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https://www.readbyqxmd.com/read/29414555/specificity-of-electroclinical-features-in-the-diagnosis-of-ring-chromosome-20
#1
A B Gago-Veiga, R Toledano, I García-Morales, M A Pérez-Jiménez, J Bernar, A Gil-Nagel
BACKGROUND: Ring chromosome 20 (R20) syndrome is a chromosomal disorder characterized mainly by drug-resistant frontal lobe seizures, recurrent nonconvulsive status epilepticus (NCSE), and typical EEG features. The aim of this study was to investigate if this triad is common and specific to all patients with R20. METHODS: In this cross-sectional study (from 2000 to 2011), we selected patients who fulfilled at least two out of three criteria: drug-resistant frontal lobe seizures, recurrent NCSE, and characteristic electroencephalography (EEG) features...
February 2, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29354647/guidelines-and-recommendations-on-yeast-cell-death-nomenclature
#2
REVIEW
Didac Carmona-Gutierrez, Maria Anna Bauer, Andreas Zimmermann, Andrés Aguilera, Nicanor Austriaco, Kathryn Ayscough, Rena Balzan, Shoshana Bar-Nun, Antonio Barrientos, Peter Belenky, Marc Blondel, Ralf J Braun, Michael Breitenbach, William C Burhans, Sabrina Büttner, Duccio Cavalieri, Michael Chang, Katrina F Cooper, Manuela Côrte-Real, Vítor Costa, Christophe Cullin, Ian Dawes, Jörn Dengjel, Martin B Dickman, Tobias Eisenberg, Birthe Fahrenkrog, Nicolas Fasel, Kai-Uwe Fröhlich, Ali Gargouri, Sergio Giannattasio, Paola Goffrini, Campbell W Gourlay, Chris M Grant, Michael T Greenwood, Nicoletta Guaragnella, Thomas Heger, Jürgen Heinisch, Eva Herker, Johannes M Herrmann, Sebastian Hofer, Antonio Jiménez-Ruiz, Helmut Jungwirth, Katharina Kainz, Dimitrios P Kontoyiannis, Paula Ludovico, Stéphen Manon, Enzo Martegani, Cristina Mazzoni, Lynn A Megeney, Chris Meisinger, Jens Nielsen, Thomas Nyström, Heinz D Osiewacz, Tiago F Outeiro, Hay-Oak Park, Tobias Pendl, Dina Petranovic, Stephane Picot, Peter Polčic, Ted Powers, Mark Ramsdale, Mark Rinnerthaler, Patrick Rockenfeller, Christoph Ruckenstuhl, Raffael Schaffrath, Maria Segovia, Fedor F Severin, Amir Sharon, Stephan J Sigrist, Cornelia Sommer-Ruck, Maria João Sousa, Johan M Thevelein, Karin Thevissen, Vladimir Titorenko, Michel B Toledano, Mick Tuite, F-Nora Vögtle, Benedikt Westermann, Joris Winderickx, Silke Wissing, Stefan Wölfl, Zhaojie J Zhang, Richard Y Zhao, Bing Zhou, Lorenzo Galluzzi, Guido Kroemer, Frank Madeo
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-nition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria...
January 1, 2018: Microbial Cell
https://www.readbyqxmd.com/read/29348137/accuracy-of-the-compressed-sensing-accelerated-3d-flair-sequence-for-the-detection-of-ms-plaques-at-3t
#3
S Toledano-Massiah, A Sayadi, R de Boer, J Gelderblom, R Mahdjoub, S Gerber, M Zuber, M Zins, J Hodel
BACKGROUND AND PURPOSE: The use of 3D FLAIR improves the detection of brain lesions in MS patients, but requires long acquisition times. Compressed sensing reduces acquisition time by using the sparsity of MR images to randomly undersample the k-space. Our aim was to compare the image quality and diagnostic performance of 3D-FLAIR with and without compressed sensing for the detection of multiple sclerosis lesions at 3T. MATERIALS AND METHODS: Twenty-three patients with relapsing-remitting MS underwent both conventional 3D-FLAIR and compressed sensing 3D-FLAIR on a 3T scanner (reduction in scan time 1 minute 25 seconds, 27%; compressed sensing factor of 1...
January 18, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29329541/a-role-for-endothelial-nitric-oxide-synthase-in-intestinal-stem-cell-proliferation-and-mesenchymal-colorectal-cancer
#4
Jon Peñarando, Laura M López-Sánchez, Rafael Mena, Silvia Guil-Luna, Francisco Conde, Vanessa Hernández, Marta Toledano, Victoria Gudiño, Michela Raponi, Caroline Billard, Carlos Villar, César Díaz, José Gómez-Barbadillo, Juan De la Haba-Rodríguez, Kevin Myant, Enrique Aranda, Antonio Rodríguez-Ariza
BACKGROUND: Nitric oxide (NO) has been highlighted as an important agent in cancer-related events. Although the inducible nitric oxide synthase (iNOS) isoform has received most attention, recent studies in the literature indicate that the endothelial isoenzyme (eNOS) can also modulate different tumor processes including resistance, angiogenesis, invasion, and metastasis. However, the role of eNOS in cancer stem cell (CSC) biology and mesenchymal tumors is unknown. RESULTS: Here, we show that eNOS was significantly upregulated in VilCre ERT2 Apc fl/+ and VilCre ERT2 Apc fl/fl mouse intestinal tissue, with intense immunostaining in hyperproliferative crypts...
January 10, 2018: BMC Biology
https://www.readbyqxmd.com/read/29237460/validity-and-reliability-of-the-mexican-resilience-measurement-scale-in-families-of-children-with-chronic-conditions
#5
Filiberto Toledano-Toledano, José Moral de la Rubia, Laurie D McCubbin, Linda Liebenberg, Jesús Alejandro Vera Jiménez, Leonor Rivera-Rivera, Angie Hart, Leticia Andrea Barajas Nava, Marcela Salazar García, Silvia Martínez Valverde, Sofía Rivera Aragón, Concepción Sánchez Gómez, Laura Villavicencio Guzmán, Victor Granados García, Juan Garduño Espinosa
BACKGROUND: The resilience to face disease is a process of positive adaptation despite the loss of health. It involves developing vitality and skills to overcome the negative effects of adversity, risks, and vulnerability caused by disease. In Mexico, the Mexican Resilience Measurement Scale (RESI-M) has been validated with a general population and has a five-factor structure. However, this scale does not allow evaluation of resilience in specific subpopulations, such as caregivers. METHOD: This study investigated the psychometric properties of RESI-M in 446 family caregivers of children with chronic diseases...
December 13, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29185958/are-rheumatologists-adhering-to-the-concepts-window-of-opportunity-and-treat-to-target-earlier-and-more-intense-disease-modifying-anti-rheumatic-drug-treatment-over-time-in-patients-with-early-arthritis-in-the-pearl-study
#6
Esther Toledano, Ana M Ortiz, Jose Ivorra-Cortes, Nuria Montes, Amada Beltran, Luis Rodríguez-Rodriguez, Loreto Carmona, Isidoro González-Álvaro
OBJECTIVES: To analyse changes over time in the treatment with disease modifying anti-rheumatic drugs and biological therapies prescribed to patients from an early arthritis register and whether these changes had an impact on their outcome. METHODS: This was a longitudinal retrospective 2-year study based on data collected in the PEARL study. The population was clustered in three groups depending on year of symptoms onset (2000-2004, 2005-2009, 2010-2014). Intensity of disease-modifying anti-rheumatic drug treatment was calculated and the percentage of patients receiving biological therapy during the first 2-year follow-up was collected...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29069555/histopathological-findings-in-brain-tissue-obtained-during-epilepsy-surgery
#7
Ingmar Blumcke, Roberto Spreafico, Gerrit Haaker, Roland Coras, Katja Kobow, Christian G Bien, Margarete Pfäfflin, Christian Elger, Guido Widman, Johannes Schramm, Albert Becker, Kees P Braun, Frans Leijten, Johannes C Baayen, Eleonora Aronica, Francine Chassoux, Hajo Hamer, Hermann Stefan, Karl Rössler, Maria Thom, Matthew C Walker, Sanjay M Sisodiya, John S Duncan, Andrew W McEvoy, Tom Pieper, Hans Holthausen, Manfred Kudernatsch, H Joachim Meencke, Philippe Kahane, Andreas Schulze-Bonhage, Josef Zentner, Dieter H Heiland, Horst Urbach, Bernhard J Steinhoff, Thomas Bast, Laura Tassi, Giorgio Lo Russo, Cigdem Özkara, Buge Oz, Pavel Krsek, Silke Vogelgesang, Uwe Runge, Holger Lerche, Yvonne Weber, Mrinalini Honavar, José Pimentel, Alexis Arzimanoglou, Adriana Ulate-Campos, Soheyl Noachtar, Elisabeth Hartl, Olaf Schijns, Renzo Guerrini, Carmen Barba, Thomas S Jacques, J Helen Cross, Martha Feucht, Angelika Mühlebner, Thomas Grunwald, Eugen Trinka, Peter A Winkler, Antonio Gil-Nagel, Rafael Toledano Delgado, Thomas Mayer, Martin Lutz, Basilios Zountsas, Kyriakos Garganis, Felix Rosenow, Anke Hermsen, Tim J von Oertzen, Thomas L Diepgen, Giuliano Avanzini
BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%)...
October 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29056344/comprehensive-analysis-of-hypermutation-in-human-cancer
#8
Brittany B Campbell, Nicholas Light, David Fabrizio, Matthew Zatzman, Fabio Fuligni, Richard de Borja, Scott Davidson, Melissa Edwards, Julia A Elvin, Karl P Hodel, Walter J Zahurancik, Zucai Suo, Tatiana Lipman, Katharina Wimmer, Christian P Kratz, Daniel C Bowers, Theodore W Laetsch, Gavin P Dunn, Tanner M Johanns, Matthew R Grimmer, Ivan V Smirnov, Valérie Larouche, David Samuel, Annika Bronsema, Michael Osborn, Duncan Stearns, Pichai Raman, Kristina A Cole, Phillip B Storm, Michal Yalon, Enrico Opocher, Gary Mason, Gregory A Thomas, Magnus Sabel, Ben George, David S Ziegler, Scott Lindhorst, Vanan Magimairajan Issai, Shlomi Constantini, Helen Toledano, Ronit Elhasid, Roula Farah, Rina Dvir, Peter Dirks, Annie Huang, Melissa A Galati, Jiil Chung, Vijay Ramaswamy, Meredith S Irwin, Melyssa Aronson, Carol Durno, Michael D Taylor, Gideon Rechavi, John M Maris, Eric Bouffet, Cynthia Hawkins, Joseph F Costello, M Stephen Meyn, Zachary F Pursell, David Malkin, Uri Tabori, Adam Shlien
We present an extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load...
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29050419/successful-chilling-of-red-legged-partridge-alectoris-rufa-sperm-for-use-in-artificial-insemination
#9
J Santiago-Moreno, C Castaño, A Toledano-Díaz, M C Esteso, A López-Sebastián, S Villaverde-Morcillo, S G Dávila, M G Gil, E Blesbois
The fertilizing capacity of pure, fresh avian semen may disappear in just half an hour, hindering its successful use in artificial insemination (AI) projects. Longer storage requires the use of infra-physiological temperatures and of semen diluents that help preserve the spermatozoa but that do not interfere with their fertilizing capacity. This study examines the effect on sperm quality of storing red-legged partridge sperm for 3 h at 5°C with 2 different semen extenders: 1) a medium referred to as L&R-84, composed of sodium glutamate, glucose, magnesium acetate, potassium acetate, and polyvinylpyrrolidone, and 2) Lake 7...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28940401/social-cognition-in-autism-is-associated-with-the-neurodevelopment-of-the-posterior-superior-temporal-sulcus
#10
S Hotier, F Leroy, J Boisgontier, C Laidi, J-F Mangin, R Delorme, F Bolognani, C Czech, C Bouquet, E Toledano, M Bouvard, J Petit, M Mishchenko, M-A d'Albis, D Gras, A Gaman, I Scheid, M Leboyer, T Zalla, J Houenou
OBJECTIVE: The posterior superior temporal sulcus (pSTS) plays a critical role in the 'social brain'. Its neurodevelopment and relationship with the social impairment in autism spectrum disorders (ASD) are not well understood. We explored the relationship between social cognition and the neurodevelopment of the pSTS in ASD. METHOD: We included 44 adults with high-functioning ASD and 36 controls. We assessed their performances on the 'Reading the mind in the eyes' test (for 34 of 44 subjects with ASD and 30 of 36 controls), their fixation time on the eyes with eye tracking (for 35 of 44 subjects with ASD and 30 of 36 controls) and the morphology of the caudal branches of the pSTS (length and depth), markers of the neurodevelopment, with structural MRI...
November 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28931838/cerebellar-anatomical-alterations-and-attention-to-eyes-in-autism
#11
Charles Laidi, Jennifer Boisgontier, M Mallar Chakravarty, Sevan Hotier, Marc-Antoine d'Albis, Jean-Franc Ois Mangin, Gabriel A Devenyi, Richard Delorme, Federico Bolognani, Christian Czech, Céline Bouquet, Elie Toledano, Manuel Bouvard, Doriane Gras, Julie Petit, Marina Mishchenko, Alexandru Gaman, Isabelle Scheid, Marion Leboyer, Tiziana Zalla, Josselin Houenou
The cerebellum is implicated in social cognition and is likely to be involved in the pathophysiology of autism spectrum disorder (ASD). The goal of our study was to explore cerebellar morphology in adults with ASD and its relationship to eye contact, as measured by fixation time allocated on the eye region using an eye-tracking device. Two-hundred ninety-four subjects with ASD and controls were included in our study and underwent a structural magnetic resonance imaging scan. Global segmentation and cortical parcellation of the cerebellum were performed...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28860558/development-and-validation-of-a-multivariate-predictive-model-for-rheumatoid-arthritis-mortality-using-a-machine-learning-approach
#12
José M Lezcano-Valverde, Fernando Salazar, Leticia León, Esther Toledano, Juan A Jover, Benjamín Fernandez-Gutierrez, Eduardo Soudah, Isidoro González-Álvaro, Lydia Abasolo, Luis Rodriguez-Rodriguez
We developed and independently validated a rheumatoid arthritis (RA) mortality prediction model using the machine learning method Random Survival Forests (RSF). Two independent cohorts from Madrid (Spain) were used: the Hospital Clínico San Carlos RA Cohort (HCSC-RAC; training; 1,461 patients), and the Hospital Universitario de La Princesa Early Arthritis Register Longitudinal study (PEARL; validation; 280 patients). Demographic and clinical-related variables collected during the first two years after disease diagnosis were used...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807652/severity-indices-in-rheumatoid-arthritis-a-systematic-review
#13
Esther Toledano, M Jesús García de Yébenes, Isidoro González-Álvaro, Loreto Carmona
OBJECTIVE: To identify tools designed to evaluate the severity of patients with rheumatoid arthritis (RA) in order to use them in the investigation of prognostic markers in early arthritis. METHODS: We conducted a systematic review of studies that developed/validated an index for RA disease severity. They were analyzed using the COSMIN checklist to assess their methodological quality. In addition, all the variables included were evaluated for their clarity of definition, feasibility and probability of being present in each outcome during the first 2 years of the disease course...
August 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28653756/a-zinc-oxide-modified-hydroxyapatite-based-cement-facilitated-new-crystalline-stoichiometric-and-amorphous-apatite-precipitation-on-dentine
#14
M Toledano, M C Pérez-Álvarez, F S Aguilera, E Osorio, I Cabello, M Toledano-Osorio, R Osorio
AIM: To evaluate the remineralization ability of two endodontic sealer cements. METHODOLOGY: Mid-coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L(-1) ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite-based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24 h or 21 days...
June 27, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28621543/estimating-particulate-exposure-from-modern-municipal-waste-incinerators-in-great-britain
#15
Philippa Douglas, Anna Freni-Sterrantino, Maria Leal Sanchez, Danielle C Ashworth, Rebecca E Ghosh, Daniela Fecht, Anna Font, Marta Blangiardo, John Gulliver, Mireille B Toledano, Paul Elliott, Kees de Hoogh, Gary W Fuller, Anna L Hansell
Municipal Waste Incineration (MWI) is regulated through the European Union Directive on Industrial Emissions (IED), but there is ongoing public concern regarding potential hazards to health. Using dispersion modeling, we estimated spatial variability in PM10 concentrations arising from MWIs at postcodes (average 12 households) within 10 km of MWIs in Great Britain (GB) in 2003-2010. We also investigated change points in PM10 emissions in relation to introduction of EU Waste Incineration Directive (EU-WID) (subsequently transposed into IED) and correlations of PM10 with SO2, NOx, heavy metals, polychlorinated dibenzo-p-dioxins/furan (PCDD/F), polycyclic aromatic hydrocarbon (PAH) and polychlorinated biphenyl (PCB) emissions...
June 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28464396/asymmetric-effects-of-cooler-and-warmer-winters-on-beech-phenology-last-beyond-spring
#16
Constant Signarbieux, Ester Toledano, Paula Sanginés de Carcer, Yongshuo H Fu, Rodolphe Schlaepfer, Alexandre Buttler, Yann Vitasse
In temperate trees, the timings of plant growth onset and cessation affect biogeochemical cycles, water, and energy balance. Currently, phenological studies largely focus on specific phenophases and on their responses to warming. How differently spring phenology responds to the warming and cooling, and affects the subsequent phases, has not been yet investigated in trees. Here, we exposed saplings of Fagus sylvatica L. to warmer and cooler climate during the winter 2013-2014 by conducting a reciprocal transplant experiment between two elevations (1,340 vs...
May 2, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28437838/prognostic-relevance-of-mir-124-3p-and-its-target-tp53inp1-in-pediatric-ependymoma
#17
Yulia Margolin-Miller, Natalia Yanichkin, Keren Shichrur, Helen Toledano, Anat Ohali, Theophilos Tzaridis, Shalom Michowitz, Suzana Fichman-Horn, Meora Feinmesser, Stefan M Pfister, Hendrik Witt, Uri Tabori, Eric Bouffet, Vijay Ramaswamy, Cynthia Hawkins, Michael D Taylor, Isaac Yaniv, Smadar Avigad
Ependymoma is a malignant pediatric brain tumor, often incurable under the current treatment regimen. We aimed to evaluate the expression of microRNAs (miRs) in pediatric ependymoma tumors in an attempt to identify prognostic molecular markers which would lead to potential therapeutic targets. Following miR-array expression analysis, we focused on 9 miRs that correlated with relapse which were further validated by quantitative real-time PCR (qRT-PCR) in a cohort of 67 patients. Western blotting and immunohistochemistry were used to measure target protein expression in 20 and 34 tumor samples, respectively...
August 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28416376/seminal-plasma-removal-by-density-gradient-centrifugation-is-superior-for-goat-sperm-preservation-compared-with-classical-sperm-washing
#18
J Santiago-Moreno, M C Esteso, C Castaño, A Toledano-Díaz, J A Delgadillo, A López-Sebastián
Seminal plasma removal is routine in goat sperm cryopreservation protocols. The classical washing procedure designed to accomplish this usually leaves the pellet resulting from use of this procedure contaminated with dead sperm, debris, and cells other than sperm. This contamination negatively affects viability of sperm after cryopreservation. The present research was conducted to compare the effect on chilled and frozen-thawed goat sperm of the classical washing method to that of a selective washing method involving density gradient centrifugation (DGC)...
April 9, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28394230/advanced-mri-techniques-biomarkers-in-neuropsychiatric-lupus
#19
N Sarbu, P Toledano, A Calvo, E Roura, M I Sarbu, G Espinosa, X Lladó, R Cervera, N Bargalló
Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients without NPSLE and 20 healthy controls. We used visual scales to evaluate atrophy and white matter hyperintensities, voxel-based morphometry and Freesurfer to measure brain volume, plus diffusion-tensor imaging (DTI) to assess white matter (WM) and gray matter (GM) damage...
April 2017: Lupus
https://www.readbyqxmd.com/read/28376622/mechanical-loading-influences-the-viscoelastic-performance-of-the-resin-carious-dentin-complex
#20
Manuel Toledano, Raquel Osorio, Modesto T López-López, Fátima S Aguilera, Franklin García-Godoy, Manuel Toledano-Osorio, Estrella Osorio
The aim of this study was to evaluate the changes in the mechanical behavior and bonding capability of Zn-doped resin-infiltrated caries-affected dentin interfaces. Dentin surfaces were treated with 37% phosphoric acid (PA) followed by application of a dentin adhesive, single bond (SB) (PA+SB) or by 0.5 M ethylenediaminetetraacetic acid (EDTA) followed by SB (EDTA+SB). ZnO microparticles of 10 wt. % or 2 wt. % ZnCl2 was added into SB, resulting in the following groups: PA+SB, PA+SB-ZnO, PA+SB-ZnCl2, EDTA+SB, EDTA+SB-ZnO, EDTA+SB-ZnCl2...
April 4, 2017: Biointerphases
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