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Basal cell carcinoma

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https://www.readbyqxmd.com/read/28550085/knockdown-of-sodium-calcium-exchanger-1-induces-epithelial-to-mesenchymal-transition-in-kidney-epithelial-cells
#1
Sona Lakshme Balasubramaniam, Anilkumar Gopalakrishnapillai, Nicholas J Petrelli, Sonali P Barwe
Mesenchymal to epithelial transition (MET) and epithelial to mesenchymal transition (EMT) are important processes in kidney development. Failure to undergo MET during development leads to the initiation of Wilms tumor (WT) whereas EMT contributes to the development of renal cell carcinomas (RCC). The role of calcium regulators in governing these processes is becoming evident. We demonstrated earlier that Na+/Ca2+ exchanger 1 (NCX1), a major calcium exporter in renal epithelial cells, regulates epithelial cell motility...
May 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28549423/glyoxalase-1-expression-is-associated-with-an-unfavorable-prognosis-of-oropharyngeal-squamous-cell-carcinoma
#2
Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess, Karim Zaoui
BACKGROUND: Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulation and clinical relevance of Glyoxalase 1 in the context of head and neck squamous cell carcinoma has not been addressed so far. METHODS: Argpyrimidine modification as a surrogate for methylglyoxal accumulation and Glyoxalase 1 expression in tumor cells was assessed by immunohistochemical staining of tissue microarrays with specimens from oropharyngeal squamous cell carcinoma patients (n = 154)...
May 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28549030/p40-immunostain-does-not-outperform-p63-as-a-myoepithelial-cell-marker-in-the-daily-practice-of-breast-pathology
#3
Laila Khazai, Emmanuel Agosto-Arroyo, Marilin Rosa
P40 antibody has been shown to be a more specific squamous and basal cell marker compared with p63. As detection of myoepithelial cells (MECs) plays a critical role in breast pathology, and the fact that p40 targets an isoform of p63, this study was designed to compare these antibodies in a variety of lesions, especially those with an sclerotic stroma and carcinoma in situ. All studied lesions were selected from the daily cases of the 3 authors and stained with p63, p40, and calponin immunohistochemical stains...
May 25, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28548901/neuroendocrine-differentiation-in-basal-cell-carcinoma
#4
Yoldez Houcine, Ines Chelly, Alia Zehani, Linda Belhaj Kacem, Haifa Azzouz, Wafa Rekik, Hend C, Slim Haouet, Nidhameddine Kchir
Basal cell carcinoma (BCC) is the prototypical basaloid tumour of the skin. It may show various patterns simulating other cutaneous tumours due to its pleomorphism. It may have unusal pattern of differentiaton such as squamous, sebaceous, apocrine, eccrine, pilar and endocrine differentiation. In order to establish the relative frequency of neuroendocrine differentiation in BCC, we performed a retrospective study of 33 consecutive BCCs using conventional immunohistochemistry with two neuroendocrine antibodies: Chromogranine A and synaptophysine...
May 26, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28546761/spotlight-on-vismodegib-in-the-treatment-of-basal-cell-carcinoma-an-evidence-based-review-of-its-place-in-therapy
#5
REVIEW
Zoe Apalla, Chrysoula Papageorgiou, Aimilios Lallas, Elena Sotiriou, Elizabeth Lazaridou, Efstratios Vakirlis, Athanassios Kyrgidis, Demetrios Ioannides
Vismodegib is approved for the treatment of adult patients with metastatic (mBCC) or locally advanced basal cell carcinoma (laBCC) that have recurred following surgery or for those who are not good candidates for surgery (risk/benefit ratio is against patient's benefit, either because of the general condition or because of the expected morbidity from the surgery) or radiation therapy. This article provides an evidence-based review of its current place in therapy. Analytically, the clinical implications in the management of laBCCs and mBCCs and possible new indications, including the neoadjuvant use before surgical excision, are discussed, while in the end, the challenges regarding class-related adverse events and their optimal management are highlighted...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28544044/carcinoma-ex-basal-cell-adenoma-of-the-parotid-gland-a-report-of-an-extremely-rare-case
#6
Kimihide Kusafuka, Takuya Kawasaki, Takashi Nakajima, Takashi Sugino
Malignant non-basaloid tumors that arise from basal cell adenoma (BCA) are extremely rare. The patient was a 72-year-old Japanese male, who had noticed swelling of the left parotid region 21 years ago. A superficial lobectomy was performed. About 60% of the tumor was made up of cribriform and trabecular tissue composed of basaloid cells, which exhibited mild atypia and nuclear expression of β-catenin. This portion of the tumor was considered to be a BCA. In the other part of the tumor, the proliferation of large eosinophilic atypical cells, most of which formed intraductal structures, was observed...
May 19, 2017: Pathology International
https://www.readbyqxmd.com/read/28543586/multiple-skin-cancers-in-patients-with-mycosis-fungoides-after-long-term-ultraviolet-phototherapy
#7
K Imafuku, H Hata, T Yanagi, S Kitamura, Y Inamura-Takashima, M Nishimura, S Kitamura, S Moriwaki, H Shimizu
Phototherapy is a useful noninvasive therapy, but it can induce cutaneous malignant tumours, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). We report on a 79-year-old man who had long-standing mycosis fungoides for 40 years, which had been treated with psoralen ultraviolet A therapy for 37 years at a dose of approximately 5000 J/cm(2) . Approximately 6 years before presentation, numerous types of cutaneous malignancies, including actinic keratosis, BCC and SCC, had begun to develop all over the patient's body...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28543532/intraepidermal-merkel-cell-carcinoma-a-case-series-of-a-rare-entity-with-clinical-follow-up
#8
George Jour, Phyu P Aung, Eduardo Rozas-Muñoz, Johnathan L Curry, Victor Prieto, Doina Ivan
BACKGROUND: Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous carcinoma. MCC involves typically dermis and although epidermotropism has been reported, MCC strictly intraepidermal or in situ (MCCIS) is exceedingly rare. Most of the cases of MCCIS described so far have associated other lesions, such as squamous or basal cell carcinoma, actinic keratosis, etc. Herein, we describe three patients with MCC strictly in situ, without a dermal component. METHODS: Our patients were elderly, two of the lesions involved the head and neck area and one was on a finger...
May 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28541884/an-incomplete-picture-challenges-of-partial-biopsies-in-large-diameter-atypical-melanocytic-lesions
#9
Lauren C Strazzulla, Hong Wu, Marissa Heller, Caroline C Kim
Large diameter atypical pigmented lesions (LDAPL) can be challenging to diagnose accurately using partial biopsies because of pathologic heterogeneity, while at the same time large excisions of these lesions confer significant morbidity to patients. Consequently, clinicians are often challenged by the management of these lesions. In this case, we describe an elderly patient with a history of multiple basal cell carcinomas, prior melanomas, and a family history of melanoma who presented with an irregularly pigmented brown and dark brown patch on his upper back...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28538884/evaluation-of-surgical-margins-according-to-the-histological-type-of-basal-cell-carcinoma
#10
Charles Antonio Pires de Godoy, Alice Lima de Oliveira Neta, Sofia Silveira de Souza Leão, Raul Lima Dantas, Valeska Oliveira Fonseca Carvalho, Samuel Freire da Silva
Basal cell carcinoma is the most common skin cancer in the world. The aim of this study was to evaluate the surgical margin of basal cell carcinoma and correlate this with its histologic subtype. A retrospective analysis of pathology laboratory records from 1990 to 2000 was performed and the following data was collected: age, sex, race, anatomical location, histological type, and state of the excision margins in 1,428 histopathological reports of basal cell carcinoma. Ages ranged from 6 to 99 years, with an average of 57...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538028/unnecessary-cost-of-post-mohs-permanent-pathology
#11
Kelly M MacArthur, Nikki Tang, George J Hruza, Timothy S Wang, Robert G Egbers
BACKGROUND: By providing tumor-free margins, Mohs micrographic surgery (MMS) results in high cure rates in the treatment of nonmelanoma skin cancers (NMSCs). However, when closure of the post-MMS defect is coordinated with reconstructive surgery, redundant tissue is sometimes submitted for permanent section evaluation. OBJECTIVE: The purpose of our study was to investigate the frequency and effect of this practice. MATERIALS AND METHODS: Patients (12 years and older) with NMSCs cleared by MMS with coordinated closures from 2014 to 2016 were identified...
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28537867/basaloid-follicular-hamartoma-clinical-dermoscopic-and-histopathological-characteristics-of-case
#12
Ellie Choi, May Liau, Jingxiang Huang, Kong Bing Tan, Derrick Aw
Basaloid follicular hamartoma (BFH) is a rare benign adnexal tumor with variable clinical presentation. We report a case of a 64-year-old man, who presented with an incidental finding of a 3mm hyperpigmented macule on his cheek. Dermoscopy revealed a structureless blue lesion. Histopathology examination showed interconnecting lobules and cords of bland pigmented epithelial cells within the dermal stroma, with the presence of pseudohorncysts. The lesional cells were faintly positive for Bcl2on immunohistochemical staining...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28530256/can-the-onset-of-orbital-cancer-be-the-result-of-a-prosthetic-eye
#13
A Croce, V Mastronardi, M Laus, E Festa Kotelnikova
Orbital exenteration is a disfiguring procedure performed for unresponsive orbital infections and control of recurrent benign tumours and malignancies arising from the eyelids (basal cell carcinoma, squamous cell carcinoma, conjunctival malignant melanoma), lachrymal glands (adenoid cystic carcinoma) or surrounding sinuses. In extremely rare cases the use of a prosthetic eye after enucleation can lead to anophthalmic socket tumours. We report the case of a 54-year-old man who had left eye enucleation due to recurring events of retinal detachment and who developed an invasive fast growing epidermoid carcinoma 30 years later...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28529599/snail-homolog-1-is-involved-in-epithelial-mesenchymal-transition-like-processes-in-human-glioblastoma-cells
#14
Caspar D Kühnöl, Carina Würfel, Martin S Staege, Christof Kramm
Despite advancements in neurosurgery, chemotherapy and radiation therapy, the outcome of patients with glioblastoma remains poor. The migration of tumor cells from the primary tumor site with subsequent invasion of these cells into the surrounding normal brain tissue is frequently responsible for relapse and treatment failure. The present study hypothesized that snail homolog 1 (SNAI1), a factor critically involved in the epithelial-mesenchymal transition (EMT) of human carcinoma cells, may also contribute to an invasive EMT-like phenotype of glioblastoma cells...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529425/reconstruction-with-dorsal-nasal-flap-after-excision-of-basal-cell-carcinoma-of-the-nose
#15
Amitabh Jena, Revanth Gangasani, Naru Ramana Reddy, Rashmi Patnayak
No abstract text is available yet for this article.
January 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28528604/a-multicenter-clinical-study-of-expected-and-unexpected-side-reactions-during-and-after-skin-cancer-treatment-by-photodynamic-therapy
#16
Kate C Blanco, Natalia M Inada, Ana P Silva, Mirian D Stringasci, Hilde H Buzzá, Dora P Ramirez, Ana G Sálvio, Lilian T Moriyama, Cristina Kurachi, Vanderlei S Bagnato
Photodynamic therapy (PDT) has been widely used for oncologic indications, especially nonmelanoma skin cancer such as superficial and nodular basal cell carcinoma (BCC). We present a multicenter clinical study conducted between 2012 and 2014 analyzing the adverse reactions during and after PDT with a standardized protocol in 866 lesions. A total of 728 patients with positive clinical and histopathological diagnosis for BCC with up to 2 cm diameter were treated. The procedure consisted of curettage and topical application of cream containing 20% methyl 5-aminolevulinate...
2017: Skinmed
https://www.readbyqxmd.com/read/28526992/epithelial-mesenchymal-transition-emt-in-metastatic-breast-cancer-in-omani-women
#17
Ritu Lakhtakia, Adil Aljarrah, Muhammad Furrukh, Shyam S Ganguly
Breast cancer (BC) in Oman affects younger women and has a more aggressive course. Clinical and biological variables like age, pregnancy, tumor size, type, grade, receptor expression and proliferation predict disease aggression but there is no direct predictor of metastasis except lymphovascular invasion. Epithelial-mesenchymal transition (EMT) is characterized by epithelial cells losing epithelial and acquiring mesenchymal morpho-immunophenotypic characteristics. In tumors, EMT-like transitions may signify a metastatic phenotype and have features in common with cancer stem cells (CSC) which show resistance to chemotherapy...
May 19, 2017: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#18
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
May 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28525403/genetic-diseases-associated-with-an-increased-risk-of-skin-cancer-development-in-childhood
#19
Alexander L Fogel, Kavita Y Sarin, Joyce M C Teng
PURPOSE OF REVIEW: Childhood skin cancers are relatively rare and may indicate an underlying genetic disorder. The increasing elucidation of genetic pathways is changing the diagnosis and management of genetic skin cancer susceptibility syndromes. In this review, we provide an overview of genetic conditions that predispose to skin cancer development in childhood and signs that providers should assess when evaluating affected individuals. RECENT FINDINGS: In basal cell nevus syndrome (BCNS), the patched2 (PTCH2) and suppressor of fused (SUFU) genes have been implicated in disease pathogenesis...
May 18, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28525331/an-immunohistochemical-analysis-of-lymphocytic-infiltrations-in-canine-skin-cancers
#20
J A Madej, J P Madej, S Dzimira, M Nowak
Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Twenty basal cell carcinoma, 20 non-keratinizing squamous cell carcinoma, 20 keratinizing squamous cell carcinoma and 8 sebaceous gland carcinoma samples which were accompanied by a lymphocytic infiltration and/or secondary lymphatic follicles were verified histopathologically...
March 28, 2017: Polish Journal of Veterinary Sciences
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