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https://www.readbyqxmd.com/read/28634750/t135i-substitution-in-the-nonstructural-protein-2c-enhances-foot-and-mouth-disease-virus-replication
#1
Tiangang Yuan, Haiwei Wang, Chen Li, Decheng Yang, Guohui Zhou, Li Yu
The foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays an important role in viral replication, virulence, and host range. It has been shown that deletions of 10 or 19-20 amino acids in the C-terminal half of 3A attenuate serotype O and C FMDVs, which replicate poorly in bovine cells but normally in porcine-derived cells, and the C-terminal half of 3A is not essential for serotype Asia1 FMDV replication in BHK-21 cells. In this study, we constructed a 3A deletion FMDV mutant based on a serotype O FMDV, the wild-type virus O/YS/CHA/05, with a 60-amino acid deletion in the 3A protein sequence, between residues 84 and 143...
June 20, 2017: Virus Genes
https://www.readbyqxmd.com/read/28633784/complications-of-talar-neck-fractures-by-hawkins-classification-a%C3%A2-systematic-review
#2
REVIEW
Richard K Jordan, Kunaal R Bafna, Jiayong Liu, Nabil A Ebraheim
The goal of the present study was to perform a systematic review of the published data on talar neck fractures for a better understanding of the postoperative clinical outcomes using open reduction and internal fixation stratified by Hawkins type. A PubMed search was performed using the keywords "talar," "neck," and "fracture." This search identified 209 potential studies, which were reviewed to yield 16 studies that met the criteria. The surgical outcomes of talar neck fractures stratified by the Hawkins classification analyzed in the present study were as follows: American Orthopaedic Foot and Ankle Society scale score was 77...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633164/ann-prediction-of-ligament-stiffnesses-for-the-enhanced-predictive-ability-of-a-patient-specific-computational-foot-ankle-model
#3
Ruchi Chande, Jennifer S Wayne
Computational models of diarthrodial joints serve to inform the biomechanical function of these structures, and as such, must be supplied appropriate inputs for performance that is representative of actual joint function. Inputs for these models are sourced from both imaging modalities as well as literature. The latter is often the source of mechanical properties for soft tissues, like ligament stiffnesses; however, such data is not always available for all soft tissues nor is it known for patient specific work...
June 20, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28632746/body-part-compatibility-effects-are-modulated-by-the-tendency-for-women-to-experience-negative-social-comparative-emotions-and-the-body-type-of-the-model
#4
Eva Pila, Kimberely Jovanov, Timothy N Welsh, Catherine M Sabiston
Although exposure to physique-salient media images of women's bodies has been consistently linked with negative psychological consequences, little is known about the cognitive processes that lead to these negative effects. The present study employed a novel adaptation of a computerized response time (RT) task to (i) assess implicit cognitive processing when exposed to the body of another individual, and (ii) examine individual differences in social comparative emotions that may influence the cognitive processing of human bodies...
2017: PloS One
https://www.readbyqxmd.com/read/28631141/cell-labeling-with-magneto-endosymbionts-and-the-dissection-of-the-subcellular-location-fate-and-host-cell-interactions
#5
Kayla R Lee, Abdul Wakeel, Papia Chakraborty, Chandler S Foote, Lauren Kajiura, Joyce C Barrozo, Andrea C Chan, Alexey V Bazarov, Ryan Spitler, Peter M Kutny, Jim M Denegre, Rob A Taft, Joachim Seemann, Bradley W Rice, Christopher H Contag, Brian K Rutt, Caleb B Bell
PURPOSE: The purposes of this study are to characterize magneto-endosymbiont (ME) labeling of mammalian cells and to discern the subcellular fate of these living contrast agents. MEs are novel magnetic resonance imaging (MRI) contrast agents that are being used for cell tracking studies. Understanding the fate of MEs in host cells is valuable for designing in vivo cell tracking experiments. PROCEDURES: The ME's surface epitopes, contrast-producing paramagnetic magnetosomal iron, and genome were studied using immunocytochemistry (ICC), Fe and MRI contrast measurements, and quantitative polymerase chain reaction (qPCR), respectively...
June 19, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28630584/time-loss-injuries-in-sub-elite-and-emerging-rugby-league-players
#6
Mark Booth, Rhonda Orr
This study aimed to 1) investigate the incidence and characteristics of injuries in emerging rugby league players; and 2) explore the differences in injury incidence and characteristics between the various sub-elite competitions. An NRL emerging player development squad (n = 34) was observed from the beginning of pre-season until the finish of competition. Time-loss injury was defined as any physical pain or impairment sustained that resulted in players missing a match. Injuries were categorised according to circumstance, incidence, characteristics, playing position and competition level...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28628523/effectiveness-of-surgery-for-adults-with-hallux-valgus-deformity-a-systematic-review
#7
Jitka Klugarova, Victoria Hood, Fiona Bath-Hextall, Miloslav Klugar, Jana Mareckova, Zuzana Kelnarova
BACKGROUND: Hallux valgus (HV) is a common foot deformity. In severe stages of this condition, surgery is often necessary. Currently, there is no systematic review comparing the effectiveness of surgery over conservative treatment. OBJECTIVES: The objective of this review was to establish the effectiveness of surgery compared to conservatory management for adults with HV. INCLUSION CRITERIA TYPES OF PARTICIPANTS: The current review included adults (18 years or over) with HV deformity, excluding adults with neurological problems causing foot deformities, for example, cerebral palsy, neuropathy, stroke and multiple sclerosis...
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28627865/the-value-of-color-doppler-ultrasound-in-the-diagnosis-of-lower-extremity-vascular-disease-in-type-2-diabetes-and-an-analysis-of-related-factors
#8
Le Jiang, Yuehua Zhao
BACKGROUND: The aim of this paper is to explore the application and clinical significance of color Doppler ultrasound (CDU) in diagnosing lower extremity vascular disease in type 2 diabetes mellitus (T2DM) patients. METHODS: The lower extremity arteries of 81 patients with T2DM and 50 control patients were examined by CDU for blood vessel diameter, intima-media thickness, plaque on the vessel wall, lumen stenosis and filling defect in blood flow. The occurrence of diabetes mellitus was investigated in additional T2DM patients of various ages...
September 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28626746/frequency-of-cutaneous-fungal-infections-and-azole-resistance-of-the-isolates-in-patients-with-diabetes-mellitus
#9
Omid Raiesi, Mansour Siavash, Faezeh Mohammadi, Javaher Chabavizadeh, Behzad Mahaki, Mehrnoush Maherolnaghsh, Parvin Dehghan
BACKGROUND: Diabetic patients are more susceptible to cutaneous fungal infections. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. The main objective of this study was to find the frequency of fungal infections among cutaneous lesions of diabetic patients and to investigate azole antifungal agent susceptibility of the isolates. MATERIALS AND METHODS: In this study, type 1diabetes (n = 78) and type 2 diabetes (n = 44) comprised 47 cases (38...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28626324/lower-trunk-muscle-activity-induced-alignment-and-cop-position-during-single-leg-standing
#10
Tetsuya Nakao, Kenichi Masuda, Shigeyuki Kanai, Junzo Tsujita, Kazufumi Hirakawa, Shuichi Okada
[Purpose] The purpose of this study was to clarify fundamental changes induced by lower trunk muscle contraction during single-leg standing. [Subjects and Methods] Ten healthy normal males participated in this study. All subjects could accurately perform lower trunk muscle contraction-type Abdominal Expansion (AE), Abdominal Bracing (AB), and Abdominal Cave-in (AC). The alignment and position of the center of foot pressure (COP) during single-leg standing with SLR and step position after rotating the body from single-leg standing with maximum SLR were measured in each lower trunk muscle contraction type...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28623062/salvage-of-the-foot-for-recurrent-malignant-peripheral-nerve-sheath%C3%A2-tumor
#11
Meletis Rozis, Eustratios Papadelis, Andreas Mavrogenis, Spyridon Koufos, Vasilios Polyzois, Spyros Pneumaticos
Malignant peripheral nerve sheath tumors are rare soft tissue tumors accounting for 3% to 10% of all soft tissue tumors. They are strongly related to neurofibromatosis type 1, an autosomal dominant disease, and are characterized by aggressive biologic behavior, high local recurrence rates, and frequent metastases. Although the major nerves of the lower extremities are a common location of these tumors, scarce cases have been reported of malignant peripheral nerve sheath tumors involving the interdigital nerves of the foot...
June 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28619310/dance-for-parkinson-s-the-effects-on-whole-body-co-ordination-during-turning-around
#12
Sophia Hulbert, Ann Ashburn, Lisa Roberts, Geert Verheyden
OBJECTIVE: To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. DESIGN: This study employed a randomised, controlled, experimental design. SETTING: Dance classes were performed in a community dance centre in Southern England and all assessments took place a gait laboratory. PARTICIPANTS: Twenty-seven people with mild-moderate Parkinson's participated. INTERVENTION: Participants were randomly allocated to receive either 20, 1-h dancing classes over 10 weeks (n=15), or a 'usual care' control group (n=12)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28618043/nurses-knowledge-on-diabetic-foot-ulcer-disease-and-their-attitudes-towards-patients-affected-a-cross-sectional-institution-based-study
#13
Sriyani A Kumarasinghe, Priyadarshika Hettiarachchi, Sudharshani Wasalathanthri
AIMS AND OBJECTIVES: To assess nurses' knowledge on diabetic ulcer disease and their attitudes towards patients suffering from it and to identify factors which influence them. BACKGROUND: Diabetic wound care is an evolving specialty with the rising prevalence of diabetes foot complications. As nurses play a key role in wound care, their knowledge and attitudes are important in providing optimum care to patients. DESIGN: Descriptive cross sectional survey design...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28617792/simultaneous-bilateral-snowboarder-s-fractures-in-a-young-woman-a-rare-entity
#14
Avajit Barai, Ralph Scorgie, Bruce Lambie
BACKGROUND: Talus is a well-supported bone in the foot. A fracture of talus requires a high-impact injury. A wedge-shaped inferolateral component is the lateral process of the talus (LPT). A fracture of LPT is also known as a 'snowboarder's fracture'. Simultaneous bilateral snowboarder's fracture is rarely reported in English literature. CASE: We present here a case of simultaneous bilateral snowboarder's fractures in a slow-moving motor vehicle accident in the icy conditions...
June 16, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28617050/complications-following-operatively-treated-ankle-fractures-in-insulin-and-non-insulin-dependent-diabetic-patients
#15
Kevin P Haddix, R Carter Clement, Joshua N Tennant, Robert F Ostrum
BACKGROUND: Diabetics with ankle fractures experience more complications than the general population, but it is unclear whether complications differ between type 1 and 2 diabetics and between insulin- and non-insulin-dependent diabetics. This study aims to determine if there is a difference in postoperative complication rates between these groups. METHODS: An administrative health care database from a large commercial insurer was queried to identify operatively treated ankle fractures in patients with type 1 (T1D), type 2 (T2D), type 2 insulin-dependent (T2ID), and type 2 non-insulin-dependent (T2NID) diabetes...
June 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28614212/phosphaturic-mesenchymal-tumors-clinicopathologic-immunohistochemical-and-molecular-analysis-of-22-cases-expanding-their-morphologic-and-immunophenotypic-spectrum
#16
Abbas Agaimy, Michael Michal, Simion Chiosea, Fredrik Petersson, Ladislav Hadravsky, Glenn Kristiansen, Raymund E Horch, Jan Schmolders, Arndt Hartmann, Florian Haller, Michal Michal
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount of FGF23 which results in TIO via uncontrolled renal loss of phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have been reported. Although there is increasing evidence that PMT can be diagnosed by reproducible histopathologic features, firm diagnosis has been often restricted to cases associated with TIO and, hence, diagnosis of "nonphosphaturic variants" remained challenging...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28613416/topical-antimicrobial-agents-for-treating-foot-ulcers-in-people-with-diabetes
#17
REVIEW
Jo C Dumville, Benjamin A Lipsky, Christopher Hoey, Mario Cruciani, Marta Fiscon, Jun Xia
BACKGROUND: People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Topical antimicrobial therapy has been used on diabetic foot ulcers, either as a treatment for clinically infected wounds, or to prevent infection in clinically uninfected wounds...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28612249/autologous-structural-iliac-bone-grafts-in-reconstructions-of-short-bone-defects-in-the-hand-and-foot-after-primary-bone-tumor-resections-a-single-institution-retrospective-study
#18
J Lesensky, K Nemec, I Kofranek, Z Matejovsky
The use of structural autografts from the iliac crest for reconstruction of bony defects in the hand and foot was described by Wilson and Lance in 1965. However, very few series of this technique are published and long-term results are unknown. We present a single-institution series of 23 patients with a mean follow-up of 92 months. We also describe a novel modification of this technique using the anterior superior iliac spine for reconstruction of the adjacent joint. Failure rate was 13% at mean of 17.3 months...
June 13, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28611547/a-novel-heterozygous-intragenic-sequence-variant-in-dlx6-probably-underlies-first-case-of-autosomal-dominant-split-hand-foot-malformation-type-1
#19
Asmat Ullah, Anam Hammid, Muhammad Umair, Wasim Ahmad
Split-hand and foot malformation (SHFM; MIM 183600) is a rare human genetic limb malformation. It is characterized by missing digital rays in the hands and feet. SHFMs vary in severity from mild abnormalities affecting a single limb to acute malformations involving all 4 limbs. It is inherited, as part of both a syndromic and nonsyndromic disorder, in an autosomal recessive, autosomal dominant, and X-linked patterns. So far, 9 loci of hand and foot malformation have been mapped on human chromosomes. The present study describes a family with 2 affected individuals segregating SHFM in an autosomal dominant fashion...
March 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28608509/deprivation-and-healthy-food-access-cost-and-availability-a-cross-sectional-study
#20
S Williamson, M McGregor-Shenton, B Brumble, B Wright, C Pettinger
BACKGROUND: Food access, cost and availability have been identified as determinants of dietary choice. It has been suggested that these are socio-economically patterned; however, the evidence is inconclusive. The present study investigated whether differences exist with respect to healthy food access, cost and availability between areas of contrasting deprivation. METHODS: An ecological, cross-sectional study was conducted in two of the most and two of the least deprived wards in Plymouth...
June 13, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
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