes Lindholt
OBJECTIVES: To investigate the effectiveness of systematic screening for multifaceted cardiovascular disease (CVD) in postmenopausal women on all cause mortality and, secondarily, on CVD morbidity. Effectiveness was also evaluated across age strata. METHODS: This was a population based, prospective, parallel cohort study. In total, 107,491 women born in 1936-1951 living in the Central Denmark region were identified in the Danish Civil Registration System. From this population, all women born in 1936, 1941, 1946, and 1951 (n = 1984) living in the Viborg municipality were invited to attend screening...
April 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29622590/carotid-atherosclerosis-detected-by-ultrasonography-a-national-cross-sectional-study
#13
Xiaojun Wang, Wenzhen Li, Fujian Song, Longde Wang, Qian Fu, Shiyi Cao, Yong Gan, Wei Zhang, Wei Yue, Feng Yan, Wenhuan Shi, Xiaoli Wang, Hong Zhang, Hao Zhang, Zhihong Wang, Zuxun Lu
BACKGROUND: Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrasonography and related risk factors based on a national survey in China. METHODS AND RESULTS: A total of 107 095 residents aged ≥40 years from the China National Stroke Prevention Project underwent carotid ultrasound examination...
April 5, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29622017/correction-to-type-2-diabetes-associated-carotid-plaque-burden-is-increased-in-patients-with-retinopathy-compared-to-those-without-retinopathy
#14
Núria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández, Didac Mauricio
The author found errors in Table 1 after publication of the original article [1].
April 5, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29619417/nonalcoholic-fatty-liver-disease-contributes-to-subclinical-atherosclerosis-a-systematic-review-and-meta-analysis
#15
Yao-Yao Zhou, Xiao-Dong Zhou, Sheng-Jie Wu, Dan-Hong Fan, Sven Van Poucke, Yong-Ping Chen, Shen-Wen Fu, Ming-Hua Zheng
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of atherosclerotic cardiovascular disease. In our meta-analysis, we aimed to assess the correlation of NAFLD and four surrogate markers of subclinical atherosclerosis. PubMed, Embase, and the Cochrane Library were searched up until April 2017. Original studies investigating the association between NAFLD and subclinical atherosclerosis were included. The outcome data were extracted and pooled for the effect estimate by using a random-effects model...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29618596/alternative-splicing-of-foxp3-controls-regulatory-t-cell-effector-functions-and-is-associated-with-human-atherosclerotic-plaque-stability
#16
Anne-Laure Joly, Christina Seitz, Sang Liu, Nikolai V Kouznetsov, Karl Gertow, Lisa S Westerberg, Gabrielle Paulsson-Berne, Göran K Hansson, John Andersson
<u>Rationale:</u> Regulatory T (Treg) cells suppress immune responses and have been shown to attenuate atherosclerosis. The Treg cell lineage specification factor FOXP3 is essential for Treg cells' ability to uphold immunological tolerance. In humans, FOXP3 exists in several different isoforms, however, their specific role is poorly understood. <u>Objective:</u> To define the regulation and functions of the two major FOXP3 isoforms, FOXP3fl and FOXP3Δ2, as well as to establish whether their expression is associated with ischemic atherosclerotic disease...
April 4, 2018: Circulation Research
https://www.readbyqxmd.com/read/29618474/cruciferous-and-total-vegetable-intakes-are-inversely-associated-with-subclinical-atherosclerosis-in-older-adult-women
#17
Lauren C Blekkenhorst, Catherine P Bondonno, Joshua R Lewis, Richard J Woodman, Amanda Devine, Nicola P Bondonno, Wai H Lim, Kun Zhu, Lawrence J Beilin, Peter L Thompson, Richard L Prince, Jonathan M Hodgson
BACKGROUND: Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years)...
April 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29617044/pcsk9-plays-a-novel-immunological-role-in-the-oxidized-ldl-induced-dendritic-cell-maturation-and-t-cell-activation-from-human-blood-and-atherosclerotic-plaque
#18
Anquan Liu, Johan Frostegård
BACKGROUND: Activated T cells and dendritic cells (DCs) occur in atherosclerotic plaques. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR), and results in increased LDL-levels. We here investigate immune effects of PCSK9 on OxLDL induced DC maturation and T cell activation. METHODS: T cells were isolated from carotid specimens of patients undergoing carotid endarterectomy, or from peripheral blood of healthy individuals. Human peripheral blood monocytes were differentiated into DCs...
April 4, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29609131/hepatocyte-growth-factor-is-associated-with-progression-of-atherosclerosis-the-multi-ethnic-study-of-atherosclerosis-mesa
#19
Elizabeth J Bell, Paul A Decker, Michael Y Tsai, James S Pankow, Naomi Q Hanson, Christina L Wassel, Nicholas B Larson, Kevin P Cohoon, Matthew J Budoff, Joseph F Polak, James H Stein, Suzette J Bielinski
BACKGROUND AND AIMS: Hepatocyte growth factor (HGF) has previously been associated with risk of stroke, coronary heart disease, and atherosclerosis. We hypothesized that higher circulating HGF is associated with greater progression of measures of atherosclerosis: coronary artery calcium (CAC) and carotid plaque. METHODS: Participants aged 45-84 years from the prospective cohort study Multi-Ethnic Study of Atherosclerosis had HGF measured at baseline (between 2000 and 2002) and were followed for progression of atherosclerosis for up to 12 years...
March 23, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29605471/thermal-heterogeneity-of-carotid-arteries-as-a-novel-biomarker-in-patients-with-diabetes-mellitus-assessed-for-coronary-artery-disease
#20
G Tzanis, M Bonou, G Benetos, S Biliou, S Liatis, C Kapelios, K Toutouzas, D Tousoulis, J Barbetseas
BACKGROUND: Vulnerable plaque plays crucial role in prognosis of diabetes mellitus (DM). Microwave radiometry (MWR) allows measurement of the temperature of tissues, thus indirectly reflecting inflammation, a characteristic of atherosclerotic plaque stability. Aim of the study was to evaluate the relation of carotid artery inflammation with glycemic control and presence of coronary artery disease (CAD). METHODS: We included 112 patients (65 ± 9 years, 30 ± 5 kg/m2 , 74 DM and 38 non-DM, with a 2:1 ratio) that were referred for scheduled coronary angiography (CA) for evaluation of their clinical condition...
March 29, 2018: International Journal of Cardiology
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