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"Cardiovascular risk"

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https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#1
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#2
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29040598/effect-of-metformin-on-vascular-function-in-children-with-type-1-diabetes-a-12-month-randomized-controlled-trial
#3
Jemma J A Anderson, Jennifer J Couper, Lynne C Giles, Catherine E Leggett, Roger Gent, Brian Coppin, Alexia S Peña
Context: Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective: To evaluate the effect of metformin on vascular function in type 1 diabetes children. Design: 12 month double blind, randomized, placebo-controlled trial. Setting: Tertiary pediatric diabetes clinic. Participants: 90 type 1 diabetes children(8-18 years), above 50th percentile body mass index (BMI)...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29040528/improving-cardiovascular-risk-prediction-a-tale-of-sisyphus
#4
Marc L De Buyzere, Thierry C Gillebert
No abstract text is available yet for this article.
October 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29036837/simvastatin-as-a-potential-disease-modifying-therapy-for-patients-with-parkinson-s-disease-rationale-for%C3%A2-clinical-trial-and-current-progress
#5
Camille B Carroll, Richard K H Wyse
Many now believe the holy grail for the next stage of therapeutic advance surrounds the development of disease-modifying approaches aimed at intercepting the year-on-year neurodegenerative decline experienced by most patients with Parkinson's disease (PD). Based on recommendations of an international committee of experts who are currently bringing multiple, potentially disease-modifying, PD therapeutics into long-term neuroprotective PD trials, a clinical trial involving 198 patients is underway to determine whether Simvastatin provides protection against chronic neurodegeneration...
October 13, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29036778/electronic-clinical-decision-support-tool-for-the-evaluation-of-cardiovascular-risk-in-general-practice-a-pilot-study
#6
Jason Chiang, John Furler, Douglas Boyle, Malcolm Clark, Jo-Anne Manski-Nankervis
BACKGROUND: Cardiovascular disease (CVD) is a major cause of death in Australia. Electronic medical record (EMR)-based clinical decision support (CDS) tools have the potential to support absolute CVD risk (ACVDR) evaluation and management. The objective of this study was to test the acceptability and feasibility of the Treat to Target CVD (T3CVD), an EMR-based CDS tool, for the evaluation of ACVDR in general practice. METHODS: Five general practitioners (GPs) piloted the T3CVD tool in their clinic...
October 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29036280/invited-commentary-sex-race-differences-in-diabetes-and-cardiovascular-disease-achieving-the-promise-of-sex-and-race-subgroup-analyses-in-epidemiologic-research
#7
Nathalie Moise, Alain G Bertoni
Diabetes confers a higher risk of cardiovascular disease in women than men. The reasons for these sex differences, such as poorer cardiovascular risk factor profiles, have received considerable attention. However, a recent report on sex-diabetes interactions on cardiovascular disease identified that few if any prior studies have confirmed these sex-differences in blacks, despite known diabetes-related disparities. In the current issue of the Journal, George et al. (2017) find marginally significant multiplicative sex by diabetes interactions in blacks but not whites after adjustments for traditional and behavioral risk factors, competing risk and change in diabetes status over time...
October 4, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29035971/dietary-patterns-and-cognition-in-older-persons
#8
Angela M Abbatecola, Marcello Russo, Michelangela Barbieri
PURPOSE OF REVIEW: The current article reviews recently published evidence of the important role that specific dietary patterns may hold on preventing cognitive impairment and dementia over aging. RECENT FINDINGS: Specific dietary patterns attributed to targeting cardiovascular risk factors may protect against the development of mild cognitive impairment (MCI) and dementia, especially Alzheimer's disease. Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons...
October 14, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29035944/association-between-common-carotid-artery-diameter-and-target-organ-damage-in-essential-hypertension
#9
Yan Yang, Yan Wang, Jianzhong Xu, Pingjin Gao
OBJECTIVES: To investigate the relationship between common carotid artery diameter (CCA-D) and target organ damage (TOD) in essential hypertension. METHODS AND RESULTS: A total of 200 essential hypertensive patients were enrolled (mean age 62.5 ± 9.5, men 59.0%) and were classified into two groups by the height-adjusted mean median of CCA-D: patients with CCA-D/height less than 3.905 mm/m (n = 100, 50%) and patients with CCA-D/height more than 3.905 mm/m (n = 100, 50%)...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035943/metabolic-syndrome-and-subclinical-carotid-damage-a-meta-analysis-from-population-based-studies
#10
Cesare Cuspidi, Carla Sala, Fabio Provenzano, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: Metabolic syndrome (MetS) is a phenotype of growing prevalence in the general population. Information on the association between MetS and vascular damage in this setting is only based on data provided by single reports. We performed a meta-analysis of population-based studies aimed to assess the association of MetS with carotid atherosclerosis. DESIGN: Studies were identified by the following search terms: 'metabolic syndrome', 'general population,' 'carotid intima-media thickness' (IMT), 'carotid atherosclerosis,' 'carotid damage,' 'ultrasonography...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035940/perspectives-on-hypertension-s-prevalence-treatment-and-control-in-a-high-cardiovascular-risk-east-european-country-data-from-the-sephar-iii-survey
#11
Maria Dorobantu, Oana-Florentina Tautu, Doina Dimulescu, Crina Sinescu, Paul Gusbeth-Tatomir, Catalina Arsenescu-Gerogescu, Florin Mitu, Daniel Lighezan, Calin Pop, Katalin Babes, Alina Giuca, Ileana Branza, Mihaela Udrescu, Valeria Herdea, Roxana Darabont
OBJECTIVES: To estimate the trend in arterial hypertension's prevalence, awareness, treatment, and control in Romania, starting from the latest national survey Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in Romania III that has a crucial importance for the development of prevention strategies at national level. METHODS: A representative sample of 1970 Romanian adults (mean age 48.38 years, age range 18-80 years, 52.5% women, 72...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035939/predictors-for-the-development-of-microalbuminuria-and-interaction-with-renal-function
#12
Christos Chatzikyrkou, Jan Menne, Joseph Izzo, Giancarlo Viberti, Ton Rabelink, Luis M Ruilope, Christian Rump, Peter R Mertens, Hermann Haller
AIM: It is important to know which factors predict the development of microalbuminuria in patients with diabetes mellitus type II. MATERIAL: Data from the Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study were used to identify predictors for the new onset of microalbuminuria. Furthermore, the interaction of baseline albuminuria and baseline estimated glomerular filtration rate (eGFR) and the effects of treatment with olmesartan were investigated...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29034576/substantial-variability-across-individuals-in-the-vascular-and-nutrigenomic-response-to-an-acute-intake-of-curcumin-a-randomised-controlled-trial
#13
Nicolas Barber-Chamoux, Dragan Milenkovic, Marie-Anne Verny, Véronique Habauzit, Bruno Pereira, Céline Lambert, Damien Richard, Céline Boby, Andrzej Mazur, Jean René Lusson, Claude Dubray, Christine Morand
SCOPE: Curcumin exerts biological activities of interest in cardiovascular prevention. However, its vascular protective effect is still poorly investigated in humans. The present study aims to assess vasculat effect of an acute intake of curcumin and its nutrigenomic impact in circulating immune cells. METHODS AND RESULTS: In a randomised, double-blind, crossover design, eighteen healthy smokers consumed a placebo or a 5-gram of curcumin. Before and two hours after the intake, vascular function measurements were performed by using flow-mediated dilation (FMD)...
October 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29034321/refractory-versus-resistant-hypertension-novel-distinctive-phenotypes
#14
Tanja Dudenbostel, Mohammed Siddiqui, Nitin Gharpure, David A Calhoun
Resistant hypertension (RHTN) is relatively common with an estimated prevalence of 10-20% of treated hypertensive patients. It is defined as blood pressure (BP) >140/90 mmHg treated with ≥3 antihypertensive medications, including a diuretic, if tolerated. Refractory hypertension is a novel phenotype of severe antihypertensive treatment failure. The proposed definition for refractory hypertension, i.e. BP >140/90 mmHg with use of ≥5 different antihypertensive medications, including a diuretic and a mineralocorticoid receptor antagonist (MRA) has been applied inconsistently...
September 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/29034255/perioperative-management-of-elderly-patients-with-gastrointestinal-malignancies-the-contribution-of-anesthesia
#15
REVIEW
Rudolf Mörgeli, Kathrin Scholtz, Johannes Kurth, Sascha Treskatsch, Bruno Neuner, Susanne Koch, Lutz Kaufner, Claudia Spies
INTRODUCTION: Elderly patients suffering from gastrointestinal malignancies are particularly prone to perioperative complications. Elderly patients often present with reduced physiological reserves, and comorbidities can limit treatment options and promote complications. Surgeons and anesthesiologists must be aware of strategies required to deal with this vulnerable subgroup. METHODS: We provide a brief review of current and emerging perioperative strategies for the treatment of elderly patients with gastrointestinal malignancies and frequent comorbidities...
August 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29033193/cardiovascular-risk-assessment-in-elderly-adults-using-score-op-model-in-a-latin-american-population-the-experience-from-ecuador
#16
Ivan Sisa
INTRODUCTION AND OBJECTIVE: Cardiovascular disease (CVD) mortality is predicted to increase in Latin America countries due to their rapidly aging population. However, there is very little information about CVD risk assessment as a primary preventive measure in this high-risk population. MATERIAL AND METHODS: We predicted the national risk of developing CVD in Ecuadorian elderly population using the Systematic COronary Risk Evaluation in Older Persons (SCORE OP) High and Low models by risk categories/CVD risk region in 2009...
October 12, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29032954/coronary-flow-reserve-is-predictive-of-the-risk-of-cardiovascular-death-regardless-of-chronic-kidney-disease-stage
#17
David M Charytan, Hicham Skali, Nishant R Shah, Vikas Veeranna, Michael K Cheezum, Viviany R Taqueti, Takashi Kato, Courtney R Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
Microvascular rarefaction is found in experimental uremia, but data from patients with chronic kidney disease (CKD) are limited. We therefore quantified absolute myocardial blood flow and coronary flow reserve (the ratio of peak to resting flow) from myocardial perfusion positron emission tomography scans at a single institution. Individuals were classified into standard CKD categories based on the estimated glomerular filtration rate. Associations of coronary flow reserve with CKD stage and cardiovascular mortality were analyzed in models adjusted for cardiovascular risk factors...
October 13, 2017: Kidney International
https://www.readbyqxmd.com/read/29032396/assessing-adherence-to-antihypertensive-therapy-in-primary-health-care-in-namibia-findings-and-implications
#18
M M Nashilongo, B Singu, F Kalemeera, M Mubita, E Naikaku, A Baker, A Ferrario, B Godman, L Achieng, D Kibuule
INTRODUCTION: Namibia has the highest burden and incidence of hypertension in sub-Sahara Africa. Though non-adherence to antihypertensive therapy is an important cardiovascular risk factor, little is known about potential ways to improve adherence in Namibia following universal access. The objective of this study is to validate the Hill-Bone compliance scale and determine the level and predictors of adherence to antihypertensive treatment in primary health care settings in sub-urban townships of Windhoek, Namibia...
October 14, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29031803/the-burden-and-correlates-of-hypertension-among-chinese-rural-population-in-han-uygur-and-kazak-%C3%A2-a%C3%A2-cross-sectional-study
#19
Yong-Tao Wang, Dilare Adi, Zi-Xiang Yu, Yi-Tong Ma, Yi-Ning Yang, Xiao-Mei Li, Xiang Ma, Fen Liu, Bang-Dang Chen
The present study was conducted to investigate the prevalence, awareness, treatment, control, and associated risk factors of hypertension among rural population in Xinjiang Province in Northwest China. The Cardiovascular Risk Survey study was conducted on a representative sample of the Northwest China adult population. A four-stage stratified cluster random sampling scheme was adopted to recruit representative samples. The data were collected by trained staff. Multivariable logistic regression models were used to identify the associated risk factors...
September 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29031563/gender-specific-association-of-desacylated-ghrelin-with-subclinical-atherosclerosis-in-the-metabolic-syndrome
#20
Michela Zanetti, Gianluca Gortan Cappellari, Annamaria Semolic, Ismet Burekovic, Maurizio Fonda, Luigi Cattin, Rocco Barazzoni
OBJECTIVE: Ghrelin, a gastric hormone with pleiotropic effects modulates vascular function and may influence atherosclerosis. Plasma ghrelin is reduced in the metabolic syndrome (MS), which is also characterized by early atherosclerosis. Ghrelin circulates in acylated (AG) and desacylated (DAG) forms. Their relative impact and that of gender on subclinical atherosclerosis in MS is unknown. AIM OF THE STUDY: To investigate potential associations of total, AG and DAG with carotid atherosclerosis and with gender in the MS...
October 11, 2017: Archives of Medical Research
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