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Postherpetic neuralgia

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https://www.readbyqxmd.com/read/29125423/management-of-chronic-neuropathic-pain-with-single-and-compounded-topical-analgesics
#1
Nebojsa Nick Knezevic, Tatiana Tverdohleb, Farid Nikibin, Ivana Knezevic, Kenneth D Candido
The goal of our review was to emphasize important aspects that physicians should take into consideration when prescribing topical analgesics as part of chronic neuropathic pain treatment. We discuss the dermatopharmacokinetics and microstructural components of the skin, differences between topical and transdermal drug delivery, and topical medication effects on peripheral neuropathy and central sensitization. Even though the US FDA approved topical analgesics are 8%-capsaicin and 5%-lidocaine patches for treating postherpetic neuralgia, there are many other studies conducted on the efficacy of topical ketamine cream, clonidine gel, topical gabapentin, topical baclofen and topical phenytoin for peripheral neuropathic pain, either alone or in combination with other formulations...
November 10, 2017: Pain Management
https://www.readbyqxmd.com/read/29118328/decreased-absolute-numbers-of-cd3-t-cells-and-cd8-t-cells-during-aging-in-herpes-zoster-patients
#2
Li Wei, Jianguang Zhao, Wei Wu, Yu Zhang, Xuyan Fu, Lifeng Chen, Xiaoting Wang
Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age is a key risk factor for HZ, and postherpetic neuralgia (PHN) is the main sequelae. Until now, no index has been available to predict the pathogenesis of PHN, and rare reports have focused on the immune response during aging and PHN. In this study, we selected immunoglobulin and complement proteins as markers for humoral immunity, while T lymphocyte subsets and natural killer (NK) cells were selected as markers for cell immunity, to systematically study the characteristics of immune responses in the peripheral blood of HZ patients...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117658/treatment-of-postherpetic-neuralgia-with-5-topical-lidocaine-plaster-%C3%A2-experience-from-a-small-county-hospital-case-report
#3
Maša Kontić, Višnja Vičić-Hudorović, Narcis Hudorović
Postherpetic neuralgia (PHN) characterized by chronic neuropathic pain is a common complication of herpes zoster. We investigated the efficacy, safety and cost of treating refractory chronic neuropathic pain with 5% topical lidocaine plaster (TLP) in a female patient attending pain unit at a small county hospital. An 80-year-old female diagnosed with PHN presented with severe left intercostal allodynia and hyperalgesia up to the root of the fourth to tenth thoracic dermatome. We administered the well established first- and second-line specific medications for PHN, but treatment regimens were not efficient...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29079160/herpes-zoster-in-the-older-adult
#4
REVIEW
Amrita R John, David H Canaday
Herpes zoster (HZ) is the result of reactivation of latent varicella zoster virus (VZV) and occurs most frequently in older adults. Classically, HZ presents as a unilateral, selflimited, dermatomal rash. Postherpetic neuralgia (PHN) is a common sequela, presenting as severe pain that persists after the rash has resolved. In the elderly, PHN can be debilitating and requires a prompt diagnosis, treatment with antivirals, and adequate pain control. A longer-term pain management strategy is required if PHN occurs...
December 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29069724/association-of-serum-ninjurin2-levels-with-neurologic-damage-and-postherpetic-neuralgia-occurrence-an-observational-cohort-study-in-chinese-herpeszoster-patients
#5
Guozhuan Zhang, Yingjiao Sun, Lei Wang, Hui Tian, Lishuang Liang
OBJECTIVES: Postherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic damage related protein, is associated with nerve injury and the occurrence of PHN. RESULTS: Seventy-four of the eighty patients completed the study. On the 7th day of AHN, the patients had significantly higher values of NINJ2, cold-sense dispersion (ΔCS), warm-sense dispersion (ΔWS), cold-pain dispersion (ΔCP), heat-pain dispersion (ΔHP) and NRS score compared to controls...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29036443/the-association-of-perceived-mental-stress-sense-of-purpose-in-life-and-negative-life-events-with-the-risk-of-incident-herpes-zoster-and-postherpetic-neuralgia-the-shez-study
#6
Yukiko Takao, Yoshinobu Okuno, Yasuko Mori, Hideo Asada, Koichi Yamanishi, Hiroyasu Iso
This population-based prospective study examined the relationships of perceived mental stress, sense of purpose in life, and negative life events to the incidence of herpes zoster (HZ) and postherpetic neuralgia (PHN). The data were collected from 12,359 participants (aged ≥50 years old in Shozu County, Kagawa Prefecture, Japan) who answered a self-completed health questionnaire. During a 3-year follow-up between December 2008 and November 2012, HZ and PHN were diagnosed in 400 and 79 subjects, respectively...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29026761/postherpetic-neuralgia-diabetic-neuropathy-and-trigeminal-neuralgia-chronic-peripheral-neuropathic-pain-in-58-480-rural-italian-primary-care-patients
#7
Nicola Buono, Hans Thulesius, Ferdinando Petrazzuoli, Elena Castelli, Marco Cambielli
INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care. AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy. MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29022282/analysis-of-five-cases-of-human-herpesvirus-6-myelitis-among-121-cord-blood-transplantations
#8
Toshimitsu Ueki, Kenichi Hoshi, Yuki Hiroshima, Masahiko Sumi, Naoaki Ichikawa, Masao Ogata, Takako Satou, Takahiro Fukuda, Hikaru Kobayashi
Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. The major symptom identified in all five patients was superficial pain or pruritus linked to segmental levels of the spinal cord. Other identified symptoms were fever or low-grade fever in all five patients, autonomic nerve disorder in four patients, bladder and rectal disturbance in two patients, and extrapyramidal disorder in two patients...
October 11, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29016994/neuromodulation-in-postherpetic-neuralgia-case-reports-and-review-of-the-literature
#9
Svetlana Kurklinsky, Scott C Palmer, Mack J Arroliga, Salim M Ghazi
Objective: Postherpetic neuralgia (PHN) is common in the United States. Current treatment options for PHN are fairly limited. Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are considered mostly experimental and still rarely performed in patients with PHN. Design: Two case reports and a review of the literature. Setting: Tertiary academic medical center. Methods: 1) Pubmed, Ovid, and EBMR databases were searched for all reports that had the following key words: postherpetic neuralgia, spinal cord stimulation, and peripheral nerve stimulation...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28967801/dose-response-of-pregabalin-for-diabetic-peripheral-neuropathy-postherpetic-neuralgia-and-fibromyalgia
#10
Lesley M Arnold, Bill H McCarberg, Andrew G Clair, Ed Whalen, Neal Thomas, Anamaria Jorga, Lynne Pauer, Richard Vissing, Peter W Park
OBJECTIVES: The pregabalin dose-response for pain, Patient Global Impression of Change (PGIC), and sleep quality measures in painful diabetic peripheral neuropathy (pDPN), postherpetic neuralgia (PHN), and fibromyalgia (FM) is relevant for physicians treating these patients. This analysis aimed to demonstrate the dose-response of pregabalin for each indication and describe the onset (incidence), onset/continuation (prevalence), and resolution of adverse events (AEs) occurring during treatment...
October 16, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28966514/a-study-of-the-changes-of-t-helper-17-cells-and-regulatory-t-cells-in-herpes-zoster
#11
Min Sung Kim, Dong Jin Kim, Chan Ho Na, Bong Seok Shin
BACKGROUND: Immunosuppression and age-related deficiencies in cell-mediated immunity are important factors for the reactivation of latent varicella-zoster virus (VZV). CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells and T helper 17 (Th17) cells are closely associated with various viral infections. OBJECTIVE: We analyzed Treg cells and Th17 cells in patients with herpes zoster and investigated their relationship with the reactivation of latent VZV. METHODS: Treg and Th17 cells in peripheral blood and the ratio of Th17 to Treg cells were examined in patients with herpes zoster and healthy controls...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28934778/the-effect-of-early-use-of-supplemental-therapy-on-preventing-postherpetic-neuralgia-a-systematic-review-and-meta-analysis
#12
Xiu-Fang Xing, Zhen-Feng Zhou, Feng-Jiang Zhang, Min Yan
BACKGROUND: Postherpetic neuralgia (PHN) is the most common and refractory complication of herpes zoster (HZ). Aggressive treatment of acute pain in HZ has the potential to prevent the development of PHN, but the preventive efficacy of supplemental therapy commonly used in clinical practice is controversial. OBJECTIVES: Our aim is to examine the efficacy of supplemental therapy in preventing PHN. STUDY DESIGN: A meta-analysis. SETTING: All of the selected studies are randomized controlled trials (RCTs)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28925505/glossopharyngeal-postherpetic-neuralgia-palliated-with-fluoroscopic-guided-nerve-block-a-case-report
#13
Nathaniel M Schuster, Maximilian E Hsia-Kiung
No abstract text is available yet for this article.
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28920039/treatment-option-for-refractory-postherpetic-neuralgia-transversus-abdominis-plane-tap-block-two-case-reports
#14
Sun Kyung Park, Yun Suk Choi
Postherpetic neuralgia (PHN) is a severe neuropathic pain syndrome. The treatment of PHN is complex and refractory in some patients. We present two cases with refractory anterior abdominal wall pain due to PHN that were successfully treated with transversus abdominis plane (TAP) block. The TAP block seems to be an alternative for patients with PHN who suffer from anterior abdominal wall pain accompanied by allodynia and hyperalgesia and do not respond to the existing conservative treatments.
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28879245/effects-of-high-dose-capsaicin-on-tmd-subjects-a-randomized-clinical-study
#15
B K Campbell, R B Fillingim, S Lee, R Brao, D D Price, J K Neubert
Temporomandibular joint disorder (TMD) is a complex musculoskeletal disorder that presents with pain, limited jaw opening, and abnormal noises in the temporomandibular joint. Despite the significant impact that TMD has in terms of suffering and financial burden, relatively few new treatments have emerged; therefore, development of novel treatments to treat TMD pain remains a high priority. The rationale of this study was to use a double-blind, vehicle-controlled clinical trial to evaluate the effects of a high-concentration (8%) capsaicin cream on TMD...
January 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28872473/capsaicin-8-patch-repeat-treatment-in-nondiabetic-peripheral-neuropathic-pain-a-52-week-open-label-single-arm-safety-study
#16
Rafael Gálvez, Marie-Louise Navez, Graeme Moyle, Christian Maihöfner, Malcolm Stoker, Etienne Ernault, Turo J Nurmikko, Nadine Attal
OBJECTIVES: To investigate the long-term safety and tolerability of capsaicin 8% patch repeat treatment in nondiabetic patients with peripheral neuropathic pain. METHODS: A prospective, open-label, observational study in patients with postherpetic neuralgia, posttraumatic or postsurgical nerve injury, HIV-associated distal sensory polyneuropathy, or other peripheral neuropathic pain, and average daily pain score ≥4, who received ≤6 capsaicin 8% patch treatments over 52 weeks according to clinical need (retreatment at 9 to 12 wk intervals)...
October 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28865822/botulinum-toxin-a-might-be-an-alternative-or-adjunct-therapy-for-the-treatment-of-trigeminal-and-postherpetic-neuralgia
#17
Ya-Wei Chen, Sung-Kiang Chuang
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: A systematic review with meta-analyses. Shackleton T, Ram S, Black M, Ryder J, Clark GT, Enciso R. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122(1):61-71. SOURCE OF FUNDING: Information not available TYPE OF STUDY/DESIGN: Systematic review and meta-analysis.
September 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28841868/a-systematic-review-of-the-effectiveness-of-policies-restricting-access-to-pregabalin
#18
Brett R Stacey, Jonathan Liss, Regina Behar, Alesia Sadosky, Bruce Parsons, Elizabeth T Masters, Patrick Hlavacek
BACKGROUND: Formularies often employ restriction policies to reduce pharmacy costs. Pregabalin, an alpha-2-delta ligand, is approved for treatment of fibromyalgia (FM); neuropathic pain (NeP) due to postherpetic neuralgia (PHN), diabetic peripheral neuropathy (pDPN), spinal cord injury; and as adjunct therapy for partial onset seizures. Pregabalin is endorsed as first-line therapy for these indications by several US and EU medical professional societies. However, restriction policies such as prior authorization (PA) and step therapy (ST) often favor less costly generic pain medications over pregabalin...
August 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28837075/botulinum-toxin-for-the-treatment-of-neuropathic-pain
#19
REVIEW
JungHyun Park, Hue Jung Park
Botulinum toxin (BoNT) has been used as a treatment for excessive muscle stiffness, spasticity, and dystonia. BoNT for approximately 40 years, and has recently been used to treat various types of neuropathic pain. The mechanism by which BoNT acts on neuropathic pain involves inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerves. Recent journals have demonstrated that BoNT is effective for neuropathic pain, such as postherpetic neuralgia, trigeminal neuralgia, and peripheral neuralgia...
August 24, 2017: Toxins
https://www.readbyqxmd.com/read/28834546/pharmacokinetics-and-safety-of-a-single-oral-dose-of-mirogabalin-in-japanese-subjects-with-varying-degrees-of-renal-impairment
#20
Manabu Kato, Naoyuki Tajima, Takako Shimizu, Masahiro Sugihara, Kenichi Furihata, Kazuhiro Harada, Hitoshi Ishizuka
Mirogabalin (DS-5565) is a novel preferentially selective α2 δ-1 ligand being developed for the treatment of diabetic peripheral neuropathic pain and postherpetic neuralgia. The current multicenter open-label study determined the effect of varying degrees of renal impairment on the pharmacokinetics and safety of a single dose of mirogabalin 5 mg in Japanese subjects. A total of 30 subjects (6 subjects per renal function category [normal, mild, moderate, or severe impairment; and end-stage renal disease (ESRD)]) were enrolled and completed the study...
August 23, 2017: Journal of Clinical Pharmacology
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