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https://www.readbyqxmd.com/read/29652186/surgical-treatment-of-mild-to-severe-hallux-valgus-deformities-with-a-percutaneous-subcapital-osteotomy-combined-with-a-lateral-soft-tissue-procedure
#1
Mauro Maniglio, Paolo Fornaciari, Henrik Bäcker, Emanuel Gautier, Marc Lottenbach
Distal metatarsal (MT) osteotomies have been used in mild or moderate cases of hallux valgus (HV) and proximal MT osteotomy has been considered the treatment of choice for severe deformities. A distal osteotomy could achieve a greater degree of correction by the addition of a distal soft-tissue procedure and be used to treat also severe deformity. Limited evidence about the use of the percutaneous subcapital osteotomy (SCOT); a type of MT osteotomy, in combination of a soft tissue procedure, is available. We evaluated this procedure routinely used in our clinic...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29650033/enterovirus-serotypes-in-patients-with-central-nervous-system-and-respiratory-infections-in-viet-nam-1997-2010
#2
Nguyen Thi Thuy Chinh B'Krong, Ngo Ngoc Quang Minh, Phan Tu Qui, Tran Thi Hong Chau, Ho Dang Trung Nghia, Lien Anh Ha Do, Nguyen Ngoc Nhung, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan, H Rogier van Doorn, Tran Tan Thanh
BACKGROUND: Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), and are of interest as emerging viruses. Here, we typed Enterovirus A-D (EV) from central nervous system (CNS) and respiratory infections in Viet Nam. METHODS: Data and specimens from prospective observational clinical studies conducted between 1997 and 2010 were used...
April 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29649707/specific-smartphone-usage-and-cognitive-performance-affect-gait-characteristics-during-free-living-and-treadmill-walking
#3
Daniel Niederer, Anke Bumann, Yvonne Mühlhauser, Mareike Schmitt, Katja Wess, Tobias Engeroff, Jan Wilke, Lutz Vogt, Winfried Banzer
BACKGROUND: Mobile phone tasks like texting, typing, and dialling during walking are known to impact gait characteristics. Beyond that, the effects of performing smartphone-typical actions like researching and taking self-portraits (selfie) on gait have not been investigated yet. RESEARCH QUESTION: We aimed to investigate the effects of smartphone usage on relevant gait characteristics and to reveal potential association of basic cognitive and walking plus smartphone dual-task abilities...
April 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29644085/protein-molecular-modeling-shows-residue-t599-is-critical-to-wild-type-function-of-polg-and-description-of-a-novel-variant-associated-with-the-sando-phenotype
#4
John E Richter, Hector G Robles, Elizabeth Mauricio, Ahmed Mohammad, Paldeep S Atwal, Thomas R Caulfield
Sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) is a rare phenotype resulting from pathogenic variants of mitochondrial DNA polymerase gamma ( POLG ). We modeled a novel POLG variant, T599P, that causes the SANDO phenotype and another variant at the same residue, p.T599E, to observe their effect on protein function and confirm the pathogenicity of T599P. Through neoteric molecular modeling techniques, we show that changes at the T599 residue position introduce extra rigidity into the surrounding helix-loop-helix, which places steric pressure on nearby nucleotides...
2018: Human Genome Variation
https://www.readbyqxmd.com/read/29629578/dorsal-bridge-plating-or-transarticular-screws-for-lisfranc-fracture-dislocations
#5
N Kirzner, P Zotov, D Goldbloom, H Curry, H Bedi
Aims The aim of this retrospective study was to compare the functional and radiological outcomes of bridge plating, screw fixation, and a combination of both methods for the treatment of Lisfranc fracture dislocations. Patients and Methods A total of 108 patients were treated for a Lisfranc fracture dislocation over a period of nine years. Of these, 38 underwent transarticular screw fixation, 45 dorsal bridge plating, and 25 a combination technique. Injuries were assessed preoperatively according to the Myerson classification system...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29628697/seasonal-variation-in-orthopedic-trauma-patients-an-experience-from-central-india
#6
Rajeev Shukla, Nikhil Jain, Utkarsh Agarwal, Tanveer Sheikh, Ravikant Jain
Objectives: This study aims to determine the various epidemiological factors responsible for orthopedic trauma cases: how do weather patterns, month, season and public working schedule influence the daily frequency of orthopedic trauma. Material and methods: This was a descriptive study performed in the Department of Orthopedics at a tertiary care centre in central India Participants: 7980 trauma cases reported in our study period. Study variables: Demographic characteristics of the cases, time, day, the month of injury and type of trauma and cause of trauma...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29623811/assessment-of-the-compressive-and-tensile-mechanical-properties-of-materials-used-in-the-jaipur-foot-prosthesis
#7
Rachel H Teater, Kristine M Fischenich, Benjamin B Wheatley, Lisa Abrams, Sheryl A Sorby, Harlal Singh Mali, Anil Jain, Tammy L Haut Donahue
BACKGROUND: Designed by Dr. Sethi, the Jaipur Foot prosthesis is ideally suited for amputees in developing countries as it utilizes locally sourced, biodegradable, inexpensive materials and is focused on affordability and functionality. To date, however, no data have been reported on the material properties of the foot components. OBJECTIVES: The goal of this work was to evaluate mechanical properties of the Jaipur Foot components to guide foot design and manufacturing and reduce weight...
April 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29623809/participation-in-active-play-of-children-who-use-lower-extremity-prostheses-an-exploratory-questionnaire
#8
Cheryl Kerfeld, Tracy Jirikowic, Katheryn J Allyn, Murray E Maitland
BACKGROUND: Through play, children develop motor, cognitive, social, and other life skills. Play barriers can impede physical and psychosocial benefits. OBJECTIVES: We describe participation in active play, fundamental movement skills, play environment characteristics, and potential play barriers for school-aged children (6-12 years) who use lower extremity prostheses. STUDY DESIGN: Cross-sectional questionnaire study. METHODS: A questionnaire was developed and administered online to parents of children 6-12 years who use lower extremity prostheses...
April 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29621736/antiviral-activity-of-porcine-interferon-delta-8-against-foot-and-mouth-disease-virus-in-vitro
#9
Shi-Fang Li, Jun-Jun Shao, Fu-Rong Zhao, Mei-Jiao Gong, Yin-Li Xie, Hui-Yun Chang, Yong-Guang Zhang
Foot-and-mouth disease (FMD) is one of the most devastating diseases affecting livestock. Since vaccines fail to provide protection until seven days post-vaccination, the application of anti-viral molecules is imperative for suppressing the spread of FMDV prior to development of an adaptive immune response. Interferons (IFNs) are effective for the host to fight FMDV infections; however, a novel type I IFNs, interferon delta (IFN-δ), has not been investigated for their antiviral effects against this virus. Thus, this study investigated FMDV infection, upon pre- and post-treatment with PoIFN-δ8...
April 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29619845/contribution-of-medial-cuneiform-osteotomy-to-correction-of-longitudinal-arch-collapse-in-stage-iib-adult-acquired-flatfoot-deformity
#10
Grace C Kunas, Huong T Do, Amiethab Aiyer, Jonathan T Deland, Scott J Ellis
Background Residual forefoot supination after correcting the hindfoot in stage IIb adult-acquired flatfoot deformity can be addressed with a dorsal opening wedge medial cuneiform (Cotton) osteotomy. The amount of correction is generally judged clinically, and there currently are no preoperative guides that can predict the size of graft needed. The aim of this study was to evaluate the correlation between patient and operative factors and the correction achieved with the Cotton osteotomy. METHODS: Seventy-nine feet in 74 patients undergoing Cotton osteotomy as part of flatfoot reconstruction were reviewed retrospectively...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29617149/effect-of-surgical-weight-loss-on-plantar-fasciitis-and-healthcare-utilization
#11
Mena Boules, Esam Batayyah, Dvir Froylich, Andrea Zelisko, Colin O'Rourke, Stacy Brethauer, Kevin El-Hayek, Allan Boike, Andrew Strong, Matthew Kroh
BACKGROUND: Plantar fasciitis (PF) is known to be one of the most common causes of heel pain. Obesity is recognized as a significant factor in PF development, possibly due to increased mechanical loading of the foot as a result of excess weight. The benefit of bariatric surgery is documented for other comorbidities but not for PF. METHODS: Retrospective chart review of patients with a diagnosis of PF identified from a prospectively maintained database of the Cleveland Clinic Bariatric and Metabolic Institute...
April 4, 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29616845/lateralizing-calcaneal-osteotomies-and-their-effect-on-calcaneal-alignment-a-three-dimensional-digital-model-analysis
#12
Elizabeth A Cody, Andrew P Kraszewski, Matthew S Conti, Scott J Ellis
BACKGROUND: Few authors have directly compared multiple types of lateralizing calcaneal osteotomies (LCOs) in terms of their ability to achieve deformity correction. The aim of this research was to use a digital model of a varus hindfoot to compare 4 different LCOs in terms of deformity correction and amount of tuberosity lateralization required. The authors hypothesis was that osteotomies involving a wedge resection would achieve greater correction with less lateralization. METHODS: A weightbearing computed tomographic scan of a patient with a varus hindfoot deformity was used to construct a 3-dimensional digital model of the hindfoot, preserving weightbearing alignment...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29616085/assessment-of-telomerase-activity-in-leukocytes-of-type-2-diabetes-mellitus-patients-having-or-not-foot-ulcer-possible-correlation-with-other-clinical-parameters
#13
Dimitrios Baltzis, Evangelia Meimeti, Maria G Grammatikopoulou, Matthieu Roustit, Eleni Mavrogonatou, Dimitris Kletsas, Smaragda Efraimidou, Christos Manes, Taxiarchis K Nikolouzakis, John Tsiaoussis, Aristides M Tsatsakis, Demetrios A Spandidos, Christina-Maria Trakatelli, Nikolaos Drakoulis
Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: Νon-ulcer group (N=58) and ulcer group (N=32)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29614570/-clinical-features-and-genetic-variants-of-dent-disease-in-10-children
#14
S L Zhao, F Zhao, Y G Sha, Q X Chen, X Q Cheng, S M Huang
Objective: To summarize the clinical features and genetic analysis results of 10 children with Dent disease. Methods: The clinical data and gene test results of 10 boys aged from 8 months to 12 years with Dent disease diagnosed in Children's Hospital of Nanjing Medical University from January 2014 to July 2017 were analyzed retrospectively. Results: All patients had insidious onset, 5 cases were found to have proteinuria on routine urine examination after hospitalization duo to other diseases, 4 cases were admitted to hospital because increased foams in the urine, and 1 case was found to have proteinuria on health checkup...
April 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29611840/quality-of-care-for-patients-with-diabetes-done-by-family-medicine-team-during-the-period-2013-2016
#15
Larisa Gavran, Salih Tandir, Suad Sivić, Fatima Topčić
Aim To assess whether the quality of diabetes care provided by a family medicine team changed over the course of four years and to identify potential gaps in our practice in order to improve it in the future. Methods An audit was carried out for randomly selected 120 medical records (MC) from the Diabetes Registry of patients with type 1 or 2 diabetes mellitus treated by one family medicine team for four consecutive years, from 2013 to 2016. We examined demographic data (gender, age, diabetes type, family history), annual examinations (glycated haemoglobin, blood glucose, lipid profile, neurological examination, urinalysis, foot care, ocular fundus and body mass index), prescribed insulin or other drugs and patients' education...
August 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29609253/-study-on-early-warning-threshold-values-for-7-common-communicable-diseases-in-gansu-province-2016
#16
Y Cheng, X F Liu, L Meng, X T Yang, D P Liu, K F Wei, X J Jiang, H X Liu, Y H Zheng
Objective: To optimize the warning threshold values of common communicable diseases in Gansu province, and improve the early warning effect. Method: An early warning model was set up for influenza, scarlet fever, other infectious diarrheal diseases, dysentery, typhoid and paratyphoid, viral hepatitis type E and hand foot and mouth disease (HFMD) respectively in Gansu by using the moving percentile method and cumulative sum method. By calculating the sensitivity, specificity, predictive value of positive test, predictive value of negative test, Youden' index and receiver-operating characteristic curve, the optimum early warning threshold values for communicable diseases in Gansu were selected...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29607820/assessment-of-sunitinib-alternative-prescription-schedules-in-metastatic-kidney-cancer-a-study-of-10-cases
#17
Habib Diallo, Hasnae Alaoui Mhamdi, Salma Elouarzazi, Mohamed Fadli, Rhizlane Belbaraka
BACKGROUND: Managing metastatic Renal Cell Carcinoma (mRCC) has been revolutionized during the first decade of the 21st century due to the development of targeted therapies. The sunitinib is an oral multi-targeted receptor Tyrosine Kinase Inhibitor (TKI). It became the first targeted therapy as first-line treatment to improve the survival of patients with metastatic kidney cancer. This treatment consists in the oral intake of 50 mg of sunitinib per day in a 6 -week cycle including 4 weeks of treatment intake (the "on" week) followed by a 2-week break (the off week)...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29604389/effects-of-sodium-glucose-cotransporter-2-inhibitors-on-cardiovascular-disease-death-and-safety-outcomes-in-type-2-diabetes-a-systematic-review
#18
REVIEW
Karin Rådholm, Jason Hy Wu, Muh Geot Wong, Celine Foote, Gregory Fulcher, Kenneth W Mahaffey, Vlado Perkovic, Bruce Neal
AIM: Sodium glucose co-transporter 2 (SGLT2) inhibitors appear to protect against increased risks of cardiovascular and kidney disease in patients with type 2 diabetes but also cause some harms. Whether effects are comparable across drug class or specific to individual compounds is unclear. This meta-analysis assessed the class and individual compound effects of SGLT2 inhibition versus control on cardiovascular events, death, kidney disease and safety outcomes in patients with type 2 diabetes...
March 28, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29603282/sequence-analysis-based-characterization-and-identification-of-neurovirulence-associated-variants-of-36-ev71-strains-from-china
#19
Jun Xu, Fang Wang, Desheng Zhao, Jiang Liu, Hong Su, Baolong Wang
Enterovirus 71 (EV71) is the main pathogen of hand-foot-mouth disease (HFMD) and causes several neurological complications. As new strains of EV71 are constantly discovered, it is important to understand the genomic characteristics of the viruses and the mechanism of virulence. Herein, we isolated five strains of EV71 from HFMD patients with or without neurovirulence and sequenced their whole genomes. We then performed whole genome sequence analysis of totally 36 EV71 strains. The phylogenetic analysis of the VP1 region revealed all five isolated strains are clustered into C4a of C4 subgenotype...
March 30, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29596945/association-between-diabetic-peripheral-neuropathy-and-heart-rate-variability-in-subjects-with-type-2-diabetes
#20
S K M Azizul Islam, Dongkyu Kim, Young-Sil Lee, Seong-Su Moon
AIM: This study evaluated the association of Heart rate variability (HRV) measurements with diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes. METHODS: This study included 102 Korean subjects with type 2 diabetes. The Michigan neuropathy screening instrument (MNSI) questionnaire score, the MNSI examination score (MNSIES) and the total symptom score were examined for DPN evaluation. Noninvasive HRV measurements were performed using photoelectric plethysmography...
March 26, 2018: Diabetes Research and Clinical Practice
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