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B Mazel-Sanchez, I Boal Carvalho, F Silva, R Dijkman, M Schmolke
Highly pathogenic IAV from avian hosts were first reported to directly infect humans 20 years ago. However, these are rare events and our understanding of factors promoting or restricting zoonotic transmission is still limited. One accessory protein of IAV, PB1-F2, was associated with pathogenicity of pandemic and zoonotic IAV. This 90-amino-acid-short peptide does not harbor an enzymatic function. We thus identified host factors interacting with H5N1 PB1-F2, which could explain its importance for virulence...
March 21, 2018: Journal of Virology
Catarina S H Jesus, Pedro Fernandes Cruz, Luis G Arnaut, Rui M M Brito, Carlos Serpa
The understanding of fast folding dynamics of single α-helices comes mostly from studies on rationally designed peptides displaying sequences with high helical propensity. The folding/unfolding dynamics and energetics of α-helix conformations in naturally occurring peptides remains largely unexplored. Here we report the study of a protein fragment analogue of the C-peptide from bovine pancreatic ribonuclease-A, RN80, a 13-amino acid residue peptide that adopts a highly populated helical conformation in aqueous solution...
March 20, 2018: Journal of Physical Chemistry. B
Carlos Pomares-Noguera, Francisco Ayala, Francisco Javier Robles-Palazón, Juan F Alomoto-Burneo, Alejandro López-Valenciano, José L L Elvira, Sergio Hernández-Sánchez, Mark De Ste Croix
Objective: To analyze the training effects of the FIFA 11+ kids on several parameters of physical performance in male youth football players. Materials and methods: Twenty-three youth players were randomized within each team into two groups (control vs. intervention). The intervention group performed the FIFA 11+ kids programme 2 times a week for 4 weeks; the control groups completed their normal warm-up routines. Thirteen physical performance measures {range of motion (hip, knee, and ankle joints), dynamic postural control (measured throughout the Y balance test), 20 m sprint time, slalom dribble with a ball, agility, vertical jumping height [counter movement jump (CMJ) and drop jump (DJ)], horizontal jump distance, accuracy when volleying a ball [measured throughout the Wall Volley test]} were assessed...
2018: Frontiers in Pediatrics
Thais Regina de Mattos Lourenco, Priscila Katsumi Matsuoka, Edmund Chada Baracat, Jorge Milhem Haddad
INTRODUCTION AND HYPOTHESIS: People are increasingly aware of healthy lifestyles. Extenuating practice can injure the pelvic floor. Urinary incontinence (UI) is a prevalent condition in women whether they exercise professionally or not. The most common symptom is stress UI. It is reported in a large variety of sports and may interfere with everyday life or training, leading athletes to change or compromise their performance or risk compromising it. We aimed to assess the prevalence of UI in female athletes and to determine whether the type of sport might also influence UI...
March 19, 2018: International Urogynecology Journal
Olaf Prieske, Tom Krüger, Markus Aehle, Erik Bauer, Urs Granacher
Power training programs have proved to be effective in improving components of physical fitness such as speed. According to the concept of training specificity, it was postulated that exercises must attempt to closely mimic the demands of the respective activity. When transferring this idea to speed development, the purpose of the present study was to examine the effects of resisted sprint (RST) vs. traditional power training (TPT) on physical fitness in healthy young adults. Thirty-five healthy, physically active adults were randomly assigned to a RST ( n = 10, 23 ± 3 years), a TPT ( n = 9, 23 ± 3 years), or a passive control group ( n = 16, 23 ± 2 years)...
2018: Frontiers in Physiology
Myungho Lee, Gerd Bruder, Tobias Hollerer, Greg Welch
In this paper, we investigate factors and issues related to human locomotion behavior and proxemics in the presence of a real or virtual human in augmented reality (AR). First, we discuss a unique issue with current-state optical see-through head-mounted displays, namely the mismatch between a small augmented visual field and a large unaugmented periphery, and its potential impact on locomotion behavior in close proximity of virtual content. We discuss a potential simple solution based on restricting the field of view to the central region, and we present the results of a controlled human-subject study...
April 2018: IEEE Transactions on Visualization and Computer Graphics
Stuart K Kim, John P A Ioannidis, Marwa A Ahmed, Andrew L Avins, John P Kleimeyer, Michael Fredericson, Jason L Dragoo
Plantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. To identify genetic loci associated with plantar fascial disorders, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 21,624 cases of plantar fascial disorders and 80,879 controls...
March 13, 2018: International Journal of Sports Medicine
Curtis L Tomasevicz, Jack W Ransone, Christopher W Bach
The requisite combination of speed, power, and strength necessary for a bobsled push athlete coupled with the difficulty in directly measuring pushing ability makes selecting effective push crews challenging. Current practices by USA Bobsled and Skeleton (USABS) utilize field combine testing to assess and identify specifically selected performance variables in an attempt to best predict push performance abilities. Combine data consisting of 11 physical performance variables were collected from 75 subjects across two winter Olympic qualification years (2009 and 2013)...
March 12, 2018: Journal of Strength and Conditioning Research
Koushun Kamada, Ryousuke Tachibanagi, Hideki Nakagawa
Toads on the ground control landing behavior by a simple strategy in which they extend their elbows at roughly the same time after take-off and continue extending them at the same velocity until they land. However, this simple strategy does not work well in much more complicated arboreal habitat. We analyzed properties of jumping and timing of forelimb extension of the tree frog, Hyla japonica, to demonstrate how the arboreal species land safely. The results showed that distance, duration, and velocity of jump were not affected by explicit optic flow information, whereas the all three parameters decreased significantly in the blindfolded animals...
March 13, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Katherine A J Daniels, J F Burn
It is generally accepted that animals move in a way that minimises energy use during regular gait and there is evidence that the principle might extend more generally to locomotor behaviour and manoeuvres. Jumping during locomotion is a useful manoeuvre that contributes to the versatility of legged locomotion and is within the repertoire of many terrestrial animals. We describe a simple ballistic model that can be used to identify a single unique trajectory of the body's centre of mass that minimises the mechanical work to initiate a jump, regardless of the approach velocity or take-off position...
March 12, 2018: Journal of Experimental Biology
Samantha K Rowbotham, Soren Blau, Jacqueline Hislop-Jambrich
The term 'B.A.S.E jump' refers to jumping from a building, antenna, span (i.e., bridge) or earth (i.e., cliff) structure, and parachuting to the ground. There are numerous hazards associated with B.A.S.E jumps which often result in injury and, occasionally, fatality. This case report details the skeletal trauma resulting from a fatal B.A.S.E jump in Australia. In this case, the jumper impacted the ground from a fall of 439m in a feet-first landing position, as a result of a partially deployed parachute, under extreme vertical deceleration...
February 27, 2018: Forensic Science International
Roger L Hammer, Joshua T Linton, Adam M Hammer
The purpose of this investigation was to determine maximal strength and jump performance outcomes of heavy squat training on a low-amplitude (<1.0 mm peak-to-peak) vibration platform (VP). Nineteen recreationally resistance-trained college-aged men (22.3 ± 1.66 years) completed the 6-week study. Participants were randomly assigned to one of two training groups: SQT (n = 10) performed conventional back squats on the floor; SQTV (n = 9) performed back squats on the VP. Supervised training took place over 12 sessions (2 days/week) which utilized an aggressive strength development protocol (85-95 % 1-RM), which was identically followed by both groups...
March 6, 2018: Journal of Strength and Conditioning Research
Jozo Grgic, Eric T Trexler, Bruno Lazinica, Zeljko Pedisic
Background: Caffeine is commonly used as an ergogenic aid. Literature about the effects of caffeine ingestion on muscle strength and power is equivocal. The aim of this systematic review and meta-analysis was to summarize results from individual studies on the effects of caffeine intake on muscle strength and power. Methods: A search through eight databases was performed to find studies on the effects of caffeine on: (i) maximal muscle strength measured using 1 repetition maximum tests; and (ii) muscle power assessed by tests of vertical jump...
2018: Journal of the International Society of Sports Nutrition
Helene Moser, Monika Leitner, Patric Eichelberger, Annette Kuhn, Jean-Pierre Baeyens, Lorenz Radlinger
PURPOSE: Stress urinary incontinence (SUI) symptoms can be provoked during impact loads such as vertical jumps. To investigate and compare pelvic floor muscle (PFM) activity in women with SUI and continent women (CON) during drop jumps (DJ) and counter movement jumps (CMJ) could clarify the activity of the PFMs during impact loads. METHODS: A tripolar vaginal probe was used to record surface electromyographic (EMG) activity of the PFMs during DJ and CMJ. Time intervals of 30 ms were used to parameterize data from 30 ms before (pre-activity) to 150 ms after (reflex activity) ground contact on a force plate during the landing and take-off phase...
March 10, 2018: Archives of Gynecology and Obstetrics
Svetlana S Efimova, Evgeny G Chulkov, Olga S Ostroumova
The effects of local anesthetics (LAs), namely, lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), bupivacaine (BPV), procaine (PC), and tetracaine (TTC), on the steady-state transmembrane conductance induced by the cis-side addition of the antifungal polyene macrolide antibiotic, nystatin (NYS), in planar lipid bilayers were studied. The addition of TTC to model membranes comprising DOPC and cholesterol (33 mol%) led to a nearly twenty-fold increase in the steady-state NYS-induced membrane conductance...
March 8, 2018: Colloids and Surfaces. B, Biointerfaces
Kim Hébert-Losier, Lina Schelin, Eva Tengman, Andrew Strong, Charlotte K Häger
BACKGROUND: Anterior cruciate ligament (ACL) ruptures may lead to knee dysfunctions later in life. Single-leg tasks are often evaluated, but bilateral movements may also be compromised. Our aim was to use curve analyses to examine double-leg drop-jump kinematics in ACL-reconstructed, ACL-deficient, and healthy-knee cohorts. METHODS: Subjects with unilateral ACL ruptures treated more than two decades ago (17-28years) conservatively with physiotherapy (ACLPT , n=26) or in combination with reconstructive surgery (ACLR , n=28) and healthy-knee controls (n=25) performed 40-cm drop-jumps...
March 7, 2018: Knee
Giovanna Camparis Lessi, Rodrigo Scattone Silva, Fábio Viadanna Serrão
OBJECTIVES: Studies comparing the effects of fatigue between men and women after anterior cruciate ligament (ACL) reconstruction are lacking. The purpose of this study was to compare the effects of muscle fatigue on trunk, pelvis and lower limb kinematics and on lower limb muscle activation between male and female athletes who underwent ACL reconstruction. DESIGN: Cross-sectional study. SETTING: Laboratory setting. PARTICIPANTS: Fourteen recreational athletes (7 males and 7 females) with unilateral ACL reconstruction participated of this study...
February 5, 2018: Physical Therapy in Sport
María Laura Ponssa, Jéssica Fratani, Virginia Abdala
Anurans are characterized by their saltatory mode of locomotion, which is associated with a specific morphology. The coordinated action of the muscles and bones of the pelvic girdle is key to the transmission of the force of the hindlimbs to the axial skeleton during jumping. Two features are critical for optimal locomotory performance: the cross-sectional area of muscle and the bone crest attachment sites. The first character is a proxy of the force exerted by the muscle, whereas the crests are muscle attachments sites related to muscle force...
March 8, 2018: Journal of Anatomy
Patrizio Sale, Emanuele F Russo, Alessandra Scarton, Rocco S Calabrò, Stefano Masiero, Serena Filoni
BACKGROUND: Wearable robots are people-oriented robots designed to be worn all day, thus helping in the daily activities. They can assist in walking, running, jumping higher or even lifting objects too heavy in normal conditions. AIM: The aim of this report was thus to investigate the change in gait pattern trough 3D gait analysis subjects with Spinal Cord Injury (PwSCI) that underwent an adaptive training with a wearable Exoskeletal Device (ESD). The change in the quality of life was also investigate together with the possibility to wear these devices all day, to improve the mobility...
March 7, 2018: European Journal of Physical and Rehabilitation Medicine
Gaia Grimaldi, Antonio Leo, Angela Nigro, Sandro Pace, Valeria Braccini, Emilio Bellingeri, Carlo Ferdeghini
Anisotropy effects on flux pinning and flux flow are strongly effective in cuprate as well as iron-based superconductors due to their intrinsically layered crystallographic structure. However Fe(Se,Te) thin films grown on CaF2 substrate result less anisotropic with respect to all the other iron based superconductors. We present the first study on the angular dependence of the flux flow instability, which occurs in the flux flow regime as a current driven transition to the normal state at the instability point (I*, V*) in the current-voltage characteristics...
March 7, 2018: Scientific Reports
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