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Aquaporin 9

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https://www.readbyqxmd.com/read/29770867/dietary-supplementation-with-an-amino-acid-blend-enhances-intestinal-function-in-piglets
#1
Dan Yi, Baocheng Li, Yongqing Hou, Lei Wang, Di Zhao, Hongbo Chen, Tao Wu, Ying Zhou, Binying Ding, Guoyao Wu
The traditionally classified nutritionally non-essential amino acids are now known to be insufficiently synthesized for maximal growth and optimal health in piglets. This study determined the effects of dietary supplementation with an amino acid blend (AAB; glutamate:glutamine:glycine:arginine:N-acetylcysteine = 5:2:2:1:0.5) on piglet growth performance and intestinal functions. Sixteen piglets (24-day-old) were randomly assigned to a corn and soybean meal-based diet supplemented with 0.99% alanine (isonitrogenous control) or 1% AAB...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29755491/roles-of-soybean-plasma-membrane-intrinsic-protein-gmpip2-9-in-drought-tolerance-and-seed-development
#2
Linghong Lu, Changhe Dong, Ruifang Liu, Bin Zhou, Chuang Wang, Huixia Shou
Aquaporins play an essential role in water uptake and transport in vascular plants. The soybean genome contains a total of 22 plasma membrane intrinsic protein (PIP) genes. To identify candidate PIPs important for soybean yield and stress tolerance, we studied the transcript levels of all 22 soybean PIPs. We found that a GmPIP2 subfamily member, GmPIP2;9, was predominately expressed in roots and developing seeds. Here, we show that GmPIP2;9 localized to the plasma membrane and had high water channel activity when expressed in Xenopus oocytes...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29729115/tissue-expression-of-aquaporine-3-in-different-sites-of-vitiligo-an-immunohistochemical-study
#3
S M Esmat, O A Zeid, D M Abdel Halim, M T Fawzy, M Abdel Latif, V Lazarova, M Assaf
The role of epidermal keratinocytes in the pathogenesis of vitiligo has been ignored despite the fact that both melanocytes and keratinocytes form one functional and structural unit. Aquaporin3 (AQP3), a glycerol water channel expressed in epithelial tissue, is involved in the regulation of keratinocyte proliferation, cell migration, and has a potential role in hypopigmentation in vitiligo. Normally, acral skin differs significantly from non-acral skin. Acral skin shows significantly lower hair follicle density, melanocyte density, Langerhans cell (LC) density, epidermal MHCII expression...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29724765/imaging-differences-between-neuromyelitis-optica-spectrum-disorders-and-multiple-sclerosis-a-multi-institutional-study-in-japan
#4
H Tatekawa, S Sakamoto, M Hori, Y Kaichi, A Kunimatsu, K Akazawa, T Miyasaka, H Oba, T Okubo, K Hasuo, K Yamada, T Taoka, S Doishita, T Shimono, Y Miki
BACKGROUND AND PURPOSE: Both clinical and imaging criteria must be met to diagnose neuromyelitis optica spectrum disorders and multiple sclerosis. However, neuromyelitis optica spectrum disorders are often misdiagnosed as MS because of an overlap in MR imaging features. The purpose of this study was to confirm imaging differences between neuromyelitis optica spectrum disorders and MS with visually detailed quantitative analyses of large-sample data. MATERIALS AND METHODS: We retrospectively examined 89 consecutive patients with neuromyelitis optica spectrum disorders (median age, 51 years; range, 16-85 years; females, 77; aquaporin 4 immunoglobulin G-positive, 93%) and 89 with MS (median age, 36 years; range, 18-67 years; females, 68; relapsing-remitting MS, 89%; primary-progressive MS, 7%; secondary-progressive MS, 2%) from 9 institutions across Japan (April 2008 to December 2012)...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29720337/insulin-promotes-preantral-follicle-growth-and-antrum-formation-through-temporal-expression-of-genes-regulating-steroidogenesis-and-water-transport-in-the-cat
#5
Chommanart Thongkittidilok, Ram Pratap Singh, Pierre Comizzoli, David Wildt, Nucharin Songsasen
The aims of the present study were to determine the effects of insulin, invitro, on: (1) the viability and growth of domestic cat ovarian follicles; (2) mRNA expression of genes regulating steroidogenesis (cytochrome P450 family 17 subfamily, A polypeptide 1 (Cyp17a1), cytochrome P450 family 19 subfamily, A polypeptide 1 (Cyp19a1) and steroidogenic acute regulatory protein (Star)) and water transport (aquaporins (AQPs) Aqp1, Aqp3, Aqp7, Aqp9); and (3) steroid production (17β-oestradiol (E2), progesterone (P4), androstenedione (A4))...
May 3, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29703264/cerebrospinal-fluid-mitochondrial-dna-in-neuromyelitis-optica-spectrum-disorder
#6
Kazuya Yamashita, Makoto Kinoshita, Katsuichi Miyamoto, Akiko Namba, Mikito Shimizu, Toru Koda, Tomoyuki Sugimoto, Yuki Mori, Yoshichika Yoshioka, Yuji Nakatsuji, Atsushi Kumanogoh, Susumu Kusunoki, Hideki Mochizuki, Tatsusada Okuno
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system. Although complement-dependent astrocyte damage mediated by anti-aquaporin 4 autoantibody (AQP4-Ab) is well acknowledged to be the core of NMOSD pathogenesis, additional inflammatory cascades may contribute to the establishment of lesion formation. Thus, in this study, we investigated the possible pathogenic role of immune-reactive mitochondrial DNA (mtDNA) in cerebrospinal fluid (CSF) of NMOSD patients...
April 27, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29627986/bacterial-cellulose-relieves-diphenoxylate-induced-constipation-in-rats
#7
Xichuan Zhai, Dehui Lin, Yan Zhao, Xingbin Yang
This study was to probe the effects of bacterial cellulose (BC) on diphenoxylate-induced constipation in rats. Administration with BC at 500 mg/kg·bw in diphenoxylate-induced constipation rats distinctly improved the carmine propulsion rate (83.5 ± 5.2%), shortened the defecating time of the first red feces (249.0 ± 23.3 min), and increased the weight of carmine red feces within 5 h (2.7 ± 1.3 g). The levels of aquaporins (AQP-2, AQP-3 and AQP-4) and inhibitory neurotransmitters (nitric oxide, nitric oxide synthetase, vasoactive intestinal peptide and arginine vasopressin) in the BC-treated groups reduced by 31...
April 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29626438/aquaporin-1-gene-deletion-affects-the-amniotic-fluid-volume-and-composition-as-well-as-the-expression-of-other-aquaporin-water-channels-in-placenta-and-fetal-membranes
#8
Hui Luo, Ailan Xie, Ying Hua, Jing Wang, Yanyun Liu, Xueqiong Zhu
OBJECTIVE: To explore the role of aquaporin 1 (AQP1) in regulation of amniotic fluid volume and composition. To investigate the effects of AQP1 gene knockout on expression of other aquaporin water channels (AQP3, AQP8 and AQP9) in placentas and fetal membranes. METHODS: Mice were sacrificed at 9.5, 13.5 and 16.5 gestational day (GD). Amniotic fluid volume, osmolality and composition, fetal membranes, placental and fetal weights as well as placenta areas were recorded in AQP1 homozygote conceptus group, heterozygote conceptus group and wild-type group, respectively...
April 4, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29606515/plasma-exchange-for-neuromyelitis-optica-spectrum-disorders-in-chinese-patients-and-factors-predictive-of-short-term-outcome
#9
Yujuan Jiao, Lei Cui, Weihe Zhang, Yeqiong Zhang, Wei Wang, Linwei Zhang, Wenxiong Tang, Jinsong Jiao
PURPOSE: The purposes of this article were to evaluate the short-term outcome of plasma exchange (PLEX) for neuromyelitis optica spectrum disorders (NMOSDs) in Chinese patients and to identify the factors predictive of a favorable response to therapy. METHODS: We retrospectively analyzed data from 29 Chinese patients with NMOSD. All patients received 2 to 7 sessions of PLEX every other day. Expanded Disability Status Scale (EDSS) scores were estimated at baseline, at relapse, and before and at follow-up after PLEX...
March 29, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29588233/postpartum-increases-in-cerebral-edema-and-inflammation-in-response-to-placental-ischemia-during-pregnancy
#10
Ahsia M Clayton, Qingmei Shao, Nina D Paauw, Ashtin B Giambrone, Joey P Granger, Junie P Warrington
Reduced placental blood flow results in placental ischemia, an initiating event in the pathophysiology of preeclampsia, a hypertensive pregnancy disorder. While studies show increased mortality risk from Alzheimer's disease, stroke, and cerebrovascular complications in women with a history of preeclampsia, the underlying mechanisms are unknown. During pregnancy, placental ischemia, induced by reducing uterine perfusion pressure (RUPP), leads to cerebral edema and increased blood-brain barrier (BBB) permeability; however whether these complications persist after delivery is not known...
March 24, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29564802/therapeutic-effect-of-ershen-pill-extract-on-pi-spleen-shen-kidney-yang-defi-ciency-induced-diarrhea-in-rat-model
#11
Xin Pan, Kang Xu, Rui Xiong, Zhi-Min Chen, Chang-Jiang Hu, Jian Feng, Wen-Bin Li
OBJECTIVE: To investigate whether Ershen Pill (ESP, ) could alleviate the symptom of Pi (Spleen)-Shen (Kidney) yang deficiency (PSYD)-induced diarrhea in rat model and explore its anti-diarrhea mechanism. METHODS: Seventy-fifi ve Sprague-Dawley rats were divided into 5 groups by a random number table, including control, positive, model, low-dose (LD) and high-dose (HD) ESP groups, 15 rats in each group. All the rats, except those in the control group, were developed PSYD induced-diarrhea based on its pathology and etiology...
March 21, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29556439/first-global-transcriptome-analysis-of-brown-algae-macrocystis-integrifolia-phaeophyceae-under-marine-intertidal-conditions
#12
Erika Salavarría, Sujay Paul, Patricia Gil-Kodaka, Gretty K Villena
To understand the physiological responses of the brown macroalga Macrocystis integrifolia during the marine tidal cycle, two RNA libraries were prepared from algal frond samples collected in the intertidal zone (0 m depth) and subtidal zone (10 m depth). Samples collected from intertidal zone during low tide was considered as abiotic stressed (MI0), while samples collected from subtidal zone was considered as control (MI10). Both RNA libraries were sequenced on Illumina NextSeq 500 which generated approx...
April 2018: 3 Biotech
https://www.readbyqxmd.com/read/29523003/similar-aquaporin9-and-mapk-expression-profiles-in-the-liver-of-types-1-and-2-diabetes-mellitus
#13
Jiaojiao Hou, Yuan Li, Xüxia Ren, Fei Gao, Yuqin Chen, Yaoxing Yi, Lili Kang, Yürui Luo, Mei Yang
Aquaporin-9 (AQP9) is an aquaglyceroporin that biophysically conducts water, glycerol, and other small solutes. AQP9 is expressed in hepatocytes on the sinusoidal surfaces of hepatocyte plates in the liver, where it is considered responsible for the glycerol uptake in gluconeogenesis. However, limited information is available on the expression and regulating mechanism of AQP9 in different hyperglycemia models. Thus, this study examined the expression patterns of AQP9 and mitogen-activated protein kinase (MAPK) in Types 1 and 2 diabetes mellitus (DM) to clarify the roles and regulating mechanism of AQP9 in gluconeogenesis...
March 9, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29495596/immunohistochemical-expression-of-aquaporin-1-in-fluoro-edenite-induced-malignant-mesothelioma-a-preliminary-report
#14
Giuseppe Angelico, Rosario Caltabiano, Carla Loreto, Antonio Ieni, Giovanni Tuccari, Caterina Ledda, Venerando Rapisarda
BACKGROUND: The immunohistochemical expression of aquaporin-1 (AQP1) in asbestos-related malignant pleural mesothelioma (MPM) is emerging as a useful prognostic indicator of improved survival. A significantly increased incidence of MPM in a small town in southern Italy was ascribed to exposure to fluoro-edenite (FE), a naturally occurring asbestos fiber. We investigated the immunohistochemical expression of AQP1 in patients affected by FE-related MPM; taking into consideration its suggested independent prognostic role, its possible correlation with clinicopathological parameters and patient outcome was also evaluated...
February 28, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29470571/prevalence-of-myelin-oligodendrocyte-glycoprotein-and-aquaporin-4-igg-in-patients-in-the-optic-neuritis-treatment-trial
#15
John J Chen, W Oliver Tobin, Masoud Majed, Jiraporn Jitprapaikulsan, James P Fryer, Jacqueline A Leavitt, Eoin P Flanagan, Andrew McKeon, Sean J Pittock
Importance: Autoantibodies to aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) are recently established biomarkers of autoimmune optic neuritis whose frequency and accompanying phenotype, especially for MOG-IgG, are still being characterized. The Optic Neuritis Treatment Trial (ONTT) was a well-known randomized clinical trial in optic neuritis; therefore, knowledge of the serostatus and accompanying phenotype of these patients would be useful to determine the frequency of these antibodies in patients presenting with typical monocular optic neuritis and their outcomes...
April 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29460396/lower-sperm-quality-and-testicular-and-epididymal-structural-impairment-in-adult-rats-exposed-to-rosuvastatin-during-prepuberty
#16
Gabriel Adan Araújo Leite, Marciana Sanabria, Marilia Martins Cavariani, Janete Aparecida Anselmo-Franci, Patrícia Fernanda Felipe Pinheiro, Raquel Fantin Domeniconi, Wilma De Grava Kempinas
The increase of obesity, bad eating habits and the lack of physical exercises are highly related to dyslipidemias. Rosuvastatin is a lipid-lowering drug and has been indicated to prevent cardiovascular diseases and to treat dyslipidemias due to its higher efficiency to reduce serum cholesterol concentrations. This study aimed to evaluate the reproductive adverse effects on sexual maturity due to rosuvastatin exposure in juvenile male rats during prepuberty. Three groups were randomly formed with newly weaned rats: control, whose rats received saline solution 0...
June 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29455395/anti-cancer-effect-of-aquaporin-5-silencing-in-colorectal-cancer-cells-in-association-with-inhibition-of-wnt-%C3%AE-catenin-pathway
#17
Wei Wang, Qing Li, Tao Yang, Dongsheng Li, Feng Ding, Hongzhi Sun, Guang Bai
Aquaporin 5 (AQP5) is a water channel protein that is over-expressed in many tumors. Elevated expression of AQP5 is associated with poor prognosis of colorectal cancer. Yet, whether AQP5 plays a role in epithelial-mesenchymal transition (EMT) of colorectal cancer has not been reported until now. Here we aim to investigate the function of AQP5 in the EMT process of colorectal cancer. We transfected HCT116 and SW480 cells with AQP5-specific shRNA and verified the knockdown efficiency through western blotting and real-time PCR...
April 2018: Cytotechnology
https://www.readbyqxmd.com/read/29455361/treatment-of-neuromyelitis-optica-with-rituximab-a-2-year-prospective-multicenter-study
#18
Philippe Cabre, M Mejdoubi, S Jeannin, H Merle, Y Plumelle, G Cavillon, D Smadja, R Marignier
OBJECTIVE: Neuromyelitis optica (NMO) is a very severe autoimmune disorder of the central nervous system. It affects young subjects and has a poor prognosis both on a functional and vital level. Therefore, it is imperative to reduce the frequency of relapses. The purpose of this study was to evaluate the clinical and neuroradiological effectiveness of rituximab (RTX) on active forms of NMO. METHODS: We conducted a 2-year open prospective multicenter study that included 32 patients treated with RTX at a dose of 375 mg/m2 /week for 1 month...
April 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29449936/function-of-aquaporins-in-sepsis-a-systematic-review
#19
REVIEW
Katharina Rump, Michael Adamzik
Background: Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic strategies is urgent. Promising drug targets or biomarkers may depict aquaporins (AQPs) as they regulate crucial key mechanisms of sepsis. Main body: Here we report on base of the current literature that several AQPs are involved in different physiological processes of sepsis. In immune system mainly AQPs 3, 5 and 9 seem to be important, as they regulate the migration of different immune cells...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29428877/new-insights-on-parkinson-s-disease-from-differentiation-of-sh-sy5y-into-dopaminergic-neurons-an-involvement-of-aquaporin4-and-9
#20
Rosanna Avola, Adriana Carol Eleonora Graziano, Giovanna Pannuzzo, Ferdaous Albouchi, Venera Cardile
The purpose of this research was to explore the behavior of aquaporins (AQPs) in an in vitro model of Parkinson's disease that is a recurrent neurodegenerative disorder caused by the gradual, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Because of postmortem studies have provided evidences for oxidative damage and alteration of water flow and energy metabolism, we carried out an investigation about AQP4 and 9, demonstrated in the brain to maintain water and energy homeostasis...
April 2018: Molecular and Cellular Neurosciences
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