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Poetic trial

Saskia Hullegie, Mandy Wootton, Theo J M Verheij, Emma Thomas-Jones, Janine Bates, Kerenza Hood, Micaela Gal, Nick A Francis, Paul Little, Michael Moore, Carl Llor, Timothy Pickles, David Gillespie, Nigel Kirby, Curt Brugman, Christopher C Butler
Background: Urine culture at the point of care minimises delay between obtaining the sample and agar inoculation in a microbiology laboratory, and quantification and sensitivity results can be available more rapidly in primary care. Objective: To identify the degree to which clinicians' interpretations of a point-of-care-test (POCT) urine culture (Flexicult™ SSI-Urinary Kit) agrees with laboratory culture in women presenting to primary care with symptoms of uncomplicated urinary tract infections (UTI)...
August 1, 2017: Family Practice
Pascal Gellert, Corrinne V Segal, Qiong Gao, Elena López-Knowles, Lesley-Ann Martin, Andrew Dodson, Tiandao Li, Christopher A Miller, Charles Lu, Elaine R Mardis, Alexa Gillman, James Morden, Manuela Graf, Kally Sidhu, Abigail Evans, Michael Shere, Christopher Holcombe, Stuart A McIntosh, Nigel Bundred, Anthony Skene, William Maxwell, John Robertson, Judith M Bliss, Ian Smith, Mitch Dowsett
Pre-surgical studies allow study of the relationship between mutations and response of oestrogen receptor-positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and blood from 60 patients (40 AI treated, 20 controls). In poor responders (based on Ki67 change), we find significantly more somatic mutations than good responders. Subclones exclusive to baseline or surgical cores occur in ∼30% of tumours...
November 9, 2016: Nature Communications
Elena López-Knowles, Qiong Gao, Maggie Chon U Cheang, James Morden, Joel Parker, Lesley-Ann Martin, Isabel Pinhel, Fiona McNeill, Margaret Hills, Simone Detre, Maria Afentakis, Lila Zabaglo, Andrew Dodson, Anthony Skene, Chris Holcombe, John Robertson, Ian Smith, Judith M Bliss, Mitch Dowsett
BACKGROUND: Gene expression is widely used for the characterisation of breast cancers. Variability due to tissue heterogeneity or measurement error or systematic change due to peri-surgical procedures can affect measurements but is poorly documented. We studied the variability of global gene expression between core-cuts of primary ER+ breast cancers and the impact of delays to tissue stabilisation due to sample X-ray and of diagnostic core cutting. METHODS: Twenty-six paired core-cuts were taken immediately after tumour excision and up to 90 minutes delay due to sample X-ray; 57 paired core-cuts were taken at diagnosis and 2 weeks later at surgical excision...
April 1, 2016: Breast Cancer Research: BCR
Marie Klintman, Mitchell Dowsett
The assessment of new therapies in the adjuvant setting in early breast cancer requires large numbers of patients and many years of follow-up for results to be presented. Therefore, the neoadjuvant study setting, which allows for early prediction of treatment response in smaller patient sets, has become increasingly popular. Ki67 is the most commonly used and extensively studied intermediate biomarker of treatment activity and residual risk in neoadjuvant trials on endocrine therapy, new biological therapies, and chemotherapy...
May 2015: Journal of the National Cancer Institute. Monographs
Janine Bates, Emma Thomas-Jones, Timothy Pickles, Nigel Kirby, Micaela Gal, Emily Bongard, Kerenza Hood, Nicolas Francis, Paul Little, Michael Moore, Kate Rumsby, Carlos Llor, Curt Burgman, Theo Verheij, David Cohen, Mandy Wootton, Robin Howe, Christopher C Butler
BACKGROUND: Urinary tract infections (UTI) are the most frequent bacterial infection affecting women and account for about 15% of antibiotics prescribed in primary care. However, some women with a UTI are not prescribed antibiotics or are prescribed the wrong antibiotics, while many women who do not have a microbiologically confirmed UTI are prescribed antibiotics. Inappropriate antibiotic prescribing unnecessarily increases the risk of side effects and the development of antibiotic resistance, and wastes resources...
2014: BMC Family Practice
Mitch Dowsett, Ian Smith, John Robertson, Laura Robison, Isabel Pinhel, Lindsay Johnson, Janine Salter, Anita Dunbier, Helen Anderson, Zara Ghazoui, Tony Skene, Abigail Evans, Roger A'Hern, Amanda Iskender, Maggie Wilcox, Judith Bliss
The preoperative setting is increasingly popular for the clinical investigation of hormonal agents and new biological drugs. The effectiveness of endocrine agents is well established for estrogen receptor-positive disease, and the emphasis in preoperative studies is on their combination with agents targeted at resistance mechanisms over 3 or more months. New agents are also being assessed for early evidence of clinical efficacy in shorter-term window-of-opportunity studies. The establishment of Ki67 as an intermediate marker of treatment benefit and of long-term outcome, with endocrine drugs, provides the opportunity for new trial designs with Ki67 as the primary endpoint...
2011: Journal of the National Cancer Institute. Monographs
Kimberley A Hoeksema, Aarthi Jayanthan, Todd Cooper, Lia Gore, Tanya Trippett, Jessica Boklan, Robert J Arceci, Aru Narendran
Despite significant progress made in the overall cure rate, the prognosis for relapsed and refractory malignancies in children remains extremely poor. Hence, there is an urgent need for studies that enable the timely selection of appropriate agents for Phase I clinical studies. The Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC) is systematically evaluating libraries of known and novel compounds for activity against subsets of high-risk pediatric malignancies with defined molecular aberrations for future clinical development...
2011: OncoTargets and Therapy
Albert Banerjee, Daphna Birenbaum-Carmeli
OBJECTIVE: To explore the relationship between the presentation of suffering and support for euthanasia in the British news media. METHOD: Data was retrieved by searching the British newspaper database LexisNexis from 1996 to 2000. Twenty-nine articles covering three cases of family assisted suicide (FAS) were found. Presentations of suffering were analysed employing Heidegger's distinction between technological ordering and poetic revealing. FINDINGS: With few exceptions, the press constructed the complex terrain of FAS as an orderly or orderable performance...
November 2007: Journal of Medical Ethics
William J Doyle, Deborah A Gentile, David P Skoner
In contradistinction to the poetically inspired disjunction between the name and quality of a rose recited by Juliet in the famous quote from Shakespeare's play, disease labels used in the medical sciences need to have exact meaning to ensure that they communicate an accurate diagnosis and a valid treatment approach. Above, we presented a consistent nosology for rhinitis consequent to infection. There, we argued that the term "rhinitis" should be used to describe the condition of nasal mucosal pathology and that the rSSC be used to describe the appreciated expression of that pathology...
2007: Clinical Allergy and Immunology
C J Summers
While the sexual temptation of Paradise Regained is tactful, it is also characteristically Miltonic in its daring. Despite its decorous presentation, the temptation is exceedingly bold in that it is not merely a heterosexual temptation but a homosexual one as well. Acknowledgement of the homosexual lure in the brief epic is essential to understanding the dynamics of the celebrated banquet scene and to appreciating the comprehensiveness of Milton's trial of the Son's humanity. Such a recognition also helps place in perspective the alleged misogyny of Paradise Regained, even as it also reveals the complexity of Milton's poetic technique, particularly his ability to work by indirection and implication and to exploit classical and biblical sources...
1997: Journal of Homosexuality
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