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https://www.readbyqxmd.com/read/29908309/anti-inflammatory-and-antibacterial-effects-of-thymus-sipyleus-boiss-subsp-sipyleus-boiss-var-sipyleus-l-essential-oil-against-rhinosinusitis-pathogens
#1
Fatih Demirci, Nursenem Karaca, Mehmet Tekin, Betül Demirci
Thymus sipyleus BOISS. subsp. sipyleus BOISS. var. sipyleus L. of the Lamiaceae, locally known as thyme scented lemon, which is an endemic taxon collected from Sivas in Anatolia, was investigated in this study due to its folk medicine use against rhinosinusitis. The aromatic characteristics of the plant material gave the idea for the detailed evaluation of the volatiles and essential oil thereof. Consequently, the oil was obtained by Clevenger type hydrodistillation followed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography/mass spectrometry (GC/MS) analyses for phytochemical characterization...
June 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29884399/optimization-of-%C3%AE-cyclodextrin-based-extraction-of-antioxidant-and-anti-browning-activities-from-thyme-leaves-by-response-surface-methodology
#2
Leonardo Cristian Favre, Cristina Dos Santos, María Paula López-Fernández, María Florencia Mazzobre, María Del Pilar Buera
Thyme (Thymus vulgaris) has been demonstrated to extend the shelf-life of food products, being also a potential source of bioactive compounds. The aim of this research was to optimize the ultrasound assisted extraction employing β-cyclodextrin aqueous solutions as no-contaminant technology and Response Surface Methodology to obtain thyme extracts with the maximum antioxidant capacity. The optimal extraction conditions were: a solution of β-ciclodextrin 15 mM, an ultrasonic treatment time of 5.9 min at a temperature of 36...
November 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29883671/thymol-alleviates-lipopolysaccharide-stimulated-inflammatory-response-via-downregulation-of-rhoa-mediated-nf-%C3%AE%C2%BAb-signalling-pathway-in-human-peritoneal-mesothelial-cells
#3
Qinglian Wang, Fajuan Cheng, Ying Xu, Jing Zhang, Jianjun Qi, Xiang Liu, Rong Wang
Thymol is one of the most important dietary constituents in the thyme species and has been shown to possess anti-inflammatory properties both in vivo and in vitro. We investigated the protective effects of thymol on the lipopolysaccharide (LPS)-induced inflammatory responses in the human peritoneal mesothelial cell line (HMrSV5) to clarify the potential mechanism. HMrSV5 cells were stimulated with LPS in the presence or absence of thymol. Our results showed that thymol markedly suppressed the production of cytokines such as tumour necrosis factor α (TNF-α), interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1) and α-smooth muscle actin (α-SMA) in a dose-dependent manner...
June 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29849737/formulation-and-characterization-of-potential-antifungal-oleogel-with-essential-oil-of-thyme
#4
Giedre Kasparaviciene, Zenona Kalveniene, Alvydas Pavilonis, Ruta Marksiene, Jurgita Dauksiene, Jurga Bernatoniene
The aim of this research was to formulate oleogel with thyme essential oil with potential antimicrobial activity, design optimal formulation, and evaluate the influence of ingredients on texture parameters of preparation. Central composite design was applied to statistical optimization of colloidal silica and paraffin oil mixture for the modeling of oleogel delivery system. The influence of designed formulations on response variables (texture parameters), firmness, cohesiveness, consistency, and index of viscosity, was evaluated...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29842987/green-synthesis-and-characterizations-of-gold-nanoparticles-using-thyme-and-survey-cytotoxic-effect-antibacterial-and-antioxidant-potential
#5
Mona Hamelian, Kambiz Varmira, Hojat Veisi
Nowadays, green chemistry methods are noticeable for synthesis metal nanoparticles due to affordable, easy and high reaction rate. In the present study gold nanoparticles (Au NPs) were eco-friendly synthesized using Thyme extract at the room temperature for 30 min to provide non-toxic, which can be used for different applications. Identifying properties of synthesized gold nanoparticles was done by various analytical technique including UV-Vis absorption spectroscopy approved presence of Au NPs in the solution, the functional groups of Thyme extract in the reduction and capping process of Au NPs are determined by FT-IR, Crystalline with the fcc plane approved by X-ray diffraction (XRD) pattern, energy dispersive spectroscopy (EDS) determined existence of elements in the sample, surface morphology, diverse shapes and size of present Au NPs were showed by scanning electron microscopy (SEM), atomic force microscopy (AFM) and Transmission electron microscopy (TEM)...
May 19, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29808049/the-use-of-herbal-supplements-by-individuals-with-diabetes-mellitus
#6
Emine Karaman, Ozum Erkin, Simge Senman, Yasemin Yildirim
OBJECTIVE: To analyse the use of herbal supplements by individuals with diabetes mellitus. METHODS: This cross-sectional study was carried out in the endocrinology clinics of two hospitals in Izmir, Turkey, between June and August 2016. The sample consisted of diabetic patients. Data was collected through face-to-face interviews guided by a questionnaire. SPSS 17 was used to analyse the data. RESULTS: There were 455 subjects with a mean age of 47...
April 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29792579/effects-of-essential-oil-from-thymus-vulgaris-on-viability-and-inflammation-in-zebrafish-embryos
#7
Katherine M Polednik, Abby C Koch, Lisa K Felzien
Innate immunity provides the initial response against pathogens and includes the inflammatory response. Regulation of the initiation and duration of neutrophil and mononuclear cell influx during inflammation determines both the successfulness of pathogen elimination and the level of resulting tissue damage. Zebrafish embryos provide excellent opportunities to visualize the inflammatory response. Neutrophil granules may be stained with Sudan black, and variation in neutrophil counts may be used to monitor the level of the response...
May 24, 2018: Zebrafish
https://www.readbyqxmd.com/read/29786850/plasticizers-and-bpa-residues-in-tunisian-and-italian-culinary-herbs-and-spices
#8
Giuseppa Di Bella, Hedi Ben Mansour, Asma Ben Tekaya, Asma Beltifa, Angela Giorgia Potortì, Emanuele Saiya, Giovanni Bartolomeo, Giacomo Dugo, Vincenzo Lo Turco
In the present study, 18 plasticizers and residues in 10 different Tunisian and Italian culinary herbs and spices (black pepper, mint, caraway, coriander, oregano, rosemary, thyme, fennel, verbena, and laurel) were determined by GC/MS. Di-methylphthalate, di-(2-methylpropyl)adipate, di-n-butyladipate, di-propylphthalate, benzylbenzoate, di-phenylphthalate, and bisphenol A were lower than their LOQ in all 118 samples. Among the Tunisian samples, di-(2-ethylhexyl)phthalate was found in all types of samples and di-butylphthalate in 50% of types; all other phthalates were rarely dectected...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29785774/thymol-thyme-and-other-plant-sources-health-and-potential-uses
#9
REVIEW
Bahare Salehi, Abhay Prakash Mishra, Ila Shukla, Mehdi Sharifi-Rad, María Del Mar Contreras, Antonio Segura-Carretero, Hannane Fathi, Nafiseh Nasri Nasrabadi, Farzad Kobarfard, Javad Sharifi-Rad
Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. This plant, native to Mediterranean regions, is commonly used as a culinary herb and also with a long history of use for different medicinal purposes. Nowadays, thymol and thyme present a wide range of functional possibilities in pharmacy, food, and cosmetic industry...
May 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29784145/the-effect-of-the-use-of-thyme-honey-in-minimizing-radiation-induced-oral-mucositis-in-head-and-neck-cancer-patients-a-randomized-controlled-trial
#10
Melanie Charalambous, Vasilios Raftopoulos, Lefkios Paikousis, Nicos Katodritis, Ekaterini Lambrinou, Dimitrios Vomvas, Morpho Georgiou, Andreas Charalambous
PURPOSE: Radiation-induced oral mucositis is one of the main side effects during and after the treatment of head and neck cancer patients. The study was designed to provide evidence on the effectiveness of thyme honey on oral mucositis management. METHODS: This was a randomised controlled trial (RCT) with 72 head and neck cancer patients who were divided either to the intervention group (thyme honey rinses) or to the control group (saline rinses). Oral mucositis was assessed according to the Radiation Therapy Oncology Group (RTOC criteria), and assessments were performed weekly starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29777637/thymol-inhibits-oral-squamous-cell-carcinoma-growth-via-mitochondria-mediated-apoptosis
#11
Jorge J De La Chapa, Prajjal Kanti Singha, Debbie R Lee, Cara B Gonzales
BACKGROUND: Thymol is a Transient Receptor Potential Ankyrin Subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties; thus thymol is added to many commercially available products including Listerine mouthwash. Thymol is also cytotoxic to HL-60 (acute promyelotic leukemia) cells in vitro. Therefore, we evaluated the effects of thymol against oral squamous cell carcinoma (OSCC) and its anticancer mechanism-of-action...
May 19, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29771598/understanding-the-potential-benefits-of-thyme-and-their-derived-products-on-food-industry-and-health-from-extraction-of-high-added-value-compounds-to-the-evaluation-of-bioaccessibility-bioavailability-anti-inflammatory-and-antimicrobial-activities
#12
Jose M Lorenzo, Amin Mousavi Khaneghah, Mohsen Gavahian, Krystian Marszałek, Ismail Eş, Paulo E S Munekata, Isabel C F R Ferreira, Francisco J Barba
Natural bioactive compounds isolated from aromatic plants have been studied for centuries due to their unique characteristics that carry great importance in food, pharmaceutical, and cosmetic industry. For instance, several beneficial activities have been attributed to some specific compounds found in Thymus such as anti-inflammatory, antioxidant, antimicrobial and antiseptic properties. Moreover, these compounds are classified as Generally Recognized as Safe (GRAS). Conventional extraction processes of these compounds and their derived forms from thyme leaves are well established, however, they present some important drawbacks such as long extraction time, low yield, high solvent consumption and unfavorable effect on thermolabile compounds...
May 17, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29770558/pharmacokinetic-and-antimicrobial-activity-of-a-new-carvacrol-based-product-against-a-human-pathogen-campylobacter-jejuni
#13
Marion Allaoua, Pierre Etienne, Virginie Noirot, Jean-Luc Carayon, Nathan Téné, Elsa Bonnafé, Michel Treilhou
AIM: In vitro and in vivo studies were conducted to test a new carvacrol-based product designed to delay the carvacrol release so that it could reach the caeca of broiler chickens in order to control Campylobacter jejuni. METHODS AND RESULTS: Antimicrobial activity of carvacrol, a constituent of oregano and thyme essential oil, has been demonstrated against C. jejuni in vitro, and this compound was found beneficial for broiler growth. Here, we tested a new liquid formulation that did not change the antibacterial efficacy of carvacrol against C...
May 16, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29766004/oral-administration-of-zataria-multiflora-extract-decreases-il-17-expression-in-perennial-allergic-rhinitis
#14
Nazila Ariaee, Jalal Ghorbani, Maryam Panahi, Mojgan Mohamadi, Javad Asili, Alireza Ranjbar, Reza Farid Hoseini, Farahzad Jabbari
Background: Rhinitis, which occurs most commonly as allergic rhinitis and affects 20% of the world's population, is a major health care burden causing significant morbidity. Considering the high prevalence of allergic rhinitis and anti-inflammatory effects of thyme, a favorite condiment, we performed a randomized clinical trial to determine whether thyme can relieve allergic rhinitis symptoms and affect the expression of TH17- and T-regulatory cell- (Treg) related cytokines IL-17, TGF-β, FOXP3, and IL-10...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29744941/carvacrol-and-human-health-a-comprehensive-review
#15
REVIEW
Mehdi Sharifi-Rad, Elena Maria Varoni, Marcello Iriti, Miquel Martorell, William N Setzer, María Del Mar Contreras, Bahare Salehi, Azam Soltani-Nejad, Sadegh Rajabi, Mercedeh Tajbakhsh, Javad Sharifi-Rad
Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety...
May 9, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29738503/investigation-of-the-antifungal-activity-and-mode-of-action-of-thymus-vulgaris-citrus-limonum-pelargonium-graveolens-cinnamomum-cassia-ocimum-basilicum-and-eugenia-caryophyllus-essential-oils
#16
Katarzyna Gucwa, Sławomir Milewski, Tomasz Dymerski, Piotr Szweda
The antimicrobial activity of plant oils and extracts has been recognized for many years. In this study the activity of Thymus vulgaris , Citrus limonum , Pelargonium graveolens , Cinnamomum cassia , Ocimum basilicum , and Eugenia caryophyllus essential oils (EOs) distributed by Pollena Aroma (Nowy Dwór Mazowiecki, Poland) was investigated against a group of 183 clinical isolates of C. albicans and 76 isolates of C. glabrata . All of the oils exhibited both fungistatic and fungicidal activity toward C. albicans and C...
May 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29730748/the-safety-assessment-of-toxic-metals-in-commonly-used-pharmaceutical-herbal-products-and-traditional-herbs-for-infants-in-jordanian-market
#17
Ala A Alhusban, Samah A Ata, Sawsan A Shraim
The objective of this study was to assess the levels of contamination by toxic metals (Pb, Al, Ni, Cd and As) that may be present in 25 infant pharmaceutical herbal products and 15 traditional herbs in Jordan. Both products and medicinal herbs are currently prescribed by paediatricians. They are available as over-the-counter medicines and are sold the in herbal market, ensuring easy accessibility for parents. Inductively coupled plasma-optical emission spectroscopy (ICP-OES), with limit of detections (LODs) of 0...
May 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29729177/clinical-and-pathogenetic-features-of-nonalcoholic-steatohepatitis-for-comorbidity-with-bronchial-asthma-on-the-background-of-obesity
#18
Oksana S Khukhlina, Alona A Antoniv, Olha Ye Mandryk, Olha Yе Hryniuk, Svitlana V Kovalenko, Victoria Yu Drozd, Zoriana Ia Kotsiubiichuk
OBJECTIVE: Introduction: The comorbid flow of non-alcoholic steatohepatitis (NASH) and bronchial asthma (BA) on the background of obesity is often recently drawn to the attention of both practitioners and researchers . The aim of our study was to study the changes in the functional state of the liver and the dependence of the external respiration function in patients with non-alcoholic steatohepatitis in combination with bronchial asthma and obesity. PATIENTS AND METHODS: Materials and methods: The study was attended by 50 people aged from 30 to 50 years (average age 42 years), of which 40% were men and 60% women...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29724221/use-of-pinus-sylvestris-l-pinaceae-origanum-vulgare-l-lamiaceae-and-thymus-vulgaris-l-lamiaceae-essential-oils-and-their-main-components-to-enhance-itraconazole-activity-against-azole-susceptible-not-susceptible-cryptococcus-neoformans-strains
#19
Daniela Scalas, Narcisa Mandras, Janira Roana, Roberta Tardugno, Anna Maria Cuffini, Valeria Ghisetti, Stefania Benvenuti, Vivian Tullio
BACKGROUND: Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is a growing problem in health care. To date, there are very few molecules with any activity towards Cryptococcus neoformans, leading to heightened interest in finding new alternatives or adjuvants to conventional drugs for the treatment of mycosis caused by this yeast. Since the essential oils (EOs) are considered as a potential rich source of bioactive antimicrobial compounds, we evaluated the antifungal activity of Origanum vulgare (oregano), Pinus sylvestris (pine), and Thymus vulgaris (thyme red) EOs, and their components (α-pinene, carvacrol, thymol) compared with fluconazole, itraconazole, and voriconazole, against C...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29708847/preliminary-study-on-the-antibacterial-activity-of-essential-oils-alone-and-in-combination-with-gentamicin-against-extended-spectrum-%C3%AE-lactamase-producing-and-new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates
#20
Paweł Kwiatkowski, Agata Pruss, Bartłomiej Grygorcewicz, Bartosz Wojciuk, Barbara Dołęgowska, Stefania Giedrys-Kalemba, Ewa Kochan, Monika Sienkiewicz
AIM: The aim of the study was to investigate possible synergistic effects between several selected, commercially available essential oils and gentamicin against extended-spectrum β-lactamase (ESBL)-producing and New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae isolates. MATERIALS AND METHODS: ESBLs production was confirmed by double-disk synergy test. Isolates positive for blaNDM-1 gene were found among the tested strains. K. pneumoniae ATCC® BAA-1705™ strain was used as a control...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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