Mahwish Farrukh, Muhammad Ashar Ali, Madiha Naveed, Rooma Habib, Huda Khan, Tooba Kashif, Hina Zubair, Memoona Saeed, Sigmone K Butt, Rabiya Niaz, Ishan Garg, Aqsa Fatima, Wajeeha Aiman
Renal cell carcinoma (RCC) is the most common kidney cancer in adults (approximately 90%), and clear cell RCC (ccRCC) is the most frequent histologic subtype (approximately 75%). We reviewed the safety and efficacy of checkpoint inhibitors (CPIs) in ccRCC, identifying 5927 articles in PubMed, Embase, Cochrane, and Web of Science. Ten randomized control (N = 7765) and 10 non-randomized (N = 572) studies were included. Overall, 4819 patients treated with CPI combinations were compared with everolimus, sunitinib, or placebo...
April 4, 2023: Hematology/oncology and Stem Cell Therapy