Shobi Sivathamboo, Daniel Friedman, Juliana Laze, Russell Nightscales, Zhibin Chen MBiostat, Levin Kuhlmann, Sasha Devore, Vaughan Macefield, Patrick Kwan, Wendyl D'Souza, Samuel F Berkovic, Piero Perucca, Terence J O'Brien, Orrin Devinsky
OBJECTIVE: We compared heart rate variability (HRV) in sudden unexpected death in epilepsy (SUDEP) cases and living epilepsy controls. METHODS: This international, multicenter, retrospective, nested case-control study examined patients admitted for video-EEG monitoring (VEM) between January 1, 2003 and December 31, 2014, and subsequently died of SUDEP. Time-domain and frequency-domain components were extracted from five-minute interictal electrocardiogram recordings during sleep and wakefulness from SUDEP cases and controls...
October 14, 2021: Neurology