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https://www.readbyqxmd.com/read/28226387/-general-effects-on-glaucoma
#1
Carl Erb
No abstract text is available yet for this article.
February 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28223222/disrupting-the-key-circadian-regulator-clock-leads-to-age-dependent-cardiovascular-disease
#2
Faisal J Alibhai, Jonathan LaMarre, Cristine J Reitz, Elena V Tsimakouridze, Jeffrey T Kroetsch, Steffen-Sebastian Bolz, Alex Shulman, Samantha Steinberg, Thomas P Burris, Gavin Y Oudit, Tami A Martino
The circadian mechanism underlies daily rhythms in cardiovascular physiology and rhythm disruption is a major risk factor for heart disease and worse outcomes. However, the role of circadian rhythms is generally clinically unappreciated. Clock is a core component of the circadian mechanism and here we examine the role of Clock as a vital determinant of cardiac physiology and pathophysiology in aging. Clock(Δ19/Δ19) mice develop age-dependent increases in heart weight, hypertrophy, dilation, impaired contractility, and reduced myogenic responsiveness...
February 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28221964/methods-and-processes-of-developing-the-strengthening-the-reporting-of-observational-studies-in-epidemiology-veterinary-strobe-vet-statement
#3
J M Sargeant, A M O'Connor, I R Dohoo, H N Erb, M Cevallos, M Egger, A K Ersbøll, S W Martin, L R Nielsen, D L Pearl, D U Pfeiffer, J Sanchez, M E Torrence, H Vigre, C Waldner, M P Ward
Reporting of observational studies in veterinary research presents challenges that often are not addressed in published reporting guidelines. Our objective was to develop an extension of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement that addresses unique reporting requirements for observational studies in veterinary medicine related to health, production, welfare, and food safety. We conducted a consensus meeting with 17 experts in Mississauga, Canada. Experts completed a premeeting survey about whether items in the STROBE statement should be modified or added to address unique issues related to observational studies in animal species with health, production, welfare, or food safety outcomes...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28220204/-urofors-establishment-of-an-interest-group-for-natural-scientists-in-urological-research
#4
M B Stope, T Dansranjavin, H Erb, K Erdmann, A Fendler, S Hölters, E Jüngel, K Nitschke, K Salomo, P Seidel, M A Skowron, S Wach, C Becker
No abstract text is available yet for this article.
February 20, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28218603/frequency-and-clinical-course-of-cerebral-embolism-in-patients-undergoing-transcatheter-left-atrial-appendage-closure
#5
Nicolas Majunke, Franziska Eplinius, Matthias Gutberlet, Sven Moebius-Winkler, Ingo Daehnert, Matthias Grothoff, Stephan Schürer, Norman Mangner, Philipp Lurz, Sandra Erbs, Katharina Kirsch, Gerhard Schuler, Marcus Sandri
AIMS: To assess silent and clinically apparent cerebral embolic events in patients undergoing transcatheter left atrial appendage closure. METHODS AND RESULTS: In this prospective single-center study 28 patients underwent percutaneous closure of the left atrial appendage. In all patients a diffusion-weighted magnetic resonance imaging (DWI-MRI) study was performed before, the day after the procedure and during routine follow-up after 45 days. All patients underwent neurological assessment at the time of DWI-MRI...
February 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28213272/rev-erb-regulation-of-cholesterologenesis
#6
Sadichha Sitaula, Jinsong Zhang, Fernanda Ruiz, Thomas P Burris
REV-ERBα and REV-ERBβ are heme regulated nuclear receptors that are known to regulate metabolic pathways. We previously demonstrated that treatment of mice with synthetic REV-ERB agonists suppressed plasma cholesterol levels and the hepatic levels of the rate limiting enzyme in cholesterol biosynthesis (3-hydroxy-3-Mmethylglutaryl-CoA reductase). Here, we characterize the role of REV-ERB on the cholesterol biosynthetic pathway in greater detail. The REV-ERB agonist SR9009 reduced plasma cholesterol levels in both wild type C57Bl/6 and low density lipoprotein receptor (LDLR) null mice as well as reducing the expression of an array of genes within the cholesterol biosynthetic pathway...
February 14, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28202954/in-vitro-characterization-and-concerted-function-of-three-core-enzymes-of-a-glycyl-radical-enzyme-associated-bacterial-microcompartment
#7
Jan Zarzycki, Markus Sutter, Niña Socorro Cortina, Tobias J Erb, Cheryl A Kerfeld
Many bacteria encode proteinaceous bacterial microcompartments (BMCs) that encapsulate sequential enzymatic reactions of diverse metabolic pathways. Well-characterized BMCs include carboxysomes for CO2-fixation, and propanediol- and ethanolamine-utilizing microcompartments that contain B12-dependent enzymes. Genes required to form BMCs are typically organized in gene clusters, which promoted their distribution across phyla by horizontal gene transfer. Recently, BMCs associated with glycyl radical enzymes (GREs) were discovered; these are widespread and comprise at least three functionally distinct types...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28199041/feasibility-of-accelerated-simultaneous-multislice-diffusion-weighted-mri-of-the-prostate
#8
Jakob Weiss, Petros Martirosian, Jana Taron, Ahmed E Othman, Thomas Kuestner, Michael Erb, Jens Bedke, Fabian Bamberg, Konstantin Nikolaou, Mike Notohamiprodjo
PURPOSE: To assess the feasibility of simultaneous multislice (SMS) single-shot echo-planar-imaging (EPI) for accelerated diffusion-weighted imaging (DWI) of the prostate. MATERIALS AND METHODS: For phantom measurements a dedicated DWI phantom with different sucrose concentrations was used. In addition, 10 volunteers and 16 patients with suspected prostate cancer were examined for in vivo measurements. All examinations were performed with a 3T magnetic resonance imaging (MRI) system...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28196961/bacterial-topography-of-the-healthy-human-lower-respiratory-tract
#9
Robert P Dickson, John R Erb-Downward, Christine M Freeman, Lisa McCloskey, Nicole R Falkowski, Gary B Huffnagle, Jeffrey L Curtis
Although culture-independent techniques have refuted lung sterility in health, controversy about contamination during bronchoscope passage through the upper respiratory tract (URT) has impeded research progress. We sought to establish whether bronchoscopic sampling accurately reflects the lung microbiome in health and to distinguish between two proposed routes of authentic microbial immigration, (i) dispersion along contiguous respiratory mucosa and (ii) subclinical microaspiration. During bronchoscopy of eight adult volunteers without lung disease, we performed seven protected specimen brushings (PSB) and bilateral bronchoalveolar lavages (BALs) per subject...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28194016/modelling-filovirus-maintenance-in-nature-by-experimental-transmission-of-marburg-virus-between-egyptian-rousette-bats
#10
Amy J Schuh, Brian R Amman, Megan E B Jones, Tara K Sealy, Luke S Uebelhoer, Jessica R Spengler, Brock E Martin, Jo Ann D Coleman-McCray, Stuart T Nichol, Jonathan S Towner
The Egyptian rousette bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which MARV is transmitted bat-to-bat and to other animals are unclear. Here we co-house MARV-inoculated donor ERBs with naive contact ERBs. MARV shedding is detected in oral, rectal and urine specimens from inoculated bats from 5-19 days post infection. Simultaneously, MARV is detected in oral specimens from contact bats, indicating oral exposure to the virus. In the late study phase, we provide evidence that MARV can be horizontally transmitted from inoculated to contact ERBs by finding MARV RNA in blood and oral specimens from contact bats, followed by MARV IgG antibodies in these same bats...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28193263/automated-freeze-thaw-cycles-for-decellularization-of-tendon-tissue-a-pilot-study
#11
Susanne Pauline Roth, Sina Marie Glauche, Amelie Plenge, Ina Erbe, Sandra Heller, Janina Burk
BACKGROUND: Decellularization of tendon tissue plays a pivotal role in current tissue engineering approaches for in vitro research as well as for translation of graft-based tendon restoration into clinics. Automation of essential decellularization steps like freeze-thawing is crucial for the development of more standardized decellularization protocols and commercial graft production under good manufacturing practice (GMP) conditions in the future. METHODS: In this study, a liquid nitrogen-based controlled rate freezer was utilized for automation of repeated freeze-thawing for decellularization of equine superficial digital flexor tendons...
February 14, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28192048/a-serosurvey-of-diseases-of-free-ranging-gray-wolves-canis-lupus-in-minnesota
#12
Michelle Carstensen, John H Giudice, Erik C Hildebrand, J P Dubey, John Erb, Dan Stark, John Hart, Shannon Barber-Meyer, L David Mech, Steve K Windels, Andrew J Edwards
We tested serum samples from 387 free-ranging wolves ( Canis lupus ) from 2007 to 2013 for exposure to eight canid pathogens to establish baseline data on disease prevalence and spatial distribution in Minnesota's wolf population. We found high exposure to canine adenoviruses 1 and 2 (88% adults, 45% pups), canine parvovirus (82% adults, 24% pups), and Lyme disease (76% adults, 39% pups). Sixty-six percent of adults and 36% of pups exhibited exposure to the protozoan parasite Neospora caninum . Exposure to arboviruses was confirmed, including West Nile virus (37% adults, 18% pups) and eastern equine encephalitis (3% adults)...
February 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28190797/endothelial-function-in-children-and-adolescents-is-mainly-influenced-by-age-sex-and-physical-activity%C3%A3-an-analysis-of-reactive-hyperemic-peripheral-artery-tonometry
#13
Ulrike M Mueller, Claudia Walther, Jennifer Adam, Kati Fikenzer, Sandra Erbs, Meinhard Mende, Volker Adams, Axel Linke, Gerhard Schuler
BACKGROUND: As adolescents rarely experience cardiovascular events, surrogate markers of atherosclerosis are useful to justify and monitor effects of primary prevention and therapy of risk factors. Endothelial function assessed by reactive hyperemic peripheral arterial tonometry (RH-PAT) resulting in a reactive hyperemic index (RHI) is a noninvasive method with limited data for use in children and adolescents.Methods and Results:We performed a total of 931 RHI measurements in 445 high-school students, aged 10-17 years, over a time period of 5 years...
February 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28181336/impact-of-high-concentrations-of-sevoflurane-on-laryngeal-reflex-responses
#14
Thomas O Erb, Britta S von Ungern-Sternberg, Jens Moll, Franz J Frei
BACKGROUND: Exaggerated defensive upper airway reflexes, particularly laryngospasm, may cause hypoxemic damage, especially in children. General clinical experience suggests that laryngeal reflex responses are more common under light levels of anesthesia, and previous clinical studies have shown an inverse correlation between laryngeal responsiveness and depth of hypnosis. However, this seems to be less obvious in children anesthetized with sevoflurane. The aim of this study was to assess the impact of high concentrations of sevoflurane on laryngeal and respiratory reflex responses in spontaneously breathing children...
February 8, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28180076/face-name-association-task-reveals-memory-networks-in-patients-with-left-and-right-hippocampal-sclerosis
#15
Silke Klamer, Monika Milian, Michael Erb, Sabine Rona, Holger Lerche, Thomas Ethofer
We aimed to identify reorganization processes of episodic memory networks in patients with left and right temporal lobe epilepsy (TLE) due to hippocampal sclerosis as well as their relations to neuropsychological memory performance. We investigated 28 healthy subjects, 12 patients with left TLE (LTLE) and 9 patients with right TLE (RTLE) with hippocampal sclerosis by means of functional magnetic resonance imaging (fMRI) using a face-name association task, which combines verbal and non-verbal memory functions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28178722/differential-gene-expression-in-ductal-carcinoma-in-situ-of-the-breast-based-on-erbb2-status
#16
Emmanuel Agosto-Arroyo, Tatyana Isayeva, Shi Wei, Jonas S Almeida, Shuko Harada
BACKGROUND: The molecular signature of ductal carcinoma in situ (DCIS) in the breast is not well understood. Erb-b2 receptor tyrosine kinase 2 (ERBB2 [formerly known as HER2/neu]) positivity in DCIS is predictive of coexistent early invasive breast carcinoma. The aim of this study is to identify the gene-expression signature profiles of estrogen receptor (ER)/progesterone receptor (PR)-positive, ERBB2, and triple-negative subtypes of DCIS. METHODS: Based on ER, PR, and ERBB2 status, a total of 18 high nuclear grade DCIS cases with no evidence of invasive breast carcinoma were selected along with 6 non-neoplastic controls...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28178720/erbb4-expression-in-ovarian-serous-carcinoma-resistant-to-platinum-based-therapy
#17
COMPARATIVE STUDY
Ozlen Saglam, Yin Xiong, Douglas C Marchion, Carolina Strosberg, Robert M Wenham, Joseph J Johnson, Daryoush Saeed-Vafa, Christopher Cubitt, Ardeshir Hakam, Anthony M Magliocco
Few data exist on the prognostic and predictive impact of erb-b2 receptor tyrosine kinase 4 (ERBB4) in ovarian cancer. Thus, we evaluated ERBB4 expression by immunohistochemistry in a tumor microarray consisting of 100 ovarian serous carcinoma specimens (50 complete responses [CRs] and 50 incomplete responses [IRs] to platinum-based therapy), 51 normal tissue controls, and 16 ovarian cancer cell lines. H scores were used to evaluate expression and were semiquantitatively classified into low, intermediate, and high categories...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28177438/vectorized-gene-therapy-of-liver-tumors-proof-of-concept-of-tg4023-mva-fcu1-in-combination-with-flucytosine
#18
F Husseini, J-P Delord, C Fournel-Federico, J Guitton, P Erbs, M Homerin, C Halluard, C Jemming, C Orange, J-M Limacher, J-E Kurtz
No abstract text is available yet for this article.
January 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28175940/-avoidance-of-complications-when-dealing-with-central-venous-catheters-in-the-treatment-of-children
#19
D Aprili, T O Erb
Central venous catheters (CVCs) are an important tool in the treatment of children. The insertion of a catheter may result in different complications depending of the type of catheter, the technique used for the insertion and the location. There are various techniques to reduce the risk of complications. In order to reduce the rate of complications of CVCs it is indispensable to perform a risk-benefit analysis for the individual patient before every insertion. The type of catheter used (for example tunneled catheters versus not-tunneled catheters) influences the rate of catheter-associated infections and the comfort of the patient significantly...
February 7, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28172613/transmissibility-of-clostridium-difficile-without-contact-isolation-results-from-a-prospective-observational-study-with-451-patients
#20
Andreas F Widmer, Reno Frei, Stefan Erb, Anne Stranden, Ed J Kuijper, Cornelis W Knetsch, Sarah Tschudin-Sutter
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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