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https://www.readbyqxmd.com/read/28217067/septo-optic-dysplasia-de-morsier-s-syndrome
#1
Pedro Reis, Joana Mourão
Septo-optic dysplasia (SOD)/de Morsier's syndrome is characterized by optic nerve hypoplasia, pituitary endocrine dysfunction, and midline brain abnormalities. Hypopituitarism, hypothyroidism, hypogonadism, and adrenal insufficiency can lead to severe hypoglycemia, adrenal crisis, seizures, and sudden death. Anesthetic management of SOD was associated with high perioperative mortality. A 9-year-old male child proposed for dental treatments/extractions. Medical history of SOD with hypopituitarism, hypothyroidism, and delayed psychomotor development was observed...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28126450/piper-sarmentosum-roxb-produces-antidepressant-like-effects-in-rodents-associated-with-activation-of-the-creb-bdnf-erk-signalling-pathway-and-reversal-of-hpa-axis-hyperactivity
#2
Qing Li, Fa-Lin Qu, Yue Gao, Yi-Ping Jiang, Khalid Rahman, Kuo-Hsiung Lee, Ting Han, Lu-Ping Qin
ETHNOPHARMACOLOGICAL RELEVANCE: There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. MATERIALS AND METHODS: In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice...
January 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28100016/validation-of-an-enzyme-immunoassay-and-comparison-of-fecal-cortisol-metabolite-levels-in-black-and-gold-howler-monkeys-alouatta-caraya-inhabiting-fragmented-and-continuous-areas-of-the-humid-chaco-region-argentina
#3
Verónica Inés Cantarelli, Maria Amparo Perez-Rueda, Martin M Kowalewski, Gabriela F Mastromonaco, Marina Flavia Ponzio
: In the last years, the study of how environmental stimuli influence the physiology and specifically the endocrinology of an organism became increasingly important, relying mainly on the quantification of glucocorticoids to monitor animal welfare. Most studies investigating cortisol levels in primates were focused on the impact of social stressors; however, a major concern for the conservation of howler monkeys is the increased habitat fragmentation led by the advancement of the agricultural frontier...
March 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28095431/hair-measurements-of-cortisol-dhea-and-dhea-to-cortisol-ratio-as-biomarkers-of-chronic-stress-among-people-living-with-hiv-in-china-known-group-validation
#4
Shan Qiao, Xiaoming Li, Samuele Zilioli, Zheng Chen, Huihua Deng, Juxian Pan, Weigui Guo
BACKGROUND: Existing literature suggests that endocrine measures, including the steroid hormones of cortisol and Dehydroepiandrosterone (DHEA), as well as the DHEA to cortisol ratio in the human hair can be used as promising biomarkers of chronic stress among humans. However, data are limited regarding the validity of these measures as biomarkers of chronic stress among people living with HIV (PLWH), whose endocrine system or hypothalamic pituitary adrenal (HPA) axis may be affected by HIV infection and/or antiretroviral therapy (ART) medications...
2017: PloS One
https://www.readbyqxmd.com/read/28043926/laparoscopic-versus-robotic-adrenalectomy-a-comprehensive-meta-analysis
#5
REVIEW
Konstantinos P Economopoulos, Konstantinos S Mylonas, Aliki A Stamou, Vasileios Theocharidis, Theodoros N Sergentanis, Theodora Psaltopoulou, Melanie L Richards
BACKGROUND: The benefit of robotic adrenalectomy (RA) compared to laparoscopic adrenalectomy (LA) is still debatable. The purpose of this paper was to systematically review and synthesize all available evidence comparing RA to LA so as to evaluate which procedure provides superior clinical outcomes. METHODS: A systematic literature search of PubMed and Scopus databases was performed with respect to the PRISMA statement (end-of-search date: January 31, 2016). Data on perioperative variables were extracted by three independent reviewers...
February 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28027768/the-evolution-of-radiation-dose-over-time-measurement-of-a-patient-cohort-undergoing-whole-body-examinations-on-three-computer-tomography-generations
#6
Roy P Marcus, Elise Koerner, Roland C Aydin, Dominik Zinsser, Tobias Finke, Christian J Cyron, Fabian Bamberg, Konstantin Nikolaou, Mike Notohamiprodjo
OBJECTIVES: To evaluate and compare the radiation dose and image quality of whole-body-CT (WBCT) performed on the 3rd-generation dual-source-CT (DSCT) with 2nd-generation DSCT and 64-slices-Single-Source-CT (SSCT) in a large patient cohort. MATERIAL AND METHODS: Using a monitoring and tracking software 1451, 747 and 1861 patients scanned with a one-spiral-thorax-abdomen-pelvis-CT-examination on a 3rd-, 2nd-generation DSCT and SSCT, respectively, were extracted from the PACS server...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27940099/a-novel-method-for-assessing-chronic-cortisol-concentrations-in-dogs-using-the-nail-as-a-source
#7
Z Mack, H B Fokidis
Cortisol, a glucocorticoid secreted in response to stress, is used to assess adrenal function and mental health in clinical settings. Current methods assess cortisol sources that reflect short-term secretion that can vary with current stress state. Here, we present a novel method for the extraction and quantification of cortisol from the dog nail using solid phase extraction coupled to enzyme-linked immunosorbent assay. Validation experiments demonstrated accuracy (r = 0.836, P < 0.001) precision (15.1% coefficients of variation), and repeatability (14...
November 17, 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27928506/get-the-most-out-of-blow-hormones-validation-of-sampling-materials-field-storage-and-extraction-techniques-for-whale-respiratory-vapour-samples
#8
Elizabeth A Burgess, Kathleen E Hunt, Scott D Kraus, Rosalind M Rolland
Studies are progressively showing that vital physiological data may be contained in the respiratory vapour (blow) of cetaceans. Nonetheless, fundamental methodological issues need to be addressed before hormone analysis of blow can become a reliable technique. In this study, we performed controlled experiments in a laboratory setting, using known doses of pure parent hormones, to validate several technical factors that may play a crucial role in hormone analyses. We evaluated the following factors: (i) practical field storage of samples on small boats during daylong trips; (ii) efficiency of hormone extraction methods; and (iii) assay interference of different sampler types (i...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27882133/effects-of-forced-swimming-stress-on-thyroid-function-pituitary-thyroid-stimulating-hormone-and-hypothalamus-thyrotropin-releasing-hormone-expression-in-adrenalectomy-wistar-rats
#9
Qiuyan Sun, Aihua Liu, Yanan Ma, Anyi Wang, Xinhong Guo, Weiping Teng, Yaqiu Jiang
In order to study the impact that is imposed on the hypothalamic-pituitary-thyroid (HPT) axis of adrenalectomy male Wistar rats by stress caused by swimming, the blood level of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH), the expression of TSHβ mRNA at the pituitary and thyrotropin releasing hormone (TRH) expression at the paraventricular nucleus (PVN) were measured. A total of 50 male Wistar rats of 6-8 weeks of age and with an average weight of 190-210 grams were randomly divided into the following two groups: The surgical (without adrenal glands) and non-surgical (adrenalectomy) group...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27845698/laparoscopic-surgery-in-great-adrenal-malignant-masses
#10
Miguel Ángel Arrabal-Polo, Paolo Fabiano, Almudena Moreno, María Carmen Cano-García, Jaime Jorge, Rafael Rosado
OBJECTIVE: The aim of this article is to describe the surgical technique of laparoscopic resection in malignant tumors greater than 10 cm. METHODS: We present two cases, a 63 year old woman with a left adrenal heterogeneous mass of 11 cm in maximum diameter and an 80 year old man with a left adrenal heterogeneous mass 13 cm in maximum diameter. In both cases excision was performed laparoscopically using 4 trocars and the Alexis® wound retractor for specimen extraction...
November 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27829577/chronic-early-life-stress-in-rat-pups-alters-basal-corticosterone-intestinal-permeability-and-fecal-microbiota-at-weaning-influence-of-sex
#11
Nabila Moussaoui, Jonathan P Jacobs, Muriel Larauche, Mandy Biraud, Mulugeta Million, Emeran Mayer, Yvette Taché
Background/Aims: Wistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal axis and impaired epithelial barrier at PND10 and a visceral hypersensitivity at adulthood. Little is known about the impact of early life stress on the offspring before adulthood and the influence of sex. We investigated whether male and female rats previously exposed to LNS displays at weaning altered corticosterone, intestinal permeability, and microbiota...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27821225/understanding-oral-stereotypies-in-calves-alternative-strategies-hypothalamic-pituitary-adrenal-axis-re-activity-and-gene-by-environment-interactions
#12
L E Webb, C G van Reenen, B Engel, H Berends, W J J Gerrits, E A M Bokkers
Stereotypies are used as indicators of poor animal welfare and it is, therefore, important to understand underlying factors mediating their development. In calves, two oral stereotypies, that is, tongue playing and object manipulation, result mostly from insufficient structure in the diet. Three hypotheses were studied: (1) oral stereotypies in calves are one of two alternative strategies, the alternative being hypo-activity; (2) stereotyping and non-stereotyping calves differ in terms of cortisol secretion; (3) oral stereotypy development in calves rests on a gene by environment interaction...
November 8, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27781326/organ-weights-and-ratios-for-postmortem-identification-of-fetal-growth-restriction-utility-and-confounding-factors
#13
J Man, J C Hutchinson, M Ashworth, I Jeffrey, A E Heazell, N J Sebire
OBJECTIVES: The postmortem fetal brain:liver weight ratio is commonly used as a marker of nutrition for diagnosis of fetal growth restriction (FGR). However, there are limited data regarding the effects of intrauterine retention, fetal maceration and postmortem interval on organ weights and their ratios at autopsy. Our aims were to examine the relationships between gestational-age-adjusted and sex-adjusted fetal organ weights at autopsy, cause of intrauterine death and effects of intrauterine retention, and to determine whether the brain:liver weight ratio is a reliable marker of FGR in intrauterine death...
October 25, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27764519/protective-effects-of-peel-and-seed-extracts-of-citrus-aurantium-on-glutamate-induced-cytotoxicity-in-pc12-cell-line
#14
A Hosseini, H R Sadeghnia, A Rajabian
Oxidative stress and apoptosis contribute to neuronal degeneration in many neurodegenerative diseases such as Alzheimer's disease. Glutamate is a major excitatory neurotransmitter in the central nervous system (CNS) and is considered responsible for the pathogenesis of many neurological disorders. Reactive oxygen species (ROS) production is thought to be involved in glutamate-induced apoptosis process. In this study, the neuroprotective effects of Citrus aurantium in the glutamate-induced rat's adrenal pheochromocytoma cell line (PC12 cells) were investigated...
2016: Folia Neuropathologica
https://www.readbyqxmd.com/read/27751870/diverse-action-of-lipoteichoic-acid-and-lipopolysaccharide-on-neuroinflammation-blood-brain-barrier-disruption-and-anxiety-in-mice
#15
Raphaela Mayerhofer, Esther E Fröhlich, Florian Reichmann, Aitak Farzi, Nora Kogelnik, Eleonore Fröhlich, Wolfgang Sattler, Peter Holzer
Microbial metabolites are known to affect immune system, brain, and behavior via activation of pattern recognition receptors such as Toll-like receptor 4 (TLR4). Unlike the effect of the TLR4 agonist lipopolysaccharide (LPS), the role of other TLR agonists in immune-brain communication is insufficiently understood. We therefore hypothesized that the TLR2 agonist lipoteichoic acid (LTA) causes immune activation in the periphery and brain, stimulates the hypothalamic-pituitary-adrenal (HPA) axis and has an adverse effect on blood-brain barrier (BBB) and emotional behavior...
February 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27751767/immunohistochemistry-of-aldosterone-synthase-leads-the-way-to-the-pathogenesis-of-primary-aldosteronism
#16
Koshiro Nishimoto, Minae Koga, Tsugio Seki, Kenji Oki, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Mitsuhide Naruse, Tomokazu Sakaguchi, Shinya Morita, Takeo Kosaka, Mototsugu Oya, Tadashi Ogishima, Masanori Yasuda, Makoto Suematsu, Yasuaki Kabe, Masao Omura, Tetsuo Nishikawa, Kuniaki Mukai
Our group previously purified human and rat aldosterone synthase (CYP11B2 and Cyp11b2, respectively) from their adrenals and verified that it is distinct from steroid 11β-hydroxylase (CYP11B1 or Cyp11b1), the cortisol- or corticosterone-synthesizing enzyme. We now describe their distributions immunohistochemically with specific antibodies. In rats, there is layered functional zonation with the Cyp11b2-positive zona glomerulosa (ZG), Cyp11b1-positive zona fasciculata (ZF), and Cyp11b2/Cyp11b1-negative undifferentiated zone between the ZG and ZF...
October 14, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27721543/anxiolytic-antidepressant-and-antistress-activities-of-the-aqueous-extract-of-cinnamomum-tamala-nees-and-eberm-in-rats
#17
Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh
OBJECTIVE: The current study was designed to explore anxiolytic, antidepressant, and antistress actions of Cinnamomum tamala (CT) leaves (aqueous extract) in rats. MATERIALS AND METHODS: Behavioral procedures of anxiety, depression, and stress were assessed in rats. CT (100, 200, and 400 mg/kg) was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.), and Withania somnifera (100 mg/kg, p...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27686043/psychosocial-influences-on-acceptability-and-feasibility-of-salivary-cortisol-collection-from-community-samples-of-children
#18
Eileen M Condon
Salivary cortisol is considered to be a safe and noninvasive measure of hypothalamic-pituitary-adrenal axis functioning, and is a commonly measured biomarker of the human stress response in pediatric research. However, cortisol is highly variable and sensitive to a wide range of factors, creating a challenge for reliable salivary cortisol collection in the community setting. Furthermore, the acceptability of salivary cortisol collection in community samples of children is largely unknown. The purpose of this integrative review was to investigate current evidence on the acceptability and feasibility of salivary cortisol collection in community samples of children...
December 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27678095/investigating-the-role-of-fetal-gene-expression-in-preterm-birth
#19
Neeta L Vora, Lisa Smeester, Kim Boggess, Rebecca C Fry
Second-trimester amniotic fluid supernatant (AFS) contains cell-free fetal RNA (cffRNA) transcripts that can provide information about fetal gene expression. In a retrospective case-control study, we measured second-trimester fetal gene expression using cffRNA extracted from AFS in women who had spontaneous preterm birth (sPTB) <34 weeks and in women who delivered >37 weeks. We extracted cffRNA from AFS of women with singletons who had second-trimester genetic amniocenteses. Twenty-one gravidas who had sPTB and 21 term controls were matched 1:1 for maternal age, fetal sex, race, gestational age (GA) at the time of amniocentesis, and medication exposure...
September 27, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27649611/hypericum-perforatum-l-treatment-restored-bone-mass-changes-in-swimming-stressed-rats
#20
Nikos Seferos, Loukas Petrokokkinos, Antonia Kotsiou, George Rallis, Christine Tesseromatis
UNLABELLED: Stress, via corticosteroids release, influences bone mass density. Hypericum perforatum (Hp) a traditional remedy possess antidepressive activity (serotonin reuptake inhibitor) and wound healing properties. Hp preparation contains mainly hypericin, hyperforin, hyperoside and flavonoids exerting oestrogen-mimetic effect. Cold swimming represents an experimental model of stress associating mental strain and corporal exhaustion. OBJECTIVES: This study investigates the Hp effect on femur and mandible bone mass changes in rats under cold forced swimming procedure...
2016: Stomatologija
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