keyword
MENU ▼
Read by QxMD icon Read
search

Tweak

keyword
https://www.readbyqxmd.com/read/28809783/role-of-omentin-vaspin-cardiotrophin-1-tweak-and-nov-ccn3-in-obesity-and-diabetes-development
#1
REVIEW
Xavier Escoté, Saioa Gómez-Zorita, Miguel López-Yoldi, Iñaki Milton-Laskibar, Alfredo Fernández-Quintela, J Alfredo Martínez, María J Moreno-Aliaga, María P Portillo
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28800513/serum-tnf-related-weak-inducer-of-apoptosis-tweak-and-tnf-related-apoptosis-inducing-ligand-trail-levels-of-patients-with-bipolar-disorder-in-manic-episode-in-remission-and-healthy-controls
#2
Merve Cingi Yirün, Onur Yirün, Kübranur Ünal, Rabia Nazik Yüksel, Neslihan Altunsoy, Elif Tatlidil Yaylaci, Makbule Çiğdem Aydemir, Erol Göka
TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) are members of TNF superfamily, which has various roles in immunologic and inflammatory reactions in the organism. Pathophysiology in bipolar disorder is still under investigation and altered serum levels of cytokines are often encountered. Aim of this study is to detect serum TWEAK and TRAIL levels of patients with bipolar disorder and healthy controls. For this purpose, 55 patients with bipolar disorder -27 manic episode (ME), 28 remission (RE) and 29 healthy controls (HC) were included...
August 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28783937/plasma-levels-of-tumor-necrosis-factor-superfamily-molecules-are-increased-in-bipolar-disorder
#3
Izabela G Barbosa, Gabriela Neves Vaz, Natalia Pessoa Rocha, Rodrigo Machado-Vieira, Marcio Rogerio Diniz Ventura, Rodrigo B Huguet, Moises E Bauer, Michael Berk, Antônio L Teixeira
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28774811/the-interaction-of-dendrimer-doxorubicin-conjugates-with-a-model-pulmonary-epithelium-and-their-cosolvent-free-pseudo-solution-formulations-in-pressurized-metered-dose-inhalers
#4
Qian Zhong, Bruno V Humia, Alisha R Punjabi, Francine F Padilha, Sandro R P da Rocha
Oral inhalation (OI) of nano-chemotherapeutics holds great potentials in the treatment of lung cancers as it enables direct targeting of drugs to lung tissues, spatial and temporal control of drug release, and decrease in drug-associated systemic and local lung toxicity. Therefore, the design of chemistry of the nanocarriers and their OI formulations for chemotherapeutics delivery to the peripheral lungs and extrapulmonary tissues of relevance such as lymph nodes, may thus afford new opportunities for treating such relevant diseases...
July 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28757496/pharmacy-testing-and-the-language-of-truth-in-renaissance-italy
#5
Valentina Pugliano
This article examines the role of testing and innovation in sixteenthcentury Italian pharmacy. I argue that apothecaries were less concerned with testing drugs for efficacy or creating novel products than with reactivating an older Mediterranean pharmacological tradition and studying the materials on which it relied. Their practice was not driven by radical experimentation but by a "culture of tweaking"-of minute operational changes to existing recipes and accommodation of their textual variants-which was rooted in the guild economy fostering incremental over radical innovation and in a humanist reevaluation of past autorities...
2017: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/28756321/enhanced-nucleation-of-diamond-on-three-dimensional-tools-via-stabilized-colloidal-nanodiamond-in-electrostatic-self-assembly-seeding-process
#6
Tao Wang, Stephan Handschuh-Wang, Songquan Zhang, Xuechang Zhou, Yongbing Tang
Nanocrystalline diamond particles are promising candidates for copious applications in materials science, biology and electronics. In this work, diamond nucleation density was unprecedentedly enhanced via a non-invasive electrostatic self-assembly seeding approach. By addition of glutamic acid to the nanodiamond seeding solution, the positively charged amino-group of glutamic acid, which is adsorbed on nanodiamond particles, enhances the adsorption on negative charged cemented carbide substrate. The highest nucleation density (1...
July 11, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28755900/assessment-of-urinary-tweak-levels-in-mexican-patients-with-untreated-lupus-nephritis-an-exploratory-study
#7
Fabiola Reyes-Martínez, Monserrat Pérez-Navarro, Adrián Rodríguez-Matías, Virgilia Soto-Abraham, Gabriela Gutierrez-Reyes, Zaira Medina-Avila, Rafael Valdez-Ortiz
OBJECTIVES: Urinary levels of TWEAK (uTWEAK) may be correlated with the degree of lupus nephritis (LN) activity. Our objective was to determine the sensitivity and specificity of uTWEAK in Mexican patients with untreated active lupus nephritis. METHODS: An exploratory study was performed; four groups of patients were analyzed as follows: 1) patients with systemic lupus erythematosus (SLE) without renal activity (SLE-LN), 2) patients with SLE with renal activity (SLE+LN), 3) patients with other types of glomerulopathy (glomerulonephritis, GMN), 4) and healthy patients (controls)...
July 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28748592/influence-of-narrowband-ultraviolet-b-phototherapy-on-serum-tumour-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-in-patients-with-psoriasis
#8
H Myśliwiec, P Kiluk, P Myśliwiec, B Żelazowska-Rutkowska, A Baran, I Flisiak
Psoriasis is characterized by keratinocyte resistance to apoptosis. We recently demonstrated an increase in serum tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in patients after topical treatment for psoriasis. We decided to verify whether narrowband ultraviolet B (NB-UVB) has a similar effect. Serum concentration of TWEAK was estimated in patients with exacerbated plaque psoriasis treated with NB-UVB. Baseline TWEAK levels were similar in patients with psoriasis and healthy controls, and Psoriasis Area and Severity Index (PASI) correlated inversely with TWEAK levels...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28741358/combining-de-novo-peptide-sequencing-algorithms-a-synergistic-approach-to-boost-both-identifications-and-confidence-in-bottom-up-proteomics
#9
Bernhard Blank-Landeshammer, Laxmikanth Kollipara, Karsten Biß, Markus Pfenninger, Sebastian Malchow, Konstantin Shuvaev, René P Zahedi, Albert Sickmann
Complex mass spectrometry based proteomics datasets are mostly analyzed by protein database-searches. While this approach performs considerably well for sequenced organisms, direct inference of peptide sequences from tandem mass spectra, i.e. de novo peptide sequencing, oftentimes is the only way to obtain information when protein databases are absent. However, available algorithms suffer from drawbacks such as lack of validation and often high rates of false positive hits (FP). Here we present a simple method of combining results from commonly available de novo peptide sequencing algorithms, which in conjunction with minor tweaks in data acquisition ensues lower empirical FDR compared to the analysis using single algorithms...
July 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28726947/on-the-critical-role-of-the-substrate-the-adsorption-behaviour-of-tetrabenzoporphyrins-on-different-metal-surfaces
#10
Liang Zhang, Michael Lepper, Michael Stark, Teresa Menzel, Dominik Lungerich, Norbert Jux, Wolfgang Hieringer, Hans-Peter Steinrück, Hubertus Marbach
The adsorption behaviour of 2H-5,10,15,20-tetraphenyltetrabenzoporphyrin (2HTPTBP) on different metal surfaces, i.e., Ag(111), Cu(111), Cu(110), and Cu(110)-(2 × 1)O was investigated by scanning tunnelling microscopy at room temperature. The adsorption of 2HTPTBP on Ag(111) leads to the formation of a well-ordered two-dimensional (2D) island structure due to the mutual stabilization through the intermolecular π-π stacking and T-type-like interactions of phenyl and benzene substituents of neighboring molecules...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28684863/bcl3-a-regulator-of-nf-%C3%AE%C2%BAb-inducible-by-tweak-in-acute-kidney-injury-with-anti-inflammatory-and-antiapoptotic-properties-in-tubular-cells
#11
Jonay Poveda, Ana B Sanz, Susana Carrasco, Marta Ruiz-Ortega, Pablo Cannata-Ortiz, Maria D Sanchez-Niño, Alberto Ortiz
Acute kidney injury (AKI) is characterized by tubular cell death and interstitial inflammation. TWEAK promotes experimental kidney injury and activates the transcription factor NF-κB, a key regulator of genes involved in cell survival and inflammatory response. In search of potential therapeutic targets for AKI, we compared a transcriptomics database of NF-κB-related genes from murine AKI-kidneys with a transcriptomics database of TWEAK-stimulated cultured tubular cells. Four out of twenty-four (17%) genes were significantly upregulated (false discovery rate, FDR<0...
July 7, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28684712/decaf-discrimination-comparison-alignment-tool-for-2d-pharmacophores
#12
Marta M Stepniewska-Dziubinska, Piotr Zielenkiewicz, Pawel Siedlecki
Comparison of small molecules is a common component of many cheminformatics workflows, including the design of new compounds and libraries as well as side-effect predictions and drug repurposing. Currently, large-scale comparison methods rely mostly on simple fingerprint representation of molecules, which take into account the structural similarities of compounds. Methods that utilize 3D information depend on multiple conformer generation steps, which are computationally expensive and can greatly influence their results...
July 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28674522/desynchronization-of-circadian-clocks-in-cancer-a-metabolic-and-epigenetic-connection
#13
REVIEW
Kiran Padmanabhan, Marc Billaud
Circadian clocks are innate oscillators that drive daily rhythms in metabolism, physiology, and behavior. 24-h rhythms in gene expression, driven by core clock transcription factors, reflect the epigenetic state of the cell, which in turn is dictated by the metabolic environment. Cancer cells alter their metabolic state and gene expression and therefore are likely to tweak circadian clock function in their favor. Over the past decade, we have witnessed an extraordinary increase in systems-level studies that suggest intricate mechanistic links between the cellular metabolome and the circadian epigenome...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28661755/the-final-rule-when-the-rubber-meets-the-road
#14
P Pearl O'Rourke
The Common Rule originally issued in 1991 and last amended in 2005 is scheduled to be replaced on January 19, 2018 by a revised Common Rule (the final rule). The goal of the revisions is to modernize and improve applicability of the rule to a research landscape that has dramatically changed since 1991. Translating these changes into action will require comprehensive understanding of the final rule and detailed implementation planning by Human Research Protection Programs. This paper presents select changes that require substantial attention; including for example: expansion of the exempt category, changes to continuing review requirements, changes to the informed consent form and the use of single IRBs for domestic multi-site research...
July 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28640637/designing-transmitter-ligands-that-mediate-energy-transfer-between-semiconductor-nanocrystals-and-molecules
#15
Zhiyuan Huang, Ming L Tang
Molecular control of energy transfer is an attractive proposition because it allows chemists to synthetically tweak various kinetic and thermodynamic factors. In this Perspective, we examine energy transfer between semiconductor nanocrystals (NCs) and π-conjugated molecules, focusing on the transmitter ligand at the organic-inorganic interface. Efficient transfer of triplet excitons across this interface allows photons to be directed for effective use of the entire solar spectrum. For example, a photon upconversion system composed of semiconductor NCs as sensitizers, bound organic ligands as transmitters, and molecular annihilators has the advantage of large, tunable absorption cross sections across the visible and near-infrared wavelengths...
July 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28639899/tweak-fn14-signaling-in-tumors
#16
REVIEW
Guanglei Hu, Weihui Zeng, Yumin Xia
TWEAK (tumor necrosis factor-related weak inducer of apoptosis), a member of the tumor necrosis factor superfamily, acts on cells by binding to its only receptor named Fn14 (fibroblast growth factor-inducible 14). Their engagement activates a number of intracellular signal transduction cascades and consequently leads to cell death, proliferation, migration, or survival depending on the cellular contexts. Studies have indicated that the expression of TWEAK and Fn14 is upregulated in many solid tumors compared with healthy tissues...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28636775/role-of-the-tumour-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-fibroblast-growth-factor-inducible-14-fn14-axis-in-autoimmune-thyroid-disease
#17
Shiqiao Peng, Xiaohui Yu, Xuemin Zhao, Xinyi Wang, Xuren Sun, Cheng Han, Zhongyan Shan, Chenyan Li, Weiping Teng
BACKGROUND: TNF-like weak inducer of apoptosis (TWEAK), its receptor fibroblast growth factor-inducible 14 (Fn14) and its scavenger receptor CD163 (sCD163) have known associations with many autoimmune diseases. However, the role of the TWEAK axis in autoimmune thyroid disease (AITD) remains unclear. Therefore, the aim of this study was to investigate the role of the TWEAK-Fn14 axis in the pathogenesis of AITD. METHODS: Serum levels of soluble TWEAK (sTWEAK) and sCD163 were measured in 38 patients with Graves' disease (GD), 40 patients with Hashimoto's thyroiditis (HT), and 40 healthy controls (HCs)...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28620393/tweak-fn14-activation-participates-in-ro52-mediated-photosensitization-in-cutaneous-lupus-erythematosus
#18
Yale Liu, Meifeng Xu, Xiaoyun Min, Kunyi Wu, Ting Zhang, Ke Li, Shengxiang Xiao, Yumin Xia
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) binds to its sole receptor fibroblast growth factor-inducible 14 (Fn14), participating in various inflammatory responses. Recently, TWEAK/Fn14 activation was found prominent in the lesions of cutaneous lupus erythematosus (CLE). This study was designed to further reveal the potential role of this pathway in Ro52-mediated photosensitization. TWEAK, Fn14, and Ro52 were determined in the skin lesions of patients with CLE. Murine keratinocytes received ultraviolet B (UVB) irradiation or plus TWEAK stimulation and underwent detection for Ro52 and proinflammatory cytokines...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28619231/endoplasmic-reticulum-chaperones-tweak-the-mitochondrial-calcium-rheostat-to-control-metabolism-and-cell-death
#19
REVIEW
Tomas Gutiérrez, Thomas Simmen
The folding of secretory proteins is a well-understood mechanism, based on decades of research on endoplasmic reticulum (ER) chaperones. These chaperones interact with newly imported polypeptides close to the ER translocon. Classic examples for these proteins include the immunoglobulin binding protein (BiP/GRP78), and the lectins calnexin and calreticulin. Although not considered chaperones per se, the ER oxidoreductases of the protein disulfide isomerase (PDI) family complete the folding job by catalyzing the formation of disulfide bonds through cysteine oxidation...
May 31, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28612578/-expression-of-tweak-fn14-in-pancreatic-cancer
#20
Ai-Lin Wei, Qiang Guo, Shu Gong
OBJECTIVES: To investigate the effect of tumor necrosis factor -related weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) on the proliferation and growth of pancreatic cancer. METHODS: Human pancreatic cancer (50 cases), chronic pancreatitis (40 cases) and normal pancreatic tissues (30 cases) were collected in West China Hospital from January 2012 to December 2013. TWEAK and Fn14 expressions in these tissues were checked with hematoxylin-eosin (HE) staining and immunohistochemistry method...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
keyword
keyword
48698
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"