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https://www.readbyqxmd.com/read/28630299/bacteria-mediated-hypoxia-functions-as-a-signal-for-mosquito-development
#1
Kerri L Coon, Luca Valzania, David A McKinney, Kevin J Vogel, Mark R Brown, Michael R Strand
Mosquitoes host communities of microbes in their digestive tract that consist primarily of bacteria. We previously reported that several mosquito species, including Aedes aegypti, do not develop beyond the first instar when fed a nutritionally complete diet in the absence of a gut microbiota. In contrast, several species of bacteria, including Escherichia coli, rescue development of axenic larvae into adults. The molecular mechanisms underlying bacteria-dependent growth are unknown. Here, we designed a genetic screen around E...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28630112/rapid-evolution-of-ovarian-biased-genes-in-the-yellow-fever-mosquito-aedes-aegypti
#2
Carrie A Whittle, Cassandra G Extavour
Males and females exhibit highly dimorphic phenotypes, particularly in their gonads, which is believed to be driven largely by differential gene expression. Typically, the protein sequences of genes upregulated in males, or male-biased genes, evolve rapidly as compared to female-biased and unbiased genes. To date, the specific study of gonad-biased genes remains uncommon in metazoans. Here, we identified and studied a total of 2,927, 2,013 and 4,449 coding-sequences (CDS) with ovary-biased, testis-biased and unbiased expression respectively in the yellow-fever mosquito Aedes aegypti The results showed that ovary-biased and unbiased CDS had higher nonsynonymous to synonymous substitution rates (dN/dS) and lower optimal codon usage (those codons that promote efficient translation) than testis-biased genes...
June 19, 2017: Genetics
https://www.readbyqxmd.com/read/28630001/host-influence-in-the-genomic-composition-of-flaviviruses-a-multivariate-approach
#3
Diego Simón, Alvaro Fajardo, Martín Sóñora, Adriana Delfraro, Héctor Musto
Flaviviruses present substantial differences in their host range and transmissibility. We studied the evolution of base composition, dinucleotide biases, codon usage and amino acid frequencies in the genus Flavivirus within a phylogenetic framework by principal components analysis. There is a mutual interplay between the evolutionary history of flaviviruses and their respective vectors and/or hosts. Hosts associated to distinct phylogenetic groups may be driving flaviviruses at different pace and through various sequence landscapes, as can be seen for viruses associated with Aedes or Culex spp...
June 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28628464/early-evidence-for-zika-virus-circulation-among-aedes-aegypti-mosquitoes-rio-de-janeiro-brazil
#4
Tania Ayllón, Renata de Mendonça Campos, Patrícia Brasil, Fernanda Cristina Morone, Daniel Cardoso Portela Câmara, Guilherme Louzada Silva Meira, Egbert Tannich, Kristie Aimi Yamamoto, Marilia Sá Carvalho, Renata Saraiva Pedro, Jonas Schmidt-Chanasit, Daniel Cadar, Davis Fernandes Ferreira, Nildimar Alves Honório
During 2014-2016, we conducted mosquito-based Zika virus surveillance in Rio de Janeiro, Brazil. Results suggest that Zika virus was probably introduced into the area during May-November 2013 via multiple in-country sources. Furthermore, our results strengthen the hypothesis that Zika virus in the Americas originated in Brazil during October 2012-May 2013.
August 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28627853/determinants-of-outbreaks-of-emerging-infectious-diseases-the-case-of-chikungunya-in-indian-ocean-2004-2007
#5
Antoine Flahault
Emerging outbreaks of arboviroses are most often tied to the convergence of a set of factors which have physical and environmental, genetic and biological, ecological, social, political and economic origins. Thirteen out of these factors are known as main determinants of emerging infectious disease outbreaks. This paper assesses the role of these factors from exploring the Chikungunya outbreak which occurred in Indian Ocean in 2004-2007, as case study. Chikungunya is an alphavirus borne and transmitted by Aedes aegypti and Aedes albopictus...
May 3, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28624875/first-record-of-aedes-koreicus-diptera-culicidae-in-slovenia
#6
Katja Kalan, Jana Šušnjar, Vladimir Ivović, Elena Buzan
The first record of Aedes koreicus was made in the village of Lovrenc na Dravskem Polju, north-eastern part of the country. The discovery of Ae. koreicus in various continental European countries motivated us to revise samples of the collected Aedes japonicus japonicus. We found Ae. koreicus in samples from 2013, where the larvae were misidentified as Ae. j. japonicus. The species was identified morphologically and molecularly. The first discovery of Ae. koreicus advocates an urgent need for a nationwide mosquito surveillance programme...
June 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28624720/retention-of-perampanel-in-adults-with-pharmacoresistant-epilepsy-at-a-single-tertiary-care-center
#7
Tim Wehner, Shahidul Mannan, Sanchit Turaga, Kirtana Vallabhaneni, Hao Meng Yip, Carys Wiggans, Rohit Shankar, John S Duncan, Josemir W Sander
RATIONALE: Observational data on antiepileptic drugs (AEDs) inform about their use in clinical practice. We describe our clinical experience with perampanel (PER) in a large UK tertiary epilepsy center. METHODS: Adults initiated on PER between October 2012 and March 2015 were followed until they discontinued PER or 10 September 2016. Data on epilepsy syndrome, duration, seizure types, concomitant and previous AED use, PER dosing, efficacy and side effects were recorded...
June 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623959/the-impact-of-wolbachia-infection-on-the-rate-of-vertical-transmission-of-dengue-virus-in-brazilian-aedes-aegypti
#8
Etiene Casagrande Pacidônio, Eric Pearce Caragata, Debora Magalhães Alves, João Trindade Marques, Luciano Andrade Moreira
BACKGROUND: Wolbachia pipientis is a common endosymbiotic bacterium of arthropods that strongly inhibits dengue virus (DENV) infection and transmission in the primary vector, the mosquito Aedes aegypti. For that reason, Wolbachia-infected Ae. aegypti are currently being released into the field as part of a novel strategy to reduce DENV transmission. However, there is evidence that DENV can be transmitted vertically from mother to progeny, and this may help the virus persist in nature in the absence of regular human transmission...
June 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28623755/effects-of-adjunctive-lacosamide-on-mood-and-quality-of-life-in-patients-with-epilepsy
#9
Luba Nakhutina, Saroj D Kunnakkat, Madeleine Coleman, Catherine Lushbough, Vanessa Arnedo, Nirali Soni, Arthur C Grant
We examined the effects of adjunctive lacosamide (LCM) on mood and quality of life (QOL) in adult patients with partial-onset seizures in a prospective, controlled, single-blind study. Patients in whom LCM was added to their AED regimen for clinical indications comprised the LCM group (n=18), while the control group (n=32) comprised patients on ≥2 AEDs with anticipated stable dosing for the duration of the study. Profile of Mood States (POMS) and QOLIE-89 were used to assess mood and QOL at enrollment and 12-16weeks later...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623754/quality-of-life-mood-and-seizure-control-in-patients-with-brain-tumor-related-epilepsy-treated-with-lacosamide-as-add-on-therapy-a-prospective-explorative-study-with-a-historical-control-group
#10
Marta Maschio, Alessia Zarabla, Andrea Maialetti, Alessandra Fabi, Antonello Vidiri, Veronica Villani, Diana Giannarelli
OBJECTIVE: Brain tumor-related epilepsy (BTRE) is often drug resistant and patients can be forced to take polytherapy that can adversely affect their quality of life (QoL). Lacosamide (LCM) is a new antiepileptic drug (AED) used as adjunctive therapy in patients with partial seizures with or without secondary generalization, with a favorable pharmacokinetic profile that seems to be effective and well tolerated. Therefore it represents a possible therapeutic choice for patients with BTRE...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28622547/co-morbidity-and-clinically-significant-interactions-between-antiepileptic-drugs-and-other-drugs-in-elderly-patients-with-newly-diagnosed-epilepsy
#11
Emmi Bruun, Lauri J Virta, Reetta Kälviäinen, Tapani Keränen
PURPOSE: A study was conducted to investigate the frequency of potential pharmacokinetic drug-to-drug interactions in elderly patients with newly diagnosed epilepsy. We also investigated co-morbid conditions associated with epilepsy. METHOD: From the register of Kuopio University Hospital (KUH) we identified community-dwelling patients aged 65 or above with newly diagnosed epilepsy and in whom use of the first individual antiepileptic drug (AED) began in 2000-2013 (n=529)...
June 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28619679/antiviral-activity-of-1-2-3-triazolo-4-5-d-pyrimidin-7-6h-ones-against-chikungunya-virus-targeting-the-viral-capping-nsp1
#12
Alba Gigante, Asier Gómez-SanJuan, Leen Delang, C Li, Oskía Bueno, Ana María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez
Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted to humans by Aedes mosquitoes. Since 2005, CHIKV has been spreading worldwide resulting in epidemics in Africa, the Indian Ocean islands, Asia and more recently in the Americas. CHIKV is thus considered as a global health concern. There is no specific vaccine or drug available for the treatment of this incapacitating viral infection. We previously identified 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective inhibitors of CHIKV replication and proposed the viral capping enzyme nsP1 as a target...
June 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28617865/a-human-genotyping-trial-to-estimate-the-post-feeding-time-from-mosquito-blood-meals
#13
Yuuji Hiroshige, Masaaki Hara, Atsushi Nagai, Tomoyuki Hikitsuchi, Mitsuo Umeda, Yumi Kawajiri, Koji Nakayama, Koichi Suzuki, Aya Takada, Akira Ishii, Toshimichi Yamamoto
Mosquitoes occur almost worldwide, and females of some species feed on blood from humans and other animals to support ovum maturation. In warm and hot seasons, such as the summer in Japan, fed mosquitoes are often observed at crime scenes. The current study attempted to estimate the time that elapsed since feeding from the degree of human DNA digestion in mosquito blood meals and also to identify the individual human sources of the DNA using genotyping in two species of mosquito: Culex pipiens pallens and Aedes albopictus...
2017: PloS One
https://www.readbyqxmd.com/read/28616642/-identification-of-common-locations-of-out-of-hospital-cardiac-arrests-in-a%C3%A2-german-metropolis
#14
C Hanefeld, F Rosbund, A Kloppe, C Kloppe
BACKGROUND: Most patients who suffer a sudden cardiac arrest initially have a shockable rhythm. Fast defibrillation and correctly performed cardiopulmonary resuscitation (CPR) are key factors for patient survival. These can be carried out by bystanders if an automated external defibrillator (AED) is available even in the absence of emergency services. AIM: The place and time of CPRs in a German city were investigated and the strategic placement of emergency medical services and AEDs necessary were evaluated...
June 14, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28616473/ten-years-of-the-tiger-aedes-albopictus-presence-in-australia-since-its-discovery-in-the-torres-strait-in-2005
#15
REVIEW
Andrew F van den Hurk, Jay Nicholson, Nigel W Beebe, Joe Davis, Odwell M Muzari, Richard C Russell, Gregor J Devine, Scott A Ritchie
The "Asian tiger mosquito", Aedes albopictus, is highly invasive, an aggressive biter and a major arbovirus vector. It is not currently present on mainland Australia despite being intercepted on numerous occasions at international ports and infesting the Torres Strait of Australia since at least 2004. In the current paper, we describe the invasion and current status of Ae. albopictus in the Torres Strait, as well as research conducted to assess the threat of this species becoming established in arbovirus transmission cycles on the Australian mainland...
December 2016: One Health
https://www.readbyqxmd.com/read/28615988/identification-and-control-of-an-isolated-but-intense-focus-of-lymphatic-filariasis-on-satawal-island-federated-states-of-micronesia-in-2003
#16
Moses Pretrick, Wayne Melrose, Jean-Paul Chaine, Deon Canyon, Jaime Carron, Patricia M Graves, Richard S Bradbury
BACKGROUND: There is very limited data available on the prevalence of Bancroftian filariasis in the Federated States of Micronesia (FSM). Considerable attempts to eliminate the disease had occurred in the Pacific region by the year 2003, and the prevalence in FSM was thought to be sufficiently low that the region was considered non-endemic. However, a survey conducted in 2003 on an isolated atoll of FSM, Satawal Island, challenged that assumption. METHODS: Participants on Satawal Island were recruited and their blood tested for Wuchereria bancrofti antigen by the filariasis immunochromatographic test (ICT) card and circulating microfilaria by Knott's concentration technique...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28615847/larvicidal-potency-of-marine-actinobacteria-isolated-from-mangrove-environment-against-aedes-aegypti-and-anopheles-stephensi
#17
S Balakrishnan, P Santhanam, M Srinivasan
The marine soil samples were collected from different locations of Parangipettai mangrove ecosystem, Vellar estuary, southeast coast of India. Totally 30 different marine actinobacteria were isolated by serial dilution plate technique on starch casein agar medium. The isolated actinobacteria were investigated for their larvicidal activity against Aedes aegypti and Anopheles stephensi mosquitoes. Streptomyces fungicidicus, S. griseus, S. albus, S. alboflavus and S. rochei were identified as potential biocide producers...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28615216/emergency-response-facilities-including-primary-and-secondary-prevention-strategies-across-79-professional-football-clubs-in-england
#18
Aneil Malhotra, Harshil Dhutia, Sabiha Gati, Tee-Joo Yeo, Gherardo Finnochiaro, Tracey Keteepe-Arachi, Thomas Richards, Mike Walker, Robin Birt, David Stuckey, Laurence Robinson, Maite Tome, Ian Beasley, Michael Papadakis, Sanjay Sharma
AIM: To assess the emergency response planning and prevention strategies for sudden cardiac arrest (SCA) across a wide range of professional football clubs in England. METHODS: A written survey was sent to all professional clubs in the English football league, namely the Premiership, Championship, League 1 and League 2. Outcomes included: (1) number of clubs performing cardiac screening and frequency of screening; (2) emergency planning and documentation; (3) automated external defibrillator (AED) training and availability; and (4) provision of emergency services at sporting venues...
June 14, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28614394/first-report-of-naturally-infected-aedes-aegypti-with-chikungunya-virus-genotype-ecsa-in-the-americas
#19
André Luis Costa-da-Silva, Rafaella Sayuri Ioshino, Vivian Petersen, Antonio Fernando Lima, Marielton Dos Passos Cunha, Michael R Wiley, Jason T Ladner, Karla Prieto, Gustavo Palacios, Danuza Duarte Costa, Lincoln Suesdek, Paolo Marinho de Andrade Zanotto, Margareth Lara Capurro
BACKGROUND: The worldwide expansion of new emergent arboviruses such as Chikungunya and Zika reinforces the importance in understanding the role of mosquito species in spreading these pathogens in affected regions. This knowledge is essential for developing effective programs based on species specificity to avoid the establishment of endemic transmission cycles sustained by the identified local vectors. Although the first autochthonous transmission of Chikungunya virus was described in 2014 in the north of Brazil, the main outbreaks were reported in 2015 and 2016 in the northeast of Brazil...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28612239/dengue-hemorrhagic-fever-a-state-of-the-art-review-focused-in-pulmonary-involvement
#20
REVIEW
Renata Rocha de Almeida, Bernardo Paim, Solange Artimos de Oliveira, Arthur Soares Souza, Antônio Carlos Portugal Gomes, Dante Luiz Escuissato, Gláucia Zanetti, Edson Marchiori
Dengue fever is an arboviral disease transmitted to humans through the bites of infected female Aedes mosquitoes. Dengue virus is a member of the Flaviviridae family, and human infection can be caused by any of the four antigenically distinct serotypes (DENV 1-4). The infection has become recognized as the most important and prevalent arboviral disease in humans, endemic in almost 100 countries worldwide. Nearly 3 billion people live in areas with transmission risk. Autochthonous transmission of the virus in previously disease-free areas, increased incidence in endemic areas, and epidemic resurgence in controlled regions could increase the risk of contracting more severe forms of the disease, such as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)...
June 13, 2017: Lung
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