keyword
https://read.qxmd.com/read/38402502/effects-of-sodium-glucose-co-transporter-2-inhibitors-on-ultrafiltration-in-patients-with-peritoneal-dialysis-a-protocol-for-a-randomized-double-blind-placebo-controlled-crossover-trial-empowered
#21
JOURNAL ARTICLE
Yohei Doi, Maki Shinzawa, Tetsuya Arisato, Hideaki Oka, Ayumi Matsumoto, Harumi Kitamura, Yumi Nakazono, Yoichi Nishiya, Yoshiyasu Ueda, Taro Kamimura, Terumasa Hayashi, Fumiki Yoshihara, Yoshitaka Isaka
BACKGROUND: Volume overload is common and associated with high mortality in patients on peritoneal dialysis (PD). Traditional strategies including diuretics, water/salt restriction, and icodextrin-based solutions cannot always fully correct this condition, necessitating novel alternative strategies. Recent studies confirmed the expression of sodium-glucose cotransporter 2 (SGLT2) in the human peritoneum. Experimental data suggest that SGLT2 inhibitors decrease glucose absorption from the PD solution, thereby increasing the ultrafiltration volume...
February 25, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38401652/classification-of-the-urgency-of-the-procedure-and-outcome-of-acute-type-a-aortic-dissection
#22
JOURNAL ARTICLE
Fausto Biancari, Angelo M Dell'Aquila, Francesco Onorati, Cecilia Rossetti, Till Demal, Andreas Rukosujew, Sven Peterss, Joscha Buech, Antonio Fiore, Thierry Folliguet, Andrea Perrotti, Amélie Hervé, Francesco Nappi, Lenard Conradi, Angel G Pinto, Javier Rodriguez Lega, Marek Pol, Petr Kacer, Konrad Wisniewski, Enzo Mazzaro, Giuseppe Gatti, Igor Vendramin, Daniela Piani, Luisa Ferrante, Mauro Rinaldi, Eduard Quintana, Robert Pruna-Guillen, Sebastien Gerelli, Dario Di Perna, Metesh Acharya, Giovanni Mariscalco, Mark Field, Manoj Kuduvalli, Matteo Pettinari, Stefano Rosato, Caius Mustonen, Tuomas Kiviniemi, Charles S Roberts, Timo Mäkikallio, Tatu Juvonen
Surgery for type A aortic dissection (TAAD) is associated with high risk of early mortality. The prognostic impact of a new classification of the urgency of the procedure was evaluated in this multicenter cohort study. Data on consecutive patients who underwent surgery for acute TAAD were retrospectively collected in the multicenter, retrospective European Registry of TAAD (ERTAAD). The rates of in-hospital mortality of 3902 consecutive patients increased along with the ERTAAD procedure urgency grades: urgent procedure, 10...
February 22, 2024: American Journal of Cardiology
https://read.qxmd.com/read/38398488/do-implantable-cardioverter-defibrillators-prevent-sudden-cardiac-death-in-end-stage-renal-disease-patients-on-dialysis
#23
REVIEW
Beata Franczyk, Jacek Rysz, Robert Olszewski, Anna Gluba-Sagr
Chronic kidney disease patients appear to be predisposed to heart rhythm disorders, including atrial fibrillation/atrial flutter, ventricular arrhythmias, and supraventricular tachycardias, which increase the risk of sudden cardiac death. The pathophysiological factors underlying arrhythmia and sudden cardiac death in patients with end-stage renal disease are unique and include timing and frequency of dialysis and dialysate composition, vulnerable myocardium, and acute proarrhythmic factors triggering asystole...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38396869/on-whether-ca-125-is-the-answer-for-diagnosing-overhydration-particularly-in-end-stage-kidney-disease-patients-a-systematic-review
#24
REVIEW
Barbara Emilia Nikitiuk, Alicja Rydzewska-Rosołowska, Katarzyna Kakareko, Irena Głowińska, Tomasz Hryszko
Overhydration (OH) is a prevalent medical problem that occurs in patients with kidney failure, but a specific marker has still not been found. Patients requiring kidney replacement therapy suffer from a water imbalance, which is correlated with mortality rates in this population. Currently, clinicians employ techniques such as bioimpedance spectroscopy (BIS) and ultrasound (USG) markers of overhydration or markers of heart and kidney function, namely NT-pro-BNP, GFR, or creatinine levels. New serum markers, including but not limited to Ca-125, galectin-3 (Gal-3), adrenomedullin (AMD), and urocortin-2 (UCN-2), are presently under research and have displayed promising results...
February 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38389780/acute-type-a-aortic-syndromes-outcomes-are-independent-of-aortic-root-valve-management
#25
JOURNAL ARTICLE
Parth Mukund Patel, Oreoluwa Elizabeth Olakunle, Andy Dong, Edward Chiou, Jane Wei, Jose Binongo, Bradley Leshnower, Edward Po Chen
PURPOSE: Clinical outcomes following various surgical intervention strategies for aortic root and valve pathology during repair of acute type A aortic syndromes were studied and compared. METHODS: From 2004 to 2019, 634 patients underwent acute type A aortic repair. Patients were divided into 4 groups: Valve Resuspension ( n  = 456), Isolated Valve Replacement (AVR) ( n  = 24), Valve and Root Replacement (ROOT) ( n  = 97), and Valve Sparing Root Replacement (VSRR) ( n  = 57)...
March 2024: Indian Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38383961/daprodustat-and-heart-failure-in-ckd
#26
JOURNAL ARTICLE
Jonathan W Cunningham, Brian L Claggett, Renato D Lopes, John J V McMurray, Vlado Perkovic, Kevin Carroll, Thomas Hiemstra, Kaivan Khavandi, Mary Ann Lukas, Prerna Ranganathan, Jennifer Shannon, Janet van Adelsberg, Ajay K Singh, Scott D Solomon
BACKGROUND: Patients with chronic kidney disease (CKD) are at higher risk for heart failure. The hypoxia inducible factor prolyl hydroxylase inhibitor daprodustat is an orally acting alternative to conventional injectable erythropoietin-stimulating agents (ESA) for the treatment of anemia in patients with CKD. Whether daprodustat affects the risk of heart failure hospitalization is unknown. METHODS: The ASCEND-D (n=2,964) and ASCEND-ND (n=3,872) trials compared daprodustat to conventional ESA in patients with anemia of CKD who did or did not require dialysis, respectively...
February 22, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38383674/subcutaneous-cardioverter-defibrillator-implanted-intermuscularly-in-patients-with-end-stage-renal-disease-requiring-hemodialysis-5-year-follow-up
#27
JOURNAL ARTICLE
Axel Kloppe, Joachim Winter, Magnus Prull, Assem Aweimer, Ibrahim El-Battrawy, Christoph Hanefeld, Stephen O'Connor, Andreas Mügge, Fabian Schiedat
BACKGROUND: The aim of the present study was to evaluate the long-term safety and effectiveness of the subcutaneous implantable cardioverter defibrillator (S-ICD) when implanted intermuscularly in patients with end-stage renal disease and hemodialysis. METHODS: This study is a retrospective analysis of 21 consecutive patients implanted with S-ICDs at three experienced centers in Germany with comorbid renal insufficiency requiring hemodialysis, as well as being at risk of sudden cardiac death...
February 22, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/38373718/risk-factor-analysis-for-30-day-mortality-after-surgery-for-infective-endocarditis
#28
JOURNAL ARTICLE
Jill Jussli-Melchers, Christine Friedrich, Kira Mandler, Mohamad Hosam Alosh, Mohamed Ahmed Salem, Jan Schoettler, Jochen Cremer, Assad Haneya
BACKGROUND:  Infective endocarditis (IE) remains a challenging disease associated with high mortality. Several scores have been suggested to assess surgical risk. None was sufficiently adequate. We therefore analyzed risk factors for 30-day mortality. METHODS:  A total of 438 consecutive patients had surgery for IE in our department between 2002 and 2020. Patients were divided into two groups, one consisting of 30-day survivors (362 patients; 82.6%) and one of nonsurvivors (76 patients; 17...
February 19, 2024: Thoracic and Cardiovascular Surgeon
https://read.qxmd.com/read/38369359/pure-red-cell-aplasia-secondary-to-parvovirus-b19-infection-as-a-rare-cause-of-anemia-in-a-dialysis-patient-a-case-report
#29
JOURNAL ARTICLE
Yuequan Shi, Xiaoxiao Shi, Haiyun Wang, Zijuan Zhou, Lei Zhang, Limeng Chen
Parvovirus B19 infection can cause chronic pure red cell aplasia in immunosuppressed hosts or acute and transient aplastic crises in immunocompetent hosts. In dialysis patients, only transient aplastic crisis induced by parvovirus B19 infection has been reported. We herein report the first case of an adult dialysis patient who developed chronic pure red cell aplasia associated with parvovirus B19 infection. Repeated pneumonia and heart failure may contribute to an immunocompromised status, making the patient more vulnerable to parvovirus B19 infection...
February 19, 2024: Internal Medicine
https://read.qxmd.com/read/38360191/morbidity-and-mortality-of-common-femoral-endarterectomy
#30
JOURNAL ARTICLE
Michael Chaney, Gaurang Joshi, Jose Cataneo Serrato, Mohammad Rashid, Abraham Jacobs, Chad E Jacobs, John V White, Lewis B Schwartz, Rym El Khoury
OBJECTIVE: Common femoral endarterectomy (CFE) comprises the current standard-of-care for symptomatic common femoral artery (CFA) occlusive disease. While it provides effective inflow revascularization via a single incision, it remains an invasive procedure in an often-frail patient population. The purpose of this retrospective clinical study was to assess the morbidity and mortality of CFE in a contemporary cohort. METHODS: Consecutive CFEs performed at a large, urban hospital were reviewed...
February 13, 2024: Journal of Vascular Surgery
https://read.qxmd.com/read/38360102/long-term-changes-in-cardiac-remodelling-in-prevalent-kidney-graft-recipients
#31
JOURNAL ARTICLE
V Panisset, N Girerd, E Bozec, Z Lamiral, Q d'Herve, L Frimat, S Girerd
BACKGROUND: Approximately 15% of kidney transplant (KT) recipients develop de novo heart failure after KT. There are scarce data reporting the long-term changes in cardiac structure and function among KT recipients. Despite the improvement in renal function, transplant-related complications as well as immunosuppressive therapy could have an impact on cardiac remodelling during follow-up. We aimed to describe the long-term changes in echocardiographic parameters in prevalent KT recipients and identify the clinical and laboratory factors associated with these changes...
February 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38336724/determinants-of-survival-following-heart-transplantation-in-adults-with-congenital-heart-disease
#32
REVIEW
Hüseyin Sicim, Pierre Emmanuel Noly, Suyash Naik, Vikram Sood, Richard G Ohye, Jonathan W Haft, Keith D Aaronson, Francis D Pagani, Ming-Sing Si, Paul C Tang
BACKGROUND: Adult patients surviving with congenital heart disease (ACHD) is growing. We examine the factors associated with heart transplant outcomes in this challenging population with complex anatomy requiring redo-surgeries. METHODS: We reviewed the United Network for Organ Sharing-Standard Transplant Analysis and Research database and analyzed 35,952 heart transplants from January 1st, 2000, to September 30th, 2018. We compared transplant characteristics for ischemic cardiomyopathy (ICM) (n = 14,236), nonischemic cardiomyopathy (NICM) (n = 20,676), and ACHD (n = 1040)...
February 10, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38331252/vaccination-and-the-risk-of-post-acute-sequelae-after-covid-19-in-the-omicron-predominant-period
#33
JOURNAL ARTICLE
Kyungmin Huh, Young-Eun Kim, Gi Hwan Bae, Jong Youn Moon, Ji-Man Kang, Jacob Lee, Jang-Whan Bae, Kyong Ran Peck, Jaehun Jung
OBJECTIVES: To assess the association of primary and third doses of vaccination with the risk of post-acute sequelae of COVID-19. METHODS: This retrospective cohort study utilized a combined database of nationwide healthcare claims data, COVID-19 patient registry, and vaccination records from South Korea. Individuals diagnosed with COVID-19 in the Omicron variant-dominant period of January to March 2022 were tracked for 30-120 days post-infection. The exposure of interest was the receipt of primary and third doses of the SARS-CoV-2 vaccine...
February 6, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38330042/safety-of-hyperbaric-oxygen-therapy-in-patients-with-heart-failure-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Simone Schiavo, Connor T A Brenna, Lisa Albertini, George Djaiani, Anton Marinov, Rita Katznelson
BACKGROUND: Hyperbaric oxygen therapy (HBOT) has several hemodynamic effects including increases in afterload (due to vasoconstriction) and decreases in cardiac output. This, along with rare reports of pulmonary edema during emergency treatment, has led providers to consider HBOT relatively contraindicated in patients with reduced left ventricular ejection fraction (LVEF). However, there is limited evidence regarding the safety of elective HBOT in patients with heart failure (HF), and no existing reports of complications among patients with HF and preserved LVEF...
2024: PloS One
https://read.qxmd.com/read/38323492/how-do-sglt2-inhibitors-protect-the-kidney-a-mediation-analysis-of-the-empa-reg-outcome-trial
#35
JOURNAL ARTICLE
Christoph Wanner, Masaomi Nangaku, Bettina J Kraus, Bernard Zinman, Michaela Mattheus, Stefan Hantel, Martin Schumacher, Kristin Ohneberg, Claudia Schmoor, Silvio E Inzucchi
INTRODUCTION: Mechanisms underlying kidney benefits with sodium-glucose cotransporter-2 (SGLT2) inhibition in heart failure and/or type 2 diabetes (T2D) with established cardiovascular disease are currently unclear. METHODS: We evaluated post hoc the factors mediating the effect of empagliflozin on a composite kidney outcome (first sustained estimate glomerular filtration rate ≥40% reduction from baseline, initiation of renal replacement therapy, or death due to kidney disease) in EMPA-REG OUTCOME...
February 6, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38319325/circulating-osteoprotegerin-as-a-cardiac-biomarker-for-left-ventricular-diastolic-dysfunction-in-patients-with-pre-dialysis-chronic-kidney-disease-the-know-ckd-study
#36
JOURNAL ARTICLE
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Ji Yong Jung, Young Youl Hyun, Soo Wan Kim
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major cause of mortality in patients with chronic kidney disease (CKD), and diagnosis is challenging. Moreover, no specific biomarker for HFpEF has been validated in patients with CKD. The present study aimed to investigate the association between serum osteoprotegerin (OPG) levels and the risk of left ventricular diastolic dysfunction (LVDD), a surrogate of HFpEF, in patients with pre-dialysis CKD. METHODS: A total of 2039 patients with CKD at stage 1 to pre-dialysis 5 were categorized into quartiles (Q1 to Q4) by serum OPG levels, and were cross-sectionally analyzed...
February 6, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38313918/cardiac-magnetic-resonance-imaging-findings-in-patients-with-chronic-kidney-disease-and-end-stage-kidney-disease-a-systematic-review-and-meta-analysis
#37
REVIEW
Deepak Chandramohan, Rhoshini Rajasekaran, Raghunandan Konda, Ashwini Pujari, Sreekant Avula, Megan Bell, Sujith K Palleti, Apoorv Deotare, Roopa Naik, Atul Bali, Prathap Simhadri, Harkesh Arora, Nihar Jena
In this systematic review and meta-analysis, we explored the utilization of cardiac magnetic resonance imaging (CMR) to detect fibrotic changes secondary to uremic cardiomyopathy during the early stages of chronic kidney disease (CKD) and in patients with end-stage kidney disease (ESKD). Uremic myocardial fibrosis can lead to arrhythmia and heart failure, and it is important to detect these changes. CMR offers a noninvasive way to characterize the severity of cardiac remodeling. A comprehensive search of multiple electronic databases was conducted...
January 2024: Curēus
https://read.qxmd.com/read/38312794/systematic-review-of-cardiovascular-benefits-and-safety-of-sacubitril-valsartan-in-end-stage-kidney-disease
#38
JOURNAL ARTICLE
Mariam Charkviani, Pajaree Krisanapan, Charat Thongprayoon, Iasmina M Craici, Wisit Cheungpasitporn
INTRODUCTION: Patients with end-stage kidney disease (ESKD) frequently develop heart failure, contributing to high mortality. Limited data exist on cardiovascular benefits and safety of sacubitril-valsartan in this population. Our systematic review aims to evaluate the efficacy and safety of sacubitril-valsartan versus standard care in patients with ESKD who are on dialysis. METHODS: We conducted a search in Embase, MEDLINE, and Cochrane databases to identify relevant studies and assessed outcomes using random-effect model and generic inverse variance approach...
January 2024: KI Reports
https://read.qxmd.com/read/38297433/cardiovascular-outcomes-in-home-hemodialysis-and-peritoneal-dialysis-patients
#39
JOURNAL ARTICLE
Silvi Shah, Eric Weinhandl, Nupur Gupta, Anthony C Leonard, Annette L Christianson, Charuhas V Thakar
BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage kidney disease. Little is known about differences in cardiovascular outcomes between home hemodialysis (HHD) and peritoneal dialysis (PD). METHODS: We evaluated 68,645 patients who initiated home dialysis between 1/1/2005 and 12/31/2018 using the United States Renal Data System with linked Medicare claims. Rates for incident cardiovascular events of acute coronary syndrome, heart failure, and stroke hospitalizations were determined...
February 1, 2024: Kidney360
https://read.qxmd.com/read/38296804/safety-and-efficacy-of-colchicine-in-crystal-induced-arthritis-flare-in-54-patients-with-severe-chronic-kidney-disease
#40
JOURNAL ARTICLE
Johanna Bausson, Nicolas Keller, Jean-Jacques Von Hunolstein, Matthieu Sacrez, Bruno Michel, Bénédicte Gourieux, Marion Fourtage, Renaud Felten
INTRODUCTION: Colchicine, commonly used in gout flare, is contraindicated in severe chronic kidney disease (CKD) (estimated glomerular filtration rate <30 mL/min). However, in this context, there are few alternatives, and colchicine use persists. We evaluated the tolerance of colchicine and its efficacy in patients with severe CKD. PATIENTS AND METHODS: All prescriptions of colchicine for managing crystal-induced arthritis flare (gout or calcium pyrophosphate deposition (CPPD) disease) in a hospitalised patient with severe CKD were screened from September 2020 to September 2021...
January 31, 2024: RMD Open
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