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https://www.readbyqxmd.com/read/28441536/the-effect-of-forage-types-on-the-fatty-acid-profile-lipid-and-protein-oxidation-and-retail-colour-stability-of-muscles-from-white-dorper-lambs
#1
Gerlane F De Brito, Benjamin W B Holman, Shawn R McGrath, Michael A Friend, Remy van de Ven, David L Hopkins
The aim of this study was to evaluate the effect of different forage-types on lamb meat quality parameters. White Dorper lambs that had grazed five forage-types, were slaughtered commercially. At 24h post-mortem, the m. longissimus lumborum (LL) was removed from one side, sliced into three equal sub-samples, vacuum packaged and assigned to ageing periods (5, 12 or 40days); the other side of LL was aged for 5days. The m. adductor femoris was used for fatty acid analysis. Lambs fed chicory+arrowleaf clover had the highest concentration of health claimable omega-3 fatty acids and the lowest omega-6:omega-3 fatty acid ratio...
April 4, 2017: Meat Science
https://www.readbyqxmd.com/read/28441337/a-study-of-the-differential-effects-of-eicosapentaenoic-acid-epa-and-docosahexaenoic-acid-dha-on-gene-expression-profiles-of-stimulated-thp-1-macrophages
#2
Bénédicte Allam-Ndoul, Frédéric Guénard, Olivier Barbier, Marie-Claude Vohl
Background: An appropriate intake of omega-3 (n-3) fatty acids (FAs) such as eicosapentaenoic and docosahexaenoic acid (EPA/DHA) from marine sources is known to have anti-inflammatory effects. However, molecular mechanisms underlying their beneficial effects on health are not fully understood. The aim of the present study was to characterize gene expression profiles of THP-1 macrophages, incubated in either EPA or DHA and stimulated with lipopolysaccharide (LPS), a pro-inflammatory agent. Methods: THP-1 macrophages were incubated into 10, 50 and 75 µM of EPA or DHA for 24 h, and 100 nM of LPS was added to the culture media for 18 h...
April 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28441155/do-triglyceride-lowering-drugs-decrease-risk-of-cardiovascular-disease
#3
Kevin C Maki, Mary R Dicklin
PURPOSE OF REVIEW: This review summarizes the evidence supporting a relationship between lowering triglycerides (TGs) and TG-rich lipoprotein cholesterol (TGRL-C) levels and reduced atherosclerotic cardiovascular disease (ASCVD) event risk. RECENT FINDINGS: Data from observational investigations, including studies of genetic variants, provide evidence consistent with a causal relationship between elevations in TG and TGRL-C and greater risk for ASCVD. Randomized controlled trial evidence of ASCVD risk reduction with therapies that substantially lower TG and TGRL-C is limited by the fact that no large-scale trial results have been published from a study that enrolled subjects selected specifically on the basis of TG or TGRL-C elevation, although three such trials are underway or in the planning stages...
April 22, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28440951/concluding-the-trilogy-the-interaction-of-2-2-dihydroxy-benzophenones-and-their-carbonyl-n-analogues-with-human-glutathione-transferase-m1-1-face-to-face-with-the-p1-1-and-a1-1-isoenzymes-involved-in-mdr
#4
Nikolaos D Georgakis, Dionisis A Karagiannopoulos, Trias N Thireou, Elias E Eliopoulos, Nikolaos E Labrou, Petros G Tsoungas, Michael N Koutsilieris, Yannis D Clonis
The conjugation of intracellular glutathione (GSH) with several electrophilic, predominantly hydrophobic, endogenous and xenobiotic compounds, such as chemotherapeutics and carcinogenics, agrochemicals and other drugs, is catalyzed by the multigene enzyme family of glutathione transferases (GSTs). The mammalian family of GSTs comprises three groups: cytosolic, mitochondrial and microsomal. Human cytosolic GSTs constitute the largest family, which is classified in seven distinct classes named Alpha (Α), Mu (M), Pi (P), Theta (T), Sigma (S), Zeta (Z) and Omega (O)...
April 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28439746/plasma-phosphatidylethanolamine-and-triacylglycerol-fatty-acid-concentrations-are-altered-in-major-depressive-disorder-patients-with-seasonal-pattern
#5
Yurika Otoki, Marie Hennebelle, Anthony J Levitt, Kiyotaka Nakagawa, Walter Swardfager, Ameer Y Taha
Disturbances in peripheral and brain lipid metabolism, including the omega-3 fatty acid docosahexaenoic acid (DHA), have been reported in major depressive disorder (MDD). However, these changes have yet to be confirmed in MDD with seasonal pattern (MDD-s), a subtype of recurrent MDD. The present exploratory study quantified plasma plasmalogen and diacyl-phospholipid species, and fatty acids within total phospholipids, cholesteryl esters, triacylglycerols and free fatty acids in non-medicated MDD-s participants (n = 9) during euthymia in summer or fall, and during depression in winter in order to screen for potential high sensitivity lipid biomarkers...
April 24, 2017: Lipids
https://www.readbyqxmd.com/read/28439740/synthetic-cold-inducible-promoter-enhances-recombinant-protein-accumulation-during-agrobacterium-mediated-transient-expression-in-nicotiana-excelsior-at-chilling-temperatures
#6
I M Gerasymenko, Y V Sheludko
OBJECTIVES: To exploit cold-inducible biochemical processes beneficial for foreign mRNA transcription, translation and storage, as well as protein product stability, during Agrobacterium-mediated transient expression. RESULTS: The efficiency of three different 5'-regulatory sequences to achieve transient expression of the GFP-based reporter gene under chilling conditions (6-8 °C since the 3rd day post inoculation) was compared. We studied the upstream sequences of a cold-inducible Arabidopsis thaliana cor15a gene, the core element of 35S CaMV promoter fused to the TMV omega 5'-UTR, and the synthetic promoter including the 35S core sequence and two binding sites for cold-inducible CBF transcription factors (P_DRE::35S)...
April 24, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28436716/skin-score-correlates-with-global-dna-methylation-and-gsto1-a140d-polymorphism-in-arsenic-affected-population-of-eastern-india
#7
Moumita Majumder, Uma B DasGupta, D N Guha Mazumder, Nilansu Das
Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene and promoter specific hypermethylation has been reported in different arsenic exposed cell lines, whereas whole genome DNA methylation study suggested genomic hypo and hypermethylation after arsenic exposure in in-vitro and in-vivo studies. Along with other characteristic biomarkers, arsenic toxicity leads to typical skin lesions. The present study demonstrates significant correlation between severities of skin manifestations with their whole genome DNA methylation status as well as with a particular polymorphism (Ala 140 Asp) status in arsenic metabolizing enzyme Glutathione S-transferase Omega-1 (GSTO1) in arsenic exposed population of the district of Nadia, West Bengal, India...
April 24, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28436486/muscle-wasting-and-cachexia-in-heart-failure-mechanisms-and-therapies
#8
REVIEW
Stephan von Haehling, Nicole Ebner, Marcelo R Dos Santos, Jochen Springer, Stefan D Anker
Body wasting is a serious complication that affects a large proportion of patients with heart failure. Muscle wasting, also known as sarcopenia, is the loss of muscle mass and strength, whereas cachexia describes loss of weight. After reaching guideline-recommended doses of heart failure therapies, the most promising approach to treating body wasting seems to be combined therapy that includes exercise, nutritional counselling, and drug treatment. Nutritional considerations include avoiding excessive salt and fluid intake, and replenishment of deficiencies in trace elements...
April 24, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28436384/dynamical-electrical-conductivity-of-graphene
#9
Luxmi Rani, Navinder Singh
For graphene (a Dirac material) it has been theoretically predicted and experimentally observed that DC resistivity is proportional to $ T^4$ when the temperature is much less than Bloch-Gr\"{u}neisen temperature ($\Theta_{BG}$) and T-linear in opposite case ($T\gg\Theta_{BG}$). Going beyond this case, we investigate the dynamical electrical conductivity in graphene using the powerful methods the memory function formalism. In the zero frequency regime, we obtain the above mentioned behavior which was previously obtained using the Bloch-Boltzmann kinetic equation...
April 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28434760/omega-3-fatty-acid-supplementation-is-associated-with-oxidative-stress-and-dyslipidemia-but-does-not-contribute-to-better-lipid-and-oxidative-status-on-hemodialysis-patients
#10
Andresa Marques de Mattos, José Abrão Cardeal da Costa, Alceu Afonso Jordão Júnior, Paula Garcia Chiarello
OBJECTIVE: The aim of the study was to explore the effects of n-3 polyunsaturated fatty acids (PUFA) supplementation in physiological doses on oxidative stress (OS) and dyslipidemia in patients on hemodialysis (HD). DESIGN AND METHODS: Randomized, double-blind, controlled, experimental trial. A total of 88 HD patients ≥18 years old and on HD for at least 6 months. A total of 43 patients received 1.28 g/day of n-3 PUFA, and 45 other patients received soybean oil for 12 weeks...
April 20, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28434427/prenatal-fish-oil-supplementation-and-early-childhood-development-in-the-upstate-kids-study
#11
K Vollet, A Ghassabian, R Sundaram, N Chahal, E H Yeung
Fish oil contains omega-3 fatty acids, which play a vital role in fetal growth and development. In utero exposure to omega-3 fatty acids is exclusively dependent on maternal nutrition. Previous studies have suggested that prenatal fish oil supplementation has positive impacts on child neurodevelopment later in life. This study examines the associations between fish oil supplementation both before pregnancy and throughout pregnancy and subsequent child development. Mother-child pairs from the Upstate KIDS Study, a birth cohort consisting of children born between 2008 and 2010, were included...
April 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28433363/the-molecular-impact-of-omega-3-fatty-acids-on-hepatic-pro-inflammatory-cytokine-signaling
#12
George J Ventro, Yingkui Yang, Min Chen, Carroll M Harmon
PURPOSE: Parenteral nutrition associated liver disease (PNALD) develops in a subset of children receiving parenteral nutrition for intestinal failure. Omegaven™ is an omega-3 fatty acid (Ω3FA) lipid emulsion high in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) that can lessen PNALD. Inflammatory cytokines (IL-1, TNF-α, TGF-β) are elevated in PNALD and can decrease paraoxonase 1 protein expression (PON1). We sought to determine the effect of Omegaven™, EPA, and DHA on inflammatory cytokines TNF-α, IL-1, and TGF-β via ERK1/2 and p-Smad2/3 signaling pathways as well as the changes in intracellular PON1 protein expression as a potential mechanism explaining the protective effects of Omegaven™ and Ω3FA...
March 18, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28432661/lipid-biomarkers-for-risk-assessment-in-acute-coronary-syndromes
#13
REVIEW
Jeffrey W Meeusen, Leslie J Donato, Allan S Jaffe
PURPOSE OF REVIEW: The objective of this review was to summarize evidence gathered for the prognostic value of routine and novel blood lipids and lipoproteins measured in patients with acute coronary syndromes (ACS). RECENT FINDINGS: Data supports clear association with risk and actionable value for non-high-density lipoprotein (Non-HDL) cholesterol and plasma ceramides in a setting of ACS. The prognostic value and clinical actionability of apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)] in ACS have not been thoroughly tested, while the data for omega-3 fatty acids and oxidized low-density lipoprotein (Ox-LDL) are either untested or more varied...
June 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28432658/does-supplementation-with-omega-3-pufas-add-to-the-prevention-of-cardiovascular-disease
#14
REVIEW
Evangelos C Rizos, Moses S Elisaf
PURPOSE OF REVIEW: Omega-3 fatty acids are increasingly used for the protection of cardiovascular disease. The main but not the sole mechanism of action is the reduction of triglyceride levels. In this review, we summarize the effect of omega-3 supplements on all-cause and cardiovascular mortality, myocardial infarction, and stroke from the relevant randomized controlled trials. RECENT FINDINGS: Twenty-one randomized controlled trials assessed omega-3 supplementation on mortality and cardiovascular-related outcomes...
June 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28431260/standardization-of-brief-inventory-of-social-support-exchange-network-bissen-in-japan
#15
Miyuki Aiba, Hirokazu Tachikawa, Yoshiharu Fukuoka, Adam Lebowitz, Yuki Shiratori, Nagafumi Doi, Yutaka Matsui
This study describes the Brief Inventory of Social Support Exchange Network (BISSEN) as a standardized brief inventory measuring various aspects of social support. We confirmed the reliability and validity for function and direction of support and standardized the BISSEN. For Sample 1, a stratified random sampling method was used to select 5200 residents in Japan. We conducted mail surveys and responses were retrieved from 2274 participants (collection rate 43.7%). Participants completed a questionnaire packet that included BISSEN, suicidal ideation, depression, support seeking, and Multidimensional Scale of Perceived Social Support (MSPSS)...
April 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28431151/dietary-choline-and-phospholipid-supplementation-enhanced-docosahexaenoic-acid-enrichment-in-egg-yolk-of-laying-hens-fed-a-2-schizochytrium-powder-added-diet
#16
H Wang, H J Zhang, X C Wang, S G Wu, J Wang, L Xu, G H Qi
The aim of this study was to evaluate the effect of dietary phospholipid supplementation on laying hen performance, egg quality, and the fatty acid profile of egg yolks from hens fed a 2% Schizochytrium powder diet. Three-hundred-sixty 28-wk-old Hy-line W-36 laying hens were randomly allocated to one of the 5 dietary treatments, each treatment with 6 replicates of 12 birds each. All diets included 2% Schizochytrium powder (docosahexaenoic acid [DHA], 137.09 mg/g). The control group was not supplemented with any additional phospholipids, whereas the other 4 experimental diets were supplemented with 1,000 mg/kg choline (CHO), 1,000 mg/kg monoethanolamine (MEA), 1,000 mg/kg lysophosphatidylcholine (LPC), or 500 mg/kg LPC + 500 mg/kg MEA (LPC + MEA)...
April 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28430792/the-influence-of-sagittal-profile-alteration-and-final-lordosis-on-the-clinical-outcome-of-cervical-spondylotic-myelopathy-a-delta-omega-analysis
#17
Daniel Koeppen, Claudia Piepenbrock, Stefan Kroppenstedt, Mario Čabraja
PURPOSE: Decompression and maintaining or restoring a cervical lordosis are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Numerous studies support the assumption that cervical lordosis is a key factor for neurological recovery and pain reduction. However, even kyphotic patients can be asymptomatic. The balance of the spine is subject of an increasing number of publications. The main purpose of the study was to evaluate the validity of lordotic alignment on the course of CSM and to set this parameter in context with well-validated tools, namely the modified Japanese Orthopaedic Association scoring system (mJOAS) and the visual analogue scale (VAS), to predict and measure the clinical outcome after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28429633/the-reliability-of-multidimensional-neuropsychological-measures-from-alpha-to-omega
#18
Marley W Watkins
OBJECTIVE: To demonstrate that Coefficient omega, a model-based estimate, is more a more appropriate index of reliability than coefficient alpha for the multidimensional scales that are commonly employed by neuropsychologists. METHOD: As an illustration, a structural model of an overarching general factor and four first-order factors for the WAIS-IV based on the standardization sample of 2200 participants was identified and omega coefficients were subsequently computed for WAIS-IV composite scores...
April 21, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28429367/can-type-1-diabetes-progression-be-halted-possible-role-of-high-dose-vitamin-d-and-omega-3-fatty-acids
#19
F Cadario, S Savastio, A M Rizzo, D Carrera, G Bona And C Ricordi
In Type 1 Diabetes (T1D) in children, close to the onset the requirements of insulin are often reduced. This represents a transient recovery of endogenous insulin secretion named "honeymoon" because transient and followed by a progressive decline in C-peptide secretion. This case report describes the effect of administration of high dose vitamin D and Ω-3 fatty acids on T1D progression in a 8-year-old child. At today after one year and a half from the onset of T1D, the subject shows a near-normal blood glucose with the administration of 1...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429067/neuronal-oscillations-and-synchronicity-associated-with-gamma-hydroxybutyrate-during-resting-state-in-healthy-male-volunteers
#20
Robin von Rotz, Michael Kometer, Dario Dornbierer, Jürg Gertsch, M Salomé Gachet, Franz X Vollenweider, Erich Seifritz, Oliver G Bosch, Boris B Quednow
RATIONALE: Gamma-hydroxybutyrate (GHB) is a putative neurotransmitter, a drug of abuse, an anesthetic agent, and a treatment for neuropsychiatric disorders. In previous electroencephalography (EEG) studies, GHB was shown to induce an electrophysiological pattern of "paradoxical EEG-behavioral dissociation" characterized by increased delta and theta oscillations usually associated with sleep during awake states. However, no detailed source localization of these alterations and no connectivity analyses have been performed yet...
April 20, 2017: Psychopharmacology
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