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https://www.readbyqxmd.com/read/29151827/tumor-necrosis-factor-like-weak-inducer-of-apoptosis-regulates-quadriceps-muscle-atrophy-and-fiber-type-alteration-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#1
Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Sun
Background: In chronic obstructive pulmonary disease (COPD), weakness and muscle mass loss of the quadriceps muscle has been demonstrated to predict survival and mortality rates of patients. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), as a member of the TNF superfamily, has recently been identified as a key regulator of skeletal muscle wasting and metabolic dysfunction. So our aim was to study the role of TWEAK during quadriceps muscle atrophy and fiber-type transformation in COPD model rats and its possible pathway...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/29143982/tweak-fn14-interaction-induces-proliferation-and-migration-in-human-airway-smooth-muscle-cells-via-activating-the-nf-%C3%AE%C2%BAb-pathway
#2
Cuimin Zhu, Leguo Zhang, Zhiming Liu, Chen Li, Yajie Bai
Asthma, an increasingly common chronic disease among children, are characterized by airway remodeling, which is partly attributed to the proliferation and migration of airway smooth muscle cell (ASMC). The purpose of the present study was to investigate potential roles and mechanisms of the tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible molecule 14 (Fn14) axis on cell proliferation and migration in HASMCs. Compared to HASMCs from non-asthmatic patients, those from asthmatic patients showed elevated expression levels of both Fn14 and TWEAK...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29137708/smartphone-based-non-invasive-salivary-glucose-biosensor
#3
Anuradha Soni, Sandeep Kumar Jha
The present work deals with the development of a non-invasive optical glucose biosensor using saliva samples and a smartphone. The sensor was fabricated with a simple methodology by immobilization of Glucose oxidase enzyme along with a pH responsive dye on a filter paper based strip. The strip changes color upon reaction with glucose present in saliva and the color changes were detected using a smartphone camera through RGB profiling. This standalone biosensor showed good sensitivity and low interference while operating within 20 s response time...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29130664/-prediction-value-of-tweak-fn14-in-crohn-s-disease-with-intestinal-fibrosis
#4
Ting Xu, Yan Yang, Li Zhao, Dan-Dan Zhou, Yan Zhang
OBJECTIVE: To investigate the expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/ fibroblast growth factorinducible 14 (Fn14) in the serum and colon tissue of Crohn's disease (CD) and to elucidate whether the expression of TWEAK/Fn14 can be used as an indicator for intestinal fibrosis. METHODS: Blood samples from 67 CD patients and 33 healthy controls were collected to measure the level of TWEAK by ELISA. Meanwhile,colon samples from 29 CD patients received colectomy and the normal colon tissues from 15 patients with colon cancer were included...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29107125/degradation-of-extracellular-matrix-regulates-osteoblast-migration-a-microfluidic-based-study
#5
N Movilla, C Borau, C Valero, J M García-Aznar
Bone regeneration is strongly dependent on the capacity of cells to move in a 3D microenvironment, where a large cascade of signals is activated. To improve the understanding of this complex process and to advance in the knowledge of the role of each specific signal, it is fundamental to analyze the impact of each factor independently. Microfluidic-based cell culture is an appropriate technology to achieve this objective, because it allows recreating realistic 3D local microenvironments by taking into account the extracellular matrix, cells and chemical gradients in an independent or combined scenario...
October 26, 2017: Bone
https://www.readbyqxmd.com/read/29102620/levels-of-cytokines-in-serum-associate-with-development-of-hepatocellular-carcinoma-in-patients-with-hcv-infection-treated-with-direct-acting-antivirals
#6
Jose D Debes, Marjolein van Tilborg, Zwier M A Groothuismink, Bettina E Hansen, Julian Schulze Zur Wiesch, Johann von Felden, Robert J de Knegt, Andre Boonstra
Concern has arisen about development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our study included 13 patients who developed HCC within 18 months after treatment (3 with HCC recurrence and 10 with new HCC) and 10 patients who did not develop HCC (controls), within at least 24 months of treatment (median, 26 months)...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29096001/hybrids-and-horizontal-transfer-introgression-allows-adaptive-allele-discovery
#7
Roswitha Schmickl, Sarah Marburger, Sian Bray, Levi Yant
Evolution has devised countless remarkable solutions to diverse challenges. Understanding the mechanistic basis of these solutions provides insights into how biological systems can be subtly tweaked without maladaptive consequences. The knowledge gained from illuminating these mechanisms is equally important to our understanding of fundamental evolutionary mechanisms as it is to our hopes of developing truly rational plant breeding and synthetic biology. In particular, modern population genomic approaches are proving very powerful in the detection of candidate alleles for mediating consequential adaptations that can be tested functionally...
October 31, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29095436/rna-sequencing-based-comparative-analysis-of-human-hepatic-progenitor-cells-and-their-niche-from-alcoholic-steatohepatitis-livers
#8
An Ceulemans, Stefaan Verhulst, Matthias Van Haele, Olivier Govaere, Juan-Jose Ventura, Leo A van Grunsven, Tania Roskams
Hepatic progenitor cells (HPCs) are small cells with a relative large oval nucleus and a scanty cytoplasm situated in the canals of Hering that express markers of (immature) hepatocytes and cholangiocytes. HPCs are present in large numbers in alcoholic steatohepatitis (ASH), one of the leading causes of chronic liver disease. To date, the mechanisms responsible for proliferation and differentiation of human HPCs are still poorly understood and the role of HPCs in ASH development is unknown. In this study, we aimed to characterise human HPCs and their interactions with other cells through comparison, on both protein and RNA level, of HPC-enriched cell populations from adult human liver tissue using different isolation methods...
November 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29075649/enavatuzumab-a-humanized-anti-tweak-receptor-monoclonal-antibody-exerts-antitumor-activity-through-attracting-and-activating-innate-immune-effector-cells
#9
Shiming Ye, Melvin I Fox, Nicole A Belmar, Mien Sho, Debra T Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F Keller, Gary C Starling, Patricia A Culp
Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved in postulated mechanisms for its potent antitumor activity in xenograft models. The initial evidence for a role of effector cells was obtained in a subset of tumor xenograft mouse models whose response to enavatuzumab relied on the binding of Fc of the antibody to Fcγ receptor...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29068159/sputum-tweak-expression-correlates-with-severity-and-degree-of-control-in-noneosinophilic-childhood-asthma
#10
Soo Yeon Kim, Jong Deok Kim, In Suk Sol, Min Jung Kim, Mi Na Kim, Jung Yeon Hong, Hye Ran Kim, Yoon Hee Kim, Yong Ju Lee, Kyung Won Kim, Myung Hyun Sohn
BACKGROUND: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is known to play a role in the pathogenesis of various inflammatory diseases. However, no study has been performed on childhood asthma. METHODS: Ninety-five children with asthma and 78 controls aged 5-18 years were included. Sputum induction, pulmonary function test (PFT), and methacholine challenge test were performed. The subjects were divided into the eosinophilic airway (EA) and non-EA (NEA) groups based on sputum analysis and into the high and low TWEAK groups according to the TWEAK cutoff level (263...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29054986/phase-1-study-of-enavatuzumab-a-first-in-class-humanized-monoclonal-antibody-targeting-the-tweak-receptor-in-patients-with-advanced-solid-tumors
#11
Elaine T Lam, S Gail Eckhardt, Wells Messersmith, Antonio Jimeno, Cindy L O'Bryant, Ramesh K Ramanathan, Glen J Weiss, Manpreet Chadha, Abbie Oey, Han Ting Ding, Patricia A Culp, Stephan F Keller, Vivian Y Zhao, L Claire Tsao, Anil Singhal, Kyle D Holen, Daniel D Von Hoff
This phase I study evaluates the safety, maximum tolerated dose (MTD), pharmacokinetics (PK), pharmacodynamics, and preliminary anticancer activity of enavatuzumab, a humanized IgG1 antibody to the TWEAK receptor, in patients with advanced solid malignancies. Patients received escalating doses of enavatuzumab given intravenously over 60 minutes every 2 weeks. Blood was obtained for PK and biomarker assessment. Three patients were enrolled per dose level in a standard 3+3 design with response assessment by RECIST version 1...
October 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29038621/tweak-fn14-activation-participates-in-skin-inflammation
#12
REVIEW
Qilu Liu, Shengxiang Xiao, Yumin Xia
Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor-fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory responses of keratinocytes by activating nuclear factor-κB signals and enhancing the production of several cytokines, including interleukins, monocyte chemotactic protein-1, RANTES (regulated on activation, normal T cell expressed and secreted), and interferon gamma-induced protein 10...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29036533/gvolante-for-standardizing-completeness-assessment-of-genome-and-transcriptome-assemblies
#13
Osamu Nishimura, Yuichiro Hara, Shigehiro Kuraku
Motivation: Along with the increasing accessibility to comprehensive sequence information, such as whole genomes and transcriptomes, the demand for assessing their quality has been multiplied. To this end, metrics based on sequence lengths, such as N50, have become a standard, but they only evaluate one aspect of assembly quality. Conversely, analyzing the coverage of pre-selected reference protein-coding genes provides essential content-based quality assessment, but the currently available pipelines for this purpose, CEGMA and BUSCO, do not have a user-friendly interface to serve as a uniform environment for assembly completeness assessment...
November 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027228/high-mobility-group-box-1-protein-orchestrates-responses-to-tissue-damage-via-inflammation-innate-and-adaptive-immunity-and-tissue-repair
#14
REVIEW
Marco E Bianchi, Massimo P Crippa, Angelo A Manfredi, Rosanna Mezzapelle, Patrizia Rovere Querini, Emilie Venereau
A single protein, HMGB1, directs the triggering of inflammation, innate and adaptive immune responses, and tissue healing after damage. HMGB1 is the best characterized damage-associated molecular pattern (DAMP), proteins that are normally inside the cell but are released after cell death, and allow the immune system to distinguish between antigens that are dangerous or not. Notably, cells undergoing severe stress actively secrete HMGB1 via a dedicated secretion pathway: HMGB1 is relocated from the nucleus to the cytoplasm and then to secretory lysosomes or directly to the extracellular space...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29023448/structural-host-microbiota-interaction-networks
#15
REVIEW
Emine Guven-Maiorov, Chung-Jung Tsai, Ruth Nussinov
Hundreds of different species colonize multicellular organisms making them "metaorganisms". A growing body of data supports the role of microbiota in health and in disease. Grasping the principles of host-microbiota interactions (HMIs) at the molecular level is important since it may provide insights into the mechanisms of infections. The crosstalk between the host and the microbiota may help resolve puzzling questions such as how a microorganism can contribute to both health and disease. Integrated superorganism networks that consider host and microbiota as a whole-may uncover their code, clarifying perhaps the most fundamental question: how they modulate immune surveillance...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28973884/super-swelled-lyotropic-single-crystals
#16
Hojun Kim, Ziyuan Song, Cecilia Leal
Lipids self-assemble into diverse supramolecular structures that exhibit thermotropic and/or lyotropic behavior. Lyotropic mesophases, where membranes conform to periodic minimal surfaces dividing two nonpenetrating aqueous subspaces, are arguably one of the most intriguing phases of lipid materials. Traditional 3D bicontinuous cubic lipid materials appear as a polycrystal of varying degrees of order. When exposed to water, the properties of the molecular building blocks of the membrane determine specific swelling limits setting the lattice dimensions at about 15 nm...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28934756/tumor-necrosis-factor-receptor-mediates-fibroblast-growth-factor-inducible-14-signaling
#17
REVIEW
Xuening Wang, Shengxiang Xiao, Yumin Xia
Tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) engages its sole receptor, fibroblast growth factor-inducible 14 (Fn14), which participates in various inflammatory and immunologic processes. TWEAK/Fn14 interaction induces different cell fates depending on the local microenvironment, which correlates with certain expression profiles of TNF receptors (TNFR). The predominant expression of TNFR1 or TNFR2 facilitates cell death or proliferation, respectively, on TWEAK/Fn14 activation. TNFR-associated factors (TRAF) interact with Fn14, cellular inhibitor of apoptosis protein (cIAP)-1, and TNFR, consequently transducing signals from TWEAK to downstream cytokines and cell cycle mediators...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28932628/a-novel-in-silico-framework-to-improve-mhc-i-epitopes-and-break-the-tolerance-to-melanoma
#18
Cristian Capasso, Aniket Magarkar, Victor Cervera-Carascon, Manlio Fusciello, Sara Feola, Martin Muller, Mariangela Garofalo, Lukasz Kuryk, Siri Tähtinen, Lucio Pastore, Alex Bunker, Vincenzo Cerullo
Tolerance toward tumor antigens, which are shared by normal tissues, have often limited the efficacy of cancer vaccines. However, wild type epitopes can be tweaked to activate cross-reactive T-cell clones, resulting in antitumor activity. The design of these analogs (i.e., heteroclitic peptides) can be difficult and time-consuming since no automated in silico tools are available. Hereby we describe the development of an in silico framework to improve the selection of heteroclitic peptides. The Epitope Discovery and Improvement System (EDIS) was first validated by studying the model antigen SIINFEKL...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28928299/a-study-on-knowledge-attitude-and-practice-regarding-mental-health-illnesses-in-amdanga-block-west-bengal
#19
Rivu Basu, Arkaprabha Sau, Soham Saha, Souren Mondal, Pradip Kumar Ghoshal, Sourav Kundu
BACKGROUND: The discourse of mental health is getting its due attention after all these years in India. A major threat to the mental health system is the demand side factors, namely, knowledge, attitude, and practice (KAP) of the general population toward this. In spite of growing concern regarding mental health in India, this kind of study to assess the mental health status has been very few in India, more so in West Bengal. OBJECTIVES: With this background, this study was carried out with the objectives to validate the Community Attitude to Mental Illness (CAMI), to assess the different sociodemographic factors among the study population, to assess the KAP regarding mental illness among the study population...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28927419/tumor-necrosis-factor-superfamily-ligand-mrna-expression-profiles-differ-between-humans-and-mice-during-homeostasis-and-between-various-murine-kidney-injuries
#20
Satish Kumar Devarapu, Julia Felicitas Grill, Junhui Xie, Marc Weidenbusch, Mohsen Honarpisheh, Volker Vielhauer, Hans-Joachim Anders, Shrikant R Mulay
BACKGROUND: Several tumour necrosis factor (TNF) based therapeutics have already been approved for human use and several others are emerging. Therefore, we determined the mRNA expression levels of the TNF superfamily ligands (TNFSF) - e.g. TNF-α, lymphotoxin (LT)-α, LT-β, Fas-L (CD95-L), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related weak inducer of apoptosis (TWEAK), 4-1BBL, OX40-L (CD252) and amyloid precursor protein (APP) in healthy human and mouse solid organs. METHODS: We used quantitative real time-PCR to analyse mRNA expression levels of TNFSF ligands...
September 19, 2017: Journal of Biomedical Science
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