Vahid Ahli Khatibi, Morteza Salimi, Mona Rahdar, Mahmoud Rezaei, Milad Nazari, Samaneh Dehghan, Shima Davoudi, Mohammad Reza Raoufy, Javad Mirnajafi-Zadeh, Mohammad Javan, Narges Hosseinmardi, Gila Behzadi, Mahyar Janahmadi
Pharmacoresistant temporal lobe epilepsy affects millions of people around the world with uncontrolled seizures and comorbidities, like anxiety, being the most problematic aspects calling for novel therapies. The intrahippocampal kainic acid model of temporal lobe epilepsy is an appropriate rodent model to evaluate the effects of novel interventions, including glycolysis inhibition, on epilepsy-induced alterations. Here, we investigated kainic acid-induced changes in the dorsal hippocampus (dHPC) and basolateral amygdala (BLA) circuit and the efficiency of a glycolysis inhibitor, 2-deoxy D-glucose (2-DG), in resetting such alterations using simultaneous local field potentials (LFP) recording and elevated zero-maze test...
April 21, 2023: Scientific Reports