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https://www.readbyqxmd.com/read/28655175/associations-of-acetylcholinesterase-inhibitor-treatment-with-reduced-mortality-in-alzheimer-s-disease-a-retrospective-survival-analysis
#1
Christoph Mueller, Gayan Perera, Richard D Hayes, Hitesh Shetty, Robert Stewart
Background: dementia is increasingly recognised as life-limiting condition. Although the benefits of acetylcholinesterase inhibitors (AChEIs) on cognition and function are well established, their effect on survival is less clear. Objective: to investigate associations between AChEI prescription and mortality in patients with Alzheimer's dementia (AD) in a naturalistic setting, using detailed baseline data on cognition, functioning, and mental and physical wellbeing...
June 24, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28654824/visceral-sensitivity-anxiety-and-smoking-among-treatment-seeking-smokers
#2
Michael J Zvolensky, Jafar Bakhshaie, Peter J Norton, Jasper A J Smits, Julia D Buckner, Lorra Garey, Kara Manning
It is widely recognized that smoking is related to abdominal pain and discomfort, as well as gastrointestinal disorders. Research has shown that visceral sensitivity, experiencing anxiety around gastrointestinal sensations, is associated with poorer gastrointestinal health and related health outcomes. Visceral sensitivity also increases anxiety symptoms and mediates the relation with other risk factors, including gastrointestinal distress. No work to date, however, has evaluated visceral sensitivity in the context of smoking despite the strong association between smoking and poor physical and mental health...
June 20, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28654822/gender-and-the-structure-of-self-rated-health-across-the-adult-life-span
#3
Anna Zajacova, Snehalata Huzurbazar, Megan Todd
Despite the widespread use of self-rated health (SRH) in population health studies, the meaning of this holistic health judgment remains an open question. Gender differences in health, an issue of utmost importance in population research and policy, are often measured with SRH; the comparisons could be biased if men and women differ in how they form their health judgment. The aim of this study is to examine whether men and women differ in how health inputs predict their health rating across the adult life span...
June 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28654682/low-intensity-cognitive-behaviour-therapy-interventions-for-obsessive-compulsive-disorder-compared-to-waiting-list-for-therapist-led-cognitive-behaviour-therapy-3-arm-randomised-controlled-trial-of-clinical-effectiveness
#4
Karina Lovell, Peter Bower, Judith Gellatly, Sarah Byford, Penny Bee, Dean McMillan, Catherine Arundel, Simon Gilbody, Lina Gega, Gillian Hardy, Shirley Reynolds, Michael Barkham, Patricia Mottram, Nicola Lidbetter, Rebecca Pedley, Jo Molle, Emily Peckham, Jasmin Knopp-Hoffer, Owen Price, Janice Connell, Margaret Heslin, Christopher Foley, Faye Plummer, Christopher Roberts
BACKGROUND: Obsessive-compulsive disorder (OCD) is prevalent and without adequate treatment usually follows a chronic course. "High-intensity" cognitive-behaviour therapy (CBT) from a specialist therapist is current "best practice." However, access is difficult because of limited numbers of therapists and because of the disabling effects of OCD symptoms. There is a potential role for "low-intensity" interventions as part of a stepped care model. Low-intensity interventions (written or web-based materials with limited therapist support) can be provided remotely, which has the potential to increase access...
June 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28654668/influence-of-the-way-of-reporting-alpha-amylase-values-in-saliva-in-different-naturalistic-situations-a-pilot-study
#5
María Dolores Contreras-Aguilar, Damián Escribano, Silvia Martínez-Subiela, Silvia Martínez-Miró, Mónica Rubio, Asta Tvarijonaviciute, Fernando Tecles, Jose J Cerón
The objective of this pilot study was to compare the different ways of measuring salivary alpha-amylase (sAA, enzymatic vs. concentration) and to evaluate the influence that the different ways of reporting the results can have in sAA interpretation. For this purpose, sAA was measured by direct quantification and also by an enzymatic assay in three different naturalistic situations, a physical stressor (situation 1) and two mental stressors of different intensity (situations 2 and 3). The results were expressed in three different ways (without correction, multiplied by flow rate and divided by protein concentration)...
2017: PloS One
https://www.readbyqxmd.com/read/28654570/fear-and-risk-of-falling-activities-of-daily-living-and-quality-of-life-assessment-when-older-adults-receive-emergency-department-care
#6
Tuğba Çinarli, Zeliha Koç
BACKGROUND: Falls tend to create fear and concern in older adults who also seek care in emergency departments (EDs) at high rates. AIM: The purposes of this study were to (a) describe risk and fear of falling in older adults seeking care in the ED and (b) explore relationships between risk and fear of falling with activities of daily living and quality of life. METHODS: The study was conducted in the ED of Ondokuz Mayis University Hospital in Samsun, Turkey...
July 2017: Nursing Research
https://www.readbyqxmd.com/read/28654551/assuring-sustainable-gains-in-interdisciplinary-performance-improvement-creating-a-shared-mental-model-during-operating-room-to-cardiac-icu-handoff
#7
Christine M Riley, Amber D Merritt, Justine M Mize, Jennifer J Schuette, John T Berger
OBJECTIVE: To understand sustainability and assure long-term gains in multidisciplinary performance improvement using an operating room to cardiac ICU handoff process focused on creation of a shared mental model. DESIGN: Performance improvement cohort project with pre- and postintervention assessments spanning a 4-year period. SETTING: Twenty-six bed pediatric cardiac ICU in a tertiary care children's hospital. PATIENTS: Cardiac surgery patients admitted to cardiac ICU from the operating room following cardiac surgery...
June 24, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28654549/workload-of-team-leaders-and-team-members-during-a-simulated-sepsis-scenario
#8
Nancy M Tofil, Yiqun Lin, John Zhong, Dawn Taylor Peterson, Marjorie Lee White, Vincent Grant, David J Grant, Ronald Gottesman, Stephanie N Sudikoff, Mark Adler, Kimberly Marohn, Jennifer Davidson, Adam Cheng
OBJECTIVES: Crisis resource management principles dictate appropriate distribution of mental and/or physical workload so as not to overwhelm any one team member. Workload during pediatric emergencies is not well studied. The National Aeronautics and Space Administration-Task Load Index is a multidimensional tool designed to assess workload validated in multiple settings. Low workload is defined as less than 40, moderate 40-60, and greater than 60 signify high workloads. Our hypothesis is that workload among both team leaders and team members is moderate to high during a simulated pediatric sepsis scenario and that team leaders would have a higher workload than team members...
June 24, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28654411/a-multi-method-investigation-of-pragmatic-development-in-individuals-with-down-syndrome
#9
Michelle Lee, Lauren Bush, Gary E Martin, Jamie Barstein, Nell Maltman, Jessica Klusek, Molly Losh
This longitudinal study examined pragmatic language in boys and girls with Down syndrome (DS) at up to three time points, using parent report, standardized and direct assessments. We also explored relationships among theory of mind, executive function, nonverbal mental age, receptive and expressive vocabulary, grammatical complexity, and pragmatic competence. Controlling for cognitive and language abilities, children with DS demonstrated greater difficulty than younger typically developing controls on parent report and standardized assessments, but only girls with DS differed on direct assessments...
July 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28654189/the-hospital-anxiety-and-depression-scale-hads-and-the-9-item-patient-health-questionnaire-phq-9-as-screening-instruments-for-depression-in-patients-with-cancer
#10
Tim J Hartung, Michael Friedrich, Christoffer Johansen, Hans-Ulrich Wittchen, Herman Faller, Uwe Koch, Elmar Brähler, Martin Härter, Monika Keller, Holger Schulz, Karl Wegscheider, Joachim Weis, Anja Mehnert
BACKGROUND: Depression screening in patients with cancer is recommended by major clinical guidelines, although the evidence on individual screening tools is limited for this population. Here, the authors assess and compare the diagnostic accuracy of 2 established screening instruments: the depression modules of the 9-item Patient Health Questionnaire (PHQ-9) and the Hospital Anxiety and Depression Scale (HADS-D), in a representative sample of patients with cancer. METHODS: This multicenter study was conducted with a proportional, stratified, random sample of 2141 patients with cancer across all major tumor sites and treatment settings...
June 27, 2017: Cancer
https://www.readbyqxmd.com/read/28654115/evidence-for-widespread-severe-brain-copper-deficiency-in-alzheimer-s-dementia
#11
Jingshu Xu, Stephanie J Church, Stefano Patassini, Paul Begley, Henry J Waldvogel, Maurice A Curtis, Richard L M Faull, Richard D Unwin, Garth J S Cooper
Datasets comprising simultaneous measurements of many essential metals in Alzheimer's disease (AD) brain are sparse, and available studies are not entirely in agreement. To further elucidate this matter, we employed inductively-coupled-plasma mass spectrometry to measure post-mortem levels of 8 essential metals and selenium, in 7 brain regions from 9 cases with AD (neuropathological severity Braak IV-VI), and 13 controls who had normal ante-mortem mental function and no evidence of brain disease. Of the regions studied, three undergo severe neuronal damage in AD (hippocampus, entorhinal cortex and middle-temporal gyrus); three are less-severely affected (sensory cortex, motor cortex and cingulate gyrus); and one (cerebellum) is relatively spared...
June 27, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28654010/effects-of-pup-separation-on-stress-response-in-postpartum-female-rats
#12
Manu Kalyani, Phyllis Callahan, James M Janik, Haifei Shi
There is a complex collection of neuroendocrine function during the postpartum period. Prolactin (PRL) released by suckling stimulus and its PRL receptors (PRL-R) in the central nervous system (CNS) are involved in hyporesponsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in lactating mammals including rodents and humans. It is not clear how long it takes to reestablish the attenuated HPA axis activity of lactating rats to a pre-pregnancy state after pup separation. We first tested the hypothesis that HPA axis activity in response to an acute stress in postpartum rats would return to a pre-pregnancy state after pup separation...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28653967/exercise-associated-hyponatremia-in-a-lactating-female
#13
Zach Bailowitz, Raymond Grams, David Teeple, Tamara Hew-Butler
A 37-year-old woman presented to the emergency department with severe headache, which quickly progressed to altered mental status and seizure activity in hospital. Her initial serum sodium concentration ([Na]) was 126 mmol/L. In the 24 hours before admission, she exercised vigorously for 120 minutes (interval training plus yoga) and also consumed more than 4 liters of fluid during that time to both stay hydrated and facilitate milk production because she was actively nursing 2 children. Her serum [Na] and altered mental status corrected slowly over the next 48 hours with furosemide, hypertonic saline, and fluid restriction...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653800/french-validation-of-the-maslach-burnout-inventory-student-survey-mbi-ss
#14
Christine Faye-Dumanget, Julie Carré, Margaux Le Borgne, Pr Abdel Halim Boudoukha
INTRODUCTION: Several international studies have been conducted on student burnout. To contribute to the clinical examination as well as research on the mental health of students, the MBI-SS (Maslach Burnout Inventory-Student Survey) has been validated and used in different countries but not in French. OBJECTIVE: The aim of this study is to examine the validity of the 3-dimensional model of the French version of the MBI-SS, which is characterized by emotional "Emotional Exhaustion" (EE); "Cynicism" (CY); and low scores in "Academic Efficacy" (AE)...
June 27, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28653672/the-impact-of-spinal-cord-injury-on-the-quality-of-life-of-primary-family-caregivers-a-literature-review
#15
REVIEW
J Lynch, R Cahalan
STUDY DESIGN: Literature review. OBJECTIVES: To provide a detailed review of the literature regarding the impact of spinal cord injury (SCI) on the quality of life (QOL) of family members who have become the primary caregiver and to highlight potential interventions available. METHODS: Appropriate databases were searched for relevant peer-reviewed studies. Twenty-five studies (four qualitative and 21 quantitative) were identified which investigated the role that family members play in caring for people with SCI and the impact it has on their QOL...
June 27, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28653646/early-predictors-of-outcome-after-mild-traumatic-brain-injury-upfront-an-observational-cohort-study
#16
Joukje van der Naalt, Marieke E Timmerman, Myrthe E de Koning, Harm J van der Horn, Myrthe E Scheenen, Bram Jacobs, Gerard Hageman, Tansel Yilmaz, Gerwin Roks, Jacoba M Spikman
BACKGROUND: Mild traumatic brain injury (mTBI) accounts for most cases of TBI, and many patients show incomplete long-term functional recovery. We aimed to create a prognostic model for functional outcome by combining demographics, injury severity, and psychological factors to identify patients at risk for incomplete recovery at 6 months. In particular, we investigated additional indicators of emotional distress and coping style at 2 weeks above early predictors measured at the emergency department...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28653614/conservative-management-and-health-related-quality-of-life-in-end-stage-renal-disease-a%C3%A2-systematic%C3%A2-review
#17
Hung-Bin Tsai, Chia-Ter Chao, Ray-E Chang, Kuan-Yu Hung, Cogent Study Group
PURPOSE: Few studies have addressed health-related quality of life (QoL) in patients who chose conservative management over dialysis. This systematic review aims to better define the role of conservative management in improving health-related QoL in patients with end-stage renal disease (ESRD). METHODS: Medline, Cochrane and EMBASE were searched for prospective or retrospective studies published until June 30, 2016, that examined QoL of ESRD patients. The primary outcome was health-related QoL...
June 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28653595/cohort-differences-in-exercise-adherence-among-primary-care-patients-referred-for-mental-health-versus-physical-health-conditions
#18
Patrick Tobi, Philip Kemp, Elena Schmidt
Aim To compare the characteristics of mental health and physical health participants attending an exercise referral scheme (ERS) and investigate associations with their adherence to exercise. BACKGROUND: While people referred to an ERS with a mental health diagnosis have similar initial rates of uptake as physical health participants, they are more likely to drop out. Comparisons of the groups to understand their differences and how these might impact on their adherence have been limited by the typically low numbers of mental health referrals in many schemes...
June 27, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28653549/sociodemographic-and-clinical-profiles-of-homeless-mentally-ill-admitted-in-mental-health-institute-of-south-india-know-the-unknown-project
#19
Guru S Gowda, G Gopika, Narayana Manjunatha, Channaveerachari Naveen Kumar, Ravi Yadav, Dwarakanath Srinivas, Bharath Rose Dawn, Suresh Bada Math
OBJECTIVES: A significant number of homeless mentally ill (HMI) patients without any personal, family or other identification details represent a unique problem in the psychiatric services of developing countries like India in the context of legal, humanitarian and treatment issues. These patients pose challenge to the mental health professional in diagnosis and management. AIMS: To study the sociodemographic and clinical profiles of HMI patients admitted under psychiatry...
June 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28653545/family-inclusion-in-mental-health-services-reality-or-rhetoric
#20
Robyn M Martin, Sophie C Ridley, Sue J Gillieatt
BACKGROUND: Contemporary mental health policies require family inclusion in the design, implementation and evaluation of services. MATERIALS: This scoping review considers the factors in mental health practice which either mediate or promote family inclusion. A wide range of factors are reported to obstruct family inclusion, while a smaller number of studies report that meaningful family inclusion rests on a partnership approach which values the input of families and services users...
June 1, 2017: International Journal of Social Psychiatry
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