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extranodal natural killer cell lymphoma

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https://www.readbyqxmd.com/read/28194321/extranodal-natural-killer-t-cell-lymphoma-presenting-as-orbital-cellulitis
#1
Hanis Zuhaimy, Hayati Abdul Aziz, Suresh Vasudevan, Siah Hui Hui
Objective: To report an aggressive case of extranodal natural killer/T-cell lymphoma (NKTCL) of the ethmoid sinus presenting as orbital cellulitis Method: Case report Results: A 56-year-old male presented with right eye redness, reduced vision, and periorbital swelling for 5 weeks duration associated with a two-month history of blocked nose. The visual acuity of the right eye was 6/18. The eye was proptosed with periorbital oedema and conjunctival chemosis. The pupil was mid-dilated but there was no relative afferent pupillary defect...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28193996/a-case-report-of-primary-nasal-natural-killer-nk-t-cell-lymphoma-in-an-african-american-patient-presenting-with-hemophagocytic-syndrome
#2
Bowei Tan, Cherif Abdelmalek, James E O'Donnell, Thomas Toltaku, Rashid Chaudhry, Jen C Wang, Vladimir Gotlieb
BACKGROUND Extranodal natural killer/T-cell lymphoma, nasal type (ENKTCL) is generally an aggressive and rare non-Hodgkin lymphoma. It is most common in East Asians, Native Americans, and South Americans, but is rarely reported in blacks. CASE REPORT A 55-year-old African American male born in Grenada presented with a left nostril mass with facial swelling and biopsy subsequently confirmed a diagnosis of extranodal NK/T-cell lymphoma, nasal type (ENKTCL). Immunochemistry was positive for CD2, cytoplasmic CD3, CD7, CD 43, CD 56, granzyme B, and TIA-1...
February 14, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28191809/unusual-destruction-of-the-nasal-septum
#3
Tarek Assi, Elie El Rassy, Tania Moussa, Samer Tabchi, Ralph Chebib, Marwan Ghosn
Extranodal Natural Killer/T-cell lymphoma (ENKTL) is the most common cause of nasal cell lymphoma. It manifests by progressive destruction of the facial midline features with nasal obstruction and local destruction of soft tissue. Therefore, establishing the diagnosis of this disease tends to be difficult. This is attributed to an extensive differential diagnosis of infectious, autoimmune, neoplastic and inflammatory etiologies. We herein report the case of a 63-year-old female who presented to our department for persistent nasal congestion resistant to symptomatic treatment that was found to have an ENKTL...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28119527/runx3-is-oncogenic-in-natural-killer-t-cell-lymphoma-and-is-transcriptionally-regulated-by-myc
#4
V Selvarajan, M Osato, G S S Nah, J Yan, C Tae-Hoon, Dc-C Voon, Y Ito, M F Ham, M Salto-Tellez, N Shimizu, S-N Choo, S Fan, W-J Chng, S-B Ng
RUNX3, runt-domain transcription factor, is a master regulator of gene expression in major developmental pathways. It acts as a tumor suppresser in many cancers but is oncogenic in certain tumors. We observed upregulation of RUNX3 mRNA and protein expression in nasal-type extranodal NK/T-cell lymphoma (NKTL) patient samples and NKTL cell lines compared to normal NK cells. RUNX3 silenced NKTL cells showed increased apoptosis and reduced cell proliferation. Potential binding sites for MYC were identified in the RUNX3 enhancer region...
January 25, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28117395/utility-of-baseline-interim-and-end-of-treatment-18-f-fdg-pet-ct-in-extranodal-natural-killer-t-cell-lymphoma-patients-treated-with-l-asparaginase-pegaspargase
#5
Yu Chang, Xiaorui Fu, Zhenchang Sun, Xinli Xie, Ruihua Wang, Zhaoming Li, Xudong Zhang, Guangyao Sheng, Mingzhi Zhang
Positron emission tomography-computed tomography (PET/CT) is widely used for initial staging and monitoring treatment responses in Hodgkin and diffuse large B-cell lymphoma. However, its prognostic value in extranodal natural killer (NK)/T-cell lymphoma (ENKL) remains unclear. Here, we conducted a retrospective study to determine the impact of PET/CT in ENKL. Fifty-two patients newly diagnosed with ENKL were enrolled. Baseline maximum standardized uptake values (SUVmax), whole-body metabolic tumor volume (WBMTV) and whole-body total lesion glycolysis (WBTLG) were recorded...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101356/a-case-report-of-primary-cutaneous-natural-killer-t-cell-lymphoma
#6
Chen Tian, Yong Yu, Yizhuo Zhang
Primary cutaneous extranodal natural killer/T-cell lymphoma, nasal type (ENKL-NT) is a relatively rare disease associated with aggressive tumor-cell behavior and poor prognosis. Progress in immunohistochemistry has improved the identification of ENKL-NT. The present case study reported on a 64-year-old female patient presenting with several red nodular lesions on the neck developed over four months. Cutaneous biopsy revealed these cells were positive for CD3, CD56, CD5, CD8 and negative for CD2, CD34, CD7, CD20 and Granzyme B...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28101353/clinical-characteristics-and-treatment-of-69-patients-with-extranodal-natural-killer-t-cell-lymphoma
#7
Yuyan Guo, Enxiao Li, Liping Song, Yinying Wu
This study was conducted to retrospectively analyze the clinical characteristics and survival of patients with extranodal natural killer-T cell lymphoma (ENKL) and compare different treatment regimens. The univariate analysis demonstrated that survival was worse for patients with extranasal primary tumors, Eastern Cooperative Oncology Group performance status (ECOG PS) scores of ≥2, International Prognostic Index (IPI) scores of 3-5, Ann Arbor stage III and IV disease, B symptoms, lymph node involvement and absence of radiotherapy...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28034070/treatments-and-outcomes-of-patients-with-extranodal-natural-killer-t-cell-lymphoma-diagnosed-between-2000-and-2013-a-cooperative-study-in-japan
#8
Motoko Yamaguchi, Ritsuro Suzuki, Masahiko Oguchi, Naoko Asano, Jun Amaki, Takeshi Akiba, Takeshi Maeda, Satoshi Itasaka, Nobuko Kubota, Yoshihiro Saito, Yukio Kobayashi, Jun Itami, Kyoko Ueda, Kana Miyazaki, Noriko Ii, Naoto Tomita, Nodoka Sekiguchi, Jun Takizawa, Bungo Saito, Tohru Murayama, Toshihiko Ando, Hideho Wada, Rie Hyo, Yasuo Ejima, Masatoshi Hasegawa, Naoyuki Katayama
Purpose To elucidate the management and outcomes of patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL), who were diagnosed between 2000 and 2013 in Japan. Patients and Methods Data from 358 patients with ENKL diagnosed between 2000 and 2013 from 31 institutes were retrospectively analyzed. Results Patients' median age was 58 years, and 257 (72%) had localized disease. The most common first-line treatment was radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC) (66%) for localized ENKL and L-asparaginase-containing chemotherapy (30%) for advanced ENKL...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28009988/a-neutralized-human-lmp1-igg-inhibits-enktl-growth-by-suppressing-the-jak3-stat3-signaling-pathway
#9
Yuan Mao, Jun Wang, Mingzhi Zhang, Weifei Fan, Qi Tang, Siping Xiong, Xiaojun Tang, Juqing Xu, Lin Wang, Shu Yang, Suyao Liu, Li Xu, Yan Chen, Lin Xu, Rong Yin, Jin Zhu
Latent membrane protein 1 (LMP1), which is associated with the development of different types of Epstein-Barr virus (EBV) related lymphoma, has been suggested to be an important oncoprotein. In this study, a human anti-LMP1 IgG antibody (LMP1-IgG) was constructed and characterized by ELISA, western blotting (WB), affinity and immunohistochemistry (IHC) analyses. CCK-8, MTT, apoptosis assays, antibody-dependent cell-mediated cytotoxicity (ADCC) and CDC (complement-dependent cytotoxicity) assays were performed to evaluate the inhibitory effects of LMP1-IgG on extranodal nasal-type natural killer (NK)/T-cell lymphoma (ENKTL)...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28003113/lymphoma-in-taiwan-review-of-1347-neoplasms-from-a-single-institution-according-to-the-2016-revision-of-the-world-health-organization-classification
#10
Shih-Sung Chuang, Shang-Wen Chen, Sheng-Tsung Chang, Yu-Ting Kuo
BACKGROUND: Lymphoid neoplasms are heterogeneous and types of lymphoma vary in different geographic regions. In this study, we aimed at classifying the lymphoid neoplasms at our institution in Taiwan and to compare the relative frequency of various types of lymphoma in different countries. METHODS: We retrospectively searched the files of patients diagnosed with lymphoma at our institution from 2000 to 2015 based on the 2016 Revision of the World Health Organization classification...
December 18, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28002803/increased-body-mass-index-is-associated-with-improved-overall-survival-in-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#11
Ya-Jun Li, Ping-Yong Yi, Ji-Wei Li, Xian-Ling Liu, Xi-Yu Liu, Fang Zhou, Zhou OuYang, Zhong-Yi Sun, Li-Jun Huang, Jun-Qiao He, Yuan Yao, Zhou Fan, Tian Tang, Wen-Qi Jiang
OBJECTIVES: The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL. METHODS: We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (≥ 20...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/28002792/radiotherapy-improves-survival-in-early-stage-extranodal-natural-killer-t-cell-lymphoma-patients-receiving-asparaginase-based-chemotherapy
#12
Yi-Yang Li, Ling-Ling Feng, Shao-Qing Niu, Han-Yu Wang, Lu-Lu Zhang, Liang Wang, Zhong-Jun Xia, Hui-Qiang Huang, Yun-Fei Xia, Yu-Jing Zhang, Xi-Cheng Wang
This study retrospectively investigated asparaginase-based chemotherapy treatment outcomes with or without radiotherapy in 143 patients with stage IE-IIE extranodal natural killer/T cell lymphoma (ENKTCL). All patients received a median of three cycles of asparaginase-based chemotherapy, while 121 patients received radiotherapy following the chemotherapy. The complete remission (CR) rate for all patients post-chemotherapy was 58.7%, and rose to 73.4% by the end of treatment. Patients who received radiotherapy achieved better survival outcomes than those who did not (89...
December 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27932776/nasal-type-extranodal-natural-killer-t-nk-t-cell-lymphoma-presenting-as-periorbital-cellulitis-a-case-report
#13
Ma'in Ali Al Shawabkeh, Mansour Al Sulaiti, Hamad Al Sa'ey, Shanmugam Ganesan
BACKGROUND Extranodal lymphoma of the paranasal sinuses is a rare clinical entity seen in only 5-8% of extranodal lymphomas of the head and neck. Nasal natural killer/T cell lymphoma (Nasal NKTCL), which is a subtype of peripheral T cell lymphoma, constitutes about 1.4% of all lymphomas. NKTCL is usually diagnosed at a late stage because it presents with nonspecific symptoms in the early stages. CASE REPORT We report the case of a 25-year-old male patient who presented with periorbital swelling treated as fungal sinusitis but proven to have NKTCL...
December 9, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27917702/effectiveness-of-pegaspargase-gemcitabine-and-oxaliplatin-p-gemox-chemotherapy-combined-with-radiotherapy-in-newly-diagnosed-stage-ie-to-iie-nasal-type-extranodal-natural-killer-t-cell-lymphoma
#14
Wen Wei, Ping Wu, Li Li, Zhi-Hui Zhang
PURPOSE: Extranodal natural killer/T-cell lymphoma (ENKTL), nasal-type, is a distinct subtype of non-Hodgkin lymphoma. ENKTL is sensitive to radiotherapy, but the prognosis is poorer than those of other types of early stage lymphoma. To date, optimal treatment strategies for patients with early stage ENKTL have not been fully defined. METHODS: We retrospectively investigated the efficacy and safety of pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) combined with different dose radiotherapy (RT) in the treatment of 35 newly diagnosed, stage IE to IIE ENKTL patients at our institution from October 2011 to September 2015...
December 5, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27901491/a-comparison-of-treatment-modalities-for-nasal-extranodal-natural-killer-t-cell-lymphoma-in-early-stages-the-efficacy-of-chop-regimen-based-concurrent-chemoradiotherapy
#15
Jianzhong Cao, Shengmin Lan, Liuhai Shen, Hongwei Si, Ning Zhang, Hongwei Li, Ruyuan Guo
This study was designed to evaluate the efficacy of several treatment modalities, including CHOP based concurrent chemoradiotherapy (CCRT), for the patients with stage IE or IIE nasal extranodal NK/T-cell lymphoma (nasal ENKL). The cases were retrieved between 2000 and 2010 (n=94), and were followed to the end of February 2016. The patients were grouped into A (chemotherapy alone; CT alone), B (sequential treatment) and C (CCRT). For those with efficacy evaluation for overall treatment (n=90), CR was attained in 60...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893001/association-of-improved-locoregional-control-with-prolonged-survival-in-early-stage-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#16
Yong Yang, Jian-Zhong Cao, Sheng-Min Lan, Jun-Xin Wu, Tao Wu, Su-Yu Zhu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Li-Ming Xu, Zhi-Yong Yuan, Shu-Nan Qi, Ye-Xiong Li
Importance: The long-term survival benefit for radiotherapy (RT) in early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is not known, and it is unclear whether improved locoregional control (LRC) translates into a survival benefit. Objective: To investigate the dose-dependent effect and potential survival benefits of RT on the basis of LRC improvements. Design, Setting, and Participants: Review of clinical data of patients with early-stage NKTCL at 10 institutions in China between 2000 and 2014...
January 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/27843135/extended-course-and-increased-dose-of-initial-chemotherapy-for-extranodal-nasal-type-natural-killer-t-nk-t-cell-lymphoma-in-patients-60-years-old-a-single-center-retrospective-cohort-study
#17
Yan Xu, Jin Wang, Wanggang Zhang, Jie Liu, Xingmei Cao, Aili He, Yinxia Chen, Liufang Gu, Bo Lei, Pengyu Zhang, Xiaorong Ma
BACKGROUND Extranodal NK/T-cell lymphoma (ENKTL) of the nasal type is highly invasive and relatively resistant to chemotherapy. This study aimed to assess the efficacy and safety of an extended chemotherapy regimen with increased dose intensity. MATERIAL AND METHODS This was a retrospective cohort study of 69 patients <60 years old with an ECOG score 0-2 treated for ENKTL at the Second Affiliated Hospital of Xi'an Jiaotong University between January 2004 and December 2013. The outcomes were compared between patients who received >8 courses of high-intensity chemotherapy (n=37) vs...
November 11, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27824969/the-early-diagnosis-of-testicular-natural-killer-t-cell-lymphoma
#18
Pei Shu, Wenwu Ling, Chenjing Zhu, Jianchao Wang, Chong Jiang, Weiwei Zhang, Yue Xiao, Xuelei Ma
Testicular natural killer/T-cell lymphoma is a rare aggressive extranodal lymphoma associated with Epstein-Barr virus infection. Time to diagnose is crucial as the disease is rapidly progressive and fatal. Early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/T-cell lymphoma. However, no reports have described the results of imaging studies. In this paper, contrast-enhanced ultrasonography (CEUS), fluorine-18-fuorodexoyglucose-positron emission tomography/computed tomography ((18)F-FDG PET/CT) and tumor biopsies were all diagnostic of testicular natural killer/T-cell lymphoma...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27801344/-the-significance-of-peripheral-blood-natural-killer-cell-surface-cd107a-nkg2d-and-serum-smica-in-patients-with-extranodal-nk-t-cell-lymphoma-nasal-type
#19
J X Liu, J W Wang, X Y Cui
The expression of CD107a, NKG2D on the surface of natural killer (NK) cells and serum soluble major histocompatibility complex class Ⅰ chain-related A (sMICA) level in patients with extranodal NK/T cell lymphoma, nasal type (ENKL) were detected.We found that CD107a expression was reduced on the surface of NK cells, suggesting impaired NK cell activity in ENKL patients, which may result from decreased NKG2D expression.
November 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27785062/chemotherapy-combined-with-high-dose-extended-field-radiotherapy-for-stage-i-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#20
Jialin Luo, Caineng Cao, Yuan Zhu, Peng Liu, Luying Liu, Ke Lu, Na Zhang, Ning Zhou
BACKGROUND AND OBJECTIVE: The objective of the study was to evaluate the efficiency of chemotherapy (CT) combined with high-dose extended-field radiotherapy (RT) in stage I extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). PATIENTS AND METHODS: Between January 2001 and November 2010, 103 stage I extranodal nasal-type NKTCL patients were retrospectively analyzed. Of these patients, 75 patients were treated by RT plus CT and 28 patients were treated by RT alone...
2016: OncoTargets and Therapy
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