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https://www.readbyqxmd.com/read/29155976/description-of-a-mass-poisoning-in-a-rural-district-in-mozambique-the-first-documented-bongkrekic-acid-poisoning-in-africa
#1
Eduardo Samo Gudo, Kyla Cook, Amelia M Kasper, Alfredo Vergara, Cristolde Salomão, Fernanda Oliveira, Hamida Ismael, Cristovão Saeze, Carla Mosse, Quinhas Fernandes, Sofia Omar Viegas, Cynthia S Baltazar, Timothy J Doyle, Ellen Yard, Alaina Steck, Mayda Serret, Travis M Falconer, Sara E Kern, Jennifer L Brzezinski, James A Turner, Brian L Boyd, Ilesh V Jani
Background: On January 9, 2015, in a rural town in Mozambique, over 230 people became sick and 75 died from an illness linked to drinking pombe, a traditional alcoholic beverage. Methods: An investigation was conducted to identify cases and determine the cause of the outbreak. A case was defined as any resident of Chitima who developed any new or unexplained neurologic, gastrointestinal, or cardiovascular symptom from January 9 at 6:00 a.m. through January 12. We conducted medical record reviews; healthcare worker and community surveys; anthropological and toxicological investigations of local medicinal plants and commercial pesticides; and laboratory testing of the suspect and control pombe...
November 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29155960/occupational-medicine-specialist-referral-triggers-mixed-methods-analysis-of-teleconsult-cases
#2
J L Eaton, A Mohammad, D C Mohr, D J Brustein, S R Kirkhorn
Background: Qualitative analyses can yield critical lessons for learning organizations in healthcare. Few studies have applied these techniques in the field of occupational and environmental medicine (OEM). Aims: To describe the characteristics of complex cases referred for OEM subspecialty evaluation and variation by referring provider's training. Methods: Using a mixed methods approach, we conducted a content analysis of clinical cases submitted to a national OEM teleconsult service...
November 16, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29155935/early-and-late-outcomes-of-open-repair-for-dissecting-aneurysms-of-the-descending-or-thoraco-abdominal-aorta
#3
Atsushi Omura, Kenji Minatoya, Jiro Matsuo, Yosuke Inoue, Yoshimasa Seike, Kyokun Uehara, Hiroaki Sasaki, Hitoshi Matsuda, Junjiro Kobayashi
OBJECTIVES: Although open repair is the standard surgical option for dissecting descending thoracic aneurysms (DTAs) and thoraco-abdominal aorta aneurysms (TAAAs), it remains a significant challenge with considerable perioperative morbidity and mortality. We retrospectively analysed early and late outcomes of open repair for these aortic aneurysms. METHODS: Early and late outcomes were investigated for 223 consecutive patients who underwent open repair for dissecting DTA or TAAA between January 2003 and December 2014 (mean age 55 ± 16 years)...
October 9, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29155066/unruptured-versus-ruptured-avms-outcome-analysis-from-a-multicentric-consecutive-series-of-545-surgically-treated-cases
#4
Marco Cenzato, Fulvio Tartara, Giuseppe D'Aliberti, Carlo Bortolotti, Francesco Cardinale, Gianfranco Ligarotti, Alberto Debernardi, Alessia Fratianni, Edoardo Boccardi, Roberto Stefini, Francesco Zenga, Riccardo Boccaletti, Andrea Lanterna, Giacomo Pavesi, Paolo Ferroli, Carmelo Sturiale, Alessandro Ducati, Andrea Cardia, Maurizio Piparo, Luca Valvassori, Mariangela Piano
Recent literature strongly challenged indications to perform preventive surgery in unruptured AVM. claiming that invasive AVM treatment is associated with a significant risk of complications and thus conservative management may be a preferable alternative in many patients. On the other hand, the recent improvement of surgical instrumentation and treatment strategies (both surgical and interventional) yielded much better outcomes than those achieved only a decade ago. Therefore, even among the specialists, a wide variety of opinions, concerning the treatment of unruptured AVM, can be found...
November 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155065/intradural-extramedullary-cervical-cord-lipoma-case-report-and-literature-review
#5
Dimitrios Panagopoulos, Georgios Markogiannakis, Michael Koutzoglou
BACKGROUND: Spinal lipomas are generally thought to occur as a result of failed primary neurulation. Failed primary neurulation allows invasion of mesenchymal tissue of mesodermic origin into the neural structure, leading to the formation of a spinal lipoma. Despite most spinal lipomas being regarded as the result of failed primary neurulation, some confusion in terms of the embryogenesis of spinal lipomas remains. Recently, a novel classification of spinal lipomas based on embryonic changes seen during primary and secondary neurulation was has been proposed...
November 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155000/role-of-cerebrolysin-%C3%A2-in-cervical-spondylotic-myelopathy-patients-a-prospective-randomized-study
#6
Ahmad Fouad Abdelbaki Allam, Tarek Abdalla Ahmed Abotakia, Wael Koptan
BACKGROUND CONTEXT: Cerebrolysin(®) is a mixture containing 85% free amino acids and 15% biologically active low-molecular weight peptides, that is believed to mimic the effects of endogenous neurotrophic factors to interact with the pathological process cascade of neurodegenerative diseases. No study has examined the effect of Cerebrolysin(®) on the cervical myelopathic patients. PURPOSE: To evaluate the effect of cerebrolysin(®) as a conservative modality on cervical spondylotic myelopathic patients...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154998/intraoperative-vertebroplasty-during-surgical-decompression-and-instrumentation-for-aggressive-vertebral-hemangiomas-a-retrospective-study-of-39-patients-and-review-of-the-literature
#7
Ben Wang, Song Bo Han, Liang Jiang, Xiao Guang Liu, Shao Min Yang, Na Meng, Feng Wei, Zhong Jun Liu
BACKGROUND CONTEXT: Aggressive (Enneking Stage 3, S3) vertebral hemangiomas (VHs) are rare, which might require surgery. However, the choice of surgery for S3 VHs remains controversial because of the rarity of these lesions. PURPOSE: We reported our experience of treating S3 VHs, and evaluated the effectiveness and safety of intraoperative vertebroplasty during decompression surgery for S3 VHs. STUDY DESIGN: This is a retrospective study. PATIENT SAMPLE: Thirty-nine patients with a definitive pathological diagnosis of aggressive VHs who underwent primary decompression surgery in our department were included in this study...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154997/kyphoplasty-for-osteoporotic-vertebral-fractures-with-posterior-wall-injury
#8
Ahmed Shawky, Ali Ezzati, Ramachandran Govindasamy, Branko Krajnovic, Belal El-Nady, Galal Zaki Said
BACKGROUND: Cement augmentation techniques are standard treatments for osteoporotic vertebral fractures. Compared to vertebroplasty, kyphoplasty is associated with lower rates of cement leak and better deformity correction, however, posterior wall fractures are relative, but not absolute, contraindications for both techniques and hence treatment practices vary among spine centers. PURPOSE: The primary aim of this study was to assess our center's incidence of posterior cement leakage in osteoporotic vertebral fractures with posterior wall injury treated by balloon kyphoplasty...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29153996/clinical-presentation-of-anti-n-methyl-d-aspartate-receptor-and-anti-voltage-gated-potassium-channel-complex-antibodies-in-children-a-series-of-24-cases
#9
Bahadir Konuskan, Mirac Yildirim, Haluk Topaloglu, Ilknur Erol, Ulkuhan Oztoprak, Huseyin Tan, Rahsan Gocmen, Banu Anlar
OBJECTIVE: The symptomatology and paraclinical findings of antibody-mediated encephalitis, a relatively novel disorder, are still being characterized in adults and children. A high index of suspicion is needed in order to identify these cases among children presenting with various neurological symptoms. The aim of this study is to examine the clinical, demographic and laboratory findings and outcome of children with anti-NMDAR and anti-VGKC encephalitis for any typical or distinctive features...
November 7, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29153916/a-case-with-cmtx1-disease-showing-transient-ischemic-attack-like-episodes
#10
Zehra Aktan, Nihan Hande Akcakaya, Pinar Tekturk, Engin Deniz, Bahar Koyuncu, Zuhal Yapici
Charcot-Marie-Tooth (CMT) disease is a hereditary neurologic disease which affects the sensorial and motor fibers of the peripheral nerves. CMTX1 is an X-linked dominantly inherited subtype of CMT and is caused by mutations in gap junction beta 1 gene (GJB1). A small proportion of GJB1 mutations are associated with recurrent central nervous system findings. We describe a 15-year-old male patient with CMTX1 who had stroke-like findings along with foot deformities and peripheral neuropathy. Strokes and stroke-like attacks are rarely seen in children and adolescents...
November 9, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29153596/the-aging-neurosurgeon-when-is-enough-enough-attitudes-toward-ceasing-practice-and-testing-in-late-career
#11
Maya A Babu, Linda M Liau, Robert J Spinner, Fredric B Meyer
OBJECTIVE: To present the first wide-scale survey to assess perceptions of testing the aging neurosurgeon. PATIENTS AND METHODS: This study included 4899 neurosurgeons, 2435 American Board of Neurological Surgery Diplomates participating in Maintenance of Certification (MOC), 1440 Diplomates certified before 1999 (grandfathered), and 1024 retired Diplomates. We developed an online confidential survey conducted from March 1, 2016, to May 31, 2016. We received 1449 responses overall (30% response rate)...
November 14, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29153460/real-world-procedural-and-30-day-outcome-using-the-portico-transcatheter-aortic-valve-prosthesis-a-large-single-center-cohort
#12
Andrea Denegri, Fabian Nietlispach, Jan Kottwitz, Gabor Suetsch, Philipp Haager, Hector Rodriguez, Maurizio Taramasso, Slayman Obeid, Francesco Maisano
BACKGROUND: Published procedural and short-term outcome of the Portico valve for Transcatheter Aortic Valve Implantation (TAVI) is limited. We report a single-center patient series assessing procedural and 30-day outcome of this device. METHODS AND RESULTS: Procedural and 30-day follow-up data were prospectively collected from a consecutive series of 73 patients (80.7±6.9years, 45% male, mean STS score: 4.8±3.9) with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)...
November 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29153066/-age-related-prevalence-of-toxoplasmosis-among-pregnant-women-in-hatay-estimation-depending-on-model
#13
Meryem Çetin, Şirin Çetin
Toxoplasmosis, caused by the obligate intracellular protozoan Toxoplasma gondii, is a common parasitic infection affecting approximately one-third of the world population. T.gondii infections are usually acquired by ingesting raw or insufficiently cooked meat and from unwashed fruits and vegetables contaminated with soil or water with cat feces. Primary infection acquired during pregnancy can cause severe congenital abnormalities in the fetus such as neurologic and ocular malformations, abortion, or stillbirth according to the degree of infection...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29152520/a-case-of-escherichia-coli-hemolytic-uremic-syndrome-in-a-10-year-old-male-with-severe-neurologic-involvement-successfully-treated-with-eculizumab
#14
Malia Rasa, James Musgrave, Keith Abe, Len Tanaka, Konstantine Xoinis, Bruce Shiramizu, Gretchen Foskett, Rhiana Lau
Hemolytic uremic syndrome (HUS) can be classified as typical and atypical, and the treatment recommendations currently differ between the 2 types. Eculizumab is recommended as first-line treatment for atypical HUS; however, its use in typical HUS has been controversial. We report a case of a 10-year-old male with severe neurologic impairment who was successfully treated with eculizumab, which was started 4 days after onset of neurologic symptoms. Our case supports the use of eculizumab in typical HUS with neurologic involvement, even when given later in the course, as the pathophysiology of typical HUS has been shown to involve activation of the complement pathway, similar to atypical HUS...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29152469/eyebrow-incision-for-surgical-evacuation-of-a-lobar-intracerebral-hematoma-with-a-novel-endoport-system
#15
Dale Ding, Colin J Przybylowski, Robert M Starke, R Webster Crowley, Kenneth C Liu
Large lobar intracerebral hemorrhages (ICHs) can cause rapid neurological deterioration, and affected patients have low rates of survival and functional independence. Currently, the role of surgical intervention in the management patients with lobar ICHs is controversial. Minimally invasive technologies have been developed which may potentially decrease the operative morbidity of ICH surgery. The aim of this case report is to describe the technical aspects of the use of a novel minimally invasive endoport system, the BrainPath (NICO, Indianapolis, IN, USA), through an eyebrow incision for evacuation of a large lobar hematoma...
June 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29152274/a-case-of-successful-bystander-cardiopulmonary-resuscitation-of-an-adult-with-bland-white-garland-syndrome
#16
Hidetada Fukuoka, Tetsuya Watanabe, Yukinori Shinoda, Kuniyasu Ikeoka, Tomoko Minamisaka, Hirooki Inui, Keisuke Ueno, Soki Inoue, Kentaro Mine, Koichi Toda, Yoshiki Sawa, Shiro Hoshida
In Japan and worldwide, the increase in educational interventions about resuscitation training significantly increases favorable neurological survival in out-of-hospital cardiopulmonary arrest cases treated with bystander cardiopulmonary resuscitation (BCPR) each year. This case with Bland-White-Garland syndrome having high-quality BCPR by nurses demonstrates the importance of education about BCPR.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29152209/case-control-study-hyperbaric-oxygen-treatment-of-mild-traumatic-brain-injury-persistent-post-concussion-syndrome-and-post-traumatic-stress-disorder
#17
Paul G Harch, Susan R Andrews, Edward F Fogarty, Juliette Lucarini, Keith W Van Meter
Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epidemic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. Thirty military subjects aged 18-65 with PPCS with or without PTSD and from one or more blast-induced mild-moderate traumatic brain injuries that were a minimum of 1 year old and occurred after 9/11/2001 were studied...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29151092/conversion-factitious-disorder-and-malingering-a-distinct-pattern-or-a-continuum
#18
Silvio Galli, Laurent Tatu, Julien Bogousslavsky, Selma Aybek
This chapter is aimed at highlighting the recent findings concerning physiopathology, diagnosis, and management of conversion, factitious disorder, and malingering. Conversion disorder is the unintentional production of neurological symptom, whereas malingering and factitious disorder represent the voluntary production of symptoms with internal or external incentives. They have a close history and this has been frequently confounded. Practitioners are often confronted to medically unexplained symptoms; they represent almost 30% of neurologist's consultation...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29150902/wieacker-wolff-syndrome-with-associated-cleft-palate-in-a-female-case
#19
Natalie D Godfrey, Samandar Dowlatshahi, Madelena M Martin, Douglas M Rothkopf
Wieacker-Wolff syndrome is a rare congenital syndrome with few reported cases in the current literature. It is traditionally described in males as an X-linked recessive disorder associated with congenital contractures of the feet, progressive neurologic muscular atrophy, and intellectual delay caused by ZC4H2 mutations. The purpose of this paper is to present a female individual with a classic phenotype and cleft palate, a previously undescribed finding in this syndrome. Recent reports have demonstrated that females are rarely severely affected and phenotypic expression is difficult to predict [Zanzottera et al...
November 17, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29150325/ilex-paraguariensis-potential-antioxidant-on-aluminium-toxicity-in-an-experimental-model-of-alzheimer-s-disease
#20
Pâmela M Bortoli, Carla Alves, Eduarda Costa, Ana Paula Vanin, Jéssica R Sofiatti, Diego P Siqueira, Rogério M Dallago, Helen Treichel, Gean Delise L P Vargas, Rosilene R Kaizer
Ilex paraguariensis, yerba mate is a native plant from the southern region of Brazil. Studies showed that yerba mate has an antioxidant potential, which could help to reduce the risk of developing neurodegenerative diseases, as Alzheimer's Disease (AD). It's known that I. paraguariensis grows in acid soils with aluminium (Al), which is bioavailable in these soils. Al has a neurotoxic potential related with the progression of neurological disorders. This study aim was to evaluate the potential of I. paraguariensis in the etiology of AD using strains of Caenorhabditis elegans and the concentration of Al and antioxidants in the yerba mate extract...
November 7, 2017: Journal of Inorganic Biochemistry
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