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https://www.readbyqxmd.com/read/29741259/primary-red-cell-hydration-disorders-pathogenesis-and-diagnosis
#1
A Caulier, R Rapetti-Mauss, H Guizouarn, V Picard, L Garçon, C Badens
Hydration status is critical for erythrocyte survival and is mainly determined by intracellular cation content. Active pumps, passive transporters, and ion channels are the key components of volume homeostasis, whereas water passively fits ionic movements. Whenever cation content increases, erythrocyte swells, whereas it shrinks when cation content decreases. Thus, inappropriate cation leak causes erythrocyte hydration disorders, hemolytic anemia, and characteristic red cell shape abnormalities named stomatocytosis...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29733422/soluble-cd146-and-b-type-natriuretic-peptide-dissect-overhydration-into-functional-components-of-prognostic-relevance-in-haemodialysis-patients
#2
Mattia Arrigo, Seraina Von Moos, Kerem Gerritsen, Malha Sadoune, Kamonwan Tangvoraphonkchai, Andrew Davenport, Alexandre Mebazaa, Stephan Segerer, Pietro E Cippà
Background: Accurate volume status evaluation and differentiation of cardiac and non-cardiac components of overhydration (OH) are fundaments of optimal haemodialysis (HD) management. Methods: This study, by combining bioimpedance measurements, cardiovascular biomarkers and echocardiography, aimed at dissecting OH into its major functional components, and prospectively tested the association between cardiac and non-cardiac components of OH with mortality. In the first part, we validated soluble CD146 (sCD146) as a non-cardiac biomarker of systemic congestion in a cohort of 30 HD patients...
May 4, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29717908/comparison-of-greenlight-laser-photoselective-vaporization-and-thulium-laser-enucleation-for-nonmuscle-invasive-bladder-cancer
#3
Meihua Lu, Xiaolong Liu
OBJECTIVE: To evaluate the safety and efficacy of GreenLight laser vaporization and thulium laser enucleation for nonmuscle invasive bladder cancer (NMIBC). PATIENTS AND METHODS: A total of 150 patients of NMIBC who underwent either GreenLight laser vaporization (Group A, n = 78) or thulium laser enucleation (Group B, n = 72) were analyzed, respectively. The preoperative, intraoperative, and postoperative clinical data were recorded and compared in the two groups...
May 2, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29664189/hydration-and-nutritional-status-in-patients-on-home-dialysis-a-single-centre-study
#4
Janet S C Li, John Y H Chan, Mandy M Y Tai, So M Wong, S M Pang, Fanny Y F Lam, Carmen H M Chu, Chris S Y Ching, Joseph H S Wong, W L Chak
BACKGROUND: Over-hydration (OH) and malnutrition are prevalent among patients on dialysis therapy. The prevalence of OH and malnutrition as well as the risk factors associated with OH and malnutrition in our patients on home peritoneal dialysis (PD) and home haemodialysis (HD) are examined. DESIGN AND METHODS: This was a cross-sectional study. The hydration and nutritional status of the study groups were assessed by a Body Composition Monitor. Patients who were stable on home dialysis therapy for over one year were invited to participate...
April 17, 2018: Journal of Renal Care
https://www.readbyqxmd.com/read/29596717/influence-of-body-composition-and-nutrition-parameters-in-handgrip-strength-are-there-differences-by-sex-in-hemodialysis-patients
#5
Cristina Garagarza, Ana Laura Flores, Ana Valente
BACKGROUND: Hemodialysis (HD) patients are vulnerable to multiple metabolic and nutrition derangements, leading to changes in body composition. Handgrip strength (HGS) has been used as a nutrition marker. We aimed to evaluate the relationship between HGS and lean tissue mass (LTM) with several parameters in HD patients and develop HGS predictive equations. METHODS: Cross-sectional study with 155 patients in HD treatment for ≥3 months. Body composition was assessed through bioimpedance spectroscopy...
December 18, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29590459/systemic-haemodynamics-in-haemodialysis-intradialytic-changes-and-prognostic-significance
#6
Stefanie Haag, Björn Friedrich, Andreas Peter, Hans-Ulrich Häring, Nils Heyne, Ferruh Artunc
Background: Although haemodialysis (HD) leads to alterations of systemic haemodynamics that can be monitored using dilution methods, there is a lack of data on the diagnostic and prognostic significance of haemodynamic monitoring during routine HD. Methods: In this multicentre study, we measured cardiac index (CI), access flow (AF) and central blood volume index (CBVI) during a single HD session in stable HD patients (n = 215) using the Transonic HD03 monitor (Transonic, Ithaca, NY, USA)...
March 26, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29576357/longitudinal-changes-in-phase-angle-by-bioimpedance-in-intensive-care-patients-differ-between-survivors-and-non-survivors
#7
L H Ellegård, P Petersen, L Öhrn, I Bosaeus
BACKGROUND & AIMS: Intensive care (ICU) patients suffer from metabolic stress, creating a catabolic state which might disturb nutritional status and body composition. Alterations in body fluid compartments by disease or massive volume resuscitation could invalidate bioimpedance hydrometry. Still bioimpedance might give other information. METHODS: 52 ICU patients (35 male, 17 female, mean age 66 years), BMI 29,2 were assessed by bioimpedance spectroscopy. Phase angle (PhA) at 50 kHz was assessed...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29559788/the-relationship-between-hydration-status-male-sexual-dysfunction-and-depression-in-hemodialysis-patients
#8
Kamal Hassan, Yotam Elimeleh, Mona Shehadeh, Hassan Fadi, Irina Rubinchik
Background: Disturbances in sexual function are common among dialysis patients. Normal erections require a complex balance of physiological, psychological, emotional, hormonal, neurological and vascular factors. This study examined a possible association of overhydration (OH) with male sexual dysfunction and depression in hemodialysis (HD) patients. Patients and methods: This cross-sectional study assessed hydration status by whole-body bioimpedance spectroscopy in patients on maintenance HD for more than 12 months...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29559519/overhydrated-stomatocytosis-associated-with-a-complex-rhag-genotype-including-a-novel-de-novo-mutation
#9
Manu Jamwal, Anu Aggarwal, Man Updesh Singh Sachdeva, Prashant Sharma, Pankaj Malhotra, Arindam Maitra, Reena Das
Overhydrated stomatocytosis is a rare autosomal dominant disorder known to cause variably severe haemolytic anaemia due to heterozygous mutations in the RHAG gene. We report a 26-year-old man with recurring jaundice, splenohepatomegaly and mild chronic haemolytic anaemia with significant stomatocytosis. Extensive haemolytic work-up including flow cytometry for eosin-5'-maleimide and CD47 expression levels was carried out. Targeted resequencing revealed two probably causative heterozygous mutations in RHAG (Leu336Ser and Ile149Met) and one heterozygous mutation in ANK1 (Glu1046Lys) ...
March 20, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29535377/bioimpedance-defined-overhydration-predicts-survival-in-end-stage-kidney-failure-eskf-systematic-review-and-subgroup-meta-analysis
#10
Matthew Tabinor, Emma Elphick, Michael Dudson, Chun Shing Kwok, Mark Lambie, Simon J Davies
Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in which comorbidity and overhydration, quantified by whole body bioimpedance (BI), were reported. PubMed, EMBASE, PsychInfo and the Cochrane trial database were searched (1990-2017). Independent reviewers appraised studies including methodological quality (assessed using QUIPS)...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523608/considering-exercise-associated-hyponatraemia-as-a-continuum
#11
Douglas Lewis, Andrew Blow, Jonathan Tye, Tamara Hew-Butler
Exercise-associated hyponatraemia (EAH) always involves a component of overhydration relative to available exchangeable sodium stores. In the majority of cases, this is purely due to excessive consumption of fluids during exercise. In a lesser number of cases, it is apparent that excessive sodium loss through sweat may play a role by decreasing the amount of acutely available exchangeable sodium. Two cases demonstrating the latter, one in an individual with cystic fibrosis (CF) and another in an endurance athlete without CF, demonstrate how elevated dermal sweat losses may contribute to a relative dilutional EAH along a pathophysiological continuum...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29489063/plasma-kallikrein-activates-the-epithelial-sodium-channel-in-vitro-but-is-not-essential-for-volume-retention-in-nephrotic-mice
#12
S Haerteis, A Schork, T Dörffel, B N Bohnert, R Nacken, M Wörn, M Xiao, D Essigke, A Janessa, A H Schmaier, E P Feener, H-U Häring, M Bertog, C Korbmacher, F Artunc
AIM: Recent work has demonstrated that activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases causes sodium retention in nephrotic syndrome. The aim of this study was to elucidate a potential role of plasma kallikrein (PKLK) as a candidate serine protease in this context. METHODS: We analysed PKLK in the urine of patients with chronic kidney disease (CKD, n = 171) and investigated its ability to activate human ENaC expressed in Xenopus laevis oocytes...
February 28, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29446172/measuring-the-prevalence-of-intradialytic-hypotension-in-a-satellite-dialysis-clinic-are-we-too-complacent
#13
Ulrich Steinwandel, Nick Gibson, Mandy Towell-Barnard, Richard Parsons, James Jr Rippey, Johan Rosman
AIMS AND OBJECTIVES: To measure the prevalence of symptomatic (S-IDH) and asymptomatic intradialytic hypotension (A-IDH) or postdialysis overhydration in a satellite haemodialysis clinic in Western Australia. BACKGROUND: Intradialytic hypotension is one of the most common side effects of haemodialysis caused by ultrafiltration provoking a temporary volume depletion. The prevalence of asymptomatic hypotension during dialysis has been rarely reported, but is considered to have the same negative consequences as symptomatic hypotension on various end organs like the brain and the gastrointestinal tract...
April 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29386302/does-routine-bioimpedance-guided-fluid-management-provide-additional-benefit-to-non-anuric-peritoneal-dialysis-patients-results-from-compass-clinical-trial
#14
Kook-Hwan Oh, Seon Ha Baek, Kwon-Wook Joo, Dong Ki Kim, Yon Su Kim, Sejoong Kim, Yun Kyu Oh, Byoung Geun Han, Jae Hyun Chang, Wookyung Chung, Ki Young Na
INTRODUCTION: In peritoneal dialysis (PD) patients, volume overload is related to cardiac dysfunction and mortality, while intravascular volume depletion is associated with a rapid decline in the residual renal function (RRF). This study sought to determine the clinical usefulness of bioimpedance spectroscopy (BIS)-guided fluid management for preserving RRF and cardiac function in PD patients. SUBJECTS AND METHODS: This is a multicenter, prospective, open-label study that was conducted over a 1-year period (NCT01887262)...
March 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29365179/collapse-in-the-heat-from-overhydration-to-the-emergency-room-three-cases-of-exercise-associated-hyponatremia-associated-with-exertional-heat-illness
#15
Robert C Oh, Bryan Malave, Justin D Chaltry
Exertional heat illness and exercise-associated hyponatremia continue to be a problem in military and recreational events. Symptoms of hyponatremia can be mistaken for heat exhaustion or heat stroke. We describe three cases of symptomatic hyponatremia initially contributed to heat illnesses. The first soldier was a 31-yr-old female who "took a knee" at mile 6 of a 12-mile foot march. She had a core temperature of 100.9°F, a serum sodium level of 129 mmol/L, and drank approximately 4.5 quarts of water in 2 h...
March 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29347876/risk-of-overhydration-and-low-lean-tissue-index-as-measured-using-a-body-composition-monitor-in-patients-on-hemodialysis-a-systemic-review-and-meta-analysis
#16
Seun Deuk Hwang, Jin Ho Lee, Seoung Woo Lee, Joong Kyung Kim, Moon-Jae Kim, Joon Ho Song
Overhydration and sarcopenia, related to an individual's nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29298736/multiple-frequency-bioimpedance-devices-for-fluid-management-in-people-with-chronic-kidney-disease-receiving-dialysis-a-systematic-review-and-economic-evaluation
#17
Graham Scotland, Moira Cruickshank, Elisabet Jacobsen, David Cooper, Cynthia Fraser, Michal Shimonovich, Angharad Marks, Miriam Brazzelli
BACKGROUND: Chronic kidney disease (CKD) is a long-term condition requiring treatment such as conservative management, kidney transplantation or dialysis. To optimise the volume of fluid removed during dialysis (to avoid underhydration or overhydration), people are assigned a 'target weight', which is commonly assessed using clinical methods, such as weight gain between dialysis sessions, pre- and post-dialysis blood pressure and patient-reported symptoms. However, these methods are not precise, and measurement devices based on bioimpedance technology are increasingly used in dialysis centres...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29282003/fluid-status-evaluation-by-inferior-vena-cava-diameter-and-bioimpedance-spectroscopy-in-pediatric-chronic-hemodialysis
#18
Xavier Torterüe, Laurène Dehoux, Marie-Alice Macher, Olivier Niel, Thérésa Kwon, Georges Deschênes, Julien Hogan
BACKGROUND: Evaluation of patient's dry weight remains challenging in chronic hemodialysis (HD) especially in children. Inferior Vena Cava (IVC) measurement was reported useful to assess fluid overload both in adults and children. METHODS: We performed a monocentric prospective study to evaluate the relation between predialytic IVC diameter measurements and hydration status evaluated by physicians and bioimpedance spectroscopy (BIS) and between IVC measurements and persistent hypertension...
December 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29248911/irisin-and-volume-overload-are-associated-with-protein-energy-wasting-in-peritoneal-dialysis-patients
#19
Si-Jia Zhou, Qing-Feng Han, Ai-Hua Zhang, Wen Tang, Ling-Hua Sun
BACKGROUND/AIMS: Protein energy wasting (PEW) is a common medical phenomenon that is observed in maintenance dialysis patients. PEW also increases morbidity and mortality of these patients. Its pathogenesis is unclear. We hypothesize that serum irisin levels and volume overload may induce PEW in peritoneal dialysis (PD) patients. The aim of this study is to measure serum irisin levels, evaluate volume status of PD patients, and study their correlations with PEW in PD patients. METHODS: This study is a cross-sectional study with 160 PD patients from the PD center of Peking University Third Hospital and 35 healthy control subjects...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29136192/assessing-the-hydration-status-of-children-with-chronic-kidney-disease-and-on-dialysis-a-comparison-of-techniques
#20
Caroline S Y Eng, Devina Bhowruth, Mark Mayes, Lynsey Stronach, Michelle Blaauw, Amy Barber, Lesley Rees, Rukshana C Shroff
Background: Fluid balance is pivotal in the management of children with chronic kidney disease (CKD) and on dialysis. Although many techniques are available to assess fluid status, there are only a few studies for children, of which none have been comparable against cardiovascular outcome measures. Methods: We performed a longitudinal study in 30 children with CKD5-5D and 13 age-matched healthy controls (71 measurements) to determine a correlation between optimal weight by bioimpedance spectroscopy (Wt-BIS) and clinical assessment (Wt-CA)...
May 1, 2018: Nephrology, Dialysis, Transplantation
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