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https://www.readbyqxmd.com/read/29917301/prevalence-and-prognostic-impact-of-non-cardiac-co-morbidities-in-heart-failure-outpatients-with-preserved-and-reduced-ejection-fraction-a-community-based-study
#1
Annamaria Iorio, Michele Senni, Giulia Barbati, Stephen J Greene, Stefano Poli, Elena Zambon, Concetta Di Nora, Giovanni Cioffi, Luigi Tarantini, Antonello Gavazzi, Gianfranco Sinagra, Andrea Di Lenarda
AIM: To assess adverse outcomes attributable to non-cardiac co-morbidities and to compare their effects by left ventricular ejection fraction (LVEF) group [LVEF <50% (heart failure with reduced ejection fraction, HFrEF), LVEF ≥50% (heart failure with preserved ejection fraction, HFpEF)] in a contemporary, unselected chronic heart failure population. METHODS AND RESULTS: This community-based cohort enrolled patients from October 2009 to December 2013. Adjusted hazard ratio (HR) and the population attributable fraction (PAF) were used to compare the contribution of 15 non-cardiac co-morbidities to adverse outcome...
June 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29917260/does-obesity-affect-the-outcomes-in-takotsubo-cardiomyopathy-analysis-of-the-nationwide-inpatient-sample-database-2010-2014
#2
Rupak Desai, Sandeep Singh, Maryam Baikpour, Hemant Goyal, Abhijeet Dhoble, Abhishek Deshmukh, Gautam Kumar, Rajesh Sachdeva
BACKGROUND: It is well known that obesity can lead to increased oxidative stress, which is one of the proposed mechanisms in the etiopathogenesis of Takotsubo Cardiomyopathy (TCM). However, it is unknown if the presence of obesity affects the outcomes in patients with TCM. METHODS: We queried the National Inpatient Sample database from 2010-2014 to identify adult patients who admitted with a principal diagnosis of TCM with and without obesity. We compared the categorical and continuous variables by Pearson's chi-square and Student's t-test respectively in propensity-score matched cohorts...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29917255/an-avatar-based-education-application-to-improve-patients-knowledge-of-and-response-to-heart-attack-symptoms-a-pragmatic-randomized-controlled-trial-protocol
#3
Jintana Tongpeth, Huiyun Du, Robyn Clark
AIM: To evaluate the effectiveness of an interactive, avatar based education application to improve knowledge of and response to heart attack symptoms in people who are at risk of a heart attack. BACKGROUND: Poor knowledge of heart attack symptoms is recognised as a significant barrier to timely medical treatment. Numerous studies have demonstrated that technology can assist in patient education to improve knowledge and self-care. DESIGN: A single-center, non-blinded, two parallel groups, pragmatic randomized controlled trial...
June 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29917214/safety-and-efficacy-of-tigecycline-in-complicated-and-uncomplicated-pelvic-inflammatory-disease
#4
A Perutelli, C Tascini, L Domenici, S Garibaldi, C Baroni, E Cecchi, M G Salerno
OBJECTIVE: Tigecycline is a glycylcycline antimicrobial structurally related to minocycline, with a wide spectrum of activity that includes anaerobes and typical and atypical microorganisms causing pelvic inflammatory disease (PID). This study aimed to evaluate efficacy and safety of tigecycline in complicated PID and un-complicated PID after the failure of first-line antibiotic therapy. PATIENTS AND METHODS: Between May 2014 and April 2016 at the 2nd Unit of Obstetrics and Gynecology, Santa Chiara Hospital of Pisa a pilot study on 20 women with mild/moderate PID after the failure of first-line antibiotic therapy and on 8 women with complicated PID was conducted...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917211/cardiocerebral-protective-effects-of-dexmedetomidine-as-anesthetic-in-colorectal-cancer-surgery
#5
X-L Yi, J-T Wang, C-Q Chu, Y-X Li, J-H Yin, S-L Liu
OBJECTIVE: To explore the cardiocerebral protective effect of dexmedetomidine as an anesthetic in colorectal cancer surgery. PATIENTS AND METHODS: A total of 246 colorectal cancer patients were enrolled in this retrospective analysis. Those patients were admitted to the Affiliated Hospital of Qingdao University and underwent surgery from July 2014 to July 2016. The patients were divided into observation group and control group according to the anesthetic used in surgery...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917201/a-study-on-correlations-of-procalcitonin-and-interleukin-6-with-viral-meningitis
#6
D-B Liu, H-P Zhang, K Yu, Q-B Lu, Z-F Zhu
OBJECTIVE: To study the change rules of inflammatory factors in cerebrospinal fluid (CSF) and serum of patients with viral meningitis. PATIENTS AND METHODS: 742 patients with suspected viral meningitis admitted to Department of Neurosurgery in our hospital from August 2012 to May 2016 were selected as research objects and retrospectively analyzed. 536 patients were diagnosed with viral meningitis by CSF with the lumbar puncture and brain computed tomography (CT), while the other 206 patients were diagnosed with non-infectious nervous system disease, as the control group...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917193/microrna-200c-suppresses-tumor-metastasis-in-oral-squamous-carcinoma-by-inhibiting-epithelial-mesenchymal-transition
#7
N-N Xie, Z-X Liu, C Wu, P-L Wang, G-T Song, Z Chen
OBJECTIVE: To examine the potential mechanisms implicating miR-200c and epithelial-mesenchymal transition (EMT) in oral squamous carcinoma (OSC). MATERIALS AND METHODS: 32 pairs of OSC tissue samples and matched para-carcinoma normal tissue from patients undergoing routine surgery in the Xuzhou Stomatological Hospital from 2014-2016. HOC313 cells were cultured and transfected with miR-200c mimics and scrambled mimics. Cell migration, invasion assays, Luciferase reporter assay, and Western blot assay were conducted...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917190/correlations-of-serum-vegf-and-mmp-2-levels-with-clm-in-crc-patients-and-effects-of-tace-on-their-expressions
#8
H Xu, Y-J Ren, K Liu, X-L Min, L Yang, Y Zhou, J Zheng, C Yang
OBJECTIVE: To investigate the correlations of serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) levels with colorectal liver metastasis (CLM) in patients with colorectal cancer (CRC), and determine the effects of transhepatic arterial chemoembolization (TACE) on their expressions. PATIENTS AND METHODS: A total of 110 CRC patients treated in the department of interventional radiology of our hospital from May 2013 to May 2016 were randomly enrolled...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917189/expressions-and-correlation-analysis-of-hif-1%C3%AE-survivin-and-vegf-in-patients-with-hepatocarcinoma
#9
Q-G Tian, Y-T Wu, Y Liu, J Zhang, Z-Q Song, W-F Gao, T-K Guo, C-H He, F-R Dai
OBJECTIVE: To investigate the expressions of HIF-1α, surviving, and VEGF in patients with hepatocarcinoma as well as the correlation analysis among them. PATIENTS AND METHODS: 65 patients, who were admitted to our hospital and diagnosed as hepatocarcinoma from January 2014 to October 2015, were selected as hepatocarcinoma group, while 50 healthy cases that do not have hepatocarcinoma were selected as normal control group. The expression levels of HIF-1α, surviving, and VEGF in hepatocarcinoma tissues of hepatocarcinoma group and normal liver tissues of control group were detected by immunohistochemical (SP) staining method; then, the correlation among them was explored...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917174/-disinfection-of-injection-ports-a-systematic-overview-of-optimal-scrub-time
#10
Lars Breimer, Håkan Geijer, Lars Berggren
Central venous catheter bloodstream infections are an important cause of hospital-acquired infection with increased morbidity, mortality and cost. The incidence varies between countries and even hospitals. Needleless connector hubs are used on virtually all intravascular devices and colonization of these is considered the cause of much of the postinsertion catheter-related infections through breaks in aseptic technique and failure to disinfect properly. This systematic review evaluated 165 search hits on hub disinfection practices with particular emphasis on the time of scrubbing the connector for 15 sec but also the impact of measures of education and compliance...
June 15, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29917172/-ten-years-with-the-who-checklist-for-safe-surgery-a-new-swedish-version-is-soon-to-be-introduced
#11
Pelle Gustafson, Anders Salomonsson, Per Svensson
The WHO Checklist for Safe Surgery has been in use in Swedish healthcare since 2009. Based on national and international experiences, we have developed the original checklist, with the aim to keep its strengths and remove the weaknesses. The most obvious difference is that each section of the original checklist has been split into a pure checklist and corresponding instructions. It is now also more obvious that the basis for the checklist is local guidelines/routines. It is primarily via these local guidelines/routines that local adaptations can be made...
June 19, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29917170/-safe-surgery-saves-lives-10-years-of-swedish-experience
#12
Jon Ahlberg, Karin Pukk-Härenstam
In June 2008, WHO launched the Safe Surgery Checklist. Nine months later a Swedish translation and adaptation was launched and distributed to virtually all Swedish hospitals. It gained rapid acceptance; in the fall of 2009, 73 hospitals reported that the checklist had been implemented and that its use was part of standard routine. A questionnaire in 2010 revealed that this was true for many but not all hospitals. International studies have shown that proper use of the checklist has positive effects on postoperative morbidity and mortality...
June 19, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29917158/introducing-rotavirus-vaccine-to-the-palestinian-territories-the-role-of-public-private-partnerships
#13
W P Rennert, M Hindiyeh, F M Abu-Awwad, H Marzouqa, A Ramlawi
Background: Introducing childhood immunization poses challenges in environments of societal fragility. The Palestinian territories (Pt) are considered 'fragile' because of their lack of political, economic and territorial sovereignty. Poverty is rife, infant mortality high, and diseases associated with overcrowding widespread. Under these circumstances the Rostropovich Vishneskaya Foundation (RVF) has assembled a network of public and private stakeholders to introduce a country-wide rotavirus immunization program...
June 15, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29917154/improving-the-safety-climate-in-hospitals-by-a-vignette-based-analysis-of-adverse-events-a-cluster-randomised-study
#14
Pauline Occelli, Jean-Luc Quenon, Marion Kret, Sandrine Domecq, Angélique Denis, Florence Delaperche, Olivier Claverie, Benjamin Castets-Fontaine, René Amalberti, Yves Auroy, Pierre Parneix, Philippe Michel
Objective: To assess the impact of a vignette-based analysis of adverse events (AEs) on the safety climate (SC) of care units. Design: Prospective, open, cluster (a unit) randomised controlled trial. Setting: Eighteen acute care units of seven hospitals in France. Participants: Healthcare providers who worked in the units. Intervention: Vignette-based analyses of AEs were conducted with unit's providers once per month for six consecutive months...
June 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917143/implementation-of-medication-related-indicators-of-potentially-preventable-hospitalizations-in-a-national-chronic-disease-management-program-for-older-patients-with-multimorbidity
#15
Gillian E Caughey, Jodie B Hillen, Stephanie Bacon, Nicholas Bullock, Virginia Bullock, Lisa Kalisch Ellett
Initial assessment: Older people are at increased risk of medication-related potentially preventable hospitalizations (MR-PPH) due to the presence of multiple chronic conditions (multimorbidity) and subsequent polypharmacy. Choice of solution: A pilot study was conducted, using evidence-based indicators to detect older patients in a chronic disease management program (CDMP) at risk of hospitalization due to sub-optimal medication use. Implementation: Previously validated indicators for MR-PPH were applied to patients with multimorbidity, aged 65 years or older and who were enrolled in a national community-based CDMP...
June 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917114/use-of-whole-genome-sequencing-of-adenovirus-in-immunocompromised-paediatric-patients-to-identify-nosocomial-transmission-and-mixed-genotype-infection
#16
Charlotte J Houldcroft, Sunando Roy, Sofia Morfopoulou, Ben K Margetts, Daniel P Depledge, Juliana Cudini, Divya Shah, Julianne R Brown, Erika Yara Romero, Rachel Williams, Elaine Cloutman-Green, Kanchan Rao, Joseph F Standing, John Hartley, Judith Breuer
Background: Adenoviruses are significant pathogens for the immunocompromised, arising from primary infection or reinfection. Serotyping is insufficient to support nosocomial transmission investigations. We investigate whether whole-genome sequencing (WGS) provides clinically relevant information on transmission among patients in a paediatric tertiary hospital. Methods: We developed a target-enriched adenovirus WGS technique for clinical samples and retrospectively sequenced 107 adenovirus-positive residual diagnostic samples, including viraemias (>5x104 copies/ml), from 37 patients collected January 2011 - March 2016...
June 4, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29917105/pancreatic-cancer-following-incident-diabetes-in-african-americans-and-latinos-the-multiethnic-cohort
#17
Veronica Wendy Setiawan, Daniel O Stram, Jacqueline Porcel, Suresh T Chari, Gertraud Maskarinec, Loïc Le Marchand, Lynne R Wilkens, Christopher A Haiman, Stephen J Pandol, Kristine R Monroe
Background: Diabetes has been proposed to be a risk factor for and a consequence of pancreatic cancer (PC). The relationship between recent-onset diabetes and PC is not well understood, and data in minorities are sparse. We examined the relationships between recent-onset diabetes and PC incidence in African Americans and Latinos in the Multiethnic Cohort. Methods: A total of 48 995 African Americans and Latinos without prior diabetes and cancer at baseline (1993-1996) were included in the study...
June 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29917086/frostbite-versus-burns-increased-cost-of-care-and-use-of-hospital-resources
#18
Rachel M Nygaard, Frederick W Endorf
Numerous demographic, socioeconomic, and injury factors influence a burn patient's hospital course. Compared to the typical burn patient, frostbite injury frequently impacts those with high rates of mental illness, substance abuse, and those suffering homelessness. Our aim was to examine differences in the hospital course of frostbite patients compared to those with burns limited to the hands and feet. Patients with frostbite injury and those with isolated hand and/or foot burns were identified in the National Burn Repository...
June 15, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29917083/sex-differences-in-reproductive-hormones-during-mini-puberty-in-infants-with-normal-and-disordered-sex-development
#19
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29917057/a-bayesian-space-time-model-for-clustering-areal-units-based-on-their-disease-trends
#20
Gary Napier, Duncan Lee, Chris Robertson, Andrew Lawson
Population-level disease risk across a set of non-overlapping areal units varies in space and time, and a large research literature has developed methodology for identifying clusters of areal units exhibiting elevated risks. However, almost no research has extended the clustering paradigm to identify groups of areal units exhibiting similar temporal disease trends. We present a novel Bayesian hierarchical mixture model for achieving this goal, with inference based on a Metropolis-coupled Markov chain Monte Carlo ((MC)$^3$) algorithm...
June 18, 2018: Biostatistics
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