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Bradycardia

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https://www.readbyqxmd.com/read/28345730/electrocardiographic-abnormalities-in-treatment-na%C3%A3-ve-hiv-subjects-in-south-east-nigeria
#1
Innocent Chukwuemeka Okoye, Ernest Ndukaife Anyabolu
BACKGROUND: Cardiac complications of human immunodeficiency virus (HIV) infection are important causes of morbidity and mortality. We set out to determine the electrocardiographic (ECG) abnormalities in treatment-naïve HIV-positive patients in Enugu, south-east Nigeria. METHODS: This was a cross-sectional study involving 250 HIV-positive and 200 HIV-negative subjects. Demographic and anthropometric data, relevant investigations and ECG results were compared between the groups...
March 23, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28345212/cardiac-iodine-123-metaiodobenzylguanidine-scintigraphy-may-be-useful-to-identify-pathologic-from-physiologic-sinus-bradycardia
#2
Akihiro Sunaga, Masaharu Masuda, Masashi Fujita, Osamu Iida, Takashi Kanda, Yasuhiro Matsuda, Takakazu Morozumi, Toshiaki Mano, Masaaki Uematsu
BACKGROUND: Sinus bradycardia includes pathologic sick sinus syndrome (SSS) and physiologic bradycardia such as athletes' heart. Pacemaker implantation is indicated for patients with symptomatic SSS; however, the indication remains difficult to determine in those with mild and/or unspecific symptoms. The sympathetic tone is increased in response to reduced cardiac output in SSS, whereas excessive vagal tone has been seen in physiological bradycardia. We sought to determine if cardiac iodine-123-metaiodobenzylguanidine scintigraphy ((123) I-MIBG) was useful in differentiating pathologic from physiologic sinus bradycardia...
March 27, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28343657/bradycardia-associated-with-prednisolone-in-children-with-severe-kawasaki-disease
#3
Akito Nagakura, Yoshihiko Morikawa, Hiroshi Sakakibara, Masaru Miura
OBJECTIVE: To identify the prevalence of bradycardia associated with use of prednisolone in patients with Kawasaki disease and analyze the association between bradycardia and responsiveness to intravenous immunoglobulin (IVIG). STUDY DESIGN: We performed a retrospective cohort study of 176 patients with severe Kawasaki disease admitted to the Tokyo Metropolitan Children's Medical Center between March 2010 and December 2015. The group treated with IVIG plus prednisolone therapy from February 2012 was compared with the control group who received IVIG monotherapy before this date...
March 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28343653/swallow-induced-syncope-and-carotid-sinus-hypersensitivity-coincident-or-associated-conditions
#4
Eed Abu Zaid, Moti Haim, Hilmi Alnsasra, Yuval Konstantino
Swallow induced syncope is a rare clinical condition which is thought to result from an abnormal vagal reflex leading to bradycardia and cerebral hypoperfusion. It mostly occurs in patients with organic or functional disorders of the esophagus, and often requires permanent pacemaker implantation, along with treatment of the underlying esophageal pathology. In the following case, we report of a 71-year-old male with achalasia post per oral endoscopic myectomy, who presented with syncope and documented AV-block while eating solid food...
March 14, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28341362/sinus-bradycardia-in-habitual-cocaine-users
#5
Sona M Franklin, Sudarone Thihalolipavan, John M Fontaine
Common physiological manifestations of cocaine are related to its adrenergic effects, due to inhibition of dopamine and norepinephrine uptake at the postsynaptic terminal. Few studies have documented bradycardia secondary to cocaine use, representing the antithesis of its adrenergic effects. We assessed the prevalence of sinus bradycardia (SB) in habitual cocaine users and postulated a mechanism for this effect. One hundred sixty-two patients with a history of cocaine use were analyzed and compared with age- and gender-matched controls...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28339703/marked-bradycardia-elicited-during-pulmonary-vein-isolation-not-a-sign-of-success-authors-reply
#6
Georgios Giannopoulos, Vasiliki Panagopoulou, Spyridon Deftereos
No abstract text is available yet for this article.
February 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28336445/mortality-associated-characteristics-of-traumatic-brain-injury-patients-at-the-university-teaching-hospital-of-kigali-rwanda
#7
Elizabeth Krebs, Charles J Gerardo, Lawrence P Park, Joao Ricardo Nickenig Vissoci, Jean Claude Byiringiro, Fidele Byiringiro, Stephen Rulisa, Nathan Thielman, Catherine Staton
OBJECTIVE: Traumatic Brain Injury (TBI) is a leading cause of death and disability. TBI patients in low and middle- income countries have worse outcomes than those in high-income countries. We aimed to evaluate important clinical indicators associated with mortality for TBI patients at the University Teaching Hospital of Kigali (UTHK) Kigali, Rwanda. METHODS: Prospective consecutive sampling of TBI patients presenting to UTHK Accident and Emergency Department were screened for inclusion criteria: reported head trauma, alteration in consciousness, headache, or visible head trauma...
March 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28333936/adenosine-for-postoperative-analgesia-a-systematic-review-and-meta-analysis
#8
Xin Jin, Weidong Mi
PURPOSE: Perioperative infusion of adenosine has been suggested to reduce the requirement for inhalation anesthetics, without causing serious adverse effects in humans. We conducted a meta-analysis of randomized controlled trials evaluating the effect of adenosine on postoperative analgesia. METHODS: We retrieved articles in computerized searches of Scopus, Web of Science, PubMed, EMBASE, and Cochrane Library databases, up to July 2016. We used adenosine, postoperative analgesia, and postoperative pain(s) as key words, with humans, RCT, and CCT as filters...
2017: PloS One
https://www.readbyqxmd.com/read/28331443/pacemaker-use-following-heart-transplantation
#9
Hari R Mallidi, Michael Bates
BACKGROUND: The incidence of permanent pacemaker implantation after orthotopic heart transplantation has been reported to be 2%-24%. Transplanted hearts usually exhibit sinus rhythm in the operating room following reperfusion, and most patients do not exhibit significant arrhythmias during the postoperative period. However, among the patients who do exhibit abnormalities, pacemakers may be implanted for early sinus node dysfunction but are rarely used after 6 months. Permanent pacing is often required for atrioventricular block...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28330804/cardiac-arrest-attributable-to-dysfunction-of-the-autonomic-nervous-system-after-traumatic-cervical-spinal-cord-injury
#10
Sei Won Kim, Chan Joo Park, Kyungil Kim, Yoon-Chung Kim
Bradycardia is the most common form of dysrhythmia developing after disruption of the sympathetic pathway by a spinal cord injury (SCI), and it can have fatal consequences, including cardiac arrest. Here, we report a case of cardiac arrest developing after cervical SCI attributable to sympathetic hypoactivity. A 26-year-old male pedestrian was admitted after a traffic accident. Radiologically, fractures were apparent at the C6-7 bilateral articular facets, and cord contusion with hemorrhage was evident at C4-7...
February 24, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28329095/congestive-heart-failure-more-common-as-well-as-an-important-cardiovascular-outcome
#11
Anil Pareek
Hydroxychloroquine, due to its multifaceted pleiotropic benefits including anti-inflammatory effects has great potential in reducing cardiovascular (CV) morbidity and mortality. CV outcome data of hydroxychloroquine is available through 2 retrospective studies in rheumatoid arthritis patients, both of which have not considered congestive heart failure (CHF) as an outcome measure. CHF is an important CV outcome and is more common than myocardial infarction and stroke; and increased age is associated with increased risk of CHF...
December 20, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28327633/cardiac-drug-drug-interaction-between-hcv-ns5b-pronucleotide-inhibitors-and-amiodarone-is-determined-by-their-specific-diastereochemistry
#12
Armando Lagrutta, Christopher P Regan, Haoyu Zeng, John P Imredy, Kenneth Koeplinger, Pierre Morissette, Liping Liu, Gordon Wollenberg, Christopher Brynczka, José Lebrón, Joseph DeGeorge, Frederick Sannajust
Severe bradycardia/bradyarrhythmia following coadministration of the HCV-NS5B prodrug sofosbuvir with amiodarone was recently reported. Our previous preclinical in vivo experiments demonstrated that only certain HCV-NS5B prodrugs elicit bradycardia when combined with amiodarone. In this study, we evaluate the impact of HCV-NS5B prodrug phosphoramidate diastereochemistry (D-/L-alanine, R-/S-phosphoryl) in vitro and in vivo. Co-applied with amiodarone, L-ala,SP prodrugs increased beating rate and decreased beat amplitude in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), but D-ala,RP produgs, including MK-3682, did not...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325719/near-death-by-milk-of-magnesia
#13
Ahmed Alaini, Carlos A Roldan, Karen Servilla, Elizabeth Sage Colombo
We report a case of hypermagnesemia associated with the use of milk of magnesia in a male patient with end-stage renal disease. After experiencing nausea and vomiting, he developed severe bradycardia and then asystole. Resuscitation efforts were successful; however, he developed atrial fibrillation with severe widening of the QRS and diffuse ST elevation, hypothermia, hypotension and apnoea requiring intubation. Initial diagnoses included ST-elevation myocardial infarction, cardiogenic and/or septic shock and hyperkalaemia...
March 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28323584/evidence-for-gz-adaptation-observed-with-wearable-biosensors-during-high-performance-jet-flight
#14
G Merrill Rice, Dallas Snider, Jeffrey L Moore, J Timothy Lavan, Rich Folga, Thomas B VanBrunt
INTRODUCTION: Few studies have evaluated physiological responses to high acceleration forces during actual flight and to our knowledge no normative data has been acquired by technologies such as wearable biosensors during high performance jet aircraft operations. METHODS: In-flight physiological data from an FDA cleared portable triaxial accelerometer and bio-sensor were observed from five active duty F-18 pilots of the Naval Flight Demonstration Squadron (Blue Angels)...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28320892/sepiapterin-reductase-gene-disrupted-mice-suffer-from-hypertension-with-fluctuation-and-bradycardia
#15
Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose, Kazunao Kondo
(6R)-l-erythro-5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for monoamine and nitric oxide (NO) production. Sepiapterin reductase (SPR) catalyzes the final step in BH4 biosynthesis. We analyzed the cardiovascular function of adult Spr gene-disrupted (Spr(-/-)) mice for the first time. After weaning, Spr(-/-) mice suffered from hypertension with fluctuation and bradycardia, while the monoamine contents in these mice were less than 10% of those in the wild-type mice as a result of BH4 depletion...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28319954/comparison-of-initial-vasopressors-used-for-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#16
Bhaskar Roy, Louise D McCullough, Rajat Dhar, James Grady, Yu-Bo Wang, Robert J Brown
BACKGROUND: The main reason for morbidity after aneurysmal subarachnoid hemorrhage (aSAH) is delayed cerebral ischemia (DCI). The mainstay of medical therapy for treating DCI is induced hypertension with vasopressors to restore cerebral perfusion. Both phenylephrine (PE) and norepinephrine (NE) are commonly used for induced hypertension, but the impact of the initial choice of vasopressor on the efficacy, adverse effects, or outcome after hemodynamic therapy for DCI is unknown. METHODS: Sixty-three patients with aSAH between January 2012 and October 2014, who developed DCI (defined as new focal deficit or decline in Glasgow Coma Score) and in which PE (n = 45) or NE (n = 18) treatment was initiated were evaluated in this retrospective study...
March 21, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28316174/-efficacy-and-safety-analysis-of-ivabradine-hydrochloride-treatment-of-chinese-patients-with-chronic-heart-failure-subgroup-analysis-of-chinese-patients-in-the-shift-study
#17
D Y Hu, D J Huang, Z Y Yuan, R P Zhao, X W Yan, M H Wang
Objective: To evaluate the efficacy and safety of ivabradine for the treatment of Chinese patients with chronic heart failure based on the Chinese subgroup data of the systolic heart failure treatment with the I(f) inhibitor ivabradine trial (SHIFT). Method: A total of 6 558 stable outpatients who presented symptoms of heart failure, with a left ventricular ejection fraction (LVEF) ≤35%, sinus rhythms with a heart rate ≥70 bpm participated in the randomized, double-blind, placebo-controlled, international multicenter clinical study...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28315642/comparison-of-atipamezole-with-yohimbine-for-antagonism-of-xylazine-in-mice-anesthetized-with-ketamine-and-xylazine
#18
Christopher F Janssen, Pauline Maiello, M Jerry Wright, Kara B Kracinovsky, Joseph T Newsome
The α2 adrenergic agonist xylazine produces a sedative effect and is typically combined with ketamine and used for anesthesia or chemical restraint of laboratory mice. Xylazine's sedative effect-and its undesirable side effects of bradycardia, hypotension, and poor tissue perfusion-can be reversed by administration of α2 antagonists, such as atipamezole or yohimbine. Although atipamezole and yohimbine dosing guidelines are available for mice, no controlled comparison has been performed to guide the lab animal community in the selection of one over the other...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28304253/ventricular-parasystole-in-a-neonatal-rhesus-macaque-macaca-mulatta
#19
Dalis E Collins, Brandy L Dozier, Jeffrey J Stanton, Lois Ma Colgin, Rhonda MacAllister
A 6-d-old Indian-origin female rhesus macaque (Macaca mulatta) presented with bradycardia shortly after sedation with ketamine. No other cardiac abnormalities were apparent. Approximately 2 wk after the initial presentation, the macaque was again bradycardic and exhibited a regularly irregular arrhythmia on a prestudy examination. ECG, echocardiography, blood pressure measurement, SpO2 assessment, and a CBC analysis were performed. The echocardiogram and bloodwork were normal, but the infant was hypotensive at the time of echocardiogram...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28302610/selective-versus-standard-poststent-dilation-for-carotid-artery-disease-a-systematic-review-and-meta-analysis
#20
O Petr, W Brinjikji, M H Murad, B Glodny, G Lanzino
BACKROUND: The safety and efficacy of standard poststent angioplasty in patients undergoing carotid artery stent placement have not been well-established. PURPOSE: We conducted a systematic review of the literature to evaluate the safety and efficacy of carotid artery stent placement and analyzed outcomes of standard-versus-selective poststent angioplasty. DATA SOURCES: A systematic search of MEDLINE, EMBASE, Scopus, and the Web of Science was performed for studies published between January 2000 and January 2015...
March 16, 2017: AJNR. American Journal of Neuroradiology
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