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https://www.readbyqxmd.com/read/29244787/loss-of-podocalyxin-causes-a-novel-syndromic-type-of-congenital-nephrotic-syndrome
#1
Hee Gyung Kang, Moses Lee, Kyoung Boon Lee, Michael Hughes, Bo Sang Kwon, Sangmoon Lee, Kelly M McNagny, Yo Han Ahn, Jung Min Ko, Il-Soo Ha, Murim Choi, Hae Il Cheong
Many cellular structures directly imply specific biological functions. For example, normal slit diaphragm structures that extend from podocyte foot processes ensure the filtering function of renal glomeruli. These slits are covered by a number of surface proteins, such as nephrin, podocin, podocalyxin and CD2AP. Here we report a human patient presenting with congenital nephrotic syndrome, omphalocele and microcoria due to two loss-of-function mutations in PODXL, which encodes podocalyxin, inherited from each parent...
December 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29242313/dissection-of-glomerular-transcriptional-profile-in-patients-with-diabetic-nephropathy-srgap2a-protects-podocyte-structure-and-function
#2
Yu Pan, Song Jiang, Qing Hou, Dandan Qiu, Jingsong Shi, Ling Wang, Zhaohong Chen, Mingchao Zhang, Aiping Duan, Weisong Qin, Ke Zen, Zhihong Liu
Podocytes play a pivotal role in maintaining glomerular filtration function through their interdigitated foot processes. However, the mechanisms that govern the podocyte cytoskeletal rearrangement still remain unclear. Through analyzing transcriptional profile of renal biopsy from diabetic nephropathy (DN) patients and control donors, we identify Slit-Robo GTP activating protein 2a (SRGAP2a) as one of the main 'hub' genes that are strongly associated with proteinuria and glomerular filtration in type 2 DN patients...
December 14, 2017: Diabetes
https://www.readbyqxmd.com/read/29241099/perceptual-motor-regulation-in-locomotor-pointing-while-approaching-a-curb
#3
Steven van Andel, Michael H Cole, Gert-Jan Pepping
Locomotor pointing is a task that has been the focus of research in the context of sport (e.g. long jumping and cricket) as well as normal walking. Collectively, these studies have produced a broad understanding of locomotor pointing, but generalizability has been limited to laboratory type tasks and/or tasks with high spatial demands. The current study aimed to generalize previous findings in locomotor pointing to the common daily task of approaching and stepping on to a curb. Sixteen people completed 33 repetitions of a task that required them to walk up to and step onto a curb...
December 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29240733/use-of-tai-fish-to-visualize-neural-ensembles-activated-by-multiple-stimuli
#4
Qi Zhang, Qiye He, Jihua Wang, Chaoying Fu, Hailan Hu
Researchers in behavioral neuroscience have long sought imaging techniques that can identify and distinguish neural ensembles that are activated by sequentially applied stimuli at single-cell resolution across the whole brain. Taking advantage of the different kinetics of immediate-early genes' mRNA and protein expression, we addressed this problem by developing tyramide-amplified immunohistochemistry-fluorescence in situ hybridization (TAI-FISH), a dual-epoch neural-activity-dependent labeling protocol. Here we describe the step-by-step procedures for TAI-FISH on brain sections from mice that were sequentially stimulated by morphine (appetitive first stimulus) and foot shock (aversive second stimulus)...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29239782/the-morphology-of-foot-soft-tissues-is-associated-with-running-shoe-type-in-healthy-recreational-runners
#5
Xianyi Zhang, Tijs Delabastita, Joselien Lissens, Floor De Beenhouwer, Benedicte Vanwanseele
OBJECTIVES: To determine the differences in the morphology of foot soft tissues between runners using different types of running shoes. DESIGN: Cross-sectional study. METHODS: Thirty-eight recreational runners were divided into four groups based on running shoe type, namely, neutral shoes, motion control shoes, minimalistic shoes and neutral shoes with custom-made insoles. An arch height index and a relative arch deformation index were calculated for each participant...
November 22, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29238034/inverse-relationship-between-serum-bilirubin-levels-and-diabetic-foot-in-chinese-patients-with-type-2-diabetes-mellitus
#6
Jifan Chen, Jian Wang, Xingxing Zhang, Hong Zhu
BACKGROUND Several studies demonstrated that bilirubin, a potent endogenous antioxidant, is a strong protective factor for many diabetic complications such as nephropathy, retinopathy, neuropathy, and vasculopathy. The purpose of this study was to assess the association between serum bilirubin levels and diabetic foot (DF) in Chinese patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS The present cross-sectional study of bilirubin levels in relation to DF was conducted in 1,269 T2DM patients with (n=578) and without (n=691) DF...
December 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29235129/association-of-gene-polymorphisms-of-pattern-recognition-receptor-signalling-pathway-with-the-risk-and-severity-of-hand-foot-and-mouth-disease-caused-by-enterovirus-71-in-chinese-han-population
#7
Ya-Ping Li, Mei Li, Xiao-Li Jia, Hui-Ling Deng, Wen-Jun Wang, Feng-Ping Wu, Jun Wang, Shuang-Suo Dang
Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex- and age-matched children was included as a control...
December 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29233744/a-flavonoid-compound-library-screen-revealed-potent-antiviral-activity-of-plant-derived-flavonoids-on-human-enterovirus-a71-replication
#8
Nyo Min, Leong Pok Thim, Regina Ching Hua Lee, Jeffery Seng Eng Khuan, Justin Jang Hann Chu
Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71 infection. In this study, a 500-compound flavonoid library was screened to identify potential inhibitors of HEVA71 using high-throughput immunofluorescence-based phenotypic screening method. Two lead flavonoid compounds, ST077124 and ST024734 at the non-cytotoxic concentration of 50 μM were found to be effective antivirals that inhibited replication of HEVA71, reducing infectious viral titers by 3...
December 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29231784/feet-kinematics-upon-slipping-discriminate-between-recoveries-and-three-types-of-slip-induced-falls
#9
Leigh J Allin, Maury A Nussbaum, Michael L Madigan
This study investigated the relationship between feet kinematics upon slipping while walking and the outcome of the slip. Seventy-one slips (induced by walking over an unexpectedly slippery surface) were analysed, which included 37 recoveries, 16 feet-split falls, 11 feet-forward falls, and seven lateral falls. Feet kinematics differed between these four slip outcomes, and a discriminant model including six measures of feet kinematics correctly predicted 87% of slip outcomes. Two potentially modifiable characteristics of the feet kinematics upon slipping that can improve the likelihood of successfully averting a fall were identified: (1) quickly arresting the motion of the slipping foot; and (2) a recovery step that places the trailing toe approximately 0-10% body height anterior to the sacrum...
December 12, 2017: Ergonomics
https://www.readbyqxmd.com/read/29230289/accessory-anterolateral-talar-facet-impingement-with-tibialis-spastic-varus-foot
#10
Toshinori Kurashige
In recent years, some authors have reported accessory anterolateral talar facet impingement with flatfoot including peroneal spastic flatfoot. Conversely, to our knowledge, no case report has been published about accessory anterolateral talar facet impingement with tibialis spastic varus foot. We report the first case in a 22-year-old man with intellectual disability, bilateral cleft hands and type 1 diabetes mellitus. Since spraining his left ankle over a year earlier, he experienced left sinus tarsi pain while standing and walking...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29228848/comparative-study-of-surgical-and-conservative-treatments-for-fifth-metatarsal-base-avulsion-fractures-type-i-in-young-adults-or-athletes
#11
Gen-Bin Wu, Bing Li, Yun-Feng Yang
PURPOSE: This study aimed to investigate the therapeutic effects and complications of minimally invasive surgery in treating displaced avulsion fractures (2-3 mm) of fifth metatarsal base zone I in young adults or athletes. METHODS: Forty-six patients with displaced fifth metatarsal base avulsion fractures were assigned to operative and nonoperative groups by randomization. Patients in nonoperative group were immobilized with plaster, while patients in operative group were treated with closed reduction and fixation with a percutaneous screw...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29228800/fifth-metatarsal-jones-fractures-in-the-athlete
#12
David A Porter
Fifth metatarsal fractures, otherwise known as "Jones" fractures, occur commonly in athletes and nonathletes alike. While recent occurrence in the popular elite athlete has increased public knowledge and interest in the fracture, this injury is common at all levels of sport. This review will focus on all three types of Jones fractures. The current standard for treatment is operative intervention with intramedullary screw fixation. Athletes typically report an acute episode of lateral foot pain, described as an ache...
December 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29224059/lower-complication-rate-and-faster-return-to-sports-in-patients-with-acute-syndesmotic-rupture-treated-with-a-new-knotless-suture-button-device
#13
Christian Colcuc, Marc Blank, Thomas Stein, Florian Raimann, Sanjay Weber-Spickschen, Sebastian Fischer, Reinhard Hoffmann
PURPOSE: Suture button devices for tibiofibular syndesmosis injuries provide semirigid dynamic stabilization, but complications including knot irritation have been reported. No randomized trials of the new knotless suture button devices have been performed. We hypothesized that knotless suture button devices eliminate knot irritation and facilitate quicker return to sports. This study was performed to compare the clinical outcomes, complication rates, and time to return to sports between a new knotless suture button device and syndesmotic screw fixation...
December 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29220878/a-qualitative-study-of-the-experience-of-lower-extremity-wounds-and-amputations-among-people-with-diabetes-in-philadelphia
#14
Frances K Barg, Peter F Cronholm, Ebony E Easley, Trocon Davis, Michelle Hampton, D Scot Malay, Cornelius Donohue, Jinsup Song, Stephen R Thom, David J Margolis
The purpose of this study was to explore perceptions among people with type 2 diabetes about foot ulcers and lower extremity amputations. This was a qualitative observational study utilizing open-ended, semistructured interviews of 39 people with diabetes who were purposively selected because they had either a foot ulcer (n = 19) or a lower extremity amputation (n = 20). Interviews were audio-recorded, deidentified, and entered into NVivo 10.0 for coding and analysis. Our integrated analytic approach combined inductively and deductively derived codes that were applied to all transcripts...
December 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29216768/a-mysterious-case-of-complex-regional-pain-syndrome-in-a-9-year-old-girl
#15
Angela Burian, Othmar Schuhfried, Richard Crevenna
PURPOSE: To describe the clinical manifestation and the treatment of complex regional pain syndrome type II in childhood. METHODS: Using information on the symptoms, diagnosis, rehabilitation and outcome of a young patient with complex regional pain syndrome type II. RESULTS: A 9-year -old girl had severe pain in the region of the left foot, signs of a common fibular nerve entrapment, hyperalgesia not limited to the distribution of the injured nerve, weakness and temperature asymmetry unknown origin...
December 7, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29215738/electronic-cigarette-a-recent-update-of-its-toxic-effects-on-humans
#16
REVIEW
Shu-Jie Huang, Yan-Ming Xu, Andy T Y Lau
Electronic cigarettes (e-cigarettes), battery-powered and liquid-vaporizing devices, were invented to replace the conventional cigarette (c-cigarette) smoking for the sake of reducing the adverse effects on multiple organ systems that c-cigarettes have induced. Although some of the identified harmful components in e-cigarettes were alleged to be measured in lower quantity than those in c-cigarettes, researchers unveiled that the toxic effects of e-cigarettes should not be understated. This review is sought for an attempt to throw light on several typical types of e-cigarette components (tobacco-specific nitrosamines, carbonyl compounds, and volatile organic compounds) by revealing their possible impacts on human bodies through different action mechanisms characterized by alteration of specific biomarkers on cellular and molecular levels...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29214210/excitatory-synaptic-input-to-hilar-mossy-cells-under-basal-and-hyperexcitable-conditions
#17
Tristan P Hedrick, William P Nobis, Kendall M Foote, Toshiyuki Ishii, Dane M Chetkovich, Geoffrey T Swanson
Hilar mossy cells (HMCs) in the hippocampus receive glutamatergic input from dentate granule cells (DGCs) via mossy fibers (MFs) and back-projections from CA3 pyramidal neuron collateral axons. Many fundamental features of these excitatory synapses have not been characterized in detail despite their potential relevance to hippocampal cognitive processing and epilepsy-induced adaptations in circuit excitability. In this study, we compared pre- and postsynaptic parameters between MF and CA3 inputs to HMCs in young and adult mice of either sex and determined the relative contributions of the respective excitatory inputs during in vitro and in vivo models of hippocampal hyperexcitability...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29211958/core-shell-yarn-based-triboelectric-nanogenerator-textiles-as-power-cloths
#18
Aifang Yu, Xiong Pu, Rongmei Wen, Mengmeng Liu, Tao Zhou, Ke Zhang, Yang Zhang, Junyi Zhai, Weiguo Hu, Zhong Lin Wang
Although textile-based triboelectric nanogenerators (TENG) are highly promising as they scavenging energy from their working environment for sustainable powering wearable/mobile electronics, it remains a challenge to simultaneously possess the qualities of cloths. In this work, we propose strategy for TENG textiles as energy harvesting cloths that core-shell yarns, with core conductive fibers as the electrode and artificial polymer fibers or natural fibrous materials tightly twinning around core conductive fibers as the triboelectrification layer, are applied as the building blocks...
December 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/29208058/low-protein-diet-supplemented-with-ketoacids-delays-the-progression-of-diabetic-nephropathy-by-inhibiting-oxidative-stress-in-the-kkay-mice-model
#19
Dongmei Liu, Ming Wu, Lin Li, Xiang Gao, Bo Yang, Shuqin Mei, Lili Fu, Changlin Mei
Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone...
December 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29207011/astragaloside-iv-prevents-kidney-injury-caused-by-iatrogenic-hyperinsulinemia-in-a-streptozotocin%C3%A2-induced-diabetic-rat-model
#20
Ke-Qiang He, Wei-Zu Li, Xiao-Qing Chai, Yan-Yan Yin, Yan Jiang, Wei-Ping Li
Diabetic patients are able to manage their blood glucose with exogenous insulin but, ultimately, remain at risk of diabetic nephropathy (DN). Long‑term use of insulin may lead to iatrogenic hyperinsulinemia, which has been suggested to cause kidney injury. However, there are no effective interventions for iatrogenic hyperinsulinemia leading to kidney damage. In the present paper, the hypothesis that astragaloside IV (AS‑IV), a novel saponin purified from Astragalus membranaceus (Fisch) Bunge, may prevent DN in iatrogenic hyperinsulinemic diabetic rats through antioxidative and anti‑inflammatory mechanisms was investigated...
November 17, 2017: International Journal of Molecular Medicine
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