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R Palomba, A Parodi, M Evangelopoulos, S Acciardo, C Corbo, E de Rosa, I K Yazdi, S Scaria, R Molinaro, N E Toledano Furman, J You, M Ferrari, F Salvatore, E Tasciotti
Recent advances in the field of nanomedicine have demonstrated that biomimicry can further improve targeting properties of current nanotechnologies while simultaneously enable carriers with a biological identity to better interact with the biological environment. Immune cells for example employ membrane proteins to target inflamed vasculature, locally increase vascular permeability, and extravasate across inflamed endothelium. Inspired by the physiology of immune cells, we recently developed a procedure to transfer leukocyte membranes onto nanoporous silicon particles (NPS), yielding Leukolike Vectors (LLV)...
October 5, 2016: Scientific Reports
A Dupré, C Mousseaux, A Bouguerba, S Ayed, J Barchazs, M Boukari, D Goldgran-Toledano, C Bornstain, F Vincent
Whether it appears spontaneously or is induced by therapy, the tumor lysis syndrome is responsible for a massive release of ions and puric bases degradation of products in the circulation exceeding the renal excretion capacity. Some, such as uric acid, xanthine, and calcium phosphate, can precipitate in the renal tubules or parenchyma. It must be known to any practitioner supporting patients with hematologic malignancies, mainly high-grade but also some solid tumors. The 2015 publication of the British recommendations pertaining to patients suffering from hematological diseases should be broadcast...
September 19, 2016: La Revue de Médecine Interne
Isidoro González-Álvaro, Isabel Castrejón, Ana M Ortiz, Esther Toledano, Santos Castañeda, Alberto García-Vadillo, Loreto Carmona
OBJECTIVE: To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. METHODS: Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal [PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide [EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for low, moderate and high activity through receiver operating curve (ROC) analysis...
2016: PloS One
Andrew J Solomon, Dennis N Bourdette, Anne H Cross, Angela Applebee, Philip M Skidd, Diantha B Howard, Rebecca I Spain, Michelle H Cameron, Edward Kim, Michele K Mass, Vijayshree Yadav, Ruth H Whitham, Erin E Longbrake, Robert T Naismith, Gregory F Wu, Becky J Parks, Dean M Wingerchuk, Brian L Rabin, Michel Toledano, W Oliver Tobin, Orhun H Kantarci, Jonathan L Carter, B Mark Keegan, Brian G Weinshenker
OBJECTIVE: To characterize patients misdiagnosed with multiple sclerosis (MS). METHODS: Neurologists at 4 academic MS centers submitted data on patients determined to have been misdiagnosed with MS. RESULTS: Of 110 misdiagnosed patients, 51 (46%) were classified as "definite" and 59 (54%) "probable" misdiagnoses according to study definitions. Alternate diagnoses included migraine alone or in combination with other diagnoses 24 (22%), fibromyalgia 16 (15%), nonspecific or nonlocalizing neurologic symptoms with abnormal MRI 13 (12%), conversion or psychogenic disorders 12 (11%), and neuromyelitis optica spectrum disorder 7 (6%)...
September 27, 2016: Neurology
M A Burgos, D Mateos, V E Cachorro, C Toledano, A M de Frutos
To broaden the knowledge about desert dust (DD) aerosols in western Mediterranean Basin, their fingerprints on optical and microphysical properties are analyzed during DD episodes in the north-central plateau of the Iberian Peninsula between 2003 and 2014. Aerosol columnar properties obtained from the AErosol RObotic NETwork (AERONET), such as aerosol optical depth (AOD), Ångström exponent (AE), volume particle size distribution, volume concentration (VC), sphericity, single scattering albedo, among others, are analyzed in order to provide a general characterization, being some of them compared to particle mass surface concentrations PM10, PM2...
August 11, 2016: Science of the Total Environment
Irit Ben-Aharon, R Abir, G Perl, J Stein, G Gilad, H Toledano, S Elitzur, G Avrahami, A Ben-Haroush, G Oron, E Freud, D Kravarusic, M Ben-Arush, G Herzel, I Yaniv, S M Stemmer, B Fisch, S Ash
BACKGROUND: Current evidence indicates sub-optimal incidence of fertility preservation (FP) in eligible patients. We present herein our designated multidisciplinary program for FP in pediatric and adolescent population and present our data on FP in female patients. METHODS: Pediatric patients (age 0-18) who were candidate for highly gonadotoxic treatments were referred to FP program for a multidisciplinary discussion and gonadal risk-assessment followed by either oocyte cryopreservation or ovarian cryopreservation (OCP) for female patients, and sperm banking for male patients...
2016: BMC Cancer
Manolis Kogevinas, Mariona Bustamante, Esther Gracia-Lavedán, Ferran Ballester, Sylvaine Cordier, Nathalie Costet, Ana Espinosa, Regina Grazuleviciene, Asta Danileviciute, Jesus Ibarluzea, Maria Karadanelli, Stuart Krasner, Evridiki Patelarou, Euripides Stephanou, Adonina Tardón, Mireille B Toledano, John Wright, Cristina M Villanueva, Mark Nieuwenhuijsen
BACKGROUND: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. METHODS: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK...
November 2016: Epidemiology
Vered Shkalim Zemer, Helen Toledano, Shifra Ash, Eytan Cohen, Isaac Yaniv, Ian J Cohen
BACKGROUND: Little has been published in the medical literature on serum and cerebrospinal fluid (CSF) methotrexate (MTX) levels in children with brain tumors. METHODS: Matched 24-hour serum and CSF MTX levels were studied after 113 treatments in 35 brain tumors patients. RESULTS: A correlation between the 24-hour serum levels of MTX and MTX dosage was observed after 113 treatments in all 35 patients (r=0.39, P<0.001) but no statistical difference was found between CSF MTX levels in the irradiated and nonirradiated groups (P=0...
October 2016: Journal of Pediatric Hematology/oncology
J Pradiee, M C Esteso, C Castaño, A Toledano-Díaz, A Lopez-Sebastián, R Guerra, J Santiago-Moreno
This work examines the effectiveness of a TCG (Tris, citric acid, glucose, 6% egg yolk and 5% glycerol) and a TEST (TES, Tris, glucose, 6% egg yolk and 5% glycerol) sperm extender in the freezing of mouflon spermatozoa at slow cooling rates, using different pre-freezing equilibration times (2-3 hr). It also examines the tolerance of mouflon spermatozoa to different concentrations of cryoprotectants (5, 10, 20% glycerol; 5%, 10%, 20% dimethyl sulfoxide; 6% polyvinylpyrrolidone) and/or sucrose (100, 300, 500 mm)...
July 4, 2016: Andrologia
J Pradiee, E O'Brien, M C Esteso, C Castaño, A Toledano-Díaz, A Lopez-Sebastián, J L Marcos-Beltrán, R S Vega, F G Guillamón, E Martínez-Nevado, R Guerra, J Santiago-Moreno
The present study reports the effect of shortening the prefreezing equilibration time with glycerol on the quality of frozen-thawed ejaculated sperm from four Mediterranean mountain ungulates: Cantabrian chamois (Rupicapra pyrenaica), Iberian ibex (Capra pyrenaica), mouflon (Ovis musimon) and aoudad (Ammotragus lervia). Ejaculated sperm from these species were divided into two aliquots. One was diluted with either a Tris-citric acid-glucose based medium (TCG-glycerol; for chamois and ibex sperm) or a Tris-TES-glucose-based medium (TTG-glycerol; for mouflon and aoudad sperm), and maintained at 5°C for 3h prior to freezing...
August 2016: Animal Reproduction Science
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
J Poujade, R Sonneville, M Garrouste-Orgeas, B Souweine, E Azoulay, M Darmon, E Mariotte, L Argaud, F Barbier, D Goldgran-Toledano, G Marcotte, D Anne-Sophie, S Jamali, V Laurent, S Ruckly, J F Timsit
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
R Molinaro, C Corbo, J O Martinez, F Taraballi, M Evangelopoulos, S Minardi, I K Yazdi, P Zhao, E De Rosa, M B Sherman, A De Vita, N E Toledano Furman, X Wang, A Parodi, E Tasciotti
A multitude of micro- and nanoparticles have been developed to improve the delivery of systemically administered pharmaceuticals, which are subject to a number of biological barriers that limit their optimal biodistribution. Bioinspired drug-delivery carriers formulated by bottom-up or top-down strategies have emerged as an alternative approach to evade the mononuclear phagocytic system and facilitate transport across the endothelial vessel wall. Here, we describe a method that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles...
September 2016: Nature Materials
Lucia Jañez-Garcia, Federico Saenz-Frances, Jose M Ramirez-Sebastian, Nicolas Toledano-Fernandez, Maria Urbasos-Pascual, Luis Jañez-Escalada
OBJECTIVE: To apply a fully automated method to quantify the 3D structure of the bony nasolacrimal canal (NLC) from CT scans whereby the size and main morphometric characteristics of the canal can be determined. DESIGN: Cross-sectional study. SUBJECTS: 36 eyes of 18 healthy individuals. METHODS: Using software designed to detect the boundaries of the NLC on CT images, 36 NLC reconstructions were prepared. These reconstructions were then used to calculate NLC volume...
2016: PloS One
M I Domínguez-Mozo, E Toledano-Martínez, L Rodríguez-Rodríguez, M García-Montojo, R Alvarez-Lafuente, B Fernández-Gutiérrez
OBJECTIVES: To evaluate the presence of John Cunningham virus (JCV) DNA in patients with autoimmune rheumatic diseases (ARDs) treated with rituximab (RTX). METHOD: We assessed the JCV DNA levels in peripheral blood mononuclear cell (PBMC), serum, and urine samples by quantitative real-time polymerase chain reaction (qPCR) in a cohort of 42 ARD patients (20 of whom were being treated with RTX) and 42 healthy donors. Approximately 1 year later, we collected further samples from 32 of these 42 ARD patients, all of whom were being treated with RTX...
April 11, 2016: Scandinavian Journal of Rheumatology
A R Barbosa, K R Caleffi-Ferracioli, C Q F Leite, J C García-Ramos, Y Toledano-Magaña, L Ruiz-Azuara, V L D Siqueira, F R Pavan, R F Cardoso
New compounds with antituberculosis activity and their combination with classic drugs have been evaluated to determine possible interactions and antagonism. The aim of this study was to evaluate the in vitro activity of Casiopeínas® copper-based compounds (CasIIIia, CasIIIEa, and CasIIgly) alone and combined with isoniazid (INH), rifampicin, or ethambutol (EMB) against resistant and susceptible Mycobacterium tuberculosis. Seventeen clinical M. tuberculosis isolates (5 multi-drug resistant and 2 resistant to INH and/or EMB) were subjected to determination of the minimal inhibitory concentration (MIC) by the resazurin microtiter assay and combination assessment by the resazurin drug combination microtiter assay...
2016: Chemotherapy
Yi-Chun Chen, Børge Hamre, Øyvind Frette, Dennis Muyimbwa, Sandra Blindheim, Kerstin Stebel, Piotr Sobolewski, Carlos Toledano, Jakob J Stamnes
We present comparisons between estimates of the aerosol optical thickness and the Ångström exponent in Northern Norway and Svalbard based on data from AERONET (Aerosol Robotic Network) stations at Andenes (69.28°N, 16.01°E, 379 m altitude) and Hornsund (77.00°N, 15.56°E, 10 m altitude) for the period 2008-2013. The five/six-year annual mean values for the aerosol optical thickness at 500 nm τ(500) at Andenes and Hornsund both were 0.09. At Hornsund, there was less variation of the monthly mean value of τ(500) than at Andenes...
February 1, 2016: Applied Optics
R González-Vázquez, M G Córdova-Espinoza, A Escamilla-Gutiérrez, I Morales-Méndez, S A Ochoa-Pérez, F Armendáriz-Toledano, J Fonseca-Nájera, S Giono-Cerezo
BACKGROUND: Helicobacter pylori (H. pylori) is associated with gastroduodenal diseases. Virulence of clinical isolates is related to clinical outcome. Moreover, with microdiversity studies in clinical isolates from a single patient, but from a different origin (antrum or corpus), it is possible to demonstrate that there are simultaneous mixed infections. AIMS: To genotype H. pylori strains with multiplex PCR, according to their clinical virulence, and in this manner know the frequency of each genotype and relate it to clinical outcome in order to prevent the development of severe diseases...
January 2016: Revista de Gastroenterología de México
M Angeles Toledano-Medina, Jesús Pérez-Aparicio, Rafael Moreno-Rojas, Tania Merinas-Amo
Black garlic was processed at three different temperatures of heat treatment (72°, 75° and 78°C) and close to 90% of relative humidity. Two types of material source were used: whole bulbs and peeled cloves. Total soluble solids content (°Brix), pH, water activity (aw), browning intensive (L value), total polyphenol content, antioxidant capacity and total polyphenol index of the raw and heated garlic were determined. This study showed the changes occurring in the physicochemical and antioxidant properties of the garlic during the heat-treatment evolution...
May 15, 2016: Food Chemistry
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