Daniel T MacKeigan, Si-Yang Yu, Noa Chazot, Dachuan Zhang, Christopher J Khoury, Xi Lei, Preeti Bhoria, Chuanbin Shen, Pingguo Chen, Guangheng Zhu, Margaret L Rand, Scott Heximer, Heyu Ni
Platelets are small anucleate cells that play a key role in thrombosis and hemostasis. Our group previously identified apolipoprotein A-IV (apoA-IV) as an endogenous inhibitor of thrombosis by competitive blockade of the αIIbβ3 integrin on platelets. ApoA-IV inhibition of platelets was dependent on the N-terminal D5/D13 residues, and enhanced with absence of the C-terminus, suggesting it sterically hinders its N-terminal platelet binding site. The C-terminus is also the site of common apoA-IV polymorphisms apoA-IV-1a (T347S) and apoA-IV-2 (Q360H)...
April 16, 2024: Biochemical and Biophysical Research Communications