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https://www.readbyqxmd.com/read/28431279/cognitive-control-in-action-tracking-the-dynamics-of-rule-switching-in-5-to-8-year-olds-and-adults
#1
Christopher D Erb, Jeff Moher, Joo-Hyun Song, David M Sobel
Recent studies have suggested that dissociable processes featuring distinct types of inhibition support cognitive control in tasks requiring participants to override a prepotent response with a control-demanding alternative response. An open question concerns how these processes support cognitive flexibility in rule-switching tasks. We used a technique known as reach tracking to investigate how 5- to 8-year-olds (Experiment 1) and adults (Experiment 2) select, maintain, and switch between incompatible rule sets in a computerized version of the Dimensional Change Card Sort (DCCS)...
April 17, 2017: Cognition
https://www.readbyqxmd.com/read/28422721/functional-analysis-implicating-the-snp-rs61552325-in-erbb2-as-an-effector-for-androgen-insensitive-prostate-cancer-cell-invasion
#2
Xianxiang Xin, Yinmin Gu, Yang Chen, Yuanjie Huang, Zengnan Mo, Yanling Hu
BACKGROUND: As one of the most common cancers in men, the pathogenesis of prostate cancer has been widely researched. Aberrant activation of the erb-b2 receptor tyrosine kinase 2 (ERBB2) has been found to play a critical role in metastatic prostate cancer. In our previous study, we demonstrated that rs61552325 (Pro1140Ala) located in ERBB2 is strongly correlated to prostate cancer. Therefore, we initially studied the effect of rs61552325 on androgen-independent prostate cancer cell metastasis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408484/joint-features-and-complementarities-of-tspan8-and-cd151-revealed-in-knockdown-and-knockout-models
#3
REVIEW
Shijing Yue, Kun Zhao, Ulrike Erb, Sanyukta Rana, Margot Zöller
Tetraspanins are highly conserved 4-transmembrane proteins which form molecular clusters with a large variety of transmembrane and cytosolic proteins. By these associations tetraspanins are engaged in a multitude of biological processes. Furthermore, tetraspanin complexes are located in specialized microdomains, called tetraspanin-enriched microdomains (TEMs). TEMs provide a signaling platform and are poised for invagination and vesicle formation. These vesicles can be released as exosomes (Exo) and are important in cell contact-independent intercellular communication...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28407345/dosimetric-impacts-of-endorectal-balloon-in-cyberknife-stereotactic-body-radiation-therapy-sbrt-for-early-stage-prostate-cancer
#4
Hong F Xiang, Hsiao-Ming Lu, Jason A Efstathiou, Anthony L Zietman, Ricardo De Armas, Kathryn Harris, B Nicolas Bloch, Muhammad Mustafa Qureshi, Sean Keohan, Ariel E Hirsch
PURPOSE: In SBRT for prostate cancer, higher fractional dose to the rectum is a major toxicity concern due to using smaller PTV margin and hypofractionation. We investigate the dosimetric impact on rectum using endorectal balloon (ERB) in prostate SBRT. MATERIALS AND METHODS: Twenty prostate cancer patients were included in a retrospective study, ten with ERB and 10 without ERB. Optimized SBRT plans were generated on CyberKnife MultiPlan for 5 × 7.25 Gy to PTV under RTOG-0938 protocol for early-stage prostate cancer...
April 13, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28406343/insights-from-native-mass-spectrometry-approaches-for-top-and-middle-level-characterization-of-site-specific-antibody-drug-conjugates
#5
Thomas Botzanowski, Stéphane Erb, Oscar Hernandez-Alba, Anthony Ehkirch, Olivier Colas, Elsa Wagner-Rousset, David Rabuka, Alain Beck, Penelope M Drake, Sarah Cianferani
Antibody-drug conjugates (ADCs) have emerged as a family of compounds with promise as efficient immunotherapies. First-generation ADCs were generated mostly via reactions on either lysine side-chain amines or cysteine thiol groups after reduction of the interchain disulfide bonds, resulting in heterogeneous populations with a variable number of drug loads per antibody. In order to control the position and the number of drug loads, new conjugation strategies aiming at the generation of more homogeneous site-specific conjugates have been developed...
April 13, 2017: MAbs
https://www.readbyqxmd.com/read/28402449/enhancement-of-trophoblast-differentiation-and-survival-by-low-molecular-weight-heparin-requires-heparin-binding-egf-like-growth-factor
#6
Alan D Bolnick, Jay M Bolnick, Hamid-Reza Kohan-Ghadr, Brian A Kilburn, Omar J Pasalodos, Pankaj K Singhal, Jing Dai, Michael P Diamond, D Randall Armant, Sascha Drewlo
STUDY QUESTION: Does low molecular weight heparin (LMWH) require heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) signaling to induce extravillous trophoblast differentiation and decrease apoptosis during oxidative stress? SUMMARY ANSWER: LMWH increased HBEGF expression and secretion, and HBEGF signaling was required to stimulate trophoblast extravillous differentiation, increase invasion in vitro and reduce trophoblast apoptosis during oxidative stress...
April 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28397460/is-there-a-genotoxic-potential-of-endodontic-root-materials
#7
Andreas Taubmann, Brita Willershausen, Christina Erbe, Bernd Kaina, Ines Willershausen
BACKGROUND: Leakage of components from endodontic materials (EM) can occur in case of apical extrusion into the periapical tissue. Therefore, an important prerequisite, besides the mechanical properties of the EM, is a high biocompatibility. In the present study, we elucidated the genotoxic potential of EMs of different base composition by utilizing the -H2AX assay. METHODS: For investigation of the genotoxic potential of EM, supernatants of commercially available EM were prepared and dilutions were applied to human gingival fibroblasts...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28387865/strengthening-hiv-therapy-and-care-in-rural-tanzania-affects-rates-of-viral-suppression
#8
Alex J Ntamatungiro, Lukas Muri, Tracy R Glass, Stefan Erb, Manuel Battegay, Hansjakob Furrer, Christoph Hatz, Marcel Tanner, Ingrid Felger, Thomas Klimkait, Emilio Letang
Objectives: To assess viral suppression rates, to assess prevalence of acquired HIV drug resistance and to characterize the spectrum of HIV-1 drug resistance mutations (HIV-DRM) in HIV-1-infected patients in a rural Tanzanian HIV cohort. Methods: This was a cross-sectional study nested within the Kilombero and Ulanga Antiretroviral Cohort. Virological failure was defined as HIV-1 RNA ≥50 copies/mL. Risk factors associated with virological failure and with the development of HIV-DRM were assessed using logistic regression...
April 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28387663/quantitative-parameters-of-contrast-enhanced-ultrasound-in-breast-invasive-ductal-carcinoma-the-correlation-with-pathological-prognostic-factors
#9
Chen-Li Ji, Xiao-Long Li, Ya-Ping He, Dan-Dan Li, Xin-Gang Gu, Hui-Xiong Xu
PURPOSE: To investigate the correlation between quantitative parameters on contrast-enhanced ultrasound (CEUS) and pathological prognostic factors in patients with breast invasive ductal carcinomas (IDCs). MATERIALS AND METHODS: 102 patients with pathologically proven IDCs were retrospectively enrolled and all were preoperatively evaluated by CEUS. Quantitative analysis was conducted using the SonoLiver® software. On the parametric imaging, the data of rise time (RT), time to peak (TTP), mean transit time (mTT) and maximum intensity (IMAX) were recorded...
April 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28382017/disrupted-ultradian-activity-rhythms-and-differential-expression-of-several-clock-genes-in-interleukin-6-deficient-mice
#10
Francisco J Monje, Ana Cicvaric, Juan Pablo Acevedo Aguilar, Immanuel Elbau, Orsolya Horvath, Weifei Diao, Micaela Glat, Daniela D Pollak
The characteristics of the cycles of activity and rest stand out among the most intensively investigated aspects of circadian rhythmicity in humans and experimental animals. Alterations in the circadian patterns of activity and rest are strongly linked to cognitive and emotional dysfunctions in severe mental illnesses such as Alzheimer's disease (AD) and major depression (MDD). The proinflammatory cytokine interleukin 6 (IL-6) has been prominently associated with the pathogenesis of AD and MDD. However, the potential involvement of IL-6 in the modulation of the diurnal rhythms of activity and rest has not been investigated...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28381310/biochemical-histopathologic-physiologic-and-behavioral-effects-of-nonsteroidal-antiinflammatory-drugs-in-rainbow-trout-oncorhynchus-mykiss
#11
Amy L Rizzo, Gregory A Wooster, Luce E Guanzini, Christine M Peterson, Karryssas Fenderson, Hollis N Erb, Paul R Bowser, Mary E Martin
Because the number of fish being used in research is increasing rapidly, evaluating the analgesic and pathologic effects of NSAID in fish is essential. To determine the biochemical, histopathologic, physiologic and behavioral effects of 3 NSAID, 48 rainbow trout underwent anesthesia with tricaine methanesulfonate and exploratory celiotomy and were randomly assigned to receive flunixin (0.5 mg/kg IM), ketorolac (0.5 mg/kg IM), ketoprofen (2 mg/kg IM), or saline. Clinical pathologic variables were assessed 1 wk before surgery and 48 h after surgery...
March 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28370878/biomass-responses-in-a-temperate-european-grassland-through-17-years-of-elevated-co2
#12
L C Andresen, N Yuan, R Seibert, G Moser, C I Kammann, J Luterbacher, M Erbs, C Müller
Future increase of atmospheric CO2 concentrations will potentially enhance grassland biomass production and shift the functional group composition with consequences for ecosystem functioning. In the 'GiFACE' experiment (Giessen Free Air Carbon dioxide Enrichment), fertilized grassland plots were fumigated with elevated CO2 (eCO2 ) year-round during daylight hours since 1998, at a level of +20% relative to ambient concentrations (in 1998 aCO2 was 364 ppm and eCO2 399 ppm; in 2014 aCO2 was 397 ppm and eCO2 518 ppm)...
April 2, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28363037/the-passage-and-duration-of-antibodies-to-west-nile-virus-in-humboldt-penguins-spheniscus-humboldti
#13
Andrew C Cushing, Edward Dubovi, Hollis N Erb, Timothy A Georoff, Noha Abou-Madi
West Nile virus (genus Flavivirus) outbreaks and mortality events have been documented in both wild and captive avian species, including penguins. Serologic response to vaccination in avian species has varied and appears to be largely species dependent; however, Humboldt penguins ( Spheniscus humboldti ) previously showed excellent rates of seroconversion. The goal of this study was to determine virus neutralization titers of 17 Humboldt penguin hens and their subsequent eggs, chicks, or both following vaccination with a killed West Nile vaccine...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28359215/comorbidities-might-condition-the-recovery-of-quality-of-life-in-survivors-of-sepsis
#14
Gislene C Erbs, Marco F Mastroeni, Mauro S L Pinho, Álvaro Koenig, Geonice Sperotto, John Paul Ekwaru, Glauco A Westphal
PURPOSE: To assess how preexisting disabling comorbidities (DC) affect the recovery rate of quality of life (QOL) over time in sepsis survivors. METHODS: A prospective study was conducted on sepsis survivors who answered the 36-Item Short Form Health Survey (SF-36) 7 days after discharge from the intensive care unit. Subsequent interviews were held at 3, 6, and 12 months. The results of the physical component score (PCS) and mental component score (MCS) of the SF-36 were evaluated...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28356939/identification-of-genes-associated-with-tongue-cancer-in-patients-with-a-history-of-tobacco-and-or-alcohol-use
#15
Yin Zhao, Dongna Fu, Chengbi Xu, Jingpu Yang, Zonggui Wang
The present study aimed to identify genes associated with tongue cancer in patients with a history of tobacco and/or alcohol use. Microarray dataset GSE42023, including 10 tissue samples of tongue cancer from patients with a history of tobacco and/or alcohol use (habit group) and 11 tissue samples of non-habit-associated tongue cancer (non-habit group), were downloaded from the Gene Expression Omnibus database. Differentially-expressed genes (DEGs) between the habit and non-habit groups were identified using the Linear Models for Microarray Data software package...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28356710/switching-to-preservative-free-latanoprost-impact-on-tolerability-and-patient-satisfaction
#16
Francisco José Muñoz Negrete, Hans G Lemij, Carl Erb
Patient satisfaction with glaucoma treatment has been poorly studied to date. Because glaucoma is a chronic condition in which the therapeutic response is dependent on adherence to treatment, patient acceptability is an important factor in achieving satisfactory outcomes. This multicenter, international (Belgium, the Netherlands, and Spain), epidemiological convenience sample survey among patients commencing treatment with preservative-free latanoprost collected data on patient satisfaction with particular regard to tolerability...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28355873/role-of-vacancy-condensation-in-the-formation-of-voids-in-rutile-tio2-nanowires
#17
Alena Folger, Petra Ebbinghaus, Andreas Erbe, Christina Scheu
Titanium dioxide nanowire (NW) arrays are incorporated in many devices for energy conversion, energy storage, and catalysis. A common approach to fabricate these NWs is based on hydrothermal synthesis strategies. A drawback of this low-temperature method is that the NWs have a high density of defects, such as stacking faults, dislocations, and oxygen vacancies. These defects compromise the performance of devices. Here, we report a postgrowth thermal annealing procedure to remove these lattice defects and propose a mechanism to explain the underlying changes in the structure of the NWs...
April 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28353119/safety-and-feasibility-of-pleural-cryobiopsy-compared-to-forceps-biopsy-during-semi-rigid-pleuroscopy
#18
Vikas Pathak, Ray W Shepherd, Ehab Hussein, Rajiv Malhotra
BACKGROUND: Pleural biopsy is often obtained in patients with undiagnosed exudative pleural effusion during pleuroscopy. Standard forceps have been traditionally used for the biopsy. Cryoprobes are being increasingly used for transbronchial lung biopsy as they obtain larger specimens and have less crush artifact. However, the safety and feasibility of cryoprobe biopsy compared to standard forceps for pleural biopsy has not been fully assessed. OBJECTIVES: The objective of this study was to demonstrate the safety and feasibility of cryoprobe biopsy in the pleural space using semi-rigid pleuroscopy...
March 28, 2017: Lung
https://www.readbyqxmd.com/read/28350117/reduced-expression-of-mir%C3%A2-205%C3%A2-5p-promotes-apoptosis-and-inhibits-proliferation-and-invasion-in-lung-cancer-a549-cells-by-upregulation-of-zeb2-and-downregulation-of-erbb3
#19
Min Jiang, Ting Zhong, Wei Zhang, Zuke Xiao, Guozhu Hu, Hong Zhou, Haibin Kuang
Previous studies have demonstrated that microRNA (miR)-205-5p expression is significantly increased in non‑small cell lung cancer tissues and is associated with tumor differentiation grade. The aim of the present study was to explore the effects of miR‑205‑5p on viability, apoptosis and invasion of lung cancer A549 cells. The hsa‑miR‑205‑5p small interfering RNA (siRNA) inhibitor was transfected into A549 cells and expression of miR‑205‑5p was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR)...
March 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28345163/pharmacokinetics-and-safety-of-letermovir-a-novel-anti-human-cytomegalovirus-drug-in-patients-with-renal-impairment
#20
D Kropeit, J Scheuenpflug, K Erb-Zohar, A Halabi, H-P Stobernack, E G J Hulskotte, A van Schanke, H Zimmermann, H Rübsamen-Schaeff
AIMS: Human cytomegalovirus remains a significant issue for immunocompromised patients and existing viral polymerase targeting therapies are associated with significant toxicity. Accordingly, the viral terminase complex inhibitor, letermovir, is in development. We assessed letermovir pharmacokinetics in renal impairment. METHODS: This was a Phase 1, open-label, non-randomised trial. Estimated glomerular filtration rate (eGFR) based on the Modification of Diet Renal Disease equation was used to create 3 groups of 8 subjects: healthy function (eGFR ≥90 mL/min/1...
March 26, 2017: British Journal of Clinical Pharmacology
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