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JOURNAL ARTICLE
Denise F Lillvis, Karen M Sheehan, Jihnhee Yu, Katia Noyes, Carroll Harmon, Dennis Z Kuo
BACKGROUND AND OBJECTIVES: Children and Youth with Special Health Care Needs (CYSHCN) have differing risk factors and injury characteristics compared with peers without special health care needs (SHCN). We examined the association between SHCN status and complications, mortality, and length of stay (LOS) after trauma hospitalization. METHODS: We conducted a cross-sectional study using 2018 data from the National Trauma Data Bank for patients aged 1 to 18 years (n = 108 062)...
August 16, 2023: Hospital Pediatrics
#2
REVIEW
Sreekanth Vemulapalli, Matheus Simonato, Ori Ben Yehuda, Changfu Wu, Ted Feldman, Jeffrey J Popma, Kartik Sundareswaren, Carole Krohn, Karen M Hardy, Kimberly Guibone, Barbara Christensen, Maria C Alu, Vivian G Ng, Katherine H Chau, Shmuel Chen, Bahira Shahim, Flavien Vincent, John MacMahon, Stefan James, Michael Mack, Martin B Leon, Vinod H Thourani, John Carroll, Mitchell W Krucoff
Mitral regurgitation is the most common valvular disease and is estimated to affect over 5 million Americans. Real-world data collection contributes to safety and effectiveness evidence for the U.S. Food and Drug Administration, quality evaluation for the Centers for Medicare and Medicaid Services and hospitals, and clinical best practice research. We aimed to establish a minimum core data set in mitral interventions to promote efficient, reusable real-world data collection for all of these purposes. Two expert task forces separately evaluated and reconciled a list of candidate elements derived from: 1) 2 ongoing transcatheter mitral trials; and 2) a systemic literature review of high-impact mitral trials and U...
June 26, 2023: JACC. Cardiovascular Interventions
#3
JOURNAL ARTICLE
Palak Patel, Stephanie Harmon, Rachael Iseman, Olga Ludkowski, Heidi Auman, Sarah Hawley, Lisa F Newcomb, Daniel W Lin, Peter S Nelson, Ziding Feng, Hilary D Boyer, Maria S Tretiakova, Larry D True, Funda Vakar-Lopez, Peter R Carroll, Matthew R Cooperberg, Emily Chan, Jeff Simko, Ladan Fazli, Martin Gleave, Antonio Hurtado-Coll, Ian M Thompson, Dean Troyer, Jesse K McKenney, Wei Wei, Peter L Choyke, Gennady Bratslavsky, Baris Turkbey, D Robert Siemens, Jeremy Squire, Yingwei P Peng, James D Brooks, Tamara Jamaspishvili
Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and can be measured via immunohistochemistry. The purpose of the study was to establish the clinical application of an in-house developed artificial intelligence (AI) image analysis workflow for automated detection of PTEN loss on digital images for identifying patients at risk of early recurrence and metastasis. Postsurgical tissue microarray sections from the Canary Foundation (n = 1264) stained with anti-PTEN antibody were evaluated independently by pathologist conventional visual scoring (cPTEN) and an automated AI-based image analysis pipeline (AI-PTEN)...
October 2023: Modern Pathology
#4
JOURNAL ARTICLE
Indrajit Majumdar, Andrew H Talal, Carrol M Harmon, Emily Tabaczynsk, Kristen Cercone, Brian H Wrotniak, Lucy D Mastrandrea, Teresa Quattrin
The pilot study evaluated contingency management (CM) for family-based obesity therapy (FBT). The secondary outcome assessed the association of the hepatic transient electrography (TE) parameters, including the controlled attenuation parameter (CAP) and liver stiffness (LSM), and changes in liver function blood tests and BMI changes in youth involved in intensive FBT. It included youth-parent dyads from an urban pediatric center randomized to weekly behavioral therapy (BT, n= 4) who received fixed financial compensation for attendance, or BT+CM (n= 5) who received an escalating monetary reward for weight loss...
March 2023: Curēus
#5
JOURNAL ARTICLE
Ruth A Lewit, Carroll M Harmon, Robert Ricca, Barrie S Rich, Mehul V Raval, Ying Z Weatherall
BACKGROUND: Metabolic and bariatric surgery (MBS) in adolescents has been shown to be safe and effective, but current practice patterns are variable and poorly understood. The aim of this study is to assess current MBS practice patterns among pediatric surgeons in the United States. METHODS: American Pediatric Surgical Association members were surveyed on current bariatric surgery practices. RESULTS: Four hundred and three (40%) surgeons out of a total of 1013 pediatric surgeons responded to the survey...
July 15, 2022: Journal of Pediatric Surgery
#6
JOURNAL ARTICLE
GA4GH: International policies and standards for data sharing across genomic research and healthcare.
Heidi L Rehm, Angela J H Page, Lindsay Smith, Jeremy B Adams, Gil Alterovitz, Lawrence J Babb, Maxmillian P Barkley, Michael Baudis, Michael J S Beauvais, Tim Beck, Jacques S Beckmann, Sergi Beltran, David Bernick, Alexander Bernier, James K Bonfield, Tiffany F Boughtwood, Guillaume Bourque, Sarion R Bowers, Anthony J Brookes, Michael Brudno, Matthew H Brush, David Bujold, Tony Burdett, Orion J Buske, Moran N Cabili, Daniel L Cameron, Robert J Carroll, Esmeralda Casas-Silva, Debyani Chakravarty, Bimal P Chaudhari, Shu Hui Chen, J Michael Cherry, Justina Chung, Melissa Cline, Hayley L Clissold, Robert M Cook-Deegan, Mélanie Courtot, Fiona Cunningham, Miro Cupak, Robert M Davies, Danielle Denisko, Megan J Doerr, Lena I Dolman, Edward S Dove, L Jonathan Dursi, Stephanie O M Dyke, James A Eddy, Karen Eilbeck, Kyle P Ellrott, Susan Fairley, Khalid A Fakhro, Helen V Firth, Michael S Fitzsimons, Marc Fiume, Paul Flicek, Ian M Fore, Mallory A Freeberg, Robert R Freimuth, Lauren A Fromont, Jonathan Fuerth, Clara L Gaff, Weiniu Gan, Elena M Ghanaim, David Glazer, Robert C Green, Malachi Griffith, Obi L Griffith, Robert L Grossman, Tudor Groza, Jaime M Guidry Auvil, Roderic Guigó, Dipayan Gupta, Melissa A Haendel, Ada Hamosh, David P Hansen, Reece K Hart, Dean Mitchell Hartley, David Haussler, Rachele M Hendricks-Sturrup, Calvin W L Ho, Ashley E Hobb, Michael M Hoffman, Oliver M Hofmann, Petr Holub, Jacob Shujui Hsu, Jean-Pierre Hubaux, Sarah E Hunt, Ammar Husami, Julius O Jacobsen, Saumya S Jamuar, Elizabeth L Janes, Francis Jeanson, Aina Jené, Amber L Johns, Yann Joly, Steven J M Jones, Alexander Kanitz, Kazuto Kato, Thomas M Keane, Kristina Kekesi-Lafrance, Jerome Kelleher, Giselle Kerry, Seik-Soon Khor, Bartha M Knoppers, Melissa A Konopko, Kenjiro Kosaki, Martin Kuba, Jonathan Lawson, Rasko Leinonen, Stephanie Li, Michael F Lin, Mikael Linden, Xianglin Liu, Isuru Udara Liyanage, Javier Lopez, Anneke M Lucassen, Michael Lukowski, Alice L Mann, John Marshall, Michele Mattioni, Alejandro Metke-Jimenez, Anna Middleton, Richard J Milne, Fruzsina Molnár-Gábor, Nicola Mulder, Monica C Munoz-Torres, Rishi Nag, Hidewaki Nakagawa, Jamal Nasir, Arcadi Navarro, Tristan H Nelson, Ania Niewielska, Amy Nisselle, Jeffrey Niu, Tommi H Nyrönen, Brian D O'Connor, Sabine Oesterle, Soichi Ogishima, Vivian Ota Wang, Laura A D Paglione, Emilio Palumbo, Helen E Parkinson, Anthony A Philippakis, Angel D Pizarro, Andreas Prlic, Jordi Rambla, Augusto Rendon, Renee A Rider, Peter N Robinson, Kurt W Rodarmer, Laura Lyman Rodriguez, Alan F Rubin, Manuel Rueda, Gregory A Rushton, Rosalyn S Ryan, Gary I Saunders, Helen Schuilenburg, Torsten Schwede, Serena Scollen, Alexander Senf, Nathan C Sheffield, Neerjah Skantharajah, Albert V Smith, Heidi J Sofia, Dylan Spalding, Amanda B Spurdle, Zornitza Stark, Lincoln D Stein, Makoto Suematsu, Patrick Tan, Jonathan A Tedds, Alastair A Thomson, Adrian Thorogood, Timothy L Tickle, Katsushi Tokunaga, Juha Törnroos, David Torrents, Sean Upchurch, Alfonso Valencia, Roman Valls Guimera, Jessica Vamathevan, Susheel Varma, Danya F Vears, Coby Viner, Craig Voisin, Alex H Wagner, Susan E Wallace, Brian P Walsh, Marc S Williams, Eva C Winkler, Barbara J Wold, Grant M Wood, J Patrick Woolley, Chisato Yamasaki, Andrew D Yates, Christina K Yung, Lyndon J Zass, Ksenia Zaytseva, Junjun Zhang, Peter Goodhand, Kathryn North, Ewan Birney
The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution...
November 10, 2021: Cell Genom
#7
JOURNAL ARTICLE
Sandeep Dhindsa, Husam Ghanim, Todd Jenkins, Thomas H Inge, Carroll M Harmon, Amit Ghoshal, Zengru Wu, Michael J McPhaul, Farid Saad, Paresh Dandona
OBJECTIVE: Obesity in adolescent males is associated with the lowering of total and free testosterone concentrations. Weight loss may increase testosterone concentrations. DESIGN AND METHODS: We evaluated the changes in sex hormones following bariatric surgery in 34 males (age range: 14.6-19.8 years) with obesity. These participants were part of a prospective multicenter study, Teen-Longitudinal Assessment of Bariatric Surgery. The participants were followed up for 5 years after surgery...
February 1, 2022: European Journal of Endocrinology
#8
JOURNAL ARTICLE
Brent J Small, Marie Lange, Wanting Zhai, Jaeil Ahn, Tim A Ahles, Judith E Carroll, Harvey J Cohen, Deena Graham, Martine Extermann, Natacha Heutte, Heather S L Jim, Brenna C McDonald, Sunita K Patel, James C Root, Andrew J Saykin, Kathleen Van Dyk, Xingtao Zhou, Jeanne Mandelblatt, Florence Joly
PURPOSE: Older cancer patients are susceptible to long-term effects of chemotherapy, including cancer-related cognitive decline and impairments to quality of life. Taxane-based chemotherapies are associated with physical declines among older women and may negatively impact cognitive performance. We sought to examine whether changes in objective and subjective measures of cognitive performance and well-being differ among older breast cancer survivors as a function of taxane-based chemotherapy treatment regimens...
November 24, 2021: Breast Cancer Research and Treatment
#9
RANDOMIZED CONTROLLED TRIAL
Martin L Blakely, Jon E Tyson, Kevin P Lally, Susan R Hintz, Barry Eggleston, David K Stevenson, Gail E Besner, Abhik Das, Robin K Ohls, William E Truog, Leif D Nelin, Brenda B Poindexter, Claudia Pedroza, Michele C Walsh, Barbara J Stoll, Rachel Geller, Kathleen A Kennedy, Reed A Dimmitt, Waldemar A Carlo, C Michael Cotten, Abbot R Laptook, Krisa P Van Meurs, Kara L Calkins, Gregory M Sokol, Pablo J Sanchez, Myra H Wyckoff, Ravi M Patel, Ivan D Frantz, Seetha Shankaran, Carl T D'Angio, Bradley A Yoder, Edward F Bell, Kristi L Watterberg, Colin A Martin, Carroll M Harmon, Henry Rice, Arlet G Kurkchubasche, Karl Sylvester, James C Y Dunn, Troy A Markel, Diana L Diesen, Amina M Bhatia, Alan Flake, Walter J Chwals, Rebeccah Brown, Kathryn D Bass, Shawn D St Peter, Christina M Shanti, Walter Pegoli, David Skarda, Joel Shilyansky, David G Lemon, Ricardo A Mosquera, Myriam Peralta-Carcelen, Ricki F Goldstein, Betty R Vohr, Isabell B Purdy, Abbey C Hines, Nathalie L Maitre, Roy J Heyne, Sara B DeMauro, Elisabeth C McGowan, Kimberly Yolton, Howard W Kilbride, Girija Natarajan, Kelley Yost, Sarah Winter, Tarah T Colaizy, Matthew M Laughon, Satyanarayana Lakshminrusimha, Rosemary D Higgins
OBJECTIVE: The aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP). SUMMARY BACKGROUND DATA: The impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown. METHODS: We conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage...
October 1, 2021: Annals of Surgery
#10
J Adams, C Adler, M M Aggarwal, Z Ahammed, J Amonett, B D Anderson, M Anderson, D Arkhipkin, G S Averichev, S K Badyal, J Balewski, O Barannikova, L S Barnby, J Baudot, S Bekele, V V Belaga, R Bellwied, J Berger, B I Bezverkhny, S Bhardwaj, P Bhaskar, A K Bhati, H Bichsel, A Billmeier, L C Bland, C O Blyth, B E Bonner, M Botje, A Boucham, A Brandin, A Bravar, R V Cadman, X Z Cai, H Caines, M Calderón de la Barca Sánchez, J Carroll, J Castillo, M Castro, D Cebra, P Chaloupka, S Chattopadhyay, H F Chen, Y Chen, S P Chernenko, M Cherney, A Chikanian, B Choi, W Christie, J P Coffin, T M Cormier, J G Cramer, H J Crawford, M Csanád, D Das, S Das, A A Derevschikov, L Didenko, T Dietel, W J Dong, X Dong, J E Draper, F Du, A K Dubey, V B Dunin, J C Dunlop, M R Dutta Majumdar, V Eckardt, L G Efimov, V Emelianov, J Engelage, G Eppley, B Erazmus, M Estienne, P Fachini, V Faine, J Faivre, R Fatemi, K Filimonov, P Filip, E Finch, Y Fisyak, D Flierl, K J Foley, J Fu, C A Gagliardi, N Gagunashvili, J Gans, M S Ganti, L Gaudichet, M Germain, F Geurts, V Ghazikhanian, P Ghosh, J E Gonzalez, O Grachov, V Grigoriev, S Gronstal, D Grosnick, M Guedon, S M Guertin, A Gupta, E Gushin, T D Gutierrez, T J Hallman, D Hardtke, J W Harris, M Heinz, T W Henry, S Heppelmann, T Herston, B Hippolyte, A Hirsch, E Hjort, G W Hoffmann, M Horsley, H Z Huang, S L Huang, T J Humanic, G Igo, A Ishihara, P Jacobs, W W Jacobs, M Janik, H Jiang, I Johnson, P G Jones, E G Judd, S Kabana, M Kaneta, M Kaplan, D Keane, V Yu Khodyrev, J Kiryluk, A Kisiel, J Klay, S R Klein, A Klyachko, D D Koetke, T Kollegger, M Kopytine, L Kotchenda, A D Kovalenko, M Kramer, P Kravtsov, V I Kravtsov, K Krueger, C Kuhn, A I Kulikov, A Kumar, G J Kunde, C L Kunz, R Kh Kutuev, A A Kuznetsov, M A C Lamont, J M Landgraf, S Lange, C P Lansdell, B Lasiuk, F Laue, J Lauret, A Lebedev, R Lednický, M J LeVine, C Li, Q Li, S J Lindenbaum, M A Lisa, F Liu, L Liu, Z Liu, Q J Liu, T Ljubicic, W J Llope, H Long, R S Longacre, M Lopez-Noriega, W A Love, T Ludlam, D Lynn, J Ma, R Ma, Y G Ma, D Magestro, S Mahajan, L K Mangotra, D P Mahapatra, R Majka, R Manweiler, S Margetis, C Markert, L Martin, J Marx, H S Matis, Yu A Matulenko, T S McShane, F Meissner, Yu Melnick, A Meschanin, M Messer, M L Miller, Z Milosevich, N G Minaev, C Mironov, D Mishra, J Mitchell, B Mohanty, L Molnar, C F Moore, M J Mora-Corral, D A Morozov, V Morozov, M M de Moura, M G Munhoz, B K Nandi, S K Nayak, T K Nayak, J M Nelson, P Nevski, T Niida, V A Nikitin, L V Nogach, B Norman, S B Nurushev, G Odyniec, A Ogawa, V Okorokov, M Oldenburg, D Olson, G Paic, S U Pandey, S K Pal, Y Panebratsev, S Y Panitkin, A I Pavlinov, T Pawlak, V Perevoztchikov, C Perkins, W Peryt, V A Petrov, S C Phatak, R Picha, M Planinic, J Pluta, N Porile, J Porter, A M Poskanzer, M Potekhin, E Potrebenikova, B V K S Potukuchi, D Prindle, C Pruneau, J Putschke, G Rai, G Rakness, R Raniwala, S Raniwala, O Ravel, R L Ray, S V Razin, D Reichhold, J G Reid, G Renault, F Retiere, A Ridiger, H G Ritter, J B Roberts, O V Rogachevski, J L Romero, A Rose, C Roy, L J Ruan, R Sahoo, I Sakrejda, S Salur, J Sandweiss, I Savin, J Schambach, R P Scharenberg, N Schmitz, L S Schroeder, K Schweda, J Seger, D Seliverstov, P Seyboth, E Shahaliev, M Shao, M Sharma, K E Shestermanov, S S Shimanskii, R N Singaraju, F Simon, G Skoro, N Smirnov, R Snellings, G Sood, P Sorensen, J Sowinski, H M Spinka, B Srivastava, S Stanislaus, R Stock, A Stolpovsky, M Strikhanov, B Stringfellow, C Struck, A A P Suaide, E Sugarbaker, C Suire, M Šumbera, B Surrow, T J M Symons, A Szanto de Toledo, P Szarwas, A Tai, J Takahashi, A H Tang, D Thein, J H Thomas, V Tikhomirov, T Todoroki, M Tokarev, M B Tonjes, T A Trainor, S Trentalange, R E Tribble, M D Trivedi, V Trofimov, O Tsai, T Ullrich, D G Underwood, G Van Buren, A M VanderMolen, A N Vasiliev, M Vasiliev, S E Vigdor, Y P Viyogi, S A Voloshin, W Waggoner, F Wang, G Wang, X L Wang, Z M Wang, H Ward, J W Watson, R Wells, G D Westfall, C Whitten, H Wieman, R Willson, S W Wissink, R Witt, J Wood, J Wu, N Xu, Z Xu, Z Z Xu, E Yamamoto, P Yepes, V I Yurevich, Y V Zanevski, I Zborovský, H Zhang, W M Zhang, Z P Zhang, P A Żołnierczuk, R Zoulkarneev, J Zoulkarneeva, A N Zubarev
This corrects the article DOI: 10.1103/PhysRevLett.92.062301.
August 6, 2021: Physical Review Letters
#11
Igor Sukhotnik, A Semih Gork, Min Chen, Robert A Drongowski, Arnold G Coran, Carroll M Harmon
No abstract text is available yet for this article.
July 2021: Pediatric Surgery International
#12
JOURNAL ARTICLE
Ashley V Austin, David S Owens, Jordan M Prutkin, Jack C Salerno, Brian Ko, Hank F Pelto, Ashwin L Rao, David M Siebert, Jennifer S Carrol, Kimberly G Harmon, Jonathan A Drezner
OBJECTIVES: We assessed whether the presence and character of a cardiac murmur in adolescents were associated with structural heart disease that confers risk of sudden cardiac death (SCD). METHODS: We performed a retrospective analysis of 15 141 adolescents age 12-19 who underwent a heart screen with history, physical examination and ECG. Participants with any screening abnormality underwent an echocardiogram for the assessment of structural heart disease. Murmurs were classified as physiological or pathological according to standard clinical criteria, and participants with murmurs were compared with a comparison group without murmurs...
January 2022: British Journal of Sports Medicine
#13
JOURNAL ARTICLE
Kristen A Calabro, Carroll M Harmon, Kaveh Vali
Background: Common bile duct (CBD) injury is one of the most serious complications of laparoscopic cholecystectomy and carries an incidence of 0.3%-0.7%. Recently indocyanine green (ICG) fluorescent cholangiography (FC) has been used as an adjunct to identify the biliary tract during adult laparoscopic cholecystectomy, allowing intraoperative identification of biliary anatomy. The objective of this article is to show its successful use in pediatric laparoscopic cholecystectomies. Method: From July 1, 2017, to November 30, 2018, surgeons at John R...
May 2020: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
#14
JOURNAL ARTICLE
Abdulrouf Lamoshi, Artur Chernoguz, Carroll M Harmon, Michael Helmrath
Over the past decade, outcomes data have demonstrated the benefit of bariatric surgery in achieving both sustained weight loss and reversal of co-morbidities. Comparing these data to contemporary known risks of adolescent bariatric surgery informs the patients and providers considering bariatric procedures and provides insight into potential ways to reduce and manage complications. The goal of this article is to review the common surgical and postoperative complications following bariatric procedures and discuss approaches to improve their safety...
February 2020: Seminars in Pediatric Surgery
#15
JOURNAL ARTICLE
Lindel C Dewberry, Anahita Jalivand, Resmi Gupta, Todd M Jenkins, Andrew Beamish, Thomas H Inge, Anita Courcoulas, Michael Helmrath, Mary L Brandt, Carroll M Harmon, Mike Chen, John B Dixon, Margaret Zeller, Marc P Michalsky
OBJECTIVE: This prospective cohort analysis describes changes in weight, cardiometabolic health, and weight-related quality of life (WRQOL) following adolescent LAGB. METHODS: Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) collected demographic, anthropometric, micronutrient, cardiometabolic risk, and WRQOL data for 242 adolescents. Data through 5 years were analyzed for 14 participants who underwent LAGB with 2 patients lost to follow-up. RESULTS: Participants (mean age 18...
March 2, 2020: Obesity Surgery
#16
JOURNAL ARTICLE
Radu Filipescu, Colin Powers, Han Yu, Jihnhee Yu, David H Rothstein, Carroll M Harmon, Brian Clemency, Weidun A Guo, Kathryn D Bass
BACKGROUND: The Revised Trauma Score is the standard physiologic injury severity indicator used in trauma research and quality control. Shock index, peripheral oxygen saturation, and temperature have emerged as strong predictors for mortality and morbidity. We hypothesized that replacing systolic blood pressure and respiratory rate with age-adjusted shock index and peripheral oxygen saturation and adding temperature would generate a more accurate model, valid across all ages. METHODS: This is a retrospective database analysis using children and adults from the National Trauma Data Bank for years 2011 to 2015...
May 2020: Surgery
#17
JOURNAL ARTICLE
Radu Filipescu, Colin Powers, Han Yu, David H Rothstein, Carroll M Harmon, Brian Clemency, Weidun A Guo, Kathryn D Bass
BACKGROUND: Nonoperative management (NOM) is commonly utilized in hemodynamically stable children with blunt splenic injuries (BSI). Guidelines published by the American Pediatric Surgical Association over the past 15 years support this approach. We sought to determine the rates and outcomes of NOM in pediatric BSI and compare trends between pediatric (PTC), mixed (MTC) and adult trauma centers (ATC). METHODS: This was a retrospective database analysis of the NTDB data from 2011 to 2015 including pediatric patients with BSI, as described by ICD-9-CM Codes 865...
September 2020: Journal of Pediatric Surgery
#18
REVIEW
Yingkui Yang, Carroll M Harmon
The adrenocorticotropic hormone (ACTH) receptor, known as the melanocortin-2 receptor (MC2R), plays a key role in regulating adrenocortical function. ACTH receptor is a subtype of the melanocortin receptor family which is a member of the G-protein coupled receptor (GPCR) superfamily. ACTH receptor has unique characteristics among MCRs. α-MSH, β-MSH, γ-MSH and ACTH are agonists for MCRs but only ACTH is the agonist for ACTH receptor. In addition, the melanocortin receptor accessory protein (MRAP) is required for ACTH receptor expression at cell surface and function...
March 1, 2020: Molecular and Cellular Endocrinology
#19
MULTICENTER STUDY
Sharon Bout-Tabaku, Resmi Gupta, Todd M Jenkins, Justin R Ryder, Amy E Baughcum, Rebecca D Jackson, Thomas H Inge, John B Dixon, Michael A Helmrath, Anita P Courcoulas, James E Mitchell, Carroll M Harmon, Changchun Xie, Marc P Michalsky
OBJECTIVES: To evaluate the longitudinal effects of metabolic and bariatric surgery (MBS) on the prevalence of musculoskeletal and lower extremity (LE) pain, physical function, and health-related quality of life. METHODS: The Teen Longitudinal Assessment of Bariatric Surgery study (NCT00474318) prospectively collected data on 242 adolescents undergoing MBS at 5 centers over a 3-year follow-up. Joint pain and physical function outcomes were assessed by using the Health Assessment Questionnaire Disability Index, Impact of Weight on Quality of Life - Kids, and the Short Form 36 Health Survey...
December 2019: Pediatrics
#20
JOURNAL ARTICLE
Stavra A Xanthakos, Jane C Khoury, Thomas H Inge, Todd M Jenkins, Avani C Modi, Marc P Michalsky, Mike K Chen, Anita P Courcoulas, Carroll M Harmon, Mary L Brandt, Michael A Helmrath, Heidi J Kalkwarf
BACKGROUND & AIMS: Little is known about prevalence and risk factors for nutritional deficiencies in adolescents after metabolic bariatric surgery. We performed a 5-year prospective cohort study of these. METHODS: Adolescents who had Roux-en-Y gastric bypass (RYGB, n = 161) or vertical sleeve gastrectomy (VSG, n = 67) were enrolled at 5 tertiary-care centers from March 2007 through February 2012. The final analysis cohort included 226 participants (161 who had RYGB and 65 who had VSG)...
May 2020: Clinical Gastroenterology and Hepatology
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