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https://www.readbyqxmd.com/read/29453675/evaluation-of-carotid-artery-elasticity-in-patients-with-uremia-by-echo-tracking
#1
Hong Liang, Dawei Wang, Guoying Che, Yanxin Su
PURPOSE: The purpose of this study was to compare the carotid artery wall elasticity between patients with uremia and controls using echo tracking (ET). METHODS: Ninety-three patients with uremia and 35 control subjects (Group A) were enrolled in this study. In the ET mode, the carotid artery elasticity parameters including stiffness index (β), pressure-strain elasticity modulus (EP), arterial compliance (AC), and one-point pulse wave velocity (PWVβ) were measured, and carotid intima-media thickness (IMT) was measured with B-mode ultrasonography...
February 16, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29453087/interleukin-6-is-an-independent-predictor-of-progressive-atherosclerosis-in-the-carotid-artery-the-troms%C3%A3-study
#2
Agnethe Eltoft, Kjell Arne Arntzen, Tom Wilsgaard, Ellisiv B Mathiesen, Stein Harald Johnsen
BACKGROUND AND AIMS: Novel biomarkers are linked to cardiovascular disease (CVD). The aim of the present study was to investigate the association between 28 blood biomarkers and the formation and progression of carotid plaque. METHODS: In a nested case control study with 703 participants from the population based Tromsø Study, a large biomarker panel was measured in blood obtained at baseline. Carotid ultrasound was assessed both at baseline and at 6 years of follow-up...
February 7, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29452833/endothelial-vascular-cell-adhesion-molecule-1-is-a-marker-for-high-risk-carotid-plaques-and-target-for-ultrasound-molecular-imaging
#3
Craig C Weinkauf, Kirsten Concha-Moore, Jonathan R Lindner, Edmund R Marinelli, Kyle P Hadinger, Sandipan Bhattacharjee, Scott S Berman, Kay Goshima, Luis R Leon, Terry O Matsunaga, Evan Unger
BACKGROUND: Molecular imaging of carotid plaque vulnerability to atheroembolic events is likely to lead to improvements in selection of patients for carotid endarterectomy (CEA). The aims of this study were to assess the relative value of endothelial inflammatory markers for this application and to develop molecular ultrasound contrast agents for their imaging. METHODS: Human CEA specimens were obtained prospectively from asymptomatic (30) and symptomatic (30) patients...
February 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29449352/association-between-short-sleep-duration-and-carotid-atherosclerosis-modified-by-age-in-a-chinese-community-population
#4
Si Chen, Ying Yang, Guan-Liang Cheng, Jia Jia, Fang-Fang Fan, Jian-Ping Li, Yong Huo, Yan Zhang, Da-Fang Chen
BACKGROUND AND AIM: Short sleep duration is a risk factor of cardiovascular disorder; however, the association between short sleep duration and carotid atherosclerosis has not been completely characterised. The aim of this study is to investigate the association between short sleep duration and carotid atherosclerosis. METHODS: We used the cross-sectional data collected between May 2014 and July 2014, which were based on a cardiovascular disease cohort study including 3798 participants aged 40 years and older who are residents of Beijing, China...
February 15, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29446645/the-relationship-of-perivascular-adipose-tissue-and-atherosclerosis-in-the-aorta-and-carotid-arteries-determined-by-magnetic-resonance-imaging
#5
Mohammad Alkhalil, Evan Edmond, Laurienne Edgar, Janet E Digby, Omar Omar, Matthew D Robson, Robin P Choudhury
BACKGROUND AND AIMS: Imaging studies have relied on the 'overall' volumetric quantification of perivascular adipose tissue. We sought to assess the relationship of circumferential distribution between perivascular adipose tissue and adjacent wall thickness of carotid and aortic arteries using dedicated magnetic resonance imaging sequences. METHODS: Vessel wall and perivascular adipose tissue were acquired using magnetic resonance imaging (1.5 T). Co-registered images were segmented separately, and measurements of both perivascular adipose tissue and vessel wall were obtained along radii of the vessel spaced at angles of 5° each...
February 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29445076/clinical-utility-of-carotid-ultrasonography-in-the-prediction-of-cardiovascular-events-in-patients-with-diabetes-a-combined-analysis-of-data-obtained-in-five-longitudinal-studies
#6
Naoto Katakami, Tomoya Mita, Masahiko Gosho, Mitsuyoshi Takahara, Yoko Irie, Tetsuyuki Yasuda, Taka-Aki Matsuoka, Takeshi Osonoi, Hirotaka Watada, Iichiro Shimomura
AIM: It remains unclear whether measures used in carotid ultrasonography such as the intima-media thickness (IMT) and ultrasonic tissue characterization of the carotid using the gray-scale median (GSM) can add prognostic information beyond the conventional cardiovascular risk markers in patients with diabetes. METHODS: This study employed a combined analysis of data obtained in five longitudinal studies including a total of 3263 patients with diabetes but without apparent cardiovascular disease (CVD) at baseline...
February 14, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29438198/the-association-of-c-reactive-protein-with-subclinical-cardiovascular-disease-in-hiv-infected-and-hiv-uninfected-women
#7
Caitlin A Moran, Anandi N Sheth, C C Mehta, David B Hanna, Deborah R Gustafson, Michael W Plankey, Wendy J Mack, Phyllis C Tien, Audrey L French, Elizabeth T Golub, Arshed Quyyumi, Robert C Kaplan, Ighovwerha Ofotokun
OBJECTIVE: HIV is a cardiovascular disease (CVD) risk factor. However, CVD risk is often underestimated in HIV-infected women. C-reactive protein (CRP) may improve CVD prediction in this population. We examined the association of baseline plasma CRP with subclinical CVD in women with and without HIV. DESIGN: Retrospective cohort study. METHODS: A total of 572 HIV-infected and 211 HIV-uninfected women enrolled in the Women's Interagency HIV Study underwent serial high-resolution B-mode carotid artery ultrasonography between 2004 and 2013 to assess carotid intima-media thickness (CIMT) and focal carotid artery plaques...
February 12, 2018: AIDS
https://www.readbyqxmd.com/read/29436628/gene-expression-profile-analysis-of-the-progression-of-carotid-atherosclerotic-plaques
#8
Wangmi Liu, Yanxin Zhao, Jiayan Wu
The present study aimed to examine the universal gene expression signature and the underlying molecular mechanisms involved in the progression of carotid atherosclerotic plaques. The gene expression dataset, GSE28829, containing 13 early and 16 advanced carotid atherosclerotic plaques was selected for analysis. The differentially expressed genes (DEGs) were identified and analyzed using bioinformatics analyses, including cluster analysis, Gene Ontology (GO) and pathway enrichment analyses. Finally, a protein‑protein interaction (PPI) was constructed and analyzed...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435736/cardiovascular-studies-in-patients-with-chronic-obstructive-pulmonary-disease-due-to-biomass-smoke-or-tobacco
#9
Rafael Golpe, Pilar Sanjuán-López, Irene Martín-Robles, Carlos González-Juanatey, Luis Pérez-de-Llano, José L López-Campos
BACKGROUND AND OBJECTIVE: The cardiovascular effects of biomass smoke exposure in patients with chronic obstructive pulmonary disease are not well characterized, and few studies have assessed the possible differences between patients with disease caused by biomass smoke and tobacco. The aim of this study was to search for differences in cardiovascular variables between both types of the disease. METHODS: Twenty subjects (15 men, 5 women) with chronic obstructive pulmonary disease caused by tobacco were matched one to one for sex, age, and forced expiratory volume in 1 s to 20 patients with biomass-related disease...
February 12, 2018: Lung
https://www.readbyqxmd.com/read/29435269/current-understanding-of-chronic-total-occlusion-of-the-internal-carotid-artery
#10
Baofeng Xu, Chao Li, Yunbao Guo, Kan Xu, Yi Yang, Jinlu Yu
At present, there is limited understanding of chronic total occlusion (CTO) of the internal carotid artery (ICA). Therefore, the present report collected related cases from PubMed and reviewed the literature. Cerebral vessels may form collateral circulation immediately or gradually following CTO of the ICA. The natural history of CTO of the ICA includes a variety of outcomes, all of which are biased toward a non-benign progressive process and are characterized by insufficient cerebral perfusion, embolus detachment and cognitive dysfunction...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29434795/correlations-of-mmp-1-mmp-3-and-mmp-12-with-the-degree-of-atherosclerosis-plaque-stability-and-cardiovascular-and-cerebrovascular-events
#11
Wei Hu, Rui Wei, Liyue Wang, Jingqian Lu, Hongming Liu, Wei Zhang
We analyzed the effects of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-12 on the degree of carotid atherosclerosis (CAS) and plaque stability, and investigated their correlations with cardiovascular and cerebrovascular events (CCEs). Two hundred CAS patients were enrolled. Carotid intima-media thickness (IMT) was measured using ultrasonic examination. Patients were divided into the no plaque group (NP group), stable plaque group (SP group), and vulnerable plaque group (VP group). The Crouse method was used for the evaluation of plaque scores...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434750/comparative-analysis-of-3d-time-resolved-contrast-enhanced-magnetic-resonance-angiography-color-doppler-ultrasound-and-digital-subtraction-angiography-in-symptomatic-carotid-stenosis
#12
Hongkai Cui, Ruifang Yan, Zhansheng Zhai, Jipeng Ren, Zheng Li, Qiang Li, Shouying Wang
The present study aimed to compare the diagnostic value of contrast-enhanced magnetic resonance angiography (CE MRA) with 3D time-resolved imaging of contrast kinetics, color Doppler ultrasound (CDUS) and digital subtraction angiography (DSA) in extracranial carotid stenosis (CS). A total of 54 patients with symptomatic CS were subjected to CDUS, CE MRA and DSA examination. Results of DSA were defined as the standard, and a total of 216 vessels were examined. In each patient four vessels were examined, namely the bilateral common carotid arteries and the bilateral internal carotid arteries...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432661/is-pulmonary-vascular-disease-reversible-with-ppar-%C3%A9-agonists
#13
Peter Afdal, Antoine F AbdelMassih
Severe angio-obliterative pulmonary vascular disease (PAH) remains a disease characterized by great morbidity and shortened survival. Unfortunately, the only currently available treatments for angio-obliterative changes are palliative in the form of pulmonary vasodilators evolving from the phosphodiesterase inhibitor sildenafil to endothelin receptor antagonist: Bosentan; while the only definitive treatment is lung transplantation which remains dependent on the availability of donors and the transplant policies which vary widely from a country to another...
February 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29432486/fractal-analysis-of-plaque-border-a-novel-method-for-the-quantification-of-atherosclerotic-plaque-contour-irregularity-is-associated-with-pro-atherogenic-plasma-lipid-profile-in-subjects-with-non-obstructive-carotid-stenoses
#14
Francesco Moroni, Marco Magnoni, Vittoria Vergani, Enrico Ammirati, Paolo G Camici
BACKGROUND AND AIMS: Plaque border irregularity is a known imaging characteristic of vulnerable plaques, but its evaluation heavily relies on subjective evaluation and operator expertise. Aim of the present work is to propose a novel fractal-analysis based method for the quantification of atherosclerotic plaque border irregularity and assess its relation with cardiovascular risk factors. METHODS AND RESULTS: Forty-two asymptomatic subjects with carotid stenosis underwent ultrasound evaluation and assessment of cardiovascular risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29425278/carotid-intima-media-thickness-and-silent-brain-infarctions-in-a-biracial-cohort-the-atherosclerosis-risk-in-communities-aric-study
#15
Melissa C Caughey, Ye Qiao, B Gwen Windham, Rebecca F Gottesman, Thomas H Mosley, Bruce A Wasserman
Background: Both hypertensive and atherosclerotic processes contribute to common carotid artery intima-media thickness (CCA-IMT). Elevated CCA-IMT may be indicative of subclinical cerebrovascular disease; however, its role in the absence of concomitant carotid artery plaque is uncertain, and few studies have examined associations in black populations. Materials and Methods: At cohort visit 3 (1993-1995) a subset of stroke-free participants (641 blacks and 702 whites, mean age 63) from the Atherosclerosis Risk in Communities (ARIC) study was imaged by brain MRI and carotid ultrasound...
February 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29420356/dose-effect-of-irbesartan-on-cyclooxygenase-2-and-matrix-metalloproteinase-9-expression-in-rabbit-atherosclerosis
#16
Lihua Li, Juan Li, Jing Yi, Hang Liu, Han Lei
Irbesartan has previously shown antiatherosclerotic effects on human carotid atherosclerotic plaques. Our study aimed to assess the dose-effect of irbesartan on cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in rabbit atherosclerotic aorta. New Zealand rabbits were randomly divided into 6 groups: normal control (NC), high cholesterol (HC), low-dose (10 mg·kg·day), medium-dose (20 mg·kg·d), and high-dose (30 mg·kg·d) irbesartan and celecoxib (20 mg·kg·d). Except for the NCs, rabbits were fed a HC diet for 14 weeks to induce atherosclerosis...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29420090/lxr%C3%AE-is-expressed-at-higher-levels-in-healthy-people-compared-to-atherosclerosis-patients-and-its-over-expression-polarizes-macrophages-towards-an-anti-inflammatory-m%C3%AE-2-phenotype
#17
Mengyuan Liu, Weijian Yang, Shuling Liu, Duncan Hock, Bohao Zhang, Ruth Ya Huo, Xiaoguang Tong, Hua Yan
OBJECTIVES: (1) To investigate the expression patterns of MΦ1 and MΦ2 phenotype markers of peripheral blood monocyte (PBMC)-derived macrophages in atherosclerosis patients and healthy controls, as well as the expression correlation among these genes. (2) To elucidate whether a high level of liver X receptor α (LXRα) expression is associated with anti-inflammatory MΦ2-type polarization. DESIGN: Peripheral blood monocytes (PBMCs) were obtained from 28 patients with carotid artery plaques and 10 normal persons, who did not have carotid artery plaques...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29415228/plasma-tryptophan-kynurenine-metabolites-are-altered-in-hiv-infection-and-associated-with-progression-of-carotid-artery-atherosclerosis
#18
Qibin Qi, Simin Hua, Clary B Clish, Justin M Scott, David B Hanna, Tao Wang, Sabina A Haberlen, Sanjiv J Shah, Marshall J Glesby, Jason M Lazar, Robert D Burk, Howard N Hodis, Alan L Landay, Wendy S Post, Kathryn Anastos, Robert C Kaplan
Background: It is unknown whether disrupted tryptophan catabolism is associated with cardiovascular disease (CVD) in HIV-infected individuals. Methods: Plasma tryptophan and kynurenic acid were measured among 737 women and men (520 HIV+, 217 HIV-) from the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained among these participants in 2004-2013. We examined associations of baseline plasma tryptophan, kynurenic acid, and kynurenic acid-to-tryptophan (KYNA/TRP) ratio, a measure of tryptophan catabolism, with risk of carotid artery plaque...
February 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29409453/factors-associated-with-carotid-intima-media-thickness-and-carotid-plaque-score-in-community-dwelling-and-non-diabetic-individuals
#19
Javad Alizargar, Chyi-Huey Bai
BACKGROUND: The carotid intima media thickness (cIMT) and carotid plaque score (cPS) are respective markers of early and late stage subclinical atherosclerosis. Relationships between some laboratory parameters and subclinical atherosclerosis are not yet clear in community dwelling individuals and non-diabetic subjects, so we try to elucidate these relationships and find a model to predict early and late stage subclinical atherosclerosis. METHODS: We examined relationships of the cIMT and cPS with different laboratory and demographic data of 331 subjects from a community-based prospective cohort study, using univariate and multivariate analyses...
February 6, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29407996/carotid-plaque-segmentation-from-three-dimensional-ultrasound-images-by-direct-three-dimensional-sparse-field-level-set-optimization
#20
Jieyu Cheng, Yimin Chen, Yanyan Yu, Bernard Chiu
Total plaque volume (TPV) measured from 3D carotid ultrasound has been shown to be able to predict cardiovascular events and is sensitive in detecting treatment effects. Manual plaque segmentation was performed in previous studies to quantify TPV, but is tedious, requires long training times and is prone to observer variability. This article introduces the first 3D direct volume-based level-set algorithm to segment plaques from 3D carotid ultrasound images. The plaque surfaces were first initialized based on the lumen and outer wall boundaries generated by a previously described semi-automatic algorithm and then deformed by a direct three-dimensional sparse field level-set algorithm, which enforced the longitudinal continuity of the segmented plaque surfaces...
January 11, 2018: Computers in Biology and Medicine
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