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Wilfried Dimpfel, Leonie Schombert, Nigel Gericke
ETHNOPHARMACOLOGICAL RELEVANCE: The endemic succulent South African plant, Sceletium tortuosum (L.) N.E. Br. (synonym Mesembryanthemum tortuosum L.), of the family Mesembryathemaceae, has an ancient oral tradition history of use by San and Khoikhoi people as an integral part of the indigenous culture and materia medica. A special standardized extract of Sceletium tortuosum (Zembrin®) has been developed and tested pre-clinically in rats, and clinically in healthy subjects. AIM OF THE STUDY: The present investigation aimed at the construction of electropharmacograms of Zembrin® in the presence of three dosages (2...
January 11, 2016: Journal of Ethnopharmacology
Simon Chiu, Nigel Gericke, Michel Farina-Woodbury, Vladimir Badmaev, Hana Raheb, Kristen Terpstra, Joalex Antongiorgi, Yves Bureau, Zack Cernovsky, Jirui Hou, Veronica Sanchez, Marissa Williams, John Copen, Mariwan Husni, Liz Goble
Introduction. Converging evidence suggests that PDE-4 (phosphodiesterase subtype 4) plays a crucial role in regulating cognition via the PDE-4-cAMP cascade signaling involving phosphorylated cAMP response element binding protein (CREB). Objective. The primary endpoint was to examine the neurocognitive effects of extract Sceletium tortuosum (Zembrin) and to assess the safety and tolerability of Zembrin in cognitively healthy control subjects. Method. We chose the randomized double-blind placebo-controlled cross-over design in our study...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
Timothy S Murbach, Gábor Hirka, Ilona Pasics Szakonyiné, Nigel Gericke, John R Endres
A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety of Sceletium tortuosum, a South African plant with a long history of traditional ingestion, is marketed under the trade name Zembrin(®) as an ingredient for use in functional foods and dietary supplements. It is standardized to contain 0.35-0.45% total alkaloids (mesembrenone and mesembrenol ≥60%, and mesembrine <20%). A 14-day repeated oral toxicity study was conducted at 0, 250, 750, 2500, and 5000 mg/kg bw/day...
December 2014: Food and Chemical Toxicology
David Terburg, Supriya Syal, Lisa A Rosenberger, Sarah Heany, Nicole Phillips, Nigel Gericke, Dan J Stein, Jack van Honk
The South African endemic plant Sceletium tortuosum has a long history of traditional use as a masticatory and medicine by San and Khoikhoi people and subsequently by European colonial farmers as a psychotropic in tincture form. Over the past decade, the plant has attracted increasing attention for its possible applications in promoting a sense of wellbeing and relieving stress in healthy individuals and for treating clinical anxiety and depression. The pharmacological actions of a standardized extract of the plant (Zembrin) have been reported to be dual PDE4 inhibition and 5-HT reuptake inhibition, a combination that has been argued to offer potential therapeutic advantages...
December 2013: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Haylene Nell, Mirna Siebert, Pashini Chellan, Nigel Gericke
OBJECTIVES: The objective of the study was to evaluate the safety and tolerability of two doses (8 mg and 25 mg once daily) of a 2:1 standardized extract of the South African medicinal plant Sceletium tortuosum (L.) N.E. Br., trademarked Zembrin,(®) in healthy adult volunteers over a three-month period. DESIGN: This was a randomized, double-blind, parallel-group, placebo-controlled single center study. SETTING: Tiervlei Trial Centre, Karl Bremer Hospital, Bellville, Cape Town, South Africa...
November 2013: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Alan L Harvey, Louise C Young, Alvaro M Viljoen, Nigel P Gericke
ETHNOPHARMACOLOGICAL RELEVANCE: The South African plant Sceletium tortuosum has been known for centuries for a variety of traditional uses, and, more recently, as a possible source of anti-anxiety or anti-depressant effects. A standardised extract Zembrin(®) was used to test for pharmacological activities that might be relevant to the ethnopharmacological uses, and three of the main alkaloids were also tested. MATERIALS AND METHODS: A standardised ethanolic extract was prepared from dried plant material, along with the purified alkaloids mesembrine, mesembrenone and mesembrenol...
October 11, 2011: Journal of Ethnopharmacology
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