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https://www.readbyqxmd.com/read/29035584/hybrid-fixation-for-ankle-fusion-in-diabetic-charcot-arthropathy
#1
Hani El-Mowafi, Mazen Abulsaad, Yasser Kandil, Ahmed El-Hawary, Samer Ali
BACKGROUND: Ankle fusion is difficult to achieve in the diabetic Charcot ankle Brodsky type 3a because of the poor quality of the bone and the inability to achieve a stable biomechanical construct. The aim of this study was to report the outcome of ankle fusion using a combination of an intramedullary nail and a circular external fixator in patients with diabetic Charcot arthropathy. METHODS: We prospectively studied 24 patients with diabetic Charcot arthropathy of the ankle who were treated by fusion of the tibiotalar joint using a combined retrograde intramedullary nail and Ilizarov external fixator...
October 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29033898/functional-characterization-of-paralogous-gonadotropin-releasing-hormone-type-and-corazonin-type-neuropeptides-in-an-echinoderm
#2
Shi Tian, Michaela Egertová, Maurice R Elphick
Homologs of the vertebrate neuropeptide gonadotropin-releasing hormone (GnRH) have been identified in invertebrates, including the insect neuropeptide corazonin (CRZ). Recently, we reported the discovery of GnRH-type and CRZ-type signaling systems in an echinoderm, the starfish Asterias rubens, demonstrating that the evolutionary origin of paralogous GnRH-type and CRZ-type neuropeptides can be traced back to the common ancestor of protostomes and deuterostomes. Here, we have investigated the physiological roles of the GnRH-type (ArGnRH) and the CRZ-type (ArCRZ) neuropeptides in A...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29032641/cholic-acid-attenuate-er-stress-induced-cell-death-in-coxsackievirus-b3-infection
#3
Jae-Young Han, Hae In Jeong, Cheol-Woo Park, Jisoo Yoon, Jaeyoung Ko, Sang-Jip Nam, Byung-Kwan Lim
Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes of various diseases such as myocarditis and hand-foot-mouth diseases. But effective antiviral drug was still not developed. In this study, we looking for potential inhibitors of CVB3 replication by examining survival of CVB3-infected HeLa cells. We detected an antiviral effect of cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps digestion and absorption of lipids in small intestine...
October 14, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29029862/hidden-dangers-revealed-by-misdiagnosed-diabetic-neuropathy-a-comparison-of-simple-clinical-tests-for-the-screening-of-vibration-perception-threshold-at-primary-care-level
#4
Kurt Azzopardi, Alfred Gatt, Nachiappan Chockalingam, Cynthia Formosa
AIM: Diabetic peripheral neuropathy is an important complication and contributes to the morbidity of diabetes mellitus. Evidence indicates early detection of diabetic peripheral neuropathy results in fewer foot ulcers and amputations. The aim of this study was to compare different screening modalities in the detection of diabetic peripheral neuropathy in a primary care setting. METHOD: A prospective non-experimental comparative multi-centre cross sectional study was conducted in various Primary Health Centres...
October 10, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/29029508/efficiency-of-low-dosage-apatinib-in-post-first-line-treatment-of-advanced-lung-adenocarcinoma
#5
Da-Xiong Zeng, Chang-Guo Wang, Wei Lei, Jian-An Huang, Jun-Hong Jiang
Chemotherapy is the standard treatment of in advanced lung adenocarcinoma patients without driver mutation. However, few drugs could be selected when diseases progressed after second-line treatment. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), apatinib was suggested mainly using in advanced gastric cancer. In this study, we showed the results of apatinib as second-line to fourth-line treatment in EGFR wild-type advanced lung adenocarcinoma patients. 16 EGFR wild-type advanced lung adenocarcinoma patients were administrated apatinib (250-500 mg/d) orally...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29023846/locomotor-and-skeletal-muscle-abnormalities-in-trembler-j-neuropathic-mice
#6
Darin J Falk, Tori Galatas, Adrian G Todd, Elliott P Soto, Andrew B Harris, Lucia Notterpek
INTRODUCTION: Patients with hereditary peripheral neuropathies exhibit characteristic deformities of the hands and feet and have difficulty ambulating. To examine to what extent neuropathic animals recapitulate these deficits, we studied Trembler J mice, which model early-onset demyelinating neuropathy. METHODS: A cohort of 4-month old female wild type and neuropathic mice were evaluated for locomotor measurements, neuromuscular function and skeletal muscle proteolysis and morphometry...
October 12, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29023503/model-uncertainties-do-not-affect-observed-patterns-of-species-richness-in-the-amazon
#7
Lilian Patrícia Sales, Olívia Viana Neves, Paulo De Marco, Rafael Loyola
BACKGROUND: Climate change is arguably a major threat to biodiversity conservation and there are several methods to assess its impacts on species potential distribution. Yet the extent to which different approaches on species distribution modeling affect species richness patterns at biogeographical scale is however unaddressed in literature. In this paper, we verified if the expected responses to climate change in biogeographical scale-patterns of species richness and species vulnerability to climate change-are affected by the inputs used to model and project species distribution...
2017: PloS One
https://www.readbyqxmd.com/read/29021983/an-integrated-framework-for-process-driven-model-construction-in-disease-ecology-and-animal-health
#8
REVIEW
Rebecca Mancy, Patrick M Brock, Rowland R Kao
Process models that focus on explicitly representing biological mechanisms are increasingly important in disease ecology and animal health research. However, the large number of process modelling approaches makes it difficult to decide which is most appropriate for a given disease system and research question. Here, we discuss different motivations for using process models and present an integrated conceptual analysis that can be used to guide the construction of infectious disease process models and comparisons between them...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29020959/configurable-wearable-sensing-and-vibrotactile-feedback-system-for-real-time-postural-balance-and-gait-training-proof-of-concept
#9
Junkai Xu, Tian Bao, Ung Hee Lee, Catherine Kinnaird, Wendy Carender, Yangjian Huang, Kathleen H Sienko, Peter B Shull
BACKGROUND: Postural balance and gait training is important for treating persons with functional impairments, however current systems are generally not portable and are unable to train different types of movements. METHODS: This paper describes a proof-of-concept design of a configurable, wearable sensing and feedback system for real-time postural balance and gait training targeted for home-based treatments and other portable usage. Sensing and vibrotactile feedback are performed via eight distributed, wireless nodes or "Dots" (size: 22...
October 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29019756/imaging-of-skeletal-disorders-caused-by-fibroblast-growth-factor-receptor-gene-mutations
#10
Kiran M Sargar, Achint K Singh, Simon C Kao
Fibroblast growth factors and fibroblast growth factor receptors (FGFRs) play important roles in human axial and craniofacial skeletal development. FGFR1, FGFR2, and FGFR3 are crucial for both chondrogenesis and osteogenesis. Mutations in the genes encoding FGFRs, types 1-3, are responsible for various skeletal dysplasias and craniosynostosis syndromes. Many of these disorders are relatively common in the pediatric population, and diagnosis is often challenging. These skeletal disorders can be classified based on which FGFR is affected...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28994758/using-gold-standard-gait-analysis-methods-to-assess-experience-effects-on-lower-limb-mechanics-during-moderate-high-heeled-jogging-and-running
#11
Yan Zhang, Meizi Wang, Jan Awrejcewicz, Gusztáv Fekete, Feng Ren, Yaodong Gu
A limited number of studies have explored lower-limb biomechanics during high-heeled jogging and running, and most studies have failed to clarify the wearing experience of subjects. This protocol describes the differences in lower-limb kinematics and ground reaction force (GRF) between experienced wearers (EW) and inexperienced wearers (IEW) during moderate high-heeled jogging and running. A three-dimensional (3D) motion analysis system with a configured force platform was used to synchronously capture lower-limb joint movements and GRF...
September 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28993503/myh9-e1841k-mutation-augments-proteinuria-and-podocyte-injury-and-migration
#12
Sylvia Cechova, Fan Dong, Fang Chan, Michael J Kelley, Phillip Ruiz, Thu H Le
Intronic variants of the MYH9 gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle cell disease-associated nephropathy. However, the causal functional variants of MYH9 have remained elusive. Rare missense mutations in MYH9 cause macrothrombocytopenia and are occasionally associated with development of nephropathy. The E1841K mutation is among the common MYH9 missense mutations and has been associated with nephropathy in some carriers...
October 9, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28992095/the-reduction-of-heparan-sulphate-in-the-glomerular-basement-membrane-does-not-augment-urinary-albumin-excretion
#13
Satoshi Aoki, Akiko Saito-Hakoda, Takeo Yoshikawa, Kyoko Shimizu, Kiyomi Kisu, Susumu Suzuki, Kiyoshi Takagi, Shuji Mizumoto, Shuhei Yamada, Toin H van Kuppevelt, Atsushi Yokoyama, Taiji Matsusaka, Hiroshi Sato, Sadayoshi Ito, Akira Sugawara
Background: Heparan sulphate proteoglycan (HSPG) is present in the glomerular basement membrane (GBM) and is thought to play a major role in the glomerular charge barrier. Reductions and structural alterations of HSPG are observed in different types of kidney diseases accompanied by proteinuria. However, their causal relations remain unknown. Methods: We generated podocyte-specific exostosin-like 3 gene ( Extl3 ) knockout mice ( Extl3KO ) using a Cre-loxP recombination approach...
July 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28990512/fighting-type-2-diabetes-present-and-future-perspectives
#14
Cai-Guo Yu, Ying Fu, Yuan Fang, Ning Zhang, Rong-Xin Sun, Dong Zhao, Ying-Mei Feng, Bao-Yu Zhang
BACKGROUND: Type-2 diabetes mellitus accounts for 80-90% of diabetic patients. So far, the treatment of diabetes mainly aims at elevating insulin level and lowering glucose level in the peripheral blood and mitigating insulin resistance. Physiologically, insulin secretion from pancreatic β cells is delicately regulated. Thus, how insulin-related therapies could titrate blood glucose appropriately and avoid the occurrence of hypoglycemia remains an important issue for decades. Similar question is addressed on how to attenuate vascular complication in diabetic subjects...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28988268/epidemiology-of-dance-related-injuries-presenting-to-emergency-departments-in-the-united-states-2000-2013
#15
Amy J Vassallo, Claire Hiller, Emmanuel Stamatakis, Evangelos Pappas
Dance is a popular activity associated with many physical and mental health benefits, but injuries are a concern for all skill levels. Previous studies have focused on professional dancers or particular genres, meaning the population-wide characteristics of injuries is unknown. This study's objective was to identify the incidence and types of dance-related injuries evaluated in emergency departments in the United States over the 14-year period 2000-2013. METHODS: Data were obtained from the nationally representative National Electronic Injury Surveillance System from 2000-2013...
September 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28987971/best-seating-condition-in-children-with-spastic-cerebral-palsy-one-type-does-not-fit-all
#16
Mattana Angsupaisal, Linze-Jaap Dijkstra, Sacha la Bastide-van Gemert, Jessika F van Hoorn, Karine Burger, Carel G B Maathuis, Mijna Hadders-Algra
BACKGROUND: The effect of forward-tilting of the seat surface and foot-support in children with spastic cerebral palsy (CP) is debated. AIM: To assess the effect of forward-tilting of the seat surface and foot-support in children with CP on kinematic head stability and reaching. METHODS: Nineteen children functioning at Gross Motor Function Classification System levels I-III participated [range 6-12y; ten unilateral spastic CP (US-CP) and nine bilateral spastic CP (BS-CP)]...
October 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28985488/plantar-pressure-differences-between-cases-with-symptoms-of-clinically-diagnosed-chronic-exertional-compartment-syndrome-and-asymptomatic-controls
#17
Andrew Roberts, David Hulse, Alexander N Bennett, Sharon Dixon
BACKGROUND: Anterior chronic exertional compartment syndrome of the leg has been hypothesised to develop due to excessive muscle activity and foot pronation. Plantar pressure variables related to lower limb muscle activity and foot type may therefore provide insight into this condition. METHODS: 70 male cases and 70 asymptomatic controls participated. A clinical diagnosis was established from typical symptoms, with clinical examination excluding other pathologies...
October 2, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28983285/microbiota-of-chronic-diabetic-wounds-ecology-impact-and-potential-for-innovative-treatment-strategies
#18
REVIEW
Sónia G Pereira, João Moura, Eugénia Carvalho, Nuno Empadinhas
World Health Organization considered diabetes as one of the 20th century epidemics, estimating that over 10% of the world population is diabetic or at high risk. Self-assessment studies indicate that diabetic patients consider chronic wounds to affect their quality of life more dramatically than vision loss or renal failure. In addition to being the main reason for diabetic patients' hospitalization, the economic burden of diabetic chronic wounds is close to 1% of United Kingdom and United States health systems budgets, which exceeds the funds allocated to the treatment of some types of cancer in both countries...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28979615/-podiatric-risk-screening-in-patients-with-type-2-diabetes-in-antananarivo
#19
Sitraka Angelo Raharinavalona, Haritsiky Robertini Ramalanjaona, Nalisoa Andrianera, Andrinirina Dave Patrick Rakotomalala, George Ramahandridona
Diabetic foot disease heavily weighs upon diabetics, being a significant cause of morbidity and severe disability. Their prevention is indispensable. Our study aimed to reduce the rate of amputations in diabetics. We conducted a retrospective, descriptive, cross-sectional, multicenter study of podiatric risk screening in patients with type 2 diabetes in the Endocrinology Department at the University Hospital of Befelatanana and at the Amadia Clinic, Faravohitra, over a period of 6 months. The average age of our patients was 54...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28977768/interspecific-comparison-of-hantavirus-prevalence-in-peromyscus-populations-from-a-fragmented-agro-ecosystem-in-indiana
#20
Jacob L Berl, Amy J Kuenzi, Elizabeth A Flaherty, Robert K Swihart
Comparatively little is known about hantavirus prevalence within rodent populations from the Midwestern US, where two species of native mice, the prairie deer mouse (Peromyscus maniculatus bairdii) and the white-footed mouse (Peromyscus leucopus noveboracensis), are dominant members of rodent communities. We sampled both species in central Indiana and tested individuals for presence of hantavirus antibodies to determine whether seroprevalence (percent of individuals with antibodies reactive to Sin Nombre virus antigen) differed between species, or among different habitat types within fragmented agro-ecosystems...
October 4, 2017: Journal of Wildlife Diseases
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