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extranodal natural killer cell lymphoma

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https://www.readbyqxmd.com/read/28529616/lymphocyte-monocyte-ratio-is-a-novel-predictor-for-early-stage-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#1
Qiao-Xuan Wang, Shao-Hua Li, Bao-Yan Ji, Han-Yu Wang, Yi-Yang Li, Ling-Ling Feng, Kai Chen, Yun-Fei Xia, Yu-Jing Zhang
Objective: Great heterogeneity exists in clinical behavior and survival outcome in patients with stage IE/IIE extranodal natural killer/T-cell lymphoma, nasal type (ENKTL). In this study, we proposed lymphocyte/monocyte ratio (LMR) as a new prognostic factor for these early stage ENKTL. Methods: We retrospectively examined the LMR as a prognostic variable in a cohort of 379 patients with newly diagnosed stage IE/IIE ENKTL. The relationship between the LMR and clinicopathologic variables were analyzed in Kaplan-Meier log-rank survival analysis, and the Cox proportional hazards model was used to determine the survival significance of the LMR for both progression-free survival (PFS) and overall survival (OS)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28486951/cd30-expression-in-extranodal-natural-killer-t-cell-lymphoma-nasal-type-among-622-cases-of-mature-t-cell-and-natural-killer-cell-lymphoma-at-a-single-institution-in-south-china
#2
Yanfen Feng, Huilan Rao, Yiyan Lei, Yuhua Huang, Fang Wang, Yu Zhang, Shaoyan Xi, Qiuliang Wu, Jianyong Shao
BACKGROUND: Mature T-cell and natural killer (NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas, and extranodal NK/T-cell lymphoma, nasal type (ENKTL) is an aggressive subtype with sporadic CD30 expression. However, the significance of CD30 expression in ENKTL is controversial. We aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas according to the 2016 World Health Organization (WHO) classification guidelines and to study the association between CD30 expression and prognosis of patients with ENKTL...
May 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28475009/prognostic-impact-of-absolute-lymphocyte-count-absolute-monocyte-count-ratio-and-prognostic-score-in-patients-with-nasal-type-extranodal-natural-killer-t-cell-lymphoma
#3
Na Li, Li Zhang, Hao-Lan Song, Jing Zhang, Hua-Wei Weng, Li-Qun Zou
Nasal-type, extranodal natural killer/T-cell lymphoma is a heterogeneous disorder with poor prognosis, requiring risk stratification in this population. The combined value of baseline absolute lymphocyte count and absolute monocyte count provided prognostic information in some malignancies. However, the evidence requires validation in extranodal natural killer/T-cell lymphoma. Aiming to investigate the prognostic significance of absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score for extranodal natural killer/T-cell lymphoma, a retrospective research was carried out...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28474639/primary-cutaneous-extranodal-natural-killer-t-cell-lymphoma-presenting-as-bilateral-erythematous-patches-on-the-arms
#4
Ik Jun Moon, Hyun Ji Kang, Mi Woo Lee, Woo Jin Lee
Natural killer/T-cell lymphoma is a rare, Epstein-Barr virus-associated type of cytotoxic lymphoma thatpresents mainly in the nasal cavity and its vicinity. Very few cases of primary cutaneous extranodal natural killer/T-cell lymphoma have been reported till date. All the previously reported cases of primary cutaneous extranodalnatural killer/T-cell lymphoma presented as lesions resembling cellulitis, subcutaneous nodules or ulcers. We report a rare case which presented as erythematous and purpuric round patches on the arms and was finally diagnosed as primary cutaneous extranodalnatural killer/T-cell lymphoma, following a skin biopsy...
April 27, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28454236/prognostic-significance-of-cd30-expression-in-nasal-natural-killer-t-cell-lymphoma
#5
Guan-Nan Wang, Wu-Gan Zhao, Ling Li, Dan-Dan Zhang, Xian-Zheng Gao, Jun Zhou, Lei Zhang, Xiao-Rui Fu, Xiang-Yu Zheng, Ye Li, Zhen Li, Ming-Zhi Zhang, Wen-Cai Li
The present study aimed to investigate the expression of tumor necrosis factor receptor superfamily member 8 (CD30) in extranodal natural killer/T-cell lymphoma (ENKTL) using immunohistochemistry, and to evaluate the association between CD30 and clinicopathological and prognostic significance. CD30 expression was detected using immunohistochemistry on paraffin-embedded sections obtained from 122 patients with ENKTL prior to treatment. In total, 70 of these patients with complete clinical data were collected for prognostic analysis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28443316/extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-rare-but-critical-diagnosis
#6
Andrew Schuler, Emily Smith, Lori Lowe, Yolanda Helfrich
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28423724/intensity-modulated-radiotherapy-has-superior-outcomes-to-three-dimensional-conformal-radiotherapy-in-patients-with-stage-ie-iie-extranodal-nasal-type-natural-killer-t-cell-lymphoma
#7
Yi-Yang Li, Hai-Qun Lin, Lu-Lu Zhang, Ling-Ling Feng, Shao-Qing Niu, Han-Yu Wang, Yu-Jing Zhang, Xi-Cheng Wang
We compared the treatment outcomes, toxicities and prognoses of patients with stage IE-IIE extranodal natural killer/T-cell lymphoma (ENKTL) treated with intensity-modulated radiotherapy (IMRT) or three-dimensional conformal radiotherapy (3DCRT). Newly diagnosed early-stage ENKTL patients (N = 173) were enrolled and received extended involved-field radiotherapy following induction chemotherapy. Patients were treated with 3DCRT (n = 98) or IMRT (n = 75). One-to-one matching of the IMRT and 3DCRT groups was performed through propensity score matching, which yielded 23 pairs of patients...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413664/extranodal-natural-killer-t-cell-lymphoma-presenting-as-cavernous-sinus-syndrome
#8
Hong-Cheng Mai, Dan-Xia Chen, Dan Lu, Yu-Sheng Zhang
Extranodal natural killer (NK)/T-cell lymphomas are rare, highly aggressive tumors of the central nervous system (CNS) that commonly affect the nasal cavity or paranasal sinuses. NK/T-cell lymphomas are associated with a poor prognosis, as they exhibit a wide range of unique clinical presentations and neuroimaging findings that are currently difficult to detect. Pathological examination is considered to be more reliable for defining the pathological entity of NK/T-cell lymphoma. Early testing for fluorodeoxyglucose (FDG)-positron emission tomography combined with computed tomography may improve the evaluation of lymphomas, which have been known to display avid (18)FDG uptake...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28410601/the-diagnosis-and-management-of-nk-t-cell-lymphomas
#9
REVIEW
Eric Tse, Yok-Lam Kwong
Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignancy of putative NK-cell origin, with a minority deriving from the T-cell lineage. Pathologically, the malignancy occurs in two forms, extranodal NK/T-cell lymphoma, nasal type; and aggressive NK-cell leukaemia. Lymphoma occur most commonly (80%) in the nose and upper aerodigestive tract, less commonly (20%) in non-nasal areas (skin, gastrointestinal tract, testis, salivary gland), and rarely as disseminated disease with a leukemic phase...
April 14, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28410236/development-of-new-prognostic-model-based-on-pretreatment-%C3%AE-lri-and-llri-for-stage-ie-iie-upper-aerodigestive-tract-enktl-nasal-type
#10
Wumin Dai, Bo Jia, Jianliang Yang, Shengyu Zhou, Peng Liu, Xiaohui He, Yan Qin, Lin Gui, Changgong Zhang, Xiaohong Han, Yan Sun, Yuankai Shi
To identify simple non-invasive prognostic factors for extranodal natural killer/T cell lymphoma (ENKTL), we have investigated the prognostic value of pretreatment β2-microglobin to lymphocytes ratio index (βLRI) or lactate dehydrogenase to lymphocytes ratio index (LLRI), by analyzing the retrospective data from 211 ENKTL patients. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value of pretreatment βLRI and LLRI. The univariate analysis indicated that Ann Arbor Stage (p = 0...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28406802/distinct-subtype-distribution-and-somatic-mutation-spectrum-of-lymphomas-in-east-asia
#11
Weicheng Ren, Wei Li, Xiaofei Ye, Hui Liu, Qiang Pan-Hammarström
PURPOSE OF REVIEW: Here, we give an updated overview of the subtype distribution of lymphomas in East Asia and also present the genome sequencing data on two major subtypes of these tumors. RECENT FINDINGS: The distribution of lymphoma types/subtypes among East Asian countries is very similar, with a lower proportion of B-cell malignancies and a higher proportion of T/natural killer (NK)-cell lymphomas as compared to Western populations. Extranodal NK/T-cell lymphoma is more frequently observed in East Asia, whereas follicular lymphoma and chronic lymphocytic leukemia, are proportionally lower...
April 13, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28404973/a-phase-ii-prospective-study-of-the-sandwich-protocol-l-asparaginase-cisplatin-dexamethasone-and-etoposide-chemotherapy-combined-with-concurrent-radiation-and-cisplatin-in-newly-diagnosed-i-ii-stage-nasal-type-extranodal-natural-killer-t-cell-lymphoma
#12
Ming Jiang, Li Zhang, Li Xie, Hong Zhang, Yu Jiang, Wei-Ping Liu, Wen-Yan Zhang, Rong Tian, Yao-Tiao Deng, Sha Zhao, Li-Qun Zou
Nasal-type, extranodal NK/T cell lymphoma (ENKTCL) is a special type of lymphomas with geographic and racial specificity. Up to now, the standard first-line treatment is still not unified. In our previous report, the "sandwich" protocol produced good results. Continuing to use the "sandwich" mode, a new chemotherapy composed of L-asparaginase, cisplatin, etoposide and dexamethasone (LVDP) plus concurrent chemoradiotherapy (CCRT) was conducted in more patients with newly diagnosed, I/II stage ENKTCL. The results showed that 66 patients were enrolled...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28398275/natural-killer-t-cell-lymphomas-in-pediatric-and-adolescent-patients
#13
REVIEW
Amanda M Termuhlen
Natural killer/T-cell (NK/T-cell) lymphomas are rare in children and adolescents and consist predominantly of nasal-type extranodal NK/T-cell lymphomas. More than half of pediatric/adolescent patients with NK/T-cell lymphomas present with localized nasal/sinus involvement, but the disease may involve many organs. NK/T-cell lymphoma cells are cytotoxic and associated with necrosis and angioinvasion; they express CD56, CD2, cytoplasmic CD3 epsilon, and to a variable degree CD30. The cells contain Epstein-Barr virus (EBV)-encoded RNA...
March 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28393058/extranodal-nk-t-cell-lymphoma-with-destruction-of-the-uvulae-a-case-report
#14
Farahzad Jabbari Azad, Zahra Delavarian, Masoud Hatami, Hosein Rahimi, Mohammad Reza Abdolvahed
INTRODUCTION: Extranodal Natural Killer (NK)/T-cell lymphoma (NKTCL) nasal type is a rare but well-known disease with poor prognosis. NKTCL is more prevalent in Asia and comprises about 7-10% of all non-Hodgkin lymphoma cases in this region. The characteristic clinical pattern of NKTCL is the destruction of the midline structures of the mid-face. CASE REPORT: The present study examines a case of NKTCL in a 23-year-old man with a destructive ulcer of the palate and uvulae...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28380259/the-impact-of-the-omission-or-inadequate-dosing-of-radiotherapy-in-extranodal-natural-killer-t-cell-lymphoma-nasal-type-in-the-united-states
#15
John A Vargo, Arisha Patel, Scott M Glaser, Goundappa K Balasubramani, Rafic J Farah, Stanley M Marks, Sushil Beriwal
BACKGROUND: Extranodal natural killer T-cell lymphoma, nasal-type (NKTCL), is a rare malignancy in Western populations and is thus challenging for standardization of care and a prospective study. This study was aimed at defining patterns of care for NKTCL in the context of radiotherapy (RT) use and dose selection in the United States. METHODS: Six hundred forty-two stage I-II NKTCL patients from 1998 to 2012 were identified from the National Cancer Data Base. Binary logistic regression analyses were performed to identify sociodemographic, treatment, and tumor characteristics predictive of the treatment selection and RT dose...
April 5, 2017: Cancer
https://www.readbyqxmd.com/read/28340876/clinical-features-and-current-optimal-management-of-natural-killer-t-cell-lymphoma
#16
REVIEW
Shinichi Makita, Kensei Tobinai
Extranodal natural killer/T-cell lymphoma, nasal type (ENKL), is a rare subtype of non-Hodgkin lymphoma, and its treatment outcome was previously poor. Novel treatment strategies have improved the outcomes of ENKL remarkably in the last decade. Nowadays, patients with localized nasal ENKL are recommended treatment with concurrent chemoradiotherapy, and their 5-year overall survival rate is approximately 70%. In patients with advanced or relapsed/refractory disease, the efficacy of l-asparaginase-containing therapy has been confirmed...
April 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/28291529/nasal-type-extranodal-natural-killer-t-cell-lymphoma
#17
F Moreno-Suárez, P Bautista Martínez, F Jiménez Burgos
No abstract text is available yet for this article.
March 10, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28284718/novel-jak3-activating-mutations-in-extranodal-nk-t-cell-lymphoma-nasal-type
#18
Sung H Sim, Soyeon Kim, Tae M Kim, Yoon K Jeon, Soo J Nam, Yong-Oon Ahn, Bhumsuk Keam, Hyun H Park, Dong-Wan Kim, Chul W Kim, Dae S Heo
Inhibition of the Janus kinase (JAK)-STAT pathway has been implicated as a treatment option for extranodal natural killer/T-cell lymphoma, nasal type (NTCL). However, JAK-STAT pathway alterations in NTCL are variable, and the efficacy of JAK-STAT pathway inhibition has been poorly evaluated. JAK3 mutation and STAT3 genetic alterations were investigated by direct sequencing and immunohistochemistry in 84 patients with newly diagnosed NTCL. Five of 71 patients with NTCL (7.0%) had JAK3 mutations in the pseudokinase domain: two JAK3(A573V), two JAK3(H583Y), and one JAK3(G589D) mutation...
March 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28278074/a-clinical-study-of-21-patients-with-hemophagocytic-syndrome-in-295-cases-diagnosed-with-nasal-type-extranodal-nature-killer-t-cell-lymphoma
#19
Na Li, Li Zhang, Jie Liu, Jing Zhang, Hua-Wei Weng, Hong-Yu Zhuo, Li-Qun Zou
Nasal type, extranodal nature killer (NK)/T cell lymphoma-associated hemophagocytic syndrome (NK/T-LAHS) is a rare and fatal disorder with extremely poor prognosis. To investigate its clinical characteristics and risk factors, we retrospectively analyzed 295 patients with nasal type, extranodal nature killer/T cell lymphoma, of which 21 were diagnosed with hemophagocytic syndrome, with a cumulative incidence of 7.1%. The most frequently clinical characteristics were fever, lymphadenopathy, hepatosplenomegaly, pancytopenia, hyperferritinemia, liver dysfunction, hypertriglyceridemia, hypofibrinogenemia and evaluated lactate dehydrogenase (LDH) level...
February 25, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28275603/isolated-extranodal-natural-killer-t-cell-lymphoma-of-the-orbit-in-a-young-patient-complete-regression-with-the-smile-regimen
#20
Rachna Meel, Rebika Dhiman, Meenakshi Wadhwani, Seema Kashyap, Sanjay Sharma, Ajay Gogia
PURPOSE: Natural killer T-cell lymphoma (NKTL) is a highly malignant tumor that typically arises in the nose and/or paranasal sinuses. Isolated orbital involvement by NKTL is extremely rare, and only few case reports exist in the literature. Herein, we report a case of primary orbital NKTL in a young patient who showed very good response to chemotherapy with the SMILE regimen. METHODS: A 28-year-old healthy female presented to us with epiphora and fullness of the lower eyelid...
January 2017: Ocular Oncology and Pathology
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