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https://www.readbyqxmd.com/read/28511981/role-of-cholinergic-receptors-in-memory-retrieval-depends-on-gender-and-age-of-memory
#1
Rashid Habiba, Mahboob Aamra, Ahmed Touqeer
The phenomenon of utilizing information acquired in the past to make decision and performance in present depends on memory retrieval, which is affected in retrograde amnesia. Role of cholinergic receptors in memory retrieval is not much explored. In this study we evaluated the gender specific role of cholinergic receptors, i.e. muscarinic and nicotinic receptors, in memory retrieval in young Balb/c mice. Acute (only one injection, 30minutes before test) and sub-chronic (five days) muscarinic blockade (using scopolamine=1mg/kg) before test impaired retrieval of contextual fear memory in male (31...
May 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28508173/neuroprotective-effects-of-lycium-barbarum-polysaccharide-on-focal-cerebral-ischemic-injury-in-mice
#2
Peng Zhao, Ru Zhou, Xiao-Yun Zhu, Gang Liu, Yu-Ping Zhao, Peng-Sheng Ma, Wei Wu, Yang Niu, Tao Sun, Yu-Xiang Li, Jian-Qiang Yu, Zhong-Ming Qian
Increasing evidence demonstrates inflammation contributes to neuronal death following cerebral ischemia. Lycium barbarum polysaccharide (LBP) has been reported to prevent scopolamine-induced cognitive and memory deficits. We recently indicated that LBP exerts neuroprotective effect against focal cerebral ischemic injury in mice via attenuating the mitochondrial apoptosis pathway. The aim of this study was to investigate the neuroprotective effects of LBP against the behavioral dysfunction induced by focal cerebral ischemia injury in mice...
May 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28500194/million-dollar-ride-crime-committed-during-involuntary-scopolamine-intoxication
#3
Sonja Reichert, Cassandra Lin, William Ong, Claudia Chon Him, Saadia Hameed
No abstract text is available yet for this article.
May 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28494565/-the-protection-of-hydrogen-rich-saline-on-a-rat-dry-eye-model-induced-by-scopolamine-hydrobromide
#4
Y Y Chu, N Hua, Y S Ru, S Z Zhao
Objective: To evaluate the effect of hydrogen-rich saline (HRS) on dry eye rats induced by subcutaneous injection of scopolamine hydrobromide. Methods: Experiment research. Thirty female Wistar rats at about six weeks old were randomly divided into the normal group, dry eye group, HRS eyedrops group, normal saline eyedrops group (NS), HRS intraperitoneal injection group and NS intraperitoneal injection group, with 5 rats in each group. The dry eye was induced by subcutaneous injection of scopolamine hydrobromide in the latter five groups...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28489007/-frequency-of-symptoms-and-drug-treatment-among-dying-patients-in-the-last-24-hours-of-life-at-landspitali-the-national-university-hospital-of-iceland-and-in-nursing-homes
#5
Svandis Iris Halfdanardottir, Kristin Lara Olafsdottir, Valgerdur Sigurdardottir
INTRODUCTION: The purpose of this study was to evaluate the frequency of 5 common symptoms and drug treatments prescribed and given in the last 24 hours of life in 11 medical units at Landspitali National University Hospital of Iceland (LUH) and in 7 nursing homes (NH). MATERIAL AND METHODS: Data was collected retrospectively from 232 charts of patients who died in 2012, using documentation in the Liverpool Care Pathway (LCP) and the medication management system...
May 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28484137/identification-of-datura-species-involved-in-a-food-poisoning-case-using-lc-ms-ms-and-dna-barcording
#6
Atsuko Ushiyama, Chie Akaboshi, Nobuhiko Ohsawa, Tomomi Shimizu, Yuki Matsushima, Hideaki Shimizu, Shigeki Hashiguchi
A food-poisoning case due to eating the roots of Datura occurred in Kawasaki City, Japan in 2014. The Datura plant was mistakenly collected instead of burdock in a domestic garden. The roots of these plants are quite similar to each other. We presumed that the specimen was the root of Datura, but it was difficult to classify it only from the morphology. Using LC-MS/MS, we detected atropine and scopolamine from the remaining plant specimen. Therefore, we applied the DNA barcoding method. The results showed that the specimen was classified into Solanaceae family, but not Asteraceae family...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28480424/cognitive-enhancing-properties-of-morinda-lucida-rubiaceae-and-peltophorum-pterocarpum-fabaceae-in-scopolamine-induced-amnesic-mice
#7
Elufioye Taiwo O, Hameed Halimah A
BACKGROUND: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of Morinda lucida (L) Rubiaceae and Peltophorum pterocarpum (DC) ex. K Heyne in scopolamine induced amnesic animals. MATERIALS AND METHODS: The anti-amnesic activity of the ethyl acetate extracts of Morinda lucida and Peltophorum pterocarpum at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28463798/gladiolus-dalenii-lyophilisate-reverses-scopolamine-induced-amnesia-and-reduces-oxidative-stress-in-rat-brain
#8
Gwladys Temkou Ngoupaye, David Bougolla Pahaye, Judith Ngondi, Fleur Clarisse Okomolo Moto, Elisabeth Ngo Bum
Learning and memory are the most important executive functions performed by the human brain, the loss of which is a prominent feature in dementia. Gladiolus dalenii is traditionally used to treat a number of illnesses such as epilepsy and schizophrenia in Cameroon. This study aims to investigate the anti-amnesia effect of Gladiolus dalenii in scopolamine-induced amnesia in rats and its possible antioxidant properties in this model. Morris water maze, novel object location and recognition tasks were used to assess spatial and working memory...
April 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28462450/oxidative-stress-contributes-to-status-epilepticus-associated-mortality
#9
Jennifer N Pearson-Smith, Li-Ping Liang, Shane D Rowley, Brian J Day, Manisha Patel
Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive. The aim of the current study was to determine if targeting oxidative stress with the catalytic antioxidant, AEOL10150, would reduce pilocarpine-induced mortality and attenuate neuronal death and neuroinflammation. We found that treatment with AEOL10150 in conjunction with scopolamine and diazepam following pilocarpine-induced SE was able to significantly reduce mortality compared to treatment with just scopolamine and diazepam...
May 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28458424/evaluation-of-neuroprotective-effect-of-quercetin-with-donepezil-in-scopolamine-induced-amnesia-in-rats
#10
Laxmi Adiveppa Pattanashetti, Ashok D Taranalli, Vinay Parvatrao, Rohit H Malabade, Dushyant Kumar
OBJECTIVE: The objective of this study was to evaluate the neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. MATERIALS AND METHODS: Five groups of adult male Wistar rats (12 months old) weighing 180-200 g (n = 6) were used. The normal control group received normal saline and test group animals were pretreated orally with quercetin (25 mg/kg), donepezil (3 mg/kg), and a combination of quercetin (25 mg/kg) with donepezil (3 mg/kg), respectively, dosed at every 24 h interval for 14 consecutive days, afterward amnesia was induced by scopolamine (3 mg/kg) on the 14(th) day through intraperitoneal route...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458136/design-synthesis-and-evaluation-of-scutellarein-o-acetamidoalkylbenzylamines-as-potential-multifunctional-agents-for-the-treatment-of-alzheimer-s-disease
#11
Zhipei Sang, Xiaoming Qiang, Yan Li, Rui Xu, Zhongcheng Cao, Qing Song, Ting Wang, Xiaoyu Zhang, Hongyan Liu, Zhenghuai Tan, Yong Deng
A series of scutellarein-O-acetamidoalkylbenzylamines derivatives were designed based on a multitarget-directed ligands strategy for the treatment of Alzheimer's disease. Among these compounds, compound T-22 demonstrated excellent acetylcholinesterase inhibitory, moderate inhibitory effects on self-induced Aβ1-42 aggregation, Cu(2+)-induced Aβ1-42 aggregation, human AChE-induced Aβ1-40 aggregation and disassembled Cu(2+)-induced aggregation of the well-structured Aβ1-42 fibrils, and also acted as potential antioxidant and biometals chelator...
April 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28449397/differential-proteome-profiling-in-the-hippocampus-of-amnesic-mice
#12
Meghraj Singh Baghel, Mahendra Kumar Thakur
Amnesia or memory loss is associated with brain aging and several neurodegenerative pathologies including Alzheimer's disease (AD). This can be induced by a cholinergic antagonist scopolamine but the underlying molecular mechanism is poorly understood. This study of proteome profiling in the hippocampus could provide conceptual insights into the molecular mechanisms involved in amnesia. To reveal this, mice were administered scopolamine to induce amnesia and memory impairment was validated by novel object recognition test...
April 27, 2017: Hippocampus
https://www.readbyqxmd.com/read/28446773/therapeutic-effects-of-anti-hmgb1-monoclonal-antibody-on-pilocarpine-induced-status-epilepticus-in-mice
#13
Li Fu, Keyue Liu, Hidenori Wake, Kiyoshi Teshigawara, Tadashi Yoshino, Hideo Takahashi, Shuji Mori, Masahiro Nishibori
Inflammatory processes in brain tissue have been described in human epilepsy of various etiologies and in experimental models of seizures. High mobility group box-1 (HMGB1) is now recognized as representative of damage-associated molecular patterns (DAMPs). In the present study, we focused on whether anti-HMGB1 antibody treatment could relieve status epilepticus- triggered BBB breakdown and inflammation response in addition to the seizure behavior itself. Pilocarpine and methyl-scopolamine were used to establish the acute seizure model...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442406/anti-amnesic-effect-of-extract-and-alkaloid-fraction-from-aerial-parts-of-peganum-harmala-on-scopolamine-induced-memory-deficits-in-mice
#14
Wei Liu, Yudan Zhu, Yongli Wang, Shenglan Qi, Yuwen Wang, Chao Ma, Shuping Li, Bo Jiang, Xuemei Cheng, Zhengtao Wang, Zhenyu Xuan, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Peganum harmala Linn (APP) is used as traditional medical herb for treatment of forgetfulness in Uighur medicine in China. But, the active ingredients and underlying mechanisms are unclear. AIM OF THE STUDY: The present study was undertaken to investigate the improvement effects of extract and alkaloid fraction from APP on scopolamine-induced cognitive dysfunction and to elucidate their underlying mechanisms of action, and to support its folk use with scientific evidence, and lay a foundation for its further researches...
April 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28442362/blockade-of-muscarinic-acetylcholine-receptors-in-the-ventral-tegmental-area-blocks-the-acquisition-of-reward-related-learning
#15
E Galaj, R Nisanov, R Ranaldi
In the present study we investigated whether stimulation of muscarinic acetylcholine (mACh) receptors in the ventral tegmental area (VTA) plays a role in the acquisition of food-based conditioned approach learning. Rats were exposed to 3 (in Experiment 1) or 7 (in Experiment 2) conditioning sessions in which 30, randomly presented light (CS) presentations were paired with delivery of food pellets (US), followed by one session with no light or food and finally one CS-only test session with only light stimulus presentations...
April 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28442355/effects-of-muscarinic-receptor-antagonists-on-cocaine-discrimination-in-wild-type-mice-and-in-muscarinic-receptor-m1-m2-and-m4-receptor-knockout-mice
#16
Lauren Joseph, Morgane Thomsen
Muscarinic M1/M4 receptor stimulation can reduce abuse-related effects of cocaine and may represent avenues for treating cocaine addiction. Muscarinic antagonists can mimic and enhance effects of cocaine, including discriminative stimulus (S(D)) effects, but the receptor subtypes mediating those effects are not known. A better understanding of the complex cocaine/muscarinic interactions is needed to evaluate and develop potential muscarinic-based medications. Here, knockout mice lacking M1, M2, or M4 receptors (M1(-/-), M2(-/-), M4(-/-)), as well as control wild-type mice and outbred Swiss-Webster mice, were trained to discriminate 10mg/kg cocaine from saline...
April 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28441078/comparison-of-0-3-hypotonic-and-isotonic-sodium-hyaluronate-eye-drops-in-the-treatment-of-experimental-dry-eye
#17
Ying Li, Lian Cui, Hyo Seok Lee, Yeon Soo Kang, Won Choi, Kyung Chul Yoon
PURPOSE: To compare the efficacy of 0.3% hypotonic and isotonic sodium hyaluronate (SH) eye drops in the treatment of experimental dry eye. METHODS: Experimental dry eye was established in female C57BL/6 mice by subcutaneous scopolamine injection and an air draft. The mice were divided into three groups (n = 15): control, preservative-free 0.3% isotonic SH, and preservative-free 0.3% hypotonic SH. The tear volume, tear film break-up time, and corneal fluorescein staining scores were measured 5 and 10 days after treatment...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28419244/resolvin-d1-and-d2-reverse-lipopolysaccharide-induced-depression-like-behaviors-through-the-mtorc1-signaling-pathway
#18
Satoshi Deyama, Yuka Ishikawa, Kotomi Yoshikawa, Kento Shimoda, Soichiro Ide, Masamichi Satoh, Masabumi Minami
Background: Resolvin D1 (RvD1) and D2 (RvD2) are bioactive lipid mediators that are generated from docosahexaenoic acid (DHA). Although recent preclinical studies suggest that these compounds have antidepressant effects, their mechanisms of action remain unclear. Methods: We investigated mechanisms underlying the antidepressant effects of RvD1 and RvD2 in lipopolysaccharide (LPS; 0.8 mg/kg, i.p.)-induced depression model mice using a tail suspension test. Results: Intracerebroventricular (i...
April 13, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28417664/low-dose-systemic-scopolamine-disrupts-context-conditioning-in-rats
#19
Laura Luyten, Shauni Nuyts, Tom Beckers
Cholinergic neurotransmission plays a key role in learning and memory. Prior research with rats indicated that a low dose of pre-training scopolamine (0.1 mg/kg), a cholinergic receptor antagonist, did not affect cued fear conditioning, but did block renewal when injected before extinguishing a conditioned tone, opening up opportunities to pharmacologically improve exposure therapy for anxiety patients. Before translating these findings to the clinic, it is important to carefully examine how scopolamine affects contextual fear memories...
April 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28413325/the-psychopharmacological-activities-of-vietnamese-ginseng-in-mice-characterization-of-its-psychomotor-sedative-hypnotic-antistress-anxiolytic-and-cognitive-effects
#20
Irene Joy I Dela Peña, Hee Jin Kim, Chrislean Jun Botanas, June Bryan de la Peña, Thi Hong Van Le, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon Cheong
BACKGROUND: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. METHODS: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects...
April 2017: Journal of Ginseng Research
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