Read by QxMD icon Read

Chronotropic incompetency

Sara Peterson, Jennifer A Su, Jacqueline R Szmuszkovicz, Robert Johnson, Barbara Sargent
Pediatric HTs account for 13% of all HTs with >60% of recipients surviving at least 10 years post-HT. The purpose of this systematic review is to synthesize the literature on exercise capacity of pediatric HT recipients to improve understanding of the mechanisms that may explain the decreased exercise capacity. Six databases were searched for studies that compared the exercise capacity of HT recipients ≤21 years old with a control group or normative data. Sixteen studies were included. Pediatric HT recipients, as compared to controls or normative data, exhibit significantly higher resting HR, and at peak exercise exhibit significantly decreased HR, VO2 , power, work, minute ventilation, and exercise duration...
April 17, 2017: Pediatric Transplantation
Valentina Mantegazza, Anna Apostolo, Alfred Hager
Recently, the number of patients with congenital heart diseases reaching adulthood has been progressively increasing in developed countries and new issues are emerging regarding them: the evaluation of their capacity to cope with physical activity, and whether this knowledge can be used to optimize medical management. A symptom-limited cardiopulmonary exercise test has proven to be an essential tool because it can objectively evaluate the functional cardiovascular capacity of these patients, identify the pathological mechanisms of the defect (circulatory failure, shunts, pulmonary hypertension) and help prescribe an individualized rehabilitation program when needed...
April 4, 2017: Annals of the American Thoracic Society
S G Kanorskii, A F Sereda
OBJECTIVE: to compare efficacy of verapamil and amlodipine in treatment of chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction (EF) in patients with hypertensive disease (HD). MATERIAL AND METHODS: Patients with stage III HD, class II-III CHF, and LVEF more or equal 50% (n=167, age 48-70 years) underwent complex examination before and after 12 months of treatment with perindopril combined either with verapamil SR (n=85) or amlodipine (n=82)...
December 2016: Kardiologiia
Changwei Wu, Jian Guo, Hui Liu, Bigyan Pudasaini, Wenlan Yang, Qinhua Zhao, Lan Wang, Jinming Liu
We show by this study that a decrease in HRR1 in IPAH patients is associated with severe limitation of exercise capacity. HRR1 < 16 beats and CI just after completion of a CPET could be an indicator of poor prognosis.
2017: BioMed Research International
Hai-Jian Liu, Jian Guo, Qin-Hua Zhao, Lan Wang, Wen-Lan Yang, Jing He, Su-Gang Gong, Jin-Ming Liu
BACKGROUND: To study the relationship between chronotropic incompetence (CI) and disease severity and to assess the effect of CI on exercise capacity in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Arterial blood gas analysis, pulmonary function test and cardiopulmonary exercise testing were conducted in 60 patients with stable COPD and 45 healthy volunteers. CI was defined using the chronotropic response index (CRI = (peak heart rate-resting heart rate) / (220-age-resting heart rate)...
March 2017: American Journal of the Medical Sciences
Livia Goldraich, Heather J Ross, Farid Foroutan, Michael Walker, Juarez Braga, Michael A McDonald
BACKGROUND: Chronotropic incompetence (CI) in heart failure (HF) patients with cardiac resynchronization therapy (CRT) and activity sensors may vary according to exercise modality. We hypothesized that chronotropic response and exercise capacity differ when HF patients with CRT and heart rate (HR) adaptive pacing are exercised on cycloergometer versus treadmill. METHODS AND RESULTS: This is a crossover study in which stable HF patients with CRT and HR-adaptive pacing triggered by activity sensors underwent maximal symptom-limited cardiopulmonary exercise testing on both a cycloergometer and treadmill...
January 20, 2017: Journal of Cardiac Failure
Michel Cabrera Ortega, Hiram Tápanes Duamy, Dunia B Benítez Ramos
Chronic right ventricular (RV) apical pacing has been associated with deterioration of functional capacity and chronotropic incompetence during exercise testing in children. The effects of alternative pacing site on exercise performance in pediatric population remain unknown. We evaluated the influence of ventricular pacing site on exercise capacity in pediatric patients with complete congenital atrioventricular block requiring permanent pacemaker therapy. Sixty-four children paced from RV apex (n = 26), RV midseptum (n = 15) and left ventricular (LV) apex (n = 23) were studied cross-sectionally...
February 2017: Pediatric Cardiology
Yan Topilsky, Zach Rozenbaum, Shafik Khoury, Gregg S Pressman, Yaniv Gura, Jack Sherez, Avi Man, Jason Shimiaie, Sanford Edwards, Joshua Berookhim, Thierry Le Tourneau, Amir Halkin, Simon Biner, Gad Keren, Galit Aviram
Combining echocardiography and cardiopulmonary stress testing allows noninvasive assessment of hemodynamics, and oxygen extraction (A-VO2 difference). We evaluated mechanisms of effort intolerance in patients with heart failure with borderline (40% to 49%) left ventricular ejection fraction (EF) (HF and Borderline Ejection fraction). We included 89 consecutive patients with HF and Borderline Ejection fraction (n = 25; 63.6 ± 14 years, 64% men), control subjects (n = 22), patients with HF with preserved EF (n = 26; EF ≥50%), and patients with HF with reduced EF (n = 16; <40%)...
February 1, 2017: American Journal of Cardiology
Michal Laufer-Perl, Yaniv Gura, Jason Shimiaie, Jack Sherez, Gregg S Pressman, Galit Aviram, Simon Maltais, Ricki Megidish, Amir Halkin, Meirav Ingbir, Simon Biner, Gad Keren, Yan Topilsky
OBJECTIVES: This study sought to evaluate mechanisms of effort intolerance in patients with rheumatic mitral stenosis (MS). BACKGROUND: Combined stress echocardiography and cardiopulmonary testing allows assessment of cardiac function, hemodynamics, and oxygen extraction (A-Vo2 difference). METHODS: Using semirecumbent bicycle exercise, 20 patients with rheumatic MS (valve area 1.36 ± 0.4 cm(2)) were compared to 20 control subjects at 4 pre-defined activity stages (rest, unloaded, anaerobic threshold, and peak)...
November 10, 2016: JACC. Cardiovascular Imaging
Antoine Legendre, Aurore Guillot, Magalie Ladouceur, Damien Bonnet
BACKGROUND: Aerobic capacity (VO2 max) of patients with Fontan circulation (FC) is lowest within patients with congenital heart disease. The reasons have not been completely elucidated. METHODS: Twenty five young patients with non-failing FC underwent a cardiopulmonary test during an upright ramp cycling. By using a signal morphology impedance cardiography device (physioflow®), stroke volume (SV) was evaluated along with effort. The results were compared with paired healthy controls...
January 15, 2017: International Journal of Cardiology
Sébastien Hulo, Jocelyn Inamo, Aurélie Dehon, Olivier Le Rouzic, Jean-Louis Edme, Remi Neviere
PURPOSE: Metabolic-chronotropic relationship is the only concept that assesses the entire chronotropic function during exercise, as it takes into account individual fitness. To better understand interrelationships between chronotropic incompetence (CI), dynamic hyperinflation (DH) and exercise limitation among Global initiative for chronic Obstructive Lung Disease (GOLD) stages of chronic obstructive pulmonary disease (COPD) disease severity, we evaluated cardiopulmonary responses to symptom-limited cycle exercise in stable patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Hui Li, Jingbo Li, Xiaohong Zhou, Jianrong Zhao, Fengru Zhang, Liqun Wu, Hong Shen, Qing Wan, Jing Huang, Shungang Yang, Ping Wang
Heart failure patients have a high incidence of chronotropic incompetence (CI) that receives less clinical attention. This study assessed a method using wearable devices to identify CI in heart failure patients. Twenty-six heart failure patients (LVEF: 43.9  ±  5.7% with LVEF  ⩾40% in 19 patients; age: 52.8  ±  12.4 years, female patients  =  6) were enrolled. Each patient underwent symptom-limited treadmill maximal exercise testing during which the simultaneous recording of ECG Holter and physical activity using Actigraph was conducted...
October 18, 2016: Physiological Measurement
Alireza Khoshdel, Shane Carney, Saxon White, Alastair Gillies
INTRODUCTION: Kidney disease increases the risk of cardiovascular disease. The corollary of that observation should be that cardiovascular disease would not only increase the risk of kidney dysfunction, but also cause kidney damage, a concept not previously proposed. MATERIALS AND METHODS: Hemodynamic response to a graded exercise stress test was measured in 70 candidates to evaluate the association of heart rate and blood pressure change, heart rate reserve, chronotropic incompetence (percentage of achievement of maximal predicted heart rate), and circulatory power with development of kidney failure (glomerular filtration rate < 30 mL/min/1...
September 2016: Iranian Journal of Kidney Diseases
Rupert K Hung, Mouaz H Al-Mallah, Seamus P Whelton, Erin D Michos, Roger S Blumenthal, Jonathan K Ehrman, Clinton A Brawner, Steven J Keteyian, Michael J Blaha
Whether lower heart rate thresholds (defined as the percentage of age-predicted maximal heart rate achieved, or ppMHR) should be used to determine chronotropic incompetence in patients on beta-blocker therapy (BBT) remains unclear. In this retrospective cohort study, we analyzed 64,549 adults without congestive heart failure or atrial fibrillation (54 ± 13 years old, 46% women, 29% black) who underwent clinician-referred exercise stress testing at a single health care system in Detroit, Michigan from 1991 to 2009, with median follow-up of 10...
December 1, 2016: American Journal of Cardiology
Magda M Maia, Bruno Gualano, Ana L Sá-Pinto, Adriana M E Sallum, Rosa M R Pereira, Claudio A Len, Maria T A Terreri, Cassia M Barbosa, Hamilton Roschel, Clovis A Silva
OBJECTIVE: To assess aerobic capacity and cardiac autonomic modulation in juvenile fibromyalgia syndrome (JFM) patients at diagnosis in response to graded exercise text. METHODS: A multicenter cross-sectional study included 25 JFM patients and 25 healthy controls. Both groups participated only in physical education classes at school. A treadmill graded cardiorespiratory test was performed and the heart-rate (HR) response during exercise was evaluated by the chronotropic reserve (CR)...
December 2016: Seminars in Arthritis and Rheumatism
Bárbara Nascimento de Carvalho Klemz, Edgard Torres Dos Reis-Neto, Fábio Jennings, Usmary Sardinha Siqueira, Fábio Kadratz Klemz, Helder Henrique Costa Pinheiro, Emília Inoue Sato, Jamil Natour, Vera Lúcia Szejnfeld, Marcelo de Medeiros Pinheiro
OBJECTIVES: To evaluate the impact and risk factors associated with an abnormal exercise test (ET) in systemic inflammatory rheumatic disease (SIRD) patients before commencing supervised physical exercise. METHODS: A total of 235 SIRD patients were enrolled in three controlled clinical trials, including 103 RA, 42 SLE and 57 AS patients. The control group consisted of 231 healthy, sedentary subjects matched for age, gender and BMI. All performed an ET, according to Bruce's or Ellestad's protocol...
November 2016: Rheumatology
Pascal Delsart, Pauline Maldonado-Kauffmann, Mathieu Bic, Fanny Boudghene-Stambouli, Jonathan Sobocinski, Francis Juthier, Olivia Domanski, Augustin Coisne, Richard Azzaoui, Natacha Rousse, George Fayad, Thomas Modine, Stephan Haulon, Andre Vincentelli, Claire Mounier-Vehier, David Montaigne
BACK GROUND: Regular exercise at a safe level, i.e. 3-5 metabolic equivalents, is recommended to improve blood pressure control and quality of life even after aortic dissection, although aerobic exercise capacities in these patients are unexplored yet. METHODS: We prospectively collected data from 105 patients with a history of post aortic dissection referred for a cardiopulmonary exercise testing (CPX) aiming to guide exercise rehabilitation. RESULTS: The population was composed of 76% of male, with a mean age of 57...
September 15, 2016: International Journal of Cardiology
Carsten Walter Israel
Bradyarrhythmias cause symptoms such as syncope, dizziness, or exercise intolerance and lead to the implantation of > 100 000 pacemakers in Germany annually. They are caused either by sinus node dysfunction (sinus bradycardia, sinoatrial block, sinusarrest, preautomatic pauses in paroxysmal atrial fibrillation, chronotropic incompetence) or by atrioventricular (AV) conduction abnormalities (AV block, complex bundle branch block). Optimal therapy of bradycardia crucially depends on ECG documentation which frequently requires Holter monitoring in the case of intermittent bradycardia...
May 2016: Deutsche Medizinische Wochenschrift
Haqeel A Jamil, John Gierula, Maria F Paton, Roo Byrom, Judith E Lowry, Richard M Cubbon, David A Cairns, Mark T Kearney, Klaus K Witte
BACKGROUND: Limited heart rate (HR) rise (HRR) during exercise, known as chronotropic incompetence (CI), is commonly observed in chronic heart failure (CHF). HRR is closely related to workload, the limitation of which is characteristic of CHF. Whether CI is a causal factor for exercise intolerance, or simply an associated feature remains unknown. OBJECTIVES: This study sought to clarify the role of the HR on exercise capacity in CHF. METHODS: This series of investigations consisted of a retrospective cohort study and 2 interventional randomized crossover studies to assess: 1) the relationship between HRR and exercise capacity in CHF; and 2) the effect of increasing and lowering HR on exercise capacity in CHF as assessed by symptom-limited treadmill exercise testing and measurement of peak oxygen consumption in patients with CHF due to left ventricular systolic dysfunction...
April 26, 2016: Journal of the American College of Cardiology
Adolfo Fontenla, Rafael Salguero, Jose B Martinez-Ferrer, Anibal Rodriguez, Javier Alzueta, Enrique Garcia, Nuria Basterra, Rafael Romero, Joaquin Fernandez DE LA Concha, Xavier Viñolas, Julian Villacastin, Maria Lopez-Gil, Fernando Arribas
BACKGROUND: Atrial rate-responsive pacing (RRP) has proved to be safe in pacemaker recipients with chronotropic incompetence. Although RRP is available in all current implantable cardioverter defibrillators (ICDs), the outcomes of this pacing mode in ICD patients are unknown. The aim is to evaluate the relationship between atrial RRP and atrial arrhythmias in ICD recipients. METHODS: Dual-chamber and triple-chamber ICD patients were included in this multicenter cohort study...
June 2016: Pacing and Clinical Electrophysiology: PACE
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"