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Dapagliflozin and sitagliptin

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https://www.readbyqxmd.com/read/27642611/effectiveness-and-safety-of-newer-antidiabetic-medications-for-ramadan-fasting-diabetic-patients
#1
REVIEW
Ehab Mudher Mikhael
Hypoglycemia is the most common side effects for most glucose-lowering therapies. It constitutes a serious risk that faces diabetic patients who fast during Ramadan (the 9th month in the Islamic calendar). New glucose-lowering classes like dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 receptor agonist (GLP-1 RA), and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are efficacious in controlling blood glucose level with less tendency to induce hypoglycemia and thus may constitute a good choice for diabetic patients during Ramadan...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27356271/comparative-persistence-and-adherence-with-newer-anti-hyperglycemic-agents-to-treat-patients-with-type-2-diabetes-in-the-united-states
#2
Jennifer Cai, Yuexi Wang, Onur Baser, Lin Xie, Wing Chow
OBJECTIVES: Non-adherence and non-persistence to anti-hyperglycemic agents are associated with worse clinical and economic outcomes in patients with type 2 diabetes. This study evaluated treatment persistence and adherence across newer anti-hyperglycemic agents (canagliflozin, dapagliflozin, sitagliptin, saxagliptin, linagliptin, liraglutide, or exenatide). METHODS: This retrospective cohort study of Truven Health Analytics Marketscan databases included adult patients with type 2 diabetes whose first pharmacy claim for a newer anti-hyperglycemic agent was between February 1, 2014 and July 31, 2014...
July 12, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/26824365/novel-therapeutic-approaches-in-diabetes
#3
REVIEW
Baptist Gallwitz
This chapter deals with novel therapeutic approaches, predominantly for type 2 diabetes. Incretin-based therapies utilize the effects of glucagon-like peptide-1 (GLP-1), which stimulates insulin and inhibits glucagon secretion in a glucose-dependent manner. Incretin-based therapies comprise injectable GLP-1 receptor agonists and orally active dipeptidyl peptidase-IV inhibitors. Both have a low hypoglycaemia risk. GLP-1 receptor agonists (exenatide, liraglutide, lixisenatide, dulaglutide, albiglutide) reduce glycated haemoglobin levels more effectively than oral antidiabetic agents do and lead to weight loss as well as a slight decrease in systolic blood pressure...
2016: Endocrine Development
https://www.readbyqxmd.com/read/26513131/sglt2-inhibition-efficacy-and-safety-in-type-2-diabetes-treatment
#4
REVIEW
André J Scheen
INTRODUCTION: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) offer a new opportunity for the management of type 2 diabetes mellitus. These agents reduce hyperglycemia by decreasing the renal glucose threshold and thereby increasing urinary glucose excretion. Subsequent reduction of glucotoxicity improves beta-cell sensitivity to glucose and tissue insulin sensitivity. AREAS COVERED: This article analyzes the efficacy and safety data of canagliflozin, dapagliflozin and empagliflozin in randomized controlled trials of 24 - 104 weeks duration, compared with placebo or an active comparator, in patients treated with diet/exercise, metformin, dual oral therapy or insulin...
2015: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/26381272/comparative-efficacy-of-anti-diabetic-agents-on-nonalcoholic-fatty-liver-disease-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-and-non-randomized-studies
#5
REVIEW
Wenjuan Tang, Qianyue Xu, Ting Hong, Guoyu Tong, Wenhuan Feng, Shanmei Shen, Yan Bi, Dalong Zhu
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in patients with type 2 diabetes mellitus (T2DM). In this study, we sought to provide a comprehensive assessment regarding the effects of anti-diabetic agents on NAFLD in patients with T2DM. METHODS: MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) with different anti-diabetic agents in T2DM. Observational trials were also recruited to expand our population...
February 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/25694411/dapagliflozin-a-new-sodium-glucose-cotransporter-2-inhibitor-for-treatment-of-type-2-diabetes
#6
REVIEW
Eva M Vivian
PURPOSE: The pharmacologic properties and clinical efficacy of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes, are reviewed. SUMMARY: Dapagliflozin (Farxiga, AstraZeneca) is a selective SGLT2 inhibitor approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Dapagliflozin lowers blood glucose independent of insulin secretion and action by inhibiting renal reabsorption of glucose, thus promoting increased urinary excretion of glucose...
March 1, 2015: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/25488697/pharmacodynamics-efficacy-and-safety-of-sodium-glucose-co-transporter-type-2-sglt2-inhibitors-for-the-treatment-of-type-2-diabetes-mellitus
#7
REVIEW
André J Scheen
Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries (dapagliflozin, canagliflozin, empagliflozin and ipragliflozin) and some others are in a late phase of development. The available SGLT2 inhibitors share similar pharmacokinetic characteristics, with a rapid oral absorption, a long elimination half-life allowing once-daily administration, an extensive hepatic metabolism mainly via glucuronidation to inactive metabolites, the absence of clinically relevant drug-drug interactions and a low renal elimination as parent drug...
January 2015: Drugs
https://www.readbyqxmd.com/read/24998153/dapagliflozin-do-we-need-it-registered-for-type-2-diabetes
#8
COMMENT
Sheila A Doggrell, Rinku Tuli
INTRODUCTION: Inhibitors of the sodium-glucose co-transporter 2 (SGLT2) promote the excretion of glucose to reduce glycated hemoglobin (HbA1c) levels. Canagliflozin was the first SGLT2 inhibitor to be approved by the US FDA for use in the treatment of type 2 diabetes, and recently dapagliflozin has also been approved. AREAS COVERED: We evaluated a recent Phase III clinical trial with dapagliflozin. EXPERT OPINION: Dapagliflozin was studied as add-on therapy to sitagliptin with or without metformin, and was shown to lower HbA1c levels and body weight...
August 2014: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/24951310/dapagliflozin-for-the-treatment-of-type-2-diabetes-mellitus
#9
REVIEW
Andrew Aylsworth, Zachary Dean, Cody VanNorman, Arinze Nkemdirim Okere
OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical trials, and adverse effects of dapagliflozin, a sodium glucose co-transporter 2 (SGLT-2) inhibitor. DATA SOURCES: Data were gathered from articles indexed in PubMed, International Pharmaceutical from (2006 to April 2014) was performed using the following terms "dapagliflozin," "SGLT-2 inhibitor," and "Farxiga." Abstracts and manufacturer's package insert were also used as an additional reference. STUDY SELECTION AND DATA EXTRACTION: All English language prospective randomized, double-blinded trials evaluating the efficacy of dapagliflozin for the treatment of type 2 diabetes were identified...
September 2014: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/24148209/composite-endpoints-in-trials-of-type-2-diabetes
#10
REVIEW
T R Einarson, M Garg, V Kaur, M E H Hemels
Composite endpoints (CEPs) are being used more frequently as outcomes for trials of drugs in type-2 diabetes. We reviewed the literature to determine how CEPs have been used to date in trials of drugs for type-2 diabetes. A systematic search was undertaken on Medline, Embase and Cochrane databases and Clinicaltrials.gov for randomized controlled trials of currently marketed agents including SGLT-2 inhibitors (dapagliflozin), GLP-1 agonists (exenatide, liraglutide) and DPP-4 inhibitors (linagliptin, saxagliptin, sitagliptin and vildagliptin)...
June 2014: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/24144654/dapagliflozin-is-effective-as-add-on-therapy-to-sitagliptin-with-or-without-metformin-a-24-week-multicenter-randomized-double-blind-placebo-controlled-study
#11
RANDOMIZED CONTROLLED TRIAL
Serge A Jabbour, Elise Hardy, Jennifer Sugg, Shamik Parikh
OBJECTIVE: To assess the efficacy and safety of dapagliflozin as add-on therapy in patients with type 2 diabetes who were inadequately controlled with a dipeptidyl peptidase-4 inhibitor with or without metformin. RESEARCH DESIGN AND METHODS: In this 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 study with a 24-week blinded extension period, 432 patients were randomized to receive dapagliflozin 10 mg/day or placebo added to sitagliptin (100 mg/day) ± metformin (≥1,500 mg/day)...
2014: Diabetes Care
https://www.readbyqxmd.com/read/23087012/systematic-review-of-sglt2-receptor-inhibitors-in-dual-or-triple-therapy-in-type-2-diabetes
#12
Christine Clar, James Alexander Gill, Rachel Court, Norman Waugh
BACKGROUND: Despite the number of medications for type 2 diabetes, many people with the condition do not achieve good glycaemic control. Some existing glucose-lowering agents have adverse effects such as weight gain or hypoglycaemia. Type 2 diabetes tends to be a progressive disease, and most patients require treatment with combinations of glucose-lowering agents. The sodium glucose co-transporter 2 (SGLT2) receptor inhibitors are a new class of glucose-lowering agents. OBJECTIVE: To assess the clinical effectiveness and safety of the SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes...
2012: BMJ Open
https://www.readbyqxmd.com/read/21114603/lack-of-pharmacokinetic-interaction-between-dapagliflozin-a-novel-sodium-glucose-transporter-2-inhibitor-and-metformin-pioglitazone-glimepiride-or-sitagliptin-in-healthy-subjects
#13
RANDOMIZED CONTROLLED TRIAL
S Kasichayanula, X Liu, W C Shyu, W Zhang, M Pfister, S C Griffen, T Li, F P LaCreta, D W Boulton
AIMS: Dapagliflozin increases urinary glucose excretion by selectively inhibiting renal sodium-glucose transporter 2, an insulin-independent mechanism of action that may be complementary to that of other oral antidiabetes drugs. The current studies assessed the potential for pharmacokinetic (PK) interaction between dapagliflozin and pioglitazone, metformin, glimepiride or sitagliptin in healthy subjects following single-dose administration. METHODS: In open-label, randomized, three-period, three-treatment crossover studies, 24 subjects received 50 mg dapagliflozin, 45 mg pioglitazone or the combination, while 18 subjects received 20 mg dapagliflozin, 1000 mg metformin or the combination...
January 2011: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/20878582/american-chemical-society-240th-national-meeting-chemistry-for-preventing-and-combating-disease-part-1
#14
Jessica Burt
The 240th National Meeting of the American Chemical Society, held in Boston, included topics covering new therapeutic research. This conference report highlights selected presentations on negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) for the treatment of Parkinson's disease, BACE1 inhibitors and γ-secretase inhibitors for the prevention or treatment of Alzheimer's disease, opioid modulators for the treatment of reward disorders, SGLT2 inhibitors for the treatment of diabetes, backup compounds to the DPP-4 inhibitor sitagliptin (Januvia) for type 2 diabetes, and MCH R1 inhibitors for the treatment of obesity...
October 2010: IDrugs: the Investigational Drugs Journal
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