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https://www.readbyqxmd.com/read/28326868/a-longitudinal-study-assessing-the-maintenance-condition-of-cadres-of-four-types-of-wheelchairs-provided-in-low-resource-areas
#1
Karen Rispin, Kristofer Riseling, Joy Wee
Wheelchair breakdowns increase the risk of injury and limit the mobility of wheelchair users. In the endeavour to meet the enormous global need for wheelchairs, manufacturers of wheelchairs for low-resource settings face a cost-benefit tension between affordability and durability. Field studies are needed to provide feedback on durability. Four manufacturers provided cadres of wheelchairs to the organization providing rehabilitation to students at a boarding school for children with disabilities in a low-resource area...
March 22, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28326159/effects-of-weight-bearing-exercise-on-a-mini-trampoline-on-foot-mobility-plantar-pressure-and-sensation-of-diabetic-neuropathic-feet-a-preliminary-study
#2
Wararom Kanchanasamut, Praneet Pensri
Objective: Foot and ankle exercise has been advocated as a preventative approach in reducing the risk of foot ulceration. However, knowledge about the appropriate types and intensity of exercise program for diabetic foot ulcer prevention is still limited. The current study aimed to examine the effects of an eight-week mini-trampoline exercise on improving foot mobility, plantar pressure and sensation of diabetic neuropathic feet. Methods: Twenty-one people with diabetic peripheral neuropathy who had impaired sensation perception were divided into two groups...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28325064/diabetic-foot-complications-despite-successful-pancreas-transplantation
#3
Dong-Kyo Seo, Ho Seong Lee, Jungu Park, Chang Hyun Ryu, Duck Jong Han, Sang Gyo Seo
BACKGROUND: It is known that successful pancreas transplantation enables patients with diabetes to maintain a normal glucose level without insulin and reduces diabetes-related complications. However, we have little information about the foot-specific morbidity in patients who have undergone successful pancreas transplantation. The purpose of this study was to investigate the prevalence and predisposing factors for foot complications after successful pancreas transplantation. METHODS: This retrospective study included 218 patients (91 males, 127 females) who had undergone pancreas transplantation for diabetes...
March 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28324204/tibial-nerve-neuropathy-following-medial-opening-wedge-high-tibial-osteotomy-case-report-of-a-rare-technical-complication
#4
Young-Soo Shin, Hyun-Bo Sim, Jung-Ro Yoon
A 63-year-old woman developed tibial nerve injury caused by an overlong K wire and 4.5-mm cortical lag screw through the first distal hole below the osteotomy during medial opening-wedge high tibial osteotomy (HTO), leading to a lack of sensation on the sole of the foot with no disturbances in motor functions. The temporary lag screw in the first distal hole below the osteotomy is often inserted by an excessive length in order to compress the potentially fractured opposite cortex. By doing so, posterior neurovascular structures including the tibial nerve and the popliteal vessels can be injured...
March 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28322918/favipiravir-can-evoke-lethal-mutagenesis-and-extinction-of-foot-and-mouth-disease-virus
#5
Ana Isabel de Avila, Elena Moreno, Celia Perales, Esteban Domingo
Antiviral agents are increasingly considered an option for veterinary medicine. An understanding of their mechanism of activity is important to plan their administration either as monotherapy or in combination with other agents. Previous studies have shown that the broad spectrum antiviral agent favipiravir (T-705) and its derivatives T-1105 and T-1106 are efficient inhibitors of foot-and-mouth disease virus (FMDV) replication in cell culture and in vivo. However, no mechanism for their activity against FMDV has been proposed...
March 17, 2017: Virus Research
https://www.readbyqxmd.com/read/28322011/fcrav2-a-gene-with-rogdi-domain-involved-in-fusarium-head-blight-and-crown-rot-on-durum-wheat-caused-by-fusarium-culmorum
#6
Francesca Spanu, Barbara Scherm, Irene Camboni, Virgilio Balmas, Giovanna Pani, Safa Oufensou, Nicolo' Macciotta, Matias Pasquali, Quirico Migheli
Fusarium culmorum is a soil-borne fungal pathogen able to cause foot and root rot and Fusarium head blight on small grain cereals, particularly on wheat and barley. It causes significant yield and quality loss and results in the contamination of kernels with type B trichothecene mycotoxins. Knowledge on pathogenicity factors of this fungus is still limited. A transposon tagging approach based on the mimp1/impala double component system has allowed us to select a mutant altered in multiple metabolic and morphological processes, trichothecene production and virulence...
March 21, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28315756/interleukin-4-is-a-participant-in-the-regulation-of-depressive-like-behavior
#7
Simone Wachholz, Alexandra Knorr, Leonie Mengert, Jennifer Plümper, Rainer Sommer, Georg Juckel, Astrid Friebe
Inflammatory immune activation has been frequently associated with the development of major depression. Microglia might serve as an important interface in this immune system-to-brain communication. Interleukin-4, the major Th2 type cytokine, might be protective against depression due to its ability to counter-regulate inflammation and to inhibit serotonin transporter activity. By using an Interferon-α mouse model, we show that a decreased IL-4 responsiveness of microglia was specifically related to the development of depressive-like behavior...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28315707/combined-administration-of-synthetic-rna-and-a-conventional-vaccine-improves-immune-responses-and-protection-against-foot-and-mouth-disease-virus-in-swine
#8
Belén Borrego, Esther Blanco, Miguel Rodríguez Pulido, Francisco Mateos, Gema Lorenzo, Sabrina Cardillo, Eliana Smitsaart, Francisco Sobrino, Margarita Sáiz
Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious disease and a major concern in animal health worldwide. We have previously reported the use of RNA transcripts mimicking structural domains in the non-coding regions of the FMDV RNA as potent type-I interferon (IFN) inducers showing antiviral effect in vivo, as well as their immunomodulatory properties in combination with an FMD vaccine in mice. Here, we describe the enhancing effect of RNA delivery on the immunogenicity and protection induced by a suboptimal dose of a conventional FMD vaccine in pigs...
March 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28314538/frequency-and-pattern-of-chronic-complications-of-diabetes-and-their-association-with-glycemic-control-among-adults-with-type-2-diabetes-in-bangladesh
#9
Shahjada Selim
BACKGROUND: The study was conducted in diabetes care centers to explore association of chronic complications of diabetes with glycemic status along with their frequency and pattern among adult patients with type 2 diabetes. METHODS: A cross-sectional study was conducted at outpatient departments of eight diabetes care centers in Dhaka. Data were collected by face to face interview by trained research physicians. Disease related information was recorded in the checklist from diabetes guide books of the patients...
March 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28298597/sat2-foot-and-mouth-disease-virus-fmdv-structurally-modified-for-increased-thermostability
#10
Katherine A Scott, Abhay Kotecha, Julian Seago, Jingshan Ren, Elizabeth E Fry, David I Stuart, Bryan Charleston, Francois F Maree
Foot-and-mouth disease virus (FMDV) is notoriously unstable, particularly the O and SAT serotypes. Consequently, vaccines derived from heat-labile SAT viruses have been linked to the induction of poor duration immunity and hence require more frequent vaccinations to ensure protection. In-silico calculations predicted residue substitutions that would increase interactions at the inter-pentameric interface supporting increased stability. We assessed the stability of the 18 recombinant mutant viruses for their growth kinetics; antigenicity; plaque morphology; genetic stability; temperature, ionic and pH stability using the thermofluor and inactivation assays, in order to evaluate potential SAT2 vaccine candidates with improved stability...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28297693/-a-case-of-central-type-disc-herniation-at-the-c7-t1-level-presenting-with-myelopathy
#11
Masatoshi Yunoki, Takahiro Kanda, Kenta Suzuki, Atsuhito Uneda, Koji Hirashita, Kimihiro Yoshino
In contrast to other levels of upper disc spaces, the Luschka joints are usually absent at the C7/T1 disc space. Therefore, it has been reported that the C7/T1 disc herniation is prone to herniate laterally rather than centrally. In this manuscript, we describe an extremely rare central-type disc herniation at the C7/T1 level presented with myelopathy. A 76-year-old man presented with a 20-day history of progressive gait disturbance. Physical examination revealed bilateral lower extremity hyperreflexia and mild foot numbness with no upper extremity motor weakness or sensory disturbance...
March 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28295608/incidence-and-anatomical-variations-of-accessory-navicular-bone-in-patients-with-foot-pain-a-retrospective-radiographic-analysis
#12
Heba Kalbouneh, Omar Alajoulin, Mohammad Alsalem, Noor Humoud, Jamil Shawaqfeh, Mohammad Alkhoujah, Hana Abu-Hassan, Waleed Mahafza, Darwish Badran
INTRODUCTION: The accessory navicular (AN) is an accessory ossicle anatomically located on the medial side of the foot, proximal to the navicular and continuous with the tibialis posterior tendon. It is occasionally a source of pain and local tenderness. Knowledge of the AN and its morphological variations can help identify the source of a patient's symptoms and prevent misinterpreting them as fractures. MATERIALS AND METHODS: Foot radiographs from 1240 patients who presented in two centers with chronic foot pain, or persistent pain developed after trauma, were retrospectively reviewed to determine the incidence and variations of the AN in relation to gender...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28294565/ankle-pathologies-in-patients-with-inflammatory-rheumatic-diseases-a-clinical-and-ultrasonographic-study
#13
Halil Harman, İbrahim Tekeoğlu
AIM: We determined ankle pathologies in patients with different types of inflammatory rheumatic diseases using high-resolution ultrasonographic (US) images, and compared the findings among the different patient groups. METHODS: The study included 142 randomly selected inflammatory rheumatic disease patients with clinically swollen or painful ankle joints; 69 patients had rheumatoid arthritis (RA), 58 had spondyloarthropathies (SpA) and 15 had gout. Ankle assessment on US included all of the important anatomical structures...
March 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28283002/losing-a-foot-versus-losing-a-dollar-a-systematic-review-of-cost-studies-in-diabetic-foot-complications
#14
Ioannis Petrakis, Ilias J Kyriopoulos, Alexandros Ginis, Kostas Athanasakis
Diabetes mellitus is a chronic disease with high prevalence worldwide and a range of serious related complications. Amongst them, diabetic foot is one of the most disabling, posing a substantial health and economic burden on patients and healthcare systems. Areas Covered: According to projections, the expected lower limb morbidity is about to increase - in this light the present review aimed at identifying cost-of-illness studies on the management and treatment of conditions related to the diabetic foot, in an aim to provide a body of evidence for an increasing health care burden...
March 10, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28281304/variations-in-sural-nerve-formation-pattern-and-distribution-on-the-dorsum-of-the-foot
#15
Su Kyoung Jeon, Doo-Jin Paik, Young-Il Hwang
The sural nerve, a cutaneous nerve, is clinically important because it is frequently for nerve conduction testing, biopsy, and harvesting for nerve grafts. This nerve exhibits a wide variety of variation in formation, distribution on the dorsum of the foot, and so on, depending on the population observed. In this study, we examined the variation in the sural nerve in 110 Korean cadavers. Of these cadavers, 86.1% of the sural nerves corresponded to type A, where tibial and peroneal components were united to form the sural nerve...
March 9, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28280845/-function-of-prosthesis-components-in-lower-limb-amputees-with-bone-anchored-percutaneous-implants-biomechanical-aspects
#16
S Blumentritt
BACKGROUND: Bone anchorage of an artificial limb has been proven to be an alternative intervention for amputees when prosthesis use is seriously reduced because of stump problems. Little is known about how prosthesis components interact with bone and joints and which potential the optimum use provides with respect to quality of treatment of leg amputees. OBJECTIVE: Does osseointegration influence the motor activity of residual limbs differently compared with socket prostheses? How should prosthesis components be aligned? What type of prosthetic knee joints should be preferred in transfemoral amputees? MATERIAL AND METHODS: Transfer of biomechanical knowledge of socket prosthetics to bone-anchored prostheses...
March 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28278253/reduced-bone-formation-markers-and-altered-trabecular-and-cortical-bone-mineral-densities-of-non-paretic-femurs-observed-in-rats-with-ischemic-stroke-a-randomized-controlled-pilot-study
#17
Karen N Borschmann, Sarah S Rewell, Sandra Iuliano, Ali Ghasem-Zadeh, Rachel A Davey, Heidi Ho, Peta N Skeers, Julie Bernhardt, David W Howells
BACKGROUND: Immobility and neural damage likely contribute to accelerated bone loss after stroke, and subsequent heightened fracture risk in humans. OBJECTIVE: To investigate the skeletal effect of middle cerebral artery occlusion (MCAo) stroke in rats and examine its utility as a model of human post-stroke bone loss. METHODS: Twenty 15-week old spontaneously hypertensive male rats were randomized to MCAo or sham surgery controls. Primary outcome: group differences in trabecular bone volume fraction (BV/TV) measured by Micro-CT (10...
2017: PloS One
https://www.readbyqxmd.com/read/28274803/the-effect-of-orexin-1-and-orexin-2-receptors-antagonisms-in-the-basolateral-amygdala-on-memory-processing-in-a-passive-avoidance-task
#18
Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari
There is an extensive evidence concerning basolateral amygdala (BLA) function to hippocampal memory processing. However, few researches have addressed the orexinergic system roles in this modulation. Then, the present study aims at investigating the action of orexin 1 and 2 receptors in BLA on passive avoidance (PA) learning. Wistar male rats (n=79) were trained to avoid foot shock in one type of PA task. The rats were injected bilaterally into BLA, a selective orexin 1 receptor antagonist, SB-334867-A (3, 6, 12μg/0...
March 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28272013/when-traditional-offloading-is-not-an-option-could-an-external-fixator-be-a-solution-a-case-report
#19
Abdulaziz A Kimawi, Robert J Snyder, Mario A Cala, Cherison Cuffy
Offloading is a cornerstone in managing diabetic plantar foot ulcers; however, it often represents one of the most challenging aspects of treatment for clinician and patient alike. The authors present a case of a 61-year-old African American man with type 2 diabetes and a limb-threatening plantar foot ulcer that required aggressive wound and surgical management. Due to the heavy drainage and patient adherence issues, traditional offloading techniques such as total contact cast, DH Pressure Relief Walker (Össur, Foothill Ranch, CA), and wedge shoes, among others, were not viable options...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28271932/mid-term-results-of-minimally-invasive-plate-osteosynthesis-and-circular-external-fixation-in-the-treatment-of-complex-distal-tibia-fractures
#20
Yunus Imren, Engin Eren Desteli, Mehmet Erdil, Hasan Hüseyin Ceylan, Ibrahim Tuncay, Cengiz Sen
BACKGROUND: The treatment of pilon tibia fractures is challenging. Anatomical reduction of the joint surface is essential. Excessive soft-tissue dissection may interfere with the blood supply and can result in nonunion. We sought to compare the outcomes of distal tibia fractures treated with medial locking plates versus circular external fixators. METHODS: We retrospectively evaluated 41 consecutive patients with closed pilon tibia fractures treated with either minimally invasive locking plate osteosynthesis (n = 21) or external fixation (EF) (n = 20)...
January 2017: Journal of the American Podiatric Medical Association
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