keyword
https://read.qxmd.com/read/36768918/evaluation-of-the-antiseizure-activity-of-endemic-plant-halfordia-kendack-guillaumin-and-its-main-constituent-halfordin-on-a-zebrafish-pentylenetetrazole-ptz-induced-seizure-model
#21
JOURNAL ARTICLE
Adrianna Skiba, Ewelina Kozioł, Simon Vlad Luca, Barbara Budzyńska, Piotr Podlasz, Wietske Van Der Ent, Elham Shojaeinia, Camila V Esguerra, Mohammed Nour, Laurence Marcourt, Jean-Luc Wolfender, Krystyna Skalicka-Woźniak
Epilepsy is a neurological disease that burdens over 50 million people worldwide. Despite the considerable number of available antiseizure medications, it is estimated that around 30% of patients still do not respond to available treatment. Herbal medicines represent a promising source of new antiseizure drugs. This study aimed to identify new drug lead candidates with antiseizure activity from endemic plants of New Caledonia. The crude methanolic leaf extract of Halfordia kendack Guillaumin (Rutaceae) significantly decreased (75 μg/mL and 100 μg/mL) seizure-like behaviour compared to sodium valproate in a zebrafish pentylenetetrazole (PTZ)-induced acute seizure model...
January 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36731682/higher-order-thalamic-nuclei-facilitate-the-generalization-and-maintenance-of-spike-and-wave-discharges-of-absence-seizures
#22
JOURNAL ARTICLE
Zoe Atherton, Olivér Nagy, Lívia Barcsai, Péter Sere, Nikolett Zsigri, Tamás Földi, Levente Gellért, Antal Berényi, Vincenzo Crunelli, Magor L Lőrincz
Spike-and-wave discharges (SWDs), generated by the cortico-thalamo-cortical (CTC) network, are pathological, large amplitude oscillations and the hallmark of absence seizures (ASs). SWDs begin in a cortical initiation network in both humans and animal models, including the Genetic Absence Epilepsy Rats from Strasbourg (GAERS), where it is located in the primary somatosensory cortex (S1). The behavioral manifestation of an AS occurs when SWDs spread from the cortical initiation site to the whole brain, however, the mechanisms behind this rapid propagation remain unclear...
March 2023: Neurobiology of Disease
https://read.qxmd.com/read/36630716/sensing-local-field-potentials-with-a-directional-and-scalable-depth-electrode-array
#23
JOURNAL ARTICLE
Amada M Abrego, Wasif Khan, Christopher E Wright, M Rabiul Islam, Mohammad H Ghajar, Xiaokang Bai, Nitin Tandon, John P Seymour
A variety of electrophysiology tools are available to the neurosurgeon for diagnosis, functional therapy, and neural prosthetics. However, no tool can currently address these three critical needs: (i) access to all cortical regions in a minimally invasive manner; (ii) recordings with microscale, mesoscale, and macroscale resolutions simultaneously; and (iii) access to spatially distant multiple brain regions that constitute distributed cognitive networks. We present a novel device for recording local field potentials (LFPs) with the form factor of a stereo-electroencephalographic electrode but combined with radially positioned microelectrodes and using the lead body to shield LFP sources, enabling directional sensitivity and scalability, referred to as the DISC array...
January 11, 2023: Journal of Neural Engineering
https://read.qxmd.com/read/36541427/the-role-of-selective-satb1-deletion-in-somatostatin-expressing-interneurons-on-endogenous-network-activity-and-the-transition-to-epilepsy
#24
JOURNAL ARTICLE
Nikos Vasilopoulos, Ani Kaplanian, Michael Vinos, Yolanda Katsaiti, Ourania Christodoulou, Myrto Denaxa, Irini Skaliora
Somatostatin (SST) expressing interneurons are the second most abundant group of inhibitory neurons in the neocortex. They mainly target the apical dendrites of excitatory pyramidal cells and are implicated in feedforward and feedback inhibition. In the present study, we employ a conditional knockout mouse, in which the transcription factor Satb1 is selectively deleted in SST-expressing interneurons resulting to the reduction of their number across the somatosensory barrel field. Our goal was to investigate the effect of the reduced number of Satb1 mutant SST-interneurons on (i) the endogenous cortical network activity (spontaneously recurring Up/Down states), and (ii) the transition to epileptiform activity...
December 21, 2022: Journal of Neuroscience Research
https://read.qxmd.com/read/36192155/low-cost-platform-for-multianimal-chronic-local-field-potential-video-monitoring-with-graphical-user-interface-gui-for-seizure-detection-and-behavioral-scoring
#25
JOURNAL ARTICLE
Gergely Tarcsay, Brittney Lee Boublil, Laura A Ewell
Experiments employing chronic monitoring of neurophysiological signals and video are commonly used in studies of epilepsy to characterize behavioral correlates of seizures. Our objective was to design a low-cost platform that enables chronic monitoring of several animals simultaneously, synchronizes bilateral local field potential (LFP) and video streams in real time, and parses recorded data into manageable file sizes. We present a hardware solution leveraging Intan and Open Ephys acquisition systems and a software solution implemented in Bonsai...
2022: ENeuro
https://read.qxmd.com/read/36081060/estimation-of-ant-dbs-electrodes-on-target-positioning-based-on-a-new-percept-tm-pc-lfp-signal-analysis
#26
JOURNAL ARTICLE
Elodie Múrias Lopes, Ricardo Rego, Manuel Rito, Clara Chamadoira, Duarte Dias, João Paulo Silva Cunha
Deep brain stimulation of the Anterior Nucleus of the Thalamus (ANT-DBS) is an effective therapy in epilepsy. Poorer surgical outcomes are related to deviations of the lead from the ANT-target. The target identification relies on the visualization of anatomical structures by medical imaging, which presents some disadvantages. This study aims to research whether ANT-LFPs recorded with the PerceptTM PC neurostimulator can be an asset in the identification of the DBS-target. For this purpose, 17 features were extracted from LFPs recorded from a single patient, who stayed at an Epilepsy Monitoring Unit for a 5-day period...
September 1, 2022: Sensors
https://read.qxmd.com/read/36034337/data-driven-network-dynamical-model-of-rat-brains-during-acute-ictogenesis
#27
JOURNAL ARTICLE
Victor Hugo Batista Tsukahara, Jordão Natal de Oliveira Júnior, Vitor Bruno de Oliveira Barth, Jasiara Carla de Oliveira, Vinicius Rosa Cota, Carlos Dias Maciel
Epilepsy is one of the most common neurological disorders worldwide. Recent findings suggest that the brain is a complex system composed of a network of neurons, and seizure is considered an emergent property resulting from its interactions. Based on this perspective, network physiology has emerged as a promising approach to explore how brain areas coordinate, synchronize and integrate their dynamics, both under perfect health and critical illness conditions. Therefore, the objective of this paper is to present an application of (Dynamic) Bayesian Networks (DBN) to model Local Field Potentials (LFP) data on rats induced to epileptic seizures based on the number of arcs found using threshold analytics...
2022: Frontiers in Neural Circuits
https://read.qxmd.com/read/35840521/vagus-nerve-stimulation-modulates-phase-amplitude-coupling-in-thalamic-local-field-potentials
#28
JOURNAL ARTICLE
Nebras M Warsi, Han Yan, Simeon M Wong, Ivanna Yau, Sara Breitbart, Cristina Go, Carolina Gorodetsky, Alfonso Fasano, Suneil K Kalia, James T Rutka, Kerry Vaughan, George M Ibrahim
OBJECTIVE: The antiseizure effects of vagus nerve stimulation (VNS) are thought to be mediated by the modulation of afferent thalamocortical circuitry. Cross-frequency phase-amplitude coupling (PAC) is a mechanism of hierarchical network coordination across multiple spatiotemporal scales. In this study, we leverage local field potential (LFP) recordings from the centromedian (CM) (n = 3) and anterior (ATN) (n = 2) nuclei in five patients with tandem thalamic deep brain stimulation and VNS to study neurophysiological changes in the thalamus in response to VNS...
July 12, 2022: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/35754505/adenosine-a-2a-receptor-signaling-plays-a-crucial-role-in-sudden-unexpected-death-in-epilepsy
#29
JOURNAL ARTICLE
Hai-Ying Shen, Sadie B Baer, Raey Gesese, John M Cook, Landen Weltha, Shayla Q Coffman, Jie Wu, Jiang-Fan Chen, Ming Gao, Teng Ji
Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of adenosine A2A receptor (A2A R) in the development of a SUDEP mouse model with relevant clinical features. Using a combined paradigm of intrahippocampal and intraperitoneal administration of kainic acid (KA), we developed a boosted-KA model of SUDEP in genetically modified adenosine kinase (ADK) knockdown (Adk+/- ) mice, which has reduced ADK in the brain...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35624482/gpr120-modulates-epileptic-seizure-and-neuroinflammation-mediated-by-nlrp3-inflammasome
#30
JOURNAL ARTICLE
Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü, Weihua Yu
BACKGROUND: The complex pathophysiology of epilepsy hampers the development of effective treatments. Although more than ten kinds of anti-seizures drugs (ASDs) have good effects on seizure control worldwide, about 30% of patients still display pharmacoresistance against ASDs. Neuroinflammation seems to play a crucial role in disease progression. G protein-coupled receptor 120 (GPR120) has been shown to negatively regulate inflammation and apoptosis. However, the role of GPR120 in epilepsy remains unclear...
May 27, 2022: Journal of Neuroinflammation
https://read.qxmd.com/read/35128516/the-type-1-cannabinoid-receptor-positive-allosteric-modulators-gat591-and-gat593-reduce-spike-and-wave-discharges-in-genetic-absence-epilepsy-rats-from-strasbourg
#31
JOURNAL ARTICLE
Dan L McElroy, Andrew J Roebuck, Quentin Greba, Sumanta Garai, Asher L Brandt, Orhan Yilmaz, Stuart M Cain, Terrance P Snutch, Ganesh A Thakur, Robert B Laprairie, John G Howland
Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist of 2.5-5 Hz spike-and-wave discharges (SWDs) detectable using electroencephalography (EEG). Current drug treatments are only partially effective and adverse side effects have spurred research into alternative treatment approaches. Recent research shows that positive allosteric modulation of the type-1 cannabinoid receptor (CB1R) reduces the frequency and duration of SWDs in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a model that recapitulates the SWDs in CAE...
June 2022: IBRO neuroscience reports
https://read.qxmd.com/read/35031048/long-term-in-vivo-application-of-a-potassium-channel-based-optogenetic-silencer-in-the-healthy-and-epileptic-mouse-hippocampus
#32
JOURNAL ARTICLE
P Kleis, E Paschen, U Häussler, Y A Bernal Sierra, C A Haas
BACKGROUND: Optogenetic tools allow precise manipulation of neuronal activity via genetically encoded light-sensitive proteins. Currently available optogenetic inhibitors are not suitable for prolonged use due to short-lasting photocurrents, tissue heating, and unintended changes in ion distributions, which may interfere with normal neuron physiology. To overcome these limitations, a novel potassium channel-based optogenetic silencer, named PACK, was recently developed. The PACK tool has two components: a photoactivated adenylyl cyclase from Beggiatoa (bPAC) and a cAMP-dependent potassium channel, SthK, which carries a large, long-lasting potassium current in mammalian cells...
January 14, 2022: BMC Biology
https://read.qxmd.com/read/34782347/seizure-prediction-in-genetic-rat-models-of-absence-epilepsy-improved-performance-through-multiple-site-cortico-thalamic-recordings-combined-with-machine-learning
#33
JOURNAL ARTICLE
Björn Budde, Vladimir Maksimenko, Kelvin Sarink, Thomas Seidenbecher, Gilles van Luijtelaar, Tim Hahn, Hans-Christian Pape, Annika Lüttjohann
Seizure prediction is the grand challenge of epileptology. However, effort was devoted to prediction of focal seizures, while generalized seizures were regarded as stochastic events. Long-lasting local field potential (LFP) recordings containing several hundred generalized spike and wave discharges (SWDs), acquired at eight locations in the cortico-thalamic system of absence epileptic rats, were iteratively analyzed in all possible combinations of either two or three recording sites, by a wavelet-based algorithm, calculating the product of the wavelet-energy signaling increases in synchronicity...
January 2022: ENeuro
https://read.qxmd.com/read/34742877/spatial-and-temporal-profile-of-high-frequency-oscillations-in-posttraumatic-epileptogenesis
#34
JOURNAL ARTICLE
Lin Li, Udaya Kumar, Jing You, Yufeng Zhou, Shennan A Weiss, Jerome Engel, Anatol Bragin
We studied the role of temporal and spatial changes in high-frequency oscillation (HFO, 80-500 Hz) generation in epileptogenesis following traumatic brain injury (TBI). Experiments were conducted on adult male Sprague Dawley rats. For the TBI group, fluid percussion injury (FPI) on the left sensorimotor area was performed to induce posttraumatic epileptogenesis. For the sham control group, only the craniotomy was performed. After TBI, 8 bipolar micro-electrodes were implanted bilaterally in the prefrontal cortex, perilesional area and homotopic contralateral site, striatum, and hippocampus...
December 2021: Neurobiology of Disease
https://read.qxmd.com/read/34720874/pericardial-injection-of-kainic-acid-induces-a-chronic-epileptic-state-in-larval-zebrafish
#35
JOURNAL ARTICLE
Lise Heylen, Duc-Hung Pham, Ann-Sofie De Meulemeester, Éric Samarut, Adrianna Skiba, Daniëlle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter A M de Witte, Aleksandra Siekierska
Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis. The mechanistic processes underlying the changes of brain tissue and networks toward increased seizure susceptibility are not fully understood. In rodents, injection of kainic acid (KA) ultimately leads to the development of spontaneous epileptic seizures, reflecting similar neuropathological characteristics as seen in patients with temporal lobe epilepsy (TLE)...
2021: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/34676980/g-alpha-interacting-protein-interacting-protein-c-terminus-1-regulates-epileptogenesis-by-increasing-the-expression-of-metabotropic-glutamate-receptor-7
#36
JOURNAL ARTICLE
Yong Liu, You Wang, Juan Yang, Tao Xu, Changhong Tan, Peng Zhang, Qiankun Liu, Yangmei Chen
AIMS: It has been reported that the G-alpha interacting protein (GAIP) interacting protein, C terminus 1 (GIPC1/GIPC) engages in vesicular trafficking, receptor transport and expression, and endocytosis. However, its role in epilepsy is unclear. Therefore, in this study, we aimed to explore the role of GIPC1 in epilepsy and its possible underlying mechanism. METHODS: The expression patterns of GIPC1 in patients with temporal lobe epilepsy (TLE) and in mice with kainic acid (KA)-induced epilepsy were detected...
January 2022: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/34649884/association-of-short-term-heart-rate-variability-and-sudden-unexpected-death-in-epilepsy
#37
JOURNAL ARTICLE
Shobi Sivathamboo, Daniel Friedman, Juliana Laze, Russell Nightscales, Zhibin Chen MBiostat, Levin Kuhlmann, Sasha Devore, Vaughan Macefield, Patrick Kwan, Wendyl D'Souza, Samuel F Berkovic, Piero Perucca, Terence J O'Brien, Orrin Devinsky
OBJECTIVE: We compared heart rate variability (HRV) in sudden unexpected death in epilepsy (SUDEP) cases and living epilepsy controls. METHODS: This international, multicenter, retrospective, nested case-control study examined patients admitted for video-EEG monitoring (VEM) between January 1, 2003 and December 31, 2014, and subsequently died of SUDEP. Time-domain and frequency-domain components were extracted from five-minute interictal electrocardiogram recordings during sleep and wakefulness from SUDEP cases and controls...
October 14, 2021: Neurology
https://read.qxmd.com/read/34647906/feasibility-study-on-transcutaneous-auricular-vagus-nerve-stimulation-using-millimeter-waves
#38
JOURNAL ARTICLE
Hi Yuen Song, Dong Woo Shin, Seung Moon Jung, Yong Jeong, Bumseok Jeong, Chul Soon Park
Objective . Electrical stimulation of the auricular vagus nerve is a non-invasive neuromodulation technique that has been used for various conditions, including depression, epilepsy, headaches, and cerebral ischemia. However, unwanted non-vagal nerve stimulations can occur because of diffused stimulations. The objective of this study is to develop a region-specific non-invasive vagus nerve stimulation (VNS) technique using the millimeter wave (MMW) as a stimulus for the auricular branch of the vagus nerve (ABVN)...
October 13, 2021: Biomedical Physics & Engineering Express
https://read.qxmd.com/read/34539774/measuring-synchronization-between-spikes-and-local-field-potential-based-on-the-kullback-leibler-divergence
#39
JOURNAL ARTICLE
Liyong Yin, Guangrong Zhang, Fuzai Yin
Neurophysiological studies have shown that there is a close relationship between spikes and local field potential (LFP), which reflects crucial neural coding information. In this paper, we used a new method to evaluate the synchronization between spikes and LFP. All possible phases of LFP from - π to π were first binned into a freely chosen number of bins; then, the probability of spikes falling in each bin was calculated, and the deviation degree from the uniform distribution based on the Kullback-Leibler divergence was calculated to define the synchronization between spikes and LFP...
2021: Computational Intelligence and Neuroscience
https://read.qxmd.com/read/34486376/the-relationship-between-the-rhythmic-components-of-the-brain-electrical-activity-during-the-development-of-status-epilepticus-an-operational-model-of-brain-rhythms-generation
#40
JOURNAL ARTICLE
Alexandr Bondar, Liubov Shubina
Introduction: Despite the fact that brain rhythms are widely studied and officially classified, there is no consensus on their relationship, which can shed light on the genesis of rhythmic activity, its synchronization, functional role, and the formation of pathological reactions. Using the experimental status epilepticus (SE) as a model of brain in a hypersynchronized state with well-defined rhythms, we aimed to study the relationship between the rhythmic components of the brain electrical activity. Materials and Methods: Local field potentials (LFPs) were recorded simultaneously from the hippocampus, entorhinal cortex, medial septum, and amygdala during normal conditions and after kainic acid (KA) administration in waking guinea pigs...
August 2022: Brain Connectivity
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