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Postherpetic neuralgia

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https://www.readbyqxmd.com/read/29781961/-from-ear-to-trunk-mri-reveals-referral-of-pain
#1
Julia Forstenpointner, Stephan Wolff, Patrick W Stroman, Olav Jansen, Stefanie Rehm, Ralf Baron, Janne Gierthmühlen
Referred and projecting pain can be observed in acute and chronic pain states. We present the case of a 69-year-old female patient with postherpetic neuralgia (PHN) in dermatome Th2/3 who reported that touching the ipsilateral earlap (dermatome C2) would enhance pain and dynamic mechanical allodynia (DMA) in the affected Th2/3-dermatome. The aim was to investigate possible underlying mechanisms of this phenomenon using the capsaicin experimental pain sensitization model, quantitative sensory testing (QST) and functional spinal and supraspinal MRI (fMRI)...
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29771216/mindfulness-based-cognitive-hypnotherapy-and-skin-disorders
#2
Philip D Shenefelt
Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo...
July 2018: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/29766448/cross-sectional-study-on-hospitalizations-related-to-herpes-zoster-in-an-italian-region-2008-2016
#3
Silvia Cocchio, Tatjana Baldovin, Patrizia Furlan, Chiara Bertoncello, Alessandra Buja, Mario Saia, Marco Fonzo, Vincenzo Baldo
INTRODUCTION: To assess the burden of herpes zoster (HZ) by analyzing HZ-related hospital admissions. METHODS: We conducted a population-based descriptive cross-sectional study on all hospitalizations for HZ among the resident population admitted to all public and accredited private hospitals in the Veneto Region (north-east Italy) during the years 2008-2016. HZ hospitalizations were identified from the International Classification of Diseases codes in the hospital discharge records...
May 15, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29742472/impact-of-postherpetic-neuralgia-a-six-year-population-based-analysis-on-people-aged-50-years-or-older-%C3%A2-%C3%A2-%C3%A2
#4
Cintia Muñoz-Quiles, Mónica López-Lacort, Alejandro Orrico-Sánchez, Javier Díez-Domingo
OBJECTIVES: To estimate the incidence and burden of postherpetic neuralgia (PHN) and to investigate risk factors for PHN in the Valencia Region of Spain. METHODS: Data were extracted from population and healthcare databases from the Valencia Region (2009-2014). Herpes zoster (HZ) and PHN were defined using ICD-9 codes and drug prescriptions in people aged ≥ 50 years. The risk of HZ patients for developing PHN and potential risk factors (diabetes mellitus, COPD and heart failure) were investigated...
May 6, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29740216/altered-functional-connectivity-density-in-patients-with-herpes-zoster-and-postherpetic-neuralgia
#5
Shunda Hong, Lili Gu, Fuqing Zhou, Jiaqi Liu, Muhua Huang, Jian Jiang, Laichang He, Honghan Gong, Xianjun Zeng
Purpose: The aim of this study was to explore intrinsic functional connectivity patterns in patients with herpes zoster (HZ) and postherpetic neuralgia (PHN). Patients and methods: Thirty-three right-handed HZ patients (13 males; mean age 57.15±9.30 years), 22 right-handed PHN patients (9 males; mean age 66.13±6.77 years), and 28 well-matched healthy controls (HC) (9 males; mean age 54.21±7.72 years) underwent resting-state functional magnetic resonance imaging for intrinsic functional connectivity analyses...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29721782/herpes-zoster-in-frail-elderly-patients-prevalence-impact-management-and-preventive-strategies
#6
REVIEW
Ermanno Zorzoli, Francesca Pica, Giulia Masetti, Elisabetta Franco, Antonio Volpi, Giovanni Gabutti
Population aging is a worldwide phenomenon with significant and manifold impacts on society. Advanced age correlates with the onset of frailty. In this vulnerable state, the immune response is weakened and a higher susceptibility to infectious diseases is observed. The present narrative review aims to cover the topic of herpes zoster (HZ) and its complications in frail populations. The lifetime risk of developing HZ is estimated at about 20-30%, and the risk increases with age. In older people, HZ can lead to the inability to recover the lifestyle, the interests, and the level of activity that existed before its development...
May 2, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29708930/management-of-chronic-complications-associated-with-herpes-zoster-ophthalmicus
#7
Saujanya Vadoothker, Bennie H Jeng
PURPOSE OF REVIEW: Herpes zoster ophthalmicus (HZO) has the potential to cause significant visual morbidity and functional disability in patients with recalcitrant disease, keratitis, and postherpetic neuralgia. This article will review the current methods of prevention and treatment of anterior segment-related chronic complications of HZO. RECENT FINDINGS: HZO-related anterior segment ocular complications can range to include conjunctivitis, keratitis, and uveitis that can all be difficult to manage...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29698250/the-analgesic-and-emotional-response-to-intravenous-lidocaine-infusion-in-the-treatment-of-postherpetic-neuralgia-a-randomized-double-blinded-placebo-controlled-study
#8
Hui Liu, Fan Lu, Dan Zhou, Yan Yin, Jun Li, BangXiang Yang, Li Song, Ling Ye, Hong Xiao
OBJECTIVES: This study evaluates the analgesic efficacy and emotional response of intravenous lidocaine infusion compared with placebo in patients with postherpetic neuralgia(PHN). METHODS: In this randomized, double-blinded study, patients with PHN received 5▒mg/kg intravenous lidocaine infusion or placebo. The primary outcome was pain relief measured by Visual Analogue Scale (VAS), Von Frey and area of allodynia. Moreover, emotional status of anxiety and depression were evaluated by Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS)...
April 25, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29686811/preliminary-study-on-contrast-flow-analysis-of-thoracic-transforaminal-epidural-block
#9
Ji Hee Hong, Kyoung Min Noh, Ki Bum Park
Background: The thoracic transforaminal epidural block (TTFEB) is usually performed to treat herpes zoster or postherpetic neuralgia (PHN). Especially, multiple segmental involvements and approximate contrast medium spread range, according to volume, help to choose the proper drug volume in the transforaminal epidural block. This study investigated the contrast medium spread patterns of 1-ml to 3-ml TTFEBs. Methods: A total of 26 patients with herpes zoster or PHN were enrolled in this study...
April 2018: Korean Journal of Pain
https://www.readbyqxmd.com/read/29680914/the-potential-public-health-impact-of-herpes-zoster-vaccination-of-people-aged-%C3%A2-50-years-in-japan-results-of-a-markov-model-analysis
#10
Daisuke Watanabe, Akiko Mizukami, Katsiaryna Holl, Desmond Curran, Desirée Van Oorschot, Lijoy Varghese, Makoto Shiragami
INTRODUCTION: The aim of this study was to compare the public health impact of introducing two herpes zoster (HZ) vaccines into the vaccination programs for the Japanese population aged ≥ 50 years: a single-dose Varicella Vaccine Live (VVL) or a two-dose adjuvanted Recombinant Zoster Vaccine (RZV). METHODS: A multi-cohort static Markov model was developed to follow age cohorts (50-59, 60-69, 70-79 and ≥ 80 years) over their remaining lifetime. Japan-specific data inputs for the model were obtained from Japanese data sources...
April 21, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29671676/effects-of-gabapentin-pregabalin-and-gastroretentive-gabapentin-on-simulated-driving-daytime-sedation-and-cognition
#11
Peter Schmidt, Srinivas Rao
AIM: Randomized Phase I study examining the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on simulated driving performance, sedation and cognitive function in healthy volunteers (n = 32). METHODS: Driving attentiveness, sleepiness and cognition were evaluated prior to subjects receiving study doses. Blood samples were collected during each treatment. RESULTS: Subjects receiving gastroretentive gabapentin showed less change in variation in lateral lane position (p = 0...
April 19, 2018: Pain Management
https://www.readbyqxmd.com/read/29644194/safety-and-efficacy-of-different-systemic-treatment-modalities-for-acute-pain-of-herpes-zoster-a-pilot-study
#12
Sanjiv Choudhary, Shivani Dhande, Sachin Kharat, A L Singh
Background: Herpes zoster is a viral infection of skin caused by Varicella Zoster virus. The most important symptom for which the patient seeks medical advice is pain, which is perceived before the development of rash and lasts even after its resolution. The pain during the first 30 days after onset of herpes zoster is known as acute herpetic neuralgia. The aim of this study was to compare the efficacy and side-effects of different systemic treatment modalities for acute herpes zoster neuralgia...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29606812/usefulness-of-inflammatory-markers-for-the-prediction-of-postherpetic-neuralgia-in-patients-with-acute-herpes-zoster
#13
Jun Young Kim, Gyeong-Hun Park, Min Ji Kim, Hyun Bo Sim, Weon Ju Lee, Seok-Jong Lee, Shin-Woo Kim, Young Hoon Jeon, Yong Hyun Jang, Do Won Kim
Background: Increasing evidence suggests a pivotal role for neuronal inflammation in response to replicating varicella zoster virus in the development of postherpetic neuralgia (PHN). Objective: In this study, we investigated the value of serum levels of various inflammatory markers in acute herpes zoster (HZ) as predictors for the development of PHN. Methods: A total of 116 patients with acute HZ were enrolled in this study. We measured scores on the pain visual analogue scale (VAS) at baseline and at 1, 3, and 6 months after diagnosis of HZ...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29597081/a-comparison-of-the-assay-sensitivity-of-average-and-worst-pain-intensity-in-pharmacologic-trials-an-acttion-systematic-review-and-meta-analysis
#14
REVIEW
Shannon M Smith, Mark P Jensen, Hua He, Rachel Kitt, James Koch, Andrew Pan, Laurie B Burke, John T Farrar, Michael P McDermott, Dennis C Turk, Robert H Dworkin
Identifying methods to improve assay sensitivity in randomized clinical trials (RCTs) may facilitate the discovery of efficacious pain treatments. RCTs evaluating pain treatments typically use average pain intensity (API) or worst pain intensity (WPI) as the primary efficacy outcome. However, little evidence is available comparing the assay sensitivity of these 2 measures. In this systematic review and meta-analysis, we comprehensively reviewed all low back pain, osteoarthritis pain, fibromyalgia, diabetic peripheral neuropathy pain, and postherpetic neuralgia RCTs that used a parallel group design...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29574434/herpes-zoster-ophthalmicus-evolving-into-headache-characterised-as-hemicrania-continua
#15
Sanjay Prakash, Ankit Dave, Hemant Joshi
Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster infection. However, a few patients may develop different types of pain after herpetic lesions. We are reporting two patients who developed postherpetic hemicrania continua (HC). Case 1: a 54-year-old woman had a 10-month history of continuous left-sided pain with superimposed exacerbations. The pain started with the onset of herpetic lesions in the ophthalmic division. The lesions subsided in a few weeks. However, the pain persisted and it responded exclusively to indomethacin...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29563324/binding-characteristics-and-analgesic-effects-of-mirogabalin-a-novel-ligand-for-the-%C3%AE-2-%C3%AE-subunit-of-voltage-gated-calcium-channels
#16
Yuki Domon, Naohisa Arakawa, Tatsuya Inoue, Fumihiko Matsuda, Makoto Takahashi, Naotoshi Yamamura, Kiyonori Kai, Yutaka Kitano
Mirogabalin ([(1 R ,5 S ,6 S )-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the α2 δ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. In the present study, we investigated the in vitro binding characteristics and in vivo analgesic effects of mirogabalin, compared to those of pregabalin, a standard α2 δ ligand. Mirogabalin showed potent and selective binding affinities for the α2 δ subunits, while having no effects on 186 off-target proteins...
March 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29554872/epidemiology-and-long-term-disease-burden-of-herpes-zoster-and-postherpetic-neuralgia-in-taiwan-a-population-based-propensity-score-matched-cohort-study
#17
Wan-Hsuan Lu, Chih-Wan Lin, Chen-Yu Wang, Liang-Kung Chen, Fei-Yuan Hsiao
BACKGROUND: The objectives of this study were to characterize the burden of herpes zoster, as well as the longitudinal and incremental changes of healthcare service utilization among individuals with herpes zoster and postherpetic neuralgia (PHN) compared to those without. METHODS: Using the National Health Insurance Research Database (NHIRD), we established a herpes zoster cohort of people diagnosed with herpes zoster between 2004 and 2008 as study cases. Another subset of the NHIRD, which was randomly selected from all elderly beneficiaries between 2004 and 2008 served as a non-herpes-zoster elderly control pool...
March 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29533387/dilute-lidocaine-suppresses-ectopic-neuropathic-discharge-in-drgs-without-blocking-axonal-propagation-a-new-approach-to-selective-pain-control
#18
Pini Koplovitch, Marshall Devor
Ectopic impulse discharge (ectopia) generated in the soma of afferent neurons in dorsal root ganglia (DRGs) following nerve injury is thought to be a major contributor to neuropathic pain. The DRG is thus a prime interventional target. The process of electrogenesis (impulse generation) in the DRG is far more sensitive to systemically administered Na channel blockers than the process of impulse propagation along sensory axons. It should therefore be possible to selectively suppress DRG ectopia with local application of membrane stabilizing agents without blocking normal impulse traffic...
March 12, 2018: Pain
https://www.readbyqxmd.com/read/29486015/gabapentin-for-chronic-neuropathic-pain
#19
Andrew Moore, Sheena Derry, Philip Wiffen
Clinical Question: Is gabapentin associated with pain relief in people with chronic neuropathic pain? Bottom Line: Oral gabapentin (1200-3600 mg/d for 4-12 weeks) for patients with moderate or severe neuropathic pain from postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN) is associated with pain reduction of at least 50% in 14% to 17% more patients than placebo.
February 27, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29463421/complications-of-herpes-zoster-in-immunocompetent-older-adults-incidence-in-vaccine-and-placebo-groups-in-two-large-phase-3-trials
#20
Martina Kovac, Himal Lal, Anthony L Cunningham, Myron J Levin, Robert W Johnson, Laura Campora, Antonio Volpi, Thomas C Heineman
BACKGROUND: An adjuvanted herpes zoster (HZ) subunit vaccine, HZ/su, demonstrated high efficacy against HZ and postherpetic neuralgia (PHN) in two randomized, observer-blind, placebo-controlled trials in adults aged ≥50 and ≥70 years (ZOE-50 and ZOE-70, respectively). METHODS: Data from ZOE-50 and ZOE-70 trials were analyzed to evaluate the efficacy of HZ/su against mortality, hospitalizations, and non-PHN complications of HZ including HZ-associated vasculitis, stroke, and disseminated, ophthalmic, neurologic, and visceral diseases...
March 14, 2018: Vaccine
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