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https://www.readbyqxmd.com/read/28433363/the-molecular-impact-of-omega-3-fatty-acids-on-hepatic-pro-inflammatory-cytokine-signaling
#1
George J Ventro, Yingkui Yang, Min Chen, Carroll M Harmon
PURPOSE: Parenteral nutrition associated liver disease (PNALD) develops in a subset of children receiving parenteral nutrition for intestinal failure. Omegaven™ is an omega-3 fatty acid (Ω3FA) lipid emulsion high in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) that can lessen PNALD. Inflammatory cytokines (IL-1, TNF-α, TGF-β) are elevated in PNALD and can decrease paraoxonase 1 protein expression (PON1). We sought to determine the effect of Omegaven™, EPA, and DHA on inflammatory cytokines TNF-α, IL-1, and TGF-β via ERK1/2 and p-Smad2/3 signaling pathways as well as the changes in intracellular PON1 protein expression as a potential mechanism explaining the protective effects of Omegaven™ and Ω3FA...
March 18, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28209417/influence-of-hospital-level-practice-patterns-on-variation-in-the-application-of-minimally-invasive-surgery-in-united-states-pediatric-patients
#2
Arianne T Train, Carroll M Harmon, David H Rothstein
BACKGROUND: Although disparities in access to minimally invasive surgery are thought to exist in pediatric surgical patients in the United States, hospital-level practice patterns have not been evaluated as a possible contributing factor. METHODS: Retrospective cohort study using the Kids' Inpatient Database, 2012. Odds ratios of undergoing a minimally invasive compared to open operation were calculated for six typical pediatric surgical operations after adjustment for multiple patient demographic and hospital-level variables...
February 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28157341/are-there-signatures-of-harmonic-oscillator-shells-far-from-stability-first-spectroscopy-of-110-zr
#3
N Paul, A Corsi, A Obertelli, P Doornenbal, G Authelet, H Baba, B Bally, M Bender, D Calvet, F Château, S Chen, J-P Delaroche, A Delbart, J-M Gheller, A Giganon, A Gillibert, M Girod, P-H Heenen, V Lapoux, J Libert, T Motobayashi, M Niikura, T Otsuka, T R Rodríguez, J-Y Roussé, H Sakurai, C Santamaria, N Shimizu, D Steppenbeck, R Taniuchi, T Togashi, Y Tsunoda, T Uesaka, T Ando, T Arici, A Blazhev, F Browne, A M Bruce, R Carroll, L X Chung, M L Cortés, M Dewald, B Ding, F Flavigny, S Franchoo, M Górska, A Gottardo, A Jungclaus, J Lee, M Lettmann, B D Linh, J Liu, Z Liu, C Lizarazo, S Momiyama, K Moschner, S Nagamine, N Nakatsuka, C Nita, C R Nobs, L Olivier, Z Patel, Zs Podolyák, M Rudigier, T Saito, C Shand, P-A Söderström, I Stefan, R Orlandi, V Vaquero, V Werner, K Wimmer, Z Xu
The first measurement of the low-lying states of the neutron-rich ^{110}Zr and ^{112}Mo was performed via in-beam γ-ray spectroscopy after one proton removal on hydrogen at ∼200  MeV/nucleon. The 2_{1}^{+} excitation energies were found at 185(11) keV in ^{110}Zr, and 235(7) keV in ^{112}Mo, while the R_{42}=E(4_{1}^{+})/E(2_{1}^{+}) ratios are 3.1(2), close to the rigid rotor value, and 2.7(1), respectively. These results are compared to modern energy density functional based configuration mixing models using Gogny and Skyrme effective interactions...
January 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/27551982/quintuplets-5-cases-of-nec-are-there-other-risk-factors
#4
Kavita Nadendla, Amelia Sutton, David Kelly, Reed Dimmitt, Linda Wilkinson, Carroll Harmon, Colin Martin
OBJECTIVE: To review a case of quintuplets with all babies developing necrotizing enterocolitis. METHODS: A retrospective study of preterm quintuplets all developing necrotizing enterocolitis. Clinical outcomes were reviewed. RESULTS: Quintuplets were born at 24 weeks gestation. Each baby developed NEC and was treated. One baby died. Currently the remaining 4 infants are on full enteral nutrition. CONCLUSION: Further studies are needed to better understand this emerging population of multiple birth pregnancy and the frequency of NEC development...
2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27521713/gallbladder-disease-in-children
#5
REVIEW
David H Rothstein, Carroll M Harmon
Biliary disease in children has changed over the past few decades, with a marked rise in incidence-perhaps most related to the parallel rise in pediatric obesity-as well as a rise in cholecystectomy rates. In addition to stone disease (cholelithiasis), acalculous causes of gallbladder pain such as biliary dyskinesia, also appear to be on the rise and present diagnostic and treatment conundrums to surgeons.
August 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27472474/biliary-dyskinesia-in-children-a-systematic-review
#6
Neha R Santucci, Paul E Hyman, Carroll M Harmon, Julie H Schiavo, Sunny Z Hussain
Cholecystectomy rates for biliary dyskinesia in children are rising in the United States, but not in other countries. Biliary dyskinesia is a validated functional gallbladder disorder in adults, requiring biliary colic in the diagnosis. In contrast, most studies in children require upper abdominal pain, absent gallstones on ultrasound, and an abnormal gallbladder ejection fraction (GBEF) on cholecystokinin-stimulated cholescintigraphy for diagnosis. We aimed to systematically review existing literature in biliary dyskinesia in children, determine the validity and reliability of diagnostic criteria, GBEF, and to assess outcomes following cholecystectomy...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27429076/changes-in-functional-mobility-and-musculoskeletal-pain-after-bariatric-surgery-in-teens-with-severe-obesity-teen-longitudinal-assessment-of-bariatric-surgery-labs-study
#7
Justin R Ryder, Nicholas M Edwards, Resmi Gupta, Jane Khoury, Todd M Jenkins, Sharon Bout-Tabaku, Marc P Michalsky, Carroll M Harmon, Thomas H Inge, Aaron S Kelly
IMPORTANCE: Severe obesity is associated with mobility limitations and higher incidence of multijoint musculoskeletal pain. It is unknown whether substantial weight loss improves these important outcomes in adolescents with severe obesity. OBJECTIVE: To examine the association of bariatric surgery with functional mobility and musculoskeletal pain in adolescents with severe obesity up to 2 years after surgery. DESIGN, SETTING, AND PARTICIPANTS: The Teen-Longitudinal Assessment of Bariatric Surgery Study is a prospective, multicenter, observational study, which enrolled 242 adolescents (≤19 years of age) who were undergoing bariatric surgery from March 2007 through February 2012 at 5 US adolescent bariatric surgery centers...
September 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27352106/advances-in-pediatric-surgical-education-a-critical-appraisal-of-two-consecutive-minimally-invasive-pediatric-surgery-training-courses
#8
Colin D Gause, Grace Hsiung, Ben Schwab, Matthew Clifton, Carroll M Harmon, Katherine A Barsness
BACKGROUND: Mandates for improved patient safety and increasing work hour restrictions have resulted in changes in surgical education. Educational courses increasingly must meet those needs. We sought to determine the experience, skill level, and the impact of simulation-based education (SBE) on two cohorts of pediatric surgery trainees. MATERIALS AND METHODS: After Institutional Review Board (IRB) exempt determination, a retrospective review was performed of evaluations for an annual advanced minimally invasive surgery (MIS) course over 2 consecutive years...
August 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27072665/molecular-impact-of-omega-3-fatty-acids-on-lipopolysaccharide-mediated-liver-damage
#9
George Ventro, Min Chen, Yingkui Yang, Carroll M Harmon
BACKGROUND: Growing evidence suggests that omega 3 fatty acid containing lipid emulsions have a beneficial effect on parenteral nutrition associated liver disease (PNALD). However, the cellular and molecular mechanisms responsible for this effect are unclear. In this study, we investigated whether Omegaven™ fish oil emulsion could inhibit lipopolysaccharidase (LPS) mediated liver damage. METHODS: We examined the effects of Omegaven™ and LPS alone and synergistically on hepatic paraoxonase 1 (PON1), a potent antioxidant protein, ERK1/2 activity, and TLR4 regulation...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27012861/repair-of-esophageal-atresia-with-proximal-fistula-using-endoscopic-magnetic-compression-anastomosis-magnamosis-after-staged-lengthening
#10
Robert M Dorman, Kaveh Vali, Carroll M Harmon, Mario Zaritzky, Kathryn D Bass
We describe the treatment of a patient with long-gap esophageal atresia with an upper pouch fistula, mircogastria and minimal distal esophageal remnant. After 4.5 months of feeding via gastrostomy, a proximal fistula was identified by bronchoscopy and a thoracoscopic modified Foker procedure was performed reducing the gap from approximately 7-5 cm over 2 weeks of traction. A second stage to ligate the fistula and suture approximate the proximal and distal esophagus resulted in a gap of 1.5 cm. IRB and FDA approval was then obtained for endoscopic placement of 10-French catheter mounted magnets in the proximal and distal pouches promoting a magnetic compression anastomosis (magnamosis)...
May 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/26911811/extracting-information-from-the-text-of-electronic-medical-records-to-improve-case-detection-a-systematic-review
#11
REVIEW
Elizabeth Ford, John A Carroll, Helen E Smith, Donia Scott, Jackie A Cassell
BACKGROUND: Electronic medical records (EMRs) are revolutionizing health-related research. One key issue for study quality is the accurate identification of patients with the condition of interest. Information in EMRs can be entered as structured codes or unstructured free text. The majority of research studies have used only coded parts of EMRs for case-detection, which may bias findings, miss cases, and reduce study quality. This review examines whether incorporating information from text into case-detection algorithms can improve research quality...
September 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/26544725/weight-loss-and-health-status-3-years-after-bariatric-surgery-in-adolescents
#12
MULTICENTER STUDY
Thomas H Inge, Anita P Courcoulas, Todd M Jenkins, Marc P Michalsky, Michael A Helmrath, Mary L Brandt, Carroll M Harmon, Meg H Zeller, Mike K Chen, Stavra A Xanthakos, Mary Horlick, C Ralph Buncher
BACKGROUND: Bariatric surgery is increasingly considered for the treatment of adolescents with severe obesity, but few prospective adolescent-specific studies examining the efficacy and safety of weight-loss surgery are available to support clinical decision making. METHODS: We prospectively enrolled 242 adolescents undergoing weight-loss surgery at five U.S. centers. Patients undergoing Roux-en-Y gastric bypass (161 participants) or sleeve gastrectomy (67) were included in the analysis...
January 14, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26520940/a-decade-spanning-high-resolution-asynchronous-optical-sampling-terahertz-time-domain-and-frequency-comb-spectrometer
#13
Jacob T Good, Daniel B Holland, Ian A Finneran, P Brandon Carroll, Matthew J Kelley, Geoffrey A Blake
We present the design and capabilities of a high-resolution, decade-spanning ASynchronous OPtical Sampling (ASOPS)-based TeraHertz Time-Domain Spectroscopy (THz-TDS) instrument. Our system employs dual mode-locked femtosecond Ti:Sapphire oscillators with repetition rates offset locked at 100 Hz via a Phase-Locked Loop (PLL) operating at the 60th harmonic of the ∼80 MHz oscillator repetition rates. The respective time delays of the individual laser pulses are scanned across a 12.5 ns window in a laboratory scan time of 10 ms, supporting a time delay resolution as fine as 15...
October 2015: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26488724/thoracoscopic-cdh-repair-a-survey-on-opinion-and-experience-among-ipeg-members
#14
Martin Lacher, Shawn D St Peter, Pablo Laje, Carroll M Harmon, Benno Ure, Joachim F Kuebler
BACKGROUND: Thoracoscopic repair of congenital diaphragmatic hernia (CDH) has become a popular approach. As there is an ongoing discussion on whether the benefits of the thoracoscopic repair outweigh the potential side effects, we aimed to investigate the opinion and experience of the members of the International Pediatric Endosurgery Group (IPEG) on this topic. MATERIALS AND METHODS: An online survey was conducted between October and December 2013 on behalf of the IPEG Research Committee...
November 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/26257068/recurrent-laryngeal-nerve-reinnervation-in-children-acoustic-and-endoscopic-characteristics-pre-intervention-and-post-intervention-a-comparison-of-treatment-options
#15
COMPARATIVE STUDY
Karen B Zur, Linda M Carroll
OBJECTIVES/HYPOTHESIS: To establish the benefit of ansa cervicalis-recurrent laryngeal nerve reinnervation (ANSA-RLN) for the management of dysphonia secondary to unilateral vocal cord paralysis (UVCP) in children. Children treated with ANSA-RLN for the management of dysphonia secondary to unilateral vocal fold immobility will have superior acoustic, perceptual, and stroboscopic outcomes compared to injection laryngoplasty and observation. STUDY DESIGN: Retrospective case-series chart review...
December 2015: Laryngoscope
https://www.readbyqxmd.com/read/26121438/diabetes-and-prediabetes-are-significantly-higher-in-morbidly-obese-children-compared-with-obese-children
#16
Matthew Propst, Caroline Colvin, Russell L Griffin, Bhuvana Sunil, Carroll M Harmon, Govardhana Yannam, Joffre E Johnson, Cody Brian Smith, Alan P Lucas, Benjamin Tuanama Diaz, Ambika P Ashraf
OBJECTIVE: The objective of this study was to examine the prevalence and characteristics of comorbidities in obese and morbidly obese children with a comparison between the 2 sets of children. METHODS: This was a retrospective electronic chart review of obese and morbidly obese children and adolescents as defined by body mass index. We evaluated medical history of comorbid conditions, medication use, and cardiovascular risk markers, including blood pressure, lipid profile, and glycosylated hemoglobin...
September 2015: Endocrine Practice
https://www.readbyqxmd.com/read/26026390/high-prevalence-of-nonalcoholic-fatty-liver-disease-in-adolescents-undergoing-bariatric-surgery
#17
MULTICENTER STUDY
Stavra A Xanthakos, Todd M Jenkins, David E Kleiner, Tawny W Boyce, Reena Mourya, Rebekah Karns, Mary L Brandt, Carroll M Harmon, Michael A Helmrath, Marc P Michalsky, Anita P Courcoulas, Meg H Zeller, Thomas H Inge
BACKGROUND & AIMS: Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort of adolescents undergoing bariatric surgery and the factors associated with it. METHODS: We enrolled 242 adolescents undergoing bariatric surgery between March 2007 and February 2012 at 5 tertiary care centers into a multicenter, prospective observational cohort study...
September 2015: Gastroenterology
https://www.readbyqxmd.com/read/25915190/musculoskeletal-pain-self-reported-physical-function-and-quality-of-life-in-the-teen-longitudinal-assessment-of-bariatric-surgery-teen-labs-cohort
#18
Sharon Bout-Tabaku, Marc P Michalsky, Todd M Jenkins, Amy Baughcum, Meg H Zeller, Mary L Brandt, Anita Courcoulas, Ralph Buncher, Michael Helmrath, Carroll M Harmon, Mike K Chen, Thomas H Inge
IMPORTANCE: Obesity is associated with chronic musculoskeletal pain and is a risk factor for disability and osteoarthritis. OBJECTIVES: To describe the prevalence, sites, and intensity of musculoskeletal pain in adolescents with severe obesity; to evaluate associations between musculoskeletal pain and self-reported physical function as well as weight-related quality of life; and to evaluate the association between musculoskeletal pain and high-sensitivity C-reactive protein level...
June 2015: JAMA Pediatrics
https://www.readbyqxmd.com/read/25730293/cardiovascular-risk-factors-in-severely-obese-adolescents-the-teen-longitudinal-assessment-of-bariatric-surgery-teen-labs-study
#19
Marc P Michalsky, Thomas H Inge, Mark Simmons, Todd M Jenkins, Ralph Buncher, Michael Helmrath, Mary L Brandt, Carroll M Harmon, Anita Courcoulas, Michael Chen, Mary Horlick, Stephen R Daniels, Elaine M Urbina
IMPORTANCE: Severe obesity is increasingly common in the adolescent population but, as of yet, very little information exists regarding cardiovascular disease (CVD) risks in this group. OBJECTIVE: To assess the baseline prevalence and predictors of CVD risks among severely obese adolescents undergoing weight-loss surgery. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted from February 28, 2007, to December 30, 2011, at the following 5 adolescent weight-loss surgery centers in the United States: Nationwide Children's Hospital in Columbus, Ohio; Cincinnati Children's Hospital Medical Center in Cincinnati, Ohio; Texas Children's Hospital in Houston; University of Pittsburgh Medical Center in Pittsburgh, Pennsylvania; and Children's Hospital of Alabama in Birmingham...
May 2015: JAMA Pediatrics
https://www.readbyqxmd.com/read/25683069/25th-anniversary-state-of-the-art-expert-discussion-with-carroll-mcwilliams-harmon-md-phd-on-single-site-surgical-techniques-past-present-and-future
#20
Carroll McWilliams Harmon, Daniel J Ostlie
No abstract text is available yet for this article.
February 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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