keyword
MENU ▼
Read by QxMD icon Read
search

Tweak

keyword
https://www.readbyqxmd.com/read/28535173/invited-commentary-self-control-is-a-virtue
#1
C R Weinberg
The case-crossover design, introduced in 1991 by Malcolm Maclure (Am J Epidemiol. 1991;133(2):144-153), provided a precise and powerful tool for studying short-term effects of transient triggering exposures on abrupt outcomes like myocardial infarction. The design is an example of "self-control." One compares case-time intervals that include experiences that came just before the health event with control-time intervals that capture comparable experiences more remote from the event. Methodologists have since tweaked the general approach, recognizing issues that need to be considered to guard against time-driven confounders...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28530223/tweak-mediates-inflammation-in-experimental-atopic-dermatitis-and-psoriasis
#2
Daniel Sidler, Ping Wu, Rana Herro, Meike Claus, Dennis Wolf, Yuko Kawakami, Toshiaki Kawakami, Linda Burkly, Michael Croft
Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune responses, but some proteins might be critical to both diseases. Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in defective maintenance of AD-specific T helper type 2 (Th2) and psoriasis-specific Th17 cells in the skin, and impaired expression of disease-characteristic chemokines and cytokines, such as CCL17 and TSLP in AD, and CCL20 and IL-19 in psoriasis. The TWEAK receptor, Fn14, is upregulated in keratinocytes and dermal fibroblasts, and TWEAK induces these cytokines and chemokines alone and in synergy with the signature T helper cytokines of either disease, IL-13 and IL-17...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28512793/5-azacytidine-mediated-hmsc-behaviour-on-electrospun-scaffolds-for-skeletal-muscle-regeneration
#3
Ines Fasolino, Vincenzo Guarino, Valentina Cirillo, Luigi Ambrosio
Incomplete regeneration after trauma or muscular dysfunction is a common problem in muscle replacement therapies. Recent approaches in tissue engineering allow for the replication of skeletal muscle structure and function in vitro and in vivo by molecular therapies and implantable scaffolds which properly address muscle cells towards myotube differentiation and maturation. Here, we investigate the in vitro response of human Mesenchymal Stem Cells (hMSC) on electrospun fibres made of Polycaprolactone (PCL) in the presence of 5-azacytidine (5-AZA) to evaluate how fibrous network may influence the therapeutic effect of drug during in vitro myogenesis...
May 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28497873/an-online-education-approach-to-population-health-in-a-global-society
#4
Queen Utley-Smith
BACKGROUND: Health professions education content must keep pace with the ever-evolving and changing health care system. Population-based health care is advocated as a way to improve health outcomes, particularly in a technologically advanced health system like the United States. At the same time, global health knowledge is increasingly valued in health professions education, including nursing. AIMS: This article describes the design and implementation of an online population health course with a global viewpoint intended to accommodate the need for improved knowledge and skill application for graduate nurses...
May 12, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28473714/a-2-oxa-spiro-5-4-decane-scaffold-displays-neurotrophic-neurogenic-and-anti-neuroinflammatory-activities-with-high-potential-for-development-as-a-versatile-cns-therapeutic
#5
Pranav Chintamani Joshi, Ramesh Samineni, Dwaipayan Bhattacharya, Bommana Raghunath Reddy, Lenin Veeraval, Tapatee Das, Swati Maitra, Abhipradnya Bipin Wahul, Shailaja Karri, Srihari Pabbaraja, Goverdhan Mehta, Arvind Kumar, Sumana Chakravarty
Following our recent discovery of a new scaffold exhibiting significant neurotrophic and neurogenic activities, a structurally tweaked analogue, embodying a 2-oxa-spiro [5.4]decane framework, has been conceptualised and found to be more potent and versatile. It exhibits enhanced neurotrophic and neurogenic action in in vitro, ex vivo and in vivo models and also shows robust neuroprotection in mouse acute cerebral stroke model. The observed attributes are traceable to the predominant activation of the TrkB-PI3K-AKT-CREB pathway...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470609/generation-of-recombinant-n-linked-glycoproteins-in-e-coli
#6
Benjamin Strutton, Stephen R P Jaffé, Jagroop Pandhal, Phillip C Wright
The production of N-linked recombinant glycoproteins is possible in a variety of biotechnology host cells, and more recently in the bacterial workhorse, Escherichia coli. This methods chapter will outline the components and procedures needed to produce N-linked glycoproteins in E. coli, utilizing Campylobacter jejuni glycosylation machinery, although other related genes can be used with minimal tweaks to this methodology. To ensure a successful outcome, various methods will be highlighted that can confirm glycoprotein production to a high degree of confidence, including the gold standard of mass spectrometry analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28455790/advanced-glycation-end-products-attenuate-the-function-of-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-to-regulate-the-inflammatory-response
#7
Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Hideo Takahashi, Masahiro Nishibori, Shuji Mori
Advanced glycation end products (AGEs) are formed from the non-enzymatic glycation reaction of reducing sugars or their metabolites with the free amino groups of several biomolecules and are known to play pathophysiological roles in various inflammatory diseases. In an earlier study, it was suggested that tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has a unique role to regulate the tumor necrosis factor α (TNFα)-induced inflammatory response. In this study, we investigated the effect of the AGEs-TWEAK interaction on proinflammatory signaling responses in endothelial cells and the influence of AGEs on the cellular function of TWEAK in the inflammatory process...
April 28, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28455246/fn14%C3%A2-trail-fusion-protein-is-oligomerized-by-tweak-into-a-superefficient-trail-analog
#8
Tatyana B Prigozhina, Fanny Szafer, Alexandra Aronin, Kobi Tzdaka, Shira Amsili, Efi Makdasi, Noam Shani, Michal Dranitzki Elhalel
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) demonstrates specific anti-cancer activity, but insufficient efficacy in patients. A fusion protein Fn14·TRAIL, that combines soluble TRAIL molecule with a specific TWEAK receptor Fn14, is a better apoptosis-inducer for hepatocellular carcinomas than soluble TRAIL. However, Fn14·TRAIL does not effectively induce apoptosis in tumors of the lymphoid origin. As malignant cell apoptosis is strongly enhanced by secondary oligomerization of TRAIL, we tested the hypothesis that soluble Fn14·TRAIL can be oligomerized and become more active by adding TWEAK, a cytokine secreted in the tumor environment...
April 25, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28455000/ethylglucuronide-in-the-urine-as-a-marker-of-alcohol-consumption-during-pregnancy-comparison-with-four-alcohol-screening-questionnaires
#9
Giampiero Ferraguti, Paola Ciolli, Valentina Carito, Gemma Battagliese, Rosanna Mancinelli, Stefania Ciafrè, Paola Tirassa, Rosaria Ciccarelli, Alessia Cipriani, Marisa Patrizia Messina, Marco Fiore, Mauro Ceccanti
Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strategies to reveal alcohol use have been planning including the use of screening questionnaires as the AUDIT-C, T-ACE and TWEAK. The present study aims to investigate in pregnant women the specificity and predictive value of the AUDIT-C, T-ACE and TWEAK plus a food diary in use in Sapienza University Hospital compared with the results of urine EtG measurement...
April 25, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28447667/tweak-blockade-decreases-atherosclerotic-lesion-size-and-progression-through-suppression-of-stat1-signaling-in-diabetic-mice
#10
Valvanera Fernández-Laso, Cristina Sastre, Nerea Méndez-Barbero, Jesús Egido, Jose L Martín-Ventura, Carmen Gómez-Guerrero, Luis M Blanco-Colio
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK/Tnfsf12) is a cytokine implicated in different steps associated with vascular remodeling. However, the role of TWEAK under hyperglycemic conditions is currently unknown. Using two different approaches, genetic deletion of Tnfsf12 and treatment with a TWEAK blocking mAb, we have analyzed the effect of TWEAK inhibition on atherosclerotic plaque progression and stability in streptozotocin-induced diabetic ApoE deficient mice. Genetic inactivation of Tnfsf12 reduced atherosclerosis extension and severity in diabetic ApoE deficient mice...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428709/disruption-of-the-tweak-fn14-pathway-prevents-5-fluorouracil-induced-diarrhea-in-mice
#11
Takuhito Sezaki, Yuki Hirata, Teruki Hagiwara, Yuki I Kawamura, Tadashi Okamura, Rieko Takanashi, Kenta Nakano, Miwa Tamura-Nakano, Linda C Burkly, Taeko Dohi
AIM: To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil (5-FU)-induced diarrhea. METHODS: Diarrhea was induced in wild-type (WT), Fn14 knockout (KO), and IL-13 receptor (IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinoma-bearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28427384/imbalanced-target-prediction-with-pattern-discovery-on-clinical-data-repositories
#12
Tak-Ming Chan, Yuxi Li, Choo-Chiap Chiau, Jane Zhu, Jie Jiang, Yong Huo
BACKGROUND: Clinical data repositories (CDR) have great potential to improve outcome prediction and risk modeling. However, most clinical studies require careful study design, dedicated data collection efforts, and sophisticated modeling techniques before a hypothesis can be tested. We aim to bridge this gap, so that clinical domain users can perform first-hand prediction on existing repository data without complicated handling, and obtain insightful patterns of imbalanced targets for a formal study before it is conducted...
April 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28423824/querying-archetype-based-electronic-health-records-using-hadoop-and-dewey-encoding-of-openehr-models
#13
Erik Sundvall, Fang Wei-Kleiner, Sergio M Freire, Patrick Lambrix
Archetype-based Electronic Health Record (EHR) systems using generic reference models from e.g. openEHR, ISO 13606 or CIMI should be easy to update and reconfigure with new types (or versions) of data models or entries, ideally with very limited programming or manual database tweaking. Exploratory research (e.g. epidemiology) leading to ad-hoc querying on a population-wide scale can be a challenge in such environments. This publication describes implementation and test of an archetype-aware Dewey encoding optimization that can be used to produce such systems in environments supporting relational operations, e...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28411440/tweak-fn14-promotes-pro-inflammatory-cytokine-secretion-in-hepatic-stellate-cells-via-nf-%C3%AE%C2%BAb-stat3-pathways
#14
Aixiu Wang, Feng Zhang, Hui Xu, Mingcui Xu, Yu Cao, Chen Wang, Yuanyuan Xu, Min Su, Ming Zhang, Yuzheng Zhuge
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) have been associated with liver disease. Hepatic stellate cells (HSCs) play a critical role in the hepatic wound-healing response after liver injury, but there is little information available on the role of the TWEAK/Fn14 pathway in human HSCs. In this study, we explored the role of TWEAK/Fn14 in activated human HSCs. The LX-2 cells were treated with TWEAK, and the expression of pro-inflammatory cytokines was assayed by enzyme-linked immunosorbent assay (ELISA) and real-time PCR (RT-PCR)...
April 12, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28391869/amplification-of-resonance-rayleigh-scattering-of-gold-nanoparticles-by-tweaking-into-nanowires-bio-sensing-of-%C3%AE-tocopherol-by-enhanced-resonance-rayleigh-scattering-of-curcumin-capped-gold-nanowires-through-non-covalent-interaction
#15
Riham El Kurdi, Digambara Patra
Tuning optical properties by controlling size and shape of the metallic nanoparticles has been of great interest to design novel bio-sensing techniques. Here, as a first example we illustrate that resonance Rayleigh scattering (RRS) signal of Au nanoparticles (NPs) can be amplified >10-fold by growing into Au nanowires (NWs). These thin and long NWs of ~20-25nm diameter and >1µm length can be achieved by suitably manipulating the temperature during green synthesis using curcumin. Interestingly, mixture of Au NWs and NPs or shorter NWs gives a moderate increase in RRS signal suggesting formation of longer NWs is crucial for optimal enhancement of RRS signal...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28390578/preventing-food-allergies-with-tweaks-to-the-infant-diet-a-practical-reality
#16
Julie Wang, Marion Groetch
No abstract text is available yet for this article.
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28390291/soluble-tweak-and-atheromatosis-progression-in-patients-with-chronic-kidney-disease
#17
Valvanera Fernández-Laso, Nerea Méndez-Barbero, Jose M Valdivielso, Angels Betriu, Elvira Fernández, Jesús Egido, Jose L Martín-Ventura, Luis M Blanco-Colio
BACKGROUND AND AIMS: Circulating soluble TNF-like weak inducer of apoptosis (sTWEAK) concentrations are related to the presence of chronic kidney disease (CKD) and cardiovascular disease (CVD). However, there are no data regarding the potential association between sTWEAK and atheromatosis progression in patients free of cardiovascular events. METHODS: Soluble TWEAK serum concentration was measured in 702 CKD patients without any previous CV event from The National Observatory of Atherosclerosis in Nephrology (NEFRONA) Study...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28383766/tweak-promotes-migration-and-invasion-in-mefs-through-a-mechanism-dependent-on-erks-activation-and-fibulin-3-down-regulation
#18
Celia Sequera, Ana Vázquez-Carballo, María Arechederra, Sonia Fernández-Veledo, Almudena Porras
TWEAK regulates multiple physio-pathological processes in fibroblasts such as fibrosis. It also induces migration and invasion in tumors and it can activate p38 MAPK in various cell types. Moreover, p38α MAPK promotes migration and invasion in several cancer cells types and in mouse embryonic fibroblasts (MEFs). However, it remains unknown if TWEAK could promote migration in fibroblasts and whether p38α MAPK might play a role. Our results reveal that TWEAK activates ERKs, Akt and p38α/β MAPKs and reduces secreted Fibulin 3 in MEFs...
April 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28351660/tweak-fn14-activation-contributes-to-the-pathogenesis-of-bullous-pemphigoid
#19
Yale Liu, Lingling Peng, Liang Li, Chengfei Liu, Xiao Hu, Shengxiang Xiao, Yumin Xia
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in various cellular effects by engaging its receptor of fibroblast growth factor inducible 14 (Fn14). Increased levels of soluble TWEAK are associated with systemic autoimmunity in patients with lupus erythematosus, rheumatoid arthritis or dermatomyositis. However, the role of TWEAK in bullous pemphigoid (BP) remains unknown. In this study, we found an elevated serum level of TWEAK and a positive correlation between serum TWEAK and anti-BP180 antibodies...
March 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28336619/tweak-makes-u-s-nukes-more-precise-and-deadlier
#20
Eliot Marshall
No abstract text is available yet for this article.
March 24, 2017: Science
keyword
keyword
48698
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"