Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Xu Yang, Junqi Zhang, Yanghao Li, Huiting Hu, Xiang Li, Tonghui Ma, Bo Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: The efficacy of clinical treatments for various liver diseases is intricately tied to the liver's regenerative capacity. Insufficient or failed liver regeneration is a direct cause of mortality following fulminant hepatic failure and extensive hepatectomy. Si-Ni-San (SNS), a renowned traditional Chinese medicine prescription for harmonizing liver and spleen functions, has shown clinical efficacy in the alleviation of liver injury for thousands of years...
February 19, 2024: Journal of Ethnopharmacology
#22
JOURNAL ARTICLE
Elizabeth S Greene, Travis W Tabler, Sara K Orlowski, Sami Dridi
Genetic selection for high growth rate has resulted in spectacular progress in feed efficiency in chickens. As feed intake and water consumption (WC) are associated and both are affected by environmental conditions, we evaluated WC and its hypothalamic regulation in three broiler-based research lines and their ancestor jungle fowl (JF) under heat stress (HS) conditions. Slow growing ACRB, moderate growing 95RB, fast growing MRB, and JF were exposed to daily chronic cyclic HS (36 °C, 9 h/d) or thermoneutral temperature (24 °C)...
February 14, 2024: Brain Research
#23
JOURNAL ARTICLE
Lauren Stover, Hanieh Bahramimoghaddam, Lie Wang, Samantha Schrecke, Gaya P Yadav, Ming Zhou, Arthur Laganowsky
Aquaporin Z (AqpZ), a bacterial water channel, forms a tetrameric complex and, like many other membrane proteins, activity is regulated by lipids. Various methods have been developed to facilitate structure determination of membrane proteins, such as the use of antibodies. Here, we graft onto AqpZ the ALFA tag (AqpZ-ALFA), an alpha helical epitope, to make use of the high-affinity anti-ALFA nanobody (nB). Native mass spectrometry reveals the AqpZ-ALFA fusion forms a stable, 1:1 complex with nB. Single-particle cryogenic electron microscopy studies reveal the octameric (AqpZ-ALFA)4 (nB)4 complex forms a dimeric assembly and the structure was determined to 1...
June 2024: Journal of structural biology: X
#24
JOURNAL ARTICLE
Hanyu Shaw, Chaoyi Feng, Meng Qi, Yalan Deng, Wei Chen, Yiyin Zhang, Luxi Wang, Naier Lin, Guohong Tian, Yan Sha
PURPOSE: Despite mounting evidence indicating that aquaporin-4 antibody-positive optic neuritis (AQP4-ON) presents a less favorable prognosis than other types of optic neuritis, there exists substantial heterogeneity in the prognostic outcomes within the AQP4-ON cohort. Considering the persistent debate over the role of MRI in assessing the prognosis of optic neuritis, we aim to investigate the correlation between the MRI appearance and long-term visual prognosis in AQP4-ON patients. METHODS: We retrospectively reviewed the ophthalmological and imaging data of AQP4-ON patients admitted to our Neuro-ophthalmology Department from January 2015 to March 2018, with consecutive follow-up visits for a minimum of 3 years...
February 15, 2024: Neuroradiology
#25
JOURNAL ARTICLE
Mohamad Ghazanfari Hashemi, Vahid Talebi, Naghmeh Abbasi Kasbi, Mehrshad Abbasi, Nasrin Asgari, Mohammad Ali Sahraian
BACKGROUND: T1 hypointense lesions are considered a surrogate marker of tissue destruction. Although there is a shortage of evidence about T1 hypointense brain lesions, black holes, in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD), the clinical significance of these lesions is not well determined. OBJECTIVES: The impact of T1 hypointense brain lesions on the clinical status and the disability level of patients with NMOSD was sought in this study. METHODS: A total of 83 patients with the final diagnosis of NMOSD were recruited...
February 12, 2024: BMC Neurology
#26
JOURNAL ARTICLE
Patrycja Oberska, Marta Grabowska, Marta Marynowska, Maciej Murawski, Dariusz Gączarzewicz, Andrzej Syczewski, Katarzyna Michałek
The increasing incidence of male infertility in humans and animals creates the need to search for new factors that significantly affect the course of reproductive processes. Therefore, the aim of this study was to determine the temporospatial expression of aquaglyceroporins (AQP3, AQP7 and AQP9) in the bovine ( Bos taurus ) reproductive system using immunohistochemistry and Western blotting. The study also included morphological analysis and identification of GATA-4. In brief, in immature individuals, AQP3 and AQP7 were found in gonocytes...
January 26, 2024: International Journal of Molecular Sciences
#27
REVIEW
Arkadyuti Bhattacharjee, Ankit Jana, Swagato Bhattacharjee, Sankalan Mitra, Swagata De, Badrah S Alghamdi, Mohammad Zubair Alam, Ahmad Bakur Mahmoud, Zainab Al Shareef, Wael M Abdel-Rahman, Chan Woon-Khiong, Athanasios Alexiou, Marios Papadakis, Ghulam Md Ashraf
Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes...
February 9, 2024: Cell Communication and Signaling: CCS
#28
JOURNAL ARTICLE
Fábio Colonheze, Marilia Martins Cavariani, Bruno Cesar Schimming, Talita de Mello Santos, Luiz Gustavo de Almeida Chuffa, Raquel Fantin Domeniconi
Maternal protein restriction delays the differentiation of epididymal mesenchymal cells in newborn rats. However, it's unclear if this delay persists until the full differentiation of the epididymal epithelium at 44 days postnatal. Thus, this study aimed to assess the impact of maternal protein reduction on 44-day-old rats' epididymal epithelium differentiation, following up on the observed delay in newborn animals. Pregnant rats were randomly divided into groups receiving normal-protein (NP - 17% protein) or low-protein (LP - 6% protein) diets during gestation and lactation...
February 7, 2024: Biology Open
#29
JOURNAL ARTICLE
Eric Judd, Vineeta Kumar, Paige M Porrett, Kelly A Hyndman, Douglas Anderson, Maggie Jones-Carr, Andrew Shunk, Daniel R Epstein, Huma Fatima, Akemi Katsurada, Ryousuke Satou, L Gabriel Navar, Jayme E Locke
Demand for kidney grafts outpaces supply, limiting kidney transplantation as a treatment for kidney failure. Xenotransplantation has the potential to make kidney transplantation available to many more patients with kidney failure, but the ability of xenografts to support human physiologic homeostasis has not been established. A brain-dead adult decedent underwent bilateral native nephrectomies followed by 10 gene-edited (four gene knockouts, six human transgenes) pig-to-human xenotransplantation. Physiologic parameters and laboratory values were measured for seven days in a critical care setting...
January 28, 2024: Kidney International
#30
JOURNAL ARTICLE
Anuradha Kalita, Manas Das
Aquaporins like AQP1, AQP3, and AQP4 are known to be involved in the pathophysiology of inflammation based on earlier reports. This study aimed to evaluate the involvement of Aquaporins as a potential target of inflammation. The study also investigates the efficacy of methanolic extract of Garcinia (GME) and its potent phytocompound (garcinol) against the Aquaporins involved in inflammation. siRNA silencing of AQP3 was carried out in RAW264.7 cells followed by LPS stimulation (1 µg/ml) and assessment of important markers of inflammation including NO, PGE2, TNF-α, IL-6, IL-1β, CCL20, iNOS and COX-2...
January 24, 2024: Inflammopharmacology
#31
JOURNAL ARTICLE
Olof Carlsson, Dagur Ingi Jonsson, Lou Brundin, Ellen Iacobaeus
Neuromyelitis optica spectrum disorder (NMOSD) is a rare immune-mediated relapsing-remitting disease of the central nervous system. The usage of rituximab, as relapse-preventive therapy, in NMOSD is common. We performed a single-center retrospective cohort study to assess the risk of relapses and severe infectious events (SIEs) in rituximab-treated NMOSD patients. This study included 24 aquaporin-4 IgG+ (AQP4+), 8 myelin-oligodendrocyte-protein IgG+ (MOG+), and 10 double-seronegative NMOSD patients. Relapses were observed in 50% of all patients during a mean treatment time of 4...
January 8, 2024: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Michael Thormann, Nadine Traube, Nasser Yehia, Roland Koestler, Gergana Galabova, Nanna MacAulay, Trine L Toft-Bertelsen
Cerebral edema is a life-threatening condition that can cause permanent brain damage or death if left untreated. Existing therapies aim at mitigating the associated elevated intracranial pressure, yet they primarily alleviate pressure rather than prevent edema formation. Prophylactic anti-edema therapy necessitates novel drugs targeting edema formation. Aquaporin 4 (AQP4), an abundantly expressed water pore in mammalian glia and ependymal cells, has been proposed to be involved in cerebral edema formation. A series of novel compounds have been tested for their potential inhibitory effects on AQP4...
January 11, 2024: International Journal of Molecular Sciences
#33
JOURNAL ARTICLE
Zhao-Zhe Xin, Zhi-Qiang Zhu, Jiu-Yang Chen, Ya-Li Xu, Xin-Tong Zhang, Jin-Yong Zhang
Ameson portunus, recently discovered the causative agent of "toothpaste disease" of pond-cultured swimming crabs in China has caused enormous economic losses in aquaculture. Understanding the process of spore germination is helpful to elucidate the molecular mechanism of its invasion of host cells. Here, we obtained mature and germinating spores by isolation and purification and in vitro stimulation, respectively. Then, non-germinated and germinated spores were subjected to the comparative transcriptomic analysis to disclose differential molecular responses of these two stages...
January 19, 2024: Journal of Invertebrate Pathology
#34
REVIEW
Fatemeh Abdi, Sadaf Parvin, Vahid Zare Hosseinabadi, Maryam Kachuei, Arzhang Gordiz, Sara Hemmati, Parvaneh Karimzadeh
INTRODUCTION: Biotinidase deficiency (BD) is an inherited autosomal recessive metabolic disorder. BD has been associated with optic nerve atrophy, eye infections, and retinopathy. The most prevalent ophthalmic manifestation of BD is optic atrophy, which might be misdiagnosed as multiple sclerosis or neuromyelitis optica, especially in late-onset BD cases. METHODS: In this article, we report a 9-year-old boy with gradual vision loss. Ophthalmologic examination, Brain MRI, and several laboratory tests such as Aquaporin-4 IgG level and biotinidase level were done on the patient...
January 17, 2024: Ophthalmic Genetics
#35
JOURNAL ARTICLE
Tatchaporn Ongphichetmetha, Saharat Aungsumart, Sasitorn Siritho, Metha Apiwattanakul, Jantima Tanboon, Natthapon Rattanathamsakul, Naraporn Prayoonwiwat, Jiraporn Jitprapaikulsan
Tumefactive demyelinating lesions (TDL), characterized by large (≥ 2 cm) demyelinating lesions mimicking tumors, are a rare manifestation of the central nervous system inflammatory demyelinating diseases (CNS-IDD). Distinguishing TDL from other brain lesions can be challenging, often necessitating biopsy or advanced diagnostics. The natural history of TDL varies among races. This study aimed to assess demographics, clinical and radiological features, laboratory findings, management, and outcomes of Thai patients with TDL...
January 16, 2024: Scientific Reports
#36
JOURNAL ARTICLE
Yumei Yue, Xiaodan Zhang, Wen Lv, Hsin-Yi Lai, Ting Shen
Parkinson's disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins, including α-synuclein, amyloid-β, and tau, in addition to the impaired elimination of these neurotoxic protein. Atypical parkinsonism, which has the same clinical presentation and neuropathology as Parkinson's disease, expands the disease landscape within the continuum of Parkinson's disease and related disorders. The glymphatic system is a waste clearance system in the brain, which is responsible for eliminating the neurotoxic proteins from the interstitial fluid...
September 1, 2024: Neural Regeneration Research
#37
JOURNAL ARTICLE
Xi Chen, Jie Zhang, Li-Shan Shen, Yao-Ping Chen, Jin-Quan Yang, Wen-Jie Tang, Ruo-Mi Guo
BACKGROUND: Multiple sclerosis (MS) is a condition that can impact the central nervous system (CNS) and cause damage to the myelin, which is responsible for facilitating the normal transmission of electrical impulses along the nerves. We performed a bibliometric analysis of the scientific publications on myelin imaging in MS to reveal the development trends in this field and to evaluate research trends in myelin imaging in MS. METHODS: The Web of Science Core Collection was searched for articles related to myelin imaging in MS published between January 2000 and December 2022...
January 3, 2024: Quantitative Imaging in Medicine and Surgery
#38
JOURNAL ARTICLE
Chenyang Gao, Lei Su, Hongfang Li, Tian Song, Yaou Liu, Yunyun Duan, Fu-Dong Shi
OBJECTIVE: To characterize the susceptibility-weighted image (SWI) features including paramagnetic rim and nodular lesions with signal intensity changes and central vein sign (CVS) associated with aquaporin 4 (AQP4)-immunoglobulin G (IgG)-negative neuromyelitis optica spectrum disorder (NMOSD), and explore whether they can be used as potential imaging biomarkers for differentiating multiple sclerosis (MS) from this disorder. METHODS: We prospectively recruited NMOSD with AQP4-IgG-negative (AQP4- NMOSD) and IgG-positive (AQP4+ NMOSD), and MS subjects from the Clinical and Imaging Patterns of Neuroinflammation Diseases in China (CLUE) project (NCT0410683) between 2019 and 2021...
December 28, 2023: Multiple Sclerosis and related Disorders
#39
JOURNAL ARTICLE
Meltem Çobanoğulları Direk, Şeyda Besen, İbrahim Öncel, Ceren Günbey, Orhan Özdoğan, Leman Tekin Orgun, Sevim Sahin, Ali Cansu, Nihal Yıldız, Seda Kanmaz, Sanem Yılmaz, Hasan Tekgül, Dilşad Türkdoğan, Olcay Ünver, Gülten Öztürk Thomas, Salih Başıbüyük, Deniz Yılmaz, Ayşegül Neşe Kurt, Pembe Gültutan, Özlem Özsoy, Uluç Yiş, Semra Hız Kurul, Serdal Güngör, Bilge Özgör, Meral Karadağ, Nihal Olgaç Dündar, Pınar Gençpınar, Olgay Bildik, Sibğatullah Ali Orak, Çişil Çerçi Kabur, Bülent Kara, Ömer Karaca, Mehmet Canpolat, Hakan Gümüş, Hüseyin Per, Ünsal Yılmaz, Pakize Karaoğlu, Özlem Ersoy, Ayşe Tosun, Semra Büyükkorkmaz Öztürk, Deniz Yüksel, Ergin Atasoy, Kıvılcım Gücüyener, Miraç Yıldırım, Ömer Bektaş, Dilek Çavuşoğlu, Çoşkun Yarar, Olcay Güngör, Gülen Gül Mert, Esra Sarıgeçili, Selvinaz Edizer, İpek Dokurel Çetin, Seren Aydın, Betül Diler, Asena Ayça Özdemir, İlknur Erol, Çetin Okuyaz, Banu Anlar
BACKGROUND: Various etiologies may underlie optic neuritis, including autoantibody-mediated disorders described in the last decade. We re-examined demographic, clinical, laboratory features and prognostic factors in pediatric patients with autoimmune optic neuritis according to current knowledge. METHODS: Cases of pediatric ON from 27 centers in Türkiye diagnosed between 2009 and 2022 were included for retrospective evaluation. RESULTS: The study included 279 patients, 174 females and 105 males, with a female-to-male ratio of 1...
November 26, 2023: Multiple Sclerosis and related Disorders
#40
JOURNAL ARTICLE
Satoshi Hirako, Yoshihiro Wakayama, Hyounju Kim, Yuzuru Iizuka, Nobuhiro Wada, Naoko Kaibara, Mai Okabe, Satoru Arata, Akiyo Matsumoto
Aquaporin (AQP) 7 and AQP9 are membrane channel proteins called aquaglyceroporins and are related to glucose and lipid metabolism. AQP7 is mainly expressed in white adipose tissue (WAT) and is involved in releasing glycerol into the bloodstream. AQP9 is the glycerol channel in the liver that supplies glycerol to the hepatic cells. In this study, we investigated the relationship between the expression of aquaglyceroporins and lifestyle-related diseases, such as obesity and fatty liver, using 22-week-old db/db mice...
December 2023: Zoological Science
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
