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Aquaporin 9

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https://www.readbyqxmd.com/read/27885529/lack-of-aquaporin-9-reduces-brain-angiogenesis-and-exaggerates-neuronal-loss-in-the-hippocampus-following-intracranial-hemorrhage-in-mice
#1
Weiyang Ji, Jing Wang, Jie Xu, Xudong Zhao, Xing Xu, Xiaojie Lu
Intracranial hemorrhage (ICH) is a common subtype of stroke with high morbidity and mortality. However, few clinical therapies that can reduce ICH-induced brain injury and promote the recovery outcome in ICH patients are available to improve the recovery from ICH. Given that aquaporin 9 (AQP9) plays a critical role in brain edema after ischemic stroke and traumatic brain injury and is involved in the regulation of angiogenesis, we examined the role of AQP9 in preventing neuronal loss and in neovascularization in the dorsal hippocampus (DH) after ICH...
November 24, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27817002/overexpression-of-aquaporin-1-is-a-prognostic-factor-for-biochemical-recurrence-in-prostate-adenocarcinoma
#2
Ji Y Park, GhilSuk Yoon
Aquaporins (AQP) are transmembrane proteins that provide channels for water and solutes, and some are involved in tumor progression and invasion. We evaluated the expression of AQP-1, AQP-3, and AQP-5 and their clinicopathological significance in prostate adenocarcinomas (PCA). Prostatectomy specimens (n = 99) were retrieved from the surgical pathology archives and clinicopathological data were obtained from the medical database at Kyungpook National University Hospital. Immunohistochemical staining for AQP-1, AQP-3, and AQP-5 was performed on tissue microarrays comprising paired malignant and benign prostatic tissues...
November 5, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27793019/intravenous-administration-of-xenogenic-adipose-derived-mesenchymal-stem-cells-admsc-and-admsc-derived-exosomes-markedly-reduced-brain-infarct-volume-and-preserved-neurological-function-in-rat-after-acute-ischemic-stroke
#3
Kuan-Hung Chen, Chih-Hung Chen, Christopher Glenn Wallace, Chun-Man Yuen, Gour-Shenq Kao, Yi-Ling Chen, Pei-Lin Shao, Yung-Lung Chen, Han-Tan Chai, Kun-Chen Lin, Chu-Feng Liu, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
We tested the hypothesis that combined xenogenic (from mini-pig) adipose-derived mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy could reduce brain-infarct zone (BIZ) and enhance neurological recovery in rat after acute ischemic stroke (AIS) induced by 50-min left middle cerebral artery occlusion. Adult-male Sprague-Dawley rats (n = 60) were divided equally into group 1 (sham-control), group 2 (AIS), group 3 [AIS-ADMSC (1.2×106 cells)], group 4 [AIS-exosome (100μg)], and group 5 (AIS-exosome-ADMSC)...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27788793/tissue-expression-of-aquaporin-2-is-correlated-to-urine-output-and-allograft-function-in-sensitized-kidney-transplant-patients
#4
K Klein, S Rübenacker, S M Schaefer, L P Kihm, V Schwenger, S Macher-Goeppinger, P Schemmer, C Süsald, M Zeier, C Morath, L E Becker
BACKGROUND: Salt and water disturbances often occur during acute kidney allograft dysfunction that contribute to graft failure, but this condition has been poorly investigated in the alloreactivity setting. We evaluated the tissue expression of aquaporins (AQP1 and AQP2) and the epithelial sodium channel (ENAC) in kidney biopsy specimens from sensitized kidney transplant recipients. METHODS: Eighty-six biopsy specimens from 33 sensitized patients were divided into 3 groups according to clinical context: time-zero (n = 9), protocol (n = 9), and indication (n = 68)...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27777930/characterization-of-aqps-in-mouse-rat-and-human-colon-and-their-selective-regulation-by-bile-acids
#5
Jonathan Yde, Stephen Keely, Qi Wu, Johan F Borg, Natalia Lajczak, Aoife O'Dwyer, Peter Dalsgaard, Robert A Fenton, Hanne B Moeller
In normal individuals, the epithelium of the colon absorbs 1.5-2 l of water a day to generate dehydrated feces. However, in the condition of bile acid malabsorption (BAM), an excess of bile acids in the colon results in diarrhea. Several studies have attempted to address the mechanisms contributing to BAM induced by various bile acids. However, none have addressed a potential dysregulation of aquaporin (AQP) water channels, which are responsible for the majority of transcellular water transport in epithelial cells, as a contributing factor to the onset of diarrhea and the pathogenesis of BAM...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27746040/expression-of-aquaporin-7-and-aquaporin-9-in-tanycyte-cells-and-choroid-plexus-during-mouse-estrus-cycle
#6
A Yaba, B Sozen, B Suzen, N Demir
Tanycytes are special ependymal cells located in the ventrolateral wall and floor of the third ventricle having processes extending nuclei that regulate reproductive functions and around of vessels in median eminance. The aquaporins (AQPs) are a family of transmembrane proteins that transport water and glycerol. AQP-7 and -9 are permeable to other small molecules as glycerol and therefore called aquaglyceroporins. In this study, we aimed to show localization of AQP-7 and -9 in epithelial cells of choroid plexus and tanycytes during female mouse estrus cycle...
October 13, 2016: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/27707708/collecting-duct-specific-knockout-of-nitric-oxide-synthase-3-impairs-water-excretion-in-a-sex-dependent-manner
#7
Yang Gao, Deborah Stuart, Jennifer S Pollock, Takamune Takahishi, Donald E Kohan
Nitric oxide (NO) inhibits collecting duct (CD) Na(+) and water reabsorption. Mice with CD-specific knockout (KO) of NO synthase 1 (NOS1) have salt-sensitive hypertension. In contrast, the role of NOS3 in CD salt and water reabsorption is unknown. Mice with CD NOS3 KO were generated with loxP-flanked exons 9-12 (encodes the calmodulin binding site) of the NOS3 gene and the aquaporin-2 promoter-Cre transgene. There were no differences between control and CD NOS3 KO mice, irrespective of sex, in food intake, water intake, urine volume, urinary Na(+) or K(+) excretion, plasma renin concentration, blood pressure, or pulse during 7 days of normal (0...
November 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27687666/-propofol-suppresses-invasion-of-human-lung-cancer-a549-cells-by-down-regulating-aquaporin-3-and-matrix-metalloproteinase-9
#8
Hui-Jin Ye, Jian-Jie Bai, Pei-Pei Guo, Wei Wang, Chun-Shui Lin
OBJECTIVE: To investigate the effect of propofol on cell invasion and expressions of aquaporin-3 (APQ-3) and matrix metalloproteinase-9 (MMP-9) in human lung adenocarcinoma cancer A549 cells. METHOD: A549 cells were treated with propofol at the concentrations of 25, 50, and 100 µmol/L for 12 or 24 h. RT-PCR was used to detect the effect of propofol on AQP-3 mRNA level in A549 cells, and the effects of propofol treatments for 24 h on AQP-3 and MMP-9 protein expression and the invasive ability of A549 cells were assessed with Western blotting and Transwell assay, respectively...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27682231/increased-cerebrospinal-fluid-metalloproteinase-2-and-interleukin-6-are-associated-with-albumin-quotient-in-neuromyelitis-optica-their-possible-role-on-blood-brain-barrier-disruption
#9
Tomohiko Uchida, Masahiro Mori, Akiyuki Uzawa, Hiroki Masuda, Mayumi Muto, Ryohei Ohtani, Satoshi Kuwabara
BACKGROUND: Inflammation in neuromyelitis optica (NMO) is triggered by a serum antibody against the aquaporin-4 (AQP4). This process requires antibody penetration of the blood-brain barrier (BBB), but the mechanisms for BBB disruption in NMO remain unknown. OBJECTIVE: We examined whether changes in cerebrospinal fluid (CSF) and serum matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and cytokines are associated with BBB disruption in NMO...
September 28, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27668357/efficacy-and-safety-of-rituximab-therapy-in-neuromyelitis-optica-spectrum-disorders-a-systematic-review-and-meta-analysis
#10
Valentina Damato, Amelia Evoli, Raffaele Iorio
Importance: Neuromyelitis optica spectrum disorders (NMOSDs) are autoimmune astrocytopathies characterized by predominant involvement of the optic nerves and spinal cord. In most patients, an IgG autoantibody binding to astrocytic aquaporin 4, the principal water channel of the central nervous system, is detected. Rituximab, a chimeric monoclonal antibody specific for the CD20 B-lymphocyte surface antigen, has been increasingly adopted as a first-line off-label treatment for patients with NMOSDs...
September 26, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27635859/neuroprotective-effect-of-ischemic-preconditioning-via-modulating-the-expression-of-cerebral-mirnas-against-transient-cerebral-ischemia-in-diabetic-rats
#11
Ozge Altintas, Mehmet Ozgen Altintas, Meltem Kumas, Talip Asil
OBJECTIVES: In this study, we aimed to evaluate the effect of the Ischemic preconditioning (IPreC) on the expression profile of cerebral miRNAs against stroke by induced transient middle cerebral artery occlusion (MCAo) in diabetic rats. METHODS: Eighty male Spraque Dawley rats were allocated to eight groups. In order to evaluate the expression profile of miRNAs, we induced transient MCAo seven days after STZ-induced diabetes (DM). Also we performed IPreC 72 h before transient MCAo to assess whether IPreC could have a neuroprotective effect against ischemia-reperfusion injury...
September 16, 2016: Neurological Research
https://www.readbyqxmd.com/read/27623929/oleoylethanolamine-and-palmitoylethanolamine-modulate-intestinal-permeability-in-vitro-via-trpv1-and-ppar%C3%AE
#12
Mustafa A Karwad, Tara Macpherson, Bo Wang, Elena Theophilidou, Sarir Sarmad, David A Barrett, Michael Larvin, Karen L Wright, Jonathan N Lund, Saoirse E O'Sullivan
Cannabinoids modulate intestinal permeability through CB1 The endocannabinoid-like compounds oleoylethanolamine (OEA) and palmitoylethanolamine (PEA) play an important role in digestive regulation, and we hypothesized they would also modulate intestinal permeability. Transepithelial electrical resistance (TEER) was measured in human Caco-2 cells to assess permeability after application of OEA and PEA and relevant antagonists. Cells treated with OEA and PEA were stained for cytoskeletal F-actin changes and lysed for immunoassay...
September 13, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27603214/multiple-autoantibodies-and-neuromyelitis-optica-spectrum-disorders
#13
Chen Chen, Sun Xiaobo, Wang Yuge, Shu Yaqing, Fang Ling, Peng Lisheng, Lu Zhengqi, Qiu Wei
OBJECTIVE: To investigate the relationship between neuromyelitis optica spectrum disorder (NMOSD) and autoantibodies. METHODS: Blood samples of 108 NMOSD patients and 38 controls were collected from January 2012 to August 2014. Immunological parameters, including anti-aquaporin 4, antinuclear, anti-ribonucleoprotein, anti-SM, anti-SSA/Ro, anti-SSB/La and anti-ribosomal P-protein autoantibodies were examined. RESULTS: The NMOSD group exhibited a significantly higher percentage of anti-aquaporin 4 antibodies compared with the control group (76...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27586951/near-microsecond-human-aquaporin-4-gating-dynamics-in-static-and-alternating-external-electric-fields-non-equilibrium-molecular-dynamics
#14
Niall J English, José-A Garate
An extensive suite of non-equilibrium molecular-dynamics simulation has been performed for ∼0.85-0.9 μs of human aquaporin 4 in the absence and presence of externally applied static and alternating electric fields applied along the channels (in both axial directions in the static case, taken as the laboratory z-axis). These external fields were of 0.0065 V/Å (r.m.s.) intensity (of the same order as physiological electrical potentials); alternating fields ranged in frequency from 2.45 to 500 GHz. In-pore gating dynamics was studied, particularly of the relative propensities for "open" and "closed" states of the conserved arginines in the arginine/aromatic area (itself governed in no small part by external-field response of the dipolar alignment of the histidine-201 residue in the selectivity filter)...
August 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27569235/clinical-features-of-patients-with-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorders
#15
Hai Chen, Shi-Meng Liu, Xu-Xiang Zhang, Ya-Ou Liu, Si-Zhao Li, Zheng Liu, Hui-Qing Dong
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) was long believed to be an aggressive form of multiple sclerosis (MS). This study aimed to describe the clinical features of patients with MS and NMOSD to assist in differential diagnoses in clinical practice. METHODS: Data including the patients' serum and cerebrospinal fluid (CSF) tests, image findings, and clinical information from 175 patients with MS or NMOSD at Xuanwu Hospital, Capital Medical University from November 2012 to May 2014 were collected and analyzed retrospectively...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27552812/peritumoral-brain-edema-in-meningiomas-depends-on-aquaporin-4-expression-and-not-on-tumor-grade-tumor-volume-cell-count-or-ki-67-labeling-index
#16
Matthias Gawlitza, Eckhard Fiedler, Stefan Schob, Karl-Titus Hoffmann, Alexey Surov
PURPOSE: The aim of this study was to investigate to which degree the peritumoral brain edema in patients with meningiomas depends on aquaporin-4 (AQP4) expression, tumor grade, tumor volume, Ki-67 expression, and cell count. PROCEDURES: Thirty-three patients (25 women, 8 men; mean age 56.6 ± 16.0 years) with an intracranial meningioma underwent a standardized magnetic resonance (MR) examination prior to surgical resection. Edema indices (EIs) and tumor volumes were measured on the MR images...
August 23, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27549752/the-expression-patterns-of-aquaporin-9-vacuolar-h-atpase-and-cytokeratin-5-in-the-epididymis-of-the-common-vampire-bat
#17
Mariana M Castro, Bongki Kim, Eric Hill, Maria C Q Fialho, Luciano C H P Puga, Mariella B Freitas, Sylvie Breton, Mariana Machado-Neves
Desmodus rotundus is a vampire bat species that inhabits Latin America. Some basic aspects of this species' biology are still unknown, as the histophysiological characteristics of the male reproductive tract. Our study has focused on its epididymis, which is an important organ for performing a variety of functions, especially the sperm maturation and storage. The aim of this study was to identify principal, narrow, clear, and basal cells using cell-specific markers such as aquaporin 9 (AQP9), vacuolar H(+)-ATPase (V-ATPase), and cytokeratin 5 (KRT5)...
August 22, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27540000/is-pruritus-an-indicator-of-aquaporin-positive-neuromyelitis-optica
#18
Manjunath Netravathi, Jitender Saini, Anita Mahadevan, Bollampalli Hari-Krishna, Ravi Yadav, Pramod Kumar Pal, Parthasarathy Satishchandra
BACKGROUND: Recently, pruritus has been recognised as an important association with neuromyelitis optica spectrum disorders (NMOSD). OBJECTIVE: To determine the clinical and radiological characteristics of patients with NMOSD and pruritus. METHODS AND RESULTS: Among 57 consecutive patients with NMOSD, 15 (26.3% women) reported pruritus. All had aquaporin-4 (AQP4) antibodies. The mean age was 34.5 ± 9.1 years, age at onset was 31.3 ± 11...
August 18, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27538635/clinical-characteristics-of-disabling-attacks-at-onset-in-patients-with-neuromyelitis-optica-spectrum-disorder
#19
Jin Myoung Seok, Eun Bin Cho, Hye Lim Lee, Hye-Jin Cho, Ju-Hong Min, Kwang Ho Lee, Byoung Joon Kim
BACKGROUND: Individual attacks of neuromyelitis optica (NMO) are generally severe enough to cause disability even after the onset attack. We aimed to elucidate the clinical characteristics of disabling attacks at the onset of NMO. METHODS: We investigated the clinical characteristics at onset and at first relapse in patients with NMO or NMO spectrum disorder with seropositive for the anti-aquaporin-4 antibody. A disabling attack at onset (DAO) was defined as an onset attack in which, at best recovery (allowing up to one year), patients were unable to walk without assistance or were left functionally blind in at least one affected eye...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27507977/identification-of-drought-tolerant-mechanisms-in-maize-seedlings-based-on-transcriptome-analysis-of-recombination-inbred-lines
#20
Haowei Min, Chengxuan Chen, Shaowei Wei, Xiaoling Shang, Meiyun Sun, Ran Xia, Xiangguo Liu, Dongyun Hao, Huabang Chen, Qi Xie
Zea mays is an important crop that is sensitive to drought stress, but survival rates and growth status remain strong in some drought-tolerant lines under stress conditions. Under drought conditions, many biological processes, such as photosynthesis, carbohydrate metabolism and energy metabolism, are suppressed, while little is known about how the transcripts of genes respond to drought stress in the genome-wide rang in the seedling stage. In our study, the transcriptome profiles of two maize recombination inbred lines (drought-tolerant RIL70 and drought-sensitive RIL93) were analyzed at different drought stages to elucidate the dynamic mechanisms underlying drought tolerance in maize seedlings during drought conditions...
2016: Frontiers in Plant Science
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