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https://www.readbyqxmd.com/read/29679294/gender-differences-in-home-based-cardiac-rehabilitation-of-post-percutaneous-coronary-intervention-patients
#1
Yong Hwan Kim, Wi-Young So
Cardiac rehabilitation (CR) is a structured program for the prevention of secondary cardiovascular disease (CVD) and related diseases, such as hypertension, diabetes, and obesity. This study aimed to investigate whether there are gender differences after 9 months of home-based cardiac rehabilitation program in post-percutaneous coronary intervention patients. A total of 114 (58.29 ± 10.33 years) men and 30 (60.90 ± 9.32 years) women were enrolled in the CR program. The program included three visits: initial, 4th month (follow-up), and 9th month (final) visits at a CR center...
April 20, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29678337/relation-of-coronary-culprit-lesion-morphology-determined-by-optical-coherence-tomography-and-cardiac-outcomes-to-serum-uric-acid-levels-in-patients-with-acute-coronary-syndrome
#2
Nobuaki Kobayashi, Noritake Hata, Masafumi Tsurumi, Yusaku Shibata, Hirotake Okazaki, Akihiro Shirakabe, Masamichi Takano, Yoshihiko Seino, Wataru Shimizu
The aims of the present study were to elucidate features of culprit lesion plaque morphology using optical coherence tomography (OCT) in relation to elevated serum uric acid (sUA) levels and to clarify the impact of sUA levels on adverse clinical outcomes in patients with acute coronary syndrome (ACS). Clinical data and outcomes were compared between ACS patients with sUA ≥6 mg/dl (high-sUA; n = 506) and sUA <6.0 mg/dl (low-sUA; n = 608). Angiography and OCT findings were analyzed in patients with preintervention OCT and compared between groups of high-sUA (n = 206) and low-sUA (n = 273)...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29678058/building-a-knowledge-based-tool-for-auto-assessing-the-cardiovascular-risk
#3
Adrien Ugon, Amel Imene Hadj Bouzid, Marie-Christine Jaulent, Madeleine Favre, Catherine Duclos, Emmanuel Jobez, Hector Falcoff, Jean-Baptiste Lamy, Rosy Tsopra
The prevention of cardiovascular diseases needs first to quantify the cardiovascular risk. To estimate this risk, French national health authorities provided clinical practice guidelines extending the existing European SCORE, which doesn't include all the cardiovascular risk factors (e.g. diabetes). Hence, French national clinical practice guidelines to quantify the cardiovascular risk is able to deal with more clinical situations than the SCORE. The goal of this paper is to formalize knowledge extracted from these guidelines and implement the rules so that they can be used into an auto-assessing tool of cardiovascular risk...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677687/endothelial-dysfunction-as-a-long-term-effect-of-late-onset-hypertensive-pregnancy-disorders-high-bmi-is-key
#4
L J Alma, C J M De Groot, R X De Menezes, W Hermes, P L Hordijk, I Kovačević
OBJECTIVE: Hypertensive disorders during pregnancy increase cardiovascular risk later in life by 2 to 9-fold. Endothelial activation is one of the underlying mechanisms of cardiovascular risk. Therefore, we decided to investigate endothelial activation in primiparous women, 2.5 years after a hypertensive pregnancy disorder. STUDY DESIGN: Plasma samples were taken from women 2.5 years after gestational hypertension (GH) or late onset preeclampsia (cases) and from women 2...
April 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29677051/electrocardiographic-predictors-of-atrial-fibrillation-in-nonhypertensive-and-hypertensive-individuals
#5
Arttu O Lehtonen, Ville L Langén, Kimmo Porthan, Mika Kähönen, Markku S Nieminen, Antti M Jula, Teemu J Niiranen
OBJECTIVE: The aim of this study was to compare the predictive value of ECG abnormalities for atrial fibrillation in nonhypertensive versus hypertensive individuals. METHODS: We recorded ECG and measured conventional cardiovascular risk factors in a nationwide population-based sample of 5813 Finns. We divided the participants into nonhypertensive (n = 3148) and hypertensive (n = 2665) individuals and followed the participants for incident atrial fibrillation events...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29676968/effects-of-daily-intake-of-calcium-and-vitamin-d-enriched-milk-in-healthy-postmenopausal-women-a-randomized-controlled-double-blind-nutritional-study
#6
Rebeca Reyes-Garcia, Nicolas Mendoza, Santiago Palacios, Nancy Salas, Miguel Quesada-Charneco, Antonia Garcia-Martin, Juristo Fonolla, Federico Lara-Villoslada, Manuel Muñoz-Torres
OBJECTIVE: To determine the effect of the daily intake of calcium and vitamin D-enriched milk (with or without fructooligosaccharides [FOS]) on vitamin D, bone metabolism, and cardiovascular risk factors. MATERIALS AND METHODS: Two-year randomized controlled study, including 500 healthy postmenopausal women, assigned to 500 mL/day of skimmed milk to one of three groups: Low-dose (L): (120 mg/100 mL calcium, vitamin D3 30 UI/100 mL), group A: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL), and group B: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL) and FOS (5 g/L)...
April 20, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29676517/impact-of-changes-in-inflammation-on-estimated-10-year-cardiovascular-risk-in-rheumatoid-arthritis
#7
Zhi Yu, Nicole Yang, Brendan M Everett, Michelle Frits, Christine Iannaccone, Jonathan Coblyn, Michael Weinblatt, Nancy Shadick, Daniel H Solomon, Katherine P Liao
BACKGROUND: Validated cardiovascular (CV) risk estimates were developed in populations with relatively stable inflammatory levels. In rheumatoid arthritis (RA), patients routinely experience significant changes in inflammation. We tested whether changes in inflammation impact estimated CV risk as measured using validated population-based risk calculators. METHODS: We studied participants in a prospective RA cohort. We included participants who experienced a decrease (CRP decrease group) or increase (CRP increase group) of ≥10mg/L in C-reactive protein (CRP) at 2 consecutive time points, 1 year apart...
April 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29676178/afm-as-a-tool-to-evaluate-the-risk-for-cardiovascular-diseases-in-patients
#8
Ana Filipa Guedes, Luís Sargento, José Braz-Nogueira, Nuno Lousada, Carlos Moreira, Filomena A Carvalho, Nuno C Santos
Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Fibrinogen-erythrocyte and erythrocyte-erythrocyte adhesion measurements were conducted by atomic force microscopy (AFM)-based force spectroscopy...
2018: Annals of Medicine
https://www.readbyqxmd.com/read/29675621/myocardial-function-in-primary-antiphospholipid-syndrome-using-speckle-tracking-echocardiography
#9
Gabriela Medina, Eduardo Gómez-Bañuelos, Erick Calderón-Aranda, María Pilar Cruz-Domínguez, Olga Vera-Lastra, Luis J Jara
Antiphospholipid syndrome (APS) patients have high cardiovascular risk. Speckle-tracking echocardiography (STE) detects myocardial function. To evaluate the myocardial function in primary APS (PAPS) patients using two-dimensional echocardiography (2-D) obtaining values of left ventricle global longitudinal strain (GLS) by STE. Patients with PAPS, > 16 years, both genders, without signs and symptoms of heart disease were recruited and matched with healthy controls by age and gender. Demographic, clinical data, and cardiovascular risk factors were recorded...
April 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29675613/the-role-of-central-blood-pressure-monitoring-in-the-management-of-hypertension
#10
REVIEW
Adrian Ochoa, Gabriel Patarroyo-Aponte, Mahboob Rahman
PURPOSE OF REVIEW: Central blood pressure is a novel predictor of cardiovascular risk that can be measured in the clinical setting using currently available technology. This paper will review current available methods of central blood pressure monitoring as well as its impact in cardiac and renal disease. RECENT FINDINGS: Both aortic and carotid systolic blood pressure are independently associated with cardiovascular mortality and serious cardiac events. Furthermore, studies show that systolic aortic blood pressure has been shown to be superior predictor of cardiovascular as compared to brachial blood pressure...
April 19, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29675611/ponatinib-as-second-line-treatment-in-chronic-phase-chronic-myeloid-leukemia-patients-in-real-life-practice
#11
Massimo Breccia, Elisabetta Abruzzese, Fausto Castagnetti, Massimiliano Bonifacio, Domenica Gangemi, Federica Sorà, Alessandra Iurlo, Luigiana Luciano, Antonella Gozzini, Massimo Gentile, Monica Bocchia, Debora Luzi, Alessandro Maggi, Nicola Sgherza, Alessandro Isidori, Monica Crugnola, Patrizia Pregno, Anna Rita Scortechini, Isabella Capodanno, Michele Pizzuti, Robin Foà
Scarce information is available on the use of ponatinib as second-line treatment in chronic phase chronic myeloid leukemia (CP-CML) patients resistant and/or intolerant to prior tyrosine kinase inhibitor (TKI) therapy. We collected data from 29 CML patients, with a median age of 54 years (range 32-72). Eleven patients had received dasatinib, 15 patients received nilotinib, and 3 patients received imatinib as first-line treatment. Forty-five percent of patients started ponatinib for secondary resistance, 38% for primary resistance, 7% for severe intolerance associated to a molecular warning, 7% due to the presence of a T315I mutation, and 3% for severe intolerance...
April 19, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29675043/cardiovascular-risk-factors-after-childhood-cancer-treatment-are-independent-of-the-fto-gene-polymorphism
#12
Małgorzata Sawicka-Żukowska, Maryna Krawczuk-Rybak, Paweł Bernatowicz, Katarzyna Muszyńska-Rosłan, Jerzy Konstantynowicz, Włodzimierz Łuczyński
The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer ( N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic ( FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as many as 42.5%. At least one abnormality in lipid metabolism was observed in 35...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29675020/systemic-inflammation-and-cardiovascular-comorbidity-in-psoriasis-patients-causes-and-consequences
#13
REVIEW
Wolf-Henning Boehncke
Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, comprising inflammation, hyperproliferation, and angioneogenesis, intrigues numerous scientific disciplines, namely, immunology. From a clinical perspective, the severity of psoriasis is highlighted by its increased mortality, with cardiovascular diseases contributing the highest excess risk...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674798/switching-of-antihypertensive-drugs-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-investigation
#14
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Venkaiah Kodali, Dinesh Kumar Bharatraj
OBJECTIVE: Switching of antihypertensive drugs is attributed to uncontrolled blood pressure (BP) which imposes a great burden on health economics. But again, switching leads to accomplishment of the goal BP, thereby improving the health status. Such studies are well documented in developed nations but rarely reported in developing countries, especially in India. Therefore, the aim of this study was to evaluate various factors associated with switching of antihypertensive drugs. METHODS: A cross-sectional retrospective investigation was performed using a standardized schedule adapting the World Health Organization indicators for drug utilization in a tertiary care government hospital, Hyderabad, India...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674687/celecoxib-exerts-protective-effects-in-the-vascular-endothelium-via-cox-2-independent-activation-of-ampk-creb-nrf2-signalling
#15
Fahad Al-Rashed, Damien Calay, Marie Lang, Clare C Thornton, Andrea Bauer, Allan Kiprianos, Dorian O Haskard, Anusha Seneviratne, Joseph J Boyle, Alex H Schönthal, Caroline P Wheeler-Jones, Justin C Mason
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674187/lower-maternal-serum-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-levels-in-early-preeclampsia-a-retrospective-study
#16
Danila Morano, Alessandro Rolfo, Veronica Tisato, Antonio Farina, Erika Rimondi, Gennaro Scutiero, Pantaleo Greco, Gloria Bonaccorsi, Tullia Todros
OBJECTIVE: To determine whether maternal serum concentrations of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a cytokine with anti-inflammatory activity, also involved in cardiovascular morbidity, differ between women with early preeclampsia (<34 weeks) and those with uncomplicated pregnancies. STUDY DESIGN: This nested case control study included 40 women carrying a single fetus with an uncomplicated pregnancy and 20 women with early preeclampsia (<34 weeks)...
February 7, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673963/no-difference-in-cardiovascular-risk-of-tocilizumab-versus-abatacept-for-rheumatoid-arthritis-a-multi-database-cohort-study
#17
Seoyoung C Kim, Daniel H Solomon, James R Rogers, Sara Gale, Micki Klearman, Khaled Sarsour, Sebastian Schneeweiss
OBJECTIVES: While tocilizumab may increase serum lipid levels, recent studies do not suggest a link between tocilizumab use and clinical cardiovascular risk in patients with rheumatoid arthritis (RA). METHODS: To compare cardiovascular safety of tocilizumab with abatacept, we conducted a cohort study using data from Medicare (2010-2013), IMS PharMetrics (2011-2014) and MarketScan (2011-6/2015). RA patients aged ≥18 years who newly started tocilizumab or abatacept entered the cohort on the day of their first use of tocilizumab or abatacept after a continuous enrollment period for ≥365 days...
March 22, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29673926/the-investigations-of-genetic-determinants-of-the-metabolic-syndrome
#18
REVIEW
Behdokht Fathi Dizaji
Metabolic syndrome is the aggregation of cardiovascular risk factors that increases the risk of type 2 diabetes and cardiovascular diseases. Family and twin studies, heritability spectrum for its components and different prevalence among ethnicities, have provided genetic susceptibility to the metabolic syndrome. The investigations of genetic base for the disorder have recognized numerous chromosomes, various DNA polymorphisms in candidate genes and many gene variants, that are associated with metabolic syndrome as an entity or its traits, which mostly are related to lipid metabolism...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29673465/effect-of-aspirin-coadministration-on-the-safety-of-celecoxib-naproxen-or-ibuprofen
#19
Grant W Reed, Mouin S Abdallah, Mingyuan Shao, Kathy Wolski, Lisa Wisniewski, Neville Yeomans, Thomas F Lüscher, Jeffrey S Borer, David Y Graham, M Elaine Husni, Daniel H Solomon, Peter Libby, Venu Menon, A Michael Lincoff, Steven E Nissen
BACKGROUND: The safety of nonsteroidal anti-inflammatory drug (NSAID) and aspirin coadministration is uncertain. OBJECTIVES: The aim of this study was to compare the safety of combining NSAIDs with low-dose aspirin. METHODS: This analysis of the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen) trial included 23,953 patients with osteoarthritis or rheumatoid arthritis at increased cardiovascular risk randomized to celecoxib, ibuprofen, or naproxen...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29673349/severe-dyslipidemia-and-concomitant-risk-factors-in-the-middle-aged-lithuanian-adults-a-cross-sectional-cohort-study
#20
Sandra Kutkienė, Žaneta Petrulionienė, Aleksandras Laucevičius, Marija Petrylaitė, Diana Maskeliūnaitė, Roma Puronaitė, Milda Kovaitė, Irma Kalibaitaitė, Egidija Rinkūnienė, Vilma Dženkevičiūtė, Vytautas Kasiulevičius
BACKGROUND: Dyslipidemia is highly prevalent and is one of the major risk factors for cardiovascular disease in Lithuania. The purpose of this study was to determine the prevalence of severe dyslipidemia in Lithuanian middle aged primary prevention population and to investigate cardiovascular risk profile. METHODS: The group of 83,376 people were examined in the Lithuanian High Cardiovascular Risk primary prevention program (LitHiR), during 2009-2015 years. This study recruited middle aged men and women without overt cardiovascular disease...
April 19, 2018: Lipids in Health and Disease
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