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Barbara J Wilson, Laura J Zitella, Colleen H Erb, Jackie Foster, Mary Peterson, Sylvia K Wood
BACKGROUND: Cancer-related infections lead to increases in mortality, antibiotic use, and hospital stays. Other adverse outcomes include dose delays and reductions, which can result in suboptimal treatment outcomes. OBJECTIVES: Effective implementation of risk assessment and evidence-based interventions for the prevention and treatment of infection are essential to improve care and reduce costs related to infections in patients with cancer receiving immunosuppressive therapy...
April 1, 2018: Clinical Journal of Oncology Nursing
Tim Beissinger, Jochen Kruppa, David Cavero, Ngoc-Thuy Ha, Malena Erbe, Henner Simianer
Important traits in agricultural, natural, and human populations are increasingly being shown to be under the control of many genes that individually contribute only a small proportion of genetic variation. However, the majority of modern tools in quantitative and population genetics, including genome wide association studies and selection mapping protocols, are designed to identify individual genes with large effects. We have developed an approach to identify traits that have been under selection and are controlled by large numbers of loci...
March 15, 2018: Genetics
Christina Balderrama-Durbin, Christopher R Erbes, Melissa A Polusny, Dawne Vogt
Intimate partner communication has become a part of the daily routine of military couples during deployment. However, there is a scarcity of research examining the individual and relationship implications of communication during deployment, likely due in part to the lack of existing measures of deployment communication. The current study examined the psychometric characteristics of a newly developed, multidimensional tool for assessing the process and outcomes of deployment communication in a sample of 391 recently deployed male Army National Guard soldiers and their female intimate partners...
February 2018: Journal of Family Psychology: JFP
Lu Wang, Bo Jiang, Per Erik Vullum, Ann Mari Svensson, Andreas Erbe, Sverre M Selbach, Huailiang Xu, Fride Vullum-Bruer
A rechargeable Mg battery where the capacity mainly originates from reversible reactions occurring at the electrode/electrolyte interface efficiently avoids the challenge of sluggish Mg intercalation encountered in conventional Mg batteries. The interfacial reactions in a cell based on microwave exfoliated graphite oxide (MEGO) as the cathode, and all phenyl complex (APC) as electrolyte, are by quantitative kinetics analysis identified as a combination of diffusion-controlled reactions involving ether solvents (esols) and capacitive processes...
March 14, 2018: ACS Nano
Ning Wei, Michelle L Gumz, Anita T Layton
Major renal functions such as renal blood flow, glomerular filtration rate, and urinary excretion are known to exhibit circadian oscillations. However, the underlying mechanisms that govern these variations have yet to be fully elucidated. To better understand the impact of the circadian clock on renal solute and water transport, we have developed a computational model of the renal circadian clock, and coupled that model to an epithelial transport model of the proximal convoluted cell of the rat kidney. The activity of the Na$^+$-H$^+$ exchanger 3 (NHE3) is assumed to be regulated by changes in transcription of the NHE3 mRNA due to regulation by circadian clock proteins...
March 14, 2018: American Journal of Physiology. Renal Physiology
Shixiong Min, Jianhua Hou, Yonggang Lei, Xiangyu Liu, Yanan Li, Yuan Xue, Entian Cui, Wenjun Yan, Wanxiu Hai, Fang Wang
CoAl-layered double hydroxide nanosheets (CoAl-NSs) could serve as an active matrix to effectively anchor amorphous MoSx nanoparticles with high dispersion and the formation of an additional active "CoMoS" phase. The resulting CoAl-NSs/MoSx catalyst showed 13 times higher H2 evolution activity than free MoSx nanoparticles from an erythrosin B-triethanolamine (ErB-TEOA) system under visible light.
March 14, 2018: Chemical Communications: Chem Comm
Marlysa B Sullivan, Matt Erb, Laura Schmalzl, Steffany Moonaz, Jessica Noggle Taylor, Stephen W Porges
Yoga therapy is a newly emerging, self-regulating complementary and integrative healthcare (CIH) practice. It is growing in its professionalization, recognition and utilization with a demonstrated commitment to setting practice standards, educational and accreditation standards, and promoting research to support its efficacy for various populations and conditions. However, heterogeneity of practice, poor reporting standards, and lack of a broadly accepted understanding of the neurophysiological mechanisms involved in yoga therapy limits the structuring of testable hypotheses and clinical applications...
2018: Frontiers in Human Neuroscience
Aya Sasaki, Patrick O McGowan, Suzanne Erb
Building on previous work in the field, we examined the effect of maternal high fat diet (HFD) during gestation and lactation on the sensitivity of male and female adult offspring to acute and repeated cocaine exposures, and to the expression of cocaine-induced anxiety in the elevated plus maze (EPM). In both male and female offspring, acute injections of cocaine induced a strong locomotor-activating effect; repeated injections produced a robust conditioned locomotor response to the context in which they were given cocaine, and heightened activity in response to a subsequent acute challenge of cocaine...
March 10, 2018: Neuroscience Letters
Marie Pariollaud, Julie Gibbs, Thomas Hopwood, Sheila Brown, Nicola Begley, Ryan Vonslow, Toryn Poolman, Baoqiang Guo, Ben Saer, D Heulyn Jones, James P Tellam, Stefano Bresciani, Nicholas Co Tomkinson, Justyna Wojno-Picon, Anthony Wj Cooper, Dion A Daniels, Ryan P Trump, Daniel Grant, William Zuercher, Timothy M Willson, Andrew S MacDonald, Brian Bolognese, Patricia L Podolin, Yolanda Sanchez, Andrew Si Loudon, David W Ray
Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERB as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid, and bronchial epithelial cells in temporal gating and determining amplitude of response to inhaled endotoxin. Dual mutation of REV-ERBα and its paralog REV-ERBβ in bronchial epithelia further augmented inflammatory responses and chemokine activation, but also initiated a basal inflammatory state, revealing a critical homeostatic role for REV-ERB proteins in the suppression of the endogenous pro-inflammatory mechanism in un-challenged cells...
March 13, 2018: Journal of Clinical Investigation
Robert P Dickson, John R Erb-Downward, Nicole R Falkowski, Ellen M Hunter, Shanna L Ashley, Gary B Huffnagle
RATIONALE: The "gut-lung axis" is commonly invoked to explain the microbiome's influence on lung inflammation. Yet the lungs harbor their own microbiome which is altered in respiratory disease. The relative influence of gut and lung bacteria on lung inflammation is unknown. OBJECTIVES: To determine if baseline lung immune tone reflects local (lung-lung) or remote (gut-lung) microbe-host interactions. METHODS: We compared lung, tongue, and cecal bacteria in forty healthy, genetically-identical 10-week old mice using 16S rRNA gene quantification and sequencing...
March 13, 2018: American Journal of Respiratory and Critical Care Medicine
Bastian Vögeli, Sylvain Engilberge, Eric Girard, François Riobé, Olivier Maury, Tobias J Erb, Seigo Shima, Tristan Wagner
Many reactions within a cell are thermodynamically unfavorable. To efficiently run some of those endergonic reactions, nature evolved intermediate-channeling enzyme complexes, in which the products of the first endergonic reactions are immediately consumed by the second exergonic reactions. Based on this concept, we studied how archaea overcome the unfavorable first reaction of isoprenoid biosynthesis-the condensation of two molecules of acetyl-CoA to acetoacetyl-CoA catalyzed by acetoacetyl-CoA thiolases (thiolases)...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
Florina Erbeli, Sara A Hart, Richard K Wagner, Jeanette Taylor
A fairly recent definition of reading disability (RD) is that in the form of a hybrid model. The model views RD as a latent construct that is manifested through various observable unexpected impairments in reading related skills and through inadequate response to intervention. The current report evaluated this new conceptualization of RD from an etiological perspective. The sample consisted of 2737 twin pairs in first through fourth grade ( M age = 8.52) from the Florida Twin Project on Reading. Using twin analyses, results showed that a substantial proportion of genetic variance, a small proportion of shared environmental, and a small proportion of non-shared environmental variance was attributed to the RD factor...
2018: Scientific Studies of Reading
Ji-Liang Zhang, Min Liu, Chun-Nuan Zhang, Er-Chao Li, Ming-Zhen Fan, Mao-Xian Huang
The brain of fish displays sexual dimorphisms and exhibits remarkable sexual plasticity throughout their life span. Although reproductive toxicity of tributyltin (TBT) in fish is well documented in fish, it remains unknown whether TBT interrupts sexual dimorphisms of fish brains. In this work, brain transcriptomic profiles of rare minnow (Gobiocypris rarus) was characterized and sex-biased genes were identified using RNA sequencing. Functional annotation and enrichment analysis were performed to reveal differences of gene products and pathways between the brains of male and female fish...
March 7, 2018: Ecotoxicology and Environmental Safety
Grant Matthews
A need to gain more confidence in computer model predictions of coming climate change has resulted in greater analysis of the quality of orbital Earth radiation budget (ERB) measurements being used today to constrain, validate, and hence improve such simulations. These studies conclude from time series analysis that for around a quarter of a century, no existing satellite ERB climate data record is of a sufficient standard to partition changes to the Earth from those of un-tracked and changing artificial instrumentation effects...
March 1, 2018: Applied Optics
Neeraj Agarwal, Sumanta K Pal, Andrew W Hahn, Roberto H Nussenzveig, Gregory R Pond, Sumati V Gupta, Jue Wang, Mehmet A Bilen, Gurudatta Naik, Pooja Ghatalia, Christopher J Hoimes, Dharmesh Gopalakrishnan, Pedro C Barata, Alexandra Drakaki, Bishoy M Faltas, Lesli A Kiedrowski, Richard B Lanman, Rebecca J Nagy, Nicholas J Vogelzang, Kenneth M Boucher, Ulka N Vaishampayan, Guru Sonpavde, Petros Grivas
BACKGROUND: Biomarker-guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not available are not eligible. Technological advancements in sequencing have made cell-free circulating DNA (cfDNA) next-generation sequencing (NGS) readily available in the clinic. The objective of the current study was to determine whether the genomic profile of mUC detected by NGS of cfDNA is similar to historical tumor tissue NGS studies...
March 8, 2018: Cancer
Nicole Zimmermann, Svea Brandt, Jeanette Brünner, Carl Erb
INTRODUCTION: Our study compares the biomechanical properties of the cornea in patients with long-term pre-existing (for at least 10 years) systemic sclerosis (SSc) with those of healthy suspects. MATERIAL/METHODS: The examination was performed in 14 systemic SSc patients and 38 healthy volunteers. Non-invasive assessment of corneal biomechanical parameters, including central corneal thickness (CCT), corneal hysteresis (CH) and corneal resistance factor (CRF), was performed in one randomised study eye in accordance with a standardised protocol...
March 7, 2018: Klinische Monatsblätter Für Augenheilkunde
Yuki Ohba, Hajime Tei
Circadian rhythms are generated by the cyclic expression of several clock genes in mammals. The rhythmic expression of these genes is maintained by multiple transcriptional-translational feedback loops in addition to the posttranslational regulation of the clock proteins. Transcription of one of the key clock genes, Bmal1, which exhibits a nocturnal transcriptional rhythm in the suprachiasmatic nucleus of the mouse brain, is induced and repressed by RORs and REV-ERBs, respectively. Thus, the dynamics of the RORs and REV-ERBs expression, modification, subcellular localization and degradation of these transcriptional factors are critical for the transcriptional regulation of Bmal1...
March 6, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Lara N Gechijian, Dennis L Buckley, Matthew A Lawlor, Jaime M Reyes, Joshiawa Paulk, Christopher J Ott, Georg E Winter, Michael A Erb, Thomas G Scott, Mousheng Xu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Nicholas P Kwiatkowski, Jennifer A Perry, Jun Qi, Nathanael S Gray, James E Bradner
The addressable pocket of a protein is often not functionally relevant in disease. This is true for the multidomain, bromodomain-containing transcriptional regulator TRIM24. TRIM24 has been posited as a dependency in numerous cancers, yet potent and selective ligands for the TRIM24 bromodomain do not exert effective anti-proliferative responses. We therefore repositioned these probes as targeting features for heterobifunctional protein degraders. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24...
March 5, 2018: Nature Chemical Biology
Nicolas Krink-Koutsoubelis, Anne Christina Loechner, Anna Lechner, Hannes Link, Charles M Denby, Bastian Voegeli, Tobias J Erb, Satoshi Yuzawa, Tadas Jakociunas, Leonard Katz, Michael K Jensen, Victor Sourjik, Jay D Keasling
Short chain acyl-coenzyme A esters serve as intermediate compounds in fatty acid biosynthesis, and the production of polyketides, biopolymers and other value-added chemicals. S. cerevisiae is a model organism that has been utilized for the biosynthesis of such biologically and economically valuable compounds. However, its limited repertoire of short chain acyl-CoAs effectively prevents its application as a production host for a plethora of natural products. Therefore, we introduced biosynthetic metabolic pathways to five different acyl-CoA esters into S...
March 2, 2018: ACS Synthetic Biology
Erbing Hua, Gang Liu, Guan Zhang, Xiaoxiang Xu
Separation of photo-generated electron-hole pairs plays a crucial role in determining the practical performance of semiconductor photocatalysts. Here we have successfully fabricated two dimensional g-C3 N4 /Ba5 Ta4 O15 nanosheet heterostructures through an in situ urea degradation method. The so-formed nanosheet heterostructures demonstrate superior photocatalytic activities in H2 evolution reactions over individual component. Further analysis using photoelectrochemical measurements suggests efficient charge separations at the interfaces of these heterostructures which contribute to a prolonged lifetime of photo-generated charges as well as the much enhanced photocatalytic activities...
March 1, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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