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adrenal extract

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https://www.readbyqxmd.com/read/28433565/inhibitory-effects-of-pine-nodule-extract-and-its-component-sj-2-on-acetylcholine-induced-catecholamine-secretion-and-synthesis-in-bovine-adrenal-medullary-cells
#1
Xiaojia Li, Takafumi Horishita, Yumiko Toyohira, Hui Shao, Jie Bai, Haixia Bo, Xinbo Song, Shin Ishikane, Yukari Yoshinaga, Noriaki Satoh, Masato Tsutsui, Nobuyuki Yanagihara
Extract of pine nodules (matsufushi) formed by bark proliferation on the surface of trees of Pinus tabulaeformis or Pinus massoniana has been used as an analgesic for joint pain, rheumatism, neuralgia, dysmenorrhea and other complaints in Chinese traditional medicine. Here we report the effects of matsufushi extract and its components on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. We found that matsufushi extract (0.0003-0.005%) and its component, SJ-2 (5-hydroxy-3-methoxy-trans-stilbene) (0...
April 7, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28421812/the-frequency-of-incidental-findings-and-subsequent-evaluation-in-low-dose-ct-scans-for-lung-cancer-screening
#2
Lillie Morgan, Humberto Choi, Michal Reid, Ali Khawaja, Peter J Mazzone
RATIONALE: The USPSTF recommends lung cancer screening with low-dose chest CT scans (LDCT) for a well-defined high-risk population. Data on the frequency and impact of incidental findings on LDCT scans performed within a centralized lung cancer screening program has not been reported. OBJECTIVES: Previous studies have reported IFs in the setting of clinical trials. We present our findings in a real clinical setting where the decision to manage these findings may depend on factors that are not captured in a research trial such as disclosing IFs, patient preferences, severity of comorbidities, and physician expertise...
April 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28407855/corrigendum-to-reducing-treatments-in-cattle-superovulation-protocols-by-combining-a-pituitary-extract-with-a-5-hyaluronan-solution-is-it-able-to-diminish-activation-of-the-hypothalamic-pituitary-adrenal-axis-compared-to-the-traditional-protocol-theriogenology
#3
Andrea Biancucci, Tatiana Sbaragli, Antonella Comin, Lakamy Sylla, Maurizio Monaci, Tanja Peric, Giuseppe Stradaioli
No abstract text is available yet for this article.
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28393656/punicalagin-reduces-h2o2-induced-cytotoxicity-and-apoptosis-in-pc12-cells-by-modulating-the-levels-of-reactive-oxygen-species
#4
Maria Elisabetta Clementi, Giovambattista Pani, Beatrice Sampaolese, Giuseppe Tringali
BACKGROUND: Oxidative stress has long been linked to neuronal cell death in many neurodegenerative diseases. Antioxidant conventional supplements are poorly effective in preventing neuronal damage caused by oxidative stress due to their inability to cross the blood brain barrier. Hence the use of molecules extracted from plants and fruits such as phenolics, flavonoids, and terpenoids compounds constitute a new wave of antioxidant therapies to defend against free radicals. OBJECTIVE: In this study we examined the effects of punicalagin, a ellagitannin isolated from the pomegranate juice, on a rat adrenal pheochromocytoma cell line, treated with hydrogen peroxide, evaluating the viability, oxidation potential, mitochondrial function, and eventual apoptosis...
April 9, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28353251/proteomic-profiling-of-the-pituitary-gland-in-studies-of-psychiatric-disorders
#5
Divya Krishnamurthy, Hassan Rahmoune, Paul C Guest
Psychiatric disorders have been associated with perturbations of the hypothalamic-pituitary-adrenal axis. Therefore, proteomic studies of the pituitary gland have the potential to provide new insights into the underlying pathways affected in these conditions as well as identify new biomarkers or targets for use in developing improved medications. This chapter describes a protocol for preparation of pituitary protein extracts followed by characterization of the pituitary proteome by label-free liquid chromatography-tandem mass spectrometry in expression mode (LC-MS(E))...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28342428/revealing-the-influence-of-glucocorticoid-treatment-on-the-excretion-of-anabolic-androgenic-steroids-in-horses-through-in-vitro-digestive-simulations-and-an-in-vivo-case-study
#6
Anneleen Decloedt, Sander Damen, Lynn Vanhaecke
Anabolic-androgenic steroids (AAS) are strictly forbidden in equine sports because of their stimulating effect on muscle growth and performance. Nevertheless, low levels of AAS have been found in some horses, untreated with AAS. Glucocorticoids (GC), used as an anti-inflammatory therapy and structurally related to AAS, might play a role in this phenomenon. In order to unravel this possible correlation the influence of glucocorticoid treatment on the excretion of AAS was studied both in vivo and in vitro. In vivo effects were investigated by analysing urine samples collected from a gelding treated with betamethasone...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28341876/consumption-of-green-tea-epigallocatechin-3-gallate-enhances-systemic-immune-response-antioxidative-capacity-and-hpa-axis-functions-in-aged-male-swiss-albino-mice
#7
Rohit Sharma, Anamika Sharma, Amita Kumari, Pankaj Markand Kulurkar, Rajneesh Raj, Ashu Gulati, Yogendra S Padwad
The present investigation assessed the potential of green tea phytochemical epigallocatechin-3-gallate (EGCG) in alleviating age-associated aberrations in immunity, hypothalamus-pituitary-adrenal (HPA) axis and redox homeostasis using 16 months old male Swiss albino mice. Four groups of animals (n = 6 per group) were supplemented with either aqueous EGCG at 25, 50 and 100 mg/kg/animal or vehicle control for 6 weeks. A concurrent analysis of CD4(+) and CD8(+) lymphocytes in splenocytes, differential leucocyte population, T cell differentiation markers in peripheral blood mononuclear cells (PBMCs), neutrophil functions, immunoglobulins profile in intestine, circulatory HPA axis hormonal levels as well as inflammatory and oxidative stress in the liver was performed...
March 24, 2017: Biogerontology
https://www.readbyqxmd.com/read/28328677/genitourinary-injuries-following-traffic-accidents-analysis-of-a-registry-of-162-690-victims
#8
Jean E Terrier, P Paparel, B Gadegbeku, Alain Ruffion, Lawrence C Jenkins, Amina N'Diaye
BACKGROUND: Traffic accidents are the most frequent cause of genitourinary injuries (GUI). Kidney injuries following trauma have been well described. However, there exists a paucity of data on other traumatic genitourinary injuries following traffic accidents. The objective of this study was to analyze the frequency and type of all genitourinary injuries, by user category, following traffic accidents. METHODS: Patient cases were extracted from the trauma registry of the French department of Rhone from 1996 to 2013...
March 21, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28323049/sutherlandia-frutescens-modulates-adrenal-hormone-biosynthesis-displays-anti-mineralocorticoid-and-serga-properties-acting-as-a-dissociated-glucocorticoid
#9
C A Sergeant, D Africander, P Swart, A C Swart
ETHNOPHARMACOLOGICAL RELEVANCE: Sutherlandia frutescens is a traditional African medicinal plant used in the treatment of stress and anxiety, while also exhibiting anti-inflammatory properties. AIM OF STUDY: The study aimed at linking anti-stress and anti-inflammatory properties of S. frutescens to its influence on glucocorticoid biosynthesis and the inflammatory response via steroid receptor interaction. MATERIALS AND METHODS: The influence of S...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28314177/gintonin-attenuates-depressive-like-behaviors-associated-with-alcohol-withdrawal-in-mice
#10
Hyeon-Joong Kim, Sang-Deuk Park, Ra Mi Lee, Byung-Hwan Lee, Sun-Hye Choi, Sung-Hee Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Seung-Yeol Nah
BACKGROUND: Panax ginseng Meyer extracts have been used to improve mood and alleviate symptoms of depression. However, little is known about the extracts' active ingredients and the molecular mechanisms underlying their reported anti-depressive effects. METHODS: Gintonin is an exogenous lysophosphatidic acid (LPA) receptor ligand isolated from P. ginseng. BON cells, an enterochromaffin cell line, and C57BL/6 mice were used to investigate whether gintonin stimulates serotonin release...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28289937/diagnostic-accuracy-of-virtual-non-contrast-enhanced-dual-energy-ct-for-diagnosis-of-adrenal-adenoma-a-systematic-review-and-meta-analysis
#11
Michael J Connolly, Matthew D F McInnes, Mohamed El-Khodary, Trevor A McGrath, Nicola Schieda
OBJECTIVE: To compare the diagnostic accuracy of dual-energy (DE) virtual non-contrast computed tomography (vNCT) to non-contrast CT (NCT) for the diagnosis of adrenal adenomas. METHODS: Search of multiple databases and grey literature was performed. Two reviewers independently applied inclusion criteria and extracted data. Risk of bias was assessed using QUADAS-2. Summary estimates of diagnostic accuracy were generated and sources of heterogeneity were assessed...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28284037/a-novel-dax-1-mutation-in-two-male-siblings-presenting-with-precocious-puberty-and-late-onset-hypogonadotropic-hypogonadism
#12
Yanxia Liu, Jinlei Yuan, Huijuan Zhang, Yanyan Jiang, Guijun Qin
Background The DAX-1 gene is associated with X-linked adrenal hypoplasia congenita (AHC). Our objective was to compare the DAX-1 gene sequence of two male siblings exhibiting different clinical manifestations of AHC. Methods Clinical features were analyzed and laboratory data were collected from both siblings. Genomic DNA was extracted from the peripheral blood leukocytes of the siblings and their parents and the DAX-1 gene exons and intron-flanking regions were amplified by the polymerase chain reaction. The DAX-1 gene sequences were compared following sequencing...
March 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28273494/cortisol-as-a-predictor-of-psychological-therapy-response-in-anxiety-disorders-systematic-review-and-meta-analysis
#13
REVIEW
Susanne Fischer, Anthony J Cleare
BACKGROUND: Although psychotherapy generally is effective in anxiety disorders, many patients are treatment-resistant. At the same time, some patients with anxiety disorders show alterations in the hypothalamic-pituitary-adrenal (HPA) axis, one of the major stress-responsive systems. Since raised levels of the end product of the HPA axis, cortisol, adversely affect cognition, we hypothesised that more pronounced alterations in cortisol levels would be associated with a less favourable response to psychotherapy...
February 24, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28267642/fundamental-studies-of-adrenal-retinoid-x-receptor-protein-isoform-tissue-expression-subcellular-distribution-and-ligand-availability
#14
Behling Cheng, Fatema H Al-Shammari, Isra'a A Ghader, Fatima Sequeira, Jitendra Thakkar, Thazhumpal C Mathew
Adrenal gland reportedly expresses many nuclear receptors that are known to heterodimerize with retinoid-X-receptor (RXR) for functions, but the information regarding the glandular RXR is not adequate. Studies of rat adrenal homogenate by Western blotting revealed three RXR proteins: RXRα (55kDa), RXRβ (47kDa) and RXR (56kDa). RXRγ was not detectable. After fractionation, RXRα was almost exclusively localized in the nuclear fraction. In comparison, substantial portions of RXRβ and RXR were found in both nuclear and post-nuclear particle fractions, suggesting genomic and non-genomic functions...
March 3, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28256113/clinical-characteristics-of-patients-with-adrenal-insufficiency-in-a-general-hospital
#15
Ye Yeon Lee, Nan Hee Cho, Jong Won Lee, Nam Kyung Kim, Hye Soon Kim, Mi Kyung Kim
BACKGROUND: Adrenal insufficiency (AI) is a life-threatening disorder caused by the deficiency of adrenal steroid hormones. This retrospective cross-sectional study investigated the characteristics of patients with AI in Korea. METHODS: All consecutive patients with suspected AI who received care at a tertiary referral center in Korea in 2014 and underwent adrenocorticotropic hormone stimulation or insulin-tolerance testing were identified through a review of medical charts...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28237803/serotonin-mediated-modulation-of-acetylcholine-induced-intracellular-calcium-responses-in-chromaffin-cells-isolated-from-the-rat-adrenal-medulla
#16
Takuya Yokoyama, Yoshio Yamamoto, Tomoyuki Saino
We examined serotonin (5-HT)-mediated modulation of acetylcholine (ACh)-induced intracellular Ca(2+) ([Ca(2+)]i) responses in rat adrenal chromaffin cells using calcium imaging. 5-HT did not induce any [Ca(2+)]i response in clustered chromaffin cells. However, the magnitude of ACh-induced [Ca(2+)]i increases in the same specimens was inhibited in the presence of 5-HT. ACh-induced [Ca(2+)]i increases in chromaffin cells were also inhibited by the 5-HT1A receptor agonist, 8-hydroxy-2-(dipropylamino) tetralin hydrobromide, but were not changed by the 5-HT1B, 5-HT2, or 5-HT3 receptor agonists, CP93129, α-methyl-5-HT, or 1-(m-chlorophenyl) biguanide, respectively...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28217067/septo-optic-dysplasia-de-morsier-s-syndrome
#17
Pedro Reis, Joana Mourão
Septo-optic dysplasia (SOD)/de Morsier's syndrome is characterized by optic nerve hypoplasia, pituitary endocrine dysfunction, and midline brain abnormalities. Hypopituitarism, hypothyroidism, hypogonadism, and adrenal insufficiency can lead to severe hypoglycemia, adrenal crisis, seizures, and sudden death. Anesthetic management of SOD was associated with high perioperative mortality. A 9-year-old male child proposed for dental treatments/extractions. Medical history of SOD with hypopituitarism, hypothyroidism, and delayed psychomotor development was observed...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28126450/piper-sarmentosum-roxb-produces-antidepressant-like-effects-in-rodents-associated-with-activation-of-the-creb-bdnf-erk-signalling-pathway-and-reversal-of-hpa-axis-hyperactivity
#18
Qing Li, Fa-Lin Qu, Yue Gao, Yi-Ping Jiang, Khalid Rahman, Kuo-Hsiung Lee, Ting Han, Lu-Ping Qin
ETHNOPHARMACOLOGICAL RELEVANCE: There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. MATERIALS AND METHODS: In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice...
January 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28100016/validation-of-an-enzyme-immunoassay-and-comparison-of-fecal-cortisol-metabolite-levels-in-black-and-gold-howler-monkeys-alouatta-caraya-inhabiting-fragmented-and-continuous-areas-of-the-humid-chaco-region-argentina
#19
Verónica Inés Cantarelli, Maria Amparo Perez-Rueda, Martin M Kowalewski, Gabriela F Mastromonaco, Marina Flavia Ponzio
In the last years, the study of how environmental stimuli influence the physiology and specifically the endocrinology of an organism became increasingly important, relying mainly on the quantification of glucocorticoids to monitor animal welfare. Most studies investigating cortisol levels in primates were focused on the impact of social stressors; however, a major concern for the conservation of howler monkeys is the increased habitat fragmentation led by the advancement of the agricultural frontier. We compared fecal cortisol metabolite levels (FGCM) in howler monkeys (Alouatta caraya) living in fragmented and continuous forests of the Argentine humid Chaco region, throughout the warm season (spring-summer)...
March 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28095431/hair-measurements-of-cortisol-dhea-and-dhea-to-cortisol-ratio-as-biomarkers-of-chronic-stress-among-people-living-with-hiv-in-china-known-group-validation
#20
Shan Qiao, Xiaoming Li, Samuele Zilioli, Zheng Chen, Huihua Deng, Juxian Pan, Weigui Guo
BACKGROUND: Existing literature suggests that endocrine measures, including the steroid hormones of cortisol and Dehydroepiandrosterone (DHEA), as well as the DHEA to cortisol ratio in the human hair can be used as promising biomarkers of chronic stress among humans. However, data are limited regarding the validity of these measures as biomarkers of chronic stress among people living with HIV (PLWH), whose endocrine system or hypothalamic pituitary adrenal (HPA) axis may be affected by HIV infection and/or antiretroviral therapy (ART) medications...
2017: PloS One
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