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"Cardiovascular risk"

S G Kozlov, L Sh Khamchieva, O A Pogorelova, M I Tripoten', T V Balakhonova
The study was aimed at assessing the dynamics of asymptomatic atherosclerosis of carotid arteries (CA) depending upon the achieved level of low-density lipoprotein cholesterol (LDLC) in patients with moderate total risk by the SCORE scale. We followed up a total of eighty-two 40-to-65-year-old patients with the LDLC level above 2.6 mmol/l, being at moderate total risk by the SCORE scale and having symptom-free atherosclerosis of the extracranial portion of brachiocephalic arteries (up to 50% narrowing of their lumen) as diagnosed by duplex scanning...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Camilla Ribeiro Lima de Farias, Carla Campos Muniz Medeiros, Diogo Rodrigues Souza, Ivelise Fhrideraid Alves Furtado da Costa, Mônica Oliveira da Silva Simões, Danielle Franklin de Carvalho
OBJECTIVE: to verify persistence of metabolic syndrome (MetS) and components in overweight children and adolescents, as well as its relation to socioeconomic and demographic characteristics and to the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score. METHOD: a two-point longitudinal study: at enrollment and after a 24-month interval, with 133 individuals ages from two to 18 years. The demographic anthropomorphic and blood variables were evaluated...
May 2018: Revista Brasileira de Enfermagem
Bingshu Wu, Hongzhi Zheng, Jianqiu Gu, Yan Guo, Yixuan Liu, Yingfang Wang, Feng Chen, Aolin Yang, Jiabei Wang, Hailong Wang, Ying Liu, Difei Wang
INTRODUCTION: In this meta-analysis, we aimed to determine the effects of SGLT-2i in addition to insulin therapy on cardiovascular risk factors in type 2 diabetic patients MATERIALS AND METHODS: RCTs were identified by searching the PubMed, Embase, and Cochrane Library databases published before September 2017. Intervention group received SGLT-2i as add-on to insulin therapy, controlled with those received placebos in addition to insulin. We assessed pooled data, including WMDs and 95% CIs, using a random-effects model RESULTS: Ten RCTs (n =5159) were eligible...
June 19, 2018: Journal of Diabetes Investigation
Thais Coutinho, Olabimpe Lamai, Kara Nerenberg
PURPOSE OF THE REVIEW: Cardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk. RECENT FINDINGS: Robust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to women with normotensive pregnancies...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
Guy Witberg, Jalal Bathish, Tamir Bental, Dorit Leshem-Lev, Abid Assali, Ran Kornowski, Eli Lev
To assess the effect of cessation of dual antiplatelet therapy (DAPT) regimens containing 2nd generation P2 Y12 inhibitors on platelet reactivity, in patients who completed 12 months of DAPT following an acute myocardial infarction. Clinical data has shown an increased cardiovascular risk in the 90 days following cessation of DAPT. One possible explanation is a transient platelet hyper-reactivity after cessation of treatment. Data from patients treated with 2nd generation P2 Y12 inhibitors is scarce. Patients who completed 12 month DAPT with prasugrel/ticagrelor underwent serial assessment of platelet reactivity (on DAPT and 1, 4 and 12 weeks post cessation)...
June 19, 2018: Journal of Thrombosis and Thrombolysis
Matthias Heinig
Genetic variants at hundreds of loci associated with cardiovascular phenotypes have been identified by genome wide association studies. Most of these variants are located in intronic or intergenic regions rendering the functional and mechanistic follow up difficult. These non-protein-coding regions harbor regulatory sequences. Thus the study of genetic variants associated with transcription-so called expression quantitative trait loci-has emerged as a promising approach to identify regulatory sequence variants...
2018: Frontiers in Cardiovascular Medicine
Maurizio Benucci, Francesca Bandinelli, Arianna Damiani, Francesca Li Gobbi, Maria Infantino, Valentina Grossi, Mariangela Manfredi
Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease. Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of prednisone 5.2±1.2 mg/day and Methotrexate 11.5±2.1 mg at baseline (T0) and after 12 months (T1) of treatment with Abatacept 125 mg/week...
2018: Journal of Inflammation Research
Claudia Szlejf, Claudia K Suemoto, Itamar S Santos, Andre R Brunoni, Maria Angélica Nunes, Maria Carmen Viana, Sandhi Maria Barreto, Paulo A Lotufo, Isabela M Benseñor
BACKGROUND: Common psychiatric symptoms may hinder achieving ideal cardiovascular health (ICH). We aimed to investigate the association between the ICH score and psychiatric disorders in Brazilian adults. METHODS: In this cross-sectional analysis, 13,743 participants free of cardiovascular disease from the ELSA-Brasil study were assessed using the American Heart Association ICH score. Cardiovascular health was classified as poor (0-2 ideal metrics), intermediate (3-4 ideal metrics), and optimal (5-7 ideal metrics)...
June 12, 2018: International Journal of Cardiology
I Made Ady Wirawan, Robin F Griffiths, Peter D Larsen
BACKGROUND: This study aims to examine which marker or testing protocols have been suggested for cardiovascular disease (CVD) risk assessment in asymptomatic populations, at which CVD risk level, and how this can be implemented for CVD risk assessment in pilot populations. METHODS: A systematic search was performed using Systematic Reviews Subset on PubMed; the OvidSP interface, including all EBM reviews and EMBASE databases; and the G-I-N International Guideline Library...
July 1, 2018: Aerospace Medicine and Human Performance
Jung Ran Choi, Sang Baek Koh, Eunhee Choi
BACKGROUND: Several anthropometric indices such as body mass index (BMI) and waist circumference (WC) have been examined as indicators of cardiovascular diseases, in both adults and children. However, the waist-to-height ratio (WHtR) is considered a better predictor for the detection of cardiovascular risk factors, than BMI. We investigated the association between the WHtR and incident hypertension. METHODS: A total of 1718 participants, aged 39-72 years, were recruited in this longitudinal study...
June 19, 2018: BMC Public Health
Tessa A Kouwenhoven-Pasmooij, Suzan J W Robroek, Roderik A Kraaijenhagen, Pieter H Helmhout, Daan Nieboer, Alex Burdorf, M G Myriam Hunink
BACKGROUND: Web-based lifestyle interventions at the workplace have the potential to promote health and work productivity. However, the sustainability of effects is often small, which could be enhanced by adding face-to-face contacts, so-called 'blended care'. Therefore, this study evaluates the effects of a blended workplace health promotion intervention on health and work outcomes among employees with increased cardiovascular risk. METHODS: In this multicentre cluster-randomised controlled trial (PerfectFit), 491 workers in 18 work units from military, police, and a hospital with increased cardiovascular risk were randomised into two intervention groups...
June 19, 2018: BMC Public Health
Hjørdis Thorsteinsdottir, Trond H Diseth, Anine Lie, Trine Tangeraas, Iren Matthews, Anders Åsberg, Anna Bjerre
This study estimates the effects on peak oxygen uptake (VO2 peak ), QoL, and mental health after the introduction of an adjusted post-transplant follow-up program, that is, early physiotherapy and focus on the importance of physical activity. VO2 peak was measured by a treadmill exercise test in 20 renal-transplanted children on the adjusted post-transplant follow-up and compared with a group of 22 patients investigated in a previously, before the implementation of our new follow-up routines. PedsQL and The Strengths and Difficulties Questionnaire (SDQ) were used to assess QoL and mental health in 45 patients on the new as compared to 32 patients on the previous follow-up strategy...
June 19, 2018: Pediatric Transplantation
K K Andersen, T S Olsen
OBJECTIVES: Most studies show that marriage conveys a survival advantage. Whether this is valid also for stroke patients is unclear. Results of studies have been inconsistent and conflicting. MATERIAL & METHODS: We studied 1-week and 1-month stroke case-fatality in relation to marital status (married, unmarried, divorced, and widowed) in all patients admitted to hospital for incident stroke in Denmark during 2003-2012. We used information from Danish registries on stroke merged to information on age, sex, marital status, stroke severity, stroke subtype, socioeconomic status, cardiovascular risk profile, and causes of death...
June 19, 2018: Acta Neurologica Scandinavica
Irene Pusceddu, Marcus Kleber, Graciela Delgado, Wolfgang Herrmann, Winfried März, Markus Herrmann
INTRODUCTION: Short telomeres have been associated with adverse lifestyle factors, cardiovascular risk factors and age-related diseases, including cardiovascular disease (CVD), myocardial infarction, atherosclerosis, hypertension, diabetes, and also with mortality. However, previous studies report conflicting results. OBJECTIVES: The aim of the present study has been to investigate the involvement of telomere length in all-cause and CVD mortality in subjects hospitalized for diagnostic coronary angiography of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study...
2018: PloS One
Elodie Gautier-Veyret, Magnus Bäck, Claire Arnaud, Elise Belaïdi, Renaud Tamisier, Patrick Lévy, Nathalie Arnol, Marion Perrin, Jean-Louis Pépin, Françoise Stanke-Labesque
AIMS: Obstructive sleep apnea (OSA) characterized by nocturnal intermittent hypoxia (IH) is associated with atherosclerosis and cysteinyl-leukotrienes (CysLT) pathway activation. We aimed to identify the determinants of CysLT pathway activation and the role of CysLT in OSA-related atherosclerosis. METHODS AND RESULTS: Determinants of the urinary excretion of LTE4 (U-LTE4 ) including history of cardiovascular events, polysomnographic and biological parameters were studied in a cohort of 170 OSA patients and 29 controls, and in a subgroup of OSA patients free of cardiovascular event (n = 136)...
June 16, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Speranza Rubattu, Maria Cotugno, Maurizio Forte, Rosita Stanzione, Franca Bianchi, Michele Madonna, Simona Marchitti, Massimo Volpe
OBJECTIVES: The combination of AT1 blocker/neutroendopeptidase neprilysin inhibition (ARNi) represents an interesting approach to reduce cardiovascular risk in hypertension. We assessed the efficacy of ARNi, compared with angiotensin II type 1 receptor blockade alone, on blood pressure (BP) and on protection from target organ damage development in the stroke-prone spontaneously hypertensive rat (SHRSP). METHODS: In high-salt fed SHRSP, we assessed plasma and tissue natriuretic peptides, urinary volume, BP and body weight over a short-term treatment (6 weeks) with either ARNi (sacubitril/valsartan 68 mg/kg per day) or valsartan (30 mg/kg per day), protection from stroke and renal damage (as documented by proteinuria) over 4 months of treatment with either sacubitril/valsartan or valsartan; the ability of either treatment to reduce progression of cerebrovascular and renal damage after 2 weeks of high-salt diet...
June 18, 2018: Journal of Hypertension
Polly Fu, Carolyn J Gibson, Wendy Berry Mendes, Michael Schembri, Alison J Huang
OBJECTIVE: The aim of the study was to examine whether anxiety and depressive symptoms are associated with an adverse cardiac autonomic profile among midlife women with hot flashes. METHODS: Anxiety and depressive symptoms were evaluated by validated self-administered questionnaires among peri- and postmenopausal women in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, and respiratory sinus arrhythmia (RSA), a marker of parasympathetic activation, were measured at baseline and 12 weeks using impedance cardiography and electocardiography...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
Dimitrios Oikonomou, Georgios Georgiopoulos, Vassiliki Katsi, Chris Kourek, Constantinos Tsioufis, Alexendra Alexopoulou, Evaggelia Koutli, Dimitrios Tousoulis
OBJECTIVE: To provide a comprehensive review summarizing the existing evidence on the association between nonalcoholic fatty liver disease (NAFLD) and hypertension (HT) independent of other components of metabolic syndrome. METHODS: We searched the literature through Medline and the Cochrane Library for studies evaluating the relationship between hypertension and fatty liver disease. RESULTS: Studies testing this association are limited, but agree that HT and fatty liver disease are inter-related independent of other components of the metabolic syndrome such as obesity and diabetes mellitus...
June 18, 2018: European Journal of Gastroenterology & Hepatology
Miguel F Herrera, Eduardo García-García, Juan F Arellano-Ramos, Miguel Agustín Madero, Jorge Antonio Aldrete-Velasco, Juan Antonio López Corvalá
INTRODUCTION: Metabolic surgery (MS) can be a useful therapeutic strategy in patients with type 2 diabetes (DM2) and obesity. OBJECTIVE: To define the place of MS within DM2 treatment in Mexico. METHODS: A committee of experts consisting of internists and surgeons representing the leading Mexican associations involved in the field was created. Each one responded to a specific question regarding mechanisms involved in controlling DM2, surgical procedures, and the indications and contraindications for MS...
June 18, 2018: Obesity Surgery
L Mozafari, R Amani, B Hamzeh, M H Haghighizadeh, M Bigvand
Introduction: Cardiovascular disease is the main cause of disability and morbidity in many countries. Considering the significance of education in correcting unhealthy eating habits and improving nutritional behaviors that prevents cardiovascular diseases, the current study has been carried out to investigate the impacts of Beliefs, Attitude, Subjective Norms, Enabling Factors (BASNEF)-based educational program on the employees' nutritional behaviors. Materials and Methods: This study was carried out on 120 randomly selected employees of Water and Wastewater Organization of Kermanshah...
January 2018: Journal of Family Medicine and Primary Care
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