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https://www.readbyqxmd.com/read/28924734/evaluation-of-a-novel-electrosurgical-sealing-mode-in-an-ex-vivo-and-in-vivo-porcine-model
#1
Karolin Thiel, Walter Linzenbold, Markus D Enderle, B Nold, Alfred Königsrainer, Martin Schenk, Christian Thiel
BACKGROUND: Bipolar vessel sealing has been successfully introduced in a variety of procedures like prostatectomy, hysterectomy, and nephrectomy. In this study, we evaluated a new sealing mode-the thermoSEAL(®) mode (TSM)-operated with the VIO3 generator in an ex vivo and in vivo animal study and compared the results with the commercially available BiClamp mode (BCM), operated with the VIO300D generator. Two different instruments were used in combination with both modes, BiCision(®) and BiClamp(®) 201T (Erbe Elektromedizin GmbH)...
September 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28919702/micro-invasive-glaucoma-surgery-migs-a-review-of-surgical-procedures-using-stents
#2
Lutz E Pillunat, Carl Erb, Anselm Gm Jünemann, Friedemann Kimmich
Over the last decade several novel surgical treatment options and devices for glaucoma have been developed. All these developments aim to cause as little trauma as possible to the eye, to safely, effectively, and sustainably reduce intraocular pressure (IOP), to produce reproducible results, and to be easy to adopt. The term "micro-invasive glaucoma surgery (MIGS)" was used for summarizing all these procedures. Currently MIGS is gaining more and more interest and popularity. The possible reduction of the number of glaucoma medications, the ab interno approach without damaging the conjunctival tissue, and the probably safer procedures compared to incisional surgical methods may explain the increased interest in MIGS...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28916506/blending-face-to-face-and-internet-based-interventions-for-the-treatment-of-mental-disorders-in-adults-systematic-review
#3
Doris Erbe, Hans-Christoph Eichert, Heleen Riper, David Daniel Ebert
BACKGROUND: Many studies have provided evidence for the effectiveness of Internet-based stand-alone interventions for mental disorders. A newer form of intervention combines the strengths of face-to-face (f2f) and Internet approaches (blended interventions). OBJECTIVE: The aim of this review was to provide an overview of (1) the different formats of blended treatments for adults, (2) the stage of treatment in which these are applied, (3) their objective in combining face-to-face and Internet-based approaches, and (4) their effectiveness...
September 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28916248/breast-cancer-vaccines-delivered-by-dendritic-cell-targeted-lentivectors-induce-potent-antitumor-immune-responses-and-protect-mice-from-mammary-tumor-growth
#4
Paul D Bryson, Xiaolu Han, Norman Truong, Pin Wang
Breast cancer immunotherapy is a potent treatment option, with antibody therapies such as trastuzumab increasing 2-year survival rates by 50%. However, active immunotherapy through vaccination has generally been clinically ineffective. One potential means of improving vaccine therapy is by delivering breast cancer antigens to dendritic cells (DCs) for enhanced antigen presentation. To accomplish this in vivo, we pseudotyped lentiviral vector (LV) vaccines with a modified Sindbis Virus glycoprotein so that they could deliver genes encoding the breast cancer antigen alpha-lactalbumin (Lalba) or erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2) directly to resident DCs...
September 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28913882/reducing-disparities-in-cancer-screening-and-prevention-through-community-based-participatory-research-partnerships-with-local-libraries-a-comprehensive-dynamic-trial
#5
Bruce D Rapkin, Elisa Weiss, David Lounsbury, Tamara Michel, Alexis Gordon, Jennifer Erb-Downward, Eilleen Sabino-Laughlin, Alison Carpenter, Carolyn E Schwartz, Linda Bulone, Margaret Kemeny
Reduction of cancer-related disparities requires strategies that link medically underserved communities to preventive care. In this community-based participatory research project, a public library system brought together stakeholders to plan and undertake programs to address cancer screening and risk behavior. This study was implemented over 48 months in 20 large urban neighborhoods, selected to reach diverse communities disconnected from care. In each neighborhood, Cancer Action Councils were organized to conduct a comprehensive dynamic trial, an iterative process of program planning, implementation and evaluation...
September 15, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28895948/underwater-recordings-of-the-whistles-of-bottlenose-dolphins-in-fremantle-inner-harbour-western-australia
#6
Sarah A Marley, Christine Erbe, Chandra P Salgado Kent
Dolphins use frequency-modulated whistles for a variety of social functions. Whistles vary in their characteristics according to context, such as activity state, group size, group composition, geographic location, and ambient noise levels. Therefore, comparison of whistle characteristics can be used to address numerous research questions regarding dolphin populations and behaviour. However, logistical and economic constraints on dolphin research have resulted in data collection biases, inconsistent analytical approaches, and knowledge gaps...
September 12, 2017: Scientific Data
https://www.readbyqxmd.com/read/28893414/transcriptional-mediated-effects-of-radiation-on-the-expression-of-immune-susceptibility-markers-in-melanoma
#7
Lauryn R Werner, Jasdeep S Kler, Monica M Gressett, Maureen Riegert, Lindsey K Werner, Clinton M Heinze, Joseph G Kern, Mahyar Abbariki, Amy K Erbe, Ravi B Patel, Raghava N Sriramaneni, Paul M Harari, Zachary S Morris
BACKGROUND AND PURPOSE: We recently reported a time-sensitive, cooperative, anti-tumor effect elicited by radiation (RT) and intra-tumoral-immunocytokine injection in vivo. We hypothesized that RT triggers transcriptional-mediated changes in tumor expression of immune susceptibility markers at delayed time points, which may explain these previously observed time-dependent effects. MATERIALS AND METHODS: We examined the time course of changes in expression of immune susceptibility markers following in vitro or in vivo RT in B78 murine melanoma and A375 human melanoma using flow cytometry, immunoblotting, and qPCR...
September 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28893156/erythrosine-b-and-quinoline-yellow-dyes-regulate-dna-repair-gene-expression-in-human-hepg2-cells
#8
Farah Md Chequer, Vinicius P Venancio, Mara R Almeida, Alexandre F Aissa, Maria Lourdes P Bianchi, Lusânia Mg Antunes
Erythrosine B (ErB) is a cherry pink food colorant and is widely used in foods, drugs, and cosmetics. Quinoline yellow (QY) is a chinophthalon derivative used in cosmetic compositions for application to the skin, lips, and/or body surface. Previously, ErB and QY synthetic dyes were found to induce DNA damage in HepG2 cells. The aim of this study was to investigate the molecular basis underlying the genotoxicity attributed to ErB and QY using the RT(2) Profiler polymerase chain reaction array and by analyzing the expression profile of 84 genes involved in cell cycle arrest, apoptosis, and DNA repair in HepG2 cells...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28878135/rev-erb%C3%AE-ameliorates-heart-failure-through-transcription-repression
#9
Lilei Zhang, Rongli Zhang, Chih-Liang Tien, Ricky E Chan, Keiki Sugi, Chen Fu, Austin C Griffin, Yuyan Shen, Thomas P Burris, Xudong Liao, Mukesh K Jain
A cure for heart failure remains a major unmet clinical need, and current therapies targeting neurohomonal and hemodynamic regulation have limited efficacy. The pathological remodeling of the myocardium has been associated with a stereotypical gene expression program, which had long been viewed as the consequence and not the driver of the disease until very recently. Despite the advance, there is no therapy available to reverse the already committed gene program. Here, we demonstrate that transcriptional repressor REV-ERB binds near driver transcription factors across the genome...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28877526/-einstellung-von-%C3%A3-rzten-gegen%C3%A3-ber-komplement%C3%A3-rmedizin-in-einer-l%C3%A3-ndlichen-region-der-schweiz-ergebnisse-einer-umfrage
#10
Gudrun Marszalek, Loredana Torchetti, Jürgen Barth, Ursula Wolf, Martin Frei-Erb
No abstract text is available yet for this article.
September 7, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28875504/zenker-s-diverticulum-submucosal-tunneling-endoscopic-septum-division-z-poem
#11
Oscar Víctor Hernandez Mondragón, Omar Michel Solórzano Pineda, Juan Manuel Blancas Valencia
BACKGROUND: Zenker diverticulum is characterized by dysphagia, weight loss and bronchoaspiration [1]. Open surgery has been the cornerstone of treatment, with good response but recurrence up to 35%.[2]. Rigid endoscopic diverticulotomy has similar results, but with conversion to open surgery up to 30%[3]. Flexible endoscopic diverticulotomy is safe, effective and can be performed in an endoscopic setting, but multiple sessions are needed because of uncomplete cut of the septum[4,5]. Z-POEM is a new procedure in which a total septum myotomy throughout a submucosal tunnel can be performed...
September 6, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28872044/insular-cognitive-impairment-at-the-early-stage-of-dementia-with-lewy-bodies-a-preliminary-study
#12
Nathalie Philippi, Jennifer Kemp, Morgane Constans-Erbs, Malik Hamdaoui, Laetitia Monjoin, Emmanuelle Ehrhard, Timothée Albasser, Anne Botzung, Catherine Demuynck, Géraldine Heim, Catherine Martin-Hunyadi, Mathias Bilger, Laetitia Berly, David Soulier, Benjamin Cretin, Olivier Després, Frédéric Blanc
BACKGROUND: The anterior part of the insula appears atrophied in the early stage of dementia with Lewy bodies (DLB) whereas it is not the case in early Alzheimer's disease (AD). OBJECTIVE: The objective of this study was to develop neuropsychological markers supposed to reflect insular dysfunction, which would facilitate early diagnosis of DLB, namely in comparison to AD. METHODS: Twelve patients with DLB, 12 patients with AD, all at the stage of Mild cognitive impairment (MCI) or mild dementia, as well as 10 Controls subjects (CS) participated in the study...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28871450/cup-detachment-during-vacuum-assisted-vaginal-delivery-and-birth-outcome
#13
Eyal Krispin, Amir Aviram, Lina Salman, Rony Chen, Arnon Wiznitzer, Rinat Gabbay-Benziv
OBJECTIVE: To determine the perinatal outcome associated with cup detachment during vacuum-assisted vaginal delivery (VAVD). METHODS: A retrospective cohort study of all women attempting VAVD in a tertiary hospital (2012-2014). Singleton-term pregnancies were included. Antepartum fetal death and major fetal structural or chromosomal abnormalities were excluded. Primary outcome was neonatal birth trauma (subgaleal hematoma, subarachnoid hematoma, subdural hematoma, skull fracture, and/or erb's palsy)...
September 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28855295/corticospinal-excitability-of-the-biceps-brachii-is-shoulder-position-dependent
#14
Brandon Wayne Collins, E W J Cadigan, Lucas Stefanelli, Duane C Button
The purpose of this study was to examine the effect of shoulder position on corticospinal excitability (CSE) of the biceps brachii during rest and a 10% maximal voluntary contraction (MVC). Participants (n=9) completed two experimental sessions with four conditions: 1) rest, 0° shoulder flexion, 2) 10% MVC, 0° shoulder flexion 3) rest, 90° shoulder flexion 4) 10% MVC, 90° shoulder flexion. Transcranial magnetic, transmastoid electrical and Erb's point stimulation were used to induce motor-evoked potentials (MEPs), cervicomedullary MEPs (CMEPs) and maximal muscle compound potentials (Mmax), respectively, in the biceps brachii in each condition...
August 30, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28854595/dormancy-and-activation-of-human-oocytes-from-primordial-and-primary-follicles-molecular-clues-to-oocyte-regulation
#15
E H Ernst, M L Grøndahl, S Grund, K Hardy, A Heuck, L Sunde, S Franks, C Y Andersen, P Villesen, K Lykke-Hartmann
STUDY QUESTION: Do specific transcriptome dynamics in human oocytes from primordial and primary follicles identify novel pathways in oocyte activation? SUMMARY ANSWER: The transcriptomic profiles in oocytes from primordial and primary follicles, respectively, revealed several new canonical pathways as putative mediators of oocyte dormancy and activation. WHAT IS KNOWN ALREADY: Cellular signaling pathways including PI3K/AKT and AKT/mTOR as well as TGF-β and IGF signaling are known to regulate the primordial-to-primary transition in mammalian follicle development...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28851928/calorie-restriction-effects-on-circadian-rhythms-in-gene-expression-are-sex-dependent
#16
Artem A Astafev, Sonal A Patel, Roman V Kondratov
The rhythms in the expression of circadian clock genes are affected by calorie restriction (CR), a dietary paradigm known to increase lifespan. Many physiological effects of CR differ between males and females; here we investigated if the sex of animals affects the CR induced changes in the circadian rhythms. The liver expression of some circadian clock genes such as Bmal1 and three Periods (Per1, Per2 and Per3) and the effect of CR on the expression of these genes were sex independent, while the expression of Rev-Erb alpha, Ror gamma and both Cryptochome (Cry1 and Cry2) genes was different between males and females...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843902/relationship-between-chronobiological-thyrotropin-and-prolactin-responses-to-protirelin-trh-and-suicidal-behavior-in-depressed-patients
#17
Fabrice Duval, Marie-Claude Mokrani, Alexis Erb, Felix Gonzalez Opera, Cécile Calleja, Véronique Paris
BACKGROUND: So far, investigations of the relationships between suicidality and the activity of the thyrotropic and lactotropic axes are scarce and have yielded conflicting results. METHODS: We studied the thyrotropin (TSH) and prolactin (PRL) responses to 0800h and 2300h protirelin (TRH) stimulation tests, carried out on the same day, in 122 euthyroid DSM-5 major depressed inpatients with suicidal behavior disorder (SBD) (either current [n=71], or in early remission [n=51]); and 50 healthy hospitalized controls...
July 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28843191/a-short-history-of-rubisco-the-rise-and-fall-of-nature-s-predominant-co2-fixing-enzyme
#18
REVIEW
Tobias J Erb, Jan Zarzycki
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO) is arguably one of the most abundant proteins in the biosphere and a key enzyme in the global carbon cycle. Although RubisCO has been intensively studied, its evolutionary origins and rise as Nature's most dominant carbon dioxide (CO2)-fixing enzyme still remain in the dark. In this review we will bring together biochemical, structural, physiological, microbiological, as well as phylogenetic data to speculate on the evolutionary roots of the CO2-fixation reaction of RubisCO, the emergence of RubisCO-based autotrophic CO2-fixation in the context of the Calvin-Benson-Bassham cycle, and the further evolution of RubisCO into the 'RubisCOsome', a complex of various proteins assembling and interacting with the enzyme to improve its operational capacity (functionality) under different biological and environmental conditions...
August 29, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28835374/low-affinity-binding-in-cis-to-p2y2r-mediates-force-dependent-integrin-activation-during-hantavirus-infection
#19
Virginie Bondu, Chenyu Wu, Wenpeng Cao, Peter C Simons, Jennifer Gillette, Jieqing Zhu, Laurie Erb, X Frank Zhang, Tione Buranda
Pathogenic hantaviruses bind to the Plexin Semaphorin Integrin (PSI) domain of inactive, β3 integrins. Previous studies have implicated a cognate cis interaction between the bent conformation β5/β3 integrins and an RGD sequence in the first extracellular loop of P2Y2R (Erb et al., 2001). With single-molecule atomic force microscopy, we show a cognate interaction between (RGD)P2Y2R and an AFM tip decorated with recombinant αIIbβ3 integrins expressed on cell membranes. Mutation of the RGD sequence to RGE in the P2Y2R removes this interaction...
August 23, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28830467/biclamp%C3%A2-vessel-sealing-device-for-open-hepatic-resection-of-malignant-and-benign-liver-tumours-a-single-institution-experience
#20
Yi-Jun Zhao, Da-Chen Zhou, Fu-Bao Liu, Hong-Chuan Zhao, Guo-Bin Wang, Xiao-Ping Geng
BACKGROUND: Intraoperative blood loss during hepatectomy worsens prognosis, and various tools have been used to improve perioperative safety and feasibility. We aimed to retrospectively evaluate the feasibility and safety of the BiClamp® device for open liver resection. METHODS: We included 84 patients undergoing liver resection from a single centre, with all patients operated by the same surgical group. All hepatectomies were performed using BiClamp® (Erbe Elektromedizin GmbH, Tubingen, Germany), an electrosurgical device that simultaneously transects liver parenchyma and seals vessels <7 mm in diameter...
August 22, 2017: BMC Cancer
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