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Dapagliflozin and dpp4

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https://www.readbyqxmd.com/read/28447181/sglt-2-inhibition-with-dapagliflozin-reduces-the-activation-of-the-nlrp3-asc-inflammasome-and-attenuates-the-development-of-diabetic-cardiomyopathy-in-mice-with-type-2-diabetes-further-augmentation-of-the-effects-with-saxagliptin-a-dpp4-inhibitor
#1
Yumei Ye, Mandeep Bajaj, Hsiu-Chiung Yang, Jose R Perez-Polo, Yochai Birnbaum
PURPOSE: We assessed whether (1) dapagliflozin (Dapa, an SGLT2-inhibitor) attenuates the deterioration of heart function Nlrp3 and inflammasome activation in diabetic mice. (2) The effects can be augmented with saxagliptin (Saxa), a DDP4-inhibitor. (3) Dapa effect is possibly SGLT2-independent on cardiofibroblasts in vitro. METHODS: Type 2 diabetic (BTBR ob/ob) and wild-type (WT) mice received vehicle, Dapa, or Dapa+Saxa for 8 weeks. Glucose tolerance test and echocardiogram were performed...
April 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/26533409/dapagliflozin-versus-a-dipeptidyl-peptidase-4-inhibitor-dpp4-both-added-to-metformin-in-patients-with-type-2-diabetes-mellitus-t2dm-impact-on-health-quality-of-life-and-costs-in-the-turkish-clinical-setting
#2
S Malhan, S Guler, I Yetkin, T J Ignacio, B Verheggen, M Charokopou
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/25555492/-cost-effectiveness-analysis-of-dapagliflozin-compared-to-dpp4-inhibitors-and-other-oral-antidiabetic-drugs-in-the-treatment-of-type-2-diabetes-mellitus-in-spain
#3
Eduardo José Abad Paniagua, Pedro Casado Escribano, José María Fernández Rodriguez, Francisco J Morales Escobar, Lourdes Betegón Nicolás, Joaquín Sánchez-Covisa, Max Brosa
OBJECTIVE: To assess the efficiency of the combined therapy with metformin and dapagliflozin, a new oral anti-diabetic drug with an insulin-independent mechanism of action, in the treatment of type-2 diabetes mellitus (T2DM) compared to DPP4 inhibitors, sulphonylureas and thiazolidindiones, also combined with metformin. DESIGN: Cost-effectiveness analysis using a discrete event simulation model based on the results of the available clinical trials and considering patient's entire life as time horizon...
October 2015: Atencion Primaria
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