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https://www.readbyqxmd.com/read/28088409/genome-wide-association-analysis-and-pathways-enrichment-for-lactation-persistency-in-canadian-holstein-cattle
#1
D N Do, N Bissonnette, P Lacasse, F Miglior, M Sargolzaei, X Zhao, E M Ibeagha-Awemu
Lactation persistency (LP), defined as the rate of declining milk yield after milk peak, is an economically important trait for dairy cattle. Improving LP is considered a good alternative method for increasing overall milk production because it does not cause the negative energy balance and other health issues that cows experience during peak milk production. However, little is known about the biology of LP. A genome-wide association study (GWAS) and pathway enrichment were used to explore the genetic mechanisms underlying LP...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28077399/her2-testing-and-clinical-decision-making-in-gastroesophageal-adenocarcinoma-guideline-from-the-college-of-american-pathologists-american-society-for-clinical-pathology-and-american-society-of-clinical-oncology
#2
REVIEW
Angela N Bartley, Mary Kay Washington, Christina B Ventura, Nofisat Ismaila, Carol Colasacco, Al B Benson, Alfredo Carrato, Margaret L Gulley, Dhanpat Jain, Sanjay Kakar, Helen J Mackay, Catherine Streutker, Laura Tang, Megan Troxell, Jaffer A Ajani
CONTEXT: ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA. OBJECTIVES: To establish an evidence-based guideline for HER2 testing in patients with GEA, to formalize the algorithms for methods to improve the accuracy of HER2 testing while addressing which patients and tumor specimens are appropriate, and to provide guidance on clinical decision making...
December 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28076919/use-of-treatment-and-counseling-services-and-mind-body-techniques-by-students-with-emotional-and-behavioral-difficulties
#3
Wasantha Jayawardene, Ryan Erbe, David Lohrmann, Mohammad Torabi
BACKGROUND: School-based treatment and counseling services (TCSs) can integrate mind-body techniques (MBTs) to improve children's health, wellness, and academic performance. We aimed to describe the effect of school-based TCS on MBT-use among students experiencing difficulties with concentration, emotions, behaviors, and getting along (DCEBG). METHODS: National Health Interview Survey data were utilized (N2007  = 1225; N2012  = 1835). Logistic regression examined associations between TCS-type and MBT-use, while propensity score matching controlled for confounders in the prematch sample...
February 2017: Journal of School Health
https://www.readbyqxmd.com/read/28074037/developmental-pruning-of-excitatory-synaptic-inputs-to-parvalbumin-interneurons-in-monkey-prefrontal-cortex
#4
Daniel W Chung, Zachary P Wills, Kenneth N Fish, David A Lewis
Working memory requires efficient excitatory drive to parvalbumin-positive (PV) interneurons in the primate dorsolateral prefrontal cortex (DLPFC). Developmental pruning eliminates superfluous excitatory inputs, suggesting that working memory maturation during adolescence requires pruning of excitatory inputs to PV interneurons. Therefore, we tested the hypothesis that excitatory synapses on PV interneurons are pruned during adolescence. The density of excitatory synapses, defined by overlapping vesicular glutamate transporter 1-positive (VGlut1+) and postsynaptic density 95-positive (PSD95+) puncta, on PV interneurons was lower in postpubertal relative to prepubertal monkeys...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28072861/identification-of-the-molecular-clockwork-of-the-oyster-crassostrea-gigas
#5
Mickael Perrigault, Damien Tran
Molecular clock system constitutes the origin of biological rhythms that allow organisms to anticipate cyclic environmental changes and adapt their behavior and physiology. Components of the molecular clock are largely conserved across a broad range of species but appreciable diversity in clock structure and function is also present especially in invertebrates. The present work aimed at identify and characterize molecular clockwork components in relationship with the monitoring of valve activity behavior in the oyster Crassostrea gigas...
2017: PloS One
https://www.readbyqxmd.com/read/28071183/5-aminosalicylic-acid-inhibits-inflammatory-responses-by-suppressing-jnk-and-p38-activity-in-murine-macrophages
#6
Tingli Qu, Erbing Wang, Baofen Jin, Weiping Li, Ruiling Liu, Zheng-Bao Zhao
CONTEXT: 5-Aminosalicylic acid (5-ASA), as an anti-inflammatory drug, has been extensively used for the treatment of mild to moderate active ulcerative colitis (UC), but the possible mechanisms of action remain unclear. OBJECTIVE: To investigate the effects of 5-ASA on the production of inflammatory mediators by murine macrophages stimulated with lipopolysaccharide (LPS), and determine the underlying pharmacological mechanism of action. MATERIALS AND METHODS: The levels of nitric oxide (NO) and interleukin-6 (IL-6) were measured by Varioskan Flash and IL-6 Enzyme-Linked Immunosorbent Assay sets...
February 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28064353/who-is-a-healthy-subject-consensus-results-on-pivotal-eligibility-criteria-for-clinical-trials
#7
REVIEW
Kerstin Breithaupt-Groegler, Christoph Coch, Martin Coenen, Frank Donath, Katharina Erb-Zohar, Klaus Francke, Karin Goehler, Mario Iovino, Klaus Peter Kammerer, Gerd Mikus, Jens Rengelshausen, Hildegard Sourgens, Reinhard Schinzel, Thomas Sudhop, Georg Wensing
INTRODUCTION/METHODS: A discussion forum was hosted by the German not-for-profit Association for Applied Human Pharmacology (AGAH e.V.) to critically review key eligibility criteria and stopping rules for clinical trials with healthy subjects, enrolling stakeholders from the pharmaceutical industry, contract research organisations, academia, ethics committees and competent authority. RESULTS: Pivotal eligibility criteria were defined for trials with new investigational medicinal products (IMPs) or with clinically established IMPs...
January 7, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28050336/effects-of-preventive-online-mindfulness-interventions-on-stress-and-mindfulness-a-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Wasantha P Jayewardene, David K Lohrmann, Ryan G Erbe, Mohammad R Torabi
Empirical evidence suggested that mind-body interventions can be effectively delivered online. This study aimed to examine whether preventive online mindfulness interventions (POMI) for non-clinical populations improve short- and long-term outcomes for perceived-stress (primary) and mindfulness (secondary). Systematic search of four electronic databases, manuscript reference lists, and journal content lists was conducted in 2016, using 21 search-terms. Eight randomized controlled trials (RCTs) evaluating effects of POMI in non-clinical populations with adequately reported perceived-stress and mindfulness measures pre- and post-intervention were included...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28049412/genomic-prediction-with-epistasis-models-on-the-marker-coding-dependent-performance-of-the-extended-gblup-and-properties-of-the-categorical-epistasis-model-ce
#9
Johannes W R Martini, Ning Gao, Diercles F Cardoso, Valentin Wimmer, Malena Erbe, Rodolfo J C Cantet, Henner Simianer
BACKGROUND: Epistasis marker effect models incorporating products of marker values as predictor variables in a linear regression approach (extended GBLUP, EGBLUP) have been assessed as potentially beneficial for genomic prediction, but their performance depends on marker coding. Although this fact has been recognized in literature, the nature of the problem has not been thoroughly investigated so far. RESULTS: We illustrate how the choice of marker coding implicitly specifies the model of how effects of certain allele combinations at different loci contribute to the phenotype, and investigate coding-dependent properties of EGBLUP...
January 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28046755/su-f-j-122-rectal-sparing-reproducibility-in-prostate-cancer-patients-treated-with-hydrogel-spacer-and-proton-therapy
#10
S Hedrick, S Case, B Robison, M Blakey, M Artz, J Renegar, A Schreuder, M Fagundes
PURPOSE: Rectal hydrogel spacer has been shown to improve rectal sparing in prostate radiotherapy. The purpose of this study was to determine the reproducibility of rectal sparing throughout treatment in patients undergoing proton therapy. METHODS: At our facility, prostate cancer patients are treated with pencil beam scanning proton therapy, utilizing an endorectal balloon (ERB) or rectal spacer hydrogel (Gel) "SpaceOAR" implant. All patients were treated with a full bladder and empty rectum (low residue diet and stool softeners)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28028219/future-urban-land-expansion-and-implications-for-global-croplands
#11
Christopher Bren d'Amour, Femke Reitsma, Giovanni Baiocchi, Stephan Barthel, Burak Güneralp, Karl-Heinz Erb, Helmut Haberl, Felix Creutzig, Karen C Seto
Urban expansion often occurs on croplands. However, there is little scientific understanding of how global patterns of future urban expansion will affect the world's cultivated areas. Here, we combine spatially explicit projections of urban expansion with datasets on global croplands and crop yields. Our results show that urban expansion will result in a 1.8-2.4% loss of global croplands by 2030, with substantial regional disparities. About 80% of global cropland loss from urban expansion will take place in Asia and Africa...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28018304/identification-of-electrode-respiring-hydrocarbonoclastic-bacterial-strain-stenotrophomonas-maltophilia-mk2-highlights-the-untapped-potential-for-environmental-bioremediation
#12
Krishnaveni Venkidusamy, Mallavarapu Megharaj
Electrode respiring bacteria (ERB) possess a great potential for many biotechnological applications such as microbial electrochemical remediation systems (MERS) because of their exoelectrogenic capabilities to degrade xenobiotic pollutants. Very few ERB have been isolated from MERS, those exhibited a bioremediation potential toward organic contaminants. Here we report once such bacterial strain, Stenotrophomonas maltophilia MK2, a facultative anaerobic bacterium isolated from a hydrocarbon fed MERS, showed a potent hydrocarbonoclastic behavior under aerobic and anaerobic environments...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28003019/agonists-and-knockdown-of-estrogen-receptor-%C3%AE-differentially-affect-invasion-of-triple-negative-breast-cancer-cells-in-vitro
#13
Susanne Schüler-Toprak, Julia Häring, Elisabeth C Inwald, Christoph Moehle, Olaf Ortmann, Oliver Treeck
BACKGROUND: Estrogen receptor β (ERβ) is expressed in the majority of invasive breast cancer cases, irrespective of their subtype, including triple-negative breast cancer (TNBC). Thus, ERβ might be a potential target for therapy of this challenging cancer type. In this in vitro study, we examined the role of ERβ in invasion of two triple-negative breast cancer cell lines. METHODS: MDA-MB-231 and HS578T breast cancer cells were treated with the specific ERβ agonists ERB-041, WAY200070, Liquiritigenin and 3β-Adiol...
December 21, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27995168/data-on-the-effect-of-pro-fibrotic-cytokine-tgf-%C3%AE-on-hepatic-stellate-cell-autophagy
#14
Paul G Thomes, Elizabeth Brandon-Warner, Ting Li, Terrence M Donohue, Laura W Schrum
Our data describe autophagic flux in primary rat hepatic stellate cells (rHSCs) treated with pro-fibrotic growth factor, transforming growth factor beta (TGF-β). An autophagy flux experiment determines the rate of synthesis and degradation of the autophagosome marker, LC3-II in the presence and absence of the lysosomal inhibitor bafilomcyin, which blocks LC3-II degradation in lysosomes. The effects of a test agent on LC3-II flux through the autophagic pathway is determined immunochemically by its relative amounts detected in lysates of cells treated with and without bafilomycin...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27992240/quality-matters-2016-annual-conference-of-the-national-infrastructures-for-biobanking
#15
Marika Doucet, Karl Friedrich Becker, Jens Björkman, Jacques Bonnet, Bruno Clément, Maria-Grazia Daidone, Charles Duyckaerts, Gilles Erb, Helmuth Haslacher, Paul Hofman, Berthold Huppertz, Christophe Junot, Joakim Lundeberg, Andres Metspalu, Marialuisa Lavitrano, Jan-Eric Litton, Helen Moore, Manuel Morente, Ben-Youssef Naimi, Uwe Oelmueller, Bill Ollier, Barbara Parodi, Liangliang Ruan, Giorgio Stanta, Paola Turano, Jim Vaught, Peter Watson, H-Erich Wichmann, Martin Yuille, Myriam Zaomi, Kurt Zatloukal, Georges Dagher
No abstract text is available yet for this article.
December 19, 2016: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/27988807/effects-of-bright-light-exposure-during-daytime-on-peripheral-clock-gene-expression-in-humans
#16
Maki Sato, Tomoko Wakamura, Takeshi Morita, Akihiko Okamoto, Makoto Akashi, Takuya Matsui, Motohiko Sato
Light is the strongest synchronizer controlling circadian rhythms. The intensity and duration of light change throughout the year, thereby influencing body weight, food preferences, and melatonin secretion in humans and animals. Although the expression of clock genes has been examined using human samples, it currently remains unknown whether bright light during the daytime affects the expression of these genes in humans. Therefore, we herein investigated the effects of bright light exposure during the daytime on clock gene expression in the hair follicular and root cells of the human scalp...
December 17, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27986498/comparison-of-auditory-stream-segregation-in-sighted-and-early-blind-individuals
#17
Fatemeh Moghadasi Boroujeni, Fatemeh Heidari, Masoumeh Rouzbahani, Mohammad Kamali
An important characteristic of the auditory system is the capacity to analyze complex sounds and make decisions on the source of the constituent parts of these sounds. Blind individuals compensate for the lack of visual information by an increase input from other sensory modalities, including increased auditory information. The purpose of the current study was to compare the fission boundary (FB) threshold of sighted and early blind individuals through spectral aspects using a psychoacoustic auditory stream segregation (ASS) test...
December 13, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27976453/seasonality-constraints-to-livestock-grazing-intensity
#18
Tamara Fetzel, Petr Havlik, Mario Herrero, Karl-Heinz Erb
Increasing food production is essential to meet the future food demand of a growing world population. In the light of pressing sustainability challenges like climate change and the importance of the global livestock system for food security as well as GHG emissions, finding ways to increasing food production sustainably and without increasing competition for food crops is essential. Yet, many unknowns relate to livestock grazing, in particular grazing intensity, an essential variable to assess the sustainability of livestock systems...
December 14, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27975563/chemical-evaluation-and-microbiological-assays-of-medicinal-plants-used-in-traditional-communities-in-northeastern-brazil
#19
J P Ferreira-Neto, Rjsa Padilha, Erb Santana, D N Gomes, Kxfr Sena, Lpm Magalhães, R Yara, Csa Lima
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27964752/extreme-genomic-erosion-after-recurrent-demographic-bottlenecks-in-the-highly-endangered-iberian-lynx
#20
Federico Abascal, André Corvelo, Fernando Cruz, José L Villanueva-Cañas, Anna Vlasova, Marina Marcet-Houben, Begoña Martínez-Cruz, Jade Yu Cheng, Pablo Prieto, Víctor Quesada, Javier Quilez, Gang Li, Francisca García, Miriam Rubio-Camarillo, Leonor Frias, Paolo Ribeca, Salvador Capella-Gutiérrez, José M Rodríguez, Francisco Câmara, Ernesto Lowy, Luca Cozzuto, Ionas Erb, Michael L Tress, Jose L Rodriguez-Ales, Jorge Ruiz-Orera, Ferran Reverter, Mireia Casas-Marce, Laura Soriano, Javier R Arango, Sophia Derdak, Beatriz Galán, Julie Blanc, Marta Gut, Belen Lorente-Galdos, Marta Andrés-Nieto, Carlos López-Otín, Alfonso Valencia, Ivo Gut, José L García, Roderic Guigó, William J Murphy, Aurora Ruiz-Herrera, Tomas Marques-Bonet, Guglielmo Roma, Cedric Notredame, Thomas Mailund, M Mar Albà, Toni Gabaldón, Tyler Alioto, José A Godoy
BACKGROUND: Genomic studies of endangered species provide insights into their evolution and demographic history, reveal patterns of genomic erosion that might limit their viability, and offer tools for their effective conservation. The Iberian lynx (Lynx pardinus) is the most endangered felid and a unique example of a species on the brink of extinction. RESULTS: We generate the first annotated draft of the Iberian lynx genome and carry out genome-based analyses of lynx demography, evolution, and population genetics...
December 14, 2016: Genome Biology
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