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extranodal natural killer cell lymphoma

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https://www.readbyqxmd.com/read/27932776/nasal-type-extranodal-natural-killer-t-nk-t-cell-lymphoma-presenting-as-periorbital-cellulitis-a-case-report
#1
Ma'in Ali Al Shawabkeh, Mansour Al Sulaiti, Hamad Al Sa'ey, Shanmugam Ganesan
BACKGROUND Extranodal lymphoma of the paranasal sinuses is a rare clinical entity seen in only 5-8% of extranodal lymphomas of the head and neck. Nasal natural killer/T cell lymphoma (Nasal NKTCL), which is a subtype of peripheral T cell lymphoma, constitutes about 1.4% of all lymphomas. NKTCL is usually diagnosed at a late stage because it presents with nonspecific symptoms in the early stages. CASE REPORT We report the case of a 25-year-old male patient who presented with periorbital swelling treated as fungal sinusitis but proven to have NKTCL...
December 9, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27917702/effectiveness-of-pegaspargase-gemcitabine-and-oxaliplatin-p-gemox-chemotherapy-combined-with-radiotherapy-in-newly-diagnosed-stage-ie-to-iie-nasal-type-extranodal-natural-killer-t-cell-lymphoma
#2
Wen Wei, Ping Wu, Li Li, Zhi-Hui Zhang
PURPOSE: Extranodal natural killer/T-cell lymphoma (ENKTL), nasal-type, is a distinct subtype of non-Hodgkin lymphoma. ENKTL is sensitive to radiotherapy, but the prognosis is poorer than those of other types of early stage lymphoma. To date, optimal treatment strategies for patients with early stage ENKTL have not been fully defined. METHODS: We retrospectively investigated the efficacy and safety of pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) combined with different dose radiotherapy (RT) in the treatment of 35 newly diagnosed, stage IE to IIE ENKTL patients at our institution from October 2011 to September 2015...
December 5, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27901491/a-comparison-of-treatment-modalities-for-nasal-extranodal-natural-killer-t-cell-lymphoma-in-early-stages-the-efficacy-of-chop-regimen-based-concurrent-chemoradiotherapy
#3
Jianzhong Cao, Shengmin Lan, Liuhai Shen, Hongwei Si, Ning Zhang, Hongwei Li, Ruyuan Guo
This study was designed to evaluate the efficacy of several treatment modalities, including CHOP based concurrent chemoradiotherapy (CCRT), for the patients with stage IE or IIE nasal extranodal NK/T-cell lymphoma (nasal ENKL). The cases were retrieved between 2000 and 2010 (n=94), and were followed to the end of February 2016. The patients were grouped into A (chemotherapy alone; CT alone), B (sequential treatment) and C (CCRT). For those with efficacy evaluation for overall treatment (n=90), CR was attained in 60...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893001/association-of-improved-locoregional-control-with-prolonged-survival-in-early-stage-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#4
Yong Yang, Jian-Zhong Cao, Sheng-Min Lan, Jun-Xin Wu, Tao Wu, Su-Yu Zhu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Li-Ming Xu, Zhi-Yong Yuan, Shu-Nan Qi, Ye-Xiong Li
Importance: The long-term survival benefit for radiotherapy (RT) in early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is not known, and it is unclear whether improved locoregional control (LRC) translates into a survival benefit. Objective: To investigate the dose-dependent effect and potential survival benefits of RT on the basis of LRC improvements. Design, Setting, and Participants: Review of clinical data of patients with early-stage NKTCL at 10 institutions in China between 2000 and 2014...
November 17, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27843135/extended-course-and-increased-dose-of-initial-chemotherapy-for-extranodal-nasal-type-natural-killer-t-nk-t-cell-lymphoma-in-patients-60-years-old-a-single-center-retrospective-cohort-study
#5
Yan Xu, Jin Wang, Wanggang Zhang, Jie Liu, Xingmei Cao, Aili He, Yinxia Chen, Liufang Gu, Bo Lei, Pengyu Zhang, Xiaorong Ma
BACKGROUND Extranodal NK/T-cell lymphoma (ENKTL) of the nasal type is highly invasive and relatively resistant to chemotherapy. This study aimed to assess the efficacy and safety of an extended chemotherapy regimen with increased dose intensity. MATERIAL AND METHODS This was a retrospective cohort study of 69 patients <60 years old with an ECOG score 0-2 treated for ENKTL at the Second Affiliated Hospital of Xi'an Jiaotong University between January 2004 and December 2013. The outcomes were compared between patients who received >8 courses of high-intensity chemotherapy (n=37) vs...
November 11, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27824969/the-early-diagnosis-of-testicular-natural-killer-t-cell-lymphoma
#6
Pei Shu, Wenwu Ling, Chenjing Zhu, Jianchao Wang, Chong Jiang, Weiwei Zhang, Yue Xiao, Xuelei Ma
Testicular natural killer/T-cell lymphoma is a rare aggressive extranodal lymphoma associated with Epstein-Barr virus infection. Time to diagnose is crucial as the disease is rapidly progressive and fatal. Early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/T-cell lymphoma. However, no reports have described the results of imaging studies. In this paper, contrast-enhanced ultrasonography (CEUS), fluorine-18-fuorodexoyglucose-positron emission tomography/computed tomography ((18)F-FDG PET/CT) and tumor biopsies were all diagnostic of testicular natural killer/T-cell lymphoma...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27801344/-the-significance-of-peripheral-blood-natural-killer-cell-surface-cd107a-nkg2d-and-serum-smica-in-patients-with-extranodal-nk-t-cell-lymphoma-nasal-type
#7
J X Liu, J W Wang, X Y Cui
The expression of CD107a, NKG2D on the surface of natural killer (NK) cells and serum soluble major histocompatibility complex class Ⅰ chain-related A (sMICA) level in patients with extranodal NK/T cell lymphoma, nasal type (ENKL) were detected.We found that CD107a expression was reduced on the surface of NK cells, suggesting impaired NK cell activity in ENKL patients, which may result from decreased NKG2D expression.
November 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27785062/chemotherapy-combined-with-high-dose-extended-field-radiotherapy-for-stage-i-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#8
Jialin Luo, Caineng Cao, Yuan Zhu, Peng Liu, Luying Liu, Ke Lu, Na Zhang, Ning Zhou
BACKGROUND AND OBJECTIVE: The objective of the study was to evaluate the efficiency of chemotherapy (CT) combined with high-dose extended-field radiotherapy (RT) in stage I extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). PATIENTS AND METHODS: Between January 2001 and November 2010, 103 stage I extranodal nasal-type NKTCL patients were retrospectively analyzed. Of these patients, 75 patients were treated by RT plus CT and 28 patients were treated by RT alone...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27752533/cd56-extranodal-natural-killer-nk-t-cell-lymphoma-nasal-type-presenting-as-skin-ulcers-in-a-white-man
#9
Charles Vainder, Jonhan Ho, Steven H Swerdlow, Oleg E Akilov
No abstract text is available yet for this article.
September 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27749560/pyoderma-gangrenosum-preceding-the-onset-of-extranodal-natural-killer-t-cell-lymphoma-a-case-report
#10
Ting-Hua Yang, Chung-Hong Hu, Hsiou-Hsin Tsai
INTRODUCTION: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that may be associated with systemic diseases. The association of PG with lymphoid malignancies has rarely been reported. Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare but aggressive entity with a poor prognosis. Here, we report the case of a patient who had idiopathic PG refractory to systemic steroids and subsequently developed ENKTL. CASE REPORT: A 70-year-old man presented with a 2-month history of intermittent fever and multifocal painful papules, plaques, and ulcerations on his extremities...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27749404/intratumoral-heterogeneity-of-pretreatment-18f-fdg-pet-images-predict-disease-progression-in-patients-with-nasal-type-extranodal-natural-killer-t-cell-lymphoma
#11
Kuan-Yin Ko, Chia-Ju Liu, Chi-Lun Ko, Ruoh-Fang Yen
PURPOSE: The aim of this study was to investigate whether the textural features of pretreatment F-FDG PET images can predict prognosis for nasal type extranodal natural killer/T-cell lymphoma (ENKTL). MATERIALS AND METHODS: A retrospective analysis of the pretreatment F-FDG PET images of the patients with newly diagnosed nasal type ENKTL from 2008 to 2013 was conducted. Progression-free survival (PFS) was the main outcome measure. The primary tumor was identified and then delineated using the 40% maximum standardized uptake value (SUVmax) thresholding method...
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27732828/targeting-cd38-in-refractory-extranodal-natural-killer-cell-t-cell-lymphoma
#12
LETTER
Parameswaran Hari, Renju V Raj, Horatiu Olteanu
No abstract text is available yet for this article.
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27729836/mutational-analysis-of-extranodal-nk-t-cell-lymphoma-using-targeted-sequencing-with-a-comprehensive-cancer-panel
#13
Seungkyu Choi, Jai Hyang Go, Eun Kyung Kim, Hojung Lee, Won Mi Lee, Chun-Sung Cho, Kyudong Han
Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NKTCL), is a malignant disorder of cytotoxic lymphocytes of NK or T cells. It is an aggressive neoplasm with a very poor prognosis. Although extranodal NKTCL reportedly has a strong association with Epstein-Barr virus, the molecular pathogenesis of NKTCL has been unexplored. The recent technological advancements in next-generation sequencing (NGS) have made DNA sequencing cost- and time-effective, with more reliable results. Using the Ion Proton Comprehensive Cancer Panel, we sequenced 409 cancer-related genes to identify somatic mutations in five NKTCL tissue samples...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27723108/a-phase-2-study-of-methotrexate-etoposide-dexamethasone-and-pegaspargase-chemotherapy-for-newly-diagnosed-relapsed-or-refractory-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-multicenter-trial-in-northwest-china
#14
Rong Liang, Guang-Xun Gao, Jie-Ping Chen, Ji-Shi Wang, Xiao-Min Wang, Yun Zeng, Qing-Xian Bai, Tao Zhang, Lan Yang, Bao-Xia Dong, Hong-Tao Gu, Mi-Mi Shu, Cai-Xia Hao, Jian-Hong Wang, Na Zhang, Xie-Qun Chen
The nasal type of extranodal natural killer/T-cell lymphoma is a rare aggressive lymphoma with poor prognosis. To discover a successful treatment, we investigated the efficacy and safety of chemotherapy with methotrexate, etoposide, dexamethasone, and polyethylene glycol-asparaginase (MESA). Three cycles of MESA were administered to 46 patients with new or relapsed/refractory natural killer/T-cell lymphoma. Complete response after 3 treatment cycles was 43.5%, the overall response rate was 87%, and 2-year overall survival was 83...
October 10, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27719716/-efficacy-of-glide-chemotherapy-for-patients-with-newly-diagnosed-advanced-stage-or-relapsed-refractory-extranodal-natural-killer-cell-lymphoma
#15
J Ji, B Xiang, Z G Liu, Y Q Jia, H L Zhu, T Niu, L Pan, H Chang, J Huang, Y Wu, J J Li, C He, H B Ma, Y Tang, T Dong, T Liu
Objective: To evaluate the efficacy of gemcitabine, asparaginase , ifosfamide, dexamethasone and etoposide (GLIDE) combination for patients with newly diagnosed advanced-stage or relapsed/refractory extranodal natural killer cell lymphoma (ENKL). Methods: Fourty-two newly diagnosed advanced-stage or relapsed/refractory ENKL were enrolled from March 2010 to March 2016. Patients were treated with GLIDE for median 3 (2-6) cycles. Complete response (CR) rate, early CR (after 2 cycles) rate were evaluated after all treatment finished...
September 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27696202/expression-of-programmed-cell-death-1-and-programmed-cell-death-ligand-1-in-extranodal-nk-t-cell-lymphoma-nasal-type
#16
Jae-Cheol Jo, Misung Kim, Yunsuk Choi, Hyun-Jung Kim, Ji Eun Kim, Seoung Wan Chae, Hawk Kim, Hee Jeong Cha
Programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) are new therapeutic targets in cancer immunotherapy. The aim of this study was to investigate the clinicopathological characteristics of PD-1 and PD-L1 expression in extranodal natural killer/T‑cell lymphoma, nasal type (ENKTL). We performed PD-1 and PD-L1 immunostaining in 79 ENKTL biopsy samples and retrospectively analyzed medical records of all 79 patients from four tertiary referral hospitals. The expression of PD-1 and PD-L1 by tumor cells and/or infiltrating immune cells was evaluated...
October 3, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27692503/a-14-year-old-boy-with-extranodal-natural-killer-cell-lymphoma-of-the-nose-nasopharynx-larynx-and-trachea-in-remission-6years-after-primary-diagnosis-a-longitudinal-case-report
#17
Anil Gungor, Lindsey Pennington, Senthil Sankararaman, Samer Zaid-Kaylani, Majed Aldin Jeroudi
Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subtypes. ENKTL, nasal type occurs in the nose and can extend to the upper aero-digestive tract as reported in this longitudinal case study. This is a longitudinal report of progress of a 14-year-old boy with ENKTL originating in the nasal cavity with subsequent extension and recurrence in the contralateral nose, nasopharynx, larynx and trachea presenting with varying degrees of respiratory problems and eventually, respiratory distress...
August 12, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27680487/extranodal-natural-killer-t-cell-lymphoma-nasal-type-with-primary-manifestation-as-an-upper-eyelid-swelling
#18
Akiko Kanzaki, Yoko Funasaka, Munenaga Nakamizo, Ayaka Shima, Takeshi Ryotokuji, Kazuo Dan, Mika Terasaki, Yuichi Sugisaki, Yu Fukuda, Seiji Kawana, Hidehisa Saeki
Extranodal natural killer/T-cell lymphoma (ENK/TCL) is most often in the nose or the nasopharynx but can present elsewhere. We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. A biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. Treatment with oral prednisolone at a dosage of 20 mg/day decreased the eyelid swelling...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27675682/alarming-rates-of-omission-or-inadequate-radiation-therapy-in-extranodal-natural-killer-t-cell-lymphoma-nasal-type-in-the-united-states
#19
J Vargo, G K Balasubramani, S Beriwal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27658861/successful-treatment-of-extranodal-natural-killer-t-cell-lymphoma-associated-hemophagocytic-lymphohistiocytosis-with-meda-chemotherapy
#20
Da-Hui Li, Xiao-Yan Zhang, Chao Du, Wen-Hao Zhang, Jun Chang, Yu-Jie Ma, Zhi-Chao Li, Si-Guo Hao, Hao Ding, Rong Tao
No abstract text is available yet for this article.
September 23, 2016: Leukemia & Lymphoma
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